34results about How to "Inhibit synthesis" patented technology

The invention discloses a triazine desulfurizer and a preparation method thereof, and belongs to the technical field of gas purification. The triazine desulfurizer is mainly prepared from the following raw materials in percentage by weight: 20 to 50 weight percent of triazine derivative, 10 to 15 weight percent of sterically hindered amine, 3 to 7 weight percent of stabilizer, 1 to 3 weight percent of synergist, 0.5 to 1.5 weight percent of penetrant, 0.5 to 1.5 weight percent of inhibitor, 1 to 2 weight percent of additive and the balance of water, the preparation method of the triazine derivative comprises the following steps: adding 2-(diphenylphosphino) ethylamine into a toluene solvent, adding a paraformaldehyde aqueous solution in batches under a stirring condition, and reacting for 2-8 hours to obtain the triazine derivative. According to the triazine desulfurizer and the preparation method thereof provided by the invention, the triazine derivative and the sterically hindered amine are taken as a host, and the stabilizer, the synergist, the penetrant, the inhibitor and the assistant are compounded, so that the scaling trend of the triazine desulfurizer in an oil and gas well can be slowed down, the dissolution rate of hydrogen sulfide and the mass transfer rate in a solution are increased, and the desulfurization reaction is promoted; the desulfurization effect and the desulfurization rate are improved, and meanwhile, a very good scale inhibition effect is also achieved.

The application discloses application of ginsenoside Rb1 in preparation of biological products for improving liver aging and abnormal lipid metabolism. The application research finds that ginsenoside Rb1 (20 mg / kg) can significantly improve the aging phenotype and lipid metabolism disorder of the aging liver through multi-target synergistic effect, and the mechanism is related to inhibition of lipid synthesis, improvement of lipid transport and promotion of lipid oxidation. The application provides a new drug candidate and action mechanism for intervention of aging-related liver diseases such as MASLD / MASH, and has an important clinical application prospect.

The invention relates to the technical field of bactericides for crops, in particular to a bacillus cereus-containing bactericidal composition and application thereof in prevention and control of camellia oleifera anthracnose. The active ingredients of the bactericidal composition comprise bacillus cereus WR-12 and diflumetofen sulfanilamide. According to the bactericidal composition, the synergistic bactericidal effect is enhanced by compounding a biological fungicide and a chemical fungicide, the development of drug resistance of pathogenic bacteria is delayed, the negative influence of chemical pesticides on the environment is reduced, green and efficient prevention and control of camellia oleifera anthracnose are achieved, and sustainable development of the camellia oleifera industry is promoted.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

This invention discloses a topical Chinese medicine preparation for treating erosive tinea pedis and its preparation method, belonging to the technical field of topical Chinese medicine preparations. The preparation consists of 15-25 parts clove, 10-20 parts alum, 20-30 parts Polygonum cuspidatum, and 10-18 parts Psoralea corylifolia, and is prepared into a spray using a 45% low-alcohol countercurrent extraction process. This invention achieves synergistic effects through a three-stage targeting mechanism: eugenol inhibits fungal CYP51A1 enzyme, blocking ergosterol synthesis (targeted enrichment rate 62.1%), resveratrol inhibits the NF-κB pathway, reducing inflammatory response, and psoralen activates the PI3K / AKT pathway, promoting epidermal repair (repair rate 69.2%). The alcohol concentration of the preparation is reduced to 45%, eliminating irritation to broken wounds. A single application takes only 1 minute, and a 7-day treatment course has a clinical efficacy rate of 84.7%, saving 320 yuan per person compared to traditional methods. This invention overcomes the shortcomings of existing drugs for treating erosive tinea pedis, such as strong irritation, cumbersome operation, and limited efficacy, and fills the gap in the category of specialized preparations, with significant social benefits and market prospects.

The present application belongs to the technical field of quorum quenching enzyme preparation, and particularly relates to a multi-target quorum quenching enzyme preparation and a preparation method and application thereof, such as being mainly used for inhibiting the virulence factors of Pseudomonas aeruginosa, and including acyl homoserine lactone acyltransferase AiiO protein and 3-hydroxy-4-oxoquinolone 2,4-dioxygenase AqdC protein, and the mass ratio of the two is 20:(1-25); such as being mainly used for inhibiting the virulence factors and the synthesis of biological membranes of Pseudomonas aeruginosa, and further including deferiprone, and the mass ratio of AiiO, AqdC and deferiprone is 20:(1-25):(0.695-2.78), the present application can target the Las, Rhl and PQS of Pseudomonas aeruginosa, the yield and stability of the prepared AqdC protein are both high, the two types of enzymes are used in combination after the regulation amount, and the virulence factors regulated by different quorum sensing pathways in Pseudomonas aeruginosa are effectively inhibited; the regulation amount of deferiprone is used in combination with the two types of quorum quenching enzymes, and the virulence and biological membranes of Pseudomonas aeruginosa can be effectively inhibited in a comprehensive manner.

This invention discloses a Chlorella heptapeptide TGPLGSR with multi-target lipid-lowering activity, its preparation method, and its applications. The amino acid sequence of this heptapeptide is Thr-Gly-Pro-Leu-Gly-Ser-Arg. The preparation method includes: performing ultraviolet and electroporation combined mutagenesis on wild-type Chlorella proteoglycans to obtain a high-protein-content mutant algal strain; obtaining algal protein through fermentation and synergistic extraction and purification with alcohols; directionally digesting the protein with alkaline protease, followed by enriching the active peptide components through ultrafiltration and gel chromatography; and finally, screening the heptapeptide using liquid chromatography-mass spectrometry (LC-MS), computer-aided prediction, and molecular docking techniques. This heptapeptide exhibits potent inhibitory activity against pancreatic lipase and can dose-dependently reduce the accumulation of triglycerides and cholesterol in 3T3-L1 cells. Its mechanism involves multiple target pathways, including inhibition of MMP-9, activation of AMPK phosphorylation, and downregulation of PNLIP, and it can be used to develop lipid-lowering functional foods or health products.

The invention discloses an organic photo-thermal eutectic material based on crown ether derivatives and a preparation method and application thereof, and relates to the technical field of organic photo-thermal materials. Wherein the organic eutectic material is a host-guest eutectic formed by assembling an electron-rich donor molecule crown ether derivative and an electron-deficient acceptor molecule through a charge transfer effect. Compared with a single subject or object, the eutectic material has a remarkable near-infrared light absorption characteristic and can be applied to interface water evaporation. Tedious and complex molecular design and synthesis processes are avoided, the preparation process is simple and easy to implement, and meanwhile, the polyurethane foam loaded with the organic photo-thermal eutectic material shows an excellent water evaporation advantage and shows a great potential application value in the fields of seawater desalination and the like.

The invention provides research on a mechanism for regulating red bayberry fruit anthocyanin synthesis through optical signals and application of the mechanism. By treating Dongkui waxberries with different light-transmitting bags, the quality characteristics of mature fruits are analyzed, and comprehensive analysis is performed in combination with transcriptome and metabolome. The result shows that the bagging in the young fruit period significantly reduces the fruit quality, the black light-proof bag inhibits the fruit color change and anthocyanin synthesis, and the bagging influence in the color change period is small. Metabolome and transcriptome analysis shows that differential metabolites are enriched in anthocyanin synthesis and flavonoid metabolic pathways, related differential metabolites are identified, and core regulation transcription factors HY5 and DF1 participate in the photoregulation anthocyanin accumulation process. According to the invention, an optical signal regulation and control mechanism is defined, related factors and metabolites are identified, and a basis is provided for quality improvement and cultivation technology optimization of waxberries.

This invention discloses a full leaching process for waste lithium iron phosphate (LFP) black powder, belonging to the field of LFP black powder recycling. The process includes the following steps: S1, raw material pretreatment: obtaining pretreated black powder with a moisture content ≤1%; S2, preparation of an organic acid leaching agent; S3, first iron-phosphorus leaching; S4, filtering the reaction system of step S3 using a 0.22μm plate and frame filter to obtain an iron-phosphorus leaching solution and lithium-containing solid filter residue; S5, subsequent lithium leaching; S6, filtering the reaction system of step S5 using a 0.22μm plate and frame filter to obtain a lithium leaching solution and solid residue; S7, adjusting the pH of the iron-phosphorus leaching solution to 3.5–4.0 with ammonia water, removing impurities, and crystallizing to obtain battery-grade iron phosphate; concentrating the lithium leaching solution under reduced pressure at 45–50℃, adding diammonium hydrogen phosphate to precipitate lithium, and crystallizing to obtain battery-grade lithium phosphate. This invention involves no strong acids or toxic reagents throughout the entire process, resulting in minimal equipment corrosion.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition consists of bulbus fritillariae cirrhosae, kelp, thunberg fritillary bulb, turmeric, endothelium corneum gigeriae galli, raw hawthorn and selfheal. According to the application, the bulbus fritillariae cirrhosae and the bulbus fritillariae thunbergii are compatible to synergistically exert the effects of reducing phlegm and resolving The endothelium corneum gigeriae galli and the raw hawthorn have the effect of removing food retention, the selfheal has the effect of clearing liver and removing stasis, and all the medicines are combined to achieve the effects of reducing phlegm, removing blood stasis, softening hard mass and eliminating diseases. Experiments show that the traditional Chinese medicine composition can significantly improve the liver function of Wilson disease model mice, reduce collagen deposition of liver tissues, down-regulate fibrosis markers and inhibit activation of hepatic stellate cells.

The application discloses a method for regulating activity of a pear self-incompatibility gene PpS-RNase promoter and belongs to the field of plant genetic engineering. The application determines a 1284bp promoter sequence of the pear PpS-RNase gene, and verifies that the activity of the pear PpS-RNase gene promoter is induced by brassinosteroid in a stable transformation system of Arabidopsis thaliana, and the synthesis of endogenous brassinosteroid can be inhibited to significantly reduce the expression of the pear PpS-RNase gene, thereby providing a new idea for solving pear self-incompatibility mediated by the pear PpS-RNase gene and interspecific hybrid breeding.

The application discloses a flexible arrangement and space-occupying-free high-voltage electrostatic field kiwi fruit storage multipurpose system and method, which takes a standard refrigerator as a main body, is internally insulated and coated, and is composed of a high-voltage direct-current power supply, a cable electrode array, a grounding belt and an intelligent control module. A 30kV direct-current high voltage is adopted to form a stable non-uniform electric field, and the electrode can be precisely adjusted in distance and prevented from shaking, and is suitable for large-scale storage. Taking "Xu Xiang" kiwi fruit as an object, under the condition of 0-2 DEG C and 90%-95% humidity, continuous electrostatic treatment can inhibit respiration, delay softening, reduce water loss, target inhibit cellulase, polyphenol oxidase and other activities, and improve antioxidant capacity; directly inhibit alternaria alternata, reduce the incidence of soft rot; inhibit PAL activity, reduce lignin accumulation, alleviate low-temperature cold damage, and at the same time, maintain soluble solids, vitamin C and other nutritional ingredients. The application is safe, residue-free, suitable for a standard refrigerator, and provides an efficient physical preservation scheme for kiwi fruit industrialization storage.

The application provides an ALDH1L1 protein and application thereof, and belongs to the technical field of genetic engineering. The amino acid sequence of the protein is shown as SEQ ID NO:1, and the nucleotide sequence of the coding gene is shown as SEQ ID NO:2. The application also provides application of a reagent for inhibiting ALDH1L1 gene expression or protein activity in preparation of a product for inhibiting growth and development of insects, and a high-throughput screening method based on the protein. Experiments prove that teflubenzuron can specifically bind to ALDH1L1 and inhibit the enzyme activity thereof; the ALDH1L1 gene of Drosophila is knocked out by using a CRISPR / Cas9 system, so that the egg laying amount is reduced, the development period is prolonged, and the pupation rate and eclosion rate are significantly reduced. The application firstly determines that ALDH1L1 is a direct action target of benzoylurea insecticides, and can be used for screening of new insecticides, monitoring of pest resistance and creation of green pesticides.

The present application relates to the technical field of genetic engineering, and particularly relates to application of miR-27b-3p in preparation of products for regulating cell proliferation and testosterone synthesis. The present application constructs Inhibitor and Mimics sequences with miR-27b-3p gene as a target, and for the first time proposes that overexpression of miR-27b-3p gene can significantly inhibit proliferation and testosterone synthesis of goat testicular interstitial cells, and inhibition of miR-27b-3p gene can significantly promote proliferation and testosterone synthesis of goat testicular interstitial cells. The present application has important significance for improving development of goat testis, and provides technical support for research and development of products for regulating proliferation and testosterone synthesis of goat testicular interstitial cells with miR-27b-3p gene as a target.

The application belongs to the technical field of skin care products, and specifically discloses a soothing and repairing composition containing a bionic sebum component and a preparation method thereof. The composition is composed of an oil phase and an aqueous phase. The oil phase comprises a bionic sebum, a farnesol-mesyl glyceride conjugate, and an enzymatic oat anthranilamide-phytosphingosine ion pair. The aqueous phase comprises deionized water, a humectant, and a crocin-hydrogenated lecithin dispersion. The application induces the liquid crystal reconstruction of the bionic sebum by sacrificing a template, so that a plurality of modified active substances form a gradient distribution from a hydrophobic core to a hydration layer in a lamellar structure, and are coupled with the skin carboxylic acid esterase activity to realize cascade release, thereby solving the problems of compatibility conflict, spatial positioning disorder and passive release of multiple active substances.

The invention discloses an application of cothine dimethyl ether and sakuranetin as a bacteriostatic agent of a plant pathogen fusarium graminearum, and an application of the cothine dimethyl ether and the sakuranetin in prevention and treatment of wheat scab. According to the present invention, the prevention and the control on the wheat scab are achieved by inhibiting the mycelial growth of fusarium graminearum, inhibiting the biosynthesis of deoxynivalenol, and / or inhibiting the expression of the deoxynivalenol synthesis key gene. Both the cocaine dimethyl ether and the sakuranetin are plant source natural products and have the characteristics of low toxicity, easiness in degradation, high environmental compatibility and the like. Experimental data provided by the invention fully prove that the compound is effective in inhibiting growth of fusarium graminearum and accumulation of DON, is safe and harmless to wheat, can be used as a green replacement or supplement means of a chemical bactericide, provides a new solution for green prevention and control of wheat scab, and has important application value and popularization prospect.

This invention relates to peptides with activities that inhibit sarcopenia, promote muscle growth, and inhibit fatty liver. The peptides according to the invention can promote the proliferation of muscle cells and their differentiation into muscle fibers, exhibiting muscle regeneration effects even in cases of muscle atrophy, and can significantly inhibit the expression of genes / proteins related to fat synthesis in hepatocytes. Therefore, the peptides according to the invention are expected to be effectively used to inhibit sarcopenia, promote muscle growth, and inhibit fatty liver.

The invention relates to an artemisia apiacea-containing penetration enhancing composition with skin cell repairing and relieving effects, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The research finds that the anti-inflammatory effect generated by only inhibiting an upstream anti-inflammatory path of an NF-kappa B channel is limited, and the anti-inflammatory effect can be remarkably enhanced by blocking a downstream conduction chain while inhibiting the NF-kappa B channel. On the basis, through the artemisia apiacea extract and the flos magnoliae extract, an upstream anti-inflammatory path is inhibited, recruitment and infiltration of inflammatory cells are reduced, a downstream conduction chain is blocked, and the anti-inflammatory effect is synergistically improved. Besides, through cooperation of the oat kernel oil, the jasmine flower oil and the squalane, on one hand, the solubility of fat-soluble active matter is improved, on the other hand, the composition can participate in repairing, stabilizing and optimizing the lipid structure of the skin cuticle, synchronously open the skin fat-soluble channel and convey the active matter more efficiently, and therefore the excellent relieving, repairing and stabilizing effects are achieved.

The application provides an application of a CNOT9 expression inhibitor in preparation of a medicine for preventing, alleviating and / or treating liver cancer. It is found for the first time that the mRNA and protein expression levels of CNOT9 in hepatocellular carcinoma (HCC) tissues are significantly higher than those in paracancerous and normal liver tissues, and the high expression is closely related to the prognosis indexes such as the overall survival and progression-free survival of patients, thereby establishing the value of CNOT9 as a liver cancer diagnosis marker and a new treatment target. Based on this, the application provides an application of a CNOT9 inhibitor in preparation of a medicine for preventing, alleviating and / or treating liver cancer. By down-regulating the expression of CNOT9 through siRNA, the proliferation activity, clonogenicity, migration and invasion ability of liver cancer cells HLF can be effectively inhibited. The application further provides a medicine composition comprising the inhibitor, thereby providing a brand-new target and effective intervention strategy for liver cancer treatment, and having a great clinical development prospect and application value.

The invention discloses an anti-gout traditional Chinese medicine composition, which is prepared from the following raw material medicines in parts by weight: 10 to 20 parts of sunflower disc, 3 to 6 parts of radix puerariae, 1 to 4 parts of plantain herb, 5 to 14 parts of corn stigma, 2 to 8 parts of semen coicis, 2 to 8 parts of poria cocos, 2 to 8 parts of dandelion and 1 to 4 parts of pawpaw, preferably 15 parts of sunflower disc, 5 parts of radix puerariae, 2 parts of plantain herb, 8 parts of corn stigma, 4 parts of semen coicis, 5 parts of poria cocos, 5 parts of dandelion and 3 parts of pawpaw, and discloses a preparation method of the anti-gout traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of resisting inflammation, diminishing swelling, relieving pain, reducing blood uric acid and dissolving sodium urate, and has a good effect on patients with hyperuricemia, red, swollen and hot pain of joints and uric acid crystal deposition.

This invention provides an oil-controlling composition, its preparation method, and its application. The composition comprises extracts from *Eryngium sibiricum*, sunflower seed, *Edelweiss*, and *Saussurea involucrata*. Cosmetic products containing this composition exhibit excellent oil-controlling, moisturizing, and soothing / repairing effects.

The application belongs to the technical field of plant breeding, and particularly relates to a seed pretreatment method and seedling raising method for improving the breeding efficiency of Carpinus putolekii, which comprises the following steps: disinfecting Carpinus putolekii seeds, and performing temperature-variable stratification treatment on the disinfected seeds to obtain pretreated Carpinus putolekii seeds; the temperature-variable stratification treatment comprises: 23-27 DEG C warm treatment for 30 days, and 3-5 DEG C cold treatment for 60 days. The pretreatment method can significantly shorten the germination time of Carpinus putolekii, improve the germination efficiency, and provide technical support for the protection and large-scale seedling raising of the species. The results of the examples show that, by using the method provided in the application, the germination time of Carpinus putolekii seeds is reduced to 14 days, the germination rate is 93.1%, and the seedling rate is 89.7%, so the germination is rapid, and the uniformity is high.

The invention discloses a preparation method of fluorinated alkene ether, which comprises the following steps: replacing alkene CFCl = CFCl in a 1, 2-difluorodichloroethylene method with hydrogen-containing fluorinated alkene CFH = CFX, carrying out fluorination reaction on the fluorinated alkene CFH = CFX, fluorine gas and fluorinated acyl fluoride (RCOF) under the action of a catalyst, and directly generating an intermediate (namely a fluorinated ether isomer mixture comprising RCF2OCFHCF2X and an isomer thereof RCF2OCFXCF2H) in one step, the intermediate continues to be subjected to a dehydrohalogenation reaction with alkali, and the product fluorinated alkene ether (RCF2OCF = CF2) is obtained. According to the method, synthesis, use and storage of an unstable intermediate, namely, hypofluoro acid ester RCF2OF with strong oxidation and high explosion risk can be effectively avoided, meanwhile, decomposition caused in the reaction process of special unstable raw material acyl fluoride such as ROCOF and fluorine gas can be reduced, and the safety is effectively improved; the problems of heavy metal use and pollution caused by a zinc powder dehalogenation process in a 1, 2-difluorodichloroethylene method are solved; the method has the advantages of short process flow, mild reaction conditions, environmental protection, high product purity and the like.

The utility model relates to the technical field of fresh flower preservation, in particular to a fresh-cut Chinese rose preservation box which comprises a box body and a box cover, a plurality of air holes are evenly formed in the box cover, and a silicon window film covers the air holes and is used for adjusting the concentration of oxygen and carbon dioxide in the box. A detection assembly, an atomizer, an ice bag bin and a fan are arranged in the box body, and the detection assembly comprises a temperature and humidity sensor, an ethylene sensor and a carbon dioxide sensor; the ice bag bin is located in the middle of the box body, an opening of the ice bag bin faces upwards, and ice bags are arranged in the ice bag bin. The atomizer is located in the middle of the box body, and a preservative is stored in the atomizer; blue light lamp strips are arranged on the inner sides of the box cover and the box body respectively. According to the fresh-keeping system, a multifunctional synergistic fresh-keeping system is formed by integrating an air-conditioning assembly, a low-temperature assembly, a monitoring assembly, an illumination assembly and the like, the problems of insufficient environment control, lack of physical protection and the like in the prior art are effectively solved, and the circulation and fresh-keeping effects of fresh-cut China roses are improved.

The present application relates to a skin cell soothing and repairing composition containing artemisia and its preparation method and application, and belongs to the technical field of cosmetics. The present application finds that only by inhibiting the upstream anti-inflammatory pathway of the NF-kappa B pathway, the anti-inflammatory effect is limited, while inhibiting the NF-kappa B pathway, the downstream transmission chain is blocked, and the anti-inflammatory effect is significantly enhanced. Based on this, the present application inhibits the upstream anti-inflammatory pathway by artemisia extract and jasminum officinale extract, reduces the recruitment and infiltration of inflammatory cells, blocks the downstream transmission chain, and synergistically improves the anti-inflammatory effect. In addition, the present application cooperates oat kernel oil, jasmine flower oil and squalane, on the one hand, improves the solubility of fat-soluble active substances, on the other hand, participates in the repair, stabilization and optimization of the lipid structure of the skin cuticle, synchronously opens the skin fat-soluble channel, and more efficiently transports active substances, thereby realizing excellent soothing, repairing and stabilizing effects.

The application relates to the cosmetic technical field, and particularly discloses a loose powder containing Schizosaccharomyces ferment filtrate and a preparation method thereof. The loose powder containing Schizosaccharomyces ferment filtrate comprises A phase, B phase, C phase and D phase; the A phase comprises the following raw materials in percentage by mass: 3-44 parts of a filler; the B phase comprises the following raw materials in percentage by mass: 1-50 parts of Schizosaccharomyces ferment, 0.1-0.5 parts of a preservative and 0.1-0.5 parts of a cool-feeling agent; the C phase comprises the following raw materials in percentage by mass: 1-10 parts of 1,1,1-trimethyl-N-(trimethylsilyl) silane amine pretreated silica; and the D phase comprises the following raw materials in percentage by mass: 0.5-1.5 parts of a preservative and 0.1-0.5 parts of a humectant. The loose powder containing Schizosaccharomyces ferment filtrate has the advantages of long-acting moisturizing, oil control and makeup fixing, can relieve makeup oxidation and has whitening.

The application belongs to the technical field of biology and particularly relates to application of ISL2 in regulating melatonin synthesis. The application discloses that ISL2 can be combined with a melatonin synthesis rate-limiting enzyme AANAT gene promoter, so as to regulate activity of the AANAT promoter, further regulate an expression amount of AANAT, and finally realize regulation of melatonin synthesis.

The application relates to the technical field of gas flow bed coal gasification production processes, and provides a crude coal gas pre-washing device which comprises a water washing tower, a crude coal gas pipe is arranged in the middle of the water washing tower, an extension pipe is connected to the crude coal gas pipe in the water washing tower, the extension pipe extends to below the liquid level, a plurality of gas distribution holes are arranged on the extension pipe, and the gas distribution holes are located below the liquid level. The crude coal gas is introduced into black water through the extension pipe for washing, meanwhile, the crude coal gas is divided into a plurality of small gas flows through the gas distribution holes, so that the crude coal gas is fully mixed with the black water, the washing effect of the crude coal gas is ensured, the water washing tower tray load is reduced, the tower tray is prevented from being scaled and the synthetic gas is prevented from being mixed with ash and water, and the service life is prolonged. Meanwhile, the main road gas volume of the extension pipe can be reduced, the pump cavitation caused by the bottom black water pump suction bubbles is reduced, the pump outlet flow low interlock system shutdown and other abnormal accidents are avoided. The scheme has few structures, does not change the existing water washing tower, has low cost and good safety effect.