4 results about "Fast onset" patented technology

Provided are a new type of benzodiazepine compound, a preparation method thereof, and a use thereof. The short-acting benzodiazepine derivative has the characteristics of rapid onset, short action time, strong depth, fast metabolism, and fast awakening. In the anesthesia experiments on mice and rats, the short-acting benzodiazepine derivative has an onset time comparable to that of remazepam, but the action time and awakening time are significantly shortened, and the action depth of some compounds is significantly enhanced, and has the characteristics of faster onset, shorter action time, greater action strength, faster metabolism, and faster awakening. In the long-term infusion anesthesia experiment on rats, compared with remazepam, the short-acting benzodiazepine derivative has significantly shortened awakening time and recovery time, and has the characteristics of faster awakening and faster recovery.

The invention belongs to the technical field of anesthetic drugs, and particularly relates to an anesthetic drug and a preparation method thereof. The anesthetic is prepared by mixing 1000 parts by weight of bupivacaine liposome injection, 0.5-1 part by weight of magnesium sulfate and 3-5 parts by weight of dexmedetomidine hydrochloride. Wherein magnesium sulfate and dexmedetomidine hydrochloride are auxiliary agents, so that the anesthesia onset time is shortened. The anesthetic prepared by the invention is smaller in side effect, quick in effect taking and long in maintenance time, the injection frequency of the anesthetic can be reduced, the infection risk and the nursing cost can be reduced, the anesthetic effect is good, and the application prospect is wide.

The present invention provides a substituted tetrahydrofuran-formamide derivative, a salt or stereoisomer, a pharmaceutical composition containing same, a use thereof as a Nav inhibitor, and a use thereof in preparation of a drug for treating and / or alleviating pain and pain-related diseases. The compound provided in the present invention has the advantages of high metabolic stability, high oral absorption, better bioavailability, better activity, higher selectivity, better pharmacokinetic properties, faster onset of action, and low central nervous system side effects.

The invention provides a directionally-released nicotine oral soluble film, a preparation method thereof and an oral product. The preparation method comprises the following steps: S1, respectively preparing a first-layer film, a second-layer coating liquid and a third-layer coating liquid; s2, coating the first layer of film with a second layer of coating liquid, and performing vacuum drying to obtain a double-layer composite film; and S3, coating the double-layer composite film with a third layer of coating liquid, and drying to obtain a three-layer composite film. According to the three-layer composite structure, the hydrophobic substrate layer is used as a physical barrier, and the release path of nicotine is strictly limited in the single direction facing the oral mucosa; due to the directional release mechanism, the medicine utilization efficiency is greatly improved, and nicotine can be quickly absorbed through oral mucosa capillaries to enter systemic circulation, so that the onset speed exceeding that of a traditional transdermal patch is realized; and aiming at the inherent strong bitter taste of nicotine, the flavoring system compounded in the nicotine release layer can effectively cover bad taste, so that the sensory experience of the nicotine in the first mouth is improved.