150 results about "Azide" patented technology

The invention provides a medical hydrophilic coating and a preparation method and application thereof.The coating comprises a substrate layer and a functional layer, the substrate layer is arranged on the surface of a medical base material, the functional layer is arranged on the surface of the side, away from the medical base material, of the substrate layer, and the substrate layer comprises a substrate modification material containing a first reactive functional group; the functional layer comprises a phosphorylcholine compound containing a second reactive functional group; the substrate layer and the functional layer are connected through a chemical bond formed by the first reactive functional group and the second reactive functional group; the substrate modification material contains a third reactive functional group, and the substrate layer is connected with the medical base material through a chemical bond formed by the third reactive functional group and hydroxyl or amino on the surface of the medical base material; when the first reactive functional group is an azide group, the second reactive functional group is an alkynyl group; or when the first reactive functional group is the alkynyl group, the second reactive functional group is the azide group. Chemical bonds are formed through azido and alkynyl, multiple chemical reactions are not needed, and the uniformity of the coating is improved.

The invention provides an ultrasonic activated azido precursor, a prodrug and application. The precursor and an active drug react and are bonded to obtain the azido prodrug; the bonding group of the active medicine is amino, hydroxyl or sulfydryl; a bonding group of the ultrasonic activated azido precursor is an ester group. Novel ultrasonic activatable groups, namely p-azidobenzyloxycarbonyl and derivatives thereof, are adopted, hydrogen atoms on a benzene ring are substituted to different degrees, the reducing capacity of a precursor can be remarkably improved, azide is effectively reduced into amino through ultrasonic stimulation under the action of TBR and NADH, and then a self-elimination reaction is induced to release active drugs. The structure has the advantages that different types of active drugs (active pharmacodynamic groups can be amino, hydroxyl and sulfydryl) can be bonded through 4-nitrophenyl carbonate, high-selectivity reduction is performed under the triple action of ultrasound, TBR and NADH, active raw drugs are released according to needs, and toxicity reduction and synergism are achieved.

The invention discloses a method for photocatalytic synthesis of N, O-spiroketal amine derivatives, and belongs to the technical field of organic synthesis. Aiming at the problems of harsh conditions, small substrate range and the like of the existing synthesis method, the invention provides the method for photocatalytic synthesis of the N, O-spiroketal amine derivative, and the method comprises the following steps: mixing a 1-alkenyloxy ring compound, a 1-azido vinyl ring compound, a photocatalyst, alkali and an organic solvent, and carrying out photocatalytic reaction to obtain the N, O-spiroketal amine derivative. The 1, 1, 2-trifunctional reaction of the N-alkenyloxy onium salt and the vinyl azide is successfully realized through a strategy of efficiently constructing an N, O-spiroketal amine skeleton under the catalysis of photooxidation reduction, and the method is simple and convenient to operate and high in yield. The method is mild in reaction condition, stable in process condition, high in product yield, easy in product purification, wide in substrate range, good in functional group tolerance, low in production cost and suitable for large-scale production.

The present invention provides a novel strain-promoted azide alkynes cycloaddition reaction (strain-promoted azide alkynes cycloaddition reaction (SPAAC)), and a preparation method of the strain-promoted azide alkynes cycloaddition reaction (SPAAC), and the strain-promoted azide alkynes cycloaddition reaction (SPAAC) can be used for preparing the strain-promoted azide alkynes cycloaddition reaction. The present invention provides a novel cycloalkyne derivative having a spiro ring as a cycloalkyne derivative that can be used in SPAAC. Also provided is a method for producing a conjugate of a functional molecule using the cycloalkyne derivative.

Methods described herein use benzene sulfonyl azide molecules as scavengers of sulfur species, including H2S, mercaptans, or both in industrial processes such as hydrocarbon production.

The application discloses a kind of copper azide content trace detection method, the detection method includes: detecting copper azide content: taking the sample to be measured and inorganic acid mixed dissolution, then sequentially adding NaOH solution, buffer solution and copper nitrate solution, using ultraviolet visible spectrophotometer to measure absorbance and calculate corresponding azide radical concentration, determine the content of copper azide and cuprous azide in the sample to be measured by azide radical and copper azide content relationship model;Detect copper azide and cuprous azide: on the basis of measuring copper azide content, determine the content of copper azide and cuprous azide in the sample to be measured by azide radical and copper azide / cuprous azide content relationship model.The copper azide content trace detection method needs simple device of the application, low requirement to equipment, does not need organic solvent or color developing agent, and environmental pollution is small, and sub-milligram level copper azide used in MEMS fuze can be detected.

Methods described herein use benzene sulfonyl azide molecules as scavengers of sulfur species, including H2S, mercaptans, or both in industrial processes such as hydrocarbon production.

The invention provides a triazole-containing compound as well as a synthesis method and application thereof, and belongs to the field of pesticides. The method comprises the following steps: taking heterocyclic molecules with carboxyl functional groups as raw materials, carrying out amidation reaction on the heterocyclic molecules and aminoacetylene to generate an intermediate as shown in a formula (I), and reacting the intermediate (I) with an azide to obtain the amide-containing triazole compound as shown in a formula (II), substituted benzaldehyde, sodium azide and 2-(benzenesulfonyl) acetonitrile are used as raw materials to react to generate the cyano-containing triazole compound as shown in a formula (III). The method disclosed by the invention is simple to operate, relatively mild in condition and high in functional group tolerance. The prepared intermediate and the final product have certain insecticidal and bactericidal activity, and have potential application prospects.

The present invention belongs to the technical field of organic chemical synthesis and discloses a method for preparing asymmetric ketone compounds. This invention, for the first time, achieves the denitrogenation and decarboxylation coupling of vinyl azide with alkyl carboxylates / Katritz salts in the absence of a photocatalyst, filling a gap in the prior art. The method of the present invention features mild process conditions, a short flow, simple steps, and a wide range of substrate applicability, meeting industrial production requirements. Research has found that the product yield can reach as high as 88%, and the resulting ketone compounds have broad application prospects in organic synthesis and drug development. Therefore, the present invention has significant application value.

In a first aspect, the present invention is directed to a magnetic particle having a saturation magnetization ≥ 15 Am2 / kg and having at least one azide group –N=N'-N- bonded to a polymer matrix of the magnetic particle. A second aspect of the invention relates to a process for preparing a magnetic particle, which comprises at least one magnetic core (M), a polymer matrix (P) comprising a crosslinked polymer at least partially surrounding the magnetic core (M), the polymer matrix (P) comprising on its surface at least a functional group reactive towards amine groups and / or hydroxyl groups. In a third aspect, the invention is directed to the magnetic particle obtained or obtainable from the process of the second aspect. A fourth aspect is related to a process for preparing a magnetic particle having a saturation magnetization ≥ 15 Am2 / kg of the first aspect, and a fifth aspect relates to the magnetic particle obtained or obtainable from the process of the fourth aspect. A sixth aspect is directed to the use of the magnetic particle having a saturation magnetization ≥ 15 Am2 / kg of the first aspect or of the fourth aspect for qualitative and / or quantitative determination of at least one analyte in a fluid or in a gas, and a seventh aspect relates to a method for determining at least one analyte in a fluid using said magnetic particle having a saturation magnetization ≥ 15 Am2 / kg.

The present invention discloses an atomically polymerized nitrogen material and a preparation method thereof, belonging to the technical field of energetic materials, and solves one of the following problems: (1) the relatively harsh conditions for synthesizing cg-PN; and (2) the low content of cg-PN prepared by the prior art. The preparation method of the present invention obtains the atomically polymerized nitrogen material by directly quenching an azide compound from a high temperature to room temperature under high pressure. The cg-PN prepared by the preparation method of the present invention has high yield and can be recovered under conventional conditions, and has potential application value in the field of energetic materials.

Disclosed are a quantum dot-containing material, a method of preparing the quantum dot-containing material, a cross-linked material of the quantum dot-containing material, and a method of preparing the same, and a light-emitting device comprising the quantum dot-containing material. The quantum dot-containing material may include a quantum dot and an organic group chemically bound to a surface of the quantum dot, the organic group may include an azide group and a charge transport group, and the charge transport group may not be an unsubstituted benzene group.

The application provides a method for continuously preparing iodine azide and application thereof, and comprises the following steps: sending an azide reagent and a quaternary ammonium salt phase transfer reagent into a continuous flow reactor to obtain a mixture A, then reacting the mixture A with an iodine reagent entering the continuous flow reactor to obtain iodine azide, and continuously discharging the iodine azide from the continuous flow reactor during the reaction to obtain the iodine azide. The application utilizes the continuous flow reactor to quickly and efficiently prepare the explosive iodine azide. Compared with the existing sodium azide / ICl technology, the application greatly solves the explosion risk caused by the storage and transfer of a large amount of sodium azide, and greatly improves the safety.

Provided are an azide-based compound, a composition including the azide-based compound, an organic light-emitting device including the azide-based compound, and a method of manufacturing the organic light-emitting device. The organic light emitting device includes: a first electrode; a second electrode facing the first electrode; an organic layer disposed between the first electrode and the second electrode and including an emission layer; and an azide compound represented by Formula 1.

A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable bicyclic prostaglandin; L is a linker group; and at least one co-monomer of Formula III J-(Y1-A)n, J represents a linking functional group, n is 2 to 8 preferably 3 to 8; Y1 comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to C10 alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.

The present application belongs to the field of organic synthesis technology, and in particular to a method for synthesizing alkaloids by catalysis of alkaloids and ferric porphyrin. The preparation method comprises the steps of: using ferric porphyrin as a catalyst, converting azide compound A into product compound B through ferric nitrogen amination reaction; the chemical structure formula of azide compound A is #imgabs0# the chemical formula of product compound B is #imgabs1#X is selected from C-R5, CO, O, S, SO, SO2, Se or P-R6; n1, n2 are respectively independently positive integers of 1 to 4, and when n1, n2 are greater than 1, multiple R2 are the same or different, and multiple R4 are the same or different; R1, R2, R3, R4, R5 exist independently or at least form a polycyclic ring. Many biologically active alkaloids and their derivatives can be prepared by this method, the synthesis process is simple, the ferric porphyrin catalyst is a cheap metal catalyst, which reduces the synthesis cost and is conducive to industrial production and application.

The present invention discloses a method for preparing polymerized nitrogen and polymerized nitrogen, belonging to the technical field of energetic materials, and solves one of the following problems: (1) the relatively harsh conditions for synthesizing cg-PN; and (2) the low content of cg-PN prepared by existing techniques. The preparation method of the present invention obtains polymerized nitrogen by quenching an azide compound and carbon nanotubes from a high temperature to room temperature under high pressure. The cg-PN prepared by the preparation method of the present invention has a high yield and can be recovered under conventional conditions, and has potential application value in the field of energetic materials.

The application discloses a new method for synthesizing 3-acyl imidazo[1,5-a]pyridine compounds. The method comprises the following steps: adding 2-pyridyl-p-methanequinone (2-Py-p-QMs), terminal alkyne and p-toluenesulfonyl azide (TsN3), catalyst CuI, organic solvent and alkali into a reaction container under the condition of RT and O2 atmosphere, stirring the reaction for 4 hours, and then separating and purifying 3-acyl imidazo[1,5-a]pyridine compounds after the reaction is completed. The method expands the structure range of 3-acyl imidazo[1,5-a]pyridine products, and more compounds with rich structures can be obtained. Compared with the previous method for synthesizing the target product, the method is efficient, the reaction reagent is non-corrosive, the method design is novel, the raw material is cheap, the operation method is simple, and the product can be directly obtained under mild conditions.

The invention discloses an atomic polymerization nitrogen material and a preparation method thereof, belongs to the technical field of energetic materials, and solves one of the following problems: (1) conditions for synthesizing cg-PN are relatively harsh; and (2) the content of cg-PN prepared by the prior art is low. According to the preparation method disclosed by the invention, the azide is directly quenched from high temperature to room temperature under high pressure to obtain the atom polymerization nitrogen material. The cg-PN prepared by the preparation method disclosed by the invention is high in yield, can be recycled under conventional conditions, and has potential application value in the field of energetic materials.

The present invention discloses a boric acid-functionalized covalent organic framework microcapsule adsorbent and its preparation method and application. First, TAPB-BTCA-BPTA COFs are synthesized, and Pickering water-in-oil single emulsions are obtained by using TAPB-BTCA-BPTA COFs as stabilizing particles. Using the Pickering water-in-oil emulsion droplets as carriers, a COF shell layer is formed by an autonomous growth method at the emulsion droplet interface for subsequent introduction of azidoboric acid. Finally, the boric acid-functionalized covalent organic framework microcapsule BA-TAPB-BTCA-BPTA MC is prepared by grafting azidoboric acid N3-PBA through the "azide-alkyne" click reaction. It has excellent mechanical strength and stability and is used for the specific adsorption and separation research of active ingredients.

The invention relates to a polymer for treating a surface, which polymer comprises: n reactive intermediate precursor groups, wherein n is an integer equal to or greater than 3; and m groups which comprise an atom-transfer radical polymerization (ATRP) initiator, wherein m is an integer equal to or greater than 3, wherein the reactive intermediate precursor groups are selected from carbene precursor groups and nitrene precursor groups, wherein the carbene precursor groups are selected from hydrazone groups of formula (A), diazo groups of formula (B) and diazirine groups of formula (C), and the nitrene precursor groups are azide groups of formula (D), wherein R1 is H or -S(O)2R2, and R2 is an unsubstituted or substituted C1-6 alkyl group or an unsubstituted or substituted aryl group. The invention also relates to a process for producing a treated substrate, which treated substrate has a surface suitable for surface -initiated atom-transfer radical polymerization (SIATRP). The invention also relates to a treated substrate having a surface suitable for SIATRP, and to treated substrates obtainable by the aforementioned process of the invention. The invention also relates to a treated substrate which comprises: a substrate, a reacted polymer disposed on a surface of the substrate, and a further polymer, grown by SIATRP, bonded to the reacted polymer.

The invention discloses an azide modified platinum radiotherapy sensitizer as well as a preparation method and application thereof. The azide modified platinum radiotherapy sensitizer is an azide modified platinum complex, comprises a cis platinum complex and a trans platinum complex, and is characterized in that the structure of the azide modified platinum radiotherapy sensitizer is shown in the specification; in the formula I, R1 is cyclohexylamine or 2-methylpyridine; in the formula II, R2 is ammonia molecules or pyridine. The azide modified platinum radiotherapy sensitizer can generate a platinum-nitrogen-bin free radical under the irradiation of X rays, and by utilizing a nitrogen transfer reaction in organic chemistry, the platinum-nitrogen-bin free radical generated after the compound is irradiated by rays can be covalently coupled with some DNA (Deoxyribose Nucleic Acid) or protein, so that the sensitivity of the radiotherapy sensitizer is improved. The radiotherapy sensitization effect in tumor radiotherapy is achieved by directly damaging DNA and hindering DNA repair.

The present invention discloses an azide-containing asymmetric ortho-diamine compound and its synthesis method, belonging to the field of organic synthesis. Under the action of adding a hypervalent iodine reagent and in an inert gas atmosphere, a three-component reaction of an olefin, a diaryl ketimine compound and an azide reagent is realized, completing the asymmetric diamination reaction of the olefin and simultaneously constructing a technical solution for two C-N bonds. The reaction conditions are extremely mild, the olefin raw materials are widely sourced and inexpensive and easily available, the experimental operation is simple and safe, and it is easy to apply and expand; commercially available benzophenone imine and azide reagent are used; the azide group and the imine can be further converted into primary amine compounds, which have very good application prospects in the synthesis of natural products and drug molecules, saving a large amount of research time and shortening the production cycle, and having a foreseeable market commercialization prospect.

The present invention belongs to the field of organic chemistry technology, and in particular to a highly active heterometallic CuIn‑MOF catalyst and a preparation method thereof and a method and application of its catalytic amino synthesis of organic azides, and more particularly to a method for preparing a heterometallic CuIn‑MOF catalyst material based on 3,5-bis(4-carboxylphenyl)pyridine ligands and its catalytic amino compound to prepare an azide compound. The inventive method is as follows: using CuIn‑MOF as a reaction catalyst, an amino compound is added to a reactor, reacted at a specific temperature, and after the reaction is completed, the product is separated and purified to obtain the corresponding organic azide compound. The present invention has the characteristics of simple operation, mild reaction conditions, short reaction time, high reaction purity, and being applicable to highly active amino compounds, is suitable for industrial production, and provides ideas and methods for subsequent highly active natural amino compounds to participate in click chemistry.

Two rhodamine reversible fluorescent sensor derivatives, L1 and L2, bearing 2-methoxy-1-naphthaldehyde and 5-bromo-3-methoxy salicylaldehyde units were synthesized using microwave-assisted organic synthesis and used for selective and sensitive reversible sequential fluorescence detection of aluminum ion (Al3+) and azide (N3−) in aqueous acetonitrile solution via the fluorescence spectral changes. Stoichiometry and binding mechanisms for both sensors are well characterized and established by the respective spectroscopic techniques. L1 and L2 sensors are useful for the analysis of Al3+ and N3− in environmental samples and biological studies

The invention discloses a synthesis method of 5-substituted-3, 4-dihydroisoquinoline-1 (2H)-ketone, which comprises the following steps: a) carrying out condensation reaction on a compound as shown in a formula 2 to obtain a compound as shown in a formula 3; carrying out rearrangement reaction on the compound shown in the formula 3 to obtain a compound shown in a formula 4; and carrying out ring closing on the compound shown in the formula 4 under an acid catalysis condition to obtain a compound shown in a formula 5. The synthesis method provided by the invention avoids the following problems in a known synthesis strategy: raw materials are expensive, and the cost of the whole process is difficult to control; or a highly toxic and easy-to-explode azidation reagent is used, and large-scale production is difficult to realize through an azidation intermediate state with poor stability; therefore, the synthetic method disclosed by the invention is efficient, mild and green, and is more suitable for large-scale production and commercial production.

The present invention relates to a fluorinated azide derivative, its preparation method, and application. The fluorinated azide derivative is represented by the following general structural formula I or II: wherein R1, R2, and R3 are each selected from any one or more of phenyl, substituted aryl, alkyl, heterocyclic, or hydrogen. The fluorinated azide derivative is obtained by reacting a fluoroalkyl iodide derivative, an azidating agent, a catalyst, a free radical initiator, and an organic solvent. Compared with existing technologies, the present invention has the advantages of high efficiency, i.e., short reaction time, high yield (over 90%), and mild reaction conditions.

A method of attaching an azide moiety to a biomolecule. The method comprises contacting a biomolecule in a solution with an azide and a copper, for a time wherein at least one azide moiety is covalently bonded to the biomolecule to yield an azidylated biomolecule. The copper is copper (I), and can be generated from copper (II) by a reductant. The solution further comprises a copper ligand for reducing degradation of the biomolecule. The azilylated biomolecule can be attached to a reagent comprising an alkyne via a copper-catalyzed azide-alkyne cycloaddition (“CuAAC”) reaction or a strain-promoted alkyne-azide cycloaddition (“SPAAC”) reaction.

The present invention discloses a preparation method of structurally controllable polyionic liquids, belonging to the technical field of polymer materials. This method first synthesizes a series of structurally controllable cationic sequence monodisperse polymers with alkynyl end groups, and then conducts a copper-catalyzed azide-alkyne click reaction with polyepichlorohydrin modified with azide groups to complete polymer modification and realize the synthesis of polyionic liquids. The preparation method provided by the present invention has mild reaction conditions, high yield, simple post-treatment, and precisely controllable cationic side chain structure, and has potential and wide application value in the fields of biomedicine, functional materials, etc.

The application provides a PCBM, a preparation method and application thereof, and a device for preparing the PCBM, and belongs to the field of photovoltaic material design, manufacturing and application. The preparation method comprises the following steps: synthesizing an azide compound solution; providing a fullerene solution; adding the azide compound solution into the fullerene solution; reacting the azide compound and the fullerene to obtain a reaction product; and post-treating the reaction product to obtain the PCBM. The method can improve the yield of the PCBM, and reduce the residual amount of the fullerene and the amount of by-products.