851 results about "Cornea" patented technology

The invention relates to recombinant III-type humanized collagen and application of a composition containing the same to eyes. The invention provides an application of recombinant III type humanized collagen in preparation of a product for preventing and / or treating eye inflammation, a composition containing the recombinant III type humanized collagen, and an application of the composition in preparation of a product for preventing and / or treating eye inflammation and / or eye dryness. The recombinant III-type humanized collagen and the composition containing the recombinant III-type humanized collagen can obviously promote updating and repairing of corneal epithelial cells, and meanwhile, can inhibit release of inflammatory mediators, enhance eye tissue barriers, enhance tear film stability and relieve eye inflammation and eye dryness.

The invention provides a subjective optometry prediction method combining wavefront aberration and optical signals. According to the method, eyeball wavefront aberration data are measured through a wavefront sensor, cornea, crystal and retina biological parameters are obtained by combining multi-view-field scanning of a galvanometer system, and after high-credibility data points are screened, a gradient refractive index eyeball three-dimensional model is constructed by adopting an NURBS algorithm; using finite element analysis to optimize cornea stress distribution, iteratively correcting the model through a deformation energy function, and dynamically compensating eyeball motion errors based on eye movement tracking data; and generating a multi-field-angle visual chart image through ray tracing simulation, and predicting a subjective optometry result in combination with an image quality evaluation algorithm. According to the method, high-precision modeling, dynamic error suppression and intelligent simulation technologies are fused, the optometry prediction accuracy, the personalized adaptation degree and the dynamic scene adaptability are remarkably improved, and an efficient and reliable solution is provided for refraction correction.

Shape-stabilized collagen scaffolds and methods of obtaining such scaffolds are disclosed. Stroma can be harvested, for example, from human or porcine corneal stroma and shaped during excision or in a separate step after excision. Following shaping (and preferably decellularization), the excised stroma portion is subject to pressure, force or vacuum to reduce fluid content and then irradiated or otherwise treated to induce crosslinking of collagen chains or fibrils. In one embodiment, the scaffold can be compacted by removing some or all of the water from the scaffold, and rehydrating the scaffold in a controlled manner (e.g., in a mold or other confining space) such that the scaffold takes a desired compacted shape; and then crosslinking at least a portion of the scaffold to mechanically strengthen it and inhibit subsequent swelling. Various sources of energy can be employed to induce crosslinking of collagen including, for example, ultraviolet (UV) radiation. The scaffolds can also be selectively densified or patterned. The invention is particularly useful in forming stable lenticules of enhanced stiffness and sufficient optical clarity for intracorneal implantation in additive ocular surgery.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a grasping body having a longitudinal axis, and a piercing member coupled to the grasping body, including an elongate body and a beveled piercing tip including a long side and a short side, wherein the piercing member includes a proximal segment, a distal segment, and an aperture nested between the proximal segment and the distal segment, wherein the short side and the aperture are coaxially disposed along a central longitudinal axis of the piercing member, and wherein the piercing member is configured to reciprocate along the longitudinal axis relative to the grasping body.

The embodiment of the invention discloses a visual field tracking method and device, and the method achieves the differential weight fusion of an image through a first infrared image set, greatly reduces the influence of a tear film, a lens scratch, a cosmetic contact lens line and other interference factors, improves the recognition accuracy of a cornea reflection point, and improves the sight tracking precision. The combined methods of FFT confidence analysis, RANSAC algorithm verification, Kalman filtering, median filtering and the like are adopted, interference of pseudo spots and dynamic noise is effectively reduced, and the stability and reliability of cornea reflection point detection are remarkably improved. The self-adaptive enhancement technology and the ROI accurate extraction method are adopted, so that the method can better adapt to eye feature differences of different users and various complex actual environments and illumination conditions, and the universality of the visual field tracking device is enhanced. Differential fusion, feature recognition, confidence verification and filtering processing are automatically carried out in the whole process, and manual intervention is not needed.

An arrangement for tracking a position of an individual's eye comprises: (a) a frame mountable on a head of an individual; (b) at least one visually transparent element mounted within the frame in a the field of view of an eye of the individual; (c) at least one infrared light source configured for emitting an infrared light beam; (d) an image sensor configured for capturing images of the eye; (e) a processing unit configured for controlling the infrared light source and the image sensor and detecting a pupil position and a corneal reflection within images captured the at least image sensor. The transparent element comprises a spectrally-selective layer configured for reflecting the infrared beam. The visually transparent element is configured for selectively directing the infrared beam onto the eye and directing an infrared radiation reflected from a pupil and cornea of the eye to the image sensor.

This invention discloses a 2D gaze point estimation method based on the pupil-corneal reflection vector method. It utilizes the star ray method for pupil center localization and adds a classification pupil detection mechanism for error correction. Corneal feature extraction is performed to obtain the center coordinates of the corneal reflected light spot. Step 4: Establish a gaze mapping model, and assign the detected pupil-corneal reflection vector V(V) to each frame of the image. x V y The gaze coordinates G(G) mapped onto the screen x G y This invention enables 2D gaze point estimation based on the pupil-corneal reflection vector method. Compared with existing technologies, this invention can improve the accuracy of 2D gaze point estimation.

The invention relates to the field of surgical robots, and particularly discloses an intraoperative risk assessment system for a cataract surgical robot, comprising: a patient biomechanical monitoring unit for collecting a contact force between an instrument and an eye tissue, and calculating an anterior chamber equivalent pressure value according to an axial force component of the contact force and a contact area between the instrument and a cornea; the patient optical imaging monitoring unit is used for collecting microstructure images of the cornea and the lens capsule and quantifying the energy release density of ultrasonic emulsification; the robot motion parameter monitoring unit is used for collecting joint motion resistance, instrument tail end three-dimensional coordinates, motion speed and attitude angle of the robot; the multi-mode joint reasoning unit is used for identifying a high-risk operation state when the contact force is higher than a first preset value and the energy release density is higher than a second preset value; by adopting the technical scheme of the invention, multi-dimensional real-time monitoring can be realized, and a dynamic risk prediction model can be established by fusing heterogeneous data through an intelligent algorithm.

The utility model relates to the technical field of contact lenses, and particularly discloses a comfortable sclera lens which comprises an outer surface, the inner side of the outer surface is connected with an optical area, the periphery of the optical area is sequentially provided with a first transition area, a second transition area and a landing area, the first transition area and the second transition area are connected with each other, and the optical area is not in contact with the cornea. A plurality of liquid guide grooves are evenly formed in the inner side of the landing area at intervals, the inner ends of the liquid guide grooves penetrate through the first transition area and the second transition area and extend to the edge of the optical area, through holes are formed in the positions, close to the edge of the landing area, of the bottoms of the liquid guide grooves, and the through holes penetrate through the landing area. According to the sclera lens, the plurality of liquid guide grooves are formed, tear exchange between the sclera lens and the periphery of the eyes can be achieved after the sclera lens is worn, the situation that the eyes are dry after the sclera lens is worn for a long time is relieved, meanwhile, the through holes are formed in the inner sides of the liquid guide grooves, the tear exchange efficiency can be further improved through the through holes, the oxygen permeation rate can be improved, and the comfort degree is high when the sclera lens is worn.

The invention provides a machine learning and deep learning combined calibration-free eye movement tracking system and method, and the system comprises the following modules: a pre-calibration module which is used for collecting a near-to-eye image of the eyes of a user through a near-to-eye camera and an infrared light source, extracting pupil center coordinates and cornea reflection point coordinates, and outputting the pupil center coordinates and the cornea reflection point coordinates; calculating a personalized kappa angle of the user based on the extracted pupil center coordinates and cornea reflection point coordinates; the decision maker module adopts an AdaBoost ensemble learning algorithm, classifies the users according to the kappa angle obtained through calculation, and outputs a corresponding weight combination; and the deep learning module is used for receiving the output weight combination and the real-time near-eye image, and predicting the coordinates of the fixation point of the user through a convolutional neural network and a residual connection structure. According to the invention, the application flexibility and user friendliness of the eye movement tracking technology are greatly enhanced while the precision is guaranteed.

The present application relates to the field of smart wearable devices. Provided are a light source position calibration method, a device and a storage medium. The method comprises: using an image collection apparatus to collect user eye images; extracting from the eye images corresponding light spot two-dimensional coordinates and light spot three-dimensional coordinates of light spots formed by a light source, and, on the basis of the light spot two-dimensional coordinates, determining corresponding light source two-dimensional coordinates of the light source; and, on the basis of the light source two-dimensional coordinates, the light spot three-dimensional coordinates and preset coordinate parameters, determining corresponding light source three-dimensional coordinates of the light source, so as to calibrate the light source position of the light source in a smart wearable device on the basis of the light source three-dimensional coordinates. The present application calculates a position of a light source device on the basis of light spots formed by the light source in cornea areas of eye images, thus reducing the complexity of light source position calibration.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

The utility model discloses a light feeding instrument to solve the problem that retina light damage is possibly caused after long-term use in the prior art, and meanwhile, the treatment effect is also improved. Compared with the prior art in which only parameters such as red light source power and emergent light beam size are concerned, the utility model focuses on the important index of irradiance (power density), emergent light is a collimated Gaussian beam and the optical characteristics of eyes (a human eye refraction system is equivalent to a convex lens with a focal length of 17.2 mm). An optical component diffuser is additionally arranged at the position close to the cornea of a user, so that a collimated Gaussian beam is converted into diffused light to enter the eyes of the user, and diffused light spots are formed on the retina, the treatment area is sufficient, energy distribution is uniform, it is ensured that the irradiance is at the expected safety magnitude, and meanwhile the actual treatment effect is ensured.

Apparatus and methods are described for performing a capsulotomy procedure on a patient's eye. A diathermic capsulotomy tool includes a diathermic cutting element at its tip. An imaging system images the diathermic capsulotomy tool and the patient's eye. A computer processor drives a robotic unit to insert the diathermic capsulotomy tool into the patient's eye via an incision in a cornea of the patient's eye, such that the tip of the tool is disposed within the patient's eye and a remote center of motion location of the tool is disposed within the incision. The computer processor drives the robotic unit to move the cutting element in a circular motion while maintaining the remote center of motion location of the tool within the incision. Other applications are also described.

The invention discloses a center positioning system and method for a femtosecond laser ophthalmic corneal refraction operation, and relates to the technical field of image processing. The method comprises the following steps of S1, performing multi-source data synchronous acquisition on eyeballs of a patient before an operation; s2, fusing and preprocessing the collected multi-source data; s3, establishing an eyeball dynamics method, outputting six-degree-of-freedom position data in real time, and predicting the position of a laser action point; s4, dynamically adjusting the dual coordinate system according to the cornea; s5, constructing a real-time feedback system, and realizing closed-loop control, safety boundary control and a fault-tolerant mechanism; and S6, generating parameters of an operation process, constructing a four-dimensional cutting model, and performing path planning of the laser model. According to the method, the OCT, the Placido ring and the iris vein composite features are combined, the positioning precision is improved, Kalman filtering and neural network prediction compensation are utilized, eyeball movement is tracked in real time, and the accuracy of operation pupil positioning is improved.

The disclosed method that may be used for eye tracking includes measuring, by a controller, a distance to an object (316) based on a combination of polarization information of detected light and time-of-flight information of the detected light, wherein the detected light results from at least one of scattering or reflection of a light beam from the object (316). The disclosed method additionally includes performing, by an artificial reality system that includes the controller, one or more user interaction procedures based on information that includes the measured distance to the object (316). A system includes a laser scanning polarization imager including and a detector system (302) including a plurality of photodetectors 304. Each photodetector (306) includes a polarizer (308) having a particular polarization direction oriented at zero, 45, 90 and 135 degrees. A light source (310) may include a vertical cavity surface emitting laser (VCSEL) to emit a light beam (312). A reflector (314), such as a MEMS scanner, directs the light beam (312) onto the object (316), such as an eye. Light (318), e.g., specular and / or diffusive, is reflected and / or scattered from the object (316) and detected by the detector system (302). A controller measures a distance to the object (316) based on this detected light (318). Additionally, the controller measures position and / or size of one or more regions (320) of the object, such as a pupil and / or cornea.

An ophthalmic composition or dosage form can include a therapeutically effective amount of a copper-containing agent that is sufficient to increase corneal lysyl oxidase activity in an eye of a subject in an amount sufficient to treat myopic progression and a pharmaceutically acceptable carrier. The composition or dosage form can be used to treat or prevent progression of myopia by administering a therapeutically effective amount of the composition to an eye of a subject during a treatment period.

The invention relates to the technical field of multi-point defocusing, in particular to an optical stable photochromic multi-point defocusing myopia control lens prescription generation method, which comprises the following steps of: based on eyes of a wearer, scanning cornea by using a non-contact optical device, extracting iris and pupil characteristics, monitoring an adjustment reaction, and performing three-dimensional reconstruction and multi-direction light path tracking analysis to obtain a myopia control lens prescription. And the distribution configuration of the annular belt is optimized, and the overlapping area is adjusted by combining the photochromic requirement, so that the fusion function partition structure is formed. Through collection of multi-source visual parameters and combination of spatial modeling and focusing path analysis, cut-through association of individual visual behaviors and structural attributes in lens customization is realized, functional requirements of different areas and photochromic response are dynamically fused through hierarchical adjustment of the spatial structure of an intervention area, and the visual performance of the lens is improved. And the material and microstructure data are synchronously output to a manufacturing link, so that the collaborative matching capability of the visual area partition is enhanced, and the requirements of a wearer on visual comfort and optical reaction are met.

The invention belongs to the field of visual training, and particularly relates to a multispectral dynamic visual function training system and method. The multispectral dynamic visual function training system comprises an image acquisition module, an intelligent analysis module, a control module, a training execution module and a multispectral light source module, the image acquisition module is arranged at a position corresponding to an eye and is used for acquiring image information near eyeballs of a user, personal information of the user and a vision diagnosis result in real time, and the image information comprises eyeball movement tracks, pupil sizes and forms, cornea edge contours and eye white elastic states; and the intelligent analysis module combines the image information and the acquisition time of the image information. According to the scheme, through collection, analysis, regulation and control of a closed loop, the problems that in the prior art, a real-time analysis mechanism based on eyeball images is lacked, the adaptability of a training scheme and eye dynamic characteristics is weak, and precise regulation and control of functions such as light nutrition supplement and choroid stimulation cannot be achieved are solved; and precise training is also realized, and the effects of prevention and protection, cooperative improvement, compliance improvement and the like are achieved.

The present disclosure relates to an ophthalmological device for surgical treatment of a cornea of an eye, the ophthalmological device comprising a laser source, a focusing optics, a scanner system and an electronic circuit. The electronic circuit is configured to control a first scanner device of the scanner system to move the focal spot with a first scanning speed along a line, thereby forming a scan line, to control a second scanner device of the scanner system to move the scan line with a second scanning speed along a predetermined processing path, which extends inside the cornea, for treating the cornea, and to control the ophthalmological device to vary at least one of: a geometrical parameter of the scan line or a physical parameter of the scan line, along the predetermined processing path.

The invention provides an eye movement tracking method, a control unit and eye movement tracking equipment, and relates to the technical field of eye movement tracking. The method comprises the steps of obtaining a surface image of a target eyeball; extracting composite phase distribution from the surface image, wherein the composite phase distribution represents phase coupling information after the incident light is jointly modulated by a cornea interface and a crystalline lens interface of the target eyeball; based on eyeball geometric constraint and cornea interface smoothness prior, according to the composite phase distribution, constructing a decoupling objective function with separation of cornea phase distribution and crystalline lens phase distribution as a target; taking a minimum decoupling objective function as an optimization objective, and iteratively determining cornea phase distribution decoupled from crystalline lens phase distribution; and determining the visual axis direction of the target eyeball according to the cornea phase distribution. Through the double-interface phase decoupling technology, the visual axis error in a large view field and eyeball depth motion scene is effectively reduced, and the eye movement tracking precision is remarkably improved.

The present invention relates to the technical field of myopia prevention and control, and relates to a method for evaluating the effectiveness of myopia out-of-focus distribution. In order to solve the problem that the effectiveness of myopia out-of-focus distribution is rarely evaluated at present, in the present invention, analysis and induction are carried out on the basis of a large amount of clinical sample data, related parameters are determined by means of multiple regression analysis from a plurality of factors affecting an out-of-focus form, a regression equation affecting eye axis growth is obtained by using the related parameters, and finally, the distance between an out-of-focus peak value and a cornea center point is used as a core indicator for evaluating the effectiveness of myopia out-of-focus distribution, thereby providing a new idea for design and evaluation of a myopia out-of-focus distribution position in clinical practice. By using the evaluation method of the present invention, quantitative evaluation can be carried out on the out-of-focus form of an individual, and personalized out-of-focus distribution design can be carried out on the basis of the individual condition of a patient, so that myopia out of focus is distributed in an optimal position of a lens to achieve an optimal myopia prevention and control effect, and the evaluation method has great significance in early myopia prevention and control.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

A method of a biometric recognition system of performing real-eye detection, and a biometric recognition system performing the method. In an aspect, a method of a biometric recognition system of performing real-eye detection is provided. The method comprises capturing a plurality of images comprising a representation of an eye of the individual, which images are captured utilizing polarized light reflected at the eye and received at a polarization-sensitive camera capturing said images, wherein for each image being captured a different polarization rotation is selected, detecting, from the representation in each captured image, birefringent features of a cornea of the individual, and determining, by matching the detected birefringent cornea features of the captured images with the expected birefringent cornea features, whether the detected birefringent cornea features are correctly rendered in at least one of the captured images; and if so determining that the eye is a real eye.

The invention discloses a novel corneal contact lens for controlling myopia development and a processing method, the novel corneal contact lens comprises a lens body, and the lens body is divided into a central optical area and an annular light adding area; the central optical area is located in the middle area of the mirror body and is concentric with the mirror body, and the central optical area has accurate diopter and is used for correcting far vision of a wearer and ensuring that the wearer obtains clear central vision; the annular light adding area is located on the outer ring of the central optical area, the annular light adding area is provided with positive spherical lens additional degrees compared with the central optical area, and the positive spherical lens additional degrees are achieved by adding fuzzy patterns to the annular light adding area. And the annular light adding area is used for reducing the definition and contrast of an image formed around the retina by the light passing through the area. According to the corneal contact lens, myopic defocus is generated on the periphery of the retina at the same time, and the imaging contrast ratio and definition are reduced, so that the excessive growth of the ocular axis can be more effectively inhibited.

The invention relates to the technical field of medical instruments, in particular to a cornea protection eyeshade for a patient with hyperthyroidism eye disease, which comprises an eyeshade main body, the eyeshade main body comprises a support frame, a protection cover and a fitting layer are mounted on two sides of the support frame, and a self-adaptive fitting adjusting assembly, a multifunctional linkage module and a magnetic suction buffer assembly are further mounted on the support frame. The self-adaptive fitting adjusting assembly is used for driving the fitting layer to adapt to eye contours of different patients, the multifunctional linkage module is used for achieving switching of eye moisturizing and one-way light transmission of the patients, the magnetic attraction buffering assembly is used for relieving compression during wearing and fixing, and the monitoring assembly is installed on the fitting layer and used for monitoring state information of the eye contours of the patients. The monitoring assembly is in signal connection with a controller, and the controller is used for manually adjusting the moisturizing amount and the light transmission mode of the multifunctional linkage module according to the state information. According to the method, full-scene and personalized cornea protection is provided for a patient with hyperthyroidism synophthalmia, and the cornea is prevented from being damaged by exposure, dryness, strong light or compression.

The invention relates to the technical field of multi-point defocusing, in particular to an optical stable photochromic multi-point defocusing myopia control lens prescription generation method, which comprises the following steps of: based on eyes of a wearer, scanning cornea by using a non-contact optical device, extracting iris and pupil characteristics, monitoring an adjustment reaction, and performing three-dimensional reconstruction and multi-direction light path tracking analysis to obtain a myopia control lens prescription. And the distribution configuration of the annular belt is optimized, and the overlapping area is adjusted by combining the photochromic requirement, so that the fusion function partition structure is formed. Through collection of multi-source visual parameters and combination of spatial modeling and focusing path analysis, cut-through association of individual visual behaviors and structural attributes in lens customization is realized, functional requirements of different areas and photochromic response are dynamically fused through hierarchical adjustment of the spatial structure of an intervention area, and the visual performance of the lens is improved. And the material and microstructure data are synchronously output to a manufacturing link, so that the collaborative matching capability of the visual area partition is enhanced, and the requirements of a wearer on visual comfort and optical reaction are met.

The utility model provides a human eye simulation camera, and belongs to the technical field of camera shooting. The human eye simulation camera comprises a corneal lens, a simulation iris and a photosensitive element which are sequentially arranged along a photosensitive path, a simulation pupil is arranged in the center of the simulation iris, and a filtering medium for infrared cut-off is arranged between the simulation pupil and the photosensitive element. Therefore, according to the human eye simulation camera provided by the invention, unnecessary infrared light reflection can be eliminated by arranging the filtering medium, so that the recognition precision of an eye movement algorithm is improved.

The embodiment of the invention relates to the technical field of image processing, and discloses a blink detection method and device, electronic equipment and a computer readable storage medium, and the method comprises the steps: obtaining a plurality of frames of eye images; identifying the multiple frames of eye images to obtain eye parameters respectively corresponding to the multiple frames of eye images, the eye parameters including one or more of an eye angle parameter, a first distance ratio and a second distance ratio, the eye angle parameter is determined according to an inner angle of a quadrangle formed by the upper eyelid feature point, the lower eyelid feature point, the inner canthus feature point and the outer canthus feature point, the first distance ratio is determined according to a first distance between the upper eyelid feature point and the lower eyelid feature point and the cornea width, and the second distance ratio is determined according to the first distance and the second distance between the upper eyelid feature point and the lower eyelid feature point. And a second distance between the inner canthus feature point and the outer canthus feature point; and determining blinking information according to the eye parameters respectively corresponding to the plurality of frames of eye images. By implementing the embodiment of the invention, the accuracy of the determined blink information can be improved.

The invention provides a sclera lens. The sclera lens comprises an optical area, a transition area and a sclera contact area which are sequentially connected from inside to outside in the radial direction of the sclera lens. The transition area is arranged around the optical area, and the sclera contact area is arranged around the transition area; the sclera contact area is used for being attached to the sclera of the eyeball; tear storage spaces can be formed between the optical area and the cornea of the eyeball and between the transition area and the cornea of the eyeball; a wireless communication unit and a plurality of sensors are embedded in the sclera contact area, each sensor is provided with a sensing surface, and the sensing surfaces extend from the sclera contact area to the tear storage space and are attached to the transition area; the wireless communication unit is connected with the plurality of sensors and receives and sends data signals of the sensors; the data signals comprise a first electric signal for identifying ROS concentration, a second electric signal for identifying impedance or osmotic pressure and a third electric signal for identifying PH value. According to the technical scheme, tear detection is achieved, the wireless communication technology and the sensor technology are fused, and a user can conveniently obtain various key parameters of the tear.