434 results about "Biodegradable polymer" patented technology

The invention discloses a degradable PHA / PU composite water-based barrier coating and a coated paper product, and belongs to the field of biodegradable polymer coatings. The coating composition comprises a high proportion of polyhydroxyalkanoates as a barrier phase and a bio-based polyurethane as a toughening and heat sealing phase. The key innovation lies in that the cooperation of rigid barrier and flexible functions is realized by accurately regulating and controlling the ratio of two phases and adopting bio-based crosslinking, and the problem that the barrier property, the heat sealability and the flexibility of a traditional single material are difficult to consider at the same time is solved under the condition of low coating amount. The invention provides a full-life-cycle green packaging solution, aims to replace a polyethylene spraying film and a fluorine-containing coating, and has a remarkable application value in the field of food packaging.

The application discloses degradable PHA / PU composite water-based barrier coating and coated paper products, and belongs to the field of biodegradable polymer coating. The coating composition contains a high proportion of polyhydroxyalkanoate as a barrier phase and a bio-based polyurethane as a toughening and heat-sealing phase. The key innovation is that by precisely controlling the ratio of the two phases and using bio-based cross-linking, the synergy of rigid barrier and flexible function is achieved, and the problem that the barrier property, heat-sealing property and flexibility of traditional single material are difficult to balance is solved at low coating amount. The application provides a full life cycle green packaging solution, which aims to replace polyethylene shower film and fluorine-containing coating, and has significant application value in the field of food packaging.

The present application relates to a sustained release delivery composition of a vesicular monoamine transporter type 2 (VMAT2) inhibitor, a deuterated derivative thereof, a pharmaceutically acceptable salt thereof, an active metabolite thereof, or a prodrug thereof for treatment of hyperkinetic movement disorders including, but not limited to, tardive dyskinesia (TD), Huntington's disease (HD) chorea, tremors, dystonia, chorea, tics, myoclonus, stereotypies, restless legs syndrome, and various other disorders with abnormal involuntary movements. The present application also relates to a sustained release delivery composition of an antipsychotic agent, a pharmaceutically acceptable salt thereof, an active metabolite thereof, or a prodrug thereof for treatment of schizophrenia, bipolar disorder, and other psychiatric diseases or disorders. The method of making or using the composition is also disclosed.

The present invention relates to a composition comprising an aqueous dispersion of biodegradable polymer particles, a method of preparing the composition, and a method of preparing a coated substrate comprising the composition. The composition is useful as a coating applied to a substrate, particularly a paper substrate. The coated paper is useful as a single layered barrier coated paper or paperboard.

The invention relates to a high-strength and high-toughness polylactic acid composite material and a preparation method thereof, and belongs to the technical field of biodegradable high polymer materials. The formula of the polylactic acid composite material comprises the following components in parts by weight: 70-80 parts of polylactic acid, 5-10 parts of modified cellulose nanocrystals, 3-5 parts of modified montmorillonite, 1-2 parts of a plasticizer and 0.5-1.5 parts of an antioxidant. A preparation method of the modified cellulose nanocrystals comprises the following steps: adding cellulose nanocrystals into deionized water, and carrying out ultrasonic treatment to obtain a dispersion liquid A; and sequentially adding 0.5-1 M tannic acid solution at the temperature of 60 DEG C into the dispersion liquid A, cooling to room temperature, dropwise adding 3 M octadecylamine-ethanol solution, washing with ethanol and deionized water, and carrying out step-by-step freeze-drying treatment to obtain the modified cellulose nanocrystal, the polylactic acid composite material prepared by the preparation method has high strength, high toughness and good high temperature resistance.

The present invention relates to a composition comprising an aqueous dispersion of biodegradable polymer particles, a method of preparing the composition, and a method of preparing a coated substrate comprising the composition. The composition is useful as a coating applied to a substrate, particularly a paper substrate. The coated paper is useful as a single layered barrier coated paper or paperboard.

The invention discloses a preparation method of a composite slow-release carbon source, which comprises the following steps: preparing an inner core: uniformly dry-mixing lignin powder and a quick-acting carbon source, and adding a first binder to prepare inner core particles; middle layer wrapping: alternately spraying a second binder and middle layer coating powder until the middle layer is completely wrapped to obtain double-layer particles; outer layer wrapping: alternately spraying a third binder and outer layer coating powder until the outer layer is completely wrapped to obtain three layers of particles; and spraying a biodegradable polymer solution on the surfaces of the three layers of particles to form a coating film. Through the three-layer structural design of the quick start layer, the stable maintenance layer and the long-acting guarantee layer, accurate matching of carbon source release and microbial metabolism requirements is realized. The outer-layer quick-acting carbon source quickly starts microbial activity, the middle layer provides stable and continuous carbon source supply, and the inner core ensures the tail-section treatment effect. The sequential release mechanism effectively avoids burst release waste of the carbon source, so that the utilization rate of the carbon source is greatly improved.

A biodegradable composition is disclosed. The biodegradable composition includes (i) a biodegradable polymer and (ii) a cellulose ester. Films that include or are formed from the biodegradable composition, as well as articles that include a substrate and a layer of the biodegradable composition on a surface thereof, are also described.

The invention discloses an anisotropic electrostatic spinning patch with ultrasonic response and a preparation method thereof, a fiber membrane with a controllable anisotropic structure is constructed by a biodegradable polymer, antibacterial nanoparticles and a photoinitiator system through a step-by-step directional electrostatic spinning process, so that the mechanical matching property of the fiber membrane is improved; cell growth can be directionally guided and tissue regeneration can be accelerated by combining the piezoelectric material characteristics of the introduced biodegradable polymer with piezoelectric characteristics and electric field stimulation induced by the fiber topological structure; meanwhile, a zwitterionic coating is generated on the surface of the fiber membrane in situ by utilizing a single-sided photocuring technology, and an anti-adhesion function is realized on the single side of the fiber membrane. Furthermore, the soft tissue repair patch which has multiple functions of adjustable mechanical property, infection resistance, adhesion resistance and the like and has better structural mechanical suitability, function integration and tissue regeneration guiding capability is prepared by adopting the anisotropic electrostatic spinning patch with ultrasonic response.

The invention relates to a time sequence degradable orthopedic implant material which comprises a base material and a biodegradable coating formed on the surface of the base material, the surface of the base material is provided with a nanocone array microstructure, the biodegradable coating takes a biodegradable polymer as a matrix and loads a metal element for promoting bone repair, and the metal element is a metal element for promoting bone repair. And the surface of the biodegradable coating is also connected with an anti-inflammatory active factor. According to the invention, grafted anti-inflammatory active factors are matched with the biodegradable coating loaded with metal elements for promoting bone repair, and the sequential active regulation and control of the biological effect of the micro-morphology on the surface of the base material cope with effector cells in different repair stages; the time sequence regulation and control on the macrophage inflammation phenotype and bone marrow mesenchymal stem cell osteogenic differentiation in different stages of bone repair are realized, so that each stage of bone tissue repair is matched, and bone repair and osseointegration are promoted.

The invention relates to the technical field of biodegradable high polymer materials, in particular to a tear-resistant high-barrier biodegradable mulching film and a preparation method thereof, and the tear-resistant high-barrier biodegradable mulching film is prepared from the following raw materials in parts by weight: 60-90 parts of poly (butylene adipate-co-terephthalate); 10 to 40 parts of poly (propylene carbonate); 0.5-5 parts of a plasticizer; 0.05 to 0.3 part of a cross-linking agent; 0.1 to 10 parts of talcum powder; 0.1 to 2 parts of a lubricant; 0.1-1 part of an anti-blocking agent; 0.1 to 1 part of an antioxidant; 0.1 to 1 part of an anti-ultraviolet agent; 0.1-1 part of a light stabilizer; 0.1 to 1 part of an anti-hydrolysis agent; 0.1-1 part of a nucleating agent; the plasticizer is poly (1, 2-propylene glycol adipate); and the cross-linking agent is 1, 4-bis (tert-butylperoxy) diisopropyl benzene. The film has good mechanical properties and water vapor transmission amount, can be completely biodegraded, and has good aging resistance.

The present invention relates to the technical field of medicine. More specifically, the present invention relates to a microneedle composition containing an active component, and a preparation method therefor and the use thereof. The microneedle composition containing an active component contains an active component, a biodegradable polymer material, a surfactant, and the balance of a solvent, wherein on the basis of the total weight of the microneedle composition, the weight percentage of the active component is 1-15%, the weight percentage of the biodegradable polymer material is 0.1-15%, and the weight percentage of the surfactant is 0.05-5%.

The invention relates to a nerve repair guide catheter, a preparation method and application, an electrostatic spinning technology is adopted to construct a nanofiber membrane which is directionally and orderly arranged so as to guide nerve axons to directionally grow, and cell energy metabolism is promoted and tissue repair and regeneration are accelerated through metabolism and conversion of degradation products. Therefore, the nerve injury repairing effect better than that of traditional matrix materials without biological activity, such as PCL, is achieved. According to the invention, a novel solution is provided for solving the problem of insufficient biological activity of a traditional nerve conduit material by constructing a degradable high polymer material with biological activity. Therefore, the regeneration efficiency of peripheral nerve injury repair is improved, and the application prospect of the bioactive material in the fields of tissue engineering and regenerative medicine is expanded.

The invention provides a degradable and stretchable wireless sensor with a multilayer circuit and a preparation method of the degradable and stretchable wireless sensor. The wireless sensor comprises an integrated folding structure and a packaging layer, the integrated folding structure comprises a plurality of layers of snakelike wire structures and a plurality of electrode plates; the snakelike wire structure provides inductance, and the electrode plate provides capacitance; the snakelike wire structure is formed by a planar and multi-cycle snakelike wire structure formed by a biodegradable metal and biodegradable polymer composite layer through multiple times of 180-degree twisting and folding, and patterns of the snakelike wire structure are overlapped after folding so as to realize effective series connection of the inductance coils; the electrode plates are bonded with each other through a biodegradable dielectric layer; the snakelike wire structure adopts a neutral axis separation design at the arc section, namely, the wire width is divided into multiple strands. Reliable series connection of multiple layers of coils can be achieved, inductance is effectively increased, high-frequency resistance is reduced, and therefore wireless transmission performance is improved, and meanwhile the requirements for flexibility, stretchability and biodegradability are completely met.

The invention belongs to the field of biodegradable high polymer materials, and particularly relates to a preparation method of degradable antibacterial plastic and application of the degradable antibacterial plastic in meal boxes. The preparation method comprises the following steps: mixing PLA, PHA, a plasticizer and an antibacterial agent, granulating by an extruder to obtain degradable antibacterial plastic, and then carrying out injection molding to obtain the meal box. The PLA and the PHA are blended, so that the rigidity and the low cost of the PLA are retained, and the flexibility and the rapid degradability of the PHA are fused; pHA has antibacterial activity, and the dosage of extra antibacterial agents is reduced after PHA is blended with PLA; according to the invention, the porous spherical ZnO / TiO2 loaded nano Ag is used as an antibacterial agent, has a relatively high specific surface area and can efficiently sterilize, and the porous material can synchronously adsorb peculiar smell molecules or grease volatilized by food, so that the preservation time is prolonged; the meal box formed by injection molding of the plastic has excellent mechanical properties and food safety, is suitable for the field of disposable environment-friendly tableware, and solves the problems of pollution and microorganism breeding of traditional plastics.

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The invention relates to a QS-21 loaded nano adjuvant as well as a preparation method and application thereof. According to the nano adjuvant, the biodegradable polymer, cholesterol and cationic lipid entrapped QS-21 are utilized to form solid lipid particles in an O / W mode, the solid lipid particles have good dispersity, the surfaces of the solid lipid particles are positively charged, and the solid lipid particles can adsorb negatively charged antigen protein to prepare a nano adjuvant vaccine. The cholesterol in the nano adjuvant vaccine can be combined with the QS-21, so that entrapment of the QS-21 can be better realized, the safety and the stability of the nano adjuvant vaccine are improved, and the nano adjuvant vaccine has a wide application prospect in prevention of virus infection.

Described herein is a method of preparation of biodegradable composite material such as bio- composite leather from fungal fibres, preferably, mushroom fibres According to the invention, bio-composite leather is prepared by blending of fungal fibres, preferably, mushroom fibres extracted from mushroom fruiting bodies and a biodegradable polymer. The present invention also relates to the biodegradable composite material produced from fungal fibres preferably mushroom fibres or mushroom fruiting body fibres.

The application discloses an oral nano-vaccine and a preparation method and application thereof, and relates to the technical field of immunology, and specifically discloses an oral nano-vaccine which comprises a nano-particle wrapped by a biomimetic bacterial membrane vesicle and an outer layer; the nano-particle comprises an antigen and a biodegradable polymer material; the biomimetic bacterial membrane vesicle comprises an ionizable flagellar lipoprotein, an immune adjuvant, a phospholipid, a sterol lipid and a polyethylene glycol lipid; and the outer layer is a pH-responsive polymer. The oral nano-vaccine provided by the application combines the immune activation advantages of natural bacterial membrane vesicles and the precise regulation characteristics of synthetic materials, significantly improves the transmembrane penetration capacity of the antigen in the intestinal epithelium and the overall activation effect of the mucosal immune system. The oral nano-vaccine provided by the application can protect the antigen and the immune adjuvant from degradation and realize precise release in the intestinal microenvironment; and the oral nano-vaccine significantly improves the bioavailability and safety of an oral tumor vaccine, and lays a key technical foundation for clinical transformation and large-scale production of the oral tumor vaccine.

The present invention provides a composition for restoration of tissue including a biodegradable polymeric copolymer which is obtained by polymerizing a hydrophobic biodegradable polymer and a hydrophilic biodegradable polymer. The composition of the present invention has excellent tissue restoration effects because of high collagen production rate without occurrence of nodules even when injected directly into the dermis, unlike the conventional composition for restoration of tissue.

The present application belongs to the technical field of inorganic fixed luminescent materials and medical polymer elastic stents, and relates to an elastic stent composed of near-infrared inorganic stress luminescent material and organic polymer and a preparation method. The composite elastic stent provided by the present application is manufactured by using 3D printing technology, adopts biodegradable polymer material as a printing base material, and adopts inorganic near-infrared stress luminescent material as a reinforcing phase material and a luminescent base, so that the hollow, cylindrical and net-shaped polymer composite elastic stent required is printed on a cylindrical surface base, and the composite elastic stent can be applied to real-time monitoring of the internal microenvironment of a blood vessel after an operation.

To provide an aerosol composition that enables a biodegradable polymer thin film to be readily formed on a target material with high productivity.SOLUTION: An aerosol composition contains a propellant containing dimethyl ether, and a biodegradable polymer that is soluble in the dimethyl ether.SELECTED DRAWING: None

Use of a spreading granulate as infill granulate for grass and artificial turf pitches, wherein the infill granulate comprises a polymer matrix with a proportion of between 10 wt.% and 100 wt.% of at least one biodegradable polymer and at least one filler from the group of natural fillers embedded in the polymer matrix with the at least one biodegradable polymer, characterized in that the infill granulate comprises at least one filler from the group of crushed fruit kernels with a higher hardness than that of the polymer matrix.

The present invention relates to a polymer composite material comprising: a. a biodegradable polymer in an amount of 1 to 98% by weight of the total weight; b. micronized feldspar in an amount of at least 1% by weight of the total weight; c. a starch and / or protein-containing material in an amount of at least 1% by weight of the total weight; d. optional additives; and e. an optional plasticizer for the starch and / or protein-containing material in an amount of less than 5% by weight of the starch and / or protein-containing material.

The present disclosure relates to biodegradable polymeric microspheres comprising a biodegradable polymer and an immunotherapeutic agent selected from the group consisting of a poly ADP ribose polymerase inhibitor (PARP inhibitor) and / or a Toll-like receptor (TLR) agonist, wherein (a) 50% of the total amount of the immunotherapeutic agent in the biodegradable polymer microspheres is released from the biodegradable polymer microspheres to a PBS solution containing 0.05% of Tween 20 at 37 DEG C at a certain time point between 3 days and 14 days; (b) releasing the immunotherapeutic agent with the dry weight of 1 mg / g to 100 mg / g from the biodegradable polymer microspheres to a PBS solution containing 0.05% of Tween 20 at 37 DEG C at a certain time point between 3 days and 14 days; or (c) satisfies both (a) and (b). Other aspects of the present disclosure relate to methods of using such microparticles and kits comprising such microparticles.

To provide a filament for 3D printers that has both high printability and transparency.SOLUTION: The present invention provides a filament for a 3D printer, which comprises a polyester copolymer, does not comprise a water-soluble polymer or a biodegradable polymer different from the polyester copolymer, and has a melting enthalpy of greater than 0.0 J / g and not greater than 10.0 J / g.SELECTED DRAWING: None

Disclosed is a polymer composition including a polyester copolymer and a biodegradable polymer, wherein the polyester copolymer includes two types of ester bond-forming monomer residues as main structural units, when the two types of ester bond-forming monomers are defined as “monomer A” and “monomer B”, respectively, the polyester copolymer satisfies (1) to (3) below, the biodegradable polymer has a melting point of 100° C. or higher, and the biodegradable polymer is included in an amount of 0.1% by weight or more and less than 30% by weight in 100% by weight of the total of the polyester copolymer and the biodegradable polymer. The present invention provides a polymer composition having low Young's modulus and high tensile strength. (1) An R value represented by the following formula is 0.45 or more and 0.99 or less. R=[AB] / (2[A][B])×100, where [A]: molar fraction (%) of monomer A residues in the polyester copolymer, [B]: molar fraction (%) of monomer B residues in the polyester copolymer, and [AB]: molar fraction (%) of a structure in which monomer A residues and monomer B residues are adjacent to each other (A-B and B-A) in the polyester copolymer. (2) A crystallization rate of monomer A residues and a crystallization rate of monomer B residues are less than 14%. (3) A melting point is lower than 100° C. or a clear melting point does not exist.

Methods of forming compostable polymeric materials and compostable polymeric materials formed through the methods are provided herein. In an embodiment, a method includes blending a biodegradable polymer chosen from a biodegradable polyester, a biodegradable polysaccharide, or combinations thereof, with a polymer-degrading enzyme and a plasticizer to form an intermediate composition. The intermediate composition is gel extruded to form the compostable polymeric material. In an embodiment, a compostable polymeric material is formed by a method comprising the recited steps.

The present invention relates to a fully biodegradable composite structure, which is in the form of a sheet in a specific form and can be used for producing artificial leather, said composite structure having a surface layer formed with a biodegradable polymer as a polymer component, a composite layer made of a biodegradable polymer composition, the fabric layer is made of a biodegradable textile base material; and the surface layer is made of a biodegradable polymer which can be dispersed in water. The invention also relates to a method for producing such a composite structure, in which the composite structure can impart a desired surface structure, a method for composting the composite structure, and a method for separating the layers of the composite structure, in which the composite structure is treated by an organic solvent, which can selectively dissolve one or more layers in the composite structure.

Methods of forming biodegradable polymeric films, biodegradable polymeric films produced through the methods, and composite articles comprising the biodegradable polymeric films are provided herein. In an embodiment, the methods include the steps of mixing a heterogeneous additive and a plasticizer to form a slurry, mixing the slurry and a biodegradable polymer to form a dough, and gel extruding the dough to form an extrudate. In an embodiment, a biodegradable polymeric film is formed by a method comprising the recited steps. In an embodiment, a composite article comprises the biodegradable polymeric film and an additional layer having a composition different from that of the biodegradable polymeric film.