56results about How to "Quick effect" patented technology

The invention belongs to the technical field of biological medicine, and provides an engineered extracellular vesicle, a preparation method, application and a drug for targeted repair of blood brain barrier in order to solve the technical problems that an existing repair tool takes effect slowly and is not enough in specificity, and the engineered extracellular vesicle is loaded with Wnt7a-K190A protein. After entering the brain, the engineered extracellular vesicle can be rapidly and specifically combined with a Gpr124 receptor to promote blood brain barrier repair, and in-vivo experiments verify that the engineered extracellular vesicle can promote blood brain repair, so that the engineered extracellular vesicle can be applied to preparation of targeted blood brain barrier repair drugs, becomes a supplement of existing tools, AAV, LNP and the like, and has a wide application prospect. Particularly, the high requirement on the treatment timeliness of central nervous system (injury irreversibility) diseases is met.

The tissue repair preparation at least comprises ECM, exosome and degradable glue, the ECM is an acellular matrix such as SIS, SIM and UBM, is granular and is injectable micro powder, and the content of the ECM is 10-50 mg / ml; the exosome is a healing-promoting cell, and is obtained by induction, polarization culture, centrifugation, supernatant collection and concentration and purification. The degradable glue is a polysaccharide with viscoelasticity; the advantages of a conventional filling agent are reserved, exosomes can be slowly released and internalized by various tissue cells, the activity of fibroblasts can be stimulated, the effect is lasting, and generation of new collagen is promoted; the defects of short effect and non-lasting effect of the existing filling agent are overcome; the product provided by the invention can achieve the effects of promoting rapid regeneration of collagen and maintaining for a long time; the functions of filling, face-lifting, tissue repairing and the like are achieved; the effect is remarkable, stable and lasting; the composition has multiple functions of quick effect, obvious effect and slow release and long-acting effect.

The invention relates to a solid orodispersible pharmaceutical dosing unit having a weight between 30 and 1000 mg, this dosing unit containing at least 100 µg of an estetrol component selected from estetrol, estetrol esters and combinations thereof; the solid dosing unit being obtainable by a process comprising the steps of: ⋅ providing an aqueous liquid comprising water, an estetrol component and optionally one or more other pharmaceutically acceptable ingredients; ⋅ mixing 1 part by weight of the aqueous liquid with 0.5 to 20 parts by weight of the carrier particles to produce wet particles; ⋅ removing water from the wet particles to produce charged particles; ⋅ optionally, mixing the charged particles with one or more tablet-making excipients;and to form the charged particles or mixture of charged particles and the tablet manufacturing excipient(s) in a solid dosing unit. The solid dosing unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.

The present application belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition and application thereof in preparation of an oral care product. The traditional Chinese medicine composition is prepared from 12-18 parts of Qingdai, 7-12 parts of raw gypsum, 7-12 parts of Huangqi, 9-15 parts of Gushugu, 3-7 parts of Honghuajiao, 3-7 parts of Baizhi, 6-10 parts of Fangfeng, 1-5 parts of Bajie, 6-10 parts of Huanylencao, 1-5 parts of Wuji, and 4-8 parts of Baiji as raw medicinal materials. The components of the composition are reasonably matched, and can realize multiple effects of analgesia, antibiosis, anti-inflammation, repair, and tooth fixation and health. The present application is suitable for all kinds of toothache patients, has a wide application range, a safe use mode, and a wide market application prospect.

The invention discloses an isoxazoline substituted picolinamide compound as well as a preparation method and application thereof. The isoxazoline substituted picolinamide compound has broad-spectrum and efficient insecticidal activity, is safe to non-target organisms, and is more beneficial to crop protection and environmental safety.

The application discloses a kind of cosmetics suitable for sensitive skin and preparation method thereof, preparation raw materials include A phase, B phase, C phase and D phase;The preparation raw materials of A phase include emulsifier, emollient, thickening agent, antioxidant;The preparation raw materials of B phase include water, humectant, chelating agent, thickening agent B;The preparation raw materials of C phase include emulsifier C, humectant C, plant extract;The preparation raw materials of the D phase include preservative.The application does not contain synthetic pigment, plastic micro powder, mineral oil and other harmful ingredients of skin, nature is mild, no stimulation, no toxic side effect, the subject is continuously used the cosmetic prepared by the application 28 days, and the decrease rate of lactic acid stinging score compared with base value is 50.38%, and product effect is remarkable, and effect is fast.

The invention provides a traditional Chinese medicine composition for treating children atopic dermatitis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials: 4-8 parts of rhizoma atractylodis, 6-10 parts of honeysuckle, 4-8 parts of cortex phellodendri, 4-8 parts of semen coicis, 4-8 parts of radix achyranthis bidentatae, 2-8 parts of radix sophorae flavescentis, 4-8 parts of cortex dictamni, 4-8 parts of fructus kochiae, 2-8 parts of cicada slough and The preparation method comprises the following steps: soaking the traditional Chinese medicinal materials in water, heating, refluxing, extracting, filtering and taking filtrate; concentrating the filtrate into clear paste, cooling, adding ethanol, standing, taking supernate, recovering ethanol, performing secondary concentration to obtain traditional Chinese medicine ointment, and granulating the traditional Chinese medicine ointment. The traditional Chinese medicine and modern pharmacological actions are combined to achieve the effects of clearing heat, eliminating dampness, tonifying spleen, excreting dampness, dispelling wind and arresting itching; in practical application, the traditional Chinese medicine composition has obvious improvement and cure conditions on children atopic dermatitis symptoms, and has the advantages of quick response, short curative effect, low side effect and no relapse after healing.

This invention discloses a traditional Chinese medicine composition for replenishing qi and nourishing blood, and its preparation method, belonging to the technical field of food-medicine homology traditional Chinese medicine health care preparations. The composition of this invention uses oyster peptide powder, compound amino acid powder, polygonatum powder, maca powder, eucommia male flower powder, ginseng powder, cordyceps powder, and earthworm protein peptide powder as core active ingredients, supplemented with deer antler powder, deer tendon powder, and deer blood peptide powder to enhance the effects of strengthening the body and nourishing blood. It is combined with xylitol, corn starch, maltodextrin, magnesium stearate, and caramel color as molding excipients. The dosage of each component is precisely controlled. Through a proprietary preparation process involving raw material pretreatment, segmented gradient mixing, and refined post-processing, a 1g / tablet formulation is prepared. The formulation of this invention is rigorously formulated, with clear distinctions between principal, assistant, and adjuvant ingredients, and each component synergistically enhances its effect. It can fundamentally improve problems such as qi and blood deficiency, insufficient vital energy, fatigue, and physical weakness. It has comprehensive efficacy, rapid onset of action, and wide applicability, possessing extremely high industrial promotion and health care application value.

The invention discloses a compound polysaccharide preparation for treating diabetes and application thereof, and belongs to the technical field of biomedicine. The compound polysaccharide preparation is composed of compound polysaccharide A and compound polysaccharide B according to the mass ratio of 1: 1. The compound polysaccharide A is prepared from abelmoschus esculentus and chlorella through alkaline ultrasonic extraction and 10-100kDa ultrafiltration classification; the compound polysaccharide B is prepared by performing enzymolysis and hot water extraction on grifola frondosa and sarcodon aspratus. Experiments prove that the preparation can significantly improve insulin secretion and glucose uptake ability of islet cells, effectively reduce fasting blood-glucose of type 2 diabetes model mice and synchronously improve triglyceride and total cholesterol levels through strong synergistic interaction among the components. The preparation disclosed by the invention is natural in source, safe and efficient, so that a new choice is provided for medicine development of type 2 diabetes mellitus.

The present application relates to a curcumin bisglucoside-containing anti-inflammatory acne-removing composition and application thereof, comprising the following components: curcumin bisglucoside, rosemary extract, phaeophyceae extract and willow bark extract, which can synergistically realize multiple effects of oil control, anti-inflammation, redness reduction, barrier repair, effectively avoid acne recurrence and acne mark residue, and the overall formula takes into account the efficiency and mildness, has the advantages of fast effect, good effect and mildness, and is suitable for various acne skin, even sensitive acne skin, and has a wide market application prospect.

The invention is suitable for the technical field of veterinary biological products, and provides a pasteurella egg yolk antibody for sheep and a preparation method thereof, and the preparation method comprises the following steps: S1, preparing an immunogen; s2, immunizing the hens; s3, crude extraction of an egg yolk antibody: separating egg yolk, collecting egg yolk liquid, adding a PBS buffer solution in proportion to fully dissolve the egg yolk, and standing and centrifuging to obtain a crude extract; s4, egg yolk antibody purification: precipitating the crude body fluid with an ammonium sulfate solution with the saturation degree of 38%, collecting antibody precipitate, dissolving with a PBS buffer solution, carrying out primary dialysis, then adding an ammonium sulfate solution with the saturation degree of 28%, carrying out secondary precipitation, and finally carrying out secondary dialysis to obtain a purified egg yolk antibody solution; and S5, antibody quality detection and split charging. The scheme has the advantages of comprehensive serotype coverage and strong protective force; the original animal is used for separating strains, so that the specificity is high; and the antibody has the advantages of high purity, low side reaction rate, quick response, no drug resistance, no residue and the like, and can be applied to prevention and treatment.

The present invention relates to anti-depression and anti-anxiety application of a polypeptide, and provides application of a polypeptide having a sequence as shown in SEQ ID NO: 1 in preparation of a medicine for treating and / or preventing depression or anxiety. The present invention further relates to a complex containing the polypeptide.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related oral mucositis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix rehmanniae recen, 6-12 parts of radix ophiopogonis, 6-12 parts of radix scrophulariae, 6-12 parts of honeysuckle, 6-12 parts of fructus forsythiae, 3-7 parts of radix scutellariae, 1-3 parts of lotus plumule, 3-7 parts of mint and 3-7 parts of borneol. The composition has the effects of nourishing yin, clearing heat, astringing sores and promoting tissue regeneration, and clinical tests prove that the composition can remarkably reduce the occurrence rate of chemotherapy-related oral mucositis of hematological malignancy patients, relieve the damage degree of oral mucosa, shorten the lasting time of ulcer and pain and effectively improve clinical symptoms of traditional Chinese medicine, and is high in safety.

The invention discloses an ALS inhibitor sulfonylurea herbicide as well as a preparation method and application thereof, relates to the technical field of herbicides, and comprises 22 compounds with structures as shown in a general formula I or optical isomers, crystal forms, pharmaceutically acceptable salts, hydrates or solvates thereof as well as a preparation method and application thereof. After the medicines are reasonably matched, the herbicide has a relatively good control effect on gramineae or broad leaf, and the herbicide disclosed by the invention does not cause harm to soil and environment.

The present application relates to a kind of dolasetron mesylate suppositories, it is characterized in that, component includes: dolasetron mesylate, cyclodextrin or its derivative, shell matrix, hardness regulator, gel matrix, water;The gel matrix includes polyacrylic acid derivative grafted chitosan in it.The present application uses polyacrylic acid derivative grafted chitosan and cyclodextrin to prepare dolasetron mesylate liquid gel, significantly improve the stability and bioavailability of suppository;And can achieve the purpose of quick effect and slow release long-acting simultaneously.The suppository of the present application is very convenient for old people, children or patients who cannot be administered orally, and the treatment population of the product belongs to the patient who is inconvenient to swallow.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The present invention relates to the field of pharmacy, and specifically discloses a dexmedetomidine hydrochloride soluble microneedle and a preparation method thereof. The dexmedetomidine hydrochloride soluble microneedle comprises a needle body and a substrate, and the needle body comprises dexmedetomidine hydrochloride and dextran. The present invention combines dexmedetomidine hydrochloride with dextran to form a soluble microneedle, which can achieve rapid drug release, and the onset time is the same as that of subcutaneous injection. At the same time, it also has a high bioavailability, and is a new treatment strategy that can replace subcutaneous injection. It is expected to be used for the sedative effect of children during preoperative examinations in the future, avoiding children's fear of injection needles, improving patient compliance, and also providing a possibility of rapid onset of microneedle transdermal administration.

The invention provides traditional Chinese medicine compound Tianyuantong granules which are prepared from the following raw materials by weight: 3-18g of gastrodia elata, 3-18g of ligusticum wallichii, 3-18g of radix angelicae, 2-12g of vinegar-processed rhizoma corydalis, 2-12g of moutan bark, 2-12g of fructus viticis, 2-12g of angelica sinensis, 6-24g of spina date seed, 3-18g of prepared radix morindae officinalis, 3-18g of rhizoma pinelliae preparata, 3-18g of herba patriniae, 3-18g of valerian, 3-18g of hypericum perforatum, 1-6g of blood amber and 10-40g of raw oyster. In the traditional Chinese medicine compound Tianyuantong granules, gastrodia elata is used as a monarch drug for calming liver and activating collaterals; ligusticum wallichii and dahurian angelica root lead medicines to move upwards, dispel wind and relieve pain, and serve as ministerial The corydalis tuber, the moutan bark and the fructus viticis promote qi circulation to relieve pain, and the angelica sinensis and the spina date seeds enrich and activate blood; prepared radix morindae officinalis and rhizoma pinelliae preparata have the effects of warming yang and reducing phlegm; the granule is a granular preparation with a certain granularity prepared from traditional Chinese medicine extracts and auxiliary materials, keeps the characteristics of high decoction absorption efficiency and quick effect, and is small in dosage.

The present invention relates to an environmentally friendly anti-skinning auxiliary agent and a preparation method thereof, and belongs to the technical field of water-based inks. The formula comprises modified chitosan oligosaccharides, polyether-modified polysiloxanes, polyvinyl alcohol, water-soluble malonate carbon quantum dots and deionized water as ingredients. Chitosan oligosaccharides have good water solubility due to their small relative molecular mass, and are easy to form a soft and uniform film layer, which effectively prevents ink from skinning and maintains wetness; by introducing chlorogenic acid, the antioxidant efficiency of chitosan oligosaccharides is significantly improved, while retaining its film-forming and moisturizing advantages. Polyether-modified polysiloxanes and polyvinyl alcohol jointly promote the rapid onset of ingredients, enhance stability and durability. The introduction of water-soluble malonate carbon quantum dots improves photostability and reduces photooxidation reactions. The auxiliary agent of the present invention has excellent anti-skinning efficiency, strong antioxidant properties and environmental protection, and most of the raw materials are derived from nature. No harmful solvents or catalysts are required in the preparation process, which conforms to the concept of green chemistry and is harmless to the environment and human health.

The application discloses a multi-target synergistic composite essential oil composition, a nose inhalation stick and a preparation method thereof, relates to the technical field of aromatherapy and neuropharmacology, and the multi-target synergistic composite essential oil composition is composed of the following natural plant essential oils in percentage by weight, and the sum of the content of each component is 100%: 25-35% of true lavender essential oil; 15-25% of sweet orange essential oil; 10-18% of Roman chamomile essential oil; 8-15% of lemon verbena essential oil; 6-12% of bergamot essential oil; 5-10% of lemon essential oil; 3-8% of ylang ylang essential oil; 2-6% of clary sage essential oil; 1-3% of black pepper essential oil; 1-3% of sandalwood essential oil; and 0.5-2% of patchouli essential oil. The application is based on a clear neuropharmacological mechanism, and eleven kinds of essential oils are scientifically matched without dilution of base oil; a significant emotional relaxation effect is generated within 5-10 minutes of active sniffing; and the application has the auxiliary function of improving sleep difficulty.

The intranasal administration of 1, 3, 5 (10), 16-estratetraen-3-yl acetate may be used to improve mental motor and / or cognitive performance in mental fatigue subjects.

The application discloses a lung-targeted nanocomposite and a preparation method and application thereof, wherein the nanocomposite comprises carbon nitride two-dimensional nanosheets and AIE photosensitizers loaded on surfaces of the carbon nitride two-dimensional nanosheets. The nanocomposite has excellent aggregation-induced emission properties and active oxygen generation capacity, can play a diagnostic role of the photosensitizer, and can produce a better tumor elimination effect, so that the diagnosis and treatment of lung cancer can be simultaneously realized. In addition, the nanocomposite has a suitable size, can enhance the retention of drugs in the lung, prolong the treatment time, and reduce the administration frequency; the nanocomposite can also be administered through tracheal spray, has the advantages of rapid onset, high local drug concentration, small drug dosage, convenient use, less systemic adverse reactions, easy monitoring and adjustment of the dosage, and the like.

The invention discloses an application of a pharmaceutical composition consisting of total glucosides of paeony and a non-steroidal anti-inflammatory drug in a transdermal drug delivery preparation. The application of the composition in a transdermal drug delivery preparation has the advantages that (1) the active epidermal barrier and the cuticle barrier of the skin are main barriers of transdermal absorption of total glucosides of paeony; the non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of the skin, and if the non-steroidal anti-inflammatory drug is matched with a penetration enhancer for opening the cuticle barrier of the skin, the transdermal permeability of the total glucosides of paeony in the transdermal drug delivery preparation can be remarkably improved; the method has the characteristics of simple preparation process, easiness in industrial production and non-invasive skin, and can safely and efficiently improve the percutaneous permeability of the total glucosides of paeony; and (2) the total glucosides of paeony and the non-steroidal anti-inflammatory drug in the transdermal drug delivery preparation are combined for use, so that the total glucosides of paeony and the non-steroidal anti-inflammatory drug have an obvious synergistic effect in the aspect of curative effect on primary dysmenorrhea and rheumatoid arthritis, and the curative effect is excellent.

This invention discloses an emergency product and method for hypothermia protection in low-temperature environments, belonging to the field of hypothermia protection and emergency care. This invention is the first to apply triiodothyronine (T3) to the preparation of an emergency product for hypothermia protection in low-temperature environments, fully utilizing T3's ability to rapidly increase heat production in tissues such as brown adipose tissue, thereby enhancing the body's active heat production capacity. Combining the physiological metabolic characteristics of the human body with the pharmacological properties of T3, this invention has achieved excellent results in animal experiments. On the one hand, T3 can maintain the core body temperature of hypothermic experimental animals at a higher level for a longer period, resulting in increased swimming time and extending the golden time for rescue. On the other hand, it can effectively improve the recovery of body temperature after rescue, significantly increasing the success rate of treatment. However, when using T4, which is considered more effective in conventional clinical settings, no significant improvement in these two aspects was observed, fully demonstrating the specificity and superiority of T3.

The invention discloses an acupoint application for treating polycystic ovarian syndrome and a preparation and use method thereof. The acupoint application comprises a radix salviae miltiorrhizae acupoint application, a semen cuscutae-radix salviae miltiorrhizae acupoint application, a radix morindae officinalis-radix salviae miltiorrhizae acupoint application and a semen cuscutae-radix morindae officinalis acupoint application. The traditional Chinese medicine composition is prepared from salvia miltiorrhiza, semen cuscutae and salvia miltiorrhiza, morinda officinalis and salvia miltiorrhiza, and semen cuscutae and morinda officinalis. The invention further provides a preparation method of the acupoint application and an artificial cycle therapy using method. The acupoint application medicine cake has the advantages that the acupoint application medicine cake is mainly used for treating the polycystic ovarian syndrome, has the effects of tonifying the kidney, activating blood, removing stasis and promoting follicular maturation and ovulation, is convenient and safe to apply externally, can enhance the compliance of a patient, can be absorbed through peritoneal transdermal absorption, can avoid the first-pass effect of oral administration, is closer to a disease site in the administration position, and takes effect faster.

The application discloses a full-water-soluble, zero-residue, green and environment-friendly anti-drowsiness eye protection capsule, and belongs to the field of eye care and traffic safety protection. The capsule is made of full-water-soluble degradable materials, can be quickly melted in 3 seconds, can realize pure physical fumigation in 3 minutes, and can continuously provide a cooling effect for 2-3 hours, so that driving fatigue can be effectively relieved, the driver can be refreshed and the driving safety can be ensured. The application is free of electronics, instruments, batteries and heating, has a pure physical structure, is absolutely safe under sun exposure in a vehicle, cannot catch fire or explode, is gentle in components, and can be used by the old and the young, and after use, is free of residues, garbage and green and environment-friendly, and has the effects of eye protection, the value of traffic safety and the significance of ecological environmental protection.

This invention discloses an orally disintegrating film formulation of BPC-157 sodium salt for treating acute alcohol poisoning and its preparation method. It relates to the field of acute alcohol poisoning treatment technology. The orally disintegrating film formulation comprises, by weight percentage: 0.1-5% BPC-157 sodium salt, 40-70% film-forming material, 5-15% plasticizer, 0.1-15% disintegrant, 0.1-15% sweetener, 0.1-10% salivary stimulant, and 1-5% other excipients. This invention prepares an orally disintegrating film formulation of BPC-157 sodium salt, utilizing its rapid dissolution characteristics and the pharmacological effects of BPC-157, providing a new option for treating acute alcohol poisoning. This formulation has advantages such as rapid onset of action, high bioavailability, and few side effects, and is expected to become an effective drug for treating acute alcohol poisoning.

The invention discloses an application of benzalkonium bromide and chlorhexidine in prevention and treatment of plant diseases, and discloses a benzalkonium bromide and chlorhexidine compound composition which has a relatively good synergistic effect in prevention and treatment of the plant diseases and has a very good application prospect.

The invention relates to the technical field of traditional Chinese medicine, in particular to anti-inflammatory and analgesic external traditional Chinese medicine powder for osteoarthritis and a preparation method thereof, and the powder is prepared from the following raw materials in parts by weight: 6.7 parts of mirabilite, 2 parts of borneol, 1 part of fructus gardeniae, 0.7 part of rhizoma paridis, 0.7 part of radix aconiti, 0.7 part of radix aconiti agrestis, 0.6 part of caulis spatholobi, 1.3 parts of rheum officinale, 0.4 part of cassia twig and 0.6 part of radix achyranthis bidentatae. The preparation method comprises the following steps: weighing the medicinal materials according to the proportion, mixing, grinding at low temperature, controlling the temperature to be below 40 DEG C until uniform and fine powder is formed, and sieving, so as to obtain the traditional Chinese medicine powder. The powder has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, relieving swelling and pain, dispelling wind and eliminating dampness, and warming and activating meridians; the traditional Chinese medicine composition has the advantages of quick effect, exact curative effect, convenience in use and high safety on osteoarthritis (especially patients with red, swollen and heat pain symptoms). The preparation method is simple in process, easy to control and suitable for industrial production.

The application relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition, a traditional Chinese medicine preparation, a preparation method and application thereof. The traditional Chinese medicine composition contains angelica sinensis, safflower, red peony root, salvia miltiorrhiza, radix aconiti kusnezoffii, radix aconiti carmichaeli, cassia twig, drynaria, radix rubi sylvestris, frankincense, myrrh, radix rubi sylvestris, natural copper, elderberry, radix curdlane, crab shell and zhangdan. The preparation method of the traditional Chinese medicine preparation comprises the following steps: mixing angelica sinensis, safflower, red peony root, salvia miltiorrhiza, radix aconiti kusnezoffii, radix aconiti carmichaeli, cassia twig, drynaria, radix rubi sylvestris, radix rubi sylvestris, natural copper, elderberry, radix curdlane and crab shell with vegetable oil to perform frying and boiling, performing solid-liquid separation to obtain medicine oil; mixing the medicine oil after being refined with zhangdan, frankincense and myrrh to obtain an ointment; soaking the ointment in water, taking out, heating and melting, mixing with blood ointment powder, and spreading. The traditional Chinese medicine composition and the traditional Chinese medicine preparation have the effects of setting bone, continuing tendon and relieving swelling and pain.