929 results about "Biodegradable polymer" patented technology

A biodegradable polymer composite, a method of making the same and use for same are provided. The biodegradable polymer composite has about 30 to 99.5% by weight of a polymer selected from a group consisting of polybutylene adipate terephthalate (PBAT), polybutylene succinate (PBS), polyhydroxyalkanoates (PHA), and polycaprolactone (PCL) grafted with a compatibilizer selected from a group consisting of maleic anhydride, glycidyl methacrylate, pyromellitic anhydride, acrylic acid, polyacrylic acid, methylene diphenyl diisocyanate, poly(glycidyl methacrylate, copolymer(s) of glycidyl methacrylate; and about 0.5 to 50 % by weight a nano-filler or a micro-filler. The biodegradable polymer composite does not contain polylactic acid. Surfaces of the nano-filler or the micro-filler may be modified using a grafting agent so that the biodegradable polymer composite has enhanced mechanical properties, increased heat resistance, compostablity and / or improved processability. The biodegradable polymer composite may be used to make flexible articles, such as a freezer wrap and a farming sheet.

The invention relates to the technical field of biodegradable materials, and discloses a full-biodegradable bamboo fiber film material and a preparation method thereof, the full-biodegradable bamboo fiber film material comprises the following raw materials by weight: 30-50 parts of modified bamboo fiber, 20-40 parts of a biodegradable polymer, 3-8 parts of a plasticizer, and 1-5 parts of a cross-linking agent. Acrylic acid grafted hydroxyethyl methylacrylate is grafted to epoxy resin containing azobenzene side chains to form a grafting product of a latticed structure, and the grafting product and hydroxyl groups on bamboo fibers form ether bonds to modify the bamboo fibers. The latticed structure can effectively improve the mechanical property of the film, and azobenzene is grafted to the side chain of bisphenol A epoxy resin, so that the epoxy resin has better degradability.

The invention discloses a high-stability endotoxin-free PHA nano-emulsion and a preparation method thereof, and belongs to the technical field of biodegradable high polymer material compositions and processing thereof. The nano-emulsion is characterized in that the endotoxin content is not higher than 0.10 EU / g, the median particle size d50 is 100-200 nm, and the PDI is not higher than 0.15, and the nano-emulsion is stable in long-term storage. The preparation method is a continuous solvent-free process and comprises the steps of melt extrusion, high-pressure thermal emulsification and deep endotoxin removal. By adopting the specific pH-insensitive cationic polymer emulsifier and the crystallization inhibitor, the chemical contradiction that an efficient alkaline purification process is incompatible with a nano-emulsion stable system is solved, physical aging is inhibited, and an unexpected technical effect is obtained. The invention also discloses an O / W type cream containing the nano emulsion.

The invention discloses a degradable PHA / PU composite water-based barrier coating and a coated paper product, and belongs to the field of biodegradable polymer coatings. The coating composition comprises a high proportion of polyhydroxyalkanoates as a barrier phase and a bio-based polyurethane as a toughening and heat sealing phase. The key innovation lies in that the cooperation of rigid barrier and flexible functions is realized by accurately regulating and controlling the ratio of two phases and adopting bio-based crosslinking, and the problem that the barrier property, the heat sealability and the flexibility of a traditional single material are difficult to consider at the same time is solved under the condition of low coating amount. The invention provides a full-life-cycle green packaging solution, aims to replace a polyethylene spraying film and a fluorine-containing coating, and has a remarkable application value in the field of food packaging.

To provide a medical tissue reconstruction material, which is involved in tissue reconstruction and exhibits superior tissue affinity, tissue conductivity, and mechanical properties, and a method for producing the same.SOLUTION: The present invention provides a composite comprising a biodegradable polymer and calcium phosphate exhibiting one of scaly, acicular, grooved, or linear recessed structures, and / or calcium carbonate containing vaterite, the composite meeting specific conditions.SELECTED DRAWING: Figure 3

The application discloses degradable PHA / PU composite water-based barrier coating and coated paper products, and belongs to the field of biodegradable polymer coating. The coating composition contains a high proportion of polyhydroxyalkanoate as a barrier phase and a bio-based polyurethane as a toughening and heat-sealing phase. The key innovation is that by precisely controlling the ratio of the two phases and using bio-based cross-linking, the synergy of rigid barrier and flexible function is achieved, and the problem that the barrier property, heat-sealing property and flexibility of traditional single material are difficult to balance is solved at low coating amount. The application provides a full life cycle green packaging solution, which aims to replace polyethylene shower film and fluorine-containing coating, and has significant application value in the field of food packaging.

The present application relates to a sustained release delivery composition of a vesicular monoamine transporter type 2 (VMAT2) inhibitor, a deuterated derivative thereof, a pharmaceutically acceptable salt thereof, an active metabolite thereof, or a prodrug thereof for treatment of hyperkinetic movement disorders including, but not limited to, tardive dyskinesia (TD), Huntington's disease (HD) chorea, tremors, dystonia, chorea, tics, myoclonus, stereotypies, restless legs syndrome, and various other disorders with abnormal involuntary movements. The present application also relates to a sustained release delivery composition of an antipsychotic agent, a pharmaceutically acceptable salt thereof, an active metabolite thereof, or a prodrug thereof for treatment of schizophrenia, bipolar disorder, and other psychiatric diseases or disorders. The method of making or using the composition is also disclosed.

The present invention relates to a preparation method of a collagen filler for injection. Non-crosslinked collagen, crosslinked collagen, and biodegradable polymer microspheres are compounded and mixed in a certain proportion to achieve an immediate filling effect. The biodegradable polymer microspheres play a long-term role, and the amino acid components degraded from collagen in the early and middle stages can become nutrients that stimulate the production of collagen regeneration by polyester microspheres. In the present invention, the crosslinked collagen has a high yield and less water loss through a gradient irradiation crosslinking technique. The non-crosslinked collagen gel can provide a microenvironment for nutritional repair and a filling effect in the early stage, the crosslinked extracellular matrix can provide a repair microenvironment in the middle stage of filling, and the degradation of polyester microspheres in the later stage promotes collagen regeneration, enabling the skin to have a good microenvironment throughout the repair cycle and increasing skin elasticity.

The present invention relates to a composition comprising an aqueous dispersion of biodegradable polymer particles, a method of preparing the composition, and a method of preparing a coated substrate comprising the composition. The composition is useful as a coating applied to a substrate, particularly a paper substrate. The coated paper is useful as a single layered barrier coated paper or paperboard.

A cellularized nerve regeneration graft is disclosed that includes an electrospun biodegradable polymer conduit having an exterior surface and an interior luminal space, a plurality of fibroblasts seeded to the exterior surface of the conduit, and a system filling the interior luminal space of the conduit. The system may include a hydrogel matrix or augmented hydrogel matrix and Schwann cells. The cellularized nerve regeneration graft may be used in the repair of peripheral nerve injuries. Methods of making the cellularized nerve regeneration graft are also disclosed.

The invention relates to a high-strength and high-toughness polylactic acid composite material and a preparation method thereof, and belongs to the technical field of biodegradable high polymer materials. The formula of the polylactic acid composite material comprises the following components in parts by weight: 70-80 parts of polylactic acid, 5-10 parts of modified cellulose nanocrystals, 3-5 parts of modified montmorillonite, 1-2 parts of a plasticizer and 0.5-1.5 parts of an antioxidant. A preparation method of the modified cellulose nanocrystals comprises the following steps: adding cellulose nanocrystals into deionized water, and carrying out ultrasonic treatment to obtain a dispersion liquid A; and sequentially adding 0.5-1 M tannic acid solution at the temperature of 60 DEG C into the dispersion liquid A, cooling to room temperature, dropwise adding 3 M octadecylamine-ethanol solution, washing with ethanol and deionized water, and carrying out step-by-step freeze-drying treatment to obtain the modified cellulose nanocrystal, the polylactic acid composite material prepared by the preparation method has high strength, high toughness and good high temperature resistance.

Biocompatible and biodegradable polymers are provided herein as compositions, methods, and systems for making the compositions. These polymers can be adjustably stable and used in medical applications as adhesives and sealants, and in non-medical applications. Radical polymerization protocols, and two-step cationic and radical polymerization protocols, are provided for the creation of stable, polydisulfide polymers, which can be done in aqueous solution and at ambient and in vivo temperatures ranging, for example, from 0° C. to 37° C. The compositions are biocompatible and can be used as fast curing, biocompatible and biodegradable adhesives and sealants suitable for use in the consumer, industrial, military and medical arts, namely as a functional biomaterial, sustainable plastic, surgical superglue, bone adhesive, pressure-sensitive adhesive, structural adhesive, and other relevant sustainable materials with closed-loop recycling.

The invention relates to bone paste for repairing bone wounds and a preparation method of the bone paste, and belongs to the technical field of biomedical material manufacturing. The bone paste is prepared from nanoscale calcium-phosphorus biphase ceramic, biomimetic mineralized collagen fiber, biodegradable polymer, modified hyaluronic acid, beta-cyclodextrin coated recombinant human bone morphogenetic protein-7, an angiogenesis accelerant and an immunoregulation additive according to a certain proportion. The nano-scale calcium-phosphorus dual-phase ceramic is hydroxyapatite and beta-tricalcium phosphate dual-phase ceramic; the biomimetic mineralized collagenous fiber is prepared by mixing type I collagen freeze-dried fiber with hydroxypropyl chitosan and performing mineralization; the modified hyaluronic acid is hyaluronic acid-sulfydryl and hyaluronic acid-hydrazide; the angiogenesis accelerant is a polylactic acid sustained release microsphere loaded with tanshinone and hydroxyl polyethylene glycol biotin; the immunoregulation additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction capacity, promote vascularization generation and reduce the immunogenicity risk.

The present invention relates to a composition comprising an aqueous dispersion of biodegradable polymer particles, a method of preparing the composition, and a method of preparing a coated substrate comprising the composition. The composition is useful as a coating applied to a substrate, particularly a paper substrate. The coated paper is useful as a single layered barrier coated paper or paperboard.

The invention discloses an anti-fibrosis drug coating degradable woven stent for treating urethrostenosis, the stent is a hollow cylinder formed by spirally weaving wires, the wires are made of biodegradable polymer materials, the surface of the stent is coated with a drug coating, anti-fibrosis drugs are selected as the drugs, and the anti-fibrosis drug coating is made of biodegradable polymer materials. The drug coating is prepared by using an ultrasonic atomization spraying method; the biodegradable polymer material comprises one or a compound of more than one of poly L-lactic acid, poly D, L-lactic acid, poly (L-lactic acid / D, L-lactic acid), poly (glycolide / lactide), poly (glycolide-lactide), poly (L-lactic acid / caprolactone), poly (glycolide / caprolactone), poly (D, L-lactic acid / caprolactone), polydioxanone and the like. The stent body is made into a self-expanding stent by adopting a weaving method; the biodegradable ureteral stent with the drug coating has good biocompatibility, degradability and mechanical property, and has a wide market application prospect.

The invention belongs to the technical field of biodegradable high polymer materials, and particularly discloses a PLA / PPC degradable spinning material and a preparation method thereof. The PLA / PPC degradable spinning material is prepared from the following raw materials in parts by weight: 65 to 75 parts of terminated polypropylene carbonate, 15 to 20 parts of polylactic acid, 1 to 2 parts of epoxidized soybean oil, 7 to 10 parts of composite Na-montmorillonite, 3 to 5 parts of light calcium carbonate, 6 to 9 parts of rice straw fiber, 0.6 to 0.8 part of cross-linking agent, 0.2 to 0.5 part of antioxidant, 1 to 2 parts of maleic anhydride grafted PLA compatilizer, 0.07 to 0.01 part of catalyst and 0.3 to 0.5 part of silicone. Various raw materials are mixed, so that the mechanical property of the material is remarkably improved, the material has good strength and toughness, and the comprehensive performance of the material is improved.

The invention discloses a preparation method of a composite slow-release carbon source, which comprises the following steps: preparing an inner core: uniformly dry-mixing lignin powder and a quick-acting carbon source, and adding a first binder to prepare inner core particles; middle layer wrapping: alternately spraying a second binder and middle layer coating powder until the middle layer is completely wrapped to obtain double-layer particles; outer layer wrapping: alternately spraying a third binder and outer layer coating powder until the outer layer is completely wrapped to obtain three layers of particles; and spraying a biodegradable polymer solution on the surfaces of the three layers of particles to form a coating film. Through the three-layer structural design of the quick start layer, the stable maintenance layer and the long-acting guarantee layer, accurate matching of carbon source release and microbial metabolism requirements is realized. The outer-layer quick-acting carbon source quickly starts microbial activity, the middle layer provides stable and continuous carbon source supply, and the inner core ensures the tail-section treatment effect. The sequential release mechanism effectively avoids burst release waste of the carbon source, so that the utilization rate of the carbon source is greatly improved.

The invention relates to the field of high polymer material recycling, in particular to a technology for manufacturing a conveyor belt by recycling polytetrafluoroethylene. According to the process, the recycled polytetrafluoroethylene material is classified and collected according to sources and the like, impurities are removed through magnetic separation and electrostatic separation, and then microwave-assisted cleaning and activation are performed; then, a bio-based additive, a degradable polymer, a photocatalytic self-cleaning material and the like are adopted for modification treatment, so that the multi-aspect performance of the material is improved; then, the material is processed into the shape of a conveyor belt through a water-assisted injection molding or hot press molding process, and after molding, post-treatment is carried out through plant extract coating protection, recoverable and easy-to-disassemble design. The process is suitable for the requirements of conveyor belts in multiple fields, resource recycling is achieved, environmental protection and economic benefits are achieved, and the manufactured conveyor belt is excellent in performance and can meet the requirements of different working conditions.

A biodegradable composition is disclosed. The biodegradable composition includes (i) a biodegradable polymer and (ii) a cellulose ester. Films that include or are formed from the biodegradable composition, as well as articles that include a substrate and a layer of the biodegradable composition on a surface thereof, are also described.

The invention discloses an anisotropic electrostatic spinning patch with ultrasonic response and a preparation method thereof, a fiber membrane with a controllable anisotropic structure is constructed by a biodegradable polymer, antibacterial nanoparticles and a photoinitiator system through a step-by-step directional electrostatic spinning process, so that the mechanical matching property of the fiber membrane is improved; cell growth can be directionally guided and tissue regeneration can be accelerated by combining the piezoelectric material characteristics of the introduced biodegradable polymer with piezoelectric characteristics and electric field stimulation induced by the fiber topological structure; meanwhile, a zwitterionic coating is generated on the surface of the fiber membrane in situ by utilizing a single-sided photocuring technology, and an anti-adhesion function is realized on the single side of the fiber membrane. Furthermore, the soft tissue repair patch which has multiple functions of adjustable mechanical property, infection resistance, adhesion resistance and the like and has better structural mechanical suitability, function integration and tissue regeneration guiding capability is prepared by adopting the anisotropic electrostatic spinning patch with ultrasonic response.

To provide biodegradable polymer composite materials in which decomposition ability of biodegradable polymers by enzymes is maintained even in water.SOLUTION: A biodegradable polymer composite material 1 comprises a substrate 10 containing a biodegradable polymer, an enzyme 12 having a decomposing activity for the biodegradable polymer supported on the substrate 10, and a biodegradable polymer coating 20 provided on the substrate 10.SELECTED DRAWING: Figure 1

In one aspect, there is provided a composition comprising a waste particulate material and a biodegradable polymer; wherein the biodegradable polymer comprises a thermoplastic polymer; a weight portion of said biodegradable polymer within said composition is between 10 and 50%; and wherein said composition is flowable at a temperature between 100 and 220° C.. Furthermore, shaped articles derived from the composition and method of manufacturing thereof are also provided.

The present invention relates to a biodegradable polymer composition formed by waterborne radical emulsion polymerization of monomers selected from ethylenically unsaturated monomers characterized in that, the polymer composition is composed of at least two different populations of particles, said populations differing in average particle size value by at least a factor of 1.5, wherein (a) a population P1 is constituted by particles having an average particle size of greater than 250 nanometers, said particles being constituted of polymer chains predominantly built of ethylenically unsaturated monomers, further comprising 0.5 to 50% by C weight of oligomer lactide 2-hydroxyethyl, methacrylate terminated macromonomer, based on the total weight of the monomers, and (b) a population P2, distinctive of P1 by average particle size value, is constituted by particles having an average particle size of less than or equal to 250 nanometers, said particles being constituted of polymer chains predominantly built of ethylenically unsaturated monomers, further comprising 0.5 to 50% by weight of oligomer lactide 2-hydroxyethyl, methacrylate terminated macromonomer, based on the total weight of the monomers, wherein said two different populations jointly constitute at least 70% by weight, preferably 90% by weight, of the total polymeric content within said composition.

The invention belongs to the technical field of medicines, and particularly relates to a donepezil sustained release preparation and a preparation method thereof, the method comprises the following steps: mixing donepezil, a biodegradable polymer, an amphiphilic polymer and a stabilizer, shearing, curing, and freeze-drying to obtain donepezil microsphere freeze-dried powder. The donepezil sustained release preparation can realize controllable and sustained release of donepezil, the microspheres are good in character and high in stability, meanwhile, the preparation method is simple and convenient, and industrial large-scale production is easy to realize.

A biodegradable polymer composition includes a biodegradable matrix polymer, and 0.1 to 5 wt. % of a processing aid having a weight average molecular weight of at least 20,000 g / mol. The processing aid is a reaction product of an acrylate monomer and, optionally, at least one copolymerizable monomer. The amount of the acrylate monomer in the processing aid ranges from 50 wt % to 100 wt %, and the amount of the copolymerizable monomer in the processing aid ranges from 0 wt % to 50 wt %. A biodegradable polymer article includes the biodegradable polymer composition. A method includes mixing a biodegradable matrix polymer with 0.1 to 5 wt. % of a processing aid, having a weight average molecular weight of at least 20,000 g / mol above melting temperatures of the biodegradable matrix polymer and the processing aid, to produce a biodegradable polymer composition.

The invention provides a bone repair material with a long-acting anti-inflammatory function. The bone repair material comprises a core material composed of an anti-inflammatory material, a first wall material composed of a biodegradable polymer and a second wall material composed of a biodegradable inorganic substance. The anti-inflammatory drug wall material is wrapped by two layers of wall materials, degradation of polylactic acid and release of the anti-inflammatory drug are delayed, a good anti-inflammatory effect is still achieved after 28 days, and the problem of inflammation occurring in the later period of degradation of polylactic acid can be effectively solved. Besides, the second wall material composed of biodegradable inorganic matters can be used as a bone growth factor, and particularly, the nano-hydroxyapatite has better biological activity, so that the growth of osteoblasts is more facilitated, and the bone repair cost can be reduced. The anti-inflammatory material with the core-shell structure is directly prepared from the synthesized polylactic acid, high-energy-consumption procedures such as partial drying are omitted, and the provided preparation method of the bone repair material has the advantages that the process is simple, the materials are easy to obtain, the effect is obvious and the like, and has good application prospects and market prospects.

Present disclosure describes a lipid polymer hybrid nanoparticle and a method to synthesize such nanoparticles or such nanoparticle-containing compositions. The nanoparticles are made of biodegradable polymer based micellar core surrounded by lipid-based shell, wherein majority of a pharmaceutical agent is present on the inner periphery of such nanoparticles due to physical adherence with the lipid molecules. Only a minor amount of the pharmaceutical agent is encapsulated in the micellar core. Hence, the lipid-based shell becomes a primary excipient part of the nanoparticle and the biodegradable polymer containing core becomes a secondary excipient part of the nanoparticle.

The invention relates to the field of processing of full-biodegradable high polymer materials, in particular to a weather-resistant master batch and a preparation method and application thereof, and the weather-resistant master batch comprises the following components: 40-70 parts by weight of poly (butylene adipate-co-terephthalate); 10 to 20 parts of polylactic acid; 20-40 parts by weight of a supported ultraviolet absorbent; 15-25 parts by weight of modified talcum powder; 1-3 parts by weight of a light stabilizer; 1-3 parts by weight of a lubricant; 1-3 parts by weight of an antioxidant; the invention discloses a degradable mulching film and a preparation method thereof.The degradable mulching film is prepared from, by weight, 1-3 parts of a supported ultraviolet absorbent, 1-3 parts of modified talcum powder and 1-3 parts of a chain extender, the degradable mulching film comprises weather-proof master batches and poly (adipic acid) / butylene terephthalate, and the mass ratio of the weather-proof master batches to the poly (adipic acid) / butylene terephthalate is (5-15): (85-95). The ultraviolet aging resistance of the degradable mulching film is further improved.

Provided is a marine biodegradable polyol that is a compound which: includes at least two organic anions having a molecular weight of 100-5000; has a structure in which said organic anions are bonded by ionic bonds formed by a metal cation having a valence of two or higher, and includes at least two hydroxyl groups in each molecule.

It is provided a drug-eluting stent 10 comprising: an expandable structural scaffold 20 configured to resist radial compression when disposed in a lumen of a patient; a lining 30 arranged only at the central portion 21 of the structural scaffold so that the central portion is covered by the lining and the end portions 22 and 23 are free from the lining; wherein the lining comprises a biocompatible thermoplastic polymer; wherein the proximal and the distal end portions are coated with a drug-containing coating 40 comprising a biodegradable polymer and a Limus drug; and wherein the central portion of the structural scaffold and the lining are free from the Limus drug. It is also provided a process for the preparation of the drug-eluting stent.