150 results about "Alkynylation" patented technology

The invention discloses 2-pyridine-oxyl(sulfide) benzoyloxy enoates compound with general formula(I, II); wherein X is H or S; R1 is H, halogen, or 4,6- dimethoxy pyrimidine-2- radicel or one of the following groups; methyls on N-O bonds and double bonds are in maleinoid form or anti form; R2,R3,R4,R6,R7 are selected from H or alkyl from C1-C6; R5 is alkyl from C1-C6, alcoxyl-alkyl from C2-C6, alkenyl from C3-C6 or alkynyl from C3-C6; radicals of R6 and R7 are in maleinoid form or anti form; R8 is alkyl from C1-C6, alkenyl from C3-C6 or alkynyl from C3-C6. The compound (I, II)is of activity in weeding and is safe to crops like soybean, cotton, earthnut, cole, corn, etc.

The invention provides a porous scaffold provided with a surface oriented functionally modified coating and a preparation method of the porous scaffold. The surface of the porous scaffold material structure is coated with a polydopamine coating structure, and a functional component structure layer capable of releasing drug molecules or biomolecules with bioactive function/action in a biological fluid environment is grafted in a modular way to a hydroxyl and/or amino part on the surface of the polydopamine coating structure. During preparation, firstly, the polydopamine coating is deposited on the surface of the porous scaffold; then, hydroxyl groups and/or amino groups in the surface of the scaffold material and corresponding functional components are subjected to azidation or alkynylation respectively; finally, a graft structure layer of the functional components is formed on the surface of the polydopamine coating of the porous scaffold material structure after specific azide-alkynyl modular grafting. The grafting efficiency of the functional components on the surface of the porous scaffold material is high, the grafting structure layer is firmer, the application field of the scaffold material is broadened, more function selections are provided for the scaffold material, and novel means are particularly provided for bone repair, blood vessel therapy, cancer therapy and the like.

The invention relates to a petrol alkanization method for desulfurization. It comprises following steps: preheating raw material, introducing it into reactor, contacting with catalyst at condition of 60- 180 Deg. C, 0.1- 2.0 MPa pressure, and 0.5- 10 h-1 liquid volume hourly space velocity, feeding it intofractionating tower after reaction, cutting into light fraction product and sulfur- enriched heavy fraction at 100- 200 Deg. C; changing raw material into regenerative solvent or gas for catalyst regeneration, recovering regenerated solvent or gas for reuse, and changing into raw oil for reaction. The invention is characterized by simple process, temperate operation condition, high desulfurization rate, little loss of octane number, no obvious change of hydrocarbon component before- and -after reaction, inhibited side- reaction of alkene polymerization and aromatic hydrocarbons alkynylation.

The invention relates to the field of chemistry and preparations, and specifically relates to a gene-therapy drug delivery system and preparation of two click reaction module molecules included in the gene-therapy drug delivery system. A drug liposome of the gene-therapy drug delivery system further contains a modifier and an alkynylation derivative in addition to conventional drug, liposome and cholesterol, wherein the modifier is inserted to a lipid bimolecular layer of the drug liposome by virtue of hydrophobic interaction; the alkynylation derivative is connected to the outermost layer of the drug liposome by virtue of click chemical reaction; the drug is coated with a hydrophilic core of the drug liposome by virtue of electrostatic interaction with the cationic liposome. The delivery system disclosed by the invention has certain targeting performance.

The invention discloses a production method of flumioxazin. The production method comprises the following steps: by using 2,4-difluoronitrobenzene as an initial raw material, sequentially carrying out nitrification to obtain 1,5-difluoro-2,4-dinitrobenzene, and carrying out etherification reaction on the 1,5-difluoro-2,4-dinitrobenzene and butyl hydroxyacetate to obtain butyl 3-fluoro-4,6-dinitrophenoxyacetate; carrying out reduction cyclization with hydrogen to obtain 7-fluoro-6-amino-2H-1,4-benzoxazinyl-3(4H)-one; under alkaline conditions, carrying out alkynylation reaction with propargyl chloride to obtain an intermediate product; and finally, carrying out amidation reaction with 3,4,5,6-tetrahydrophthalic anhydride to obtain the flumioxazin. The production technique of the method has the advantages of short process, mild reaction conditions and cheap and accessible raw materials, and is convenient to operate; and the solvent used in the preparation process is recyclable. The method also has the advantages of high total reaction yield, high product purity, low production cost and low environmental pollution.

The invention discloses a carbazole-based carborane derivative material, and preparation and application methods thereof. The preparation method comprises the following steps: performing alkynylation on 9-(4-bromophenyl)-9-carbazole or 9-(3-bromophenyl)-9-carbazole by a Sonogashira coupling reaction to obtain 9-(4-acetenylphenyl)-9-carbazole or 9-(3-acetenylphenyl)-9-carbazole, and performing a reaction with carborane to synthesize a compound I or compound II. The invention gives out the specific conditions and illustrations on the reaction between the alkynyl derivatives of carbazole and the carborane, and the results show a high yield of the target products. The compounds are simple to prepare, the intermediates are low in cost, and the reaction processes are easy to control; and the products are easy to separate, have the advantages of high yield and high purity, and have potential application values in the aspects of sensors, electroluminescent devices, organic solar cells, organic field-effect transistors and the like. The carborane derivatives can be well applied to electrochemiluminescence (ECL), and can be used as a small-molecule biological fluorescent probe.

The invention relates to mesoporous silicon nano particles having the properties of stimulation response and split-warehouse intelligent drug carrying and release and a preparation method of the mesoporous silicon nano particles. The mesoporous silicon nano particles are characterized in that stimulation response groups are modified on the surface, cyclodextrin modified by alkynylation is used as a nano-valve for realizing split-warehouse medicine carrying, and the particle size is 80-190 nm. The mesoporous silicon nano particles provided by the invention have a carrier system which can store and transport two medicines on the same carrier in a split manner, namely, a split-warehouse double-medicine even multi-medicine co-carrying medicine delivery system, through the effects of the cyclodextrin nano-valve and the response of the stimulation response groups for different extracellular and intracellular stimulation environments, the targeted and intelligent medicine delivery for the tumor cells can be realized.

A disclosed method for producing 2,5-dimethyl-2,5-hexanediol by employing alkynylation condensation process comprises the following steps: (1) taking acetylene and acetone as raw materials to prepared a material solution containing hexynediol; (2) performing separation by employing a potassium hydroxide separation kettle; (3) sending the potassium hydroxide aqueous solution into a nickel alloy continuous evaporator for performing distillation condensation on the potassium hydroxide aqueous solution; (4) sending concentrated potassium hydroxide solution to an inorganic impurity separation apparatus to remove organic impurities; (5) sending the potassium hydroxide aqueous solution subjected to impurity removing to a cast iron evaporator, evaporating water away to form solid potassium hydroxide, then continuously heating to enable solid potassium hydroxide to be in a molten state, and then naturally cooling to perform recrystallization; and (7) cutting recrystallized potassium hydroxide into sheets by a slicer for cycle use as a catalyst raw material. Compared with the prior art, potassium hydroxide is subjected cyclic utilization, so that cost is saved.

The invention discloses cyclic biodegradation aliphatic polyester and a preparation method thereof. The cyclic biodegradation aliphatic polyester is prepared through combination of ring opening polymerization and click chemical reaction. The preparation method comprises the following steps of adopting small-molecule alcohol containing acetylene alkynyl as an initiator to initiate ring opening polymerization of a cyclic ester monomer so as to prepare single-end alkynylation biodegradation aliphatic polyester; enabling the single-end alkynylation biodegradation aliphatic polyester and acid halide and sodium azide to perform reaction sequentially to prepare linear biodegradation aliphatic polyester containing the acetylene alkynyl and azide group; and finally, preparing the cyclic biodegradation aliphatic polyester through the click chemical reaction. The ring size of the cyclic biodegradation aliphatic polyester is controllable, reaction conditions are moderate, and reaction products are pure. In addition, the cyclic biodegradation aliphatic polyester has a topological structure and performance which are different from a structure and the performance of corresponding linear biodegradation aliphatic polyester and can be well applied in the aspects of sustained or controlled release of drug carriers, scaffolds for tissue engineering, blood compatible materials and the like.

The invention discloses a method for preparing a triazolyl bonded cyclodextrin-silica gel chiral stationary phase through a click reaction and application of the method. In the invention, through selective azidation of the 6-hydroxyl of cyclodextrin and alkynylation of silica gel, and by making use of a click reaction with a newly developed catalyst, the triazolyl bonded cyclodextrin-silica gel chiral stationary phase with excellent chemical stability is then prepared, thus enriching the structural design of cyclodextrin. The triazolyl bonded cyclodextrin-silica gel chiral stationary phase ofthe invention shows an excellent chiral separation ability to amino acid, acid and neutral racemic drugs in a liquid chromatogram, thus being expected to be applied in the field of drug chiral separation of various chromatographic techniques as a chiral stationary phase.

A selective hydrogenation process that is particularly effective in selectively hydrogenating alkynl compounds, such as acetylene or methyl acetylene, over alkenyl compounds, such as ethylene, is described. The process utilizes a slurry conversion unit for heat efficiency purposes during the conversion of acetylene into ethylene.

The invention relates to a method for preparing elastomer based on Click reaction. The method for preparing elastomer based on the Click reaction is characterized by including the steps: 1) preparing alkynylation polybutadiene; 2) according to the molar ratio of the total quantity of alkynylation polybutadiene end-C Xi C to N3 in glycidyl azide polymer to cuprous halides being 1:1-4:0.05-0.5, dissolving the alkynylation polybutadiene and the glycidyl azide polymer in tetrahydrofuran, adding glycidyl azide polymer solution into alkynylation polybutadiene solution to obtain mixed solution M, adding the cuprous halides into the mixed solution M under the condition of N2 protection and stirring, keeping the temperature at 0-25 DEG C, and performing reaction away from light for 8-24h to obtainreaction solution N; and 3) performing suction filtration for the reaction solution N, drying filtrate with anhydrous MgSO4, and performing filtration, concentration and solvent volatilization to obtain the elastomer based on the Click reaction. The preparation process is simple, and the elastomer prepared by the method has a good mechanical property.

The invention belongs to a sealant preparation technology and relates to a modified polythioether sealant. The polythioether sealant is characterized by being prepared from, by weight, 100 parts of liquid sulfydryl end-capped polythioether rubber, 1-8 parts of an alkynyl compound, 0.001-1 part of a photo-initiator, 0.1-10 parts of a coupling agent and 10-50 parts of a packing. By the adoption of the polythioether sealant, the problem that a side group is difficult to introduce when an existing photo-curing polythioether sealant is cured is solved.

The invention provides a carbon nitride-carbon-TiO2-selenium nano composite material applied to photocatalytic degradation of pollutants. According to the invention, an azide-modified nano-carbon nitride-nano-titanium dioxide composite material is covalently chelated to the surface of an alkynylation-modified multi-walled carbon nanotube-nano selenium composite material to obtain a carbon nitride-carbon-TiO2-selenium nano composite material. The material can be applied to photocatalytic degradation of pollutants and has excellent photocatalytic degradation properties for the pollutants.

The invention relates to the technical field of organic synthesis, in particular to sulfonamide compounds as well as a preparation method and an application thereof. The preparation method of the sulfonamide compounds comprises the following step: compounds shown as formula (I) are prepared from compounds shown as formula (II) and compounds shown as formula (III) under the action of a catalyst inpresence of an insert solvent, the compounds shown as the formula (I) are brand-new sulfonamide compounds and can be applied to the field of biomedicine. Substrates of the compounds are simple and easily available, for alkynylation reactions of direct carbon-hydrogen bonds of primary sulfonamides or secondary sulfonamides without additional orienting groups, few steps are exerted, operation is simple, the compounds have good atom economy and industrial application value, and the technical problems that the conventional sulfonamide compounds are synthesized through complicated steps and application to industrial production is difficult are solved.

The invention relates to a preparation method of a temperature response type polymer for controlled drug release and genetic vectors. The preparation method comprises the following steps: reacting chitosan oligosaccharide with 4-pentynoic acid when amino acid on chitosan oligosaccharide is protected, so as to obtain alkynylation chitosan oligosaccharide; preparing a macroinitiator by virtue of ring opening polymerization through hydrophobic cyclic ester monomers, introducing temperature-sensitive hydrophilic chains MEO2MA and OEGMA into a macromolecular chain by combining with atom transfer radical polymerization to prepare an amphipathic segmented copolymer, and carrying out azidation on the terminal group of the amphipathic segmented copolymer; and introducing a hydrophilic chitosan oligosaccharide molecular chain into the amphipathic segmented copolymer, so as to prepare the temperature response type polymer for the controlled drug release and the genetic vectors. A polymer material prepared by virtue of the preparation method has temperature responsiveness and biocompatibility and rich amino groups and is capable of carrying exogenous genes; and besides, the amphipathic segmented copolymer can be self-assembled into a micelle in water and has good application prospects in the fields of cancer chemotherapy, gene chemotherapy and the like.

The invention discloses a multi-walled carbon nanotube/ferroferric oxide/nano oxide hybridized wave absorbing material and a preparation method therefor. The preparation method comprises the steps: S1: subjecting multi-walled carbon nanotubes to alkynylation; S2: subjecting ferroferric oxide to alkynylation; S3: subjecting a nano oxide to azidation; and S4: adding the alkynylation modified carbonnanotubes, the alkynylation modified ferroferric oxide and the azidation modified oxide into a catalyst, ligand and organic solvent containing mixed system for a reaction in a nitrogen gas atmosphere,carrying out filtering after the reaction ends up, carrying out washing with deionized water and acetone, and carrying out vacuum drying, thereby obtaining the multi-walled carbon nanotube/ferroferric oxide/nano oxide hybridized wave absorbing material. The material prepared by the method is good in stability and low in density, shows a wave absorbing performance reinforcing effect and has relatively good microwave absorbing performance; and the preparation of the material employs a click chemical method, the operation is easy and feasible, noble-metal catalysis is not used, the economic benefit is good, and thus, the preparation method is applicable to industrial production.

The invention discloses a supported cluster catalyst and preparation and application thereof. The molecular formula of the supported cluster catalyst is Au1Ag24/ZnO or Au12Ag32/ZnO, wherein the molecular formula of a Au1Ag24 cluster is Au1Ag24(SPhMe2)18(PPh4) which is called Au1Ag24 for short; the molecular formula of a Au12Ag32 cluster is Au12Ag32(SPhF2)30(PPh4)4 which is called Au12Ag32 for short. The Au1Ag24/ZnO catalyst and the Au12Ag32/ZnO catalyst can catalyze an alkynylation reaction of trifluoromethyl ketone at high yield, reaction conditions are mild, the catalyst can be recycled at least five times, and the universality of a substrate is high.

The invention discloses a dendrimer with an alkynyl core and an outer amino acid shell, and a Huisgen 1,3-dipolar cycloaddition synthetic method and application thereof. In the preparation process of the dendrimer, 0.5-G, 1.5-G, 2.5-G or 3.5-G dendrimer molecules with an outer azido shell are synthesized; the dendrimer molecules and ascorbic acid/copper sulfate composing a catalytic system are added into alkynylated tertbutyloxycarbonyl-amino acid dissolved in DMF, so that the dendrimer molecules with the outer azido shell and ethynylated amino acids are bonded together through Huisgen 1,3-dipolar cycloaddition; after a reaction at a temperature of 15 to 35 DEG C for 4 to 24 hours, dichloromethane is added to dilute a reaction solution, and then extraction with water is carried out. The invention has the following advantages: reaction specificity is good, reaction efficiency is high, and the outer shell of the dendrimer has a plurality of amino acid ligands, which enables a prepared adsorption material to have better protein separation or blood purification effects compared with common adsorption materials with a space arm as a single active site.

The invention provides a chiral bis-imidazoline pincer rhodium compound and an asymmetric addition reaction method of ethyl trifluoropyruvate with terminal alkyne under the catalysis of the compound. Optically active trifluoromethyl propargyl tertiary alcohol is synthesized in a high enantioselectivity mode. The rhodium compound is simple in preparation, easy to modify in structure and good in stability. During an asymmetric alkynylation reaction for catalyzing the trifluoroacetone acid, the catalyst dosage is few, the reaction temperature is mild and controllable, the application range of a substrate is wide, and the product- optically active trifluoromethyl propargyl tertiary alcohol has a high yield and an enantio-selectivity higher than 95% in most instances.

The invention discloses an arylation or alkynylation modification method of a natural amino acid-oriented polypeptide C (sp3)-H bond. The method comprises the following steps of: in the presence of an oxidant, a catalyst, an additive and a solvent, by taking a compound shown in a formula (III) or a formula (IV) as a modification raw material, respectively performing arylation or alkynylation modification of the C (sp3)-H bond on an alanine side chain in a compound shown in a formula (I) or a formula (II). According to the method disclosed by the invention, a series of fluorescence-labeled alanine-containing polypeptide derivatives, side-chain-modified tyrosine-containing polypeptide derivatives, side-chain-modified phenylalanine-containing polypeptide derivatives and alkynyl-modified alanine-containing polypeptide derivatives can be synthesized. The method disclosed by the invention has the advantages that a guide group does not need to be introduced in advance or subsequently removed, the atom economy and gait economy are high, the conditions are mild, the substrate applicability range is wide, the method is not influenced by amino acid configuration, and the like, and is a polypeptide modification method with excellent popularization prospects.

The invention discloses a chiral cyclopropane alkamine ligand compound, and preparation and application thereof and belongs to the technical field of chiral ligand compounds. The chiral cyclopropane alkamine ligand compound has the structural general formula shown as the specifications. The chiral cyclopropane alkamine ligand compound can be prepared from carane aldehyde acid lactone through four-step reaction. The chiral cyclopropane alkamine ligand compound can be applied to asymmetric addition of alkyne at the tail end to aldehyde. The ligand compound reacts with a metal reagent to preparea zinc, nickel or copper complex catalyst used for catalyzing an asymmetric alkynylation reaction. Compared with the technology reported by documents, the invention has the advantages that: the asymmetric alkynylation reaction is catalyzed by the ligand compound, so the reaction condition is mild, other auxiliary reagents are not required, stereoselectivity is high, and a chiral ligand is derivedfrom cheap pyrethrin.