6 results about "Valerate" patented technology

The application discloses cupriavidus capable of producing polyhydroxyalkanoate by using various carbon sources such as ethanol and application thereof. Cupriavidus The strain sp.ZWJ01 has a preservation number of CGMCC No.37462 in the China General Microbiological Culture Collection Center. The strain can grow and accumulate poly-3-hydroxybutyric acid ester by using various substances such as ethanol, volatile fatty acid and sugar as carbon sources; can grow by using mixed carbon sources of ethanol+propionic acid or ethanol+valeric acid and accumulate poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid ester) in cells; and can grow by using mixed carbon sources of ethanol+gamma-butyrolactone or ethanol+1,4-butanediol and accumulate poly(3-hydroxybutyric acid-co-4-hydroxybutyric acid) in cells, and has a good application prospect.

This invention belongs to the fields of medicinal chemistry and organic synthesis, specifically relating to a stable 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate and its application in the preparation of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. This invention effectively solves the technical bottlenecks of poor stability, difficulty in purification, and storage by converting unstable free 3-aminocyclobutane-1,1-dicarboxylic acid diethyl oxalate into a specific organic acid salt form. More importantly, this invention discovers that this organic acid salt can be directly used as a reaction intermediate, and can be used efficiently in subsequent amide condensation reactions with cholic acid or its active derivatives without the separation of free amines. This method significantly improves the purity and yield of the key intermediate and its downstream product 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid. The process is stable and simple to operate, providing a stable, controllable, and economical preparation route for the industrial production of 3-(cholate-valerate)cyclobutane-1,1-dicarboxylic acid, a key active pharmaceutical ingredient in the liver cancer prodrug LLC-202.

The application discloses a method for preparing methyl valerate by butene carbonylation, and belongs to the field of catalytic chemistry. Raw materials containing butene, carbon monoxide and methanol are introduced into a reactor loaded with a solid acid catalyst, and a product containing methyl valerate is obtained through reaction. The application provides a new method for preparing methyl valerate by butene carbonylation with a solid acid catalyst. The method for preparing methyl valerate has the advantages of cheap and easily obtained raw materials, small corrosion of the system, easy separation of the product, less waste discharge, easy engineering of the fixed bed process, and suitability for single large-scale production.

This invention provides a method for preparing valerate esters by carbonylation of mixed butenes, relating to the field of valerate ester preparation technology. The invention involves pre-preparing a catalyst precursor, ligand, mixed butenes, and an organic solvent with carbon monoxide in a pre-preparation device. The pre-prepared catalyst stream is then continuously fed into a reactor along with mixed butenes, an alcohol, and carbon monoxide for a hydrogen esterification reaction. Simultaneously, a separator separates the valerate ester product, recovers the alcohol, and recycles the catalyst solution. This method achieves efficient and continuous preparation of valerate esters from mixed butenes under mild conditions, offering advantages such as high raw material utilization, long catalyst lifespan, low production cost, and broad prospects for industrial application.

This invention relates to the field of agricultural chemical storage stability control technology, and particularly to a carbon steel lined plastic storage tank device and method for storing valerate preparations. The method includes: S1, obtaining initial parameters for the batch to be stored; S2, loading the valerate preparation into the carbon steel lined plastic storage tank and sealing the tank; S3, obtaining detection data sequences of pH value, dissolved oxygen mass concentration, and storage temperature changing over time; S4, establishing a valerate decomposition kinetic model corresponding to the current batch; S5, predicting the predicted mass fraction of the active ingredient in valerate at the end of the planned storage period, and performing a storage condition adjustment step when the predicted mass fraction is lower than a preset lower limit; S6, correcting the parameters of the valerate decomposition kinetic model using the updated detection data sequence. This invention improves storage stability by online monitoring of valerate pH, dissolved oxygen, and temperature, establishing a kinetic model to predict the content at the end of the period, and regulating storage conditions.

Methods and consumer products for detecting a metabolite, the method comprising: testing a urine sample from a subject for a metabolite selected from the group consisting of ascorbate, dehydroascorbate, CEHC-sulfate, CEHC-taurine, CEHC-glucronide, pantoate, 5-amino valerate, galactonate, phenylacetylalanine, methylcatecholsulfate, phenylacetylglutamine, carboxysuccinate, carboxyethylvaline, arabinose, threonate, methylcrotonylglycine, glucuronate, carboxyethylisoleucine, glycoursodeoxycholate, leucylalanine, lithocholatesulfate, alio-threonine, cholic, glucuronide and combinations thereof; and producing a metabolic profile for the metabolite.