Porous scaffold provided with surface oriented functionally modified coating and preparation method of porous scaffold

A technology for porous stents and modified coatings, used in coatings, medical science, prostheses, etc.

Inactive Publication Date: 2017-11-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, although CN201210331666.6 proposed using dopamine as a bridge to immobilize functional molecules on the surface of biomedical materials, it proposed to use chemical reactions to graft

Method used

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  • Porous scaffold provided with surface oriented functionally modified coating and preparation method of porous scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Porous titanium alloy scaffold material with surface grafted chondroitin sulfate coating

[0044] The first step, the preparation of porous titanium alloy

[0045] The porous titanium alloy is prepared by 3D printing, with a length and width of 10mm and a height of 5mm. Ultrasonic cleaning with absolute ethanol for 10 minutes, then ultrasonic cleaning with distilled water for 5 minutes, and drying.

[0046] The second step, polydopamine coating preparation

[0047] The porous titanium alloy was soaked in a dopamine hydrochloride solution with a concentration of 2mg / ml, the concentration of Tris in the solution was 10mM, the pH value was 8.5, the soaking time was 48 hours, and the reaction temperature was 37°C. After the coating was deposited, it was ultrasonically cleaned with distilled water and absolute ethanol for 5 minutes, respectively, and dried. A substrate material with a structure of scaffold-polydopamine was formed. Repeat twice to form a double...

Embodiment 2

[0054] Example 2: Porous titanium alloy scaffold material with surface grafted chondroitin sulfate coating

[0055] The first step, the preparation of porous titanium alloy

[0056] The porous titanium alloy is prepared by 3D printing, with a length and width of 10mm and a height of 5mm. Ultrasonic cleaning with absolute ethanol for 10 minutes, then ultrasonic cleaning with distilled water for 5 minutes, and drying.

[0057] The second step, polydopamine coating preparation

[0058] The porous titanium alloy was soaked in a dopamine hydrochloride solution with a concentration of 2mg / ml, the concentration of Tris in the solution was 10mM, the pH value was 8.5, the soaking time was 48 hours, and the reaction temperature was 37°C. After the coating was deposited, it was ultrasonically cleaned with distilled water and absolute ethanol for 5 minutes, respectively, and dried. A substrate material with a structure of scaffold-polydopamine was formed. Repeat three times to form th...

Embodiment 3

[0067] Example 3: Porous titanium alloy stent material coated with terminal alkyne antibacterial drug terbinacol on the surface

[0068] The first step, the preparation of porous titanium alloy

[0069] The porous titanium alloy is prepared by 3D printing, with a length and width of 10mm and a height of 5mm. Ultrasonic cleaning with absolute ethanol for 10 minutes, then ultrasonic cleaning with distilled water for 5 minutes, and drying.

[0070] The second step, polydopamine coating preparation

[0071] The porous titanium alloy was soaked in a dopamine hydrochloride solution with a concentration of 2mg / ml, the concentration of Tris in the solution was 10mM, the pH value was 8.5, the soaking time was 48 hours, and the reaction temperature was 37°C. After the coating was deposited, it was ultrasonically cleaned with distilled water and absolute ethanol for 5 minutes, respectively, and dried. Repeat three times to form a three-layer polydopamine-coated base material.

[0072...

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Abstract

The invention provides a porous scaffold provided with a surface oriented functionally modified coating and a preparation method of the porous scaffold. The surface of the porous scaffold material structure is coated with a polydopamine coating structure, and a functional component structure layer capable of releasing drug molecules or biomolecules with bioactive function/action in a biological fluid environment is grafted in a modular way to a hydroxyl and/or amino part on the surface of the polydopamine coating structure. During preparation, firstly, the polydopamine coating is deposited on the surface of the porous scaffold; then, hydroxyl groups and/or amino groups in the surface of the scaffold material and corresponding functional components are subjected to azidation or alkynylation respectively; finally, a graft structure layer of the functional components is formed on the surface of the polydopamine coating of the porous scaffold material structure after specific azide-alkynyl modular grafting. The grafting efficiency of the functional components on the surface of the porous scaffold material is high, the grafting structure layer is firmer, the application field of the scaffold material is broadened, more function selections are provided for the scaffold material, and novel means are particularly provided for bone repair, blood vessel therapy, cancer therapy and the like.

Description

technical field [0001] The invention relates to a scaffold structure in which a functional component modification structure layer including medicine is grafted on the surface of a porous scaffold structure and a preparation method thereof. Background technique [0002] Porous scaffolds have important applications in the field of biomedical engineering, especially in tissue engineering and bone regenerative medicine. The conventional preparation of porous scaffold materials mainly includes foaming method, electrospinning, mold porous sintering method, 3D additive printing, etc. Taking bone repair twice as an example, regardless of the use of inorganic, organic, metal, or composite materials, even if bioactive or drug components are mixed in the matrix, the surface structure of the porous scaffold obtained by these preparation methods is dense. , it is difficult to effectively achieve the designed slow-release or controlled-release effect during implantation, and cannot provi...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/18A61L27/06A61L27/50A61L27/54A61L27/56A61L27/58
Inventor 左奕胡釜李玉宝陈杰邹琴李吉东
Owner SICHUAN UNIV
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