The invention relates to the technical field of radioactive
isotope preparation, and discloses a high-purity
terbium-149 separation preparation method and
system based on an electromagnetic
mass spectrometry tandem
separation technology, and the method comprises the following steps: bombarding a 151Eu target material based on an alpha beam to obtain an irradiated target material of the 151Eu target material, and carrying out high-temperature gasification on the irradiated target material to obtain the high-purity
terbium-149. The method comprises the following steps: irradiating a target material to obtain
nuclide steam of the irradiated target material, carrying out strong electromagnetic separation on isobaric elements of the
nuclide steam to obtain a crude separation target product of the
nuclide steam, and carrying out fine separation on the crude separation target product based on a pre-calibrated high-resolution
mass spectrometer to obtain
terbium-149 ions of the irradiated target material. Condensing and collecting the terbium-149 ions, and dissolving the terbium-149 ions into a medical-grade
terbium chloride solution of the terbium-149 ions; according to the method, high-efficiency, high-purity, low-energy-consumption and short-process preparation of terbium 149 is realized, and the large-scale production requirements of targeted alpha therapy on high-purity and short-half-life alpha nuclide can be met.