114 results about "Azide" patented technology

Methods described herein use benzene sulfonyl azide molecules as scavengers of sulfur species, including H2S, mercaptans, or both in industrial processes such as hydrocarbon production.

The application discloses a kind of copper azide content trace detection method, the detection method includes: detecting copper azide content: taking the sample to be measured and inorganic acid mixed dissolution, then sequentially adding NaOH solution, buffer solution and copper nitrate solution, using ultraviolet visible spectrophotometer to measure absorbance and calculate corresponding azide radical concentration, determine the content of copper azide and cuprous azide in the sample to be measured by azide radical and copper azide content relationship model;Detect copper azide and cuprous azide: on the basis of measuring copper azide content, determine the content of copper azide and cuprous azide in the sample to be measured by azide radical and copper azide / cuprous azide content relationship model.The copper azide content trace detection method needs simple device of the application, low requirement to equipment, does not need organic solvent or color developing agent, and environmental pollution is small, and sub-milligram level copper azide used in MEMS fuze can be detected.

Methods described herein use benzene sulfonyl azide molecules as scavengers of sulfur species, including H2S, mercaptans, or both in industrial processes such as hydrocarbon production.

The present invention belongs to the technical field of organic chemical synthesis and discloses a method for preparing asymmetric ketone compounds. This invention, for the first time, achieves the denitrogenation and decarboxylation coupling of vinyl azide with alkyl carboxylates / Katritz salts in the absence of a photocatalyst, filling a gap in the prior art. The method of the present invention features mild process conditions, a short flow, simple steps, and a wide range of substrate applicability, meeting industrial production requirements. Research has found that the product yield can reach as high as 88%, and the resulting ketone compounds have broad application prospects in organic synthesis and drug development. Therefore, the present invention has significant application value.

In a first aspect, the present invention is directed to a magnetic particle having a saturation magnetization ≥ 15 Am2 / kg and having at least one azide group –N=N'-N- bonded to a polymer matrix of the magnetic particle. A second aspect of the invention relates to a process for preparing a magnetic particle, which comprises at least one magnetic core (M), a polymer matrix (P) comprising a crosslinked polymer at least partially surrounding the magnetic core (M), the polymer matrix (P) comprising on its surface at least a functional group reactive towards amine groups and / or hydroxyl groups. In a third aspect, the invention is directed to the magnetic particle obtained or obtainable from the process of the second aspect. A fourth aspect is related to a process for preparing a magnetic particle having a saturation magnetization ≥ 15 Am2 / kg of the first aspect, and a fifth aspect relates to the magnetic particle obtained or obtainable from the process of the fourth aspect. A sixth aspect is directed to the use of the magnetic particle having a saturation magnetization ≥ 15 Am2 / kg of the first aspect or of the fourth aspect for qualitative and / or quantitative determination of at least one analyte in a fluid or in a gas, and a seventh aspect relates to a method for determining at least one analyte in a fluid using said magnetic particle having a saturation magnetization ≥ 15 Am2 / kg.

The present invention discloses an atomically polymerized nitrogen material and a preparation method thereof, belonging to the technical field of energetic materials, and solves one of the following problems: (1) the relatively harsh conditions for synthesizing cg-PN; and (2) the low content of cg-PN prepared by the prior art. The preparation method of the present invention obtains the atomically polymerized nitrogen material by directly quenching an azide compound from a high temperature to room temperature under high pressure. The cg-PN prepared by the preparation method of the present invention has high yield and can be recovered under conventional conditions, and has potential application value in the field of energetic materials.

Disclosed are a quantum dot-containing material, a method of preparing the quantum dot-containing material, a cross-linked material of the quantum dot-containing material, and a method of preparing the same, and a light-emitting device comprising the quantum dot-containing material. The quantum dot-containing material may include a quantum dot and an organic group chemically bound to a surface of the quantum dot, the organic group may include an azide group and a charge transport group, and the charge transport group may not be an unsubstituted benzene group.

The application provides a method for continuously preparing iodine azide and application thereof, and comprises the following steps: sending an azide reagent and a quaternary ammonium salt phase transfer reagent into a continuous flow reactor to obtain a mixture A, then reacting the mixture A with an iodine reagent entering the continuous flow reactor to obtain iodine azide, and continuously discharging the iodine azide from the continuous flow reactor during the reaction to obtain the iodine azide. The application utilizes the continuous flow reactor to quickly and efficiently prepare the explosive iodine azide. Compared with the existing sodium azide / ICl technology, the application greatly solves the explosion risk caused by the storage and transfer of a large amount of sodium azide, and greatly improves the safety.

Provided are an azide-based compound, a composition including the azide-based compound, an organic light-emitting device including the azide-based compound, and a method of manufacturing the organic light-emitting device. The organic light emitting device includes: a first electrode; a second electrode facing the first electrode; an organic layer disposed between the first electrode and the second electrode and including an emission layer; and an azide compound represented by Formula 1.

A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable bicyclic prostaglandin; L is a linker group; and at least one co-monomer of Formula III J-(Y1-A)n, J represents a linking functional group, n is 2 to 8 preferably 3 to 8; Y1 comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to C10 alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.

The present invention discloses a method for preparing polymerized nitrogen and polymerized nitrogen, belonging to the technical field of energetic materials, and solves one of the following problems: (1) the relatively harsh conditions for synthesizing cg-PN; and (2) the low content of cg-PN prepared by existing techniques. The preparation method of the present invention obtains polymerized nitrogen by quenching an azide compound and carbon nanotubes from a high temperature to room temperature under high pressure. The cg-PN prepared by the preparation method of the present invention has a high yield and can be recovered under conventional conditions, and has potential application value in the field of energetic materials.

The application discloses a new method for synthesizing 3-acyl imidazo[1,5-a]pyridine compounds. The method comprises the following steps: adding 2-pyridyl-p-methanequinone (2-Py-p-QMs), terminal alkyne and p-toluenesulfonyl azide (TsN3), catalyst CuI, organic solvent and alkali into a reaction container under the condition of RT and O2 atmosphere, stirring the reaction for 4 hours, and then separating and purifying 3-acyl imidazo[1,5-a]pyridine compounds after the reaction is completed. The method expands the structure range of 3-acyl imidazo[1,5-a]pyridine products, and more compounds with rich structures can be obtained. Compared with the previous method for synthesizing the target product, the method is efficient, the reaction reagent is non-corrosive, the method design is novel, the raw material is cheap, the operation method is simple, and the product can be directly obtained under mild conditions.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The invention discloses an azide modified platinum radiotherapy sensitizer as well as a preparation method and application thereof. The azide modified platinum radiotherapy sensitizer is an azide modified platinum complex, comprises a cis platinum complex and a trans platinum complex, and is characterized in that the structure of the azide modified platinum radiotherapy sensitizer is shown in the specification; in the formula I, R1 is cyclohexylamine or 2-methylpyridine; in the formula II, R2 is ammonia molecules or pyridine. The azide modified platinum radiotherapy sensitizer can generate a platinum-nitrogen-bin free radical under the irradiation of X rays, and by utilizing a nitrogen transfer reaction in organic chemistry, the platinum-nitrogen-bin free radical generated after the compound is irradiated by rays can be covalently coupled with some DNA (Deoxyribose Nucleic Acid) or protein, so that the sensitivity of the radiotherapy sensitizer is improved. The radiotherapy sensitization effect in tumor radiotherapy is achieved by directly damaging DNA and hindering DNA repair.

The present invention belongs to the field of organic chemistry technology, and in particular to a highly active heterometallic CuIn‑MOF catalyst and a preparation method thereof and a method and application of its catalytic amino synthesis of organic azides, and more particularly to a method for preparing a heterometallic CuIn‑MOF catalyst material based on 3,5-bis(4-carboxylphenyl)pyridine ligands and its catalytic amino compound to prepare an azide compound. The inventive method is as follows: using CuIn‑MOF as a reaction catalyst, an amino compound is added to a reactor, reacted at a specific temperature, and after the reaction is completed, the product is separated and purified to obtain the corresponding organic azide compound. The present invention has the characteristics of simple operation, mild reaction conditions, short reaction time, high reaction purity, and being applicable to highly active amino compounds, is suitable for industrial production, and provides ideas and methods for subsequent highly active natural amino compounds to participate in click chemistry.

Two rhodamine reversible fluorescent sensor derivatives, L1 and L2, bearing 2-methoxy-1-naphthaldehyde and 5-bromo-3-methoxy salicylaldehyde units were synthesized using microwave-assisted organic synthesis and used for selective and sensitive reversible sequential fluorescence detection of aluminum ion (Al3+) and azide (N3−) in aqueous acetonitrile solution via the fluorescence spectral changes. Stoichiometry and binding mechanisms for both sensors are well characterized and established by the respective spectroscopic techniques. L1 and L2 sensors are useful for the analysis of Al3+ and N3− in environmental samples and biological studies

The invention discloses a synthesis method of 5-substituted-3, 4-dihydroisoquinoline-1 (2H)-ketone, which comprises the following steps: a) carrying out condensation reaction on a compound as shown in a formula 2 to obtain a compound as shown in a formula 3; carrying out rearrangement reaction on the compound shown in the formula 3 to obtain a compound shown in a formula 4; and carrying out ring closing on the compound shown in the formula 4 under an acid catalysis condition to obtain a compound shown in a formula 5. The synthesis method provided by the invention avoids the following problems in a known synthesis strategy: raw materials are expensive, and the cost of the whole process is difficult to control; or a highly toxic and easy-to-explode azidation reagent is used, and large-scale production is difficult to realize through an azidation intermediate state with poor stability; therefore, the synthetic method disclosed by the invention is efficient, mild and green, and is more suitable for large-scale production and commercial production.

The present invention relates to a fluorinated azide derivative, its preparation method, and application. The fluorinated azide derivative is represented by the following general structural formula I or II: wherein R1, R2, and R3 are each selected from any one or more of phenyl, substituted aryl, alkyl, heterocyclic, or hydrogen. The fluorinated azide derivative is obtained by reacting a fluoroalkyl iodide derivative, an azidating agent, a catalyst, a free radical initiator, and an organic solvent. Compared with existing technologies, the present invention has the advantages of high efficiency, i.e., short reaction time, high yield (over 90%), and mild reaction conditions.

A method of attaching an azide moiety to a biomolecule. The method comprises contacting a biomolecule in a solution with an azide and a copper, for a time wherein at least one azide moiety is covalently bonded to the biomolecule to yield an azidylated biomolecule. The copper is copper (I), and can be generated from copper (II) by a reductant. The solution further comprises a copper ligand for reducing degradation of the biomolecule. The azilylated biomolecule can be attached to a reagent comprising an alkyne via a copper-catalyzed azide-alkyne cycloaddition (“CuAAC”) reaction or a strain-promoted alkyne-azide cycloaddition (“SPAAC”) reaction.

The present invention discloses a preparation method of structurally controllable polyionic liquids, belonging to the technical field of polymer materials. This method first synthesizes a series of structurally controllable cationic sequence monodisperse polymers with alkynyl end groups, and then conducts a copper-catalyzed azide-alkyne click reaction with polyepichlorohydrin modified with azide groups to complete polymer modification and realize the synthesis of polyionic liquids. The preparation method provided by the present invention has mild reaction conditions, high yield, simple post-treatment, and precisely controllable cationic side chain structure, and has potential and wide application value in the fields of biomedicine, functional materials, etc.

The application provides a PCBM, a preparation method and application thereof, and a device for preparing the PCBM, and belongs to the field of photovoltaic material design, manufacturing and application. The preparation method comprises the following steps: synthesizing an azide compound solution; providing a fullerene solution; adding the azide compound solution into the fullerene solution; reacting the azide compound and the fullerene to obtain a reaction product; and post-treating the reaction product to obtain the PCBM. The method can improve the yield of the PCBM, and reduce the residual amount of the fullerene and the amount of by-products.

This invention discloses an internal standard-assisted petal-shaped SERS nanoprobe, its preparation method, and its applications. The internal standard-assisted petal-shaped SERS nanoprobe of this invention is a core-molecule-shell structure gold nanoprobe consisting of a gold nanosphere core, an internal standard modifying molecule, a petal-shaped gold nanoshell, and a recognition molecule, 4-nitrobenzenethiophenol. The internal standard modifying molecule is a Raman signal molecule with nitrile, alkyne, or azide functional groups. This invention uses a Raman signal molecule as an internal standard modifying molecule to modify the gold nanosphere core. The corrected working curve exhibits good reproducibility and small error, improving the reliability of the detection results. Growing a petal-shaped gold nanoshell on the molecular layer of the internal standard modifying molecule enhances the SERS activity both inside and outside the SERS substrate, and the petal-shaped shell increases the surface area of ​​the SERS substrate. Furthermore, the recognition molecule of this invention enables ratiometric Raman detection of hydrogen sulfide, effectively reducing background signal interference and improving detection sensitivity.

The invention provides a deuterated alkenyl furan compound and a preparation method thereof. The deuterated olefin furan compound comprises a furan ring, a deuterated alkenyl group (the deuteration rate is 94%) and a carbonyl group, can be derived and converted in multiple directions, and has structural novelty. The preparation method comprises the following steps: reacting an eneyne ketone compound with deuterated alkenyl azide (the deuteration rate is 94%) under the catalysis of zinc to generate the deuterated alkenyl furan compound. The synthetic method has the advantages of simple and efficient preparation process, no heavy metal residue risk, no need of acid-base assistance, no equipment corrosion hidden danger, 100% deuteration conversion, high deuteration rate (94%) of the product, and potential industrial application value. # imgabs0 #

The invention provides a preparation method of ((1R, 3S)-3-hydroxycyclopentyl) tert-butyl carbamate, which comprises the following steps: (1) mixing (R)-3-oxocyclopentane carboxylic acid with alkali, diphenyl azide phosphate and tert-butyl alcohol for reaction to obtain an intermediate; and (2) mixing the intermediate with a chiral catalyst and borane for reaction to obtain ((1R, 3S)-3-hydroxycyclopentyl) tert-butyl carbamate. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple process operation, safe and controllable production and high optical purity of the target product, and can meet the requirements of industrial production.

This invention discloses a silver-catalyzed method for synthesizing benzo[d]isothiazol-3(2H)-one via sulfur-nitrogen atom exchange, belonging to the field of organic synthesis technology. The method uses benzodisulfonic acid ketone compounds and azide compounds as raw materials, and, under the action of a silver catalyst, inorganic base, and organophosphorus compounds, with acetonitrile as the solvent, undergoes a heated reaction followed by separation and purification to obtain the target product. This invention achieves molecular skeleton editing of benzodisulfonic acid ketone through S-N atom exchange. The reaction conditions are mild, require no inert gas protection, are simple to operate, exhibit good functional group tolerance, and achieve high yields. It can be applied to the later-stage transformation of active molecules and drug molecules, providing a new route for the efficient synthesis of benzo[d]isothiazol-3(2H)-one compounds.

The application discloses a synthesis method of 1,4-disubstituted 1,2,3-triazole and belongs to the technical field of organic synthesis. In an air atmosphere, an alkyne compound and an azide compound are subjected to a mechanical activation induced cycloaddition reaction in the presence of a copper catalyst, a 4-mercapto-1,2,3-triazole ligand and a promoter, and 1,4-disubstituted 1,2,3-triazole is obtained. The method has the following advantages: (1) toxic and volatile organic solvents can be avoided; (2) inert gas atmosphere can be avoided; (3) the reaction time is short; (4) the catalyst loading is low; (5) the yield is high; and (6) the functional group tolerance range is wide.

This invention belongs to the field of medicinal chemistry and pharmaceutical technology, specifically relating to a method for preparing a rufiamide impurity reference standard. The method includes the following steps: (1) mixing o-fluorobenzyl alcohol, 1H-1,2,3-triazol-4-nitrile, photocatalytic reaction reagent, triphenylphosphine, and solvent 1, and reacting to obtain 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-nitrile; (2) mixing 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-nitrile, carbonate, hydrogen peroxide, and solvent 2, and reacting to obtain 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-formamide. This invention is simple to operate, has milder reaction conditions, and does not involve the use or generation of azides; the synthesis method is green and novel, and can rapidly and efficiently prepare 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-formamide.

The present invention provides a differential modification method and use for a polypeptide. The differential modification method for a polypeptide comprises: step S1. providing an aromatic aldehyde and a polypeptide, and mixing the aromatic aldehyde and the polypeptide in a reaction solvent, so that an aldehyde group of the aromatic aldehyde reacts with an N-terminus of the polypeptide to generate a dihydroimidazolone intermediate reaction solution; and step S2. adding an alkaline substance and fluorosulfonyl azide to the dihydroimidazolone intermediate reaction solution for an azide reaction to obtain a modified polypeptide reaction solution. By means of the reactivity difference of polypeptide terminal groups, the present application achieves differential modifications of the N-terminus and C-terminus of the polypeptide separately by means of a one-pot two-step method in a similar pH environment, especially the modification of amino groups at two termini of a polypeptide having lysine at the C-terminus with different groups separately. The specificity is improved, the reaction conditions are simple and mild, the route is short, the operation is convenient, large-scale production is easily implemented, and the cost is saved.

The invention discloses a method for synthesizing a benzyl azide compound in a tubular reactor, and belongs to the technical field of azide compounds. According to the technical scheme, the method comprises the following steps: 1) dissolving sodium azide in a solvent I to prepare a sodium azide solution; dissolving benzyl halide in a solvent II to prepare a benzyl halide solution; (2) continuously pumping the sodium azide solution and the benzyl halide solution into a tubular reactor respectively, and reacting under a control condition to generate a reaction solution; according to the method, benzyl halide / substituted benzyl halide and sodium azide are used as raw materials, the characteristics of efficient mass transfer and heat transfer of the tubular reactor are brought into full play, and the reaction efficiency and the product yield are greatly improved.

The invention belongs to the technical field of organic chemistry, and particularly relates to a dehydroabietic acid 1, 2, 3-triazole derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting dehydroabietic acid in a first organic solvent under the action of a reducing agent to obtain a compound 2 with reduced carboxyl; reacting the compound 2 with p-toluenesulfonyl chloride under the action of an alkali solution to obtain a hydroxyl-protected compound 3; in a second organic solvent, reacting the compound 3 with sodium azide under a high-temperature condition to obtain an azide compound 4; and reacting the compound 4 with a copper salt and an alkyne compound in a polar solvent of alkali to obtain a target compound. The dehydroabietic acid derivative with high biological activity is synthesized, raw materials are cheap and easy to obtain, reaction conditions are mild, aftertreatment is simple, the yield is high, a virulent solvent is not used in the synthesis process, the green chemical requirement is met, high pressure or a special catalyst is not needed, and large-scale production can be achieved in conventional equipment.