38results about How to "Quick effect" patented technology

The application discloses a kind of cosmetics suitable for sensitive skin and preparation method thereof, preparation raw materials include A phase, B phase, C phase and D phase;The preparation raw materials of A phase include emulsifier, emollient, thickening agent, antioxidant;The preparation raw materials of B phase include water, humectant, chelating agent, thickening agent B;The preparation raw materials of C phase include emulsifier C, humectant C, plant extract;The preparation raw materials of the D phase include preservative.The application does not contain synthetic pigment, plastic micro powder, mineral oil and other harmful ingredients of skin, nature is mild, no stimulation, no toxic side effect, the subject is continuously used the cosmetic prepared by the application 28 days, and the decrease rate of lactic acid stinging score compared with base value is 50.38%, and product effect is remarkable, and effect is fast.

This invention discloses a traditional Chinese medicine composition for replenishing qi and nourishing blood, and its preparation method, belonging to the technical field of food-medicine homology traditional Chinese medicine health care preparations. The composition of this invention uses oyster peptide powder, compound amino acid powder, polygonatum powder, maca powder, eucommia male flower powder, ginseng powder, cordyceps powder, and earthworm protein peptide powder as core active ingredients, supplemented with deer antler powder, deer tendon powder, and deer blood peptide powder to enhance the effects of strengthening the body and nourishing blood. It is combined with xylitol, corn starch, maltodextrin, magnesium stearate, and caramel color as molding excipients. The dosage of each component is precisely controlled. Through a proprietary preparation process involving raw material pretreatment, segmented gradient mixing, and refined post-processing, a 1g / tablet formulation is prepared. The formulation of this invention is rigorously formulated, with clear distinctions between principal, assistant, and adjuvant ingredients, and each component synergistically enhances its effect. It can fundamentally improve problems such as qi and blood deficiency, insufficient vital energy, fatigue, and physical weakness. It has comprehensive efficacy, rapid onset of action, and wide applicability, possessing extremely high industrial promotion and health care application value.

The invention discloses a compound polysaccharide preparation for treating diabetes and application thereof, and belongs to the technical field of biomedicine. The compound polysaccharide preparation is composed of compound polysaccharide A and compound polysaccharide B according to the mass ratio of 1: 1. The compound polysaccharide A is prepared from abelmoschus esculentus and chlorella through alkaline ultrasonic extraction and 10-100kDa ultrafiltration classification; the compound polysaccharide B is prepared by performing enzymolysis and hot water extraction on grifola frondosa and sarcodon aspratus. Experiments prove that the preparation can significantly improve insulin secretion and glucose uptake ability of islet cells, effectively reduce fasting blood-glucose of type 2 diabetes model mice and synchronously improve triglyceride and total cholesterol levels through strong synergistic interaction among the components. The preparation disclosed by the invention is natural in source, safe and efficient, so that a new choice is provided for medicine development of type 2 diabetes mellitus.

The invention is suitable for the technical field of veterinary biological products, and provides a pasteurella egg yolk antibody for sheep and a preparation method thereof, and the preparation method comprises the following steps: S1, preparing an immunogen; s2, immunizing the hens; s3, crude extraction of an egg yolk antibody: separating egg yolk, collecting egg yolk liquid, adding a PBS buffer solution in proportion to fully dissolve the egg yolk, and standing and centrifuging to obtain a crude extract; s4, egg yolk antibody purification: precipitating the crude body fluid with an ammonium sulfate solution with the saturation degree of 38%, collecting antibody precipitate, dissolving with a PBS buffer solution, carrying out primary dialysis, then adding an ammonium sulfate solution with the saturation degree of 28%, carrying out secondary precipitation, and finally carrying out secondary dialysis to obtain a purified egg yolk antibody solution; and S5, antibody quality detection and split charging. The scheme has the advantages of comprehensive serotype coverage and strong protective force; the original animal is used for separating strains, so that the specificity is high; and the antibody has the advantages of high purity, low side reaction rate, quick response, no drug resistance, no residue and the like, and can be applied to prevention and treatment.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related oral mucositis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix rehmanniae recen, 6-12 parts of radix ophiopogonis, 6-12 parts of radix scrophulariae, 6-12 parts of honeysuckle, 6-12 parts of fructus forsythiae, 3-7 parts of radix scutellariae, 1-3 parts of lotus plumule, 3-7 parts of mint and 3-7 parts of borneol. The composition has the effects of nourishing yin, clearing heat, astringing sores and promoting tissue regeneration, and clinical tests prove that the composition can remarkably reduce the occurrence rate of chemotherapy-related oral mucositis of hematological malignancy patients, relieve the damage degree of oral mucosa, shorten the lasting time of ulcer and pain and effectively improve clinical symptoms of traditional Chinese medicine, and is high in safety.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention provides traditional Chinese medicine compound Tianyuantong granules which are prepared from the following raw materials by weight: 3-18g of gastrodia elata, 3-18g of ligusticum wallichii, 3-18g of radix angelicae, 2-12g of vinegar-processed rhizoma corydalis, 2-12g of moutan bark, 2-12g of fructus viticis, 2-12g of angelica sinensis, 6-24g of spina date seed, 3-18g of prepared radix morindae officinalis, 3-18g of rhizoma pinelliae preparata, 3-18g of herba patriniae, 3-18g of valerian, 3-18g of hypericum perforatum, 1-6g of blood amber and 10-40g of raw oyster. In the traditional Chinese medicine compound Tianyuantong granules, gastrodia elata is used as a monarch drug for calming liver and activating collaterals; ligusticum wallichii and dahurian angelica root lead medicines to move upwards, dispel wind and relieve pain, and serve as ministerial The corydalis tuber, the moutan bark and the fructus viticis promote qi circulation to relieve pain, and the angelica sinensis and the spina date seeds enrich and activate blood; prepared radix morindae officinalis and rhizoma pinelliae preparata have the effects of warming yang and reducing phlegm; the granule is a granular preparation with a certain granularity prepared from traditional Chinese medicine extracts and auxiliary materials, keeps the characteristics of high decoction absorption efficiency and quick effect, and is small in dosage.

The application discloses a multi-target synergistic composite essential oil composition, a nose inhalation stick and a preparation method thereof, relates to the technical field of aromatherapy and neuropharmacology, and the multi-target synergistic composite essential oil composition is composed of the following natural plant essential oils in percentage by weight, and the sum of the content of each component is 100%: 25-35% of true lavender essential oil; 15-25% of sweet orange essential oil; 10-18% of Roman chamomile essential oil; 8-15% of lemon verbena essential oil; 6-12% of bergamot essential oil; 5-10% of lemon essential oil; 3-8% of ylang ylang essential oil; 2-6% of clary sage essential oil; 1-3% of black pepper essential oil; 1-3% of sandalwood essential oil; and 0.5-2% of patchouli essential oil. The application is based on a clear neuropharmacological mechanism, and eleven kinds of essential oils are scientifically matched without dilution of base oil; a significant emotional relaxation effect is generated within 5-10 minutes of active sniffing; and the application has the auxiliary function of improving sleep difficulty.

The intranasal administration of 1, 3, 5 (10), 16-estratetraen-3-yl acetate may be used to improve mental motor and / or cognitive performance in mental fatigue subjects.

The application discloses a lung-targeted nanocomposite and a preparation method and application thereof, wherein the nanocomposite comprises carbon nitride two-dimensional nanosheets and AIE photosensitizers loaded on surfaces of the carbon nitride two-dimensional nanosheets. The nanocomposite has excellent aggregation-induced emission properties and active oxygen generation capacity, can play a diagnostic role of the photosensitizer, and can produce a better tumor elimination effect, so that the diagnosis and treatment of lung cancer can be simultaneously realized. In addition, the nanocomposite has a suitable size, can enhance the retention of drugs in the lung, prolong the treatment time, and reduce the administration frequency; the nanocomposite can also be administered through tracheal spray, has the advantages of rapid onset, high local drug concentration, small drug dosage, convenient use, less systemic adverse reactions, easy monitoring and adjustment of the dosage, and the like.

This invention discloses an emergency product and method for hypothermia protection in low-temperature environments, belonging to the field of hypothermia protection and emergency care. This invention is the first to apply triiodothyronine (T3) to the preparation of an emergency product for hypothermia protection in low-temperature environments, fully utilizing T3's ability to rapidly increase heat production in tissues such as brown adipose tissue, thereby enhancing the body's active heat production capacity. Combining the physiological metabolic characteristics of the human body with the pharmacological properties of T3, this invention has achieved excellent results in animal experiments. On the one hand, T3 can maintain the core body temperature of hypothermic experimental animals at a higher level for a longer period, resulting in increased swimming time and extending the golden time for rescue. On the other hand, it can effectively improve the recovery of body temperature after rescue, significantly increasing the success rate of treatment. However, when using T4, which is considered more effective in conventional clinical settings, no significant improvement in these two aspects was observed, fully demonstrating the specificity and superiority of T3.

The invention discloses an acupoint application for treating polycystic ovarian syndrome and a preparation and use method thereof. The acupoint application comprises a radix salviae miltiorrhizae acupoint application, a semen cuscutae-radix salviae miltiorrhizae acupoint application, a radix morindae officinalis-radix salviae miltiorrhizae acupoint application and a semen cuscutae-radix morindae officinalis acupoint application. The traditional Chinese medicine composition is prepared from salvia miltiorrhiza, semen cuscutae and salvia miltiorrhiza, morinda officinalis and salvia miltiorrhiza, and semen cuscutae and morinda officinalis. The invention further provides a preparation method of the acupoint application and an artificial cycle therapy using method. The acupoint application medicine cake has the advantages that the acupoint application medicine cake is mainly used for treating the polycystic ovarian syndrome, has the effects of tonifying the kidney, activating blood, removing stasis and promoting follicular maturation and ovulation, is convenient and safe to apply externally, can enhance the compliance of a patient, can be absorbed through peritoneal transdermal absorption, can avoid the first-pass effect of oral administration, is closer to a disease site in the administration position, and takes effect faster.

The application discloses a full-water-soluble, zero-residue, green and environment-friendly anti-drowsiness eye protection capsule, and belongs to the field of eye care and traffic safety protection. The capsule is made of full-water-soluble degradable materials, can be quickly melted in 3 seconds, can realize pure physical fumigation in 3 minutes, and can continuously provide a cooling effect for 2-3 hours, so that driving fatigue can be effectively relieved, the driver can be refreshed and the driving safety can be ensured. The application is free of electronics, instruments, batteries and heating, has a pure physical structure, is absolutely safe under sun exposure in a vehicle, cannot catch fire or explode, is gentle in components, and can be used by the old and the young, and after use, is free of residues, garbage and green and environment-friendly, and has the effects of eye protection, the value of traffic safety and the significance of ecological environmental protection.

This invention discloses an orally disintegrating film formulation of BPC-157 sodium salt for treating acute alcohol poisoning and its preparation method. It relates to the field of acute alcohol poisoning treatment technology. The orally disintegrating film formulation comprises, by weight percentage: 0.1-5% BPC-157 sodium salt, 40-70% film-forming material, 5-15% plasticizer, 0.1-15% disintegrant, 0.1-15% sweetener, 0.1-10% salivary stimulant, and 1-5% other excipients. This invention prepares an orally disintegrating film formulation of BPC-157 sodium salt, utilizing its rapid dissolution characteristics and the pharmacological effects of BPC-157, providing a new option for treating acute alcohol poisoning. This formulation has advantages such as rapid onset of action, high bioavailability, and few side effects, and is expected to become an effective drug for treating acute alcohol poisoning.

The invention relates to the technical field of traditional Chinese medicine, in particular to anti-inflammatory and analgesic external traditional Chinese medicine powder for osteoarthritis and a preparation method thereof, and the powder is prepared from the following raw materials in parts by weight: 6.7 parts of mirabilite, 2 parts of borneol, 1 part of fructus gardeniae, 0.7 part of rhizoma paridis, 0.7 part of radix aconiti, 0.7 part of radix aconiti agrestis, 0.6 part of caulis spatholobi, 1.3 parts of rheum officinale, 0.4 part of cassia twig and 0.6 part of radix achyranthis bidentatae. The preparation method comprises the following steps: weighing the medicinal materials according to the proportion, mixing, grinding at low temperature, controlling the temperature to be below 40 DEG C until uniform and fine powder is formed, and sieving, so as to obtain the traditional Chinese medicine powder. The powder has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness, and warming and activating meridians; the traditional Chinese medicine composition has the advantages of quick effect, exact curative effect, convenience in use and high safety on osteoarthritis (especially patients with red, swollen and heat pain symptoms). The preparation method is simple in process, easy to control and suitable for industrial production.

The application relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application thereof. The traditional Chinese medicine composition contains angelica sinensis, safflower, red peony root, salvia miltiorrhiza, radix aconiti kusnezoffii, radix aconiti carmichaeli, cassia twig, drynaria, radix rubi sylvestris, frankincense, myrrh, radix rubi sylvestris, natural copper, elderberry, radix curdlane, crab shell and zhangdan. The preparation method of the traditional Chinese medicine preparation comprises the following steps: mixing angelica sinensis, safflower, red peony root, salvia miltiorrhiza, radix aconiti kusnezoffii, radix aconiti carmichaeli, cassia twig, drynaria, radix rubi sylvestris, radix rubi sylvestris, natural copper, elderberry, radix curdlane and crab shell with vegetable oil to perform frying and boiling, performing solid-liquid separation to obtain medicine oil; mixing the medicine oil after being refined with zhangdan, frankincense and myrrh to obtain an ointment; soaking the ointment in water, taking out, heating and melting, mixing with blood ointment powder, and spreading. The traditional Chinese medicine composition and the traditional Chinese medicine preparation have the effects of setting bone, continuing tendon and relieving swelling and pain.

The present application belongs to the technical field of pharmaceutical chemistry, and particularly relates to a crystal form of lamivudine salt of m-hydroxybenzoic acid and a preparation method thereof. The crystal form has an X-ray diffraction spectrum expressed by 2theta using Cu-Kalpha radiation, and has characteristic peaks at least at 9.26+ / -0.2, 12.56+ / -0.2, 13.05+ / -0.2, 14.59+ / -0.2, 17.45+ / -0.2, 20.30+ / -0.2, 21.76+ / -0.2, 23.37+ / -0.2, 25.05+ / -0.2 and 27.58+ / -0.2; the crystal form is composed of a molecule of lamivudine, a molecule of m-hydroxybenzoic acid and a molecule of n-butanol as a basic unit; meanwhile, the crystal form has good solubility, provides ideal raw material for preparing parenteral dosage forms which are convenient to administer and have rapid effect, and thus better meets the requirements of clinical application.

This invention discloses a perampanel oral suspension and its preparation method. The preparation method of this invention includes the following steps: S1, adding microcrystalline cellulose sodium carboxymethyl cellulose co-treatment material to water for homogenization to obtain a first dispersion; S2, adding sorbitol, an antibacterial agent, and a pH adjuster to the first dispersion to obtain a second dispersion; S3, pulverizing perampanel and sieving it to control the particle size D. 90 The sample size is 10–15 μm; S4, the perampanel obtained in step S3 is subjected to antistatic treatment; S5, the perampanel treated in step S4, defoamer, and polyoxyethylene hydrogenated castor oil are added to the second dispersion to obtain the third dispersion; S6, water is added to the third dispersion to bring it to a final volume, and homogenization is performed to obtain the perampanel oral suspension. This method can significantly improve the dissolution rate, long-term stability, and control level of drug-related substances at day 0, and improve the uniformity of content.

This invention belongs to the field of pharmaceutical technology, specifically relating to the use of tropic acid and its derivatives in the preparation of drugs for treating immune and inflammation-related diseases, and to drugs for treating immune and inflammation-related diseases. The tropic acid and its derivatives are compounds of formulas I-IV or pharmaceutically acceptable salts thereof, as well as solvent compounds, enantiomers, diastereomers, tautomers, or mixtures thereof in any proportion, including racemic mixtures, of the compounds of formulas I-IV or pharmaceutically acceptable salts thereof. Animal studies show that tropic acid and its derivatives have broad-spectrum immunomodulatory, anti-inflammatory, and analgesic effects, significantly improving pathological indicators in numerous animal models of immune and inflammation-related diseases. They can regulate abnormal immune responses towards normalcy and exert good anti-inflammatory and analgesic effects, making them suitable for patients with different disease degrees and types of immune and inflammation-related diseases, and thus have industrial applications.

The invention discloses an application of sotrasturin, or a stereoisomer of sotrasturin, or a raceme of sotrasturin, or a pharmaceutically acceptable salt of sotrasturin, or a solvate of sotrasturin in the development of a medicine for preventing or treating TRPM8 related diseases. Particularly, sotratolin is disclosed as a TRPM8 agonist, and a good prevention or treatment effect can be obtained when sotratolin is used for preventing or treating xerophthalmia; in a mouse xerophthalmia model induced by a benzalkonium chloride solution, sotratoline has a remarkable improvement effect.

The invention belongs to the technical field of medicines, and particularly relates to a silybum marianum composition for improving liver function and a preparation method thereof, the composition comprises quick-release cholagogic micro powder and slow-release liver-nourishing particles in a mass ratio of 1: (2-4); the quick-release cholagogic micro powder is prepared from curcumin, fructus aurantii immaturus flavone, a tanshinone extract and PVP K30 through ball-milling solid dispersion; the slow-release liver-nourishing particle is of a core-shell structure, a freeze-drying core of the slow-release liver-nourishing particle contains silymarin and schizandrin extract, and a glycyrrhetinic acid-phospholipid / chitosan oligosaccharide targeted coating and a medicinal acrylic resin coating are sequentially arranged on an outer layer of the slow-release liver-nourishing particle. According to the composition, through sequential synergy of'first defibering and then repairing 'and a liver targeting effect, the content of silymarin in liver tissue is remarkably increased, the silymarin is retained for a long time, and liver function impairment such as non-alcoholic fatty liver disease is effectively improved.

The application discloses a potent non-sleepy antiemetic and anti-motion sickness pharmaceutical composition and application thereof, and belongs to the technical field of medicines.The composition comprises five active ingredients of pheniramine maleate, caffeine, vitamin B6, scopolamine and lidocaine.Through the synergistic effect of the components, the composition can strongly inhibit the dizziness and vomiting reaction caused by the vestibular stimulation, and meanwhile, the sedative effect of the antihistamine drug is antagonized by caffeine, so that the side effect of sleepiness of the traditional anti-motion sickness drug is avoided while the anti-motion effect is ensured.Experiments show that the effect of the composition in an anti-motion sickness animal model is obviously better than that of each single drug and a conventional positive control drug.The composition can be used for preparing various pharmaceutical preparations for preventing and treating motion sicknesses such as car sickness, ship sickness and aircraft sickness, and has important clinical application value.

The present application provides a kind of nintedanib solution for inhalation and preparation method and application, the inhalation solution includes active substance, solvent and auxiliary material, the single dose specification of the inhalation solution is 1-5ml, and the active substance in single dose specification is 2.41-12.04mg / ml nintedanib ethanesulfonic acid;The solvent is sterile injection solution water;The auxiliary material includes isotonicity regulator and pH regulator and can also include antioxidant;The addition amount of the isotonicity regulator is to make the inhalation solution have the weight molal osmotic concentration of 240-400mOsmol / kg;The addition of the pH regulator is to make the pH value of the inhalation solution preparation 3.0-4.0.The inhalation nintedanib solution of the present application can provide a kind of nintedanib for inhalation with convenient, safe and effective, and good stability of drug dosage form and drug delivery system in combination with liquid atomization device.

This invention discloses a melatonin / buspirone hydrochloride oral instant-dissolving film and its preparation method, belonging to the field of pharmaceutical technology. The preparation process of the melatonin / buspirone hydrochloride oral instant-dissolving film of this invention is as follows: Film-forming material is weighed, added to water, and stirred until fully swollen. Plasticizer, inclusion agent / solvent, melatonin, buspirone hydrochloride, crystallization inhibitor, opacifier, and flavoring agent are added sequentially, stirred until homogeneous, degassed, and a gel solution is obtained. This solution is then evenly coated onto a backing using a coating machine to form a film. After drying, the film is lifted and cut to the required size. The film of this invention is administered sublingually, allowing the drug to be directly absorbed into the bloodstream through the sublingual mucosa. It has a rapid onset of action, achieving both anxiety relief and quick sleep induction. The film does not require swallowing with water, making it convenient to use and suitable for children, the elderly, and patients with swallowing difficulties. Furthermore, the preparation process of this invention is simple, quick, and low-cost, offering good economic benefits.

This invention discloses a highly bioavailable ticagrelor solid dispersion, its formulation, preparation method, and application. The solid dispersion is prepared by hot melt extrusion of ticagrelor and a specific ternary carrier system, wherein the ternary carrier system is from Soluplus. ® The formulation consists of copovidone and hydroxypropyl methylcellulose. This solid dispersion is further combined with disintegrants, fillers, and lubricants to form a pharmaceutical composition. This invention utilizes the synergistic effect of a ternary carrier and hot-melt extrusion technology to ensure ticagrelor exists stably in an amorphous form, significantly improving drug dissolution and oral bioavailability. Experiments show that the formulation exhibits a dissolution rate ≥85% in pH 6.8 phosphate buffer after 30 min, and a relative bioavailability in beagle dogs reaching 150%–250% of commercially available tablets. It also demonstrates excellent stability, with no crystallization observed in a 6-month accelerated assay, indicating significant clinical value and market potential.

The application discloses cilostazol dextrophan sublingual tablets and a preparation method thereof. The application effectively solves the technical bottleneck that cilostazol cannot be quickly dissolved due to poor solubility by optimizing the types and proportions of excipients; and by creatively adding sodium bicarbonate and citric acid, the dual technical targets of 'fast dissolution + high hardness' are unexpectedly achieved, the bioavailability of cilostazol is significantly improved, and the drug effect of cilostazol can be quickly exerted within the golden treatment period of acute cerebral stroke. Meanwhile, the drug composition process is good in feasibility, the prepared sublingual tablets are excellent in disintegration performance, can adapt to the drug administration needs of patients with dysphagia, completely meet the clinical application and pharmaceutical quality standards, and have significant clinical value and industrialization potential.

The invention relates to an antibiotic-free biological fermentation compound feed for poultry and a preparation method thereof, and belongs to the technical field of feeds, the feed takes a fermentation basic raw material as a carrier, plant extracts and chemical addition components are added, and the synergistic effects of resisting bacteria, diminishing inflammation, regulating intestinal flora, promoting nutrient absorption and improving the immunity of poultry are achieved in a biological fermentation synergistic manner; and antibiotic residues are avoided, so that the safety of poultry products is guaranteed.

This invention belongs to the field of active ingredient extraction, specifically relating to a purslane extract screened using bioaffinity ultrafiltration, its preparation method, and its applications. This invention utilizes bioaffinity ultrafiltration to rapidly capture active small molecules that specifically bind to XOD from purslane extract, significantly shortening the screening cycle for natural product XOD inhibitors. Furthermore, the screened compounds have been verified in vitro to possess XOD inhibitory activity. The method exhibits high sensitivity and good reproducibility. This invention is the first to discover and clarify Ophiogonanone A, Cimidahurinine, and Cyanidin-3- O γ-glucoside is a natural XOD inhibitor found in purslane, providing a new natural candidate molecule for drugs that lower uric acid or treat gout.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., -CH2-, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.