The invention relates to a processing method of lonicera edulis, in particular to a processing method which adopts microwave vacuum technology for the extrusion of lonicera edulis chip, belonging to the field of food processing. The technical process is as follows: cleaning fresh lonicera edulis, cleaning, protecting color, pulping, adding starch, mixing, stirring, heating, pasting, preparing dough, cooling, kneading, slicking, predrying by hot wind, vacuum pulping by microwave, and obtaining a finished product. The condition for vacuum pulping by microwave is as follows: after predrying, initial moisture content is 25-45%, vacuum degree is 70-90 kPa, unit mass microwave power is 10-30 W/g, and microwave output power is 2-5 kW. The lonicera edulis which is puffed by microwave in vacuum has high comprehensive quality, is favourable for storing nutrition constituents and greatly saves energy consumption.