Preservative-free ophthalmic in-situ gelling agent and preparation method thereof
A technology of gelling agent and preservative, applied in the field of pharmaceutical preparations, can solve the problems of difficult insertion and removal, poor patient compliance, and reduced patient compliance, so as to achieve good bioadhesion and prolong the retention time in the eye , increase the effect of absorption and bioavailability
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Embodiment 1
[0040] Under the 100-level environment, 3.00g chitosan was dissolved with deionized water and 2.10g acetic acid to obtain a chitosan solution, and 0.30g carbomer 407 was added to the chitosan solution, and heated to dissolve to obtain a mixed solution; Add 0.50g sodium hyaluronate, 0.02g sorbitol, 3.80g glycerol and 0.01g vitamin E to the solution, mix well; add 0.50g sodium bicarbonate to adjust the pH value, add 0.80g glucose to adjust the osmotic pressure, add Deionized water to 1000mL, sterilized by a microporous membrane, then subpacked in small doses to obtain the ophthalmic in-situ gelling agent of the present invention.
Embodiment 2
[0042] Under the 100-level environment, 6.00g chitosan was dissolved with deionized water and 3.15g acetic acid to obtain a chitosan solution, and 0.90g carbomer 407 was added to the chitosan solution, and heated to dissolve to obtain a mixed solution; Add 0.80g sodium hyaluronate, 0.03g mannitol, 6.32g glycerin and 0.01g vitamin E to the solution, mix well; add 0.75g sodium bicarbonate to it to adjust the pH value, add 1.00g glucose to adjust the osmotic pressure, add Deionized water to 1000mL, sterilized by a microporous membrane, then subpacked in small doses to obtain the ophthalmic in-situ gelling agent of the present invention.
Embodiment 3
[0044] Under the 100-level environment, 10.00g chitosan was dissolved with deionized water and 2.68g acetic acid to obtain a chitosan solution, and 1.20g carbomer 940 was added to the chitosan solution, and heated to dissolve to obtain a mixed solution; Add 1.00g sodium hyaluronate, 0.03g sorbitol, 6.32g glycerol and 0.02g vitamin E to the solution, and mix well; add 0.50g sodium bicarbonate to adjust the pH value, add 0.90g glucose to adjust the osmotic pressure, add Deionized water to 1000mL, sterilized by a microporous membrane, then subpacked in small doses to obtain the ophthalmic in-situ gelling agent of the present invention.
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