402 results about "Cornea" patented technology

This invention discloses a 2D gaze point estimation method based on the pupil-corneal reflection vector method. It utilizes the star ray method for pupil center localization and adds a classification pupil detection mechanism for error correction. Corneal feature extraction is performed to obtain the center coordinates of the corneal reflected light spot. Step 4: Establish a gaze mapping model, and assign the detected pupil-corneal reflection vector V(V) to each frame of the image. x V y The gaze coordinates G(G) mapped onto the screen x G y This invention enables 2D gaze point estimation based on the pupil-corneal reflection vector method. Compared with existing technologies, this invention can improve the accuracy of 2D gaze point estimation.

An ophthalmic composition or dosage form can include a therapeutically effective amount of a copper-containing agent that is sufficient to increase corneal lysyl oxidase activity in an eye of a subject in an amount sufficient to treat myopic progression and a pharmaceutically acceptable carrier. The composition or dosage form can be used to treat or prevent progression of myopia by administering a therapeutically effective amount of the composition to an eye of a subject during a treatment period.

The invention relates to the technical field of multi-point defocusing, in particular to an optical stable photochromic multi-point defocusing myopia control lens prescription generation method, which comprises the following steps of: based on eyes of a wearer, scanning cornea by using a non-contact optical device, extracting iris and pupil characteristics, monitoring an adjustment reaction, and performing three-dimensional reconstruction and multi-direction light path tracking analysis to obtain a myopia control lens prescription. And the distribution configuration of the annular belt is optimized, and the overlapping area is adjusted by combining the photochromic requirement, so that the fusion function partition structure is formed. Through collection of multi-source visual parameters and combination of spatial modeling and focusing path analysis, cut-through association of individual visual behaviors and structural attributes in lens customization is realized, functional requirements of different areas and photochromic response are dynamically fused through hierarchical adjustment of the spatial structure of an intervention area, and the visual performance of the lens is improved. And the material and microstructure data are synchronously output to a manufacturing link, so that the collaborative matching capability of the visual area partition is enhanced, and the requirements of a wearer on visual comfort and optical reaction are met.

The invention provides an eye movement tracking method, a control unit and eye movement tracking equipment, and relates to the technical field of eye movement tracking. The method comprises the steps of obtaining a surface image of a target eyeball; extracting composite phase distribution from the surface image, wherein the composite phase distribution represents phase coupling information after the incident light is jointly modulated by a cornea interface and a crystalline lens interface of the target eyeball; based on eyeball geometric constraint and cornea interface smoothness prior, according to the composite phase distribution, constructing a decoupling objective function with separation of cornea phase distribution and crystalline lens phase distribution as a target; taking a minimum decoupling objective function as an optimization objective, and iteratively determining cornea phase distribution decoupled from crystalline lens phase distribution; and determining the visual axis direction of the target eyeball according to the cornea phase distribution. Through the double-interface phase decoupling technology, the visual axis error in a large view field and eyeball depth motion scene is effectively reduced, and the eye movement tracking precision is remarkably improved.

Transcorneal and fiberoptic laser delivery systems and methods for the treatment of eye diseases wherein energy is delivered by wavelengths transparent to the cornea to effect target tissues in the eye for the control of intraocular pressure in diseases such as glaucoma by delivery systems both external to and within ocular tissues. External delivery may be affected under gonioscopic control. Internal delivery may be controlled endoscopically or fiberoptically, both systems utilizing femtosecond laser energy to excise ocular tissue. The femtosecond light energy is delivered to the target tissues to be treated to effect precisely controlled photodisruption to enable portals for the outflow of aqueous fluid in the case of glaucoma in a manner which minimizes target tissue healing responses, inflammation and scarring.

The invention relates to the technical field of medical instruments, in particular to a cornea protection eyeshade for a patient with hyperthyroidism eye disease, which comprises an eyeshade main body, the eyeshade main body comprises a support frame, a protection cover and a fitting layer are mounted on two sides of the support frame, and a self-adaptive fitting adjusting assembly, a multifunctional linkage module and a magnetic suction buffer assembly are further mounted on the support frame. The self-adaptive fitting adjusting assembly is used for driving the fitting layer to adapt to eye contours of different patients, the multifunctional linkage module is used for achieving switching of eye moisturizing and one-way light transmission of the patients, the magnetic attraction buffering assembly is used for relieving compression during wearing and fixing, and the monitoring assembly is installed on the fitting layer and used for monitoring state information of the eye contours of the patients. The monitoring assembly is in signal connection with a controller, and the controller is used for manually adjusting the moisturizing amount and the light transmission mode of the multifunctional linkage module according to the state information. According to the method, full-scene and personalized cornea protection is provided for a patient with hyperthyroidism synophthalmia, and the cornea is prevented from being damaged by exposure, dryness, strong light or compression.

The invention relates to the technical field of multi-point defocusing, in particular to an optical stable photochromic multi-point defocusing myopia control lens prescription generation method, which comprises the following steps of: based on eyes of a wearer, scanning cornea by using a non-contact optical device, extracting iris and pupil characteristics, monitoring an adjustment reaction, and performing three-dimensional reconstruction and multi-direction light path tracking analysis to obtain a myopia control lens prescription. And the distribution configuration of the annular belt is optimized, and the overlapping area is adjusted by combining the photochromic requirement, so that the fusion function partition structure is formed. Through collection of multi-source visual parameters and combination of spatial modeling and focusing path analysis, cut-through association of individual visual behaviors and structural attributes in lens customization is realized, functional requirements of different areas and photochromic response are dynamically fused through hierarchical adjustment of the spatial structure of an intervention area, and the visual performance of the lens is improved. And the material and microstructure data are synchronously output to a manufacturing link, so that the collaborative matching capability of the visual area partition is enhanced, and the requirements of a wearer on visual comfort and optical reaction are met.

The utility model provides a human eye simulation camera, and belongs to the technical field of camera shooting. The human eye simulation camera comprises a corneal lens, a simulation iris and a photosensitive element which are sequentially arranged along a photosensitive path, a simulation pupil is arranged in the center of the simulation iris, and a filtering medium for infrared cut-off is arranged between the simulation pupil and the photosensitive element. Therefore, according to the human eye simulation camera provided by the invention, unnecessary infrared light reflection can be eliminated by arranging the filtering medium, so that the recognition precision of an eye movement algorithm is improved.

The invention discloses a sight tracking method and system based on cascade deep learning and distance correction, and a storage medium. The method comprises the following steps: processing an eye image through a cascade deep learning model, and obtaining pupil center coordinates and cornea reflection light spot coordinates of two eyes; calculating a binocular pixel distance as a distance correction factor based on the pupil center coordinates, and calculating a relative position difference vector based on the pupil and light spot coordinates; establishing a three-dimensional nonlinear polynomial regression model taking the relative position difference vector and the distance correction factor as input; obtaining calibration data through a multi-distance sampling strategy and solving a model coefficient; and in the real-time tracking stage, calculating the coordinates of the fixation point of the screen by using the solved model. According to the method, the distance correction factor and the three-dimensional mapping model are introduced, so that geometric errors caused by forward and backward movement of the head of the user are effectively eliminated, meanwhile, the feature point positioning precision is ensured through cascaded deep learning detection, and the precision and robustness of a sight line tracking system are remarkably improved.

Approaches are described for facilitating remote ophthalmic examinations using three-dimensional (3D) imaging and mixed reality technology. A system obtains real-time or stored 3D data of a patient's eye, capturing detailed anatomical structures. The system analyzes the 3D data to identify specific regions of the eye, such as the cornea or retina, and retrieves corresponding diagnostic data and patient-specific clinical information. The 3D data, diagnostic metrics, and clinical records are integrated to generate an interactive visualization, which is presented through a mixed reality interface. The system allows healthcare professionals to manipulate diagnostic overlays, investigate flagged abnormalities, and adjust the visualization using gesture-based inputs. Machine learning models may be applied to detect potential abnormalities in the eye, while the system also determines stages of the examination based on changes in the anatomical structure of the eye.

Methods to trigger eye enrollment without requiring good gaze interaction are described that allow a guest user of a device to initiate partial or full eye enrollment even though their eye model is not known and thus conventional gaze-based interactions do not work well. A gaze tracking system collects gaze data in the background. At any time (or within an interval after a user puts on the device), an eye enrollment can be triggered by detecting some gaze gesture, for example rolling the eyes in a large circle, or moving the eyes randomly for a time that exceeds a threshold. Depending on the coverage of the gaze / cornea data collected in the background, a full eye enrollment or only a visual axis enrollment may be performed in response to the gesture.

The application provides an illumination device for fundus observation, comprising a contact lens, a light guide plate and an illumination light source; the contact lens is provided with an arc-shaped side and a light-in side, the arc-shaped side is used for adhering to the cornea; the light-in side is provided with the light guide plate; the light guide plate is provided with a light inlet and a light outlet; the incident light of the illumination light source is incident into the light guide plate through the light inlet, the light guide plate reflects the incident light and the reflected light is incident into the contact lens through the light outlet; the incident light passes through the arc-shaped side of the contact lens and the cornea and is incident into the eyeball to illuminate the fundus. The illumination device for fundus observation of the application sets the illumination light source on the side of the contact lens and limits and adjusts the angle of the light incident into the eyeball through the light guide plate, so that the number of the light incident into the fundus is increased, and the contact fundus imaging device can form clear and accurate fundus imaging while reducing the traditional light spot interference.

A system for a full-field OCT eye measurement, comprising:—a source (1) of a light beam (2),—a detector (3), preferably in form of a camera,—an interferometer, comprising a reference arm (4) and a sample arm (5),—a beam splitter (6), configured to receive the light beam (2) and to split the light beam (2) into a sample beam (7) and a reference beam (8) and further configured to direct the sample beam (2) to the sample arm (5) and the reference beam (8) to the reference arm (4) respectively, wherein the sample arm (5) is configured for guiding the sample beam (7) through a point on the cornea of a subject's eye (9) into the subject's eye (9) and back to the detector through the beam splitter (6), wherein the reference arm (4) is configured for guiding the reference beam (8) to a mirror (10) and back to the detector (3) through the beam splitter (6), wherein said detector (3) is configured and programmed for comparing the sample beam (7) and the reference beam (8) for detecting diseases of the subject's eye (9). The system is characterized in that it comprises an arrangement for decreasing the intensity of the sample beam (7) passing through the point of the cornea of the subject's eye (9).

The invention discloses a corneal glucose real-time non-invasive detection system and method, and belongs to the technical field of glucose real-time non-invasive detection.The method comprises the following steps that corneal reflection spectrum, tear film thickness change and environment temperature and humidity data are obtained in real time, and spectrum compensation parameters are generated through a temperature and humidity compensation model; outputting a tear film refractive index correction value in combination with a refractive index correction model, and correcting the reflection spectrum through a combined correction formula; then, calculating a reference reflection spectrum and a deviation value based on historical data, extracting statistical characteristics, and fusing confidence to obtain a confidence factor for adjusting the deviation value; if the deviation exceeds the threshold value, replacing the corrected data with the reference data; and finally, calculating the glucose concentration according to the processed spectrum, and determining the health grade according to a preset comparison table. The high-reliability non-invasive blood glucose health monitoring closed-loop method and system are constructed through multi-source data fusion correction, intelligent deviation optimization and a confidence coefficient decision mechanism.

This application relates to a femtosecond laser multi-degree-of-freedom personalized reshaping method and system for intracorneal implants, belonging to the field of femtosecond laser processing technology. Utilizing the cold processing characteristics of femtosecond lasers, the intracorneal implant is individually cut and ablated to obtain the desired three-dimensional corneal shape, precisely shaping the curvature, thickness, and contour of the lens to perfectly match the patient's corneal capsule or lesion area. By leveraging the nonlinear optical effect induced at the focal point of the femtosecond laser, the stromal collagen network in the weak areas corresponding to corneal expansion can be densified through laser processing, significantly improving the local elastic modulus and resistance to deformation. In areas requiring a smooth transition with the recipient cornea or adjustment of refractive power, controllable micropores or low-density areas can be induced, appropriately reducing local stiffness, thereby achieving a spatial gradient distribution of internal mechanical properties and customizing the overall mechanical behavior and morphological stability after implantation.

The present application provides a human eye simulation camera, comprising a corneal lens, a simulated iris, and a photosensitive element which are sequentially arranged along a photosensitive path, and a filter medium for infrared cut-off is provided on the photosensitive path between the surface of the corneal lens facing away from the simulated iris and the photosensitive element. In this way, the human eye simulation camera provided by the present application, by providing the filter medium, can eliminate unnecessary infrared light reflection, thereby improving the recognition accuracy of an eye movement algorithm.

To treat corneal ectatic disorders, systems and methods can precisely apply photoactivating light to specified areas of a cornea treated with a cross-linking agent. An example system includes a light source that provides a photoactivating light to photoactivate a cross-linking agent applied to an eye. The system includes optical element(s) that transmit the photoactivating light to the eye according to a pattern defined by a plurality of treatment zones. The treatment zones are delivered to different respective areas on the eye. The plurality of treatment zones includes at least a first treatment zone and a second treatment zone. The first treatment zone provides a first dose of the photoactivating light. The second treatment zone provides a second dose of the photoactivating light. The first dose is greater than the second dose. The first treatment zone is disposed within an inner boundary of the second treatment zone.

The utility model relates to a rotary type ultrasonic emulsification instrument injection and suction handle which comprises an outer shell, a negative pressure pipe is fixed in the outer shell, one end of the negative pressure pipe extends out of the outer shell to be communicated with a negative pressure device, the negative pressure pipe is hinged to a suction pipe, the suction pipe is communicated with an inner cavity of the negative pressure pipe, and the suction pipe is driven by a driving device of the outer shell to rotate. The driving device is used for driving the suction pipe to rotate, the back side area of an incision can be adsorbed by sight lines in the process of sucking and breaking crystalline lenses, meanwhile, the infusion pipe arranged on the outer side of the suction pipe in a sleeving mode is not affected, and the suction pipe is arranged in the outer shell in a sleeving mode. And the expansion degree in the cornea is ensured.

The invention provides a nanoparticle penetrating cornea as well as a preparation method and application thereof. The nanoparticle comprises a cationic liposome G2-C14, an inner core formed by aliphatic polyester and an amphiphilic polymer, and a shell modified by polysaccharide, the hydrophobic drug and the siRNA are loaded in the inner core. According to the nano-particles provided by the invention, through polysaccharide surface modification, ocular surface adhesion and trans-epithelium transport capability are enhanced, multi-barrier penetration of the eye is realized, the nano-particles are effectively delivered to a focus area of posterior segment of the eye, the delivered siRNA targets to silence the expression of age-related macular degeneration pathogenic genes, and the hydrophobic drug removes active oxygen and inhibits release of inflammatory factors, so that the anti-aging effect of the nano-particles is improved. The focus thickness is synergistically reduced.

The utility model discloses a corneal lens cleaning tool which comprises at least one bristle structure used for cleaning a corneal lens. The supporting body is used for mounting the bristle structure; the bristle structure comprises a plurality of bristle parts and a connecting part, and the bristle parts are connected to the connecting part; the bristle part is made of a flexible material, so that the bristle part is bent when being in contact with the corneal lens, and the side wall of the bristle part is in contact with the corneal lens to clean the corneal lens; the connecting part is made of a flexible material, and the connecting part is connected to the supporting body; the cleaning effect on the lens is good, and the surface of the lens cannot be damaged.

A method of treating an eye includes delivering an OCT beam along an OCT optical path that enters a first optical subsystem along an input axis, and exits the first optical subsystem along an output axis that: 1) is substantially parallel to the optical axis of the eye, 2) is radially offset from the optical axis, and 3) extends through the cornea and into a portion of the irido-corneal angle at a point along a circumferential angle of the eye. The method also includes imaging the portion of the irido-corneal angle with the OCT beam; delivering a laser beam along an angled optical path that extends through the first optical subsystem, through the cornea, through the anterior chamber, and into a target volume of ocular tissue in the portion of the irido-corneal angle; and photodisrupting at least a portion of the target volume of ocular tissue with the laser beam.

The present application belongs to the technical field of contact lenses, and provides a contact lens containing PDRN and a preparation method thereof. The contact lens is pretreated to obtain a plasma lens; the plasma lens is sequentially soaked in a first PDRN solution, a hyaluronic acid solution, a second PDRN solution and a taurine solution to obtain a semi-finished lens; and the semi-finished lens is crosslinked to obtain the contact lens containing PDRN. Through the design of a multi-layer structure, the present application realizes the synchronous and synergistic implantation of PDRN, hyaluronic acid and taurine in the contact lens. Among them, PDRN activates the A2A adenosine receptor signaling pathway, plays a core therapeutic role in promoting corneal epithelial cell proliferation, inhibiting the release of inflammatory factors and accelerating tissue repair; hyaluronic acid plays a role in lubricating and protecting the cornea; and taurine can scavenge active oxygen free radicals and reduce oxidative stress damage.

The application discloses a diopter-adjustable and real-time retina imaging detection simulation eye, comprising: an emulated cornea, an emulated lens and an adjustable vitreous structure arranged in sequence along an optical axis; the adjustable vitreous structure comprises: a vitreous cavity filled with an emulated vitreous, a curved retina arranged at the end of the vitreous cavity, and a micrometer adjustment system for driving the curved retina to move forward and backward along the optical axis; the foveal region of the curved retina is integrated with an attenuation module and an imaging module, which are used for collecting a light spot image on the foveal region in real time; the simulation eye further comprises an analysis module electrically connected with the imaging module, and the analysis module is configured to process the collected light spot image to extract optical parameters on the curved retina.

The invention discloses a corneal contact lens with a self-healing function and a preparation method of the corneal contact lens, and belongs to the technical field of macromolecules. The preparation method comprises the following steps: dissolving a zwitterionic compound into water or a buffer solution, immersing a corneal contact lens into the solution, adding a cross-linking agent and an initiator, uniformly mixing, standing to enable molecules of the zwitterionic compound, the cross-linking agent and the initiator to be fully distributed in a spatial network of the orthokeratology lens, and polymerizing under ultraviolet irradiation to obtain the orthokeratology lens. After unreacted monomers are removed, the corneal contact lens with the self-healing function is obtained; the zwitterionic compound is one or a combination of more than two of N-(2-amino-2-oxoethyl) acrylamide, acrylamide carboxyl betaine and acrylic ester carboxyl betaine. The corneal contact lens prepared by the invention can realize self-repairing of scratches, solves the problems of bacterial hiding, corneal friction injury, frequent replacement and the like caused by surface injury of a traditional corneal contact lens, and greatly reduces the economic burden while ensuring the eye health of a wearer.

This application discloses a method and related apparatus for obtaining a phase retardation map and a fast axis orientation map of the cornea. The method includes inputting a preset polarization state into a metasurface polarization analyzer to obtain polarization measurement data output by the metasurface polarization analyzer; solving for polarization state matrix parameters based on the polarization measurement data; and decomposing the polarization state matrix parameters to obtain a phase retardation map and a fast axis orientation map of the cornea. Using this application embodiment, subtle microstructural changes in the cornea can be captured with high sensitivity, compensating for the lack of quantitative analysis methods in traditional slit-lamp examinations, while effectively overcoming the problem of insufficient accessibility caused by the large size and high cost of traditional high-end detection equipment.

A UV-laser-based system (UVL-LVC system) for correcting the impaired vision of a patient's eye has a UV-laser source, which emits laser radiation to treat the patient's eye, and imaging optics for focusing the laser radiation onto the cornea of the patient's eye. The imaging optics allow a detection of a reflection of radiation, which is emitted onto the cornea of the patient's eye with the imaging optics and is at least partly reflected by the cornea of the patient's eye back into the imaging optics at an acceptance angle χMax of at least 2.5°. Additionally a method for centering a UVL-LVC system is disclosed.

The non-intrusive measuring system for the glucose concentration of the aqueous humor of the eyes comprises a linear polarization collimation light source which emits an incident polarized light beam along an advancing optical axis at a linear polarization starting angle, penetrates through a cornea, enters the aqueous humor and generates an emergent polarized light beam; the linear polarization starting angle of the incident polarized light beam is defined as a 45-degree rotation angle along the advancing direction of the advancing optical axis; the first polarization beam splitter is used for splitting the emergent polarized light beam into two emergent polarized light beam components with orthogonal polarization directions, and the two emergent polarized light beam components are respectively polarized at 0-degree and 90-degree rotation angles along respective advancing optical axis directions; the two light sensors are used for respectively measuring the light intensity of the two emergent polarized light beam components; an arithmetic processor for subtracting the light intensity to obtain a Schtort vector S1 component related to the amount of rotation of the polarization angle; and normalizing the S1 component by adding the light intensities of the emitted polarized light beam components as a standard value.

Disclosed is a tonometer (100) for measuring intraocular pressure of an eye (150), the tonometer comprising: an air pulse generator (102); a corneal oscillation measurement sensor (104), and a controller (106) communicably coupled to air pulse generator and corneal oscillation measurement sensor, wherein the controller is configured to: control the air pulse generator to provide an excitation air pulse (108) towards a cornea (152) of the eye during a first time period (T1), wherein provided excitation air pulse has a first intensity (I) at an end time (T1e) of first time period, and this intensity is reduced from first intensity to a second intensity during a second time period (T2), wherein the second time period is after first time period, for producing corneal oscillations (320, 330); measure a signal related to corneal oscillations, using corneal oscillation measurement sensor; and determine intraocular pressure from measured signal.

The present invention provides an intraocular lens and related technologies, which have regions concentric with a lens center O, including at least one distance region for correcting visual acuity for distance vision and at least one near region for correcting visual acuity for near vision, wherein the power in the distance region is reduced to provide a negative vertical spherical aberration that at least partially offsets the positive vertical spherical aberration caused by the cornea, and the near region has a predetermined base power at the lens center O and adds a positive fixed power to an aspherical reference power within a predetermined radial range of a virtual aspherical lens that completely offsets the positive vertical spherical aberration caused by the cornea, and the near region has at least three sub-regions arranged radially, wherein sub-region 1 provides a positive power deviation for the positive fixed power, sub-region 2 provides an approximately zero power deviation for the positive fixed power, and sub-region 3 provides a negative power deviation for the positive fixed power.