245 results about "Biodegradable polymer" patented technology

The invention discloses a preparation method of a composite slow-release carbon source, which comprises the following steps: preparing an inner core: uniformly dry-mixing lignin powder and a quick-acting carbon source, and adding a first binder to prepare inner core particles; middle layer wrapping: alternately spraying a second binder and middle layer coating powder until the middle layer is completely wrapped to obtain double-layer particles; outer layer wrapping: alternately spraying a third binder and outer layer coating powder until the outer layer is completely wrapped to obtain three layers of particles; and spraying a biodegradable polymer solution on the surfaces of the three layers of particles to form a coating film. Through the three-layer structural design of the quick start layer, the stable maintenance layer and the long-acting guarantee layer, accurate matching of carbon source release and microbial metabolism requirements is realized. The outer-layer quick-acting carbon source quickly starts microbial activity, the middle layer provides stable and continuous carbon source supply, and the inner core ensures the tail-section treatment effect. The sequential release mechanism effectively avoids burst release waste of the carbon source, so that the utilization rate of the carbon source is greatly improved.

A biodegradable composition is disclosed. The biodegradable composition includes (i) a biodegradable polymer and (ii) a cellulose ester. Films that include or are formed from the biodegradable composition, as well as articles that include a substrate and a layer of the biodegradable composition on a surface thereof, are also described.

The invention discloses an anisotropic electrostatic spinning patch with ultrasonic response and a preparation method thereof, a fiber membrane with a controllable anisotropic structure is constructed by a biodegradable polymer, antibacterial nanoparticles and a photoinitiator system through a step-by-step directional electrostatic spinning process, so that the mechanical matching property of the fiber membrane is improved; cell growth can be directionally guided and tissue regeneration can be accelerated by combining the piezoelectric material characteristics of the introduced biodegradable polymer with piezoelectric characteristics and electric field stimulation induced by the fiber topological structure; meanwhile, a zwitterionic coating is generated on the surface of the fiber membrane in situ by utilizing a single-sided photocuring technology, and an anti-adhesion function is realized on the single side of the fiber membrane. Furthermore, the soft tissue repair patch which has multiple functions of adjustable mechanical property, infection resistance, adhesion resistance and the like and has better structural mechanical suitability, function integration and tissue regeneration guiding capability is prepared by adopting the anisotropic electrostatic spinning patch with ultrasonic response.

The invention relates to the technical field of biodegradable high polymer materials, in particular to a tear-resistant high-barrier biodegradable mulching film and a preparation method thereof, and the tear-resistant high-barrier biodegradable mulching film is prepared from the following raw materials in parts by weight: 60-90 parts of poly (butylene adipate-co-terephthalate); 10 to 40 parts of poly (propylene carbonate); 0.5-5 parts of a plasticizer; 0.05 to 0.3 part of a cross-linking agent; 0.1 to 10 parts of talcum powder; 0.1 to 2 parts of a lubricant; 0.1-1 part of an anti-blocking agent; 0.1 to 1 part of an antioxidant; 0.1 to 1 part of an anti-ultraviolet agent; 0.1-1 part of a light stabilizer; 0.1 to 1 part of an anti-hydrolysis agent; 0.1-1 part of a nucleating agent; the plasticizer is poly (1, 2-propylene glycol adipate); and the cross-linking agent is 1, 4-bis (tert-butylperoxy) diisopropyl benzene. The film has good mechanical properties and water vapor transmission amount, can be completely biodegraded, and has good aging resistance.

The invention provides a degradable and stretchable wireless sensor with a multilayer circuit and a preparation method of the degradable and stretchable wireless sensor. The wireless sensor comprises an integrated folding structure and a packaging layer, the integrated folding structure comprises a plurality of layers of snakelike wire structures and a plurality of electrode plates; the snakelike wire structure provides inductance, and the electrode plate provides capacitance; the snakelike wire structure is formed by a planar and multi-cycle snakelike wire structure formed by a biodegradable metal and biodegradable polymer composite layer through multiple times of 180-degree twisting and folding, and patterns of the snakelike wire structure are overlapped after folding so as to realize effective series connection of the inductance coils; the electrode plates are bonded with each other through a biodegradable dielectric layer; the snakelike wire structure adopts a neutral axis separation design at the arc section, namely, the wire width is divided into multiple strands. Reliable series connection of multiple layers of coils can be achieved, inductance is effectively increased, high-frequency resistance is reduced, and therefore wireless transmission performance is improved, and meanwhile the requirements for flexibility, stretchability and biodegradability are completely met.

The invention relates to a QS-21 loaded nano adjuvant as well as a preparation method and application thereof. According to the nano adjuvant, the biodegradable polymer, cholesterol and cationic lipid entrapped QS-21 are utilized to form solid lipid particles in an O / W mode, the solid lipid particles have good dispersity, the surfaces of the solid lipid particles are positively charged, and the solid lipid particles can adsorb negatively charged antigen protein to prepare a nano adjuvant vaccine. The cholesterol in the nano adjuvant vaccine can be combined with the QS-21, so that entrapment of the QS-21 can be better realized, the safety and the stability of the nano adjuvant vaccine are improved, and the nano adjuvant vaccine has a wide application prospect in prevention of virus infection.

The application discloses an oral nano-vaccine and a preparation method and application thereof, and relates to the technical field of immunology, and specifically discloses an oral nano-vaccine which comprises a nano-particle wrapped by a biomimetic bacterial membrane vesicle and an outer layer; the nano-particle comprises an antigen and a biodegradable polymer material; the biomimetic bacterial membrane vesicle comprises an ionizable flagellar lipoprotein, an immune adjuvant, a phospholipid, a sterol lipid and a polyethylene glycol lipid; and the outer layer is a pH-responsive polymer. The oral nano-vaccine provided by the application combines the immune activation advantages of natural bacterial membrane vesicles and the precise regulation characteristics of synthetic materials, significantly improves the transmembrane penetration capacity of the antigen in the intestinal epithelium and the overall activation effect of the mucosal immune system. The oral nano-vaccine provided by the application can protect the antigen and the immune adjuvant from degradation and realize precise release in the intestinal microenvironment; and the oral nano-vaccine significantly improves the bioavailability and safety of an oral tumor vaccine, and lays a key technical foundation for clinical transformation and large-scale production of the oral tumor vaccine.

The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.

The present application belongs to the technical field of inorganic fixed luminescent materials and medical polymer elastic stents, and relates to an elastic stent composed of near-infrared inorganic stress luminescent material and organic polymer and a preparation method. The composite elastic stent provided by the present application is manufactured by using 3D printing technology, adopts biodegradable polymer material as a printing base material, and adopts inorganic near-infrared stress luminescent material as a reinforcing phase material and a luminescent base, so that the hollow, cylindrical and net-shaped polymer composite elastic stent required is printed on a cylindrical surface base, and the composite elastic stent can be applied to real-time monitoring of the internal microenvironment of a blood vessel after an operation.

To provide an aerosol composition that enables a biodegradable polymer thin film to be readily formed on a target material with high productivity.SOLUTION: An aerosol composition contains a propellant containing dimethyl ether, and a biodegradable polymer that is soluble in the dimethyl ether.SELECTED DRAWING: None

Use of a spreading granulate as infill granulate for grass and artificial turf pitches, wherein the infill granulate comprises a polymer matrix with a proportion of between 10 wt.% and 100 wt.% of at least one biodegradable polymer and at least one filler from the group of natural fillers embedded in the polymer matrix with the at least one biodegradable polymer, characterized in that the infill granulate comprises at least one filler from the group of crushed fruit kernels with a higher hardness than that of the polymer matrix.

Disclosed is a polymer composition including a polyester copolymer and a biodegradable polymer, wherein the polyester copolymer includes two types of ester bond-forming monomer residues as main structural units, when the two types of ester bond-forming monomers are defined as “monomer A” and “monomer B”, respectively, the polyester copolymer satisfies (1) to (3) below, the biodegradable polymer has a melting point of 100° C. or higher, and the biodegradable polymer is included in an amount of 0.1% by weight or more and less than 30% by weight in 100% by weight of the total of the polyester copolymer and the biodegradable polymer. The present invention provides a polymer composition having low Young's modulus and high tensile strength. (1) An R value represented by the following formula is 0.45 or more and 0.99 or less. R=[AB] / (2[A][B])×100, where [A]: molar fraction (%) of monomer A residues in the polyester copolymer, [B]: molar fraction (%) of monomer B residues in the polyester copolymer, and [AB]: molar fraction (%) of a structure in which monomer A residues and monomer B residues are adjacent to each other (A-B and B-A) in the polyester copolymer. (2) A crystallization rate of monomer A residues and a crystallization rate of monomer B residues are less than 14%. (3) A melting point is lower than 100° C. or a clear melting point does not exist.

The invention relates to a biodegradable composite material comprising a biodegradable polymer matrix and Padauk wood particles dispersed in said polymer matrix.

This invention relates to a high-strength, high-toughness polylactic acid (PLA) composite material and its preparation method, belonging to the field of biodegradable polymer materials technology. The PLA composite material formulation is as follows: by weight, 70-80 parts PLA, 5-10 parts modified cellulose nanocrystals, 3-5 parts modified montmorillonite, 1-2 parts plasticizer, and 0.5-1.5 parts antioxidant. The preparation method of the modified cellulose nanocrystals is as follows: cellulose nanocrystals are added to deionized water and ultrasonically treated to obtain dispersion A; a 0.5-1 M tannic acid solution at 60°C is added sequentially to dispersion A; after cooling to room temperature, a 3 M octadecylamine-ethanol solution is added dropwise; the mixture is washed with ethanol and deionized water, and then subjected to stepwise freeze-drying to obtain the modified cellulose nanocrystals. The PLA composite material prepared by the method of this invention exhibits high strength, high toughness, and good high-temperature resistance.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

Provision of drug-containing nanofibers. [Solution] A drug-containing nanofiber containing a biodegradable polymer or biocompatible polymer and a drug.

The application discloses a kind of hierarchical carbon source microspheres for denitrification filter and preparation method thereof, it is related to water treatment field, the preparation method includes the following steps: preparation includes biodegradable polymer, nanofiber and mesoporous template agent precursor solution, and pre-crosslinking is carried out, and resin matrix is obtained;Resin matrix is sprayed into high-temperature inert atmosphere by atomization, and the microsphere precursor a with macroporous structure is formed by solvent evaporation and reaction induced phase separation;Microsphere precursor a is placed in steam environment, and inorganic silicon source precursor is condensed on macroporous structure and in-situ sol-gel reaction occurs, forming a reinforcing layer, to obtain microsphere precursor b;Microsphere precursor b is sequentially subjected to CO2 extraction and post-processing, and the whole microsphere precursor b forms mesoporous and microporous, to obtain hierarchical carbon source microspheres.The application effectively solves the problems of unstable control of carbon source release rate and limited microbial deep colonization by constructing hierarchical pore structure with macroporous, mesoporous and microporous.

The present disclosure relates to methods of preparing biodegradable ocular implants containing edonentan, or a pharmaceutically acceptable salt thereof. The disclosure also relates to biodegradable ocular implants generally comprising a biodegradable polymer and edonentan, or a pharmaceutically acceptable salt thereof.

The invention provides a sequential slow-release hydrogen sulfide nerve repair conduit and a preparation method thereof, and belongs to the technical field of biological materials. The sequential slow-release hydrogen sulfide nerve repair conduit comprises degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel and a pH response hydrogen sulfide donor, wherein the degradable polymer conduit is filled with the degradable temperature-sensitive polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, and the pH response hydrogen sulfide donor is loaded on the hydrogel. In the application, the pH response donor can respond to an acidic microenvironment of degradation of polyethylene glycol monomethyl ether-poly (cysteine-glycolic acid) hydrogel, release hydrogen sulfide and relieve the acidic environment generated by degradation of the hydrogel at the same time, and form a dual supply mechanism with cysteine (endogenous hydrogen sulfide precursor) obtained by degradation of the hydrogel; nerve regeneration and angiogenesis are synergistically promoted, and oxidative stress is regulated; and the hydrogel is accelerated to degrade during excessive oxidative stress, so that hydrogen sulfide is released as required, and the core problems of insufficient blood supply, unbalanced acidic microenvironment and slow nerve regeneration are synchronously solved.

The present disclosure describes a lipid-polymer hybrid nanoparticle and a method of synthesizing such a nanoparticle or a composition containing such a nanoparticle. These nanoparticles are made from a biodegradable polymer-based micellar core surrounded by a lipid-based shell, wherein a majority of the agent is present on the inner periphery of such nanoparticles due to physical adhesion to lipid molecules. Only a small amount of medicament is encapsulated in the micelle core. Thus, the lipid-based shell becomes the primary excipient part of the nanoparticle, and the core containing the biodegradable polymer becomes the secondary excipient part of the nanoparticle.

The present invention concerns a composition for a horticultural pot comprising a solid residue of digestate from methanization and / or a solid residue from composting and a biodegradable polymer chosen from polyhydroxyalkanoates (PHA), its preparation and its use in the manufacture of such a pot.

The present invention relates to a pharmaceutical composition which does not undergo rapid initial burst release of a drug by comprising sustained release microspheres consisting of texipatide or a pharmaceutically acceptable salt thereof, an initial burst release inhibitor, and a biodegradable polymer, has a high drug content with respect to particle size, and has high bioavailability, thus, the composition can minimize patient pain and inflammatory response that may occur when administered to a human body, and thus can be effectively used in the prevention or treatment of diabetes, beta cell dysfunction, hypertension, hyperlipidemia, obesity, and non-alcoholic steatohepatitis.

The present invention relates to a base liquid product, commonly called polyol, with a high hydroxyl index, for forming a biodegradable renewable polymer, which comprises a first base liquid product component mixed and reacted with a second and a third base liquid product component, wherein: the first base liquid product component is selected from at least one of: vegetable oil and / or modified vegetable oil; the second base liquid product component is selected from at least one of: nitrilotriethanol, preferably, and / or monoethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,4 butanediol, nitrilodiethanol and / or nitrilomonoethanol, dimethylpropane, pentaerythritol, glycerin or sorbitol; and the third base liquid product component is selected from at least one of: potassium hydroxide and / or sodium hydroxide.

The present disclosure relates to biodegradable polymers, particularly to a method for converting biodegradable polymers into humus with a low release amount of CO2 and use thereof. A composite material system is formed from the biodegradable polymers and the materials that can slowly release nutrient nitrogen or nutrients nitrogen and phosphorus, in which the mass ratio of carbon to nitrogen in the composite material system is (1-35):1. The materials of the present disclosure can promote the biodegradable polymers to be converted into soil humus or compost humus, rather than to be converted into greenhouse gas CO2, which is to be emitted into the atmosphere.

The invention discloses a polyglutamic acid hemostatic hydrogel and a preparation method thereof. The polyglutamic acid hemostatic hydrogel comprises a phthalic dialdehyde grafted polyglutamic acid derivative and an adipic dihydrazide grafted polyglutamic acid derivative, the o-phthalaldehyde grafted polyglutamic acid derivative has a structure as shown in a formula 1 or a formula 3; the adipic dihydrazide grafted polyglutamic acid derivative has a structure as shown in a formula 2 or a formula 4. The polyglutamic acid hemostatic hydrogel provided by the invention comprises two components, i.e., a phthalic dialdehyde grafted polyglutamic acid derivative and an adipic dihydrazide grafted polyglutamic acid derivative, and polyglutamic acid is a biodegradable high polymer material with good biocompatibility; the hydrogel can realize rapid gelation through rapid reversible cross-linking of o-phthalaldehyde and hydrazino and hydrogen-bond interaction of a main chain of polyglutamic acid, and has excellent mechanical properties and adhesion strength.

The present invention relates to a liquid composite composition comprising biodegradable polymer particles and a water-soluble or water-swellable polymer. The liquid composite composition of the present invention has a particle size distribution (SV) value of 0.4 to 1.0 of biodegradable polymer particles and a complex viscosity (η*) of 5 Pa·s to 200 Pa·s measured under conditions of 25°C and a frequency of 0.1 Hz. According to the present invention, by satisfying a specific range of particle size distribution and complex viscosity, a tissue repair filler composition is provided that has excellent suspension stability even during long-term storage, can be used immediately without a separate rehydration process to significantly reduce the preparation time for the procedure, offers excellent convenience for the procedure with low injection force, and can simultaneously provide an immediate volume improvement effect and a long-term tissue regeneration effect.

The invention discloses a biodegradable anti-aging agent as well as a preparation method and application thereof, and belongs to the field of biodegradable high polymer materials. Dibasic acid, dihydric alcohol and an acid compound containing a hindered phenol structure or an ester derivative of the acid compound are used as raw materials, esterification and condensation polymerization are performed, and then esterification or ester exchange reaction is performed to prepare the macromolecular anti-aging agent, so that high dispersity and migration resistance are realized; the anti-aging agent and the biodegradable resin are mixed and directly subjected to blow molding, film forming, extrusion casting and other melt forming, the hot working process is simplified, and the loss of material mechanics and aging resistance is reduced; the phenolic hydroxyl group can capture free radicals, so that the aging resistance of the biodegradable material is remarkably improved, and the service life of the material is prolonged. The prepared anti-aging biodegradable material can be applied to thin film products, and is particularly suitable for high-performance degradable mulching films and environment-friendly packaging materials.

To provide an implantable device including a tube including a plurality of biodegradable, biocompatible metal wires braided together.SOLUTION: In the expanded state, the tube is coated with a flexible, conformal biodegradable polymer, and when compressed and the compression is released, the flexible, conformal biodegradable polymer-coated tube self-expands to the expanded state.SELECTED DRAWING: Figure 1

The invention provides an ultrasonic response type microsphere preparation entrapped with a protein degradation agent as well as a preparation method and application of the ultrasonic response type microsphere preparation. The microsphere is of a microsphere structure entrapped with a protein degradation agent and formed by a conjugate of a biodegradable polymer and a sound-sensitive agent and the protein degradation agent. According to the invention, the targeted protein degradation agent is entrapped in a biodegradable novel polymer matrix, so that the slow release effect of the medicine is realized, and the long-acting effect is achieved at a specific part in the body. The microsphere combines the respective advantages of an ultrasonic technology and a targeted protein degradation technology, and the two technologies work together, so that the controllability of drug release is remarkably improved, a synergistic effect is achieved, and the treatment effect is improved.