114 results about "Soft tissue repair" patented technology

The invention discloses an anisotropic electrostatic spinning patch with ultrasonic response and a preparation method thereof, a fiber membrane with a controllable anisotropic structure is constructed by a biodegradable polymer, antibacterial nanoparticles and a photoinitiator system through a step-by-step directional electrostatic spinning process, so that the mechanical matching property of the fiber membrane is improved; cell growth can be directionally guided and tissue regeneration can be accelerated by combining the piezoelectric material characteristics of the introduced biodegradable polymer with piezoelectric characteristics and electric field stimulation induced by the fiber topological structure; meanwhile, a zwitterionic coating is generated on the surface of the fiber membrane in situ by utilizing a single-sided photocuring technology, and an anti-adhesion function is realized on the single side of the fiber membrane. Furthermore, the soft tissue repair patch which has multiple functions of adjustable mechanical property, infection resistance, adhesion resistance and the like and has better structural mechanical suitability, function integration and tissue regeneration guiding capability is prepared by adopting the anisotropic electrostatic spinning patch with ultrasonic response.

The invention relates to the technical field of biomedical materials, and discloses a soft tissue repairing and wrinkle filling material based on N-vinylpyrrolidone and polyethylene glycol diacrylate mixed polymer hydrogel and a preparation process of the soft tissue repairing and wrinkle filling material based on N-vinylpyrrolidone and polyethylene glycol diacrylate mixed polymer hydrogel. Polyethylene glycol diacrylate; an initiator; a solvent; the preparation process comprises the following steps: S1, mixing and dissolving all materials to form a pre-polymerization solution; s2, forming hydrogel through photopolymerization and thermal polymerization; s3, carrying out dialysis on the obtained hydrogel; and S4, performing freeze drying on the dialyzed hydrogel, and performing sterilization treatment. By adopting a light and heat dual initiation system, the purpose of realizing rapid polymerization under a mild condition is achieved. Compared with a single initiation system in the prior art, the technology solves the problems of slow polymerization rate and harsh reaction conditions, so that the polymerization process is more efficient and safer.

The application belongs to the technical field of medical materials, and discloses a soft tissue repair patch and a preparation method thereof, which comprises the following steps: S1, treating and cleaning animal soft tissue to obtain a first intermediate product; S2, adding the first intermediate product into a reagent to perform freeze-thaw circulation to obtain a second intermediate product; S3, soaking and treating the second intermediate product with an organic solvent and cleaning to obtain a third intermediate product; S4, soaking and treating the third intermediate product with an alkali solution and cleaning to obtain a fourth intermediate product; and S5, soaking and treating the fourth intermediate product with an acid solution, cleaning, drying and sterilizing to obtain the soft tissue repair patch. The application provides a more gentle and friendly decellularization scheme, and the decellularized matrix prepared by using the scheme is more completely decellularized, has no chemical residue, and maintains the natural scaffold structure of collagen.

The present disclosure describes membranes suitable for use in soft tissue repair applications that are composed of fibrous and highly porous biodegradable materials fabricated using electrospinning and that may be surface-modified with plasma treatment or other suitable methods of surface modification. The disclosed membranes have a high surface area to volume ratio. In some implementations, use of the disclosed membranes provides a barrier that prevents the migration of soft tissue cells but is permeable to small molecules such as nutritional substances and medications. In other implementations, use of the disclosed membranes provides a scaffold to facilitate soft tissue repair by providing a suitable environment for cellular infiltration and interaction to promote tissue regeneration. Methods of fabricating the disclosed resorbable membranes for soft tissue repair applications using electrospinning are also disclosed. The disclosed membranes may have precisely tuned physical, chemical, and mechanical properties optimized for various soft tissue repair applications.

A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.

Provided are a detachable robot for open fracture reduction and fixation and a method of use. The detachable robot for reduction and fixation comprises a first assembly, a second assembly, and a brace assembly. The first assembly and the second assembly are detachably connected to form an accommodation space for accommodating a fractured site. The brace assembly is located in the accommodation space and detachably connected with the first assembly. The brace assembly is used for connecting bones on the two sides of the fractured bone. The present invention features compactness, ease of operation, and improved surgery quality and efficiency. The detachable and open-close structure can meet the requirements of treating open fractures at different positions. The present invention also enables the integrated operations of reduction and fixation to ensure a more effective traction and alignment in open fracture reduction and fixing operation, thus effectively ensuring good vision of the doctor in various soft tissue repair operations.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention discloses an implantable acellular matrix material and a preparation method thereof, and belongs to the field of biomedical materials. According to the method, natural animal tissues (such as pericardium, achilles tendon or small intestine submucosa) are used as raw materials, a low-temperature chemical combined decellularization treatment technology is adopted, and the method comprises the multi-step synergistic process of pre-cooling soaking balancing, low-temperature enzymolysis, low-concentration surfactant gradient permeation cleaning, low-temperature nuclease degradation, non-crosslinking sterilization and the like. Under the condition that the treatment temperature is strictly kept at 0-8 DEG C, cell components and genetic materials (the residual DNA content is 1t, and the dry weight is 8 ng / mg) are efficiently removed, and meanwhile the natural three-dimensional fine structure of an extracellular matrix (ECM), the integrity of collagen fibrils and key bioactive components (such as glycosaminoglycans (GAGs)) are reserved to the maximum extent. The host immunological rejection reaction of the obtained material is remarkably reduced, host cell ingrowth, vascularization and tissue function reconstruction can be effectively promoted after implantation, and the material is suitable for high-end implantation scenes such as soft tissue repair and regenerative medical stents.

Improved allografts having controlled and consistent properties and useful for soft tissue repair, including breast reconstruction, and other surgical procedures, are disclosed. In one embodiment, an improved acellular dermal matrix (ADM) is produced from a skin sample, where the ADM consists essentially of a single dermal tissue type (e.g., papillary or reticular) and comprises a collagen matrix having substantially uniform density and porosity. In another embodiment, two ADMs are produced from the same dermal tissue type (e.g., papillary or reticular) of the same skin sample, each of which consists essentially of reticular dermis, and comprises a collagen matrix having substantially uniform density and porosity. All such improved ADMs are suitable for use in breast reconstruction and other tissue repair and modification surgery procedures.

The invention discloses polycaprolactone / acellular extracellular matrix composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological tissue engineering. The amino-modified polycaprolactone nanofiber and the fat acellular matrix are compounded in proportion for the first time, genipin is used as a cross-linking agent of the composite hydrogel, and the hydrogel of an injectable composite material is prepared. The crosslinking degree, the gelation time, the degradation performance, the swelling performance and the mechanical performance of the composite hydrogel with different proportions are studied, and the influence of the composite hydrogel on angiogenesis and fat regeneration in vivo is studied. According to the novel injectable composite hydrogel disclosed by the invention, the 1% PCL / DAT group composite hydrogel has good adipogenesis and vascularization effects, and a new thought is provided for subsequent soft tissue repair and regeneration research.

Provided herein are a method of processing human birth tissue to create a variety of tissue forms that maintain high levels of beneficial compounds and increase tissue availability. Also provided are products made from the processed tissue forms, and application of these products in soft tissue repair and the treatment of wounds.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

The invention belongs to the field of soft tissue repair, and particularly relates to injectable monodisperse composite microspheres for tissue filling and regeneration, composite microsphere hydrogel as well as a preparation method and application of the composite microsphere hydrogel. The invention aims to provide a composite microsphere capable of simultaneously meeting instant filling and long-term effectiveness, the composite microsphere is prepared by shearing an internal phase solution, an intermediate phase solution and an external phase solution into an emulsion and then curing by adopting a microfluidic technology, a core material of the composite microsphere is poly-L-lactic acid and the like, a shell layer is hyaluronic acid, and the composite microsphere is prepared by adopting a micro-fluidic technology. The obtained composite microspheres are uniform in morphology, size and height, and the sizes of the core layer and the shell layer are controllable. The shell layer is made of hyaluronic acid, tissue occupation can be achieved, instant filling is met, the core material in the composite microsphere is gradually released, growth of subcutaneous collagenous fibers is stimulated, the filled part is gradually replaced by dermal fibers and collagen, the degradation period of the material of the internal microsphere is generally 9-12 months, the effect is more natural, and no false face feeling exists; and the inflammatory response is smaller.

In certain aspects of the present disclosure, a computer-implemented method includes receiving a 3D imaging of a heart valve in a pre-operative state. The method includes generating a segmented heart valve by segmenting the heart valve of the 3D imaging. The method includes simulating a surgical procedure on the parameterized heart valve. The method includes determining at least one post-operative outcome based on simulating the surgical procedure on the parameterized heart valve. Systems and machine-readable media are also provided.

The invention discloses a preparation method and application of organic-inorganic composite hydrogel with high mechanical adaptability and wet adhesion stability, and belongs to the technical field of biomedical tissue engineering. The hydrogel is prepared from the following components in percentage by mass: 8.125 percent to 65 percent of calcium phosphate and 35 percent to 91.875 percent of lipoic acid. The bionic wound dressing is beneficial to proliferation and migration of fibroblasts, and more ideal soft tissue regeneration is realized. Experimental results prove that the suture has good cytocompatibility, can quickly promote rat skin defect repair (20 + / -1mm limit skin injury repair time is shortened to 2 weeks), and has a more remarkable healing effect compared with a contrast traditional suture and gauze with an optimal clinical repair effect. The organic-inorganic composite hydrogel with high mechanical adaptability and wet adhesion stability prepared by the invention shows good mechanical properties, also has excellent adhesion, and is beneficial to soft tissue repair.

The invention generally relates to an arrangement for regulated dispensing of suture implant for soft tissue repairs The arrangement includes two-part channel 1 having a first part having an elongated cylindrical sleeve 3 and a second part having an extended lip 5. The extended lip 5 houses one or more suture implants. The elongated cylindrical sleeve 3 is mounted to a detachable head 13 having a slot 15. The two-part channel 1 and the slot 15 accommodate a plunger 17 configured for a horizontal movement. The detachable head 13 further includes one or more stoppers 19 provided at a regular intervals along the slot 15. The arrangement further includes an outer sleeve 13 provided with a plurality of regulating means 25. The regulating means 25 facilitates locking and / or unlocking of the suture 11 while operating the plunger 17 thus enabling regulated dispensing of the suture implant 7.

Dermatological compositions comprising amphiphilic peptides, derivatives or salts thereof are provided. The compositions are particularly useful as dermal fillers and for inducing soft tissue repair and regeneration.

Provided herein are a method of processing human birth tissue to create a variety of tissue forms that maintain high levels of beneficial compounds and increase tissue availability. Also provided are products made from the processed tissue forms, and application of these products in soft tissue repair and the treatment of wounds.

The disclosed composite scaffold provides a highly porous and flexible structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement of the repair or reconstruction-first via scaffold mechanical properties, and subsequently, through newly regenerated functional tissue as the scaffold is resorbed.

The invention discloses a double-layer GBR membrane for promoting soft and hard tissue repair and a preparation method and application thereof, and is applied to the field of medical materials. The double-layer GBR membrane mainly comprises an acellular dermal matrix obtained by decellularizing fetal calfskin and a piezoelectric layer prepared by electrostatic spinning of poly-L-lactic acid and chitosan, and the acellular dermal matrix and the piezoelectric layer are further combined through a polydopamine coating prepared on the surface of the piezoelectric layer. During application, the acellular dermal matrix side faces the soft tissue side, and the piezoelectric layer faces the bone tissue side, so that the acellular dermal matrix skin side which is compact in structure is in contact with the soft tissue to play a barrier role, and the relatively loose piezoelectric layer is in contact with bone defects to play a role in guiding osteoblasts to adhere; functionally, soft tissue repair is promoted through the angiogenesis promoting effect of the acellular dermal matrix and the similarity of the tissue of the acellular dermal matrix, and bone regeneration of a bone defect area is promoted through the piezoelectric osteogenesis and angiogenesis effects of the piezoelectric layer.

Devices, systems, and methods are provided for improving the reliability and surgical completion speed of soft tissue repair procedures. The devices and systems include one or more tissue enhancing constructs including constructs configured to increase a footprint that a suture applies a force to the tissue when the suture is tightened to the tissue. The tissue enhancing constructs may be quickly and easily associated with the repair sutures and may be used in a number of different tissue repair procedures disclosed in the present application. In one exemplary embodiment, one or more constructs are disposed on a suture threader, which may be used to associate the constructs with a repair suture for repairing the soft tissue. The tissue enhancing constructs may include various blocks and patches, as well as other formations. Exemplary methods for making the tissue enhancing constructs are also provided.

Particles of non-woven graft materials for use in specialized surgical procedures such as soft tissue repair and wound management procedures, methods for making the powder, and methods for repairing tissue such as neurological tissue using the powder are disclosed. The particles can advantageously be used to fill irregular shaped areas or can be used in conjunction with non-woven graft materials.

Surgical constructs and methods are provided for securing soft tissue to bone. One exemplary embodiment of a construct is formed from a suture filament and includes two terminal ends of filament and an intermediate portion disposed along at least a portion of a length extending between the terminal ends. The construct can have a first terminal end that is the first terminal end of the filament, and a second terminal end that includes a loop. The loop can be formed by disposing the second terminal end of the filament within a volume of a portion of the intermediate portion of the filament. In some disclosed methods, both terminal ends of the filament can be passed through tissue when performing soft tissue repairs. Various other embodiments of constructs and methods are provided, including constructs having two or more filaments associated with an anchor and methods of using such constructs.

Methods of forming implants suitable for hernia or prolapse repair are provided, the implants including an implantable web including a combination of laid yarns and threading yarns and optionally a substrate. The methods include at least laying one or more laid yarns and threading one or more thread yarns.

The invention discloses a mesenchymal stem cell-derived PDRN and a preparation method thereof, and particularly relates to the technical field of biologication.The method comprises the specific steps that mesenchymal stem cells are collected, Triton X-100, lauryl sodium sulfate, protease, nuclease and guanidine hydrochloride are added, and lysate is obtained; adding lauryl sodium sulfate and sodium chloride into the lysate for salting-out; and carrying out alcohol precipitation with sodium acetate and absolute ethyl alcohol, washing, dehydrating and drying to obtain the PDRN. According to the method, PDRN is extracted from mesenchymal stem cells for the first time, the process is simple, conditions are mild, special environments such as high temperature and strong acid and alkali do not exist, special equipment does not need to be additionally arranged, and large-scale industrial production can be carried out. The prepared mesenchymal stem cell-derived PDRN has an anti-inflammatory function and tissue repair activity, and has a wide application value in the field of soft tissue repair.

An orthopedic button assembly providing the ability to perform a soft tissue repair or bone repair using a method for securing sutures or fixation members in a knotless manner is described. The orthopedic button assembly of the present disclosure is designed in a manner to as to not rely on an additional component to perform the locking. The orthopedic button assembly of the present disclosure includes the ability to optimally tension the repair by pulling the tensionable fixation members (e.g. sutures) in the tensioning direction and prevent slippage of the tensionable fixation members in the opposite direction by capturing the tensionable fixation members in a manner such that pulling on the tensionable fixation members in the direction opposite of the tensioning direction (e.g., if connected tissue or bone were to attempt to “pull away” from the button assembly under tension) actually increases the tension, resulting in a tighter locking interface to increase the security of the repair.

The present application belongs to the field of biomedical materials and tissue engineering, and particularly relates to a kind of acellular matrix aerogel repair material and its preparation method and application.Further, the present application relates to the comprehensive preparation method of the material, especially the extremely low immunogenicity acellular process combined with physical, chemical and supercritical fluid technologies, and the unique aerogel forming technology based on supercritical drying.Further, the present application relates to the application of the material, mainly related to soft tissue repair, medical cosmetology, bone / cartilage injury repair field.

The utility model relates to a continuous percussion fixing device, which belongs to the technical field of medical instruments, and comprises a handle, a percussion rod, a percussion rod and a percussion rod, and is characterized in that the handle is provided with a near end and a far end; the sleeve is arranged at the far end of the handle; the percussion assembly comprises a percussion rod and a pushing rod, and the percussion rod and the pushing rod extend into the sleeve from the handle; the driving assembly is arranged in the handle and drives the percussion rod and the pushing rod to move; the at least one implant is positioned in the sleeve and is arranged above the percussion rod; the pushing rod pushes the implants to the far end of the sleeve one by one, and the percussion rod percussion the implant located at the farthest end. By applying the device, the implant can be continuously triggered, the operation of a soft tissue repair operation is simplified, and the operation time is shortened.

A fibrous tissue repair device includes first and second tubular anchors having corresponding longitudinal passages. The tissue repair device includes corresponding first and second inserters. Each inserter has a shaft with a distal portion received in the longitudinal passage of the corresponding tubular anchor. A flexible strand couples the first and second anchors.

Soft tissue repair grafts are described comprising an anti-adhesion layer, a structural layer, and a localization layer. These layers may be distinct or integrated into one substrate. The term layer is used to distinguish tissue repair graft functionality rather than distinct material layers. The distinct layers of functionality may comprise a single plane of a substance.