Composition, in an aqueous medium, including at least one hyaluronic acid and at least one sucrose octasulphate water-soluble salt

A technology of sucrose octasulfate and water-soluble salt, which is applied in the direction of drug combination, medical preparations containing active ingredients, allergic diseases, etc., to achieve the effect of high persistence and long half-life

Active Publication Date: 2015-03-04
LABES VIVACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0034] In the present invention, the applicant of our company aims to solve the problem of decomposition of hyaluronic acid-containing compositions caused by hyaluronidase by adding a water-soluble salt of sucrose octasulfate, while maintaining these com

Method used

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  • Composition, in an aqueous medium, including at least one hyaluronic acid and at least one sucrose octasulphate water-soluble salt
  • Composition, in an aqueous medium, including at least one hyaluronic acid and at least one sucrose octasulphate water-soluble salt
  • Composition, in an aqueous medium, including at least one hyaluronic acid and at least one sucrose octasulphate water-soluble salt

Examples

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Effect test

Embodiment 1

[0157] This example illustrates a composition according to the invention comprising non-crosslinked hyaluronic acid and potassium sucrose octasulfate.

[0158] Injectable grade sodium hyaluronate (NaHA) fibers (1 g; molecular weight: about 2.7 MDa) were weighed in a container. Phosphate buffered saline solution (32.3 g) was added, and the whole material was homogenized with a spatula for about 1 hour at room temperature and an atmospheric pressure of 900 mmHg.

[0159] The NaHA concentration of the thus obtained non-crosslinked NaHA hydrogel was about 30 mg / g.

[0160] Potassium sucrose octasulfate (KSOS) (60mg, 4.7×10 -5 mol) was dissolved in a phosphate buffer solution (19.94 g) to obtain an aqueous solution of potassium sucrose octasulfate with a concentration of 3 mg / g.

[0161] Dilute the NaHA hydrogel obtained in the preceding steps by adding the aqueous solution of potassium sucrose octasulfate prepared above. The composition thus obtained is subsequently homogenized...

Embodiment 2

[0166] This example illustrates a composition according to the invention comprising cross-linked hyaluronic acid and potassium sucrose octasulfate.

[0167] According to the cross-linking method described in WO 2009 / 071697 (Example 1, Part 1) in the name of Vivacy, sodium hyaluronate (NaHA) fibers (1 g; molecular weight: about 2.7 MDa) and butanediol diglycidol Ether (BDDE) (54 mg) was used as starting material to prepare a composition comprising cross-linked hyaluronic acid. The composition thus obtained had a crosslinking NaHA concentration of about 30 mg / g and a degree of crosslinking X of about 0.12.

[0168] An aqueous solution of potassium sucrose octasulfate with a concentration of 3 mg / g was prepared according to Example 1.

[0169] Dilute the cross-linked NaHA hydrogel obtained in the previous steps in the aqueous solution of potassium sucrose octasulfate prepared above. The composition thus obtained is subsequently homogenized.

[0170] This resulted in a composit...

Embodiment 3

[0174] This example illustrates an exemplary composition comprising non-crosslinked hyaluronic acid, potassium sucrose octasulfate, and mannitol according to the invention.

[0175] According to the method of Example 1, using the aqueous solution of hyaluronic acid hydrogel at a concentration of 30 mg / g and potassium sucrose octasulfate at a concentration of 10 mg / g as raw materials, a gel containing non-crosslinked hyaluronic acid and potassium sucrose octasulfate was prepared. combination.

[0176] The addition of a 86 mg / g concentration of mannitol solution to the composition obtained above was carried out according to the method described in WO 2009 / 024670 in the name of Anteis.

[0177] The composition thus obtained comprises non-crosslinked NaHA at a concentration of 20 mg / g, mannitol at a concentration of 20 mg / g, and potassium sucrose octasulfate at a concentration of 1 mg / g; thus [HA] / [SOS by weight ] with a ratio of 20.

[0178] The composition obtained above was p...

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Abstract

A composition including at least one crosslinked or non-crosslinked hyaluronic acid, or one of its salts, and at least one water-soluble salt of sucrose octasulphate, to processes for the manufacture of said composition and to the use of said composition for the formulation of a viscosupplementation composition or for the formulation of a composition as a dermal filler or for the formulation of a cosmetic composition.

Description

Background technique [0001] Hyaluronic acid has been used in the cosmetic field for more than 15 years, where it has been proven to be harmless and effective. Currently, gels based on cross-linked hyaluronic acid derived from biofermentation are the most widely used products in the cosmetic filler gel market or as fillers. Indeed, in the cosmetic field, non-resorbable implants are used less and less and gels based on other polysaccharides have been abandoned because of side effects or because of the risk of viral contamination due to their animal origin. [0002] The use of hyaluronic acid derived from biological fermentation in areas such as filling wrinkles, viscosupplementation, ophthalmic treatment or urinary incontinence treatment is all more recognized and favored due to its natural occurrence In the human body, especially naturally present in the dermis, synovial fluid and cornea, the risk due to side effects is minimized. [0003] Nevertheless, due to the fact that h...

Claims

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Application Information

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IPC IPC(8): A61P19/02A61K8/60A61K8/73A61Q19/08A61K31/7016A61K31/728A61P27/04A61K47/36
CPCA61K31/728A61K31/167A61K2800/91A61K31/7016A61K47/36A61K8/735A61Q19/08A61K8/60A61K45/06A61P17/00A61P19/02A61P27/04A61P37/02A61K2300/00
Inventor 埃斯特尔·皮龙热雷米·邦贝唐
Owner LABES VIVACY
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