71 results about "Functionalized nanoparticles" patented technology

The invention provides a method for optimizing the mechanical property of a bio-based composite material based on nano modification, and belongs to the technical field of high-molecular compound compounds.The method includes the steps that wood flour is subjected to silane coupling agent modification pretreatment, a functionalized nano particle dispersion liquid is prepared, the dispersity is evaluated through a graph theory model, and the mechanical property of the bio-based composite material is optimized. The modified wood flour and polyethylene are subjected to melt blending in a twin-screw extruder in proportion, the functionalized nanoparticle dispersion liquid is synchronously added, real-time regulation and control are performed by using an intelligent dispersion optimization model, and the network structure integrity is evaluated through gridding performance indexes. The tensile strength, the bending strength and the impact strength are comprehensively optimized by adopting a multi-objective optimization game model, the process parameters such as the nano-particle addition amount, the mixing temperature and the mixing time are adjusted according to the optimization result, and the optimization is repeated until the preset target values are reached, so that the problems that the nano-particles are non-uniformly dispersed, local stress concentration points are formed, and the stability of the nano-particles is improved are solved. The overall mechanical property is influenced.

The invention discloses an ultra-stable anti-bioadhesion coating as well as a preparation method and application thereof, and belongs to the technical field of functional materials. The coating provided by the invention comprises a component A and a component B, the component A comprises nanoparticles, carboxyl silicone oil, a silane coupling agent and a solvent; the component B comprises a base material and a solvent; the nano-particles comprise at least one of silicon nano-particles, iron nano-particles or zinc nano-particles; the base material comprises epoxy resin. Through cooperation of the component A and the component B, the carboxyl silicone oil and the functionalized nanoparticles are combined and embedded into a matrix material, the formed coating can be used for preparing an ultra-stable anti-bioadhesion coating, the stability is good, the durability is good, adhesion of blood components, protein, bacteria, cells and the like can be effectively reduced, and the anti-bioadhesion performance of the coating is improved. The coating and the coating prepared from the coating have good application prospects in implantable medical equipment.

This disclosure relates to polyethylene glycol (PEG)-functionalized nanoparticles comprising a functional agent, and preparation methods, properties and applications thereof. The nanoparticle represented by PEG-L-G / P, comprising a type of hydrophilic PEG, a hydrophobic functional agent G, which are covalently linked by L: a linker or a chemical bond, and a type of hydrophobic polymer P. The G and P form the hydrophobic core, while the PEG constitutes the hydrophilic outer layer of the nanoparticle in an aqueous medium. The functional agent comprises one or more functional compounds including a therapeutic drug, an imaging diagnostic agent, a photoelectric responsive diagnostic agent, an immune-stimulating agent, or a combination thereof. The nanoparticles comprising such functional agent can offer various applications in multiple biomedical fields.

The invention relates to the technical field of soil science, and discloses a loess plateau special soil-based mine ecological restoration modifier which is prepared by the following steps: mixing a biological material and an inorganic material to form a biological-physical compound; inoculating specific microorganisms which are subjected to multi-layer packaging into the compound; organic matters and inorganic matters are fixed by utilizing a cross-linked polymer network to form a multi-layer structure; performing intelligent responsive coating treatment on the modifier particles; the prepared modifier is subjected to laboratory and field tests to verify the adaptability and effect of the modifier, and the biological-physical compound is prepared by mixing a local organic material with a certain water content with nano-modified bentonite according to a mixing ratio of 3: 1. By integrating the functionalized nanoparticles, a microbial packaging technology and an intelligent responsive coating, the soil water-retaining property, the nutrient utilization rate and the biological diversity are improved. The design ensures the stability and the lasting effect in an extreme environment, and meanwhile, continuous and efficient ecological restoration is realized.

The invention discloses a near-infrared organic fluorescent dye with mechanical responsiveness, and relates to the technical field of organic fluorescent dyes, the near-infrared organic fluorescent dye with mechanical responsiveness is prepared through seven-step reaction, an intermediate M1 containing a hydroxyl active end is firstly prepared, then intermediates M2, M3 and M4 are obtained through multi-step reaction, a target dye is obtained after purification, and finally surface functionalized nano-particles are self-assembled, so that the near-infrared organic fluorescent dye with mechanical responsiveness is obtained. The preparation method has the advantages that by designing a conjugate regulation and control structure of a rigid chromophore core and a flexible bridging unit, a mechanical response group is directionally grafted to the tail end of the flexible bridging unit through a CuAAC click chemical reaction; the problems of low fluorescence quantum yield and high response threshold caused by conjugation conflict of a traditional mechanical response group and a near-infrared chromophore are solved, the mechanical response threshold is reduced to a low stress range required by biomechanical detection, collaborative optimization of mechanical responsiveness and near-infrared fluorescence performance is realized, and the method is suitable for the fields of high-sensitivity biological stress monitoring and the like.

This disclosure relates to polyethylene glycol (PEG) -functionalized nanoparticles comprising a functional agent, and preparation methods, properties and applications thereof. The nanoparticle represented by PEG-L-G / P, comprising a type of hydrophilic PEG, a hydrophobic functional agent G, which are covalently linked by L: a linker or a chemical bond, and a type of hydrophobic polymer P. The G and P form the hydrophobic core, while the PEG constitutes the hydrophilic outer layer of the nanoparticle in an aqueous medium. The functional agent comprises one or more functional compounds including a therapeutic drug, an imaging diagnostic agent, a photoelectric responsive diagnostic agent, an immune-stimulating agent, or a combination thereof. The nanoparticles comprising such functional agent can offer various applications in multiple biomedical fields.

The invention provides a nitrogen-containing boric acid ester-nano hybrid composite anti-wear additive as well as a preparation method and application thereof, and belongs to the technical field of lubricating oil additives. The nitrogen-containing boric acid ester, the functionalized nanoparticles, the ionic liquid, the auxiliary anti-wear agent and the dispersion stabilizer are subjected to nano-scale hybrid compounding, and the nitrogen-containing boric acid ester, the functionalized nanoparticles, the ionic liquid, the auxiliary anti-wear agent and the dispersion stabilizer have a synergistic effect on four aspects of physical bearing, chemical adsorption, interface modification and extreme pressure enhancement; a multi-synergistic lubrication and protection system of an adsorption film, a physical isolation layer, an extreme pressure reaction layer and rolling lubrication microspheres is constructed, efficient wear resistance, friction reduction, bearing and stability improvement are jointly achieved, and the lubricating oil is suitable for insoluble base oil.

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

This invention relates to the field of holographic polymer-dispersed liquid crystal materials technology, providing liquid crystal functionalized nanoparticles, their preparation method, and materials. The liquid crystal functionalized nanoparticles include a nanoparticle core, a surface-modified layer bonded to the nanoparticle core, and a liquid crystal functionalized layer bonded to the surface-modified layer. Advantages: Liquid crystal transformation is achieved by chemically bonding small-molecule liquid crystal building blocks to the nanoparticles. By limiting the types of liquid crystal building blocks, the compatibility between the nanoparticles and the HPDLC system is improved, effectively solving the aggregation problem of traditional nanoparticle-doped HPDLC. Furthermore, this invention utilizes the inductive effect of the liquid crystal building blocks bonded to the nanoparticles and the high diffusion coefficient of the small-molecule liquid crystal building blocks, combined with the chemical potential gradient driving the holographic photopolymerization process and the excellent compatibility between the nanoparticles and the liquid crystal, to achieve directional enrichment of nanoparticles into liquid crystal microregions, further improving phase separation regularity.

In a method of preparing a flow cell, a slot die coater is used to introduce a nanoparticle suspension at a continuous flow rate to a substrate surface including depressions separated by interstitial regions, which generates a layer of the nanoparticle suspension at a stable concentration across the substrate surface. During the introduction of the nanoparticle suspension, at least some functionalized nanoparticles within the layer respectively enter at least some of the depressions. An excess amount of the layer is removed from the interstitial regions.

The invention belongs to the technical field of oil-based super lubrication, and particularly relates to a construction method of super-lubrication low-viscosity polar polyether modified silicone oil. The preparation method comprises the following steps: reacting allyl polyether with hydrogen-containing silicone oil according to a mass ratio of (70-80): 1 under the catalytic condition of chloroplatinic acid to obtain low-viscosity polar polyether modified silicone oil, and mixing 0.5 wt.%-1.5 wt.% of a polar additive, 0.1 wt.%-0.5 wt.% of surface functionalized nanoparticles and 97.5 wt.%-99.4 wt.% of the low-viscosity polar polyether modified silicone oil according to mass percent to obtain the compound lubricating oil. Performing ultrasonic treatment on the composite lubricating oil, and standing to obtain the super-lubricating low-viscosity polar polyether modified silicone oil. The polar additive molecules and the small-size and easy-to-disperse functional nanoparticles are compounded at the same time, so that the interaction between a lubricating film and a friction surface is remarkably enhanced in a cross-scale manner, and a friction pair motion interface is promoted to form a friction composite film with high bearing and low shearing characteristics; and stable ultralow friction and abrasion under the working conditions of wide rotating speed and wide load are achieved, and theoretical and technical supports are provided for engineering application of the oil-based super-lubrication technology.

The invention relates to the technical field of nano-drugs, and particularly discloses a preparation method and application of functionalized nano-selenium. According to the preparation method of the functionalized nano-selenium G2 / PAHCit / SeNPs, the functionalized nano-selenium G2 / PAHCit / SeNPs is prepared by taking G2, PAH-Cit and SeNPs as raw materials. Researches show that the functionalized nano-selenium has a stronger angiogenesis inhibition effect than a commercial drug suramine. Besides, the functionalized nano-selenium disclosed by the invention not only can effectively transfer the functionalized nano-particles to a target spot and maximally improve the transfer efficiency of the medicine to cause less tissue damage, but also can realize the effect of efficiently treating the lung cancer by virtue of the excellent biological activity of the nano-material. Particularly, the functionalized nano-selenium G2 / PAHCit / SeNPs disclosed by the invention has potential application values on lung related diseases including inhibition of lung vascular endothelial cell proliferation and inhibition of lung cancer tumor cell proliferation, and a nano-drug design idea is developed.

A method of recovering a product-of-interest from a plant or algal cell and a kit relating to the same are provided. The method of recovering a product-of-interest from a plant or algal cell includes (a) culturing a plant or algal cell that produces a product-of-interest in a culture medium; (b) adding functionalized nanoparticles to the culture medium, whereby the nanoparticles enter the plant or algal cell, bind the product-of-interest, and are extruded into the culture medium; (c) recovering the extruded nanoparticles from the culture medium; and (d) separating the product-of-interest from the extruded nanoparticles. The kit includes a plant or algal cell that produces a product-of-interest when in culture and a functionalized nanoparticle. Also provided is a method of separating plant or algal cells.

The present invention relates to functionalized nano- or microparticles of suitable size and shape, comprising a nano- or microparticle and at least one virus-binding peptide and / or virus-binding small molecule immobilized onto the surface of the nano- or microparticle. These nano- or microparticle forms aggregates with targeted viral particles to initiate phagocytosis, thereby achieving viral clearance. The present invention further relates to uses of the functionalized nano- or microparticles in virus detection, therapy and diagnosis.

The present invention is in the field of pre-functionalized nanoparticles (NPs). It more particularly relates to the use of NPs pre-functionalized with self-assembled monolayers (SAMs), and also to the use of NPs functionalized with biomolecules, such that the NPs are stable in solution. These NPs can be used in a variety of applications, in particular as diagnostic tools, depletion tools of target molecules in solution, and therapeutic tools.

The application belongs to the technical field of water treatment, and particularly relates to a reverse osmosis membrane scale inhibitor and application thereof. The reverse osmosis membrane scale inhibitor provided by the application comprises a macromolecular scale inhibitor, modified nanoparticles, tartaric acid, ethylenediaminetetraacetic acid and water. The application adopts the macromolecular scale inhibitor and the modified nanoparticles to be compounded as main components of the reverse osmosis membrane scale inhibitor, and adopts the tartaric acid and the ethylenediaminetetraacetic acid as auxiliary scale inhibition components, so that the scale inhibition effect of the reverse osmosis membrane scale inhibitor is effectively improved. The macromolecular scale inhibitor is synthesized by taking acrylic acid, allyl benzene sulfonic acid and N-hydroxymethyl acrylamide as monomers, so that the scale inhibition performance is improved, and the scale inhibitor itself is prevented from being precipitated. The 2-acrylamide-2-methylpropane sulfonic acid is grafted on the amino-functionalized nanoparticles, so that the normal growth of a crystal is destroyed through electrostatic repulsion and steric hindrance effect, and the scale inhibition performance of the reverse osmosis membrane scale inhibitor is improved.

The present invention relates to the field of prefunctionalized nanoparticles (NPs). More particularly, the present invention relates to NPs prefunctionalized with self-assembled monolayers (SAMs) and functionalized with biomolecules such that the NPs are stable in solution. These NPs can be used in many applications, particularly as diagnostic tools, tools for depleting molecules of interest in solution, and therapeutic tools.

The invention relates to a preparation method of a nano-composite microbial agent for efficiently removing kitchen waste grease. Pseudomonas, alcaligenes, bacillus and candida which have high grease degradation capacity are screened out from grease polluted water and kitchen waste compost, and the proportion of the pseudomonas, the alcaligenes, the bacillus and the candida is optimized to form the efficient composite flora. The preparation method comprises the following steps: synthesis of the magnetic Fe3O4 nanoparticles, surface functionalization treatment and synthesis and immobilization of the complex microbial inoculant. The stable and efficient nano-composite microbial agent is prepared by combining the functionalized nano-particles with the composite flora. Experimental verification shows that the complex microbial inoculant shows excellent stability and degradation performance in the application of removing kitchen waste grease, and can be repeatedly used through a magnetic separation technology. Compared with a traditional method, the method has the advantages that the grease removal efficiency is improved, the treatment cost is reduced, and the method has a wide application prospect.

A method of stimulating a subterranean formation includes preparing an aqueous dispersion including one or more cellulosic nanoparticles. The cellulosic nanoparticles have respective surfaces functionalized with one or more hydrophilic polymers or ligands, one or more hydrophobic polymers or ligands, or a combination thereof. The method also includes pumping the aqueous dispersion into the subterranean formation.

Amine functionalized nanoparticles comprising a core-shell nanoparticle morphology comprising a trialkoxyorganosilane coated nanoparticle core and an amine functionalized group on the surface of the nanoparticle as a shell are disclosed, wherein the nanoparticle has an average particle size from about 1 nm to about 1000 nm. Methods and applications of use of the amine functionalized nanoparticles and compositions comprising the amine functionalized nanoparticles dispersed in an aqueous medium are also disclosed.

The invention belongs to the technical field of water treatment, and particularly relates to a reverse osmosis membrane scale inhibitor and application thereof. The reverse osmosis membrane scale inhibitor provided by the invention comprises a macromolecular scale inhibitor, modified nanoparticles, tartaric acid, ethylenediamine tetraacetic acid and water. The macromolecular scale inhibitor and the modified nanoparticles are compounded to serve as main components of the reverse osmosis membrane scale inhibitor, and tartaric acid and ethylenediamine tetraacetic acid serve as auxiliary scale inhibition components, so that the scale inhibition effect of the reverse osmosis membrane scale inhibitor is effectively improved; acrylic acid, allylbenzenesulfonic acid and N-hydroxymethyl acrylamide are used as monomers to synthesize the macromolecular scale inhibitor, so that the scale inhibition performance is improved, and the scale inhibitor is prevented from self-precipitation; 2-acrylamide-2-methylpropanesulfonic acid is grafted on amino-functionalized nanoparticles, normal growth of crystals is destroyed through electrostatic repulsion and steric hindrance, and the scale inhibition performance of the reverse osmosis membrane scale inhibitor is improved.

Methods and apparatuses, including systems, for forming mycelium fabrics, manufacturing and / or production in large-scale mushroom farm facilities (e.g., commercial scale under an agroecological approach). These methods and apparatuses may allow the scaling-up of manufacturing of mycotextiles in a manner that is both cost-effective and respectful of the environment, including minimizing the production of harmful byproducts. These methods and apparatuses include adding a stabilized formulation containing growth inducers and functionalized nanoparticles to allow both fungal mycelium growth and in situ and in vivo nanocrosslinking.

The invention relates to the technical field of medicine, in particular to an antigen double burst release self-boosting immune vaccine and application thereof.The antigen double burst release self-boosting immune vaccine is characterized in that antigens are loaded inside and outside complex coacervation microcapsules in the vaccine, nanoparticles are prepared through a nanoprecipitation method, the nanoparticles and cell membranes jointly entrap the antigens to form functional nanoparticles, and the functional nanoparticles are used as functional nanoparticles; the preparation method comprises the following steps: coating functionalized nanoparticles by using a micro-fluidic technology and a complex coagulation method to prepare microcapsules, coating the surface of the microcapsules by using dopamine hydrochloride auto-polymerization reaction to form coating microcapsules, and finally blending with the functionalized nanoparticles, thereby dividing the antigen into an inner part and an outer part. After entering a body, the nano-microparticle carrier double burst release vaccine is subjected to antigen double burst release with time lag intervals in different time periods; the prepared vaccine can release antigens firstly, then effectively collect and activate antigen presenting cells, the antigen presenting cells uptake the antigen presenting cells to cause immune response, and the generation of specific antibodies can be effectively induced by two times of antigen release through the time-delay coating, so that a traditional natural immune procedure is simulated.

This invention discloses a multifunctional gradient-coated proppant based on functionalized nanoparticles and its preparation method. The multifunctional gradient-coated proppant includes a proppant core and a composite coating with a gradient structure covering the surface of the proppant core. The composite coating includes an inner layer connected to the proppant core and an outer layer composed of functionalized nanoparticles connected to the inner layer. The inner layer is composed of a cross-linked resin, and the functionalized nanoparticles are selected from one or more of amino-modified nanoparticles, guanidine-modified nanoparticles, and quaternary ammonium salt-modified nanoparticles. This invention utilizes the dual mechanism of "electrostatic adsorption + hydrogen bond anchoring" or the synergistic effect of "electrostatic + hydrophobic" of the outer functionalized nanoparticles to significantly improve the proppant's resistance to fragmentation while achieving strong capture of formation particles and effective inhibition of gas hydrate formation, making it suitable for oil and gas extraction under complex geological conditions.

The system disclosed comprises an apparatus and a method for the detection and quantification of targeted molecules in vivo. The apparatus comprises an implantable biosensor and an AC magnetic detection device. The implantable biosensor includes functionalized nanoparticles functionalized with one or more moieties that bind to a molecular target of interest. The nanoparticles are retained in a biocompatible container which allows the molecular target of interest to enter the biosensor, for example through a semipermeable port. The biosensor can be implanted minimally-invasively into humans or animals. Upon exposure of the nanoparticles to the molecular target, a change in Neel relaxation time can be externally detected and correlated to the target analytes concentration. The change in relaxation time is detected through magnetic AC spectrometric measurements at a frequency specifically tuned to the nanoparticle type of interest Additionally, a method is provided for quantifying one or several biosensors within one specimen.

Functionalized nanoparticles for inhibiting or preventing pathogen infections (e.g., viral or bacterial infections, such as coronavirus infections) are described. The nanoparticles comprise a biodegradable polymer core and a lipid coating layer that is functionalized with a pathogen-binding receptor (e.g., an angiotensin-converting enzyme 2 (ACE2) receptor protein) and / or a pathogen-binding antibody or an antigen-binding fragment thereof (e.g., a virus-binding antibody or an antigen-binding fragment thereof). The nanoparticles are further functionalized by a phagocyte-specific ligand, e.g., a phosphatidylserine-containing lipid included in the lipid coating layer, to promote clearance of nanoparticle-bound pathogen. Methods of using the nanoparticles to treat or prevent pathogen infections (e.g., coronavirus infections) are also described.

A method of stimulating a subterranean formation includes preparing an aqueous dispersion including one or more cellulosic nanoparticles. The cellulosic nanoparticles have respective surfaces functionalized with one or more hydrophilic polymers or ligands, one or more hydrophobic polymers or ligands, or a combination thereof. The method also includes pumping the aqueous dispersion into the subterranean formation.

The present invention discloses a functionalized ordered mesoporous organosilicon microsphere with a Yolk-Shell structure and a preparation method thereof. The preparation steps include: (1) using functionalized nanoparticles as cores, utilizing a sol-gel chemical synthesis method, and wrapping a layer of amorphous silica on the surface of the functionalized nanoparticles through a hydrolysis and condensation process of a silicon source precursor at room temperature to obtain functionalized core-shell particles; (2) using the functionalized core-shell particles as seeds, dispersing them in a mixed solution containing deionized water, ethanol, ammonia water and a surfactant, adding organosilane to react, and obtaining functionalized ordered mesoporous organosilicon microspheres with a Yolk-Shell structure. Compared with the "post-etching method" preparation technology, the "quasi-one-step method" of the present invention has mild reaction conditions, simpler and more efficient preparation steps; in addition, by adopting different functionalized cores, Yolk-Shell mesoporous microspheres with different functions can be obtained, which has good universality.

This invention discloses a biodegradable PBAT coating resin, its preparation method, and its applications, belonging to the field of polymer material modification technology. The specific preparation method involves: PBAT-M copolymers are prepared by polycondensation of terephthalic acid, adipic acid, 1,4-butanediol, and 2-methyl-1,3-propanediol under a catalyst; the PBAT-M copolymer, initiator, and maleic anhydride are mixed and melt-extruded to obtain maleic anhydride-grafted modified PBAT-M copolymers; silica nanoparticles are dispersed in an acetic acid solution of chitosan to obtain chitosan surface-functionalized silica nanoparticles; the maleic anhydride-grafted modified PBAT-M copolymer, chitosan surface-functionalized silica nanoparticles, flow modifier, and PBAT are mixed and melt-extruded to obtain a biodegradable PBAT coating resin. This invention improves melt flowability by introducing a side-methyl-containing comonomer, enhances interfacial adhesion to paper substrates through maleic anhydride grafting, and imparts antibacterial and reinforcing properties to the material through chitosan surface-functionalized nanoparticles.

The application discloses an ultrastable antibioadhesion coating and a preparation method and application thereof, and belongs to the technical field of functional materials. The coating provided by the application comprises an A component and a B component; the A component comprises nanoparticles, carboxyl silicone oil, a silane coupling agent and a solvent; the B component comprises a base material and a solvent; the nanoparticles comprise at least one of silicon nanoparticles, iron nanoparticles or zinc nanoparticles; and the base material comprises an epoxy resin. The carboxyl silicone oil and the functionalized nanoparticles are combined through cooperation of the A component and the B component and are embedded in the base material, so that the prepared coating can be used for preparing the ultrastable antibioadhesion coating, the stability and durability of the coating are good, and the coating can effectively reduce adhesion of blood components, proteins, bacteria and cells and the like, and the coating and the prepared coating have good application prospects in implantable medical devices.