36 results about "Dermal Fillers" patented technology

The present invention provides a composition for reducing or eliminating vascular occlusion caused by hyaluronic acid soft tissue dermal fillers. [Solution] This disclosure provides for compositions comprising hyaluronidase, apparatus for housing such compositions, and methods and uses of such compositions and apparatus for reducing or eliminating hyaluronic acid-induced blockages in one or more blood vessels supplying an individual's eye; methods and uses of such compositions and apparatus for reducing or inhibiting vascular occlusion of an individual's eye; and methods and uses of such compositions and apparatus for reducing or inhibiting hyaluronic acid-induced vision loss in an individual.

Provided herewith is a needle for delivering dermal filler thread to a wrinkle in a patient. The needle can also be used to deliver the thread to a patient for the purposes of facial contouring. The needle comprises a coupler for attaching the thread to the needle and also a trocar to ease delivery through the skin.

Introduced here are novel techniques and tools for augmenting the lips through superficial linear injection of dermal fillers. At a high level, these techniques are representative of a two-step approach to augmentation. In the first stage, an implement that is appropriately positioned inside a lip can be moved sideways—an action referred to as a “side push.” In the second stage, dermal filler can be ejected from the implement so as to fill the resulting void. These techniques can be used by healthcare professionals to reshape the lips for medical or aesthetic purposes. These techniques were developed in an attempt to permit augmentation of the outer surface of a lip so as to increase its volume by expanding sideways while turning the lip outward. Presented here are also tools to improve the accuracy of injection. With these techniques, the desired result-namely, a plumper lip—may be readily and consistently achievable.

Dermatological compositions comprising amphiphilic peptides, derivatives or salts thereof are provided. The compositions are particularly useful as dermal fillers and for inducing soft tissue repair and regeneration.

The present disclosure provides a method for reducing, removing, or dispersing a dermal filler aggregate in a subject. The method includes contacting a target area of the subject’s skin with a device configured to apply vibrational or mechanical energy, and applying vibrational energy to the target area for a duration sufficient to facilitate reduction, removal, or dispersion of the dermal filler aggregate. The vibrational energy may be applied while the device is held stationary over the aggregate or moved across the target area in vertical, horizontal, circular, or sweeping motions. In certain embodiments, the device is configured to contact the skin, and visible light is optionally applied during treatment. Application of vibrational energy promotes mechanical disruption and redistribution of dermal filler material within the surrounding tissue, thereby reducing the palpability or appearance of filler nodules, clumps, or irregularities.

The present invention relates to a dispersion comprising acellular dermal matrix microparticles, a filler comprising the same, and uses thereof. More specifically, the present invention relates to a filler comprising a dispersion containing acellular dermal matrix microparticles obtained by supercritical fluid extraction and high pressure dispersion operations, and a method for preparing the same. The acellular dermal filler according to the present invention has excellent biological stability and biocompatibility, and extracellular matrix components such as collagen and elastin are significantly preserved therein. In addition, the filling agent also shows excellent biochemical stability, the pH value or the collagen content and the elastin content are kept unchanged in the storage process, and the filling agent also shows physical stability and can continuously maintain injectability. Therefore, the acellular dermal filler can be effectively used as an injectable filler for repair or volume expansion of soft tissue and reduction of wrinkles in the field of plastic and regenerative medicine.

The invention discloses a polyester material composite microsphere, a leather filling agent and a preparation method, and the prepared filling agent forms controllable sequential degradation in vivo by controlling the compounding proportion and preparation process parameters of polyester materials with different molecular weights; the problems of microsphere aggregation and nodule reaction in the use process of the existing filling agent are solved, meanwhile, local accumulation of acidic degradation products is remarkably reduced, and inflammatory reaction is avoided.

A method for filtering or removing agglomerates of individual particles from a viscous substance, such as a dermal filler formulation, is provided. The method involves loading the viscous substance into an extrusion system with a sieve or filter located inside, outside, or adjacent to the system, or external thereto. The substance is extruded through the filter / sieve, which filters / removes agglomerates present in the viscous substance due to their larger size. Alternatively, pressure-based filtration causes the separation of individual particles, which causes the agglomerates to break down, allowing the viscous substance to pass through the extrusion system without clogging issues. The filtered viscous substance is suitable for administration to a patient. The present invention also describes a device for implementing the proposed pressure-based filtration technique.

Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

1. Name of the product in this design: Vial (facial filler). 2. Purpose of this design: For packaging pharmaceuticals. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key features: the front view.

A method of filtering or removing agglomerations of individual particles from a viscous material such as a dermal filler formulation is provided. The method involves filling the viscous material in an extrusion system comprising a sieve or filter placed inside, outside, adjacent to or outside the system. The material is forced to pass through the filter / sieve which causes filtration / removal of the agglomerates present in the viscous material owing to its larger size. Alternatively, the pressure-based filtration cause separation of the individual particles causing breakdown of the agglomerates, thereby allowing the viscous material to pass through the extrusion system without any occlusion problems. The filtered viscous material is suitable for administration to the patients. The invention also describes devices to carry out the proposed pressure-filtration technique.

The current invention involves a method of mixing POP with a polysaccharide to obtain an improved injectable tissue matrix. POP is a partially ordered polypeptide and a polysaccharide, in this instance, comprises at least one glycosaminoglycan. The invention involves mixing these compounds in an injectable tissue matrix to increase volume retention, vascularization, and remodeling immune response, all of which are characteristics that would be useful for an injectable dermal filler, and in plastic and reconstructive procedures.

Syringe attachments and syringes have particular suitability to the precision dispensing of small amounts of high viscosity materials, such as dermal fillers. An attachment may include a main body having an assist feature that includes a wheel and pinion gears on each side of the wheel which engage respective racks on the syringe body. A mechanical advantage may be provided to the user as the wheel is rotated relative to the syringe body and racks. Syringes and attachments may include precision position indicators viewed from multiple positions to enable a user to determine plunger position and the amount of dispensed contents with precision. An alternative configuration attachment may be slidably secured to a syringe to permit a user to operation the syringe from a lateral position using sliding movement of the thumb and fingers of one hand, for example. This configuration may be particularly suitable for self-administered insulin injections.

Provided herein are dermal fillers including decellularized plant or fungal tissue from which cellular materials and nucleic acids of the tissue are removed; as well as methods and uses thereof for cosmetic and / or reconstructive applications. Also provided are methods for preparing such dermal fillers, and dermal filler kits.

The invention provides a composition based on HA and HAp in the field of soft tissue filling and a preparation method thereof. Optionally, a dermal filler is used to increase facial tissue uplift by adding a volume to the facial tissue, correcting wrinkles and laws, and restoring the smooth appearance of the face. Optionally, the dermal filler includes an uncrosslinked or crosslinked HA that is chemically bonded to the HAp.

A process is provided for manufacturing injectable hyaluronic acid (HA) dermal fillers consisting of cross-linking high molecular weight (MW) HA with the cross-linking agent 1,4-butanediol diglycidyl ether (BDDE) with a relatively small amount of BDDE by reaction in a planetary centrifuge under vacuum or with a relatively large amount of BDDE with mechanical agitation for the reaction and an ultra-turrax device for particle sizing. The processes generate HA hydrogels with only one degree of cross-linking for use in manufacturing HA dermal fillers with varying concentrations of HA and combinations of particle sizes. HA dermal fillers are based on particle balance technology (PBT), in which hydrogels with different physico-chemical and rheological properties are obtained. They can be used in medical surgery and orthopaedic applications, as well as for dermal filling, body and facial contouring, volumisation and skin hydration.

The present invention provides a dermal filler and a preparation method thereof, relating to the field of biomedicine. The dermal filler comprises a filler solution and polylactic acid / hydroxyethyl cellulose microspheres dispersed in the filler solution; the filler solution comprises a suspending dispersant and a buffer salt; and the polylactic acid / hydroxyethyl cellulose microspheres comprise polylactic acid microspheres and hydroxyethyl cellulose coated on the surface of the polylactic acid microspheres. The dermal filler provided by the present invention, which comprises polylactic acid / hydroxyethyl cellulose microspheres as its primary component and supplemented with a filler solution, exhibits excellent biocompatibility and can provide a long-lasting filling effect, thus achieving efficacy without the need for multiple injections and being easy to use.

A device comprising: a sleeve body defining an inner bore and terminating at a distal opening; a hollow microneedle defining a lumen and terminating at a distal tip, where the microneedle is configured to be reciprocally displaceable within the bore such that the tip extends and retracts through the distal opening; and a plunger having a shaft operable to advance a seal along the lumen to deliver an amount of a specified composition within the lumen along the lumen and through an outlet at a distal portion of the microneedle.

The present invention relates to a PLA microparticle composition for a dermal filler and a production method therefor. Provided are a PLA microparticle composition for a dermal filler, the composition being uniformly produced through micro-spraying by a chemical-resistant spray equipped with a brass nozzle, and a production method for PLA microparticles for a dermal filler, the method exhibiting a high yield, and thus same may be utilized in the skin plastic surgery filler production industry by having a cheaper and simpler production process.

1. Name of the designed product: packaging box set (facial filler). 2. Use of the designed product: for packaging products. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view of set 1. 5. Other circumstances needing explanation: set 1 is an outer box, and set 2 is an inner bottle.

This invention relates to an injectable dermal filler formulation for providing improved and uniform plumping and filling effects. Specifically, the formulation comprises a combination of hyaluronic acid and polyorthoesters and can be used for cosmetic purposes.

The present invention relates to a dispersion solution containing acellular dermal matrix microparticles, a filler comprising same, and use thereof. More specifically, the present invention relates to: a filler comprising a dispersion solution containing acellular dermal matrix microparticles obtained through supercritical fluid extraction and high-pressure dispersion; and a preparation method therefor. The acellular dermal filler according to the present invention has excellent biostability and biocompatibility, and extracellular matrix components such as collagen and elastin are remarkably preserved therein. In addition, excellent biochemical stability without changes in pH during storage or changes in the amounts of collagen and elastin is exhibited, and physical stability in which injectability is continuously maintained is also exhibited. Therefore, the acellular dermal filler can be effectively used as an injectable filler for repair or volume expansion of soft tissue and wrinkle reduction in the plastic and regenerative medicine fields.

Compositions based on HA and HAp in the field of soft tissue fillers, and a method of manufacturing thereof. Optionally, the dermal fillers are useful for enhancing facial tissue augmentation by adding volume to facial tissue, correct wrinkles and folds and restore a smooth appearance to the face. Optionally, the dermal filler comprises uncrosslinked or crosslinked HA chemically bonded to HAp.

The present invention relates to new hyaluronic acid derivatives conjugated with molecules of natural origin endowed with anti-inflammatory and / or antioxidant properties and processes for manufacturing the same. The covalent link of these bioactive molecules to hyaluronic acids and the degree of reticulation with the same affords peculiar characteristics in term of controlled release of the bioactive molecules and of viscoelastic properties and stabilize the obtained hyaluronic derivatives to the chemical and to the enzymatic degradation. These new hyaluronic acid derivatives are useful for the preparation of injectable dermal filler compositions effective as soft tissue fillers, like dermal and subdermal fillers.

The present invention generally relates to the field of dermal fillers, and more specifically to a method for preparing a microparticles comprising crosslinked sulfated glycosaminoglycan (GAG) polysaccharide moieties. The present invention further relates to microparticles obtainable by said method and their use, as well as compositions comprising said microparticles and uses thereof.

HA and HAp-based compositions and methods for producing them in the field of soft tissue fillers. Optionally, the transdermal filler is useful for enhancing facial tissue augmentation by adding volume to facial tissue, correcting wrinkles and wrinkle folds, and restoring a smooth facial appearance. Optionally, the transdermal filler comprises uncrosslinked or crosslinked HA chemically bonded to HAp. [Selected Figure] Figure 2

Provided herein are systems and methods for delivering a dermal filler formulation to a tissue site, the dermal filler formulation comprising a hydrogel annealed in vivo to form a porous covalently stabilized scaffold under conditions sufficient to form a cellular matrix within the porous covalently stabilized scaffold, thereby permanently filling at least a portion of the tissue site of the subject with the cell matrix while minimizing foreign matter response of the subject.

The present disclosure provides dermal fillers comprising hyaluronic acid-based hydrogels. The hydrogels are coacervates formed through ionic interactions between anionic polysaccharides, such as hyaluronic acid, and cationic polysaccharides, such as chitosan. The dermal fillers are useful for augmenting soft tissues, reducing soft tissue defects and improving skin quality.