59 results about "Repair tissue" patented technology

A system for surgically augmenting tissue of a patient has a patch configured to integrate with the tissue being repaired and an expandable member defining a longitudinal axis. The patch includes patch material that progressively integrates with tissue of the patient at least in part via biological processes in the patient. The system also has a suture channel extending through the expandable portion in a direction generally parallel to the longitudinal axis of the expandable portion. The suture channel has a first end and a second end sized and configured to receive and pass a suture therethrough.

The invention provides improved devices, systems, and methods for tissue approximation and repair at treatment sites. The invention provides devices, systems, and methods that may more successfully approximate and repair tissue by improving the capture of tissue into the devices. The invention may be a one-way mechanism that allows tissue to enter the mechanism but not easily exit, such as a leaf-spring, a protrusion, a pivoting arm and one or more frictional elements.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

A suturing apparatus may include a shaft member having a lumen, and a first jaw member and a second jaw member that move between an open configuration and a closed configuration. A distal portion of the first jaw member may be pivotably connected to a distal portion of the second jaw member, and the distal portion of the second jaw member may have a distal opening. The suturing apparatus may further include a needle translates through the lumen of the shaft member and carries a suture, and a retention member in the distal opening of the second jaw member to remove the suture from the needle. The suture may be wrapped around the distal portion of the second jaw member. The suturing apparatus may be included in a suturing system having a suture. The suturing apparatus may be used in a method of repairing tissue.

A method of repairing tissue of a patient secures at least two sutures to two initial points of the patient, and couples sutures to a repair matrix comprising a scaffold portion and an expandable portion. The scaffold portion is configured to integrate over time with the tissue being repaired. The method also expands the expandable portion to urge the repair matrix against the tissue to produce a securing surface, and then secures the at least two sutures to two additional points of the patient. The at least two sutures traverse the securing surface of the repair matrix between the two initial points and the two additional points to secure the repair matrix to the patient.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

A suture assembly comprises a suture anchor, a repair suture, and a shuttle suture. Each suture has a looped end and a tail end. The tail end of the repair suture and the looped end of the shuttle suture extend out one side of the proximal end of the anchor, while the looped end of the repair suture and the tail end of the shuttle suture extend out the opposite side of the anchor. A method of repairing tissue includes implanting the suture anchor into a bone below and to one side of the tissue; passing the tail of the repair suture between a detached tissue and a bone, and then back over the detached tissue and through the loop of the repair suture to create a luggage tag construct before locking the tail of the repair suture against a portion of the suture anchor.

A tissue repair device, system, and method for grasping tissue, such as to repair the tissue (e.g., a defect in tissue), by anchoring a tissue-penetrating arm along a first location along the tissue, moving the anchored tissue-penetrating arm to a second location along the tissue, and grasping tissue at the second location with a tissue-grasping arm. The tissue-penetrating arm remains in a substantially axial straight configuration to facilitate tissue penetration. The tissue-grasping arm is movable towards and away from the tissue-penetrating arm to grasp tissue and hold the grasped tissue between the tissue-grasping arm and the tissue-penetrating arm. The tissue repair device may be left in place holding the tissue in the grasped configuration.

The present disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bioabsorbable material wherein the implant surface is considered hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface, and wherein the implant surface is not hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface. Wherein the ink test comprises incubating the implant in a solution consisting of an ink having a surface tension of 72 mN / m and water for 1 minute, and wherein after the implant is incubated in the solution, the ink colored implant surface is an indication of a hydrophilic implant surface. The disclosure also provides the implant for tissue reconstruction, (soft) tissue support, tissue compatibilization and / or implant repair, and the use of the implant for reconstruction, compatibilization and / or repair of tissue and / or support of (soft) tissue, respectively, where the implant is embedded in a patient. The present disclosure further provides a method of manufacturing a tissue reconstruction implant having a hydrophilic implant surface.

Described herein are methods for preparing collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are slurries and implants prepared by such methods.

Disclosed herein is a kit for manufacturing a scaffold for repairing tissue in a living being. The kit includes a structural reinforcing element. The structural reinforcing element is selected from i) at least one rod; or ii) a plurality of rods and brackets that are operative to be assembled into a cage. It comprises a plurality of module elements that can be assembled to form at least one module, where the module upon assembly contacts the structural reinforcing element. The module includes a plurality of curved ribs of different sizes that extend concentrically in a first direction when assembled. It also contains a spacing element that is operative to contact the plurality of curved ribs when assembled; where the spacing element extends in a second direction that is inclined at an angle to the first direction. The spacing element is operative to keep successive neighboring modules apart from one another.

A system for surgically augmenting tissue of a patient includes a patch configured to integrate with the tissue being repaired, and an expandable member associated with the patch. The patch includes a patch material that progressively integrates with tissue of the patient. In a similar manner, the expandable member is formed of a member material that progressively degrades within the patient at least in part via biological processes of the patient. The expandable member is configured to urge the patch toward the tissue after placement in or on the patient.

The present invention discloses an inducer, macrophages, and their applications, relating to the interdisciplinary fields of immunology, cell biology, and regenerative medicine. The invention utilizes a composition composed of osteopontin (OPN) and other cytokines to culture and induce monocytes, thereby generating macrophages with strong repair functions. These macrophages can be used to repair tissue wounds, promoting the healing and tissue regeneration of chronic, difficult-to-heal wounds, and exhibiting excellent repair effects, making them suitable for widespread application.

The invention discloses a macrophage hybrid scaffold as well as a construction method and application thereof, and belongs to the technical field of biological materials. The construction method comprises the following steps: extracting peripheral blood mononuclear cells, inducing the peripheral blood mononuclear cells into mature macrophages, loading the mature macrophages on a tissue engineering scaffold, and adding an immunoregulation factor to regulate the phenotype of the mature macrophages to obtain the M2 type macrophage hybrid scaffold. According to the invention, the macrophages with an immunoregulation effect are introduced into the tissue engineering scaffold, the macrophage hybrid scaffold is constructed together, and the macrophage hybrid scaffold can be used for repairing tissue defects, such as defect tissues such as skin, mucous membrane, viscera, cartilage or hard bone and the like; the macrophage hybrid scaffold can meet various requirements of providing mechanical support and bioremediation functions for tissue defect areas.

Provided herein are bioresorbable, bioregenerative composite materials and compositions to regenerate tissues or organs to repair tissue or organ defects and constructs printed from the same as 3D structures shaped and sized to fill a tissue or organ defect. The composite materials are bioresorbable polymers, for example, polycaprolactone, and a bioresorbable graft material, for example, demineralized bone matrix. Also provided are methods for making the composite materials and compositions and methods for regenerating tissues or organs and repairing a tissue or organ defect using the constructs.

The present invention provides a slender anchor for fixing sutures to tissue and a system for deploying the slender anchor. The slender anchor includes a first opening, a second opening, a wire passage extending from the first opening to the second opening, and a first wire embedding space extending axially. The first wire embedding space is connected to the first opening. The distal end of the suture enters the wire passage through the first opening and exits from the second opening to attach to the slender anchor; the extended end of the suture selectively switches between being accommodated in the first wire embedding space and being detached from the first wire embedding space. The slender anchor and system provided by the present invention not only reduce damage to tissue, but also further ensure the effectiveness of tissue repair.

A tissue repair construct, having a repair strand, defining a lumen and having a first end defining an opening of the lumen and a second end opposed to the first end. Further, a shuttle having a loop at a first end and a pull end, opposed to the first end, is engaged through the lumen of the repair strand, entering at the opening and exiting at a broach point through the repair strand, the loop extending out of the opening and the pull end being coincident to the second end of the repair strand. The tissue repair construct forming a tight loop to approximate the tissue extents and repairing the tissue tear.

Provided are tissue repair and sealing devices, and methods for the use of tissue repair and sealing devices, for use in both minimally invasive surgical (MIS) procedures and open, non-MIS procedures to rapidly repair tissue fenestrations and create a pressure-resistant, watertight seal in a tissue barrier. Tissue repair and sealing devices disclosed herein comprise an integrated graft and deployable clasp assembly and an applicator assembly having a clasp retain and release member that is slidably connected to a folded, deployable clasp. The applicator assembly places a graft on a tissue inner surface and a deployable clasp on a tissue outer surface to secure the graft to the tissue inner surface to, thereby, repair a tissue fenestration and create a watertight barrier.

The invention provides a polypeptide PN-VW22 and application thereof, and belongs to the technical field of polypeptide drugs. The polypeptide PN-VW22 provided by the invention is specifically as follows A1) or A2): A1) an amino acid sequence as shown in SEQ ID NO.1; a2) a fusion protein obtained by connecting a label to the N end or / and C end of A1). The polypeptide has obvious cell proliferation activity and anti-staphylococcus aureus bifunctional activity, and also has a wound repairing effect. The polypeptide is small in molecular weight and stable in structure, can be industrially produced through solid-phase chemical synthesis, can also be industrially applied to preparation of treatment medicines for promoting skin wound repair, and can be used as a candidate polypeptide medicine or a medical beauty product raw material for treating body surface wounds, repairing tissues, burns and skin ulcers, reducing scars and accelerating scar repair.

An implantable prosthesis for covering a defect in the peritoneum. The prosthesis may include a body (22) of implantable biocompatible material having a first surface (24) and a second surface (26). The first surface is tissue permeable and the second surface is adhesion resistant. The body includes a clip region adjacent an outer perimeter thereof having tissue clips (28) protruding in an outward direction away from the second surface. The prosthesis may be positioned between the peritoneum and a separate hernia repair fabric located in the anterior peritoneal pocket for repairing tissue or muscle wall defects, such as abdominal hernia.

A method for repairing a tissue. The method can improve the ability of a surgeon to load a suture into a device and unload the suture from the device. A suture retainer can maintain the suture in place with respect to the device.

The invention discloses a traditional Chinese medicine concentrated solution for cell energy activation type scoliosis and a preparation process, and relates to the technical field of traditional Chinese medicine processing. The traditional Chinese medicine concentrated solution is prepared from the following raw materials in parts by weight: 100-140 parts of radix dipsaci, 80-120 parts of cortex eucommiae, 130-170 parts of radix astragali, 60-100 parts of radix angelicae sinensis, 50-70 parts of rhizoma chuanxiong, 60-80 parts of radix angelicae pubescentis, 80-100 parts of fructus lycii, 40-60 parts of radix glycyrrhizae and 15-25 parts of activation auxiliary materials. Himalayan teasel root and eucommia ulmoides in the formula are core components for strengthening muscles and bones and can enhance the toughness of ligaments and tendons around the spine; radix astragali can tonify qi, angelica sinensis can nourish blood, local blood circulation of the spine can be improved, and nutrition is provided for tissue repair; ligusticum wallichii can promote blood circulation to remove meridian obstruction, radix angelicae pubescentis can expel wind-damp, and inflammation and adhesion of soft tissues around The Chinese wolfberry fruits can nourish the liver and the kidney, the licorice roots are matched to harmonize all the medicines, the added activating auxiliary material semen cuscutae extract can activate energy metabolism of osteoblasts and chondrocytes around the spine in a targeted mode, collagen synthesis and calcium deposition are promoted, and tissue damage related to spine malformation is repaired from the cellular level.

An implantable prosthesis for repairing tissue defects includes a layer of repair fabric and a plurality of microtextured grip segments mounted to the repair fabric. The grip segments include a pattern of perforations on a tissue facing surface to promote tissue ingrowth.

An implantable prosthesis for repairing tissue defects includes a layer made of a repair fabric and a plurality of microtextured gripping sections mounted to the repair fabric. The gripping section includes perforations on the tissue-facing surface to promote tissue ingrowth.

The present invention discloses an absorbable stent system, which comprises an absorbable stent and a repair substance. The absorbable stent is made of a biodegradable material, and the repair substance is connected to the absorbable stent. The repair substance is used to repair tissues at a target site. The present invention provides an absorbable stent system, which can repair cells and tissues at corresponding positions while treating the target site, and has high structural strength.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

The application relates to a method for inducing mesenchymal stem cells to differentiate into chondroblasts and a composition for promoting regeneration of articular cartilage and application, and belongs to the technical field of biomedical materials. The method for inducing mesenchymal stem cells to differentiate into chondroblasts comprises the following steps: inoculating and culturing on a substrate, wherein the surface of the substrate is provided with a plurality of convex blocks, the plurality of convex blocks are arranged at equal intervals along any extension direction of the surface of the substrate; the height of the convex blocks is not greater than 2 mu m, the ratio of the width of the convex blocks to the interval between adjacent two convex blocks is 1:0.8-1.2, and the interval between the adjacent two convex blocks is not less than 25 mu m; the method further comprises the following steps: spreading mesenchymal stem cells to the surface of the substrate for culture to obtain mesenchymal stem cells with mechanical memory of chondroblast differentiation; and the surface of the substrate comprises the surface of the convex blocks and the surface of the concave parts between the convex blocks. The method can promote the chondroblast differentiation of mesenchymal stem cells, make the subsequently formed repair tissue more close to the original cartilage, and has the advantages of simple operation, high cell survival rate and stable effect.

The application provides a tissue staining method based on antigen repair treatment combined with silver staining, comprising the following steps: a) high-temperature heat repair of a tissue section to be treated with an antigen repair solution, and washing with water after cooling to obtain a repaired tissue section; b) silver staining of the repaired tissue section obtained in step a), dehydration, and then mounting to obtain a stained tissue section. Compared with the prior art, the tissue staining method based on antigen repair treatment combined with silver staining provided by the application adopts specific process steps and conditions to realize overall good interaction: first, the brain tissue is subjected to antigen repair treatment, and then the silver staining technology is adopted, which significantly improves the signal-to-noise ratio of the senile plaque region, and ideal staining effect is obtained, which can effectively improve the detail visibility in pathological detection, help more accurately evaluate the morphology and distribution characteristics of the senile plaque, and has a wide application prospect.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

Described herein are methods for preparing collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are slurries and implants prepared by such methods.