119 results about "Antibacterial action" patented technology

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

This invention provides a long-lasting antibacterial spray, its preparation method, and its application. The antibacterial spray comprises a polyphenol adhesion component, metal ions, auxiliary polyphenols, a network stabilizer, and water. The metal ions form a dynamically reversible coordination network with the polyphenol adhesion component; the metal ions include silver ions and zinc ions. In this invention, the silver nanoparticles may undergo surface oxidation or coordination dissociation processes in the polyphenol network environment, thus serving as a potential source of supplementary silver ions, contributing to a smoother ion release behavior and achieving long-lasting antibacterial action through ion-nano synergy. This invention utilizes the synergistic effect of silver and zinc ions to improve the physical stability of the system. By introducing a small amount of silver nanoparticles as "solid-phase nodes" in the polyphenol network, the structural stability and resistance to mechanical damage of the antibacterial system are improved without significantly increasing the total silver release.

The invention discloses an alpha-aminophosphoryl derivative as well as a preparation method and application thereof. The method comprises the following steps: by taking a quinoline derivative as a raw material and tetrahydrofuran (THF) as a solvent, adding boron trifluoride diethyl etherate in a nitrogen system at the reaction temperature of 0 DEG C, stirring for 15 minutes, reducing the temperature of the reaction system to T1 (-60 DEG C to-30 DEG C), adding a Grignard reagent into the reaction system, and reacting for 30 minutes to obtain a solution A; dissolving a phosphorus reagent in the organic solvent at room temperature in a nitrogen atmosphere to obtain a solution B; and adding the solution A into the solution B, reacting for 6-15 hours at the reaction temperature T2 (0-50 DEG C), and after the reaction is finished, extracting, concentrating and carrying out column chromatography to obtain the target product alpha-aminophosphoryl derivative. The invention provides a novel synthetic route for preparing the alpha-aminophosphonyl derivative, and various phosphorus reagents such as diaryl phosphorus oxide and phosphite ester can be compatible with the reaction. The alpha-aminophosphoryl derivative synthesized by the invention has a good antibacterial effect on gram-positive bacteria, especially staphylococcus aureus.

The invention belongs to the technical field of medical chemistry, and discloses a 5-O-carbon mould amine tylosin lactone derivative with a double-target combined antibacterial effect as well as a preparation method and application of the 5-O-carbon mould amine tylosin lactone derivative. The derivative is a compound as shown in a formula I, and pharmaceutically acceptable salt, eutectic, tautomer, polymorphic substance, solvate, prodrug or isotope labeled compound thereof. The compound can act on a bacterial ribosome 50S subunit and DNA topoisomerase IV at the same time, and shows an excellent antibacterial effect in an antibacterial activity test, and the minimum inhibitory concentration (MIC) reaches 0.0625 mu g / mL. The compound has the advantages of being high in antibacterial activity, wide in antibacterial spectrum and capable of achieving rapid sterilization, and a new choice is provided for developing drugs with antibacterial activity.

The invention relates to an application of a combined composition nanoparticle in preparation of a medicine for resisting fungal and bacterial infection. The active components of the combined composition nanoparticle are antibiotics and antibiotic adjuvants, the antibiotic adjuvant is tripterine or a pharmaceutically acceptable salt thereof. Compared with the prior art, the tripterine or the medicinal salt thereof and the antibiotics are prepared into the nanoparticles by utilizing a nanotechnology, so that the solubility of the fat-soluble antibiotics is effectively improved, the biocompatibility of the tripterine or the medicinal salt thereof is improved, and the tripterine or the medicinal salt thereof has an excellent effect in resisting fungal and bacterial infection. The tripterine or the medicinal salt thereof can enhance the antibacterial effect, especially the antifungal effect, of the antibiotics, increase the antibacterial sensitivity of the antibiotics and inhibit the occurrence of fungal or bacterial drug resistance.

The present application relates to the technical field of microbial pesticides, in particular to a deep-sea streptomyces with antifeedant function and antibacterial effect and application thereof. The streptomyces from the South China Sea deep sea is Streptomyces sp. NA13, which was preserved in China Center for Type Culture Collection on August 29, 2022, and the preservation number is CCTCC M 20221343. The strain has the ability to prepare antibiotics such as Antimycin, Candicidin, Naringenin, Surugamide, Fredericamycin, SAL-2242, Albaflavenone, Hopene, SGR PTMs, etc. In particular, the fermentation is used to prepare antimycin or cyclic octapeptide surugamide compounds, including novel antimycin compounds antimycin Q (1). The prepared antimycin compounds are used as insect pest antifeedants or antifungal drug lead compounds, and have application prospects of developing into natural source antibacterial and insecticidal pesticides.

The invention discloses a chitosan / lysozyme amyloid protein fiber composite microneedle based on ethephon controlled release and application of the composite microneedle in on-demand ripening acceleration of harvested fruits, and belongs to the technical field of agricultural product after-harvest treatment. The composite microneedle is composed of chitosan, lysozyme amyloid protein fibers and ethephon, the mass ratio of the chitosan to the lysozyme amyloid protein fibers is 5: 5, and the ethephon loading capacity is that 131.13 [mu] L of a 40% ethephon solution is added to every 17.5 mL of a 1% chitosan solution. The microneedle can be inserted into the epidermis of picked fruits to realize on-demand slow release of ethephon and promote ripening of the fruits, meanwhile, the lysozyme amyloid protein fiber provides an antibacterial effect, the aging process of the fruits after ripening is effectively delayed, the infection rate of colletotrichum gloeosporioides is reduced, and the ethephon residue in the fruits is remarkably lower than the national limited standard. The method solves the problems of non-uniform fruit ripening, excessive softening and potential toxicity caused by a traditional ethephon ripening method, and realizes integration of batch on-demand ripening and preservation of picked fruits.

This invention discloses a multi-target synergistic preservation method for fruits and vegetables based on the active ingredients of Torreya grandis aril, belonging to the field of fruit and vegetable preservation technology. The method includes the following steps: Step 1: Using Torreya grandis aril as raw material, Torreya grandis aril essential oil is extracted by steam distillation. This multi-target synergistic preservation method for fruits and vegetables based on the active ingredients of Torreya grandis aril combines four active ingredients—3-carene, D-limonene, δ-juniperol, and δ-juniperene—from the Torreya grandis aril essential oil with chitosan to construct an integrated synergistic preservation system of "antioxidant—enzyme inhibition—film protection—antibacterial action." This system protects the integrity of fruit cell membranes and delays softening and water loss, thereby overcoming the shortcomings of existing technologies that are single-function and unstable in effect. It achieves precise, multi-target intervention across the entire chain of postharvest physiological decline in perishable fruits and vegetables.

The invention relates to the technical field of natural product chemistry and cosmetics, and particularly discloses application of a composition containing a radix salviae miltiorrhizae extract in preparation of a product with an acne removing effect. The composition containing the radix salviae miltiorrhizae extract comprises the radix salviae miltiorrhizae extract and a calendula officinalis extract, the radix salviae miltiorrhizae extract is obtained by extracting with an ethanol water solution; the calendula officinalis extract is extracted by a carbon dioxide supercritical extraction method. Researches show that the composition containing the salvia miltiorrhiza extract, which is obtained by combining the salvia miltiorrhiza extract prepared by the method and the calendula officinalis extract, has a certain antibacterial effect on propionibacterium acnes. Therefore, the composition has important application value when being used as an active ingredient for preparing the medicine or the cosmetic with the acne removing effect.

The present invention relates to a method for treating Gram-negative bacteria that are resistant to colistin (MIC > 50 mg / mL), an antibacterial compound, excluding those of the genera Burkholderia, Proteus, and Serratia, comprising contacting the bacteria with an aqueous pharmaceutical composition containing a rose bengal (RB) compound of formula I, dissolved or dispersed at a concentration of about 0.01 to about 15 mg / mL, and irradiating the contacted bacteria with light of a wavelength of about 500 nm to about 600 nm for a period of about 1 to about 10 minutes, at a concentration of about 16 to about 160 J / cm². 2 The aim is to create a method that involves obtaining a certain amount of light to treat and kill irradiated bacteria. [Formula 1] JPEG2026511692000028.jpg5864 (where X, R 1 , R 2 (and M+ are defined herein)

The invention relates to the field of polypeptides, in particular to an NL-1 polypeptide capable of inhibiting a tight reaction and application of the NL-1 polypeptide. The NL-1 polypeptide is screened from transcripts of spiders, and the NL-1 polypeptide is predicted and verified to have antibacterial activity through antibacterial screening. An enzyme activity experiment is utilized to prove that synthesis of a tight reaction signal small molecule ppGpp can be reduced by inhibiting activity of key enzymes PaRelA and PaSpoT in a tight reaction of pseudomonas aeruginosa, so that the tight reaction is inhibited. Meanwhile, a bacteriostatic experiment and a bactericidal dynamics experiment prove that the NL-1 polypeptide grows in a concentration-dependent manner through three hospital-sourced multidrug-resistant pseudomonas aeruginosa strain; meanwhile, the NL-1 can effectively kill multidrug-resistant pseudomonas aeruginosa, in addition, the NL-1 also effectively reduces the generation of a quorum sensing key molecule PQS of the pseudomonas aeruginosa, and the component is proved to be related to antibiotic tolerance. In conclusion, the NL-1 polypeptide disclosed by the invention has a good antibacterial effect, can be used as a novel antibiotic, and has a huge application value for treatment of multidrug-resistant bacteria.

The invention belongs to the technical field of medicines, and particularly relates to application of IR808 in preparation of a medicine for treating eye bacterial infection diseases. According to the invention, IR808 is taken as a photosensitizer, laser irradiation is combined, and singlet oxygen generated by IR808 is utilized to play an antibacterial role. The developed eye drops, intraocular injections, sustained-release nanoparticles and gel preparations are designed aiming at the eye environment, and have good biocompatibility and stability. The treatment scheme in an animal model proves that pathogens including drug-resistant bacteria can be efficiently killed at low concentration, intraocular tissue damage caused by infection can be effectively relieved, and observable toxicity to intraocular cells and the whole body of an experimental animal is not shown. The invention provides a novel effective method for treating bacterial infection of eyes, especially for solving the drug resistance of antibiotics and improving the treatment safety.

The invention belongs to the technical field of biological medicines, and particularly discloses a nano drug-loaded catheter coating material based on TUBA1C gene expression regulation and a preparation method thereof. The coating material is composed of siRNA (small interfering ribonucleic acid) loaded with TUBA1C and PLGA (poly (lactic-co-glycolic acid)) / chitosan nanoparticles loaded with antibacterial peptide GL13K. The sequences of the siRNA are as shown in SEQ ID NO: 1 and SEQ ID NO: 2. Nanoparticles are prepared through a multiple emulsion-solvent evaporation method, and the surface of the catheter is coated with the nanoparticles. The coating provided by the invention can synergistically exert gene silencing and antibacterial effects, and siRNA silences a TUBA1C gene in urethral mucosa cells in a targeted manner and inhibits inflammatory response and fibrosis; the antibacterial peptide GL13K can kill pathogenic bacteria and prevent the formation of biological membranes. The coating material has antibacterial, anti-inflammatory and anti-biofilm functions, can effectively prevent and treat catheter-related urinary tract infection, and reduces the risk of long-term complications such as urethrostenosis.

This invention discloses a cation-cavity-dynamic covalent nanonetwork functional synergistic microring, its preparation method, and its application, belonging to the field of biomedical materials. The microring has an anisotropic ring structure with a positively charged inner wall and an environmentally responsive polyphenolic dynamic covalent nanonetwork grafted onto the outer wall. The inner wall enables electrostatic capture and physical confinement of bacteria, while the outer wall enables broad-spectrum adhesion and antibacterial effects, synergistically achieving integrated functions of capture, antibacterial, and anti-inflammatory. The preparation method uses polystyrene (PS) microspheres as seeds to obtain a Patchy template, which is then coated with silica, amino-functionalized, grafted with a dynamic covalent nanonetwork, and the template is removed and purified to obtain the target microring. The process is mild, the structure is uniform, and the biocompatibility is excellent. The microring of this invention has high capture and bactericidal efficiency against common clinical pathogens and significant antioxidant and anti-inflammatory effects. It can be used in the research and development of drugs for the treatment of bacterial infection-related inflammatory diseases, providing a novel carrier and technical direction for antibacterial and anti-infective biomedical materials.

The present application relates to the technical field of antibacterial drugs, and specifically discloses a pleuromutilin derivative and a use thereof, wherein the pleuromutilin derivative has a structure of being connected to a side chain of C14 of pleuromutilin by a mercaptoethylamine, piperazine or oxygen atom from a dihydroflavone or oxime ether derivative thereof. The present application introduces dihydroflavone (naringenin and hesperetin) and oxime ether derivatives thereof having antibacterial effects into the side chain of C14 of pleuromutilin by taking pleuromutilin as a raw material. The dihydroflavone and oxime ether derivatives thereof have great potential as an advantageous structural unit due to their unique C6-C3-C6 basic skeleton (C2 and C3 are single bonds) and extensive antibacterial activity. The dihydroflavone and oxime ether derivatives thereof are combined with pleuromutilin to synthesize a plurality of dihydroflavone pleuromutilin derivatives having excellent antibacterial activity. The present application provides a new choice for designing a new generation of pleuromutilin derivatives by a hybrid strategy, improving drug properties while improving activity, and providing an anti-infective drug.

The invention provides a no-wash antibacterial liquid for private parts and a preparation method of the no-wash antibacterial liquid. The mucous membrane repairing agent is prepared from the following raw materials in percentage by weight: 0.08 to 0.16 percent of polyhexamethylene biguanide hydrochloride, 0.9 to 1.9 percent of chitosan-lactoferrin-lactate grafted copolymer, 1.3 to 2.3 percent of sodium alginate coated nano zinc-plant prebiotic microcapsules, 0.1 to 0.3 percent of mucous membrane repairing agent, 1.2 to 2.2 percent of micro-ecological regulator, 2.8 to 5.2 percent of moisturizing soothing agent, 0.35 to 0.75 percent of thickening stabilizer, 1.4 to 2.8 percent of preservative, 0.6 to 1.4 percent of pH regulator, 1.2 to 2.6 percent of emulsifier and the balance of deionized water. According to the invention, all the components have a synergistic effect, and the safe and mild no-wash antibacterial liquid for the private parts, which has the functions of real-time bacteriostasis, lasting protection, mucous membrane repair and micro-ecological balance, is provided.

This invention relates to the field of fluorescent probe technology, specifically to a triphenylamine amphiphilic fluorescent probe, its preparation method, and its applications. The triphenylamine amphiphilic fluorescent probe is synthesized in three steps: bromination, coupling, and condensation to construct a D-π-A molecular structure, producing far-red light emission at 650-660 nm and exhibiting aggregation-induced emission (AIE) properties. The pyridine group endows it with hydrophilicity and cationic characteristics, while the triphenylamine group endows it with lipophilicity and AIE properties. It can specifically bind to bacterial surface anions, enabling wash-free, high-contrast real-time imaging, and can also disrupt bacterial biofilms to exert antibacterial effects. The probe has a MIC as low as 1.5625 μM against bacteria such as Staphylococcus aureus and Escherichia coli, can be co-stained with acridine orange for verification, is compatible with conventional detection equipment, and achieves integrated bacterial diagnosis and treatment, solving the problems of fluorescence quenching and low emission peaks in traditional probes.

This invention belongs to the field of aquatic product preservation technology and discloses a method for preserving fresh fish fillets based on source-based sterilization and endogenous antibacterial action. The method includes: non-thermal sterilization of fresh fish fillets, followed by ultrasonic-ultra-high pressure synergistic treatment in a nano-antibacterial emulsion, then draining, packaging, and refrigeration. The nano-antibacterial emulsion is prepared by dissolving natural antibacterial active substances in anhydrous ethanol as the oil phase and using an aqueous solution of a natural polymer as the aqueous phase. The oil and aqueous phases are mixed, homogenized under microfluidic high pressure, and then microfiltered. This invention utilizes a dual-core synergistic process of source-based non-thermal targeted inactivation of spoilage bacteria and enhanced penetration of a natural antibacterial system to significantly extend the shelf life of fresh fish fillets under 0-4℃ refrigeration conditions from the conventional 3-5 days to over 18 days, while preserving the texture, flavor, and nutrition of the fish fillets to the greatest extent possible.

The application belongs to the technical field of packaging materials, and particularly relates to a preparation method of an intelligent composite film with humidity regulating and antibacterial capabilities. The method uses hexamethylene diisocyanate, 2,6-pyridine dimethyl alcohol and 1,4-butanediol as raw materials to synthesize a humidity-sensitive polyurethane through a polycondensation reaction; the humidity-sensitive polyurethane is prepared into a humidity-sensitive film through a solution casting method; electrospinning is performed on the humidity-sensitive film as a substrate, and a polylactic acid nanofiber film loaded with an antibacterial active substance is compounded on the upper part of the humidity-sensitive film to form an electrospun layer with antibacterial function, thereby obtaining the intelligent composite film with humidity regulating and antibacterial capabilities. The intelligent composite film prepared by the application has a reasonable structure design and a mature and feasible manufacturing process, and effectively prolongs the shelf life of fruits, vegetables and other foods through the synergistic effect of humidity regulation and antibacterial action, and has a good application prospect.

This invention relates to the field of crystal materials technology, specifically disclosing a wear-resistant and antibacterial composite leather for electronic skin and its preparation method. The composite leather is composed of delimed bare leather, plant polyphenols, glutaraldehyde, lysine-chitosan graft polymer, tannic acid-zirconium coordination oligomer solution, plant-derived wax esters, and lipase. The preparation method includes: adding plant polyphenols and glutaraldehyde to the delimed bare leather for tanning to obtain primary cross-linked raw leather; adjusting the pH and then adding lysine-chitosan graft polymer and tannic acid-zirconium coordination oligomer for an antibacterial mineralization reaction; then adding plant-derived wax esters and lipase for an enzyme-catalyzed transesterification reaction; finally, drying, rehydrating, and softening to obtain the finished product. This invention, through the synergistic effect of multi-stage processes including composite tanning, synergistic antibacterial action, and enzyme-catalyzed lubrication, enables the composite leather to possess excellent wear resistance, long-lasting antibacterial properties, high breathability, and good softness, making it suitable for wearable devices such as electronic skin and showing promising application prospects.

The invention discloses a film coating method for the surface of a bearing disc. The film coating method comprises the steps that a transition layer is formed on the surface of the bearing disc; and forming a metal layer on the surface of the transition layer. According to the technical scheme, the metal protective film with the antibacterial effect is formed on the surface of the bearing disc, and the bearing disc does not need to be cleaned frequently, so that the problems of time, cost, environmental influence, labor conditions and the like caused by cleaning of the bearing disc can be solved.

This invention discloses a method for preparing a self-healing hydrogel with both sensing and antibacterial properties. The invention uses a hydrogel prepared from acrylamide (AM) and 2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA) and cellulose nanofibers (CNF) as a matrix, silver-coated polydopamine nanoparticles (Ag@PDA NPs) as antibacterial and conductive agents, and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylphenylacetone (I2959) and polyethylene glycol diacrylate (PEGDA) as photoinitiators and crosslinking agents. A multifunctional hydrogel with multiple dynamic reversible bonds is prepared by ultraviolet light-initiated self-polymerization. By constructing various dynamic reversible interactions, including covalent and non-covalent bonds and interionic interactions, a self-healing Ag@PDA NPs / AM / SBMA / CNF hydrogel was obtained. Ag and DA were introduced to prepare Ag@PDA with antibacterial, adhesive, and electronic conductivity properties, while zwitterionic SBMA was introduced to provide ionic conductivity. The synergistic effect of these two compounds endows the hydrogel with electrical conductivity. The hydrogel dressing prepared by this method can achieve rapid sterilization while possessing excellent biocompatibility, high adhesion, high conductivity sensing ability, and environmental adaptability.

The purpose of the present disclosure is to provide an absorbent article having excellent antibacterial action and excellent leak-proof performance.　An absorbent article (1) is provided with an absorbent body (27), the absorbent article (1) comprising: a pair of leak-proof walls (43) in which a leak-proof wall elastic member (45) is bonded to a hydrophobic sheet member (33) by a leak-proof wall bonding part (35) using a hot melt adhesive; a leak-proof wall overlapping region (47) that overlaps the pair of leak-proof walls (43) in a thickness direction (T) in a deployed state; an antibacterial composition (39) that contains a hydrophilic antibacterial agent and a hydrophilic and nonvolatile organic solvent; and an antibacterial composition arrangement region (41) that overlaps the antibacterial composition (39) in the thickness direction (T) in the deployed state. In the deployed state, the average basis weight of the antibacterial composition (39) in a longitudinal direction central region (51) and a width direction central region (55) is higher than the average basis weight of the antibacterial composition (39) in the longitudinal direction central region (51) and the leak-proof wall overlapping region (47).

The invention relates to the technical field of biological medicine, in particular to an NIR-II small-molecule compound with a photo-thermal antibacterial effect and a preparation method and application thereof.According to the D-A-pi-D type NIR-II small-molecule compound, furan or thiophene is introduced to a benzothiopyranium parent nucleus to serve as a pi bridge, a triphenylamine group serves as an electron donor, and the NIR-II small-molecule compound with the photo-thermal antibacterial effect is obtained through synthesis of the D-A-pi-D type NIR-II small-molecule compound with the photo-thermal antibacterial effect. The small molecule fluorescence imaging capability and the molar extinction coefficient of the D-A-pi-D type compound can be effectively improved, so that relatively high photothermal conversion efficiency is achieved. Especially, after the compound I6 is irradiated by 808nm laser, the photothermal conversion rate is the maximum and reaches 61.3%. In photo-thermal antibacterial treatment, deep penetration and local precise heating characteristics of NIR-II photo-thermal can be utilized to quickly destroy drug-resistant bacteria and biological membrane structures thereof, so that effective sterilization is realized. Therefore, the NIR-II small molecule compound prepared by the invention can be applied to the field of antibacterial medicines.

The present invention relates to: an antisense oligonucleotide (ASO) targeting an FKS1 gene, an FKS2 gene, a CHS3 gene and / or a GWT1 gene of a Candida sp. fungus; an antibacterial composition comprising same; and a pharmaceutical composition for preventing or treating diseases caused by pathogenic fungi. The ASO according to the present invention can be used as a gene therapeutic agent having a fungus-specific antibacterial effect by specifically inhibiting FKS1, FKS2, CHS3 and / or GWT1 genes, and can be a useful gene therapeutic agent that can be used in combination with or replace conventional antifungal agents for antifungal agent-resistant fungi or multidrug-resistant fungi.

The invention relates to a wound surface treatment agent and a preparation method thereof, and relates to the technical field of medical instruments, polyvinylpyrrolidone (PVP) is adopted to carry out organic molecule inclusion and stabilization on chlorine dioxide, so that chlorine dioxide keeps a dissolved state and chemical stability in a physiologically compatible weakly alkaline solution, and can be directly used without acidic activation; therefore, chemical stimulation of acid to the wound surface is avoided. When the stable system is in contact with wound exudate, the stable system can gradually release chlorine dioxide molecules with strong oxidation activity under the action of a body fluid ion environment, and a broad-spectrum and efficient antibacterial effect is locally played on a wound. Meanwhile, the released chlorine dioxide can promote the local blood coagulation process through the oxidation effect, and the healing process is facilitated. On the basis, the comprehensive performance is further enhanced through dosage form design, the effects of rapidly astringing wounds, reducing infection and promoting healing are achieved, and meanwhile the skin wound dressing is suitable for nursing skin wounds with different characteristics.

The invention discloses an application of lactobacillus plantarum RT1 with an antibacterial effect. The lactobacillus plantarum RT1 disclosed by the invention has excellent acid-resistant and cholate-resistant characteristics and broad-spectrum and efficient antibacterial action, can be used as a novel efficient antibacterial probiotic candidate, and is applied to the development of food preservatives, functional foods (such as fermented milk and probiotic solid beverages), feed additives and health-care products related to intestinal health; and a new microbial resource is provided for solving the problem of intestinal flora imbalance caused by food spoilage and antibiotic abuse.

This invention provides a water-contact polymer component, a water purification assembly, and a water purification system, relating to the field of water treatment technology. The water-contact polymer component has an antibacterial polymer layer covalently grafted onto its substrate surface; this antibacterial polymer layer contains antibacterial functional groups selected from quaternary ammonium salt groups and / or imidazole salt groups. The component provided by this invention, with its substrate surface covalently grafted with a polymer layer containing quaternary ammonium salt or imidazole salt groups, secures positively charged antibacterial groups through strong chemical bonds, achieving non-release, long-lasting antibacterial action that does not detach or precipitate, thus eliminating the risk of secondary pollution. Simultaneously, this structure utilizes a highly efficient contact sterilization mechanism to continuously and actively kill bacteria attached to the surface, completely eradicating the safety hazards of microbial proliferation and biofilm formation in stagnant water from the source.

The invention relates to an immunoregulation multifunctional surface modified TC4 material and a preparation method thereof, and belongs to the technical field of bone implant materials. Preparing a periodic microgroove structure with specific width and depth on the surface of the TC4 material by using a femtosecond laser processing technology; then, soaking the sample into a Tris-HCl buffer solution containing dopamine, and polymerizing to generate polydopamine; then putting the mixture into an absolute ethyl alcohol solution containing 4-octyl itaconic acid; and finally, obtaining the TC4 medical bone implant material with bone immunization, bone integration and antibacterial effects.

The application provides an amphiphilic nobeliatin molecule, a preparation method thereof and a blood glucose lowering and antibacterial application to a diabetic wound. The application relates to the technical field of biomedical materials. The application synthesizes a novel amphiphilic nobeliatin molecule by taking 1-deoxynobeliatin as a hydrophilic part and an alkyl chain as a hydrophobic part. The compound can self-assemble into a cluster sugar molecule in an aqueous solution, has good blood glucose lowering activity through the "multivalent effect" of the cluster sugar-glycosidase, has good antibacterial activity through the tertiary amine structure of the azasugar molecule and the long alkyl chain and the bacterial membrane, and realizes the compatibility of the blood glucose lowering effect and the antibacterial effect. The synthesis raw material of the nobeliatin molecule provided by the application is rich in source, low in price, simple in preparation process and convenient for industrial application. Therefore, the discovery of the compound is expected to provide a promising treatment scheme for the development of blood glucose lowering and antibacterial integrated materials and the treatment of diabetic wounds, and has a wide potential application field.