43 results about "Repair tissue" patented technology

A system for surgically augmenting tissue of a patient has a patch configured to integrate with the tissue being repaired and an expandable member defining a longitudinal axis. The patch includes patch material that progressively integrates with tissue of the patient at least in part via biological processes in the patient. The system also has a suture channel extending through the expandable portion in a direction generally parallel to the longitudinal axis of the expandable portion. The suture channel has a first end and a second end sized and configured to receive and pass a suture therethrough.

The invention relates to a tissue engineering articular cartilage simulating a four-layer structure of a natural cartilage and an in-situ 3D printing method of the tissue engineering articular cartilage, the structure and component characteristics of'surface layer-transitional layer-radiation layer-calcification layer 'of the natural cartilage are re-carved through precise layered modeling and layer-specific bio-ink, and the articular cartilage is obtained by means of an optimized in-situ 3D printing process. The tissue engineering cartilage which is matched with dissection of a defect area and consistent with mechanical and physiological functions of natural cartilage is directly constructed in an articular cavity. Besides, the in-vitro induced differentiation step of the BMSCs is reduced, the risk of cell mutation is reduced, meanwhile, the long-term integration of the repaired tissue and the host cartilage is improved, and the problem that the long-term effectiveness of clinical repair is insufficient is solved.

A suturing apparatus may include a shaft member having a lumen, and a first jaw member and a second jaw member that move between an open configuration and a closed configuration. A distal portion of the first jaw member may be pivotably connected to a distal portion of the second jaw member, and the distal portion of the second jaw member may have a distal opening. The suturing apparatus may further include a needle translates through the lumen of the shaft member and carries a suture, and a retention member in the distal opening of the second jaw member to remove the suture from the needle. The suture may be wrapped around the distal portion of the second jaw member. The suturing apparatus may be included in a suturing system having a suture. The suturing apparatus may be used in a method of repairing tissue.

A method of repairing tissue of a patient secures at least two sutures to two initial points of the patient, and couples sutures to a repair matrix comprising a scaffold portion and an expandable portion. The scaffold portion is configured to integrate over time with the tissue being repaired. The method also expands the expandable portion to urge the repair matrix against the tissue to produce a securing surface, and then secures the at least two sutures to two additional points of the patient. The at least two sutures traverse the securing surface of the repair matrix between the two initial points and the two additional points to secure the repair matrix to the patient.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

A suture assembly comprises a suture anchor, a repair suture, and a shuttle suture. Each suture has a looped end and a tail end. The tail end of the repair suture and the looped end of the shuttle suture extend out one side of the proximal end of the anchor, while the looped end of the repair suture and the tail end of the shuttle suture extend out the opposite side of the anchor. A method of repairing tissue includes implanting the suture anchor into a bone below and to one side of the tissue; passing the tail of the repair suture between a detached tissue and a bone, and then back over the detached tissue and through the loop of the repair suture to create a luggage tag construct before locking the tail of the repair suture against a portion of the suture anchor.

A tissue repair device, system, and method for grasping tissue, such as to repair the tissue (e.g., a defect in tissue), by anchoring a tissue-penetrating arm along a first location along the tissue, moving the anchored tissue-penetrating arm to a second location along the tissue, and grasping tissue at the second location with a tissue-grasping arm. The tissue-penetrating arm remains in a substantially axial straight configuration to facilitate tissue penetration. The tissue-grasping arm is movable towards and away from the tissue-penetrating arm to grasp tissue and hold the grasped tissue between the tissue-grasping arm and the tissue-penetrating arm. The tissue repair device may be left in place holding the tissue in the grasped configuration.

The present disclosure provides a 3D tissue reconstruction implant having a hydrophilic implant surface and consisting of a bioabsorbable material wherein the implant surface is considered hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface, and wherein the implant surface is not hydrophilic when evaluated using an ink test that follows ISO 8296: 2003 and adapts to the 3D surface. Wherein the ink test comprises incubating the implant in a solution consisting of an ink having a surface tension of 72 mN / m and water for 1 minute, and wherein after the implant is incubated in the solution, the ink colored implant surface is an indication of a hydrophilic implant surface. The disclosure also provides the implant for tissue reconstruction, (soft) tissue support, tissue compatibilization and / or implant repair, and the use of the implant for reconstruction, compatibilization and / or repair of tissue and / or support of (soft) tissue, respectively, where the implant is embedded in a patient. The present disclosure further provides a method of manufacturing a tissue reconstruction implant having a hydrophilic implant surface.

Described herein are methods for preparing collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are slurries and implants prepared by such methods.

A system for surgically augmenting tissue of a patient includes a patch configured to integrate with the tissue being repaired, and an expandable member associated with the patch. The patch includes a patch material that progressively integrates with tissue of the patient. In a similar manner, the expandable member is formed of a member material that progressively degrades within the patient at least in part via biological processes of the patient. The expandable member is configured to urge the patch toward the tissue after placement in or on the patient.

The present invention provides a slender anchor for fixing sutures to tissue and a system for deploying the slender anchor. The slender anchor includes a first opening, a second opening, a wire passage extending from the first opening to the second opening, and a first wire embedding space extending axially. The first wire embedding space is connected to the first opening. The distal end of the suture enters the wire passage through the first opening and exits from the second opening to attach to the slender anchor; the extended end of the suture selectively switches between being accommodated in the first wire embedding space and being detached from the first wire embedding space. The slender anchor and system provided by the present invention not only reduce damage to tissue, but also further ensure the effectiveness of tissue repair.

A tissue repair construct, having a repair strand, defining a lumen and having a first end defining an opening of the lumen and a second end opposed to the first end. Further, a shuttle having a loop at a first end and a pull end, opposed to the first end, is engaged through the lumen of the repair strand, entering at the opening and exiting at a broach point through the repair strand, the loop extending out of the opening and the pull end being coincident to the second end of the repair strand. The tissue repair construct forming a tight loop to approximate the tissue extents and repairing the tissue tear.

The invention provides a polypeptide PN-VW22 and application thereof, and belongs to the technical field of polypeptide drugs. The polypeptide PN-VW22 provided by the invention is specifically as follows A1) or A2): A1) an amino acid sequence as shown in SEQ ID NO.1; a2) a fusion protein obtained by connecting a label to the N end or / and C end of A1). The polypeptide has obvious cell proliferation activity and anti-staphylococcus aureus bifunctional activity, and also has a wound repairing effect. The polypeptide is small in molecular weight and stable in structure, can be industrially produced through solid-phase chemical synthesis, can also be industrially applied to preparation of treatment medicines for promoting skin wound repair, and can be used as a candidate polypeptide medicine or a medical beauty product raw material for treating body surface wounds, repairing tissues, burns and skin ulcers, reducing scars and accelerating scar repair.

A method for repairing a tissue. The method can improve the ability of a surgeon to load a suture into a device and unload the suture from the device. A suture retainer can maintain the suture in place with respect to the device.

The invention discloses a traditional Chinese medicine concentrated solution for cell energy activation type scoliosis and a preparation process, and relates to the technical field of traditional Chinese medicine processing. The traditional Chinese medicine concentrated solution is prepared from the following raw materials in parts by weight: 100-140 parts of radix dipsaci, 80-120 parts of cortex eucommiae, 130-170 parts of radix astragali, 60-100 parts of radix angelicae sinensis, 50-70 parts of rhizoma chuanxiong, 60-80 parts of radix angelicae pubescentis, 80-100 parts of fructus lycii, 40-60 parts of radix glycyrrhizae and 15-25 parts of activation auxiliary materials. Himalayan teasel root and eucommia ulmoides in the formula are core components for strengthening muscles and bones and can enhance the toughness of ligaments and tendons around the spine; radix astragali can tonify qi, angelica sinensis can nourish blood, local blood circulation of the spine can be improved, and nutrition is provided for tissue repair; ligusticum wallichii can promote blood circulation to remove meridian obstruction, radix angelicae pubescentis can expel wind-damp, and inflammation and adhesion of soft tissues around The Chinese wolfberry fruits can nourish the liver and the kidney, the licorice roots are matched to harmonize all the medicines, the added activating auxiliary material semen cuscutae extract can activate energy metabolism of osteoblasts and chondrocytes around the spine in a targeted mode, collagen synthesis and calcium deposition are promoted, and tissue damage related to spine malformation is repaired from the cellular level.

An implantable prosthesis for repairing tissue defects includes a layer of repair fabric and a plurality of microtextured grip segments mounted to the repair fabric. The grip segments include a pattern of perforations on a tissue facing surface to promote tissue ingrowth.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

The application relates to a method for inducing mesenchymal stem cells to differentiate into chondroblasts and a composition for promoting regeneration of articular cartilage and application, and belongs to the technical field of biomedical materials. The method for inducing mesenchymal stem cells to differentiate into chondroblasts comprises the following steps: inoculating and culturing on a substrate, wherein the surface of the substrate is provided with a plurality of convex blocks, the plurality of convex blocks are arranged at equal intervals along any extension direction of the surface of the substrate; the height of the convex blocks is not greater than 2 mu m, the ratio of the width of the convex blocks to the interval between adjacent two convex blocks is 1:0.8-1.2, and the interval between the adjacent two convex blocks is not less than 25 mu m; the method further comprises the following steps: spreading mesenchymal stem cells to the surface of the substrate for culture to obtain mesenchymal stem cells with mechanical memory of chondroblast differentiation; and the surface of the substrate comprises the surface of the convex blocks and the surface of the concave parts between the convex blocks. The method can promote the chondroblast differentiation of mesenchymal stem cells, make the subsequently formed repair tissue more close to the original cartilage, and has the advantages of simple operation, high cell survival rate and stable effect.

The application provides a tissue staining method based on antigen repair treatment combined with silver staining, comprising the following steps: a) high-temperature heat repair of a tissue section to be treated with an antigen repair solution, and washing with water after cooling to obtain a repaired tissue section; b) silver staining of the repaired tissue section obtained in step a), dehydration, and then mounting to obtain a stained tissue section. Compared with the prior art, the tissue staining method based on antigen repair treatment combined with silver staining provided by the application adopts specific process steps and conditions to realize overall good interaction: first, the brain tissue is subjected to antigen repair treatment, and then the silver staining technology is adopted, which significantly improves the signal-to-noise ratio of the senile plaque region, and ideal staining effect is obtained, which can effectively improve the detail visibility in pathological detection, help more accurately evaluate the morphology and distribution characteristics of the senile plaque, and has a wide application prospect.

Described herein are collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are systems including collagen implants, methods of preparing collagen slurries and implants, and methods of use thereof.

Described herein are methods for preparing collagen slurries and collagen implants suitable for injection into a repair site to repair a tissue, for example, an anterior cruciate ligament, rotator cuff tendon, and / or a meniscus. Further described are slurries and implants prepared by such methods.

A suturing apparatus may include a shaft member having a lumen, and a first jaw member and a second jaw member that move between an open configuration and a closed configuration. A distal portion of the first jaw member may be pivotably connected to a distal portion of the second jaw member, and the distal portion of the second jaw member may have a distal opening. The suturing apparatus may further include a needle translates through the lumen of the shaft member and carries a suture, and a retention member in the distal opening of the second jaw member to remove the suture from the needle. The suture may be wrapped around the distal portion of the second jaw member. The suturing apparatus may be included in a suturing system having a suture. The suturing apparatus may be used in a method of repairing tissue.

Technologies are disclosed for an implant device that may be configured to repair tissue. The device may include a distal end configured to be connectable to at least a first part of the tissue. The device may include a proximate end configured to be connectable to at least a second part of the tissue. The device may include a substrate configured to form a connection between the first part of the tissue and the second part of the tissue. The device may include a longitudinal axis that may extend between the distal end to the proximate end within the substrate. The device may include at least one preformed channel in the substrate. The device may include at least one suture preloaded at least partially within the at least one channel. The at least one preformed channel may be formed during and / or proximate to a formation of the device.

The present invention is a multi-stage treatment that heals tissue or organ damage (e.g., linear defects, fissures, and fibrillations, as well as focal and large defects) in collagen-rich tissues and organs such as articular cartilage. The present invention includes methods 1) to prime tissues in preparation for treatment, which comprises “melting” the tissue matrix, 2) to add or fill the damaged area with a “melding” agent, comprising of endogenous or exogenous tissue matrix, with or without cells, with or without exogenous biomaterials, and with or without endogenous or exogenous enzymes, such that the melding agent enhances anchoring into the defect for the purpose of integration and / or tissue healing. The Melt-and-Meld process can also be applied in conjunction with any existing treatments of tissue or organ defects.

Methods of repairing composite tissue injuries susceptible to adipocyte infiltration, by applying to the injury an electrospun polymer fiber scaffold comprising biocompatible and bioresorbable polymer fibers that are blended with an amount of a GSK-3 inhibitor that is effective to inhibit the infiltration of adipocytes into the scaffold and tissue. Polymer scaffolds blended with an amount of a GSK-3 inhibitor that is effective to inhibit the infiltration of adipocytes into the scaffold and tissue are also disclosed as are kits containing the scaffolds and stem cells for repairing tissue at the injury site.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

Described herein are methods for repairing tissues (e.g., a meniscus, anterior cruciate ligament, rotator cuff, etc.) using collagen implants suitable. For example, the collagen implants are injected into a repair site to heal the tissue. Further described are collagen slurries, injectable collagen implants and methods of preparation thereof.

The invention relates to the technical field of medical instruments, and discloses a novel implanter suitable for soft tissue repair, which comprises an implanter shell, one side of the implanter shell is provided with a grab handle assembly, the outer side of the grab handle assembly is provided with a combination assembly, one end of the implanter shell is fixedly connected with a sleeve, and the other end of the implanter shell is fixedly connected with a handle. A sleeve is arranged at one end of the implanter shell, a needle head is placed in the sleeve, a plurality of bevel grooves are formed in the outer side of the needle head, a driving assembly is arranged in the implanter shell, and a vibration mechanism is arranged at the other end of the implanter shell; the grab handle assembly comprises a grab handle seat. In the working process of the implanter, reciprocating motion and slight vibration of the needle head are matched with each other, so that the puncturing process is smoother, the operation difficulty is reduced, fibers are brought into muscles through the bevel grooves to form an interlaced structure, an implant and to-be-repaired tissue are firmly combined, the fixing strength is improved, meanwhile, uniform distribution of loads is achieved, and the repairing efficiency is improved. And adverse effects caused by local stress concentration are effectively avoided.

The application relates to the field of medical devices, in particular to a repair system, which at least comprises a double-puncture structure, a catching device and a repair unit connected with the double-puncture structure, the double-puncture structure is used for guiding the repair unit, and the double-puncture structure can pass through the tissue to be repaired back and forth in the repair process; the catching device is arranged on the side of the starting point of the first puncture of the double-puncture structure in the repair process and is abutted against the tissue, so that the tissue for the second puncture of the double-puncture structure is provided with a supporting force, and thus the tissue for the second puncture is provided with the supporting force and the puncture force from the proximal end and the distal end directions respectively, the double-puncture structure can smoothly puncture at the target position, the accuracy of the puncture point is guaranteed, and the catching device is also responsible for catching the repair unit after the second puncture.

A method of repairing tissue of a patient secures at least two sutures to two initial points of the patient, and couples sutures to a repair matrix comprising a scaffold portion and an expandable portion. The scaffold portion is configured to integrate over time with the tissue being repaired. The method also expands the expandable portion to urge the repair matrix against the tissue to produce a securing surface, and then secures the at least two sutures to two additional points of the patient. The at least two sutures traverse the securing surface of the repair matrix between the two initial points and the two additional points to secure the repair matrix to the patient.