37 results about "Blood compatible" patented technology

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.

The invention provides blood compatible nanomaterials, biomaterials prepared therewith and blood compatible medical devices fabricated using the biomaterials of the invention. The invention further provides methods of making and using the nanomaterials, biomaterials and medical devices of the invention for the diagnosis, prevention and treatment of medical conditions. The invention further provides methods of using room temperature ionic liquids to make blood compatible nanomaterials.

The invention discloses a POSS (Polyhedral Oligomeric Silsesquioxane) fluorosilicone acrylate-polyurethane blood compatible coating and a preparation method thereof. The coating is formed on a medical polyvinyl chloride sheet by using a (methyl)acryloxy oligo-POSS fluorosilicone acrylate copolymer and one or two curing agents selected from hexamethylene diisocyanate and isophorone diisocyanate. The preparation method comprises the steps of preparing the POSS fluorosilicone acrylate copolymer into a mixed solution of dichloromethane or ethyl acetate and n-hexane; spraying the solution on the surface of medical polyvinyl chloride through a spray gun to form the coating with good blood compatibility. The POSS fluorosilicone acrylate-polyurethane blood compatible coating and the preparation method thereof have the advantages that the preparation method is simple in process, easy to obtain raw materials and easy to realize industrial and large-scale production; the prepared blood compatible coating has good film forming property and hydrophobicity, favorable blood compatibility and relatively high practical values.

The invention discloses cyclic biodegradation aliphatic polyester and a preparation method thereof. The cyclic biodegradation aliphatic polyester is prepared through combination of ring opening polymerization and click chemical reaction. The preparation method comprises the following steps of adopting small-molecule alcohol containing acetylene alkynyl as an initiator to initiate ring opening polymerization of a cyclic ester monomer so as to prepare single-end alkynylation biodegradation aliphatic polyester; enabling the single-end alkynylation biodegradation aliphatic polyester and acid halide and sodium azide to perform reaction sequentially to prepare linear biodegradation aliphatic polyester containing the acetylene alkynyl and azide group; and finally, preparing the cyclic biodegradation aliphatic polyester through the click chemical reaction. The ring size of the cyclic biodegradation aliphatic polyester is controllable, reaction conditions are moderate, and reaction products are pure. In addition, the cyclic biodegradation aliphatic polyester has a topological structure and performance which are different from a structure and the performance of corresponding linear biodegradation aliphatic polyester and can be well applied in the aspects of sustained or controlled release of drug carriers, scaffolds for tissue engineering, blood compatible materials and the like.

A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.

A labeling system to ensure that blood products are compatible with a patient's blood type. A blood product housing, which is attached to a blood product, comprises a plurality of block-like projections and recesses corresponding to the antigens/antibody characteristics of a blood product. A patient housing, secured to the patient, comprises a plurality of mirror image three-dimensional block-like projections and recesses corresponding to the antigen/antibody characteristics of the patient's blood. If the blocks and recesses of the housings mate and seat to one another this confirms the blood product is compatible with the blood of the patient. If the blocks and recesses of the housings do not mate and seat to one another this confirms the blood product is not compatible with the blood of the patient.

The invention discloses a thrombus filter capable of realizing delayed recovery and a preparation method of the thrombus filter and particularly discloses a blood compatible coating. The blood compatible coating comprises a polyacrylic acid layer and a polyethylene glycol layer, and 2-methacryloyloxyethyl phosphorylcholine is covalently linked with the surface of the polyethylene glycol layer. Theinvention further discloses medical apparatus such as the thrombus filter coated with the blood compatible coating. According to the technical scheme, thrombogenesis and endothelial tissue growth canbe better inhibited. The whole surface coating is adjustable in thickness and surface grafting amount and can well bear stress and strain actions in apparatus assembly and release processes, molecules are firmly combined without falling off, and mechanical properties of the apparatus are not affected.

The invention discloses a polysiloxane-polyarylester block copolymer, preparation thereof and applications thereof. The polysiloxane-polyarylester block copolymer is showed in the following formula. The polysiloxane-polyarylester block copolymer has low surface energy, strong hydrophobicity and an obvious microphase separation structure, and has great application value in the field of blood compatible materials. According to a preparation process of the block copolymer, a fluorine-containing/fluorine-free polyarylester having terminal alkenes, and a fluorine-containing/fluorine-free polysiloxanes having terminal hydrogens are used as raw materials, one or over two types of tetrahydrofuran, isopropanol, tolune and benzotrifluoride are used as solvent; and the block polymer is synthesized by hydrosilylation under the catalytic action of a catalyst 1,3-divinyl-1,1,3,3-tetramethyldisiloxane platinum (0) or chloroplatinic acid. The synthetic method is simple with mild and controllable reaction conditions, and is prone to industrial production.

The invention discloses a hemoglobin microcapsule and its preparation method. The hemoglobin microcapsule is a biocompatible and blood-compatible hemoglobin microcapsule blood substitute prepared through Schiff base bond layer-by-layer assembling, the capsule wall components used by the hemoglobin microcapsule comprise a biocompatible and biodegradable polysaccharide derivative and hemoglobin, Schiff base bonds are formed between the components of the capsule wall, and a toxic crosslinking agent is not used in the invention. The hemoglobin microcapsule blood substitute obtained in the invention has the advantages of good stability, biological compatibility, blood compatibility, biodegradability, non-toxicity, no use of the crosslinking agent, and adjustable dimension, structure and functions.

The invention discloses a POSS (Polyhedral Oligomeric Silsesquioxane) fluorine-silicon acrylate block copolymer as well as a preparation method and application thereof. The copolymer is composed of a PDMS (Polydimethylsiloxane) block and an FAC (Fluorinated Acrylate) block and has a structural formula shown in the specification. According to the preparation method, free-radical polymerization is carried out on acrylate monomers, hydroxyl-containing acrylic functional monomers, fluorinated functional acrylic monomers and (methyl) propylene acyloxy oligomeric silsesquioxane by utilizing a polydimethyl siloxane macromolecular initiator to obtain the POSS fluorine-silicon acrylate block copolymer. The preparation method disclosed by the invention has the advantage that the raw materials are easily available and the experimental conditions are gentle; the surface of the block copolymer has a micro-phase separating structure, so that the block copolymer has the characteristics of low surface energy, strong base material adhesive force and the like after being formed into a film, has certain crudeness and hardness, and is applied to a blood compatible material.

The invention discloses a preparation method of a blood-compatible polypropylene non-woven fabric, the preparation method comprises the following operation steps: (1) dimethylamine and glycidyl etherare subjected to addition reaction, and then the mixture is purified to obtain a component A; (2) N-[2] [bis (carboxymethyl)) amino ] ethyl ]-N-(2-hydroxyethyl)) glycinate trisodium is subjected to self-polymerization reaction to obtain a component B; (3) a polypropylene non-woven fabric is cleaned, then is modified liquid by a modification liquid; and (4) the component A and the component B are loaded on the surface of the modified polypropylene non-woven fabric so as to obtain the blood-compatible polypropylene non-woven fabric. The blood-compatible polypropylene non-woven fabric prepared bythe method disclosed by the invention is excellent in mechanical property and high in machinability, the prepared blood-compatible polypropylene non-woven fabric is non-toxic, environment-friendly, high in biochemical stability and long in service life, especially is strong in surface polarity, high in surface energy and remarkable in hydrophilicity, and has extremely excellent anti-protein adsorption capacity and anti-platelet adhesion capability.

The disclosure features blood compatible articles and methods of making the articles. The methods include providing a substrate and forming a rough surface on the substrate. The rough surface includes a plurality of three-dimensionally curved features each having a radius of curvature of less than about 50 nm. The surface includes a sufficient concentration of features per unit area to limit blood coagulation activity on the substrate and to limit the number of platelets that adhere to the surface when the substrate is exposed to blood.

The present invention relates to the medical industry. In particular, it is related to a polyvinyl chloride polymer (PVC) functionalized for medical use, which is flexible and compatible with blood. Specifically, this invention is related to a biomolecule-functionalized PVC and its production method, in order to produce a flexible and blood-compatible polymer for medical use.

The invention relates to a device (4) in an extracorporeal perfusion system (2), the invention relates to a device for removing, in particular negatively charged harmful substances (38), the method comprises the following steps: removing blood (44) containing plasma (46) and a cell component (48); the filter comprises a shell (12) and a plurality of hollow fibers (14) arranged in the shell (12), the hollow fibers are configured to allow blood (44) to flow through. Wherein the hollow fibers (14) each have a plurality of pores (34), the hole is arranged to be a hole, wherein the hollow fibers (14) are arranged in such a way that plasma (46) of blood (44) can flow through the holes (34) from the inside of the hollow fibers (14) to the outside of the hollow fibers (14), at the same time, the hollow fibres (14) are subjected to, in particular chemical, modification or pre-treatment, such that they have a functional surface (36) that can bind to and remove the harmful substances (38) from the blood (44). The inner side surface (40) of the hollow fiber (14) is also provided with, in particular, a blood-compatible, anticoagulant, coating (50), which is designed to prevent damage to the cellular components (48) of the blood (44) when the blood (44) flows through the hollow fiber (14). The invention also relates to an extracorporeal perfusion system (2) comprising said device (4) and toa method for producing said device (4).

A blood compatible oriented polymer-liquid crystal film is prepared from the polymer (medical polyether-type polyurethane and medical polyvinyl chloride) and the liquid crystal compound (cholesterin-type liquid crystal) through dissolving them is solvent, pouring the solution in a lower copper plate frame connected to an electric pole, putting another copper plate connected another electric pole on it, applying a voltage to generate an electric field for volatalizing the solvent to obtain a film, and vacuum drying. Its advantages are anticoagulation performance able to meet the requirement of human organs, and high biologic compatibility to human body.

Disclosed herein is a medical device, comprising a covalently-bonded heparin coating on a substrate, where the covalently bonded heparin coating is the reaction product of (a) an isocyanate-bearing material on or covalently bonded to the substrate and (b) a heparin molecule selected from one of the formulae in the claims. The current invention also relates to a method of forming the medical device, which may be useful as heart stent or intravascular stent that is hemocompatible for preventing the formation of blood clots.

Lubricating or blood compatible coatings for medical devices are described.