1667results about How to "Inhibit synthesis" patented technology

This invention relates to novel pharmaceutically useful compositions that bind to a biological molecule, having improved circulatory half-life, increased avidity, increased affinity, or multifunctionality, and methods of use thereof. The present invention provides a pseudo-antibody comprising an organic moiety covalenty coupled to at least two target-binding moieties, wherein the target-binding moieties are selected from the group consisting of a protein, a peptide, a peptidomimetic, and a non-peptide molecule that binds to a specific targeted biological molecule. The pseudo-antibody of the present invention may affect a specific ligand in vitro, in situ and / or in vivo. The pseudo-antibodies of the present invention can be used to measure or effect in an cell, tissue, organ or animal (including humans), to diagnose, monitor, modulate, treat, alleviate, help prevent the incidence of, or reduce the symptoms of, at least one condition.

A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

The invention relates to a pharmaceutical composition consisting of or containing cyclosporin A and alpha -tocopherol or one of the derivatives thereof.

A method for preserving and processing nucleic acids located within a blood sample is disclosed, wherein a blood sample containing nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the integrity and amount of cellular nucleic acids that can be identified and tested while avoiding contamination of the isolated nucleic acids with cell-free nucleic acids.

The active hypolipemic components in 40 Chinese-medicinal materials and their relative medicines are disclosed. Said active components can suppress the activity of fatty acid synthetase and the differentiation from profat cells to fat cells and activate the activity of acyl-CoA synthetase. Said medicines feature high effect and low toxic by-effect.

An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.

Method of identifying a cognate nucleotide (i.e., the “next correct nucleotide”) for a primed template nucleic acid molecule. In some embodiments, an ordered or random array of primed target nucleic acids characterized by different cognate nucleotides can be evaluated using a single imaging step to identify different cognate nucleotides for a collection of different primed template nucleic acid molecules. An optional incorporation step can follow the identifying step. A polymerase different from the ones used in the binding and examination steps can be used to incorporate a nucleotide, such as a reversible terminator nucleotide, preliminary to identification of the next cognate nucleotide.

The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and / or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.

The invention provides a composition and a method for lowering blood serum cholesterol levels or for preventing elevated blood serum cholesterol levels, as well as suitable composition comprising (a) one or more phytosterols and / orphytostanols or a mixture thereof capable of reducing cholesterol absorption in the intestine, (b) a composition capable of inhibiting cholesterol biosynthesis, and (c) a composition capable of increasing cholesterol metabolism, wherein at least one of compositions b. and c. is preferably derived from plants.

In an audio coding system, an encoding transmitter represents encoded spectral components as normalized floating-point numbers. The transmitter provides first and second control parameters that may be used to transcode the encoded spectral parameters. A transcoder uses first control parameters to partially decode the encoded components and uses second control parameters to re-encode the components. The transmitter determines the second control parameters by analyzing the effects of arithmetic operations in the partial-decoding process to identify situations where the floating-point representations lose normalization. Exponents associated with the numbers that lose normalization are modified and the modified exponents are used to calculate the second control parameters.

The present invention concerns compositions and methods for the introduction of specific genetic changes in endogenous genes of the cells of an animal. The genetic changes are effected by oligonucleotides or oligonucleotide derivatives and analogs, which are generally less than about 100 nucleotides in length. The invention provides for macromolecular carriers, optionally incorporating ligands for clathrin coated pit receptors. In one embodiment the ligand is a lactose or galactose and the genetic changes are made in hepatocytes. By means of the invention up to 40% of the copies of a target gene have been changed in vitro. Repair of mutant genes having a Crigler-Najjar like phenotype and Hemophilia B phenotype were observed.

In an audio coding system, an encoding transmitter represents encoded spectral components as normalized floating-point numbers. The transmitter provides first and second control parameters that may be used to transcode the encoded spectral parameters. A transcoder uses first control parameters to partially decode the encoded components and uses second control parameters to re-encode the components. The transmitter determines the second control parameters by analyzing the effects of arithmetic operations in the partial-decoding process to identify situations where the floating-point representations lose normalization. Exponents associated with the numbers that lose normalization are modified and the modified exponents are used to calculate the second control parameters.

The invention relates to a process for the in vivoproduction of a target RNA in a host cell comprising providing a microorganism comprising a vector comprising a DNA sequence encoding the target RNA, fermenting the host cell and allowing the DNA sequence to be transcribed into the target RNA, and obtaining the target RNA from the host cell. The process is characterised in that the host cell comprises a vector comprising a DNA sequence encoding an RNase inhibitor. The invention also relates to the vector used in such process and the host cell comprising such vector as well as the use of the vector and the host cell in such process.

The invention relates to a method for carrying out surface modification on a quantum dot / rod, preparation of a photosynthetic catalyst as well as a system and a method. The surface modification is carried out on the quantum dot / rod, and the quantum dot / rod is simply and rapidly used as a carrier; and metal ions which are used as catalytic activity sites are further key-bonded and assembled on the surface of the quantum dot to prepare a high-activity photosynthetic hydrogen-producing photocatalyst and prepare hydrogen. According to the method for carrying out the surface modification on the quantum dot / rod, the preparation of the photosynthetic catalyst as well as the system and the method disclosed by the invention, high-efficiency photosynthetic hydrogen production can be realized by the simple, low-cost and stable photocatalyst; complicated and unstable catalytic activity centers which is natural or artificially-simulated and the like do not need so as to avoid complicated synthesis and system construction; and the method disclosed by the invention has the advantages of efficient reaction, simplicity in reaction, low cost and practical applicability, and provides an effective way for effectively reducing the photosynthetic hydrogen production cost and improving the catalytic efficiency.

An FFT unit performs an FFT process on high-frequency-eliminated, pitch-shifted voice data for one frame. A time scaling unit calculates a frequency amplitude, a phase, a phase difference between the present and immediately preceding frames, and an unwrapped version of the phase difference for each channel from which the frequency component was obtained by the FFT, detects a reference channel based on a peak one of the frequency amplitudes, and calculates the phase of each channel in a synthesized voice based on the reference channel, using results of the calculation. An IFFT unit processes each frequency component in accordance with the calculated phase, performs an IFFT process on the resulting frequency component, and produces synthesized voice data for one frame.

The invention discloses a maca functional beverage and a preparation method thereof. The maca functional beverage contains maca, citric acid and water. The preparation method comprises the following steps of crushing maca into fine powder, mixing the maca fine powder and other raw materials, and carrying out homogenization treatment on the mixture. The maca functional beverage has high biologically-active substance content, is conducive to direct absorption of functional and nutritive components by drinkers, realizes complete combination of maca functionality, naturality and safety and is a novel health food and drink having a plurality of functions.

The present invention pertains to a method for treatment of allergic diseases by administering a natriuretic hormone peptide (NHP), or a nucleic acid sequence encoding NHP, to a patient in need thereof. In another aspect, the present invention concerns an expression vector comprising a nucleic acid sequence encoding NHP. In another aspect, the present invention concerns a host cell genetically modified with a nucleic acid sequence encoding NHP. In another aspect, the present invention concerns a pharmaceutical composition comprising NHP or a nucleic acid sequence encoding NHP and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to novel fragments of atrial natriuretic peptide (ANP) exhibiting bronchodilatory and anti-inflammatory activity, and isolated nucleic acid sequences encoding the fragments.

The invention relates to the technical field of biology and in particular relates to a specific target polypeptide self-assembled nanoparticle. The nanoparticle is prepared from a hydrophobic anti-tumor drug with a therapeutic dosage and an amphipathic polypeptide which covers the periphery of the hydrophobic anti-tumor drug through a self-assembling manner, wherein the amphipathic polypeptide is a target peptide which can be used for specifically targeting a epidermal growth factor receptor of a tumor cell; a terminal N of the target peptide is coupled with a hydrophobic functional molecule. After the nanoparticle targets the tumor cell, the target peptide is exposed; the nanoparticle targets the tumor cell and enters the tumor cell through receptor-mediated endocytosis, and the drug is released to inhibit DNA (Deoxyribonucleic Acid) synthesis and repairing; the nanoparticle has dual killing effects on the tumor cells and the growth of the tumor cell is inhibited. The amphipathic polypeptide does not generate a covalent bond in a self-assembling process and no reverse reaction is caused; the specific target polypeptide self-assembled nanoparticle is used for treating tumors and has the advantages of no toxin and good biocompatibility.

An extract of mulberry twigs is dislcosed, which can be used to prepare the food or the medicine to cure hyperuricemia and gout diseases. The said extract is prepared from mulberry twigs through extracting in solvent (aqueous solution of alcohol, chloroform, acetone, etc) at 10-100 deg.C more than one time, mergint the liquid extracts, recovering solvent, regulating pH value to 7.5-9.5, centrifugal separation to obtain supernatant, regulating pH value to 4-6, deposition, water washing wand drying. Several other approaches for purifying it are also disclosed.

Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and / or PAOD.

The present invention provides compositions comprising a chimeric molecule comprising a cytotoxin that inhibits protein synthesis and an agent that inactivates an anti-apoptotic BCL-2 family member protein and methods of inhibiting the growth of or promoting the apoptosis of an aberrantly proliferating cell population by co-administering the chimeric molecule and the agent that inactivates an anti-apoptotic BCL-2 family member protein.

The present invention relates to the reduction or attenuation a specific composition has on immunological tissue-destructive conditions associated with specific autoimmune diseases. The composition includes a long chain primary aliphatic alcohol, and one or more of three cofactors: a D Vitamin, a B12 Vitamin, a coenzyme Q, and an omega-3 fatty acid. The composition functions coordinately to modify multiple autoimmune disease risk factors and symptoms associated with the autoimmune disease. The compounds work in a synergistic manner to attenuate tissue-destructive inflammation.

The present invention provides for a topical composition that includes a topical carrier and an adenosine deaminase inhibitor. Suitable specific adenosine deaminase inhibitors include, e.g., deoxycoformycin (dCF), deoxyadenosine (dAdo), cladrabine (CdA), fludarabine (F-Ara-A), cytrabine (Ara-C), and thioguanine. The present invention also provides for a method to treat lymphocyte mediated skin diseases and to alleviate symptoms associated with such skin diseases. The method includes topically administering the composition to a mammal in need of such treatment. The present invention also provides for kits and syringe systems that include the adenosine deaminase inhibitor.

This invention provides a compound of the following formula:or the pharmaceutically acceptable salts thereof wherein R1 is H or C1-4 alkyl; R2 is C(=L')R3 or So2R4; Y is a direct bond or C1-4 alkylene; L and L' are independently oxygen or sulfur; Q is selected from the following: C1-6 alkyl, halo-substituted C1-4 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted phenyl or naphthyl, optionally substituted 5 or 6-membered monocyclic aromatic group;R3 is -OR6, -NR7R8, N(OR1)R7 or a group of formula:Z is a direct bond, O, S or NR5; R4 is C1-6 alkyl, halo-substituted C1-4 alkyl, optionally substituted phenyl or naphthyl; R5 is C1-4 alkyl or halo-substituted C1-4 alkyl; R6 is C1-4 alkyl C3-7 cycloalkyl, C1-4 alkyl-C3-7 cycloalkyl, halo-substituted C1-4 alkyl, optionally substituted C1-4 alkyl-phenyl or phenyl; R7 and R8 are each selected from the following: H, optionally substituted C1-6 alkyl, optionally substituted C3-7 cycloalkyl, optionally substituted C1-4 alkyl-C3-7 cycloalkyl, and optionally substituted C1-4 alkyl-phenyl or phenyl; X is each selected from halo, C1-4 alkyl, halo-substituted C1-4 alkyl, OH, C1-4 alkoxy, halo-substituted C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di-(C1-4 alkyl)amino and CN; n is 0, 1, 2 or 3; and r is 1, 2 or 3. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

A novel cathepsin K crystalline stucture is identified. Also disclosed are methods of identifying inhibitors of this protease and methods of inhibiting cathepsin K using inhibitors with certain structural, physical and spatial characteristics.

The invention relates to health preserving tea which is prepared from lohanguo siraitia fruit, boat-fruited sterculia seed, rose, red date, dwarf lilyturf root tuber, wolfberry fruit, aloe, licorice root, lotus plumule, eucommia bark, black tea, Americans ginseng, ganoderma lucidum spore powder, tuber fleeceflower root, poria cocos, Chinese yam rhizome, Cassia occidentalis, cassia seed, mulberry leaves, Lithocarpus polystachyus wild tea, raw hawthorn, Grifola frondosa and Antrodia camphorate. The health preserving tea has the effects of clearing and nourishing throat, invigorating qi, tonifying kidney, tranquilizing mind, improving sleeping, caring skin, removing toxic materials, losing weight, and the like, does not contain artificial sugar, and has sweet taste and esthetic color. The health preserving tea can effectively enhance immunity of human body, and has simple production process, convenience in consumption and moderate price, and is very suitable for modern sub-health people for conditioning and health preserving.

A charcoal-ash interfusion multistage burning method and system for rotary kiln refuse gasification relates to environmental protection technical field. The method comprises: loading the broken and compacted refuse in a kiln-gas gasifier; implementing partial heat release gasification after the refuse counter current contacting heating with high temperature fume; generating waste gas with lower calorific value entering a high temperature melt type combustion furnace; separating metal monomer by sorting unit after elimination of solid bottoms in the kiln-gas gasifier; grinding other charcoal components, pneumatically conveying them in the high temperature melt type combustion furnace, and making them melting and burning with gas; discharging water quenched slag; and chilling discharged fume after heat recovery by a waste heat boiler, and discharging it into the air via dry purification. The invention not only fundamentally eliminates fly ash source which acts as a catalyst in dioxin and heavy metal formation reaction, but also increases efficiency of carbon conversion of system combustion without increasing energy consumption basically. At the same time, the invention also implements metal resource monomer recovery.

The invention discloses a household garbage classified gasification system with rotary kiln gasification and plasma fusion capability. The household garbage classified gasification system comprises a rubbish feeder, a rotary kiln type pyrolysis vaporizer, a metal sorting machine, a crusher, a high-temperature cyclone separator, an ash hopper, an ash feeder, a plasma fusion furnace and an air preheater; household garbage is sequentially subjected to the pyrolysis gasification, metal sorting and crushing of the rotary kiln type pyrolysis vaporizer and the further gasification treatment of the plasma fusion furnace; the low-temperature rotary kiln vaporizer and the high-temperature plasma fusion furnace can be effectively combined, and the ash generated by pyrolysis and gasification of the rotary kiln vaporizer is fused by virtue of taking plasma torch as a high-quality heat source; the household garbage classified gasification system can effectively take the heat of synthesis gas and the gas fume generated by the fusion furnace as an outer heat source of the rotary kiln vaporizer so as to heat the air entering in the plasma fusion furnace, the comprehensive energy use efficiency is improved, and the secondary pollution problem of dioxin and heavy metal is avoided.

A method for treating skin, reducing oxidative damage to a skin cell, reducing lipoxygenase (LO) activity in a skin cell, reducing cyclooxygenase (COX) activity in a skin cell, reducing tumor necrosis factor alpha (TNF-α) in a skin cell, or reduction matrix metalloproteinase enzyme activity in a skin cell comprising contacting skin or a skin cell with an aromatic skin-active ingredient.