218 results about "Repair tissue" patented technology

The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and / or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

A biocompatible tissue repair stimulating implant or "scaffold" device is used to repair tissue injuries, particularly injuries to ligaments, tendons, and nerves. Such implants are especially useful in methods that involve surgical procedures to repair injuries to ligament, tendon, and nerve tissue in the hand and foot. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair.

Self-supporting, shaped, three-dimensional cross-linked proteinaceous biopolymeric materials that may be implanted in vivo, and methods of making such materials are disclosed. The biopolymeric materials most preferably include reinforcing media, such as biocompatible fibrous or particulate materials. In use, the preformed, shaped biopolymeric materials may be applied to tissue in need of repair and then sealed around its edges with a liquid bioadhesive. In such a manner, repaired tissue which is capable of withstanding physiological pressures may be provided.

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. The device can have multiple flat sides that remain flat during expansion. A method of repairing tissue is also disclosed. Devices and methods for adjusting (e.g., removing, repositioning, resizing) deployed orthopedic expandable support devices are also disclosed. The expandable support devices can be engaged by an engagement device. The engagement device can longitudinally expand the expandable support device. The expandable support device can be longitudinally expanded until the expandable support device is substantially in a pre-deployed configuration. The expandable support device can be then be physically translated and / or rotated.

The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of a patient.

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.

A suture anchor system for repairing torn or damaged tissue is provided and generally includes a first suture anchor having at least one length of suture attached thereto, and a second suture anchor having at least one length of suture attached thereto. Each length of suture is coupled to one another such that a distance between the first and second suture anchors with respect to each other can be selectively adjustable. The suture anchor system also preferably includes at least one slip knot that allows the first and second suture anchors to be maintained in a fixed position with respect to one another. In use, the suture anchors can be deployed through tissue to be repaired and into the anchoring tissue at a position spaced apart from one another by a selected distance. The suture length(s) can then be tensioned to re-approximate the torn or damaged tissue toward the anchoring tissue, thereby securely attached the torn tissue to the anchoring tissue.

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.

A suture anchor system for repairing torn or damaged tissue is provided and generally includes a first suture anchor having at least one length of suture attached thereto, and a second suture anchor having at least one length of suture attached thereto. Each length of suture is coupled to one another such that a distance between the first and second suture anchors with respect to each other can be selectively adjustable. The suture anchor system also preferably includes at least one slip knot that allows the first and second suture anchors to be maintained in a fixed position with respect to one another. In use, the suture anchors can be deployed through tissue to be repaired and into the anchoring tissue at a position spaced apart from one another by a selected distance. The suture length(s) can then be tensioned to re-approximate the torn or damaged tissue toward the anchoring tissue, thereby securely attached the torn tissue to the anchoring tissue.

Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and / or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.

An expandable support device, such as an ultra thin expanding stent device, for tissue repair is disclosed. The expandable support device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The expandable support device can have a substantially flat top plate and a substantially flat bottom plate. The top plate can be attached to the bottom plate by expandable struts.

The present system is directed to a method and system to stabilize and repair tissue. At least two opposing devices may be used to stabilize and repair the tissue, with the two devices cooperatively engaging the tissue interposed therebetween. Stabilization may be accomplished by opposing force, vacuum force, or mechanical devices disposed at the distal portion of one or both devices. After the tissue has been stabilized, fasteners may be deployed into the tissue. Fasteners include sutures, clips, and staples. Also disclosed is a minimally invasive method of accessing tissue located within a body and conducting a repair of the area using the system disclosed herein.

Compositions and methods of treating a defect in a patient are disclosed, including expanding a culture of autologous cells in vitro to form cultured cells, collecting the cultured cells for introduction into the patient, and depositing the cultured cells with ancillary proteins.

A biocompatible surgical fastener, comprising a sleeve and a screw or a pin, which expands when it is implanted in a patient. The sleeve is first implanted in a pre-drilled hole in the operating area of a patient, usually in a bone, cartilage or a bone and cartilage. When a screw or a pin is installed in the sleeve, the sleeve is caused to expand thereby stabilizing the fastener in the operating area. In many embodiments the screw or pin can be removed and reinserted without disturbing the tissue in the operating area. The surgical fastener can be used to repair tissue or to secure other implant devices in a patient.

Described herein are methods of repairing tissue using a continuous suture passer. In particular, described herein are methods for forming complex suture patterns using a continuous suture passer. The continuous suture passer is typically configured so that the tissue penetrating element (e.g., needle) may be completely withdrawn into the device. The continuous suture passer may be configured as a grasper having two jaws, wherein the tissue penetrating member may pass the suture between the two jaws. The jaws may open and close so that the tissue contacting surfaces of the jaws are parallel, and so that the suture may be passed between the jaws when they are in any position.

The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.

Assemblies and methods suitable for knotless arthroscopic repair of tissue defects include two fixation members coupled by two limbs of suture comprising a continuous loop. A unidirectional restriction element that can be a preformed locking, sliding suture knot proximate to one of the fixation members, provides tensioning of the repair.

Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.

One or more tine plates for repairing tissue (e.g. hand / wrist tendons). Each plate has a center portion includes fenestrations, and / or a width or thickness that is less than that of first and second end portions of the plate, such that the center portion is more pliable than the first and second end portions. A first plurality of tines extends from the first end portion non-orthogonally and angled toward the center portion, and a second plurality of tines extends from the second end portion non-orthogonally and angled toward the center portion. A suture, button or ring are used to affix the plate(s) to the tendon, which the plate(s) extending across a sever point to serve as the load-bearing member, wherein the tines are positioned on both sides of the tendon sever point for fixating the tissue.

Expandable support devices for tissue repair are disclosed. The devices can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. Surgical devices and methods for adjusting (e.g., removing, repositioning, resizing) deployed orthopedic expandable support devices are also disclosed. The expandable support devices can be engaged and surgically implanted by an engagement device and affixed to bone to provide stability and support for the devices. The expandable support devices are attachable to spinal fixation devices such as screws or plates, and may be used to support such devices when placed in weakened or damaged areas of bone.

A method and apparatus relating to a biocompatible soft tissue implant is disclosed. The implant, in the form of a prosthesis, is constructed of a knitted pile mesh material arranged into either a 3-dimensional structure or a planar shape or structure. The material or fabric includes a plurality of filament extensions projecting outwardly therefrom. The filament extensions can be radially projecting looping filaments from one or more rows of the knitted pile mesh material. The combination of the filament extensions with the 3-dimensional structure results in the biocompatible implant having a structural resistance to hinder anticipated crushing forces applied to the implant, and also provide a suitable 3-dimensional structure for promoting rapid tissue in-growth to anchor such implant without migration and strengthen the repaired tissue area.

Repairs of cartilage defects or of cartilage / bone defects in human or animal joints with the help of devices including a bone part (1), a cartilage layer (2) and a subchondral bone plate (4) or an imitation of such a plate in the transition region between the cartilage layer (2) and the bone part (1). After implantation, the bone part (4) is resorbed and is replaced by reparative tissue only after being essentially totally resorbed. In a critical phase of the healing process, a mechanically inferior cyst is located in the place of the implanted bone part (1). In order to prevent the cartilage layer (2) from sinking into the cyst space during this critical phase of the healing process the device has a top part (11) and a bottom part (12), wherein the top part (11) consists essentially of the cartilage layer (2) and the subchondral bone plate (4) and the bottom part (12) corresponds essentially to the bone part (1) and wherein the top part (11) parallel to the subchondral bone plate (4) has a larger diameter than the bottom part (12). After implantation in a suitable opening or bore (20), the cartilage layer (2) and the subchondral bone plate (4) are supported not only on the bone part (1) but also on native bone tissue having a loading capacity not changing during the healing process. Therefore, the implanted cartilage layer cannot sink during the healing process.

The present invention relates to a biocompatible, three-dimensional scaffold useful to grow cells and to regenerate or repair tissue in predetermined orientations. The scaffold is particularly useful for regeneration and repair of cardiac tissue. The scaffold contains layers of alternating A-strips and S-strips, wherein the A-strips within each layer are aligned parallel to each other and preferentially promote cellular attachment over attachment to the S-strips. Methods of producing and implanting the scaffold are also provided.

Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and / or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.

An antibacterial nano-class fibre material contains superfine high-molecular fibres (60-98 wt.%) and antibacterial agent (2-40 wt.%), and is prepared through dispersing or dissolving one or more high-molecular material in solvent to become transparent solution or mixture, dispersing the superfine particle of antibacterial agent (less than 20 microns) in said solution, and electric spinning. It can be used as protecting material, disinfecting filter material and tissue covering material for repairing tissue or promoting healing of tissue.

A prosthesis and a method for repairing a tissue or muscle wall defect, such as an inguinal hernia, near a cord-like structure, such as the spermatic cord. The prosthesis comprises a layer of repair fabric having a cord opening therethrough that is adapted to receive the cord-like structure when the prosthesis is implanted at the repair site. The prosthesis also includes a cord protector that is attachable to the repair fabric at the opening to isolate the cord-like structure from the fabric in proximity to the opening. The repair fabric may be formed from a material which is susceptible to the formation of adhesions with sensitive tissue and organs. The cord protector may be formed from material which inhibits the formation of adhesions with sensitive tissue and organs. The cord protector may overlie a portion of at least one of the first and second surfaces of the repair fabric. The cord protector may extend substantially farther away from the opening edge on one of the first and second surfaces than on the other of the first and second surfaces. The cord protector may be configured as an insert that is separate from and attachable to the repair fabric. Alternatively, the cord protector may be integral with the repair fabric to form a composite prosthesis.

The present invention is directed to various systems for repairing tissue within the heart of a patient. The mitral valve repair system of the present invention comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. In addition, the present invention discloses various methods for repairing tissue within the heart of a patient. In one embodiment, the method of repairing heart valve tissue includes advancing a guide catheter through a circulatory pathway to a location in the heart proximate to a heart valve, advancing a therapy catheter through the guide catheter to the heart valve, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.