23 results about "Repair tissue" patented technology

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

A suturing apparatus may include a shaft member having a lumen, and a first jaw member and a second jaw member that move between an open configuration and a closed configuration. A distal portion of the first jaw member may be pivotably connected to a distal portion of the second jaw member, and the distal portion of the second jaw member may have a distal opening. The suturing apparatus may further include a needle translates through the lumen of the shaft member and carries a suture, and a retention member in the distal opening of the second jaw member to remove the suture from the needle. The suture may be wrapped around the distal portion of the second jaw member. The suturing apparatus may be included in a suturing system having a suture. The suturing apparatus may be used in a method of repairing tissue.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

The present disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bioabsorbable material wherein the implant surface is considered hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface, and wherein the implant surface is not hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface. Wherein the ink test comprises incubating the implant in a solution consisting of an ink having a surface tension of 72 mN / m and water for 1 minute, and wherein after the implant is incubated in the solution, the ink colored implant surface is an indication of a hydrophilic implant surface. The disclosure also provides the implant for tissue reconstruction, (soft) tissue support, tissue compatibilization and / or implant repair, and the use of the implant for reconstruction, compatibilization and / or repair of tissue and / or support of (soft) tissue, respectively, where the implant is embedded in a patient. The present disclosure further provides a method of manufacturing a tissue reconstruction implant having a hydrophilic implant surface.

Described herein are methods for preparing collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are slurries and implants prepared by such methods.

A tissue repair construct, having a repair strand, defining a lumen and having a first end defining an opening of the lumen and a second end opposed to the first end. Further, a shuttle having a loop at a first end and a pull end, opposed to the first end, is engaged through the lumen of the repair strand, entering at the opening and exiting at a broach point through the repair strand, the loop extending out of the opening and the pull end being coincident to the second end of the repair strand. The tissue repair construct forming a tight loop to approximate the tissue extents and repairing the tissue tear.

The invention discloses a traditional Chinese medicine concentrated solution for cell energy activation type scoliosis and a preparation process, and relates to the technical field of traditional Chinese medicine processing. The traditional Chinese medicine concentrated solution is prepared from the following raw materials in parts by weight: 100-140 parts of radix dipsaci, 80-120 parts of cortex eucommiae, 130-170 parts of radix astragali, 60-100 parts of radix angelicae sinensis, 50-70 parts of rhizoma chuanxiong, 60-80 parts of radix angelicae pubescentis, 80-100 parts of fructus lycii, 40-60 parts of radix glycyrrhizae and 15-25 parts of activation auxiliary materials. Himalayan teasel root and eucommia ulmoides in the formula are core components for strengthening muscles and bones and can enhance the toughness of ligaments and tendons around the spine; radix astragali can tonify qi, angelica sinensis can nourish blood, local blood circulation of the spine can be improved, and nutrition is provided for tissue repair; ligusticum wallichii can promote blood circulation to remove meridian obstruction, radix angelicae pubescentis can expel wind-damp, and inflammation and adhesion of soft tissues around The Chinese wolfberry fruits can nourish the liver and the kidney, the licorice roots are matched to harmonize all the medicines, the added activating auxiliary material semen cuscutae extract can activate energy metabolism of osteoblasts and chondrocytes around the spine in a targeted mode, collagen synthesis and calcium deposition are promoted, and tissue damage related to spine malformation is repaired from the cellular level.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

The application provides a tissue staining method based on antigen repair treatment combined with silver staining, comprising the following steps: a) high-temperature heat repair of a tissue section to be treated with an antigen repair solution, and washing with water after cooling to obtain a repaired tissue section; b) silver staining of the repaired tissue section obtained in step a), dehydration, and then mounting to obtain a stained tissue section. Compared with the prior art, the tissue staining method based on antigen repair treatment combined with silver staining provided by the application adopts specific process steps and conditions to realize overall good interaction: first, the brain tissue is subjected to antigen repair treatment, and then the silver staining technology is adopted, which significantly improves the signal-to-noise ratio of the senile plaque region, and ideal staining effect is obtained, which can effectively improve the detail visibility in pathological detection, help more accurately evaluate the morphology and distribution characteristics of the senile plaque, and has a wide application prospect.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

Described herein are methods for preparing collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are slurries and implants prepared by such methods.

A suturing apparatus may include a shaft member having a lumen, and a first jaw member and a second jaw member that move between an open configuration and a closed configuration. A distal portion of the first jaw member may be pivotably connected to a distal portion of the second jaw member, and the distal portion of the second jaw member may have a distal opening. The suturing apparatus may further include a needle translates through the lumen of the shaft member and carries a suture, and a retention member in the distal opening of the second jaw member to remove the suture from the needle. The suture may be wrapped around the distal portion of the second jaw member. The suturing apparatus may be included in a suturing system having a suture. The suturing apparatus may be used in a method of repairing tissue.

Technologies are disclosed for an implant device that may be configured to repair tissue. The device may include a distal end configured to be connectable to at least a first part of the tissue. The device may include a proximate end configured to be connectable to at least a second part of the tissue. The device may include a substrate configured to form a connection between the first part of the tissue and the second part of the tissue. The device may include a longitudinal axis that may extend between the distal end to the proximate end within the substrate. The device may include at least one preformed channel in the substrate. The device may include at least one suture preloaded at least partially within the at least one channel. The at least one preformed channel may be formed during and / or proximate to a formation of the device.

The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and / or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

The application relates to the field of medical devices, in particular to a repair system, which at least comprises a double-puncture structure, a catching device and a repair unit connected with the double-puncture structure, the double-puncture structure is used for guiding the repair unit, and the double-puncture structure can pass through the tissue to be repaired back and forth in the repair process; the catching device is arranged on the side of the starting point of the first puncture of the double-puncture structure in the repair process and is abutted against the tissue, so that the tissue for the second puncture of the double-puncture structure is provided with a supporting force, and thus the tissue for the second puncture is provided with the supporting force and the puncture force from the proximal end and the distal end directions respectively, the double-puncture structure can smoothly puncture at the target position, the accuracy of the puncture point is guaranteed, and the catching device is also responsible for catching the repair unit after the second puncture.

The invention discloses a human mesenchymal stem cell preparation activated by specific immune pretreatment and application thereof, and the application is characterized in that human mesenchymal stem cells (hAMSCs) and autologous human peripheral blood lymphocytes are co-cultured and pretreated according to a specific ratio (such as 100: 1), and then are applied to a knee osteoarthritis model through intra-articular injection. The synergistic treatment effect which is obviously superior to that of the unpretreated hAMSCs can be generated; the Co-hAMSCs show a unique in-vivo action mode, the survival time of the Co-hAMSCs at the local part of the joint is shorter than that of common hAMSCs, but the Co-hAMSCs can quickly relieve pain in the early treatment stage, improve the joint function and lower local inflammation; the cartilage repair and regeneration can be more effectively promoted for a long time, and the specific expression is as follows: the cartilage histological score is obviously improved, the content of cartilage matrix glycosaminoglycans (especially middle and deep layers) is increased, and the repaired tissue is guided to be transformed to a hyaline cartilage sample phenotype with high expression of type II collagen and low expression of type I collagen, so that the cartilage repair and regeneration can be more effectively promoted. And inflammatory factor balance of local joints and the whole body can be synchronously adjusted.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

Technologies are disclosed for an implant device that may be configured to repair tissue. The device may include a distal end configured to be connectable to at least a first part of the tissue. The device may include a proximate end configured to be connectable to at least a second part of the tissue. The device may include a substrate configured to form a connection between the first part of the tissue and the second part of the tissue. The device may include a longitudinal axis that may extend between the distal end to the proximate end within the substrate. The device may include at least one preformed channel in the substrate. The device may include at least one suture preloaded at least partially within the at least one channel. The at least one preformed channel may be formed during and / or proximate to a formation of the device.

A tissue repair system is disclosed, comprising a collagen implant designed for repair of tissues, including meniscal tears and rotator cuffs, formed from self-assembled collagen fibers without cross-linking agents. The implant is absorbent and has structural integrity for suture securement. It is delivered through a specialized device, with sutures for securement. A delivery device, suture passer, and syringe are integral components of the system. The method involves accessing the tissue site, securing sutures, positioning and securing the implant, and injecting blood for tissue repair. The system and method facilitate tissue regeneration and repair in a minimally invasive manner, allowing for the growth of healthy tissue at the injury site, particularly for anterior cruciate ligament (ACL) and meniscus repair.