32 results about "Functionalized nanoparticles" patented technology

This disclosure relates to polyethylene glycol (PEG) -functionalized nanoparticles comprising a functional agent, and preparation methods, properties and applications thereof. The nanoparticle represented by PEG-L-G / P, comprising a type of hydrophilic PEG, a hydrophobic functional agent G, which are covalently linked by L: a linker or a chemical bond, and a type of hydrophobic polymer P. The G and P form the hydrophobic core, while the PEG constitutes the hydrophilic outer layer of the nanoparticle in an aqueous medium. The functional agent comprises one or more functional compounds including a therapeutic drug, an imaging diagnostic agent, a photoelectric responsive diagnostic agent, an immune-stimulating agent, or a combination thereof. The nanoparticles comprising such functional agent can offer various applications in multiple biomedical fields.

The invention provides a nitrogen-containing boric acid ester-nano hybrid composite anti-wear additive as well as a preparation method and application thereof, and belongs to the technical field of lubricating oil additives. The nitrogen-containing boric acid ester, the functionalized nanoparticles, the ionic liquid, the auxiliary anti-wear agent and the dispersion stabilizer are subjected to nano-scale hybrid compounding, and the nitrogen-containing boric acid ester, the functionalized nanoparticles, the ionic liquid, the auxiliary anti-wear agent and the dispersion stabilizer have a synergistic effect on four aspects of physical bearing, chemical adsorption, interface modification and extreme pressure enhancement; a multi-synergistic lubrication and protection system of an adsorption film, a physical isolation layer, an extreme pressure reaction layer and rolling lubrication microspheres is constructed, efficient wear resistance, friction reduction, bearing and stability improvement are jointly achieved, and the lubricating oil is suitable for insoluble base oil.

The invention discloses a targeted anti-aging microneedle drug delivery system for chronic wound repair as well as a preparation method and application of the targeted anti-aging microneedle drug delivery system. The system is composed of functionalized nanoparticles and a microneedle platform: a nano drug-loading unit which takes a polydopamine nanosphere as a carrier, entraps an anti-aging drug Bem, and modifies the surface of the nano drug-loading unit with a targeting peptide E7; according to the micro-needle delivery unit, hyaluronic acid-nitrogen carboxymethyl chitosan hydrogel is used as a matrix, a nano drug-loading unit and silver ions (Ag) are loaded, a micro-needle array is formed, and minimally invasive transdermal drug delivery is achieved. According to the invention, multiple mechanisms of anti-aging (APCs aging inhibition), antioxidation (ROS removal), antibiosis (Agaction) and immunoregulation (macrophage M2 type polarization promotion) are synergistically exerted, and the bottleneck problems of single intervention target, low drug availability and difficulty in regulating and controlling pathological microenvironment of chronic wounds (such as diabetic foot ulcer) in the traditional therapy are effectively solved.

This invention relates to the field of holographic polymer-dispersed liquid crystal materials technology, providing liquid crystal functionalized nanoparticles, their preparation method, and materials. The liquid crystal functionalized nanoparticles include a nanoparticle core, a surface-modified layer bonded to the nanoparticle core, and a liquid crystal functionalized layer bonded to the surface-modified layer. Advantages: Liquid crystal transformation is achieved by chemically bonding small-molecule liquid crystal building blocks to the nanoparticles. By limiting the types of liquid crystal building blocks, the compatibility between the nanoparticles and the HPDLC system is improved, effectively solving the aggregation problem of traditional nanoparticle-doped HPDLC. Furthermore, this invention utilizes the inductive effect of the liquid crystal building blocks bonded to the nanoparticles and the high diffusion coefficient of the small-molecule liquid crystal building blocks, combined with the chemical potential gradient driving the holographic photopolymerization process and the excellent compatibility between the nanoparticles and the liquid crystal, to achieve directional enrichment of nanoparticles into liquid crystal microregions, further improving phase separation regularity.

In a method of preparing a flow cell, a slot die coater is used to introduce a nanoparticle suspension at a continuous flow rate to a substrate surface including depressions separated by interstitial regions, which generates a layer of the nanoparticle suspension at a stable concentration across the substrate surface. During the introduction of the nanoparticle suspension, at least some functionalized nanoparticles within the layer respectively enter at least some of the depressions. An excess amount of the layer is removed from the interstitial regions.

The invention belongs to the technical field of oil-based super lubrication, and particularly relates to a construction method of super-lubrication low-viscosity polar polyether modified silicone oil. The preparation method comprises the following steps: reacting allyl polyether with hydrogen-containing silicone oil according to a mass ratio of (70-80): 1 under the catalytic condition of chloroplatinic acid to obtain low-viscosity polar polyether modified silicone oil, and mixing 0.5 wt.%-1.5 wt.% of a polar additive, 0.1 wt.%-0.5 wt.% of surface functionalized nanoparticles and 97.5 wt.%-99.4 wt.% of the low-viscosity polar polyether modified silicone oil according to mass percent to obtain the compound lubricating oil. Performing ultrasonic treatment on the composite lubricating oil, and standing to obtain the super-lubricating low-viscosity polar polyether modified silicone oil. The polar additive molecules and the small-size and easy-to-disperse functional nanoparticles are compounded at the same time, so that the interaction between a lubricating film and a friction surface is remarkably enhanced in a cross-scale manner, and a friction pair motion interface is promoted to form a friction composite film with high bearing and low shearing characteristics; and stable ultralow friction and abrasion under the working conditions of wide rotating speed and wide load are achieved, and theoretical and technical supports are provided for engineering application of the oil-based super-lubrication technology.

A method of recovering a product-of-interest from a plant or algal cell and a kit relating to the same are provided. The method of recovering a product-of-interest from a plant or algal cell includes (a) culturing a plant or algal cell that produces a product-of-interest in a culture medium; (b) adding functionalized nanoparticles to the culture medium, whereby the nanoparticles enter the plant or algal cell, bind the product-of-interest, and are extruded into the culture medium; (c) recovering the extruded nanoparticles from the culture medium; and (d) separating the product-of-interest from the extruded nanoparticles. The kit includes a plant or algal cell that produces a product-of-interest when in culture and a functionalized nanoparticle. Also provided is a method of separating plant or algal cells.

The present invention is in the field of pre-functionalized nanoparticles (NPs). It more particularly relates to the use of NPs pre-functionalized with self-assembled monolayers (SAMs), and also to the use of NPs functionalized with biomolecules, such that the NPs are stable in solution. These NPs can be used in a variety of applications, in particular as diagnostic tools, depletion tools of target molecules in solution, and therapeutic tools.

The application belongs to the technical field of water treatment, and particularly relates to a reverse osmosis membrane scale inhibitor and application thereof. The reverse osmosis membrane scale inhibitor provided by the application comprises a macromolecular scale inhibitor, modified nanoparticles, tartaric acid, ethylenediaminetetraacetic acid and water. The application adopts the macromolecular scale inhibitor and the modified nanoparticles to be compounded as main components of the reverse osmosis membrane scale inhibitor, and adopts the tartaric acid and the ethylenediaminetetraacetic acid as auxiliary scale inhibition components, so that the scale inhibition effect of the reverse osmosis membrane scale inhibitor is effectively improved. The macromolecular scale inhibitor is synthesized by taking acrylic acid, allyl benzene sulfonic acid and N-hydroxymethyl acrylamide as monomers, so that the scale inhibition performance is improved, and the scale inhibitor itself is prevented from being precipitated. The 2-acrylamide-2-methylpropane sulfonic acid is grafted on the amino-functionalized nanoparticles, so that the normal growth of a crystal is destroyed through electrostatic repulsion and steric hindrance effect, and the scale inhibition performance of the reverse osmosis membrane scale inhibitor is improved.

The invention relates to a preparation method of a nano-composite microbial agent for efficiently removing kitchen waste grease. Pseudomonas, alcaligenes, bacillus and candida which have high grease degradation capacity are screened out from grease polluted water and kitchen waste compost, and the proportion of the pseudomonas, the alcaligenes, the bacillus and the candida is optimized to form the efficient composite flora. The preparation method comprises the following steps: synthesis of the magnetic Fe3O4 nanoparticles, surface functionalization treatment and synthesis and immobilization of the complex microbial inoculant. The stable and efficient nano-composite microbial agent is prepared by combining the functionalized nano-particles with the composite flora. Experimental verification shows that the complex microbial inoculant shows excellent stability and degradation performance in the application of removing kitchen waste grease, and can be repeatedly used through a magnetic separation technology. Compared with a traditional method, the method has the advantages that the grease removal efficiency is improved, the treatment cost is reduced, and the method has a wide application prospect.

The invention relates to the technical field of medicine, in particular to an antigen double burst release self-boosting immune vaccine and application thereof.The antigen double burst release self-boosting immune vaccine is characterized in that antigens are loaded inside and outside complex coacervation microcapsules in the vaccine, nanoparticles are prepared through a nanoprecipitation method, the nanoparticles and cell membranes jointly entrap the antigens to form functional nanoparticles, and the functional nanoparticles are used as functional nanoparticles; the preparation method comprises the following steps: coating functionalized nanoparticles by using a micro-fluidic technology and a complex coagulation method to prepare microcapsules, coating the surface of the microcapsules by using dopamine hydrochloride auto-polymerization reaction to form coating microcapsules, and finally blending with the functionalized nanoparticles, thereby dividing the antigen into an inner part and an outer part. After entering a body, the nano-microparticle carrier double burst release vaccine is subjected to antigen double burst release with time lag intervals in different time periods; the prepared vaccine can release antigens firstly, then effectively collect and activate antigen presenting cells, the antigen presenting cells uptake the antigen presenting cells to cause immune response, and the generation of specific antibodies can be effectively induced by two times of antigen release through the time-delay coating, so that a traditional natural immune procedure is simulated.

This invention discloses a multifunctional gradient-coated proppant based on functionalized nanoparticles and its preparation method. The multifunctional gradient-coated proppant includes a proppant core and a composite coating with a gradient structure covering the surface of the proppant core. The composite coating includes an inner layer connected to the proppant core and an outer layer composed of functionalized nanoparticles connected to the inner layer. The inner layer is composed of a cross-linked resin, and the functionalized nanoparticles are selected from one or more of amino-modified nanoparticles, guanidine-modified nanoparticles, and quaternary ammonium salt-modified nanoparticles. This invention utilizes the dual mechanism of "electrostatic adsorption + hydrogen bond anchoring" or the synergistic effect of "electrostatic + hydrophobic" of the outer functionalized nanoparticles to significantly improve the proppant's resistance to fragmentation while achieving strong capture of formation particles and effective inhibition of gas hydrate formation, making it suitable for oil and gas extraction under complex geological conditions.

The system disclosed comprises an apparatus and a method for the detection and quantification of targeted molecules in vivo. The apparatus comprises an implantable biosensor and an AC magnetic detection device. The implantable biosensor includes functionalized nanoparticles functionalized with one or more moieties that bind to a molecular target of interest. The nanoparticles are retained in a biocompatible container which allows the molecular target of interest to enter the biosensor, for example through a semipermeable port. The biosensor can be implanted minimally-invasively into humans or animals. Upon exposure of the nanoparticles to the molecular target, a change in Neel relaxation time can be externally detected and correlated to the target analytes concentration. The change in relaxation time is detected through magnetic AC spectrometric measurements at a frequency specifically tuned to the nanoparticle type of interest Additionally, a method is provided for quantifying one or several biosensors within one specimen.

A method of stimulating a subterranean formation includes preparing an aqueous dispersion including one or more cellulosic nanoparticles. The cellulosic nanoparticles have respective surfaces functionalized with one or more hydrophilic polymers or ligands, one or more hydrophobic polymers or ligands, or a combination thereof. The method also includes pumping the aqueous dispersion into the subterranean formation.

This invention discloses a biodegradable PBAT coating resin, its preparation method, and its applications, belonging to the field of polymer material modification technology. The specific preparation method involves: PBAT-M copolymers are prepared by polycondensation of terephthalic acid, adipic acid, 1,4-butanediol, and 2-methyl-1,3-propanediol under a catalyst; the PBAT-M copolymer, initiator, and maleic anhydride are mixed and melt-extruded to obtain maleic anhydride-grafted modified PBAT-M copolymers; silica nanoparticles are dispersed in an acetic acid solution of chitosan to obtain chitosan surface-functionalized silica nanoparticles; the maleic anhydride-grafted modified PBAT-M copolymer, chitosan surface-functionalized silica nanoparticles, flow modifier, and PBAT are mixed and melt-extruded to obtain a biodegradable PBAT coating resin. This invention improves melt flowability by introducing a side-methyl-containing comonomer, enhances interfacial adhesion to paper substrates through maleic anhydride grafting, and imparts antibacterial and reinforcing properties to the material through chitosan surface-functionalized nanoparticles.

In a method of preparing a flow cell, a slot die coater is used to introduce a nanoparticle suspension at a continuous flow rate to a substrate surface including depressions separated by interstitial regions, which generates a layer of the nanoparticle suspension at a stable concentration across the substrate surface. During the introduction of the nanoparticle suspension, at least some functionalized nanoparticles within the layer respectively enter at least some of the depressions. An excess amount of the layer is removed from the interstitial regions.

Compositions for photothermally triggered delivery of a neurally active compound and methods of modulating neural activity of preparations containing neurally active cells using the disclosed compositions are disclosed herein. The disclosed compositions include a plurality of functionalized nanoparticles that include a nanoparticle core, a mesoporous coating formed over the nanoparticle core defining a plurality of nanopores, and a mixture of a neurally active compound and a phase change material within the plurality of nanopores. The neurally active compound is selectively released from the composition when the functionalized nanoparticles are heated to a temperature above a melting point of the phase change material. Methods of modulating neural activity include augmenting biohybrid chemical sensors through nano-neuromodulation, and modulation of neural activity of brain organoid preparations.

The present invention belongs to the area of materials engineering. The present invention relates to a anti-spatter welding coating that has an innovative technology in protecting against weld spatter originated during welding processes. The formed protective film has, in its composition, functionalized nanoparticles with sizes ranging from 10 to 100 nm, dispersed in polymeric matrices giving rise to composites that provide the film with unique properties, which effectively prevent the adhesion of spatter. The coating of the present invention consists of the application and drying of a liquid paint with low solids content, from 2.5 to 6.0%, composed of a co-solvent system, in which the majority, about 50 to 70%, by mass, and deionized water and 20 to 40% are alcohol-type solvents or equivalents. The coating does not require curing processes, consumes little energy, has a reduced cost and is extremely environmentally friendly (eco-friendly) and for the health of the worker, not containing fluorinated materials. The paint disclosed herein has excellent adhesion on metal surfaces, withstands high temperatures of up to 600°C, has adjustable viscosity (400 to 1200 cP), good lubricity and results in a film that, after drying, has a thickness that can reach values between 5 µm and 30 µm and an adjustable torque of 1 N / m up to 10 N / m. This solution designed for the automotive market also extends to other types of market that need to eliminate the loss or rework of metal parts contaminated with weld spatter.

Functionalized nanoparticle composition comprising 5-fluorouracil for enhanced anticancer activity, the composition comprising: a. 5-Fluorouracil at a quantity of 10.00% w / w, configured as an active anticancer agent; b. Poly(lactic acid-co-glycolic acid) at a quantity of 60.00% wt / w, configured to encapsulate the 5-fluorouracil and form a biodegradable nanoparticle matrix; c. Polyethylene glycol (PEG-2000) in an amount of 10.00% (w / w) configured to functionalize the surface of the nanoparticles and improve stability and bioavailability; d. Chitosan at a quantity of 5.00% (wt / wt), configured to effect surface modification and improve cellular uptake and targeting accuracy; e. Polyvinyl alcohol in an amount of 3.00% wt / wt, configured as a stabilizing and emulsifying agent during nanoparticle formation; f. Tween 80 at a concentration of 2.00% w / w, configured to improve dispersion stability and control particle size; and g. Mannitol at a quantity of 10.00% w / w, configured as a cryoprotectant to enhance stability during lyophilization and storage; the composition offering improved drug incorporation efficiency, delayed drug release, improved bioavailability, and enhanced anticancer activity compared to non-functionalized formulations of 5-fluorouracil.

The disclosed subject matter provides methods and apparatus for detecting a target analyte in a sample. The method includes providing nanoparticles functionalized with one or more recognition molecules configured to bind specifically to the target analyte; exposing the sample containing the target analyte and the functionalized nanoparticles to an acoustic field comprising a surface standing acoustic wave (SSAW); inducing aggregation of the nanoparticles mediated by the target analyte under acoustic stimulation of SSAW; and detecting the aggregation of the nanoparticles as an indication of the presence of the target analyte.

The invention relates to an antiviral drug-loaded functional nanoparticle, and collagen-based hydrogel eye drops based on in-situ catalytic oxygen production as well as a preparation method and application of the collagen-based hydrogel eye drops. The invention provides application of snowflake-shaped manganese dioxide nanoparticles SM in preparation of a carrier or an auxiliary material of a collagen-based hydrogel ophthalmic preparation. The invention also provides a functionalized nanoparticle loaded with an antiviral drug, which takes the snowflake-shaped manganese dioxide nanoparticle SM as a carrier to load the antiviral drug. The invention further provides collagen-based hydrogel eye drops based on in-situ catalytic oxygen production. Aiming at viral keratitis, an original platform technology integrating intelligent drug delivery, in-situ oxygenation treatment and immune microenvironment regulation is used for the first time, and the inherent defects that a currently reported method cannot treat virus infection, depends on external equipment and cannot regulate and control a host pathological microenvironment are overcome; the invention provides a novel HSK treatment strategy which is more intelligent, integrated, safe and patient-friendly, and has remarkable progress and outstanding substantive features.

The invention discloses biodegradable PBAT (poly (butylene adipate-co-terephthalate)) spraying film resin, a preparation method and application, and relates to the technical field of high polymer material modification, and the specific preparation method comprises the following steps: carrying out condensation polymerization on terephthalic acid, adipic acid, 1, 4-butanediol and 2-methyl-1, 3-propylene glycol under the action of a catalyst to prepare a PBAT-M copolymer; uniformly mixing the PBAT-M copolymer, an initiator and maleic anhydride, and performing melt extrusion to obtain a maleic anhydride grafted modified PBAT-M copolymer; the preparation method comprises the following steps: dispersing silicon dioxide nanoparticles in an acetic acid solution of chitosan to obtain chitosan surface functionalized silicon dioxide nanoparticles; and uniformly mixing the maleic anhydride grafted modified PBAT-M copolymer, the chitosan surface functionalized silicon dioxide nanoparticles, a flow modifier and PBAT, and carrying out melt extrusion to prepare the biodegradable PBAT spraying film resin. The melt flowability is improved by introducing a comonomer containing side methyl, the interface adhesion with a paper base is improved through maleic anhydride grafting, and the material is endowed with antibacterial and reinforcing properties through chitosan surface functionalized nanoparticles.

The invention discloses a nanoparticle cross-linked hydrogel and an application thereof, the nanoparticle cross-linked hydrogel is prepared from end group functionalized nanoparticles and a side chain functionalized modified hydrophilic polymer material, because a thiol group and an unsaturated double bond group can be connected through a Michael addition reaction, the cross-linked hydrogel has the advantages that the cross-linked hydrogel has good biocompatibility; therefore, a thiol group and an unsaturated double-bond group are selected to form a connecting bond of the nanoparticles and a hydrophilic high-molecular material, so that hydrogel forming is realized. According to the hydrogel delivery system taking the nanoparticles as the cross-linking agent, loading and delivery of various drugs are realized through a dual loading strategy of the nanoparticles and the hydrogel.

The invention relates to the field of water treatment, and discloses a functionalized nanoparticle as well as a preparation method and application thereof. The nanoparticle has a core-shell structure, the shell is an aromatic amine polymer, and the core is a magnetic nanoparticle; wherein on the basis of the total weight of the functionalized nanoparticles, the mass percentage of the element N is 2-20 wt%. The functionalized magnetic nanoparticles take nanoparticles as cores and aromatic amine polymers as shells, so that the surfaces of the functionalized nanoparticles are enriched with N elements, which indicates that the surfaces of the nanoparticles contain a large number of N-containing functional groups, so that the functionalized nanoparticles have a large specific surface area, and the adsorption capacity of the nanoparticles to heavy metal ions is improved; heavy metal ions in water can be effectively adsorbed.

Provided is a test device for performing a lateral flow test for testing a presence of a target analyte in a sample fluid. The test device comprises a test substrate, wherein the test substrate includes a plurality of functionalized nanoparticles and one or more nanoscale objects. Each nanoscale object is or comprises a DNA origami.

The invention relates to the technical field of magnetic microcapsules, in particular to preparation of a magnetosome-based magnetic microcapsule and application of the magnetosome-based magnetic microcapsule in preparation of magnetic beads. The method comprises the following steps: extracting magnetosomes of which the surfaces display specific membrane proteins from magnetotactic bacteria modified by genetic engineering, purifying, carrying out surface chemical modification by adopting bifunctional molecules, and introducing active amino groups or carboxyl groups; carrying out biological orthogonal reaction or electrostatic self-assembly on the modified magnetosome and the functionalized nanoparticles under mild conditions to form a primary complex; the preparation method comprises the following steps: adding a degradable cross-linking agent containing dynamic disulfide bonds and a biocompatible polymer stabilizer into CMC (Carboxymethyl Cellulose), and inducing to form a composite magnetosome cluster with the size of 50-200nm and a core-shell structure through an ultrasonic-assisted directional assembly and solvent evaporation combined technology. The magnetic material has excellent biocompatibility, high magnetization intensity and magnetic thermal efficiency, and solves the problems of toxicity, aggregation and performance bottleneck of chemically synthesized particles.

The invention discloses a multi-component high-strength anti-icing material as well as a preparation method and application thereof, and belongs to the technical field of anti-icing materials. The method comprises the following steps: defibering and dispersing fibers, and carrying out wet molding to obtain a preformed sheet; impregnating the preformed sheet in a binder resin solution, and performing hot-pressing curing to obtain a fiber skeleton; and dipping the fiber skeleton in the polymer precursor solution doped with the functionalized nanoparticles, and curing to obtain the multi-component high-strength anti-icing material. The rigid micron porous fiber skeleton provides mechanical strength; the anti-icing durability of the anti-icing material is enhanced by a multi-scale multi-component synergistic mechanism among hydrophobic oleophylic functional groups, nanoparticles and polymer molecular chain segments; the multi-scale modulus difference characteristic among the nanoparticles, the fibers, the polymer and ice induces the instability of an ice-solid interface, so that the material is endowed with excellent anti-icing performance. The coating has the advantages of low ice adhesion, excellent mechanical strength and long-term durability, and is suitable for ice coating protection on the surfaces of key parts such as aircraft wings, wind driven generator blades and marine equipment.

This disclosure relates to polyethylene glycol (PEG)-functionalized nanoparticles comprising a functional agent, and preparation methods, properties and applications thereof. The nanoparticle represented by PEG-L-G / P, comprising a type of hydrophilic PEG, a hydrophobic functional agent G, which are covalently linked by L: a linker or a chemical bond, and a type of hydrophobic polymer P. The G and P form the hydrophobic core, while the PEG constitutes the hydrophilic outer layer of the nanoparticle in an aqueous medium. The functional agent comprises one or more functional compounds including a therapeutic drug, an imaging diagnostic agent, a photoelectric responsive diagnostic agent, an immune-stimulating agent, or a combination thereof. The nanoparticles comprising such functional agent can offer various applications in multiple biomedical fields.

The present application relates to the field of droplet transport speed regulation, and discloses a method for regulating the droplet transport speed in a microchannel based on nanoparticle surfactant, which specifically comprises the reaction of carboxyl-functionalized nanoparticles in an aqueous phase and amino-terminated polydimethylsiloxane in an oil phase at an oil-water interface to generate nanoparticle surfactant. The nanoparticle surfactant can significantly reduce the oil-water interfacial tension, and the interface adsorbed by the nanoparticle also exhibits special mechanical properties such as viscoelasticity and bending resistance, so as to regulate the droplet transport speed in the microchannel.

The invention relates to the technical field of environmental engineering, and discloses a preparation method and application of a magnetic geosmin molecularly imprinted polymer, and the preparation method comprises the following steps: (1) reacting surface-functionalized nanoparticles with a silane coupling agent KH-570 in a toluene solution to obtain modification; (2) dissolving a virtual template molecule cis-decahydro-1-naphthol and a functional monomer methacrylic acid in acetonitrile, carrying out a prepolymerization reaction, then adding the modified cross-linking agent ethylene dimethacrylate obtained in the step (1) and an initiator azodiisobutyronitrile, and carrying out a polymerization reaction at 50-60 DEG C under the protection of nitrogen; and (3) after the reaction is completed, separating a product through an external magnetic field, washing and drying to obtain a crude product. The adsorption capacity of the material to geosmin is far higher than that of a non-imprinted material (the adsorption capacity reaches 5.58 mg / g in an embodiment 3), the material has excellent complex matrix interference resistance, and a target object can be accurately captured from coexisting substances such as soluble organic matter and humus.