2 results about "Fast onset" patented technology

Provided are a new type of benzodiazepine compound, a preparation method thereof, and a use thereof. The short-acting benzodiazepine derivative has the characteristics of rapid onset, short action time, strong depth, fast metabolism, and fast awakening. In the anesthesia experiments on mice and rats, the short-acting benzodiazepine derivative has an onset time comparable to that of remazepam, but the action time and awakening time are significantly shortened, and the action depth of some compounds is significantly enhanced, and has the characteristics of faster onset, shorter action time, greater action strength, faster metabolism, and faster awakening. In the long-term infusion anesthesia experiment on rats, compared with remazepam, the short-acting benzodiazepine derivative has significantly shortened awakening time and recovery time, and has the characteristics of faster awakening and faster recovery.

The present invention provides a substituted tetrahydrofuran-formamide derivative, a salt or stereoisomer, a pharmaceutical composition containing same, a use thereof as a Nav inhibitor, and a use thereof in preparation of a drug for treating and / or alleviating pain and pain-related diseases. The compound provided in the present invention has the advantages of high metabolic stability, high oral absorption, better bioavailability, better activity, higher selectivity, better pharmacokinetic properties, faster onset of action, and low central nervous system side effects.