497 results about "Lacceroic acid" patented technology

The invention discloses tetrapeptide KA4 with an anti-fatigue function as well as a preparation method and application of the tetrapeptide KA4, and belongs to the technical field of biology. The tetrapeptide KA4 is screened from pacific salmon protamine enzymatic hydrolysate, the amino acid sequence is KYPA, and the tetrapeptide KA4 has strong binding capacity with KEAP1, AMPK and LDH, can significantly reduce the serum lactic acid content of a fatigue model mouse and significantly increase the load swimming time of the fatigue model mouse, has an anti-fatigue function, and can be applied to development of functional food for relieving fatigue.

The invention discloses an environment-friendly electrolyte for anodic oxidation of titanium and titanium alloy workpieces and an electrolytic coloring method. The electrolyte comprises 8-12 parts of lactic acid, 5-10 parts of sodium tartrate, 2-5 parts of sodium bicarbonate and the balance of deionized water. The electrolytic coloring method comprises the steps of pretreatment, anodic oxidation coloring and aftertreatment. The pretreatment comprises alkali washing oil removal, water washing and laser treatment; and an electrolyte mixed by 8-12 parts of lactic acid, 5-10 parts of sodium tartrate, 2-5 parts of sodium bicarbonate and the balance of deionized water is used for anodic oxidation coloring. The post-treatment comprises sealing treatment and drying. According to the technical scheme, the technical problems that the anodic oxidation coloring technology is completely free of fluorine, low in toxicity and safe to operate, and the oxidation waste liquid is free of pollution and easy to treat can be solved, existing pretreatment steps can be simplified, and meanwhile uniform coloring is achieved.

The invention discloses a high-stability hydroxysteroid dehydrogenase mutant, a co-immobilized enzyme construction method and application. According to the invention, a site-directed mutant library is constructed based on computer-aided design, and mutants with significantly improved thermal stability and greatly improved catalytic efficiency compared with wild type mutants are obtained through screening; meanwhile, a co-immobilized enzyme construction method based on electrostatic adsorption and chemical crosslinking is established, the hydroxysteroid dehydrogenase mutant and lactic dehydrogenase are co-immobilized, the co-immobilized enzyme can still keep high activity under high substrate concentration, and the conversion rate is still maintained to be 90% or above after 30 batches of co-immobilized enzyme are repeatedly used. And an important foundation is laid for industrial application of the hydroxysteroid dehydrogenase.

The invention relates to the technical field of medical data analysis, in particular to a sepsis prediction system based on deep learning. The system comprises a sepsis risk assessment module, a capillary barrier injury analysis module, a myocardial inhibition analysis module and a sepsis prediction module, and blood lactic acid concentration data of a patient are obtained through a lactic acid analyzer; acquiring oxygenation state data of a patient through a blood gas analyzer, and performing sepsis risk assessment according to the oxygenation state data of the patient and the blood lactic acid concentration data of the patient, so as to obtain sepsis risk data; obtaining a lung structure image through a high-resolution chest CT; performing alveolar feature extraction according to the lung structure image to obtain alveolar data; according to the pulmonary alveolar data, capillary barrier injury analysis is carried out, so that capillary barrier injury data is obtained; an echocardiogram is obtained by an echocardiograph. The sepsis prediction accuracy is improved based on a medical data analysis technology.

The invention discloses a high-temperature-resistant and salt-resistant fracturing fluid and a preparation method thereof, and relates to the technical field of oil field fracturing fluids. When the high-temperature-resistant and salt-resistant fracturing fluid is prepared, sodium 3-chloro-2-hydroxypropane sulfonate, N, N-dimethylacrylamide and ethylene glycol react to prepare a quaternized solid product, and then the quaternized solid product reacts with 1-bromooctadecane to prepare an amphoteric hydrophobic monomer; guar gum powder reacts with 3-(1-naphthyloxy)-1, 2-epoxypropane to prepare naphthyloxy functionalized guar gum, and then the naphthyloxy functionalized guar gum, acrylamide and an amphoteric hydrophobic monomer are subjected to initiated polymerization through ceric ammonium nitrate to prepare modified guar gum; enabling zirconium oxychloride octahydrate, titanium chloride, lactic acid, ethanediamine and glycerol to react to prepare an organic zirconium cross-linking agent; and finally, mixing the modified guar gum, an organic zirconium cross-linking agent, sodium thiosulfate, sodium bromate, a surfactant and water to prepare the high-temperature-resistant and salt-resistant fracturing fluid. The high-temperature-resistant and salt-resistant fracturing fluid prepared by the invention has excellent high-temperature resistance and salt resistance.

The invention relates to the technical field of microorganisms, in particular to saccharomyces cerevisiae CEC NW94 and application thereof. The invention provides the Saccharomyces cerevisiae CEC NW94, and the Saccharomyces cerevisiae CEC NW94 is used for brewing the wine, so that the contents of glycerol and lactic acid can be increased, and the yield of volatile acid can be reduced; the synthesis of volatile substances such as ethyl 2-methylbutyrate, isoamyl alcohol and linalool is promoted, and the generation of acetic acid is inhibited, so that the wine presents complex aroma of black fruits, mushrooms and the like, and the odor of herbaceous plants, herbal medicines, vinegar and the like is effectively reduced; in addition, the strain can improve the umami of the grape wine, and improve the aroma purity, the aroma concentration, the wine body, the aftertaste and the complexity. According to the method, the flavor substances of the dry red wine are controlled through a microbial metabolism regulation and control technology, and a new technical scheme is provided for high-quality wine production.

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

The invention relates to the technical field of insulin resistance reversal, in particular to a composition with an insulin resistance reversal component and a preparation method thereof.The composition comprises quercetin, procyanidine, malic acid, magnesium carbonate, zinc lactate and cereals, fasting blood glucose, fasting insulin and an insulin resistance index can be reduced through synergistic interaction of all the components, and the insulin resistance index can be reduced; according to the traditional Chinese medicine composition, the insulin sensitivity index is improved, and the problems that in the prior art, traditional Chinese medicine compositions are complex in component, effective components capable of reversing insulin resistance and the synergistic mechanism are unclear, and the content of the effective components in the same medicine is inconsistent due to the influence of the growth environment, so that the treatment effect is unpredictable are solved.

The invention relates to the fields of epigenetic regulation and tumor treatment, and aims to evaluate that the cell distribution of the mutant is consistent with that of H3 by constructing Bas-2B (H3K9R) and Bas-2B (H3K18R) stably transfected cell strains and analyzing the cell positioning condition of the H3K9R / H3K18R mutant through an immunofluorescence technique. According to the present invention, a Western blotting technology is adopted to detect the H3K9 / H3K18 lactic acid modification level of Bas-2B (H3K9R) and Bas-2B (H3K18R) cells compared to control cells so as to verify the influence of the H3K9R / H3K18R mutant on the H3K9 / H3K18 lactic acid modification; after Bas-2B (H3K9R), Bas-2B (H3K18R) cells and control cells of the Bas-2B (H3K9R) and the Bas-2B (H3K18R) cells are subjected to nickel compound exposure treatment, the influence of the H3K9R / H3K18R mutant on the nickel compound induced lung cancer is evaluated through a soft agar cloning formation experiment. An AGS cell line stably transfecting H2BK16R is constructed, and the cell localization condition of the H2BK16R mutant is analyzed through an immunofluorescence technology. According to the present invention, a Westernbloting technology is adopted to detect the lactic acid modification level of AGS (H2BK16R) cells so as to verify the influence of the H2BK16R mutant on the H2BK16 lactic acid modification; the influence of the H2BK16R on the malignant proliferation ability of the gastric cancer is researched through a soft agar clone formation experiment.

The invention discloses an application of beta-alanine in preparation of a medicine for treating pulmonary arterial hypertension. In-vivo and in-vitro pharmacological experiments prove that beta-alanine can inhibit lactic acid-mediated histone milk acylation modification and hypoxia-induced phenotypic transformation of PASMCs (Polyaspartic Sulfonate Molecules); the hemodynamics and pulmonary artery vascular remodeling of the PAH mouse are improved. The beta-alanine can inhibit phenotypic transformation of PASMCs and reverse pulmonary artery vascular remodeling which is a key pathological change in the pulmonary hypertension generation process, has huge potential in treatment of pulmonary hypertension, and has good application prospects and high clinical application value.

The invention relates to a polygonatum sibiricum probiotic compound preparation with an aging delaying effect and application thereof. The compound preparation comprises a polygonatum sibiricum extract and a probiotic composition, the bacterial strains in the probiotic composition comprise a combination of a bifidobacterium animalis subsp. Lactis BLa36 bacterial strain, a bifidobacterium longum BL21 bacterial strain, a bifidobacterium adolescentis BAC30 bacterial strain, a lactobacillus plantarum Lp90 bacterial strain, a lactobacillus casei LC89 bacterial strain, a bifidobacterium breve BBr60 bacterial strain and a pediococcus acidilactici CCFM7902 bacterial strain. After the rhizoma polygonati component and the probiotic component are combined for use, the rhizoma polygonati component and the probiotic component have potential synergistic effects in the aspects of improving the intestinal flora structure, regulating the intestinal environment, delaying senescence, reducing inflammation-related symptoms and the like. Moreover, further, various probiotic strains are compounded and combined for use, so that the capability of a related compound preparation in the aspect of delaying various symptoms of senescence can also be improved in a combined manner.

The invention relates to a lotus leaf polyphenol extract with a blood fat reducing effect as well as a preparation method and application of the lotus leaf polyphenol extract. The preparation method comprises the following steps that firstly, lotus leaf powder is pretreated through low-temperature plasmas, the treatment time is 400 W, the treatment power is 6 min, then a deep eutectic solvent serves as an extraction solvent, high-pressure auxiliary extraction is conducted on the pretreated lotus leaf powder, the ultrahigh pressure is 1.0 MPa, and the extraction time is 30 min; performing centrifugal filtration, concentration and drying to obtain a lotus leaf polyphenol extract; wherein the eutectic solvent is choline chloride-lactic acid-glycerol-water in a volume ratio of 1: 1: 1: 1. According to the method, the polyphenol compounds in the lotus leaves are extracted by combining the eutectic solvent with the plasma and high-pressure extraction technology, and compared with a traditional method, the method has the advantages of being simple, efficient, high in yield, free of organic reagent pollution, high in safety, easy to industrialize and the like. The lotus leaf polyphenol extract prepared by the invention has good pancreatic lipase inhibitory activity, which indicates that the lotus leaf polyphenol extract has the effect of reducing blood fat. The lotus leaf extract disclosed by the invention has great development value in the field of obesity, and also can promote high-value utilization of lotus leaf resources.

The invention belongs to the field of pet food processing, and relates to a functional pet food for regulating intestinal health and a preparation method thereof. The functional pet food can increase MTL content in dog serum in a physiological range, reduce DAO activity and D-lactic acid and LPS content in dog serum, improve intestinal mucosa barrier function, and significantly improve dog intestinal health. The functional pet food can shorten gastrointestinal transmission time and effectively improve constipation. The functional pet food disclosed by the invention has a good effect in the aspects of treating diarrhea and constipation, and has a two-way regulation effect in regulating intestinal flora imbalance. The components of the raw materials have a synergistic effect, the nutrition is balanced, the preparation method is simple, the palatability is optimally designed, and the metabolic characteristic is free of burden, so that pets can safely take the feed for a long time, a convenient and efficient preventive health management scheme is provided for family pet raising, and the feed has a relatively good commercial application prospect.

The present disclosure relates to the field of livestock farming, and specifically provides a feeding method for gilts in batch for promoting onset of puberty and alleviating estrus disorder of gilts, which is aiming at an industrial problem that a large number of gilts are culled due to delayed puberty onset or estrus disorder. The method includes: feeding, prior to onset of puberty for gilts with vitamin A combined with lactic acid; and performing, subsequent to the puberty onset of gilts, estrus synchronization treatment and insemination treatment on the gilts. By applying vitamin A combined with lactic acid, the present disclosure alleviates the delayed puberty onset or estrus disorder of the gilts, reduces the feeding duration and feeding cost of the gilts, facilitates synchronous estrus treatment of the gilts.

The invention discloses a female private part composite bacteriostatic agent and a preparation method thereof, and relates to the technical field of female care products. The female private part compound bacteriostatic agent is prepared from the following raw materials in percentage by weight: 0.2 to 0.5 percent of cortex phellodendri extract, 0.2 to 0.5 percent of radix sophorae flavescentis extract, 0.05 to 0.1 percent of tanshinone extract, 0.05 to 0.1 percent of fructus cnidii extract, 0.5 to 1.2 percent of cranberry extract, 0.02 to 0.04 percent of chlorhexidine gluconate, 0.02 to 0.04 percent of chlorhexidine acetate, 0.08 to 0.2 percent of glycerol monolaurate, 0.3 to 0.9 percent of lactic acid, 0.3 to 0.9 percent of probiotic microcapsules, 1 to 2 percent of compound amino acid surfactant, 0.1 to 0.5 percent of vitamin E and the balance of water. 0.1-0.3% of a preservative, 2-4% of glycerol and the balance of water. The antibacterial health-care product has an excellent antibacterial effect, and can effectively regulate the micro-ecological balance of the private parts of women.

A system includes a wearable device including a base adapted to be connected to skin of a patient. An electrochemical sensor is connected to the base. The electrochemical sensor includes a sensor medium responsive to lactate. The electrochemical sensor is in fluid connection with one or more transdermal fluid paths in connection with the base. The one or more transdermal fluid paths are configured to be placed in fluid connection with the subdermal fluid of the patient. The system further includes electronic circuitry including at least one measurement system in operative connection with the electrochemical sensor to measure a variable providing a measure of change in at least one property of the sensor medium which is dependent upon the presence of lactate in the subdermal fluid.

The invention belongs to the technical field of medicines, and particularly relates to application of indole-3-lactic acid in preparation of medicines for treating diabetes and complications. A db / db mouse is utilized to simulate the pathological process of human diabetes, the db / db mouse is orally administered with indole-3-lactic acid, and after the db / db mouse orally administered with indole-3-lactic acid, the blood glucose and blood fat of the diabetic mouse can be reduced, the cardiac function impairment of the diabetic mouse is improved, and the brain cognitive dysfunction of the diabetic mouse is improved. It is proved that the indole-3-lactic acid has a treatment effect on diabetes and cardiovascular and cerebrovascular complications thereof.

To provide a composition for hair and / or scalp.SOLUTION: A composition for hair and / or scalp comprising (A) polyvinylpyrrolidone, (B) lactic acid and / or a salt thereof, and (C) diammonium aminoethylthiosuccinate.SELECTED DRAWING: None

The invention discloses application of lycium barbarum polysaccharide in preparation of a medicine for inhibiting methylamphetamine-induced nerve injury, and relates to the technical field of biological medicines. It is found and proved that lycium barbarum polysaccharide can inhibit methylamphetamine-induced nerve injury, and the effect is remarkable. From the aspect of cell survival, the survival rate of the microglial cells pretreated by the lycium barbarum polysaccharide after METH stimulation is obviously improved. In the molecular mechanism, the lycium barbarum polysaccharide can effectively lower the protein expression level of the METH-induced pyroptosis marker, the content of inflammatory factors IL-1beta and IL-18 can be reduced, and the release of lactic dehydrogenase is reduced. The result shows that the lycium barbarum polysaccharide can alleviate inflammatory response by inhibiting NLRP3 / ASC pathway mediated microglial cell pyroptosis, thereby inhibiting METH-induced nerve injury. The invention provides a new direction for developing METH neurotoxicity intervention medicines.

The invention discloses a catalyst for preparing lactide through condensation of lactic acid and a preparation method and application thereof, the preparation method comprises the following steps: S1, adding an activator N-isopropyl-N-methylpropan-2-amine into a proline solution, then adding a zinc salt, reacting to obtain proline zinc, adding a catalyst, and reacting to obtain proline zinc; wherein the mass ratio of the N-isopropyl-N-methylpropane-2-amine to the proline is (4 to 6): 100, and the mass ratio of the N-isopropyl-N-methylpropane-2-amine to the proline is ( And S2, mixing and reacting zinc proline and the SAPO-11 molecular sieve in a solvent according to a mass ratio of 1: (0.8-1.2) to obtain the zinc proline / SAPO-11 composite material. According to the material, a commercialized and easily available SAPO-11 molecular sieve is used as a catalyst carrier, and zinc proline activated by N-isopropyl-N-methylpropan-2-amine is loaded. The material can catalyze lactic acid polymerization to prepare lactide. Compared with a traditional catalyst, the catalytic material has the advantages that the coking yield can be reduced to be within 5%, and a small amount of generated coke is not adhered to a container and is easy to clean.

The invention discloses a method for determining nitrosamine impurity N-nitrosociprofloxacin in ciprofloxacin lactate, and relates to the field of substance detection methods, the method adopts a liquid chromatography-mass spectrometry technology, and the liquid chromatography condition comprises that a mobile phase is a mixture of a formic acid solution with the concentration of 0.08%-0.12% and acetonitrile, and the volume ratio of the formic acid solution to the acetonitrile is (45-55): (45-55). According to the present invention, the liquid chromatography (LC) technology and the mass spectrometry (MS) technology are combined, such that the efficient separation ability of the liquid chromatography and the high sensitivity detection ability of the mass spectrometry are combined, the detection sensitivity and the detection accuracy are significantly improved, and the strict requirements of drug quality control and safety are met.

A poly(lactic-co-glycolic acid)-containing resin composition according to exemplary embodiments may include a poly(lactic-co-glycolic acid) (PLGA) polymer, a zinc-containing ionomer (Zn ionomer) and an ethylene terpolymer. The PLGA polymer may be 65 wt % or more and less than 100 wt % based on a total weight of the poly(lactic-co-glycolic acid)-containing resin composition.

The embodiment of the application discloses a kind of bone repair materials and its preparation method and application.The preparation method includes: poly-L-lactic acid and barium titanate are added in hexafluoroisopropanol, fully stir, obtain PLLA / BTO suspension;Poly-L-lactic acid is dissolved in hexafluoroisopropanol, then add catalpol, obtain PLLA / CA solution;With the PLLA / BTO suspension as shell material, PLLA / CA solution as core material, coaxial electrospinning is carried out, to obtain composite nanomaterial, then remove solvent, obtain the bone repair material.The bone repair material of the application not only has higher anti-osteoporosis activity, but also can improve the stability of the material (low degradation rate, long complete degradation time) and enhance the piezoelectric effect, achieve excellent osteoporosis bone defect repair effect;Preparation process is relatively simple and convenient, key technology is easy to control, and manufacturing cost is lower.

The present disclosure provides methods of treating an immune-mediated disease in a subject in need thereof. The present disclosure provides methods of treating atopic dermatitis in a subject in need thereof. The present disclosure provides methods of treating moderate to severe atopic dermatitis in a subject in need thereof. The present disclosure provides a method of treating atopic dermatitis (AD) in a subject in need thereof, the method comprises selecting a subject suffering from AD and having an elevated level relative to a control of at least one biomarker selected from the group consisting of thymus activation regulatory chemokine (TARC), interleukin-5 (IL-5), eosinophilic granulocyte count, and lactic dehydrogenase (LDH).

The application relates to the frontiers of nanomaterials and drug screening fields, and discloses a fluorescent probe material for drug screening and a drug screening method. The fluorescent probe material realizes screening of anticancer drug efficacy of a to-be-detected drug by detecting the concentration of an NAD+ (nicotinamide adenine dinucleotide) active marker of lactate dehydrogenase, the fluorescent probe material comprises an A agent and a B agent, the A agent is a covalent organic framework material loaded with carbon dots with reducibility, and is denoted as COF@CDs, and the B agent is a transition metal hydride; the transition metal hydride can make NAD+ hydrogenated and reduced into NADH in the presence of the COF@CDs; the product after hydrogen loss of the transition metal hydride can be combined with the COF@CDs, and the COF@CDs can emit fluorescence under excitation light, and the fluorescence is quenched.

The invention relates to the technical field of biological medicines, in particular to application of panthenol-cytochrome c reductase core protein 2 lactic acid modification as a therapeutic target in preparation of drugs for treating sepsis cardiomyopathy. The invention discloses a key effect of Uqcrc2 K109 site lactic acid modification in SIC and application of the Uqcrc2 K109 site lactic acid modification as a therapeutic target. The Uqcrc2-K109 is found to be a therapeutic target of the SIC through molecular biology methods such as proteomics analysis, lactylation omics analysis and co-immunoprecipitation, and the function of a mitochondrial respiratory chain complex III is recovered in a targeted manner by regulating and controlling the lactylation level of the Uqcrc2-K109, so that a new strategy is provided for treatment of the SIC.

SOLVENT COMPOSITIONS The present invention relates to a solvent composition for solvent-based paints or other coatings characterized in that it comprises a combination of dimethyl glutarate and at least one other compound selected from isobutyl acetate, ethyl lactate, dimethyl 2-methylglutarate, 2-methyltetrahydrofuran, ethyl acetate, cyclopentyl methyl ether, dithoxymethane, dimethyl carbonate, dimethyl succinate, benzyl alcohol, dimethyl adipate, and glyceryl triacetate. Fig. 1

The invention discloses Leishan fish sauce sour essence as well as a preparation method and application thereof. The leishan fish sauce acid essence is prepared from ethyl acetate, absolute ethyl alcohol, ethyl isovalerate, ethyl hexanoate, isoamyl alcohol, furfuryl alcohol, ethyl lactate, ethyl caprylate, acetic acid, diethyl succinate, methyl salicylate, ethyl benzoate, ethyl laurate, hexanoic acid, phenethyl alcohol, 4-methyl guaiacol, ethyl myristate, ethyl palmitate, ethyl oleate, capsicum oleoresin, ethyl phenylacetate and ginger oil. And lactic acid, glycerol triacetate, ocimene, ethyl isovalerate, ethyl butyrate, anethole and phenylacetaldehyde. The Leishan fish sauce sour essence disclosed by the invention is soft and harmonious in overall fragrance, natural and vivid, still has stable flavor characteristics at high temperature, can make up the problem of flavor deficiency in sour soup products, realizes accurate reproduction and controllable release of composite fragrance, improves the standardization level of products, and effectively improves the preference degree of consumers.

The invention aims to provide a method for determining the content of main effective components of Xiaoyianmi cream and an application of the method, and aims to solve the technical problem that a Xiaoyianmi cream compound preparation is lack of efficient and accurate multi-component synchronous quality evaluation due to complex components of the Xiaoyianmi cream compound preparation. According to the method, a chromatography-tandem mass spectrometry technology is adopted, chromatography and mass spectrometry conditions are optimized, and an analysis method for simultaneously determining six components such as phloridine, piperlonguminine, piperine, N-trans-feruloyltyramine, DL-B-phenyllactic acid and pinocembrin is established. The determination method provided by the invention has the advantages of being simple and convenient to operate, high in sensitivity, good in repeatability, high in accuracy and the like, can realize rapid and synchronous determination of multi-index components in the Xiaoyi honey paste, and provides reliable technical support for quality control and standardization of the Xiaoyi honey paste.

A storage stable aqueous solution composition comprising vancomycin or a pharmaceutically acceptable salt thereof, at a concentration of 25-75 mg / mL; D-lactic acid or a pharmaceutically acceptable salt thereof; a cosolvent selected from propylene glycol and a mixture of propylene glycol and glycerol; and an inorganic salt containing a metal cation.