1258results about How to "Reduce the number of medications" patented technology

The invention provides a zinc thiazole-containing bactericidal composition, which contains an active compound I and a bactericidally active compound II, wherein the active compound I is zinc thiazole; the bactericidally active compound II may be any one of a methoxyacrylate bactericide, a triazole bactericide, an amide bactericide, an iminazole bactericide, a dicarboxylic imide bactericide, a carbamic acid ester bactericide, an antibiotic bactericide, an oxazole bactericide, a morpholine bactericide, a pyrimidine bactericide, a quinazolone bactericide, a dithiocarbamate bactericide or other given bactericides.

The invention belongs to the field of plant protection, and in particular relates to an agricultural composition taking oligosaccharide and sulphur as synergistic components and an application of the agricultural composition in prevention and treatment of agricultural pests. The mass part ratio of oligosaccharide to sulphur is 1:(0.1-200) and the mass part ratio of oligosaccharide to sulphur to other pesticide components is 1:(0.1-200):(0.1-100). In the composition, oligosaccharide is pectin oligosaccharide, sodium alginate oligosaccharide or chitosan oligosaccharide. The synergistic composition containing oligosaccharide and sulphur can be processed to particles, suspending agents and the like with other insecticidal and mite-killing components or sterilizing components to realize the synergistic effect of the agricultural composition, and the agricultural composition is used for preventing and treating nematode, red spiders, Phyllocoptruta oleivora Ashmead or powdery mildew of crops.

The invention discloses an agricultural sterilizing composite containing thifluzamide, which is a sterilizing composite containing a first active ingredient thifluzamide, second active ingredients including difenoconazole, hexaconazole, propiconazole, cyproconazole and tebuconazole, and third active ingredients including tricyclazole, isoprothiolane, fenoxanil, Kanamycinum, prochloraz and azoxystrobin, wherein the weight ratio of the first active ingredient to the second active ingredient to the third active ingredient is (1-6) : (1-6) : 6. The sterilizing composite can be applied to controlling rice sheath blight disease, rice false smut and rice blast, and has reasonable ingredients, curing and protecting function, good sterilizing effect, less times of spraying insecticide and lower cost of spraying insecticide. In addition, the activity and the sterilizing effect of the sterilizing composite are not simple addition of the activity of active ingredients, but remarkable synergism isachieved. The invention has good safety on plants, slows down the generation of resistance and meets the safety requirement on agrochemicals.

The invention relates to a long acting sustained-release formulation containing dopamine-receptor stimulant medicine, which comprises 5-5- wt% of effective dose of dopaminergic acceptor medicaments, and 50-95 wt% of medicinal macromolecular auxiliary materials.

The invention relates to the field of Chinese medicine, and discloses a Chinese medicinal composition for preventing and treating xerophthalmia. The composition comprises chrysanthemums, medlar, phellodendron, red sage roots, pearls, borneol and menthol. The medicinal composition preferably comprises the following in part by weight: 2.5 to 3 parts of chrysanthemums, 2.5 to 3 parts of medlar, 2.5 to 3 parts of phellodendron, 1.5 to 2 parts of red sage roots, 0.08 to 0.1 parts of pearls, 0.08 to 0.1 parts of borneol and 0.15 to 0.2parts of menthol. The invention also provides a wet application of the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition has the effects of clearing heat, releasing toxin and moistening dryness, enables people to feel cool and comfortable after using the composition, and has the advantages of no toxic or side effects, easy absorption, quick response, good curative effect and good application prospects.

The invention relates to a disinsection composition containing a matrine and a neonicotinoid insecticide, and application thereof. The composition mainly uses the matrine and the neonicotinoid insecticide and is prepared by an auxiliary agent and an excipient to form microemulsion, emulsion in water, suspending agent, water dispersible granule, wetting powder and missible oil, wherein the mass percentage of the matrine and the neonicotinoid insecticide is 30:1-1:100. The disinsection composition has higher synergy effect, prevents pests from becoming resistant to drugs, prolongs the service life of pesticides and reduces pesticide residue. The composition can be used for preventing and treating homoptera, lepidoptera, thysanoptera, coleopteran and diptera on crops, particular for rice planthopper, trialeurodes vaporariorum, aphid, tryporyza incertulas, chilo suppressalis, thrips, paddy weevil and gall midge.

The invention discloses a medicinal composition for treating or preventing the obesity and metabolic syndromes, and belongs to the medicine field. The medicinal composition treats orlistat and acarbose as medicinal active components, so the application amount of orlistat in the medicinal composition is substantially reduced, thereby the risk of the damage of orlistat to the liver of a body is reduced. The medicinal composition has a substantial synergistic effect when the medicinal composition is used for treating or preventing the obesity and the metabolic syndromes, can reduces the diabetes and angiocardiopathy suffering risks of obese patients, and has a wide medical application prospect.

The invention discloses an andrographolide suspension capable of obviously improving oral bioavailability and realizing slow release by intramuscular injection or hypodermic injection, a method for preparing the suspension and a medical application of the suspension. The preparation consists of a general suspension and a dry suspension and can be taken orally or subjected to hypodermic injection or intramuscular injection. The method is characterized in that the raw materials are processed to obtain micron-sized or nanometer-sized particles, a certain amount of auxiliary materials are added, thus the bioavailability is improved and the stability of the preparation is ensured. The whole preparation process is simple and controllable, and the industrial production can be realized. Compared with a preparation prepared from common raw materials, the preparation prepared by the preparation method, disclosed by the invention, has the advantages that the bioavailability can be obviously improved by taking orally; and the low release effect can be realized after intramuscular injection or hypodermic injection.

The invention provides an application of hyaluronic acid and hyaluronate in preparation of a composition for treating and alleviating xerostomia and the composition for treating and alleviating xerostomia. As hyaluronic acid and hyaluronate thereof are in double helix columnar structures, and massive hydroxyls exist inside the double helix structures, the hyaluronic acid and hyaluronate thereof have a very good water holding effect, so that the hyaluronic acid and hyaluronate thereof have lasting moisturizing effect on oral cavity. Furthermore, the hyaluronic acid and hyaluronate thereof can promote wound healing and have the effects of healing anabrosis and the like. In addition, the hyaluronic acid and hyaluronate thereof are colorless and tasteless and free from toxicity, belong to synthetic substances in human body, and are easy to be compatible with ions such as sodium, potassium, calcium, zinc, ferrum and silver ions, so that the hyaluronic acid and hyaluronate thereof have the taste which is suitable for being accepted by human body.

The invention relates to a pesticide compound which consists of Clothianidin and Carbaryl and can be processed into a wettable powder, a water dispersible granule, a suspending agent, an aqueous emulsion, a microemulsion and missible oil and is used for controlling the piercing-sucking pests on fruit trees, economic crops and vegetables, in particular to controlling the resistance plant lice and white flies on the vegetables.

The invention belongs to the technical field of pesticide, specifically relates to an insecticidal composition with pymetrozine comprising effective ingredients of pymetrozine and abamectin with weight% of 1-80 : 0.1-20. The inventive composition is added with normal adjuvants and excipients, except for the effective ingredients of pymetrozine and abamectin, to prepare as suspending agent, wettable powder, water dispersible granule for the control of bemisia tabaci, aphid, whitefly, leafhopper, rice fulgorid in the cotton, rice, vegetables and fruit trees, with obvious synergy, and increased insecticidal spectrum of pesticide. The effect of the present invention is obviously higher than that of the single agent thereof.

The invention discloses compound florfenicol injection for an animal. Every 1,000ml of the compound florfenicol injection contains 50 to 300g of florfenicol, 50 to 300g of doxycycline hydrochloride, 150 to 800g of organic solvent, 5 to 90g of complexing agent and 0.2 to 1g of antioxidant. The compound florfenicol injection has the advantages that: (1) the preparation is high in complexation degree and stable in quality, and the doxycycline hydrochloride injection is instable in property; (2) the injection is low in dosage and convenient to use, and the injection twice can be finished at one time; (3) the injection greatly saves the labor cost for veterinary medicine under an intensive feeding condition; and (4) the production of the preparation is controllable in terms of technical conditions, the injection is suitable for industrial production, various raw and auxiliary materials are needed to be accurately weighed in the production process, only the reaction temperature and the reaction time are needed to be controlled without any special technical requirement, and the production technology is easy to master and control.

The invention discloses a blank polycystin liposome and a topotecan hydrochloride containing polycystin liposome and a preparation method thereof; the blank polycystin liposome comprises the following ingredients by mass parts: 1 part of lipid ingredient and 0.1-50 parts of ion gradient regulator, wherein the lipid ingredient comprises amphipathy lipid and neutral lipid which have 5-36:1 molar ratio. The topotecan hydrochloride containing polycystin liposome comprises drug active ingredient-topotecan hydrochloride and the blank liposome which is used as a carrier; in the invention, the blank polycystin liposome which is encapsulated with the encapsulate is prepared firstly, and then the topotecan hydrochloride is led to penetrate through a phospholipid membrane to be loaded in liposome internal water phase by adopting a transmembrane gradient active medicine carrying method, so as to obtain the topotecan hydrochloride containing polycystin liposome. In the invention, the utilization rate of the raw materials is high, the medicine carrying concentration is high, and the polycystin liposome has good slow release function in in-vivo and in-vitro experiments and has better anti-tumor effect.

The invention discloses herbicide for expanding a glyphosate weed control spectrum. The herbicide comprises the following active ingredients in parts by weight: 20-80 parts of glyphosate, 0.5-5 parts of f fluoroglycofen-ethyl and 0.5-6 parts of quizalofop-p-ethyl; besides the active ingredients, a surfactant, a carrier or/and auxiliary material and the like also can be added to prepare water aqua, emulsion in water, wettable powder, soluble powder, water dispersible granules, suspension concentrate or oil suspension. The herbicide has obvious synergized action by compounding of the three herbicides, is wide in herbicide control spectrum, long in effective duration, and small in environmental pollution, and the drug dosage and the drug times are reduced.

The invention discloses a sustained-release granule for controlling storage diseases and insect pests. The sustained-release granule comprises a granular inert carrier. Effective components are adsorbed on the granular inert carrier and comprise allyl isothiocyanate, glutaraldehyde and a stabilizing agent. A film-coating agent coats the surface of the granular inert carrier; the weight percentageof the granular inert carrier is 55-96.9 percent; the weight percentage of the allyl isothiocyanate is 1-20 percent; the weight percentage of the glutaraldehyde is 1-10 percent; the weight percentageof the stabilizing agent is 0.1-5 percent; and the weight percentage of the film-coating agent is 1-10 percent. The invention aims to provide the sustained-release granule for controlling the storagediseases and insect pests and a preparation method thereof, wherein the sustained-release granule has favorable controlling effect for main storage insect pests and germs, can control the diseases and insect pests with long action, reduce the drug-applied times and the drug-applied cost, is safe and economic in various links of production, transportation, storage, application and the like, saves labor power and physical resources, cannot damage the environment and is green and safe.

The invention relates to the field of pharmaceutical preparations and particularly relates to a slow-release micropill preparation containing enrofloxacin and a preparation method of the preparation. The slow-release micropill provided by the invention is formed by coating an enrofloxacin micropill; the enrofloxacin micropill comprises enrofloxacin and auxiliary material and is formed through extruding and rounding; the auxiliary material is any one or more of microcrystalline cellulose, starch, cane sugar, artificial gum, lactose and sodium carboxymethyl starch; according to weight percent, the auxiliary material in the micropill accounts for 70% to 95%; and coating is made of high-molecular enteric material, film forming material, opaquer and the like. The slow-release micropill preparation has the characteristics of slow release and high bioavailability, can be used for treating bacteria and mycoplasma infection of livestocks, and has better curative effect on chronic respiratory diseases, colibacillosis and salmonellosis, and the frequency of medicine taking can be reduced; and in addition, the slow-release micropill provided by the invention has the advantages that the stability of medicine is improved, and peculiar bitter of enrofloxacin can be covered completely, so that feeding intake of the animals is not influenced, and the recovery rate is improved.

The invention relates to ivermectin sustained-release microspheres used as an animal medicine for animal injection, and a preparation method thereof. The invention belongs to an interdisciplinary field of biomedical polymer materials and controlled release preparations. The invention discloses ivermectin sustained-release microspheres, which are characterized in that: the ivermectin sustained-release microspheres have particle sizes of 0.1 to 10mum, a medicine loading capacity of 20% to 35%, and an entrapment rate of above 80%. The preparation method of the ivermectin sustained-release microspheres comprises steps that: a carrier material and the medicine ivermectin with a mass ratio of 1:1-10 are dissolved in an organic solvent; the solution is processed through supersonic wave or mechanical stirring, such that the solution is emulsified into an oil phase, wherein a volume ratio of oil phase to water phase is 1:5-10; under a temperature of -10 DEG C to 30 DEG C, the oil phase is injected into a water phase disperse medium solution step-by-step; constant-temperature magnetic stirring is carried out with a rotation speed of 400 to 10000rpm, the mixture is sufficiently emulsified, such that an S/O/W type emulsion is obtained; the emulsion is stirred under room temperature for 3 to 4 hours, such that the organic solvent is sufficiently volatilized; the obtained product is centrifuged, washed, collected, and is vacuum-dried with a pressure of 0.01 to 0.04MPa under room temperature for 10 to 12 hours or is lyophilized under a temperature of -0 DEG C to -20 DEG C. With the processes, ivermectin sustained-release microspheres with particle sizes of 0.1 to 10mum are obtained.

The invention discloses a dust agent with biological pesticides as effective components and a using method thereof. The biological pesticide dust agent adopts raw drugs, mother powders, powder agents, wettable powders, fine granules and other powder preparations of one or more biological pesticides as the effective components, a certain amount of a carrier and auxiliary agents are added, and the biological pesticide dust agent is prepared through air flow pulverizing; the fineness of the biological pesticide dust agent comprises that D90 is less than 53 [mu]m, D50 is less than 37 [mu]m, and D10 is more than 2 [mu]m. The dust agent is applied by a powder spraying method, and can be used for prevention and treatment of diseases and insect pests in facilities or outdoor horticultural plants. After application, the dust agent can perform all-dimensional motion in air and can be lastingly suspended in the air, so that the dust agent can be well diffused, penetrated and go deep to a relatively hidden part in a plant canopy, has high attachment uniformity, and is in favor of playing a better drug effect. In the production application, the using method has the characteristics of water saving, labor saving, effort saving and drug saving, is not affected by climate conditions, and overcomes the disadvantages that a conventional atomizing method adopts much water for drug application and easily induces high wet disease.

The invention discloses a gliclazide tablet. The gliclazide tablet is directly tabletted by gliclazide solid dispersoid particles and auxiliary materials accepted pharmaceutically; and the gliclazide solid dispersoid particles are prepared according to the following method: citrate and polyvinyl acetate are heated and molten in a hot melt extruder, then gliclazide is added inside to melt, and the molten liquid is extruded and granulated. The preparation method of the invention is simple in preparation production technology; a patient just takes the medicine once every day, the active components slowly release in the body of the patient, and the plasma concentration is steady; and the gliclazide has long effectiveness, so that the times of administration are reduced, the toxic and side effects are lowered, and the treatment cost is greatly reduced.