63 results about "Azide" patented technology

The application discloses a kind of copper azide content trace detection method, the detection method includes: detecting copper azide content: taking the sample to be measured and inorganic acid mixed dissolution, then sequentially adding NaOH solution, buffer solution and copper nitrate solution, using ultraviolet visible spectrophotometer to measure absorbance and calculate corresponding azide radical concentration, determine the content of copper azide and cuprous azide in the sample to be measured by azide radical and copper azide content relationship model;Detect copper azide and cuprous azide: on the basis of measuring copper azide content, determine the content of copper azide and cuprous azide in the sample to be measured by azide radical and copper azide / cuprous azide content relationship model.The copper azide content trace detection method needs simple device of the application, low requirement to equipment, does not need organic solvent or color developing agent, and environmental pollution is small, and sub-milligram level copper azide used in MEMS fuze can be detected.

In a first aspect, the present invention is directed to a magnetic particle having a saturation magnetization ≥ 15 Am2 / kg and having at least one azide group –N=N'-N- bonded to a polymer matrix of the magnetic particle. A second aspect of the invention relates to a process for preparing a magnetic particle, which comprises at least one magnetic core (M), a polymer matrix (P) comprising a crosslinked polymer at least partially surrounding the magnetic core (M), the polymer matrix (P) comprising on its surface at least a functional group reactive towards amine groups and / or hydroxyl groups. In a third aspect, the invention is directed to the magnetic particle obtained or obtainable from the process of the second aspect. A fourth aspect is related to a process for preparing a magnetic particle having a saturation magnetization ≥ 15 Am2 / kg of the first aspect, and a fifth aspect relates to the magnetic particle obtained or obtainable from the process of the fourth aspect. A sixth aspect is directed to the use of the magnetic particle having a saturation magnetization ≥ 15 Am2 / kg of the first aspect or of the fourth aspect for qualitative and / or quantitative determination of at least one analyte in a fluid or in a gas, and a seventh aspect relates to a method for determining at least one analyte in a fluid using said magnetic particle having a saturation magnetization ≥ 15 Am2 / kg.

Disclosed are a quantum dot-containing material, a method of preparing the quantum dot-containing material, a cross-linked material of the quantum dot-containing material, and a method of preparing the same, and a light-emitting device comprising the quantum dot-containing material. The quantum dot-containing material may include a quantum dot and an organic group chemically bound to a surface of the quantum dot, the organic group may include an azide group and a charge transport group, and the charge transport group may not be an unsubstituted benzene group.

The application provides a method for continuously preparing iodine azide and application thereof, and comprises the following steps: sending an azide reagent and a quaternary ammonium salt phase transfer reagent into a continuous flow reactor to obtain a mixture A, then reacting the mixture A with an iodine reagent entering the continuous flow reactor to obtain iodine azide, and continuously discharging the iodine azide from the continuous flow reactor during the reaction to obtain the iodine azide. The application utilizes the continuous flow reactor to quickly and efficiently prepare the explosive iodine azide. Compared with the existing sodium azide / ICl technology, the application greatly solves the explosion risk caused by the storage and transfer of a large amount of sodium azide, and greatly improves the safety.

A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable bicyclic prostaglandin; L is a linker group; and at least one co-monomer of Formula III J-(Y1-A)n, J represents a linking functional group, n is 2 to 8 preferably 3 to 8; Y1 comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to C10 alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.

The application discloses a new method for synthesizing 3-acyl imidazo[1,5-a]pyridine compounds. The method comprises the following steps: adding 2-pyridyl-p-methanequinone (2-Py-p-QMs), terminal alkyne and p-toluenesulfonyl azide (TsN3), catalyst CuI, organic solvent and alkali into a reaction container under the condition of RT and O2 atmosphere, stirring the reaction for 4 hours, and then separating and purifying 3-acyl imidazo[1,5-a]pyridine compounds after the reaction is completed. The method expands the structure range of 3-acyl imidazo[1,5-a]pyridine products, and more compounds with rich structures can be obtained. Compared with the previous method for synthesizing the target product, the method is efficient, the reaction reagent is non-corrosive, the method design is novel, the raw material is cheap, the operation method is simple, and the product can be directly obtained under mild conditions.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The invention discloses an azide modified platinum radiotherapy sensitizer as well as a preparation method and application thereof. The azide modified platinum radiotherapy sensitizer is an azide modified platinum complex, comprises a cis platinum complex and a trans platinum complex, and is characterized in that the structure of the azide modified platinum radiotherapy sensitizer is shown in the specification; in the formula I, R1 is cyclohexylamine or 2-methylpyridine; in the formula II, R2 is ammonia molecules or pyridine. The azide modified platinum radiotherapy sensitizer can generate a platinum-nitrogen-bin free radical under the irradiation of X rays, and by utilizing a nitrogen transfer reaction in organic chemistry, the platinum-nitrogen-bin free radical generated after the compound is irradiated by rays can be covalently coupled with some DNA (Deoxyribose Nucleic Acid) or protein, so that the sensitivity of the radiotherapy sensitizer is improved. The radiotherapy sensitization effect in tumor radiotherapy is achieved by directly damaging DNA and hindering DNA repair.

The invention discloses a synthesis method of 5-substituted-3, 4-dihydroisoquinoline-1 (2H)-ketone, which comprises the following steps: a) carrying out condensation reaction on a compound as shown in a formula 2 to obtain a compound as shown in a formula 3; carrying out rearrangement reaction on the compound shown in the formula 3 to obtain a compound shown in a formula 4; and carrying out ring closing on the compound shown in the formula 4 under an acid catalysis condition to obtain a compound shown in a formula 5. The synthesis method provided by the invention avoids the following problems in a known synthesis strategy: raw materials are expensive, and the cost of the whole process is difficult to control; or a highly toxic and easy-to-explode azidation reagent is used, and large-scale production is difficult to realize through an azidation intermediate state with poor stability; therefore, the synthetic method disclosed by the invention is efficient, mild and green, and is more suitable for large-scale production and commercial production.

A method of attaching an azide moiety to a biomolecule. The method comprises contacting a biomolecule in a solution with an azide and a copper, for a time wherein at least one azide moiety is covalently bonded to the biomolecule to yield an azidylated biomolecule. The copper is copper (I), and can be generated from copper (II) by a reductant. The solution further comprises a copper ligand for reducing degradation of the biomolecule. The azilylated biomolecule can be attached to a reagent comprising an alkyne via a copper-catalyzed azide-alkyne cycloaddition (“CuAAC”) reaction or a strain-promoted alkyne-azide cycloaddition (“SPAAC”) reaction.

This invention discloses an internal standard-assisted petal-shaped SERS nanoprobe, its preparation method, and its applications. The internal standard-assisted petal-shaped SERS nanoprobe of this invention is a core-molecule-shell structure gold nanoprobe consisting of a gold nanosphere core, an internal standard modifying molecule, a petal-shaped gold nanoshell, and a recognition molecule, 4-nitrobenzenethiophenol. The internal standard modifying molecule is a Raman signal molecule with nitrile, alkyne, or azide functional groups. This invention uses a Raman signal molecule as an internal standard modifying molecule to modify the gold nanosphere core. The corrected working curve exhibits good reproducibility and small error, improving the reliability of the detection results. Growing a petal-shaped gold nanoshell on the molecular layer of the internal standard modifying molecule enhances the SERS activity both inside and outside the SERS substrate, and the petal-shaped shell increases the surface area of ​​the SERS substrate. Furthermore, the recognition molecule of this invention enables ratiometric Raman detection of hydrogen sulfide, effectively reducing background signal interference and improving detection sensitivity.

The invention provides a preparation method of ((1R, 3S)-3-hydroxycyclopentyl) tert-butyl carbamate, which comprises the following steps: (1) mixing (R)-3-oxocyclopentane carboxylic acid with alkali, diphenyl azide phosphate and tert-butyl alcohol for reaction to obtain an intermediate; and (2) mixing the intermediate with a chiral catalyst and borane for reaction to obtain ((1R, 3S)-3-hydroxycyclopentyl) tert-butyl carbamate. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, simple process operation, safe and controllable production and high optical purity of the target product, and can meet the requirements of industrial production.

This invention discloses a silver-catalyzed method for synthesizing benzo[d]isothiazol-3(2H)-one via sulfur-nitrogen atom exchange, belonging to the field of organic synthesis technology. The method uses benzodisulfonic acid ketone compounds and azide compounds as raw materials, and, under the action of a silver catalyst, inorganic base, and organophosphorus compounds, with acetonitrile as the solvent, undergoes a heated reaction followed by separation and purification to obtain the target product. This invention achieves molecular skeleton editing of benzodisulfonic acid ketone through S-N atom exchange. The reaction conditions are mild, require no inert gas protection, are simple to operate, exhibit good functional group tolerance, and achieve high yields. It can be applied to the later-stage transformation of active molecules and drug molecules, providing a new route for the efficient synthesis of benzo[d]isothiazol-3(2H)-one compounds.

The application discloses a synthesis method of 1,4-disubstituted 1,2,3-triazole and belongs to the technical field of organic synthesis. In an air atmosphere, an alkyne compound and an azide compound are subjected to a mechanical activation induced cycloaddition reaction in the presence of a copper catalyst, a 4-mercapto-1,2,3-triazole ligand and a promoter, and 1,4-disubstituted 1,2,3-triazole is obtained. The method has the following advantages: (1) toxic and volatile organic solvents can be avoided; (2) inert gas atmosphere can be avoided; (3) the reaction time is short; (4) the catalyst loading is low; (5) the yield is high; and (6) the functional group tolerance range is wide.

This invention belongs to the field of medicinal chemistry and pharmaceutical technology, specifically relating to a method for preparing a rufiamide impurity reference standard. The method includes the following steps: (1) mixing o-fluorobenzyl alcohol, 1H-1,2,3-triazol-4-nitrile, photocatalytic reaction reagent, triphenylphosphine, and solvent 1, and reacting to obtain 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-nitrile; (2) mixing 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-nitrile, carbonate, hydrogen peroxide, and solvent 2, and reacting to obtain 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-formamide. This invention is simple to operate, has milder reaction conditions, and does not involve the use or generation of azides; the synthesis method is green and novel, and can rapidly and efficiently prepare 1-(2-fluorobenzyl)-1H-1,2,3-triazol-4-formamide.

The present invention provides a differential modification method and use for a polypeptide. The differential modification method for a polypeptide comprises: step S1. providing an aromatic aldehyde and a polypeptide, and mixing the aromatic aldehyde and the polypeptide in a reaction solvent, so that an aldehyde group of the aromatic aldehyde reacts with an N-terminus of the polypeptide to generate a dihydroimidazolone intermediate reaction solution; and step S2. adding an alkaline substance and fluorosulfonyl azide to the dihydroimidazolone intermediate reaction solution for an azide reaction to obtain a modified polypeptide reaction solution. By means of the reactivity difference of polypeptide terminal groups, the present application achieves differential modifications of the N-terminus and C-terminus of the polypeptide separately by means of a one-pot two-step method in a similar pH environment, especially the modification of amino groups at two termini of a polypeptide having lysine at the C-terminus with different groups separately. The specificity is improved, the reaction conditions are simple and mild, the route is short, the operation is convenient, large-scale production is easily implemented, and the cost is saved.

The invention discloses a method for synthesizing a benzyl azide compound in a tubular reactor, and belongs to the technical field of azide compounds. According to the technical scheme, the method comprises the following steps: 1) dissolving sodium azide in a solvent I to prepare a sodium azide solution; dissolving benzyl halide in a solvent II to prepare a benzyl halide solution; (2) continuously pumping the sodium azide solution and the benzyl halide solution into a tubular reactor respectively, and reacting under a control condition to generate a reaction solution; according to the method, benzyl halide / substituted benzyl halide and sodium azide are used as raw materials, the characteristics of efficient mass transfer and heat transfer of the tubular reactor are brought into full play, and the reaction efficiency and the product yield are greatly improved.

The invention discloses a method for synthesizing a sulfonate compound based on a flowing photochemical technology, which comprises the following steps: (1) carrying out azidation reaction on a phenylacetate compound and p-toluenesulfonyl azide under the action of alkali to obtain an alpha-diazophenylacetate compound; and (2) respectively dissolving a sulfonic acid compound and the alpha-diazophenylacetate compound obtained in the step (1) in an organic solvent to form solutions, then continuously inputting the solutions into a microchannel reactor, carrying out an illumination reaction under an illumination condition, and after the reaction is finished, carrying out post-treatment to obtain the sulfonate compound. The preparation method can realize continuous reaction and is high in yield.

The invention relates to a thermal insulation material and a finished product crystallization reaction kettle applied to intermediate synthesis, and belongs to the technical field of thermal insulation materials. The preparation method comprises the following steps: carrying out ring opening on vinyl ethylene oxide through diluted hydrochloric acid to obtain 4-chloro-1-butene-3-alcohol, reacting with paratoluensulfonyl chloride to obtain a sulfonate derivative, reacting with magnesium chips to generate a Grignard reagent, and reacting with tetraethoxysilane to obtain sulfonate silane; then, sulfonate silane and sodium azide are subjected to an azido reaction to obtain azido silane, and azido silane and triphenylphosphine are subjected to a reaction and purification to obtain an amino co-precursor; mixing and reacting the amino co-precursor with tetraethoxysilane, absolute ethyl alcohol and deionized water, and aging and drying to obtain hydrophobic amino silicon dioxide aerogel; and finally, taking polyether polyol as a base material, adding the hydrophobic amino silicon dioxide aerogel, and reacting with diphenylmethane diisocyanate to obtain the thermal insulation material.

The invention discloses a triazene bridged azole-based crystal as well as a preparation method and application thereof in energetic materials, and belongs to the field of energetic materials. The chemical formula of the crystal is Co < 2 > C < 8 > H < 16 > N < 28 > O < 2 > or Co < 2 > C < 10 > H < 20 > N < 28 > O < 2 >. The crystal has good stability and safety. After the material is physically mixed with commercial primary explosive lead azide, the laser initiation threshold value is reduced by 1500 times compared with that of single lead azide, and RDX can be successfully detonated; compared with a standard commercial laser ignition agent B / KNOs, the laser initiation threshold value is reduced by 250 times, and meanwhile the defects that the laser ignition agent B / KNOs is only a combustion reaction and the explosion performance is reduced are overcome. The method has great application value in the field of high-performance laser response energetic materials.

The application discloses a kind of organic silicon macromolecular azide coupling agent and preparation method thereof.The organic silicon macromolecular azide coupling agent includes three main chain structures: linear single chain structure, ladder double chain structure and three chain structure.The organic silicon azide coupling agent of the application is easy to break and recombine under the condition of ultraviolet light irradiation, thereby realizing the crosslinking of material.

The disclosure herein provides, in example embodiments, methods and systems for labeling biomolecules with CuAAC using a copper-catalyzed azide-alkyne cycloaddition (CuAAC)-accelerating ligand.

This invention discloses a magnetic microsphere modified with a high-density carboxyl polymer brush and its preparation method. The method includes the following steps: using ATRP technology, the polymerization of GMA is precisely initiated by an azide-based initiator to synthesize PGMA with controllable molecular weight and narrow distribution; the epoxy groups of PGMA undergo a ring-opening reaction with ethylenediamine, followed by reaction with bromoacetic acid to obtain a functionalized polymer brush; utilizing the high efficiency and specificity of azide-alkynyl click chemistry, the carboxylated polymer brush is covalently grafted onto the surface of the magnetic microspheres. This invention achieves precise design of the polymer brush molecular structure and successfully prepares magnetic microspheres with significantly increased carboxyl content, up to a maximum content of 1.495 mmol·g. ‑1 The polymer brush modification strategy of this invention significantly improves the functional group density on the surface of microspheres and their binding ability with biomolecules. The resulting magnetic microspheres have strong magnetic responsiveness and are not easily leaked. They can be used as high-performance platform materials and are widely used in fields such as bioseparation, diagnostic analysis and catalysis.

This invention belongs to the field of organic chemical synthesis, specifically relating to a method for stabilizing tetrazolium using a metal-organic cage. The method includes the following steps: placing a pentagonal tritetrahedral metal-organic cage in acetonitrile solvent to form a mixture; then placing the mixture in a sealed container (such as a hydrothermal reactor or a hard glass tube) and heating it at 100°C for 72 hours under solvothermal conditions, followed by slow cooling to obtain the tetrazolium compound. The preparation method provided by this invention is simple and easy to control. It utilizes the azide groups in the metal-organic cage structure to synthesize tetrazolium in situ. Simultaneously, the metal-organic cage can stabilize energetic tetrazolium molecules, avoiding the risk of explosion due to collisions during transportation and storage. This has significant implications for expanding the synthesis and storage of tetrazolium and similar energetic molecules.

The present application relates to the technical field of oilfield chemical technology, and is a water-based annulus protection fluid and a preparation method thereof.The former raw materials, calculated according to mass percentage, comprise 0.1% to 2% acid gas corrosion inhibitor, 0.1% to 2% polycyclic azide structure sulfur removal agent, 0.1% to 2% polymeric guanidine bactericide, 0.1% to 5% oxygen scavenger, and 0.1% to 2% pH regulator, with the rest being water.The required amount of acid gas corrosion inhibitor, polycyclic azide structure sulfur removal agent, polymeric guanidine bactericide, oxygen scavenger and pH regulator are added to water, and after mixing and stirring, the water-based annulus protection fluid is obtained.The present application has good corrosion inhibition effect under simulated working conditions, with a corrosion inhibition rate of less than 0.05 mm / a, which is much lower than the corresponding industry standard.The scale inhibition rate and bactericidal rate meet the industry standard, and the present application has good protection function for the inner wall of the casing and the outer wall of the oil and gas pipeline in the annular space under acidic environment, which not only prolongs the service life, but also guarantees the safety production of oilfields.

The application provides a sitafloxacin intermediate and an enzymatic preparation method and application thereof, and belongs to the technical field of organic synthesis and enzyme catalysis. The sitafloxacin intermediate compound 3 is a key chiral intermediate for preparing sitafloxacin. The preparation method comprises the following steps: (1) reacting compound 1 with an azide reagent to obtain compound 2; (2) catalyzing and reacting compound 2 by using a transaminase to obtain compound 3. The preparation method for preparing compound TM by using compound 3 comprises the following steps: (A) reducing compound 3 by using a reducing reagent and carrying out amine-ester exchange to obtain compound 4; (B) reacting compound 4 with a Boc reagent to obtain compound 5; (C) reducing compound 5 to obtain product TM. The process is simple in operation, conventional reaction equipment is used, raw materials are cheap and easy to obtain, the yield is high, the process introduces the biological enzyme catalysis technology, high stereoselectivity product is obtained, and the cost is greatly reduced.

Methods described herein use benzene sulfonyl azide molecules as scavengers of sulfur species, including H2S, mercaptans, or both in industrial processes such as hydrocarbon production.

The application discloses a kind of double-1,2,3-triazole-bisalkyl alcohol derivatives and preparation method and application in nuclide extraction, belong to the field of chemical synthesis and applied chemistry field, the present application with double end chain alkynol-containing nitrogen hetero six-membered ring and azido group-containing alcohol as raw material, with active copper as catalyst, azide-alkyne ring addition reaction is carried out in solvent, and double-1,2,3-triazole-bisalkyl alcohol derivatives are creatively generated, and it is found through experiment that the above-mentioned double-1,2,3-triazole-bisalkyl alcohol derivatives have good effect in nuclide extraction, and can effectively separate radioactive element uranium in seawater.

The present invention relates to a compound of formula (I), wherein R1 is selected from the group consisting of B1 and Y1, R2 is selected from the group consisting of B2 and Y2, R3 is selected from the group consisting of B3 and Y3, and R4 is selected from the group consisting of B4 and Y4; and B1 and B3 are independently selected from the group consisting of fluoro, chloro and bromo; B2 and B4 are independently selected from the group consisting of hydrogen and fluoro; when R1 is Y1 and R2 is Y2, Y1 is selected from the group consisting of oxygen, sulfur and selenium, and Y2 is -CH2CH2- or -CH=CH-, and together with Y1 forms a five-membered ring system; when R3 is Y3 and R4 is Y4, Y3 is selected from the group consisting of oxygen, sulfur and selenium, and Y4 is -CH2CH2- or -CH=CH-, and together with Y3 forms a five-membered ring system; and X is D-(L p -A) m H 1-m The formula is selected from the group consisting of S and O, where D is selected from the group consisting of S and O, p is 1, m is 1, L is a linker group, and A is a reactive group. JPEG2026521068000033.jpg60166