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Resveratrol nano emulsion anti-cancer medicine

A technology of resveratrol and anticancer drug, applied in the field of medicine, can solve the problems of short half-life, easy decomposition, low bioavailability, etc., and achieve the effects of reducing enzymatic hydrolysis, improving solubility and simple preparation method

Inactive Publication Date: 2008-07-09
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an anti-tumor drug, resveratrol has not been marketed yet, because resveratrol itself has a series of problems, such as: low bioavailability, short half-life, only 4 hours in the body; easy to decompose when exposed to light and heat Wait

Method used

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  • Resveratrol nano emulsion anti-cancer medicine
  • Resveratrol nano emulsion anti-cancer medicine
  • Resveratrol nano emulsion anti-cancer medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Accurately weigh 4.5g of polyoxyethylene ether (40) hydrogenated castor oil, 1.0g of ethanol (dissolving 0.1g of resveratrol in it), 0.5g of IPM, stir and mix well at 20°C, and then slowly add distilled water to it , Stirring while adding, the viscosity of the system is small at the beginning, as the amount of water increases, the system becomes viscous, continue to add distilled water and stir continuously, when the system suddenly becomes thinner, O / W type colorless is produced at this time Transparent resveratrol nanoemulsion, claims its weight 15.0g.

Embodiment 2

[0028] Accurately weigh 4.5g of castor oil polyoxyethylene ether, 1.0g of ethanol (dissolving resveratrol 0.015g in it), 0.5g of isooctyl ester, stir and mix well at 22°C, then slowly add distilled water therein, while Stir while adding. At the beginning, the viscosity of the system is small. As the amount of water increases, the system becomes viscous. Continue to add distilled water and stir continuously. When the system suddenly becomes thinner, the O / W type colorless and transparent white is produced. Veratrol nanoemulsion claims its weight as 15.0g.

Embodiment 3

[0030] Accurately weigh 3.5g of polyoxyethylene ether (40) hydrogenated castor oil, 1.0g of ethanol (0.1g of resveratrol dissolved in it), 1.5g of ethyl acetate (0.05g of resveratrol dissolved in it), and the Then, slowly add distilled water to it, and stir while adding. At the beginning, the viscosity of the system is small. As the amount of water increases, the system becomes viscous. Continue to add distilled water and keep stirring. When the system suddenly becomes thinner, Produced at this moment is O / W type colorless and transparent resveratrol nanoemulsion, claiming that its weight is 15.0g.

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Abstract

The present invention discloses a resveratrol nano-emulsion anticancer drug which is characterized in that the particle size of the nano-emulsion anticancer drug is between 1nm and 100nm; the raw materials and the weight percentage thereof are: 0.1 percent to 2.0 percent of the resveratrol, 33.3 percent and 42.9 percent of surfactant or cosurfactant, 3.3 percent to 10.0 percent of oil and the distilled water with the rest quantity, and the sum of the percentage of the raw materials is 100 percent. The nano-emulsion has small particles, uniform distribution, little viscidity and good fluidity. After the resveratrol is made into the nano-emulsion, which can increase the anticancer effect thereof obviously, prolong the half-life and reduce medication times; the nano-emulsion can prevent the resveratrol from being oxygenated and increase the stability of the resveratrol, and the preparation method is simple with low energy consumption.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of an anticancer drug resveratrol, in particular to a resveratrol nanoemulsion anticancer drug. Background technique [0002] Resveratrol (RES) is a phytoalexin widely found in fruits, traditional Chinese medicine and wine, and has various biological effects. It is a polyphenolic compound with the chemical name 3,4′,5-trihydroxy-stilbene (3,4′,5-trihydroxystlbene), white or off-white powder, easily soluble in acetone, ethyl acetate, di Methyl sulfoxide, ethanol, insoluble in water. After entering the blood circulation, RES is first metabolized in the liver, combined with glycosides, and has a half-life of 4 hours in the body. It is suitable for cancer chemoprevention and chemotherapy of liver cancer, breast cancer, lung cancer, gastric cancer, colon cancer, leukemia and prostate cancer. In recent years, the research on the anti-cancer mechanism of RES has become more and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/05A61P35/00
Inventor 欧阳五庆杨宝平
Owner NORTHWEST A & F UNIV
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