65 results about "Soft tissue repair" patented technology

The invention discloses an anisotropic electrostatic spinning patch with ultrasonic response and a preparation method thereof, a fiber membrane with a controllable anisotropic structure is constructed by a biodegradable polymer, antibacterial nanoparticles and a photoinitiator system through a step-by-step directional electrostatic spinning process, so that the mechanical matching property of the fiber membrane is improved; cell growth can be directionally guided and tissue regeneration can be accelerated by combining the piezoelectric material characteristics of the introduced biodegradable polymer with piezoelectric characteristics and electric field stimulation induced by the fiber topological structure; meanwhile, a zwitterionic coating is generated on the surface of the fiber membrane in situ by utilizing a single-sided photocuring technology, and an anti-adhesion function is realized on the single side of the fiber membrane. Furthermore, the soft tissue repair patch which has multiple functions of adjustable mechanical property, infection resistance, adhesion resistance and the like and has better structural mechanical suitability, function integration and tissue regeneration guiding capability is prepared by adopting the anisotropic electrostatic spinning patch with ultrasonic response.

The application belongs to the technical field of medical materials, and discloses a soft tissue repair patch and a preparation method thereof, which comprises the following steps: S1, treating and cleaning animal soft tissue to obtain a first intermediate product; S2, adding the first intermediate product into a reagent to perform freeze-thaw circulation to obtain a second intermediate product; S3, soaking and treating the second intermediate product with an organic solvent and cleaning to obtain a third intermediate product; S4, soaking and treating the third intermediate product with an alkali solution and cleaning to obtain a fourth intermediate product; and S5, soaking and treating the fourth intermediate product with an acid solution, cleaning, drying and sterilizing to obtain the soft tissue repair patch. The application provides a more gentle and friendly decellularization scheme, and the decellularized matrix prepared by using the scheme is more completely decellularized, has no chemical residue, and maintains the natural scaffold structure of collagen.

Provided herein are a method of processing human birth tissue to create a variety of tissue forms that maintain high levels of beneficial compounds and increase tissue availability. Also provided are products made from the processed tissue forms, and application of these products in soft tissue repair and the treatment of wounds.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging of a heart valve in a pre-operative state. The method includes generating a segmented heart valve by segmenting the heart valve of the 3D imaging. The method includes simulating a surgical procedure on the parameterized heart valve. The method includes determining at least one post-operative outcome based on simulating the surgical procedure on the parameterized heart valve. Systems and machine-readable media are also provided.

The invention discloses a preparation method and application of organic-inorganic composite hydrogel with high mechanical adaptability and wet adhesion stability, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by mass: 8.125 percent to 65 percent of calcium phosphate and 35 percent to 91.875 percent of lipoic acid. The bionic wound dressing is beneficial to proliferation and migration of fibroblasts, and more ideal soft tissue regeneration is realized. Experimental results prove that the suture has good cytocompatibility, can quickly promote rat skin defect repair (20 + / -1mm limit skin injury repair time is shortened to 2 weeks), and has a more remarkable healing effect compared with a contrast traditional suture and gauze with an optimal clinical repair effect. The organic-inorganic composite hydrogel with high mechanical adaptability and wet adhesion stability prepared by the invention shows good mechanical properties, also has excellent adhesion, and is beneficial to soft tissue repair.

The invention generally relates to an arrangement for regulated dispensing of suture implant for soft tissue repairs The arrangement includes two-part channel 1 having a first part having an elongated cylindrical sleeve 3 and a second part having an extended lip 5. The extended lip 5 houses one or more suture implants. The elongated cylindrical sleeve 3 is mounted to a detachable head 13 having a slot 15. The two-part channel 1 and the slot 15 accommodate a plunger 17 configured for a horizontal movement. The detachable head 13 further includes one or more stoppers 19 provided at a regular intervals along the slot 15. The arrangement further includes an outer sleeve 13 provided with a plurality of regulating means 25. The regulating means 25 facilitates locking and / or unlocking of the suture 11 while operating the plunger 17 thus enabling regulated dispensing of the suture implant 7.

Dermatological compositions comprising amphiphilic peptides, derivatives or salts thereof are provided. The compositions are particularly useful as dermal fillers and for inducing soft tissue repair and regeneration.

Provided herein are a method of processing human birth tissue to create a variety of tissue forms that maintain high levels of beneficial compounds and increase tissue availability. Also provided are products made from the processed tissue forms, and application of these products in soft tissue repair and the treatment of wounds.

The disclosed composite scaffold provides a highly porous and flexible structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement of the repair or reconstruction-first via scaffold mechanical properties, and subsequently, through newly regenerated functional tissue as the scaffold is resorbed.

The invention discloses a double-layer GBR membrane for promoting soft and hard tissue repair and a preparation method and application thereof, and is applied to the field of medical materials. The double-layer GBR membrane mainly comprises an acellular dermal matrix obtained by decellularizing fetal calfskin and a piezoelectric layer prepared by electrostatic spinning of poly-L-lactic acid and chitosan, and the acellular dermal matrix and the piezoelectric layer are further combined through a polydopamine coating prepared on the surface of the piezoelectric layer. During application, the acellular dermal matrix side faces the soft tissue side, and the piezoelectric layer faces the bone tissue side, so that the acellular dermal matrix skin side which is compact in structure is in contact with the soft tissue to play a barrier role, and the relatively loose piezoelectric layer is in contact with bone defects to play a role in guiding osteoblasts to adhere; functionally, soft tissue repair is promoted through the angiogenesis promoting effect of the acellular dermal matrix and the similarity of the tissue of the acellular dermal matrix, and bone regeneration of a bone defect area is promoted through the piezoelectric osteogenesis and angiogenesis effects of the piezoelectric layer.

Devices, systems, and methods are provided for improving the reliability and surgical completion speed of soft tissue repair procedures. The devices and systems include one or more tissue enhancing constructs including constructs configured to increase a footprint that a suture applies a force to the tissue when the suture is tightened to the tissue. The tissue enhancing constructs may be quickly and easily associated with the repair sutures and may be used in a number of different tissue repair procedures disclosed in the present application. In one exemplary embodiment, one or more constructs are disposed on a suture threader, which may be used to associate the constructs with a repair suture for repairing the soft tissue. The tissue enhancing constructs may include various blocks and patches, as well as other formations. Exemplary methods for making the tissue enhancing constructs are also provided.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

Methods of forming implants suitable for hernia or prolapse repair are provided, the implants including an implantable web including a combination of laid yarns and threading yarns and optionally a substrate. The methods include at least laying one or more laid yarns and threading one or more thread yarns.

The invention discloses a mesenchymal stem cell-derived PDRN and a preparation method thereof, and particularly relates to the technical field of biologication.The method comprises the specific steps that mesenchymal stem cells are collected, Triton X-100, lauryl sodium sulfate, protease, nuclease and guanidine hydrochloride are added, and lysate is obtained; adding lauryl sodium sulfate and sodium chloride into the lysate for salting-out; and carrying out alcohol precipitation with sodium acetate and absolute ethyl alcohol, washing, dehydrating and drying to obtain the PDRN. According to the method, PDRN is extracted from mesenchymal stem cells for the first time, the process is simple, conditions are mild, special environments such as high temperature and strong acid and alkali do not exist, special equipment does not need to be additionally arranged, and large-scale industrial production can be carried out. The prepared mesenchymal stem cell-derived PDRN has an anti-inflammatory function and tissue repair activity, and has a wide application value in the field of soft tissue repair.

The present application belongs to the field of biomedical materials and tissue engineering, and particularly relates to a kind of acellular matrix aerogel repair material and its preparation method and application.Further, the present application relates to the comprehensive preparation method of the material, especially the extremely low immunogenicity acellular process combined with physical, chemical and supercritical fluid technologies, and the unique aerogel forming technology based on supercritical drying.Further, the present application relates to the application of the material, mainly related to soft tissue repair, medical cosmetology, bone / cartilage injury repair field.

The utility model relates to a continuous percussion fixing device, which belongs to the technical field of medical instruments, and comprises a handle, a percussion rod, a percussion rod and a percussion rod, and is characterized in that the handle is provided with a near end and a far end; the sleeve is arranged at the far end of the handle; the percussion assembly comprises a percussion rod and a pushing rod, and the percussion rod and the pushing rod extend into the sleeve from the handle; the driving assembly is arranged in the handle and drives the percussion rod and the pushing rod to move; the at least one implant is positioned in the sleeve and is arranged above the percussion rod; the pushing rod pushes the implants to the far end of the sleeve one by one, and the percussion rod percussion the implant located at the farthest end. By applying the device, the implant can be continuously triggered, the operation of a soft tissue repair operation is simplified, and the operation time is shortened.

Pharmaceutical formulations for topical dental administration or medical (e.g., implant) treatments are disclosed, comprising an effective amount of at least one antimicrobial compound; at least one peroxide source compound; and at least one gel agent. Methods for treating oral anatomical structures are also disclosed. The pharmaceutical formulations and methods of treatment provide oral anatomical benefits to patients, including, for example, reduction or halting of gum recession; reduction or halting of bone recession; reduction or halting of bone loss; reduction or elimination of pain; reduction or elimination of bleeding; reduction or elimination of swelling; enhanced bone regeneration; enhanced soft tissue repair; or combinations thereof.

In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging of a heart valve in a pre-operative state. The method includes generating a segmented heart valve by segmenting the heart valve of the 3D imaging. The method includes simulating a surgical procedure on the parameterized heart valve. The method includes determining at least one post-operative outcome based on simulating the surgical procedure on the parameterized heart valve. Systems and machine-readable media are also provided.

The invention discloses a repair membrane and a preparation method thereof, and relates to the technical field of biological materials, the preparation method comprises the following steps: S1, preparing a polymer membrane; s2, mixing the polymer membrane with a natural polymer material solution, and performing one-way freezing to prepare a through hole structure; and S3, crosslinking the composite membrane of the polymer and the natural polymer material to obtain the repair membrane. According to the repair membrane and the preparation method thereof, the prepared repair membrane takes a high polymer material as a support and a slow degradation inner layer, and takes a cross-linked natural high polymer material with a one-way channel as a guide outer layer. When the composite material is applied to soft tissue repair, such as smooth muscles, blood vessels and tendons, the gelatin one-way channel can guide cells to directionally migrate, adhere, proliferate and arrange, and macromolecules on the inner layer can ensure the matching between the degradation rate of the material and tissue growth, so that the composite material can achieve a better tissue repair effect.

A soft tissue repair graft (500) is described that includes an anti-adhesion layer (502), a structural layer, and a positioning layer. These layers can be distinct or integrated into one substrate. The term "layer" is used to distinguish the function of the tissue repair graft, not to distinguish different layers of material. Different functional layers can include a single plane of material.

A soft tissue repair device. The device includes an inserter having a distal portion, a first anchor carried externally onto the distal portion, a second anchor carried externally onto the distal portion, and a flexible strand coupling the first and second anchors and forming an adjustable knotless loop.

The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include an active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.

The invention belongs to the technical field of preparation of tissue engineering scaffolds, and discloses a flexible composite scaffold based on digital light printing polycaprolactone and a surface coating and a preparation method of the flexible composite scaffold. The flexible composite scaffold with the surface coating comprises a polycaprolactone skeleton, and a silk fibroin film layer and the surface coating which are sequentially positioned on the skeleton from inside to outside, the surface coating is a modified layer of functional molecules, and the functional molecules simultaneously comprise PEGDA, GelMA and RGDMA. According to the invention, a polycaprolactone three-dimensional skeleton printed by a digital light processing technology is used as a configuration support frame, the outer layer of the polycaprolactone three-dimensional skeleton is coated with a silk fibroin film, and the surface of the silk fibroin film is modified with functional molecules, so that the composite scaffold which is programmable in shape, adjustable in mechanical property and has biological activity is realized through a collaborative construction mode; the method is suitable for various tissue engineering application fields such as bone repair, valve regeneration and soft tissue repair, and has excellent application prospect and popularization value.

1. Name of the product in this design: Ultrasonic Electrical Stimulator. 2. Purpose of this design: For the treatment of pain, muscle function stimulation and recovery, soft tissue repair, etc. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the key design points: Design 1 3D view. 5. Design 1 is designated as the basic design.

The invention provides an integrated orthopedic fixation system that enhances precision, reproducibility, and biomechanical stability in bone and soft-tissue repair. In one aspect, a loop suture includes one or more integrally formed loops spaced along its length, each functioning as a selectable tensioning point that enables a surgeon to incrementally "dial in" soft-tissue tension without manual knot-tying. In another aspect, a bone plate with a slip-knot pathway incorporates strategically oriented holes, tunnels, and slots configured to guide a suture in a unidirectional, self-locking manner, forming a stable, knotless construct. In a further aspect, a lateral ulna plate is anatomically contoured for placement on the lateral surface of the proximal ulna and integrates the slip-knot suture pathway to provide rigid fracture fixation while minimizing hardware prominence and optimizing triceps-tendon tension control. The combined system allows precise, repeatable, and adjustable fixation of bone and soft tissue using a single low-profile implant platform.

An orthopedic button assembly for soft tissue repair or bone repair using a method for securing sutures or fixation members in a knotless manner. The orthopedic button assembly is designed in a manner to as to not rely on an additional component to perform the locking. The orthopedic button assembly of the present disclosure includes the ability to optimally tension the repair by pulling the tensionable fixation members (e.g. sutures) in the tensioning direction and prevent slippage of the tensionable fixation members in the opposite direction by capturing the tensionable fixation members in a manner such that pulling on the tensionable fixation members in the direction opposite of the tensioning direction (e.g., if connected tissue or bone were to attempt to “pull away” from the button assembly under tension) actually increases the tension, resulting in a tighter locking interface to increase the security of the repair.

The invention discloses porous polycaprolactone microspheres for tissue filling and a preparation method of the porous polycaprolactone microspheres, and relates to the field of biomedical materials. The microsphere is composed of polycaprolactone, the diameter of the microsphere is 40-70 [mu] m, the dispersion coefficient of the microsphere is less than 5%, the porosity of the microsphere is 55-85%, and the surface of the microsphere is provided with a uniform open pore structure formed by tridecane. According to the preparation method, a microfluidic technology is adopted, a tridecane-containing polycaprolactone dichloromethane solution is taken as a dispersion phase, a polyvinyl alcohol aqueous solution is taken as a continuous phase, an oil-in-water emulsion is formed through microchannel shearing, and curing, washing and freeze-drying are performed to obtain the tridecane-containing polycaprolactone / polyvinyl alcohol composite material. The microspheres disclosed by the invention have excellent monodispersity and a porous structure, and can remarkably promote fibroblast proliferation and collagen secretion and induce moderate inflammatory response to activate tissue regeneration. The process is simple and controllable, and the obtained microspheres have injectability and a tissue repair promoting function and have application prospects in the field of soft tissue repair.

The invention relates to the technical field of soft tissue repair materials, in particular to a soft tissue repair material and a preparation method and application thereof. The invention relates to a polyurethane elastomer, which is prepared from an alternating block copolymer, the alternating block copolymer is obtained by reaction of polyester polyol, polyether polyol and diisocyanate, the use amount of diisocyanate accounts for 4-12% of the total mass of polyether polyol, polyester polyol and diisocyanate, and the use amount of polyurethane accounts for 1-5% of the total mass of polyether polyol, polyester polyol and diisocyanate. The diisocyanate is at least one or a combination of lysine diisocyanate and 1, 4-butane diisocyanate. The soft tissue repair material has an excellent repair effect and can be completely biodegraded, a degradation product cannot cause adverse reaction in vivo, and the soft tissue repair material is free of immunogenicity, has good biocompatibility and mechanical performance and can meet the core requirement of the soft tissue repair material.