11 results about "Valerate" patented technology

The application discloses cupriavidus capable of producing polyhydroxyalkanoate by using various carbon sources such as ethanol and application thereof. Cupriavidus The strain sp.ZWJ01 has a preservation number of CGMCC No.37462 in the China General Microbiological Culture Collection Center. The strain can grow and accumulate poly-3-hydroxybutyric acid ester by using various substances such as ethanol, volatile fatty acid and sugar as carbon sources; can grow by using mixed carbon sources of ethanol+propionic acid or ethanol+valeric acid and accumulate poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid ester) in cells; and can grow by using mixed carbon sources of ethanol+gamma-butyrolactone or ethanol+1,4-butanediol and accumulate poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) in cells, and has a good application prospect.

This invention discloses a method for synthesizing α-hydroxycarboxylic acid compounds. The method includes the following steps: adding a reaction substrate, a photosensitizer, and a base to a dry reaction tube; then adding a solvent and additives under a CO2 atmosphere; and reacting under visible light irradiation. After the reaction is complete, the reaction system is acidified and quenched, and then purified to obtain the product, the α-hydroxycarboxylic acid compound. The photosensitizer includes Ir(ppy)2(dtbbpy)PF6 and 3DPA2FBN; the base is potassium tert-butoxide, cesium carbonate, or potassium tert-valerate; the additives are N,N-diisopropylethylamine and chlorosilane; and the reaction substrate is an aldehyde or ketone compound. This invention provides a highly efficient and selective synthesis of α-hydroxycarboxylic acid compounds under visible light induction and a CO2 atmosphere. The reaction conditions of this invention are mild, the reactant range is broad, the selectivity is good, and it can be scaled up to the gram scale.

This invention belongs to the fields of medicinal chemistry and organic synthesis, specifically relating to a stable 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate and its application in the preparation of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. This invention effectively solves the technical bottlenecks of poor stability, difficulty in purification, and storage by converting unstable free 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate into a specific organic acid salt form. More importantly, this invention discovers that this organic acid salt can be directly used as a reaction intermediate, and can be used efficiently in subsequent amide condensation reactions with cholic acid or its active derivatives without the separation of free amines. This method significantly improves the purity and yield of the key intermediate and its downstream product 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. The process is stable and simple to operate, providing a stable, controllable, and economical preparation route for the industrial production of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid, a key active pharmaceutical ingredient in the liver cancer prodrug LLC-202.

The application discloses a method for preparing methyl valerate by butene carbonylation, and belongs to the field of catalytic chemistry. Raw materials containing butene, carbon monoxide and methanol are introduced into a reactor loaded with a solid acid catalyst, and a product containing methyl valerate is obtained through reaction. The application provides a new method for preparing methyl valerate by butene carbonylation with a solid acid catalyst. The method for preparing methyl valerate has the advantages of cheap and easily obtained raw materials, small corrosion of the system, easy separation of the product, less waste discharge, easy engineering of the fixed bed process, and suitability for single large-scale production.

Methods and consumer products for detecting a metabolite, the method comprising: testing a urine sample from a subject for a metabolite selected from the group consisting of ascorbate, dehydroascorbate, CEHC-sulfate, CEHC-taurine, CEHC-glucronide, pantoate, 5-amino valerate, galactonate, phenylacetylalanine, methylcatecholsulfate, phenylacetylglutamine, carboxysuccinate, carboxyethylvaline, arabinose, threonate, methylcrotonylglycine, glucuronate, carboxyethylisoleucine, glycoursodeoxycholate, leucylalanine, lithocholatesulfate, allo-threonine, cholic, glucuronide and combinations thereof; and producing a metabolic profile for the metabolite.

The invention discloses a 4-trimethylsiloxy-5-cyano pentanamide / valerate compound and a preparation method of the 4-trimethylsiloxy-5-cyano pentanamide / valerate compound. The preparation method comprises the following steps: directly starting from non-activated olefin alkenyl silane, firstly, carrying out 1, 3-dipolar cycloaddition reaction on the non-activated olefin alkenyl silane and 1, 1-dibromo formaldoxime under the conditions that potassium carbonate is taken as alkali and ethyl acetate is taken as a solvent to generate 3-bromo-5-(trimethylsilyl)-4, 5-dihydroisoxazole; then, in a nitrogen atmosphere, by utilizing a photooxidation reduction catalysis strategy and by virtue of the capability of capturing halogen atoms of excited state [Au2 (dppm) 2] Cl2, debromination cracking ring opening of the 3-bromo-5-(trimethylsilyl)-4, 5-dihydroisoxazole is realized, and alpha-oxy carbon free radicals can be generated in the next free radical 1, 2-silicon migration process, so that the 3-bromo-5-(trimethylsilyl)-4, 5-dihydroisoxazole can be obtained through debromination cracking ring opening of the 3-bromo-5-(trimethylsilyl)-4, 5-dihydroisoxazole. And the free radical sequentially reacts with acrylamide or acrylic ester and a hydrogen donor to finally obtain the 4-trimethylsiloxy-5-cyano valeramide / valerate compound. The materials required by the method are commercialized or can be prepared through simple organic synthesis, visible light is used as an energy source, the method can be carried out at room temperature, and the method has the characteristics of mild conditions, greenness, environmental protection and the like.

The present application relates to the technical field of phase change material, and provides a phase change cold storage material, a preparation method and application thereof, the phase change cold storage material comprises two or more components; the components comprise ester substances; the ester substances are selected from one or a combination of two or more of butyl valerate, ethyl butyrate and n-propyl acetate. By screening specific ester substances, a mixed medium with a eutectic temperature less than or equal to -90 DEG C can be obtained, so that the energy storage requirement in the temperature zone below -90 DEG C can be realized. The selected substances have the characteristics of high safety and excellent thermal performance, and can be used in the fields of liquefied natural gas storage, liquefied natural gas transportation, medicine storage, medicine transportation or power load management. Meanwhile, the phase change cold storage material preparation method is simple, low in cost and has a high market application prospect.

This invention provides a method for preparing valerate esters by carbonylation of mixed butenes, relating to the field of valerate ester preparation technology. The invention involves pre-preparing a catalyst precursor, ligand, mixed butenes, and an organic solvent with carbon monoxide in a pre-preparation device. The pre-prepared catalyst stream is then continuously fed into a reactor along with mixed butenes, an alcohol, and carbon monoxide for a hydrogen esterification reaction. Simultaneously, a separator separates the valerate ester product, recovers the alcohol, and recycles the catalyst solution. This method achieves efficient and continuous preparation of valerate esters from mixed butenes under mild conditions, offering advantages such as high raw material utilization, long catalyst lifespan, low production cost, and broad prospects for industrial application.

The invention discloses a preparation method of diflucolone or diflucolone valerate, which comprises the following steps: in an inert protective atmosphere, carrying out reduction reaction on flumethasone and a reducing agent in a solvent to obtain the diflucolone, the preparation method comprises the following steps: in an inert protective atmosphere, carrying out acylation reaction on difluorocolone and an acylation reagent in a solvent in the presence of a base catalyst to obtain the difluorocolone valerate. The specific solvent is adopted in the reduction reaction, the problems that in the prior art, reaction by-products are large, raw material reaction is not thorough, the yield is low, and the production cost is high are solved, the product purity and the overall yield are obviously improved, and the production cost is reduced. According to the method, inorganic alkali and acetone are used as a solvent in the acylation reaction, the solvent can be recycled after post-treatment, the method is environment-friendly, 11-site hydroxyl is prevented from being acylated under the acylation condition, byproducts are effectively controlled, and the purity and yield of the product are improved.

This invention relates to the field of agricultural chemical storage stability control technology, and particularly to a carbon steel lined plastic storage tank device and method for storing valerate preparations. The method includes: S1, obtaining initial parameters for the batch to be stored; S2, loading the valerate preparation into the carbon steel lined plastic storage tank and sealing the tank; S3, obtaining detection data sequences of pH value, dissolved oxygen mass concentration, and storage temperature changing over time; S4, establishing a valerate decomposition kinetic model corresponding to the current batch; S5, predicting the predicted mass fraction of the active ingredient in valerate at the end of the planned storage period, and performing a storage condition adjustment step when the predicted mass fraction is lower than a preset lower limit; S6, correcting the parameters of the valerate decomposition kinetic model using the updated detection data sequence. This invention improves storage stability by online monitoring of valerate pH, dissolved oxygen, and temperature, establishing a kinetic model to predict the content at the end of the period, and regulating storage conditions.

Methods and consumer products for detecting a metabolite, the method comprising: testing a urine sample from a subject for a metabolite selected from the group consisting of ascorbate, dehydroascorbate, CEHC-sulfate, CEHC-taurine, CEHC-glucronide, pantoate, 5-amino valerate, galactonate, phenylacetylalanine, methylcatecholsulfate, phenylacetylglutamine, carboxysuccinate, carboxyethylvaline, arabinose, threonate, methylcrotonylglycine, glucuronate, carboxyethylisoleucine, glycoursodeoxycholate, leucylalanine, lithocholatesulfate, alio-threonine, cholic, glucuronide and combinations thereof; and producing a metabolic profile for the metabolite.