835 results about "Lacceroic acid" patented technology

The invention discloses tetrapeptide KA4 with an anti-fatigue function as well as a preparation method and application of the tetrapeptide KA4, and belongs to the technical field of biology. The tetrapeptide KA4 is screened from pacific salmon protamine enzymatic hydrolysate, the amino acid sequence is KYPA, and the tetrapeptide KA4 has strong binding capacity with KEAP1, AMPK and LDH, can significantly reduce the serum lactic acid content of a fatigue model mouse and significantly increase the load swimming time of the fatigue model mouse, has an anti-fatigue function, and can be applied to development of functional food for relieving fatigue.

The invention discloses an environment-friendly electrolyte for anodic oxidation of titanium and titanium alloy workpieces and an electrolytic coloring method. The electrolyte comprises 8-12 parts of lactic acid, 5-10 parts of sodium tartrate, 2-5 parts of sodium bicarbonate and the balance of deionized water. The electrolytic coloring method comprises the steps of pretreatment, anodic oxidation coloring and aftertreatment. The pretreatment comprises alkali washing oil removal, water washing and laser treatment; and an electrolyte mixed by 8-12 parts of lactic acid, 5-10 parts of sodium tartrate, 2-5 parts of sodium bicarbonate and the balance of deionized water is used for anodic oxidation coloring. The post-treatment comprises sealing treatment and drying. According to the technical scheme, the technical problems that the anodic oxidation coloring technology is completely free of fluorine, low in toxicity and safe to operate, and the oxidation waste liquid is free of pollution and easy to treat can be solved, existing pretreatment steps can be simplified, and meanwhile uniform coloring is achieved.

The invention discloses a high-stability hydroxysteroid dehydrogenase mutant, a co-immobilized enzyme construction method and application. According to the invention, a site-directed mutant library is constructed based on computer-aided design, and mutants with significantly improved thermal stability and greatly improved catalytic efficiency compared with wild type mutants are obtained through screening; meanwhile, a co-immobilized enzyme construction method based on electrostatic adsorption and chemical crosslinking is established, the hydroxysteroid dehydrogenase mutant and lactic dehydrogenase are co-immobilized, the co-immobilized enzyme can still keep high activity under high substrate concentration, and the conversion rate is still maintained to be 90% or above after 30 batches of co-immobilized enzyme are repeatedly used. And an important foundation is laid for industrial application of the hydroxysteroid dehydrogenase.

The invention provides a polypeptide and application thereof in preparation of a medicine for preventing and / or treating alcoholic liver injury. The polypeptide is safe and free of side effects, can remarkably reduce the content of malondialdehyde (MDA), improve the activity of superoxide dismutase (SOD), improve the content of glutathione (GSH), reduce the activity of glutamic-pyruvic transaminase (ALT), reduce the activity of aspartate transaminase (AST) and reduce the activity of lactic dehydrogenase (LDH), and is very suitable for preparing the medicine for preventing and / or treating the alcoholic liver injury.

The invention discloses a composition for treating insomnia. Comprising probiotic compounds: lactobacillus plantarum, bifidobacterium lactis, lactobacillus crispatus, lactobacillus acidophilus, lactobacillus rhamnosus, bifidobacterium bifidum, lactobacillus reuteri, lactobacillus casei, lactobacillus bulgaricus, lactobacillus fermentum, lactobacillus gasseri, lactococcus lactis, bifidobacterium longum, lactobacillus salivarius, bifidobacterium breve, streptococcus thermophilus and lactobacillus paracasei; lactobacillus helveticus; and traditional Chinese medicine components and prebiotics. Probiotics are matched with traditional Chinese medicines with homology of medicine and food, and corresponding prebiotics are supplemented, so that the balance of intestinal flora can be adjusted and information transmission between intestines and cranial nerves can be promoted through the synergistic effect of the probiotics and the corresponding prebiotics, and then gastrointestinal inflammation, ulcer, helicobacter pylori infection, constipation and insomnia are treated or improved; and treating or improving spleen and stomach disharmony, liver qi stagnation, excessive heart fire, fire excess from yin deficiency, heart-kidney disharmony caused by emotion, pressure, diseases and the like, and insomnia caused by the symptoms.

The invention relates to the technical field of microorganisms, in particular to application of pediococcus acidilactici ZJUIDS13 in improvement of liver diseases, including improvement of alcoholic liver diseases and improvement of fatty liver diseases related to metabolic dysfunction. The pediococcus acidilactici ZJUIDS13 has relatively strong capability of protecting liver injury induced by alcohol, and can improve the states of liver injury and lipid metabolism disorder caused by high fat diet.

The invention relates to the technical field of medical data analysis, in particular to a sepsis prediction system based on deep learning. The system comprises a sepsis risk assessment module, a capillary barrier injury analysis module, a myocardial inhibition analysis module and a sepsis prediction module, and blood lactic acid concentration data of a patient are obtained through a lactic acid analyzer; acquiring oxygenation state data of a patient through a blood gas analyzer, and performing sepsis risk assessment according to the oxygenation state data of the patient and the blood lactic acid concentration data of the patient, so as to obtain sepsis risk data; obtaining a lung structure image through a high-resolution chest CT; performing alveolar feature extraction according to the lung structure image to obtain alveolar data; according to the pulmonary alveolar data, capillary barrier injury analysis is carried out, so that capillary barrier injury data is obtained; an echocardiogram is obtained by an echocardiograph. The sepsis prediction accuracy is improved based on a medical data analysis technology.

The invention discloses a method for extracting active ingredients in pollen typhae based on a natural eutectic solvent, and belongs to the technical field of active substance extraction. By screening the natural eutectic solvent and optimizing preparation parameters, the invention provides the method for extracting the active components in the pollen typhae by using the natural eutectic solvent, and solves the problems of low extraction rate of the active components in the pollen typhae and the like in the prior art. According to the method, proline-lactic acid (the molar ratio is 1: 3) is used as a natural eutectic solvent, and the extraction efficiency of total active substances (polyphenol, flavone and alkaloid) in the pollen typhae reaches 167.9 mg / g of pollen typhae powder; the extraction of quercetin reaches 0.41 mg / g of pollen typhae powder, and the extraction effect is far better than that of conventional water extraction and alcohol extraction.

The invention relates to the technical field of dental restoration materials, in particular to a bacteriostatic dental restoration composite film and a preparation method thereof. The oral cavity restoration composite film is composed of an upper-layer antibacterial film, a middle-layer polycaprolactone fiber film and a lower-layer bone restoration film. The upper-layer antibacterial film is prepared from the following components in parts by weight: 3 to 4 parts of cinnamon essential oil, 0.5 to 1 part of xanthan gum, 0.5 to 1 part of seed meal protein, 0.1 to 0.15 part of tannic acid, 5 to 7 parts of silk fibroin, 1 to 1.5 parts of polylactic acid, 0.6 to 1 part of chitosan, 1 to 1.5 parts of polyvinyl alcohol and 1.5 to 2.5 parts of glycerol; the lower-layer bone repair membrane is prepared from the following raw materials in parts by weight: 2 to 3 parts of nano-hydroxyapatite, 3 to 5 parts of citric acid, 6 to 9 parts of lactic acid, 3 to 4 parts of tyrosine, 1 to 2 parts of glycollic acid, 2 to 3 parts of casein, 0.2 to 0.3 part of hyperoside and 1 to 2 parts of gelatin.

The present disclosure provides methods of treating an immune-mediated disease in a subject in need thereof. The present disclosure provides methods of treating atopic dermatitis in a subject in need thereof. The present disclosure provides methods of treating moderate-to-severe atopic dermatitis in a subject in need thereof. The present disclosure provides a method of treating atopic dermatitis (AD) in a subject in need thereof, comprising selecting a subject having AD and an elevated level of at least one biomarker selected from the group consisting of thymus and activation-regulated chemokine (TARC), interleukin-5 (IL-5), eosinophil count, and lactate dehydrogenase (LDH) relative to a control.

The present disclosure provides methods of treating an immune-mediated disease in a subject in need thereof. The present disclosure provides methods of treating atopic dermatitis in a subject in need thereof. The present disclosure provides methods of treating moderate-to-severe atopic dermatitis in a subject in need thereof. The present disclosure provides a method of treating atopic dermatitis (AD) in a subject in need thereof, comprising selecting a subject having AD and an elevated level of at least one biomarker selected from the group consisting of thymus and activation-regulated chemokine (TARC), interleukin-5 (IL-5), eosinophil count, and lactate dehydrogenase (LDH) relative to a control.

Provided here is use of Lacticaseibacillus paracasei or postbiotics thereof for the manufacture of a pharmaceutical or a food composition for generating a cholic acid conjugated to tryptophan. The Lacticaseibacillus paracasei or the postbiotics thereof can be used for preventing and / or treating a metabolic disease, or for promoting GLP-1 and / or insulin production, or for maintaining healthy blood glucose level, maintaining healthy lipid level and / or controlling body fat.

The invention relates to an itching relieving and soothing skin care lotion and a preparation method thereof. The skin care lotion is prepared from the following raw materials in parts by weight: 10-20 parts of grease, 1-3 parts of a nonionic emulsifier, 0.1-1 part of a skin feeling regulator, 0.5-2 parts of a first skin conditioner, 1-5 parts of a second skin conditioner, 0.1-1 part of an antioxidant, 1-2 parts of a humectant, 0.1-1 part of a pH regulator and 70-85 parts of water, the first skin conditioner contains a citrus peel extract and carboxymethyl chitosan, and the second skin conditioner contains hydroxyphenyl propionamide benzoic acid, stearyl glycyrrhetinate, menthol lactate, alpha-bisabolol and guaiazulene. The skin care lotion does not contain diphenhydramine hydrochloride and other substances with safety risks, is safe and mild, has remarkable itching relieving and soothing effects, and is safe and non-irritant to infants and children; during preparation, heating is little, and the activity of active substances can be reserved to the maximum extent so as to effectively ensure the itching relieving and relieving effects of the product.

The invention discloses a high-temperature-resistant and salt-resistant fracturing fluid and a preparation method thereof, and relates to the technical field of oil field fracturing fluids. When the high-temperature-resistant and salt-resistant fracturing fluid is prepared, sodium 3-chloro-2-hydroxypropane sulfonate, N, N-dimethylacrylamide and ethylene glycol react to prepare a quaternized solid product, and then the quaternized solid product reacts with 1-bromooctadecane to prepare an amphoteric hydrophobic monomer; guar gum powder reacts with 3-(1-naphthyloxy)-1, 2-epoxypropane to prepare naphthyloxy functionalized guar gum, and then the naphthyloxy functionalized guar gum, acrylamide and an amphoteric hydrophobic monomer are subjected to initiated polymerization through ceric ammonium nitrate to prepare modified guar gum; enabling zirconium oxychloride octahydrate, titanium chloride, lactic acid, ethanediamine and glycerol to react to prepare an organic zirconium cross-linking agent; and finally, mixing the modified guar gum, an organic zirconium cross-linking agent, sodium thiosulfate, sodium bromate, a surfactant and water to prepare the high-temperature-resistant and salt-resistant fracturing fluid. The high-temperature-resistant and salt-resistant fracturing fluid prepared by the invention has excellent high-temperature resistance and salt resistance.

The present invention relates to the technical field of cosmetics, and discloses a whitening and freckle-removing essence and a preparation method thereof. The whitening and freckle-removing essence is formed by mixing additives such as nicotinamide, EDTA, L-lactic acid, citric acid, baicalein inclusion complex, etc. The baicalein inclusion complex has a coated structure. Since the skin surface carries a negative charge and the coating layer of the baicalein inclusion complex contains chitosan, it can be adsorbed on the skin surface through electrostatic action, producing a sustained-release effect, and then targeted release, so as to improve the whitening effect of the essence. In addition, after being encapsulated, baicalein can have good compatibility with other substances in the formula. Moreover, the linolenic fatty acid chain in the structure of the chitosan derivative has excellent antioxidant, anti-inflammatory and other effects, which can reduce the phenomenon of scar formation on the skin due to inflammation.

The present disclosure relates to the technical field of microsphere drug preparations, in particular to an octreotide acetate sustained-release microsphere as well as a preparation method therefor and use thereof. The preparation method includes the following steps: S1, dissolving a polylactic acid-co-glycolic acid copolymer in a first organic solvent to prepare an oil phase 1; and dissolving octreotide acetate in a second organic solvent to prepare an oil phase 2; S2, adding the oil phase 2 into the oil phase 1 under stirring conditions to obtain a suspension containing octreotide acetate; S3, transferring the suspension to an aqueous phase, and performing emulsifying to obtain a semi-cured drug-loaded microsphere; and S4, transferring the semi-cured drug-loaded microsphere to a curing phase, and removing the solvents to obtain the octreotide acetate sustained-release microsphere.

The present technology provides a process for extracting acrylic acid from an aqueous feedstock that includes acrylic acid and one or more byproducts from catalytic dehydration of lactic acid to acrylic acid (e.g., acetol and / or 2,3-pentanedione), where the process steps include: contacting the aqueous feedstock with an extractant to obtain a raffinate and a solvent phase; separating the raffinate from the solvent phase; and removing the extractant from the solvent phase to obtain an extraction product, where the extractant is water-immiscible and has a distribution coefficient for acrylic acid (Kd, acrylic acid) from about 1.2 to about 10.0 (weight basis).

The invention relates to the technical field of microorganisms, in particular to saccharomyces cerevisiae CEC NW94 and application thereof. The invention provides the Saccharomyces cerevisiae CEC NW94, and the Saccharomyces cerevisiae CEC NW94 is used for brewing the wine, so that the contents of glycerol and lactic acid can be increased, and the yield of volatile acid can be reduced; the synthesis of volatile substances such as ethyl 2-methylbutyrate, isoamyl alcohol and linalool is promoted, and the generation of acetic acid is inhibited, so that the wine presents complex aroma of black fruits, mushrooms and the like, and the odor of herbaceous plants, herbal medicines, vinegar and the like is effectively reduced; in addition, the strain can improve the umami of the grape wine, and improve the aroma purity, the aroma concentration, the wine body, the aftertaste and the complexity. According to the method, the flavor substances of the dry red wine are controlled through a microbial metabolism regulation and control technology, and a new technical scheme is provided for high-quality wine production.

The invention relates to the field of cosmetics, and discloses ceramide liposome and application thereof.The ceramide liposome is prepared from, by mass, 1.5-3 parts of ceramide NP, 1-3 parts of octyldodecanol, 0.5-2 parts of caprylic / capric triglyceride, 11-18 parts of hydrogenated lecithin, 2-6 parts of sucrose stearate, 3-7 parts of polyglycerol-10 oleate and 25-35 parts of glycerinum, and the balance is water. 0.5-8 parts of 1, 2-pentanediol, and the balance of water. The ceramide liposome provided by the invention has good stability at least at 40 DEG C, is not easy to cause lactic acid pricking pain and allergy after being smeared on skin, and can be used for sensitive skin; the skin care product can reduce skin transdermal moisture loss, maintain skin cutin moisture, reduce skin heme content, improve skin gloss, relieve skin dryness, relieve skin redness and improve skin fineness, and has the effects of moisturizing, repairing and relieving.

Provided is a Bifidobacterium lactis. The Bifidobacterium lactis is Bifidobacterium animalis subsp. lactis BL-11, and the preservation number of the Bifidobacterium animalis subsp. lactis BL-11 is CGMCC No. 20847. The provided Bifidobacterium animalis subsp. Lactis can improve intestine metabolism disorder and normalize the composition of intestine microbiome so as to improve height, suppresses obesity, promote infant and youth physical development and mental development, and prevent and treat mental disorders, said mental disorders including anxiety, depression, attention-deficit / hyperactivity disorder, autism, schizophrenia, hepatic encephalopathy, anorexia, Tourette syndrome, and Asperger syndrome.

The invention belongs to the technical field of anhydrous emulsions, and discloses an anhydrous self-emulsifying drug-loaded emulsion based on a deep eutectic solvent and a preparation method thereof.The preparation method comprises the following steps that 1, betaine and a hydrogen bond donor are mixed, the deep eutectic solvent is prepared through a mixed heating method, a drug is dissolved in the deep eutectic solvent, and a drug solution is prepared; the hydrogen bond donor is levulinic acid or lactic acid; (2) mixing Tween 80 and Span 80 according to a mass ratio of (1-2): 1 to obtain a surfactant, adding absolute ethyl alcohol as a co-emulsifier, adding isopropyl myristate, and uniformly stirring and mixing to obtain a dispersion liquid; and (3) dropwise adding the drug solution in the step (1) into the dispersion liquid in the step (2), and stirring at the same time to finally form the anhydrous self-emulsifying drug-loaded emulsion. According to the invention, the loading capacity, the stability and the bioavailability of the medicine can be obviously improved; in addition, the efficiency of transdermal drug delivery of the emulsion is high, and the emulsion can be applied to skin external preparations.

The invention relates to the technical field of insulin resistance reversal, in particular to a composition with an insulin resistance reversal component and a preparation method thereof.The composition comprises quercetin, procyanidine, malic acid, magnesium carbonate, zinc lactate and cereals, fasting blood glucose, fasting insulin and an insulin resistance index can be reduced through synergistic interaction of all the components, and the insulin resistance index can be reduced; according to the traditional Chinese medicine composition, the insulin sensitivity index is improved, and the problems that in the prior art, traditional Chinese medicine compositions are complex in component, effective components capable of reversing insulin resistance and the synergistic mechanism are unclear, and the content of the effective components in the same medicine is inconsistent due to the influence of the growth environment, so that the treatment effect is unpredictable are solved.

The invention relates to the technical field of medical gel, and particularly discloses a sustained-release gel preparation for endometrial repair and a preparation method of the sustained-release gel preparation. Keratinocyte factor sustained-release microspheres containing keratinocyte factor-glucan particles and lactic acid-glycolic acid copolymer shells are constructed around keratinocyte factors, and the keratinocyte factor sustained-release microspheres are loaded by hyaluronic acid hydrogel containing polylysine, collagen and silk fibroin to form the sustained-release gel preparation for endometrial repair. The sustained-release gel preparation has the effect of promoting proliferation of human endometrial cells, can repair endometrial injury, promote injury healing and prevent uterine cavity adhesion, and has important significance in treating endometrial injury and improving physical and psychological health of women.

The invention discloses a method for extracting light-color lignin based on a ternary complex solvent and application of the light-color lignin in sunscreen cream, and belongs to the field of lignin separation and high-value utilization thereof. The method comprises the following specific steps: mixing choline chloride, lactic acid and acetic anhydride to prepare a ternary composite solvent, heating plant fiber raw materials and the ternary composite solvent to react, and extracting the light-color lignin. According to the method disclosed by the invention, the molar ratio of choline chloride to lactic acid to acetic anhydride is 1: 1: (3-5), and the extracted lignin is faint yellow and shows a lighter color compared with other disclosed technologies. And after the prepared light-color lignin is mixed with the sunscreen cream according to the doping amount of 8wt%, the sunscreen index SPF reaches 38 and is close to the requirements of commercial sunscreen cream, and the light-color lignin does not generate a stain phenomenon on the skin when being smeared and used, has certain practical value and effectively expands the application potential of the lignin in the fields of cosmetics, ultraviolet absorbers and the like.

The invention relates to the technical field of lubricants, in particular to a low-osmotic-pressure hyaluronic acid lubricant and a preparation method thereof. The low-osmotic-pressure hyaluronic acid lubricant disclosed by the invention is prepared from the following materials in parts by weight: 88.35 to 92.97 parts of purified water, 4 to 6 parts of modified polyvinyl alcohol, 2 to 5 parts of 1, 2-propylene glycol, 0.1 to 1 part of sodium hyaluronate, 0.01 to 0.1 part of aloe extract, 0.01 to 0.1 part of snail stock solution, 0.01 to 0.1 part of herba centellae extract, 0.05 to 0.06 part of phenoxyethanol, 0.45 to 0.55 part of ethylhexylglycerin and 0.01 to 0.03 part of lactic acid. The lubricant obtained by the preparation method disclosed by the invention can effectively improve the lubricating property and prolong the service life; by means of accurately controlling the dosage and proportion of each component, optimizing the preparation process and the like, multiple advantages of low osmotic pressure, moisturizing and lubrication, skin friendliness, stability, safety and the like are realized, the requirements of different crowds can be met, and comfortable use experience is provided.

The invention relates to the fields of epigenetic regulation and tumor treatment, and aims to evaluate that the cell distribution of the mutant is consistent with that of H3 by constructing Bas-2B (H3K9R) and Bas-2B (H3K18R) stably transfected cell strains and analyzing the cell positioning condition of the H3K9R / H3K18R mutant through an immunofluorescence technique. According to the present invention, a Western blotting technology is adopted to detect the H3K9 / H3K18 lactic acid modification level of Bas-2B (H3K9R) and Bas-2B (H3K18R) cells compared to control cells so as to verify the influence of the H3K9R / H3K18R mutant on the H3K9 / H3K18 lactic acid modification; after Bas-2B (H3K9R), Bas-2B (H3K18R) cells and control cells of the Bas-2B (H3K9R) and the Bas-2B (H3K18R) cells are subjected to nickel compound exposure treatment, the influence of the H3K9R / H3K18R mutant on the nickel compound induced lung cancer is evaluated through a soft agar cloning formation experiment. An AGS cell line stably transfecting H2BK16R is constructed, and the cell localization condition of the H2BK16R mutant is analyzed through an immunofluorescence technology. According to the present invention, a Westernbloting technology is adopted to detect the lactic acid modification level of AGS (H2BK16R) cells so as to verify the influence of the H2BK16R mutant on the H2BK16 lactic acid modification; the influence of the H2BK16R on the malignant proliferation ability of the gastric cancer is researched through a soft agar clone formation experiment.

The invention relates to a biodegradable film material as well as a preparation method and application thereof, and belongs to the technical field of compositions of high-molecular compounds. The biodegradable film material is prepared from the following components in parts by weight: 39 to 85.6 parts of PBAT resin, 2 to 10 parts of PLA resin, 10 to 40 parts of calcium carbonate, 2 to 10 parts of an inorganic opening auxiliary agent and 0.2 to 1 part of an organic opening auxiliary agent, the molar content of D-lactic acid in the PLA resin is less than or equal to 6%; the particle size D50 of the calcium carbonate is 1.5-2.5 [mu] m; the particle size D50 of the inorganic anti-blocking agent is 1-5 [mu] m. The biodegradable film material not only can be used for high-speed film blowing, but also has good opening performance, high factor value and excellent falling dart impact performance.

The invention discloses an application of beta-alanine in preparation of a medicine for treating pulmonary arterial hypertension. In-vivo and in-vitro pharmacological experiments prove that beta-alanine can inhibit lactic acid-mediated histone milk acylation modification and hypoxia-induced phenotypic transformation of PASMCs (Polyaspartic Sulfonate Molecules); the hemodynamics and pulmonary artery vascular remodeling of the PAH mouse are improved. The beta-alanine can inhibit phenotypic transformation of PASMCs and reverse pulmonary artery vascular remodeling which is a key pathological change in the pulmonary hypertension generation process, has huge potential in treatment of pulmonary hypertension, and has good application prospects and high clinical application value.

The invention relates to a polygonatum sibiricum probiotic compound preparation with an aging delaying effect and application thereof. The compound preparation comprises a polygonatum sibiricum extract and a probiotic composition, the bacterial strains in the probiotic composition comprise a combination of a bifidobacterium animalis subsp. Lactis BLa36 bacterial strain, a bifidobacterium longum BL21 bacterial strain, a bifidobacterium adolescentis BAC30 bacterial strain, a lactobacillus plantarum Lp90 bacterial strain, a lactobacillus casei LC89 bacterial strain, a bifidobacterium breve BBr60 bacterial strain and a pediococcus acidilactici CCFM7902 bacterial strain. After the rhizoma polygonati component and the probiotic component are combined for use, the rhizoma polygonati component and the probiotic component have potential synergistic effects in the aspects of improving the intestinal flora structure, regulating the intestinal environment, delaying senescence, reducing inflammation-related symptoms and the like. Moreover, further, various probiotic strains are compounded and combined for use, so that the capability of a related compound preparation in the aspect of delaying various symptoms of senescence can also be improved in a combined manner.

The invention provides an organoid basic culture medium and a method for maintaining and promoting organoid growth, and the organoid basic culture medium comprises a basic culture medium and an additive, the additives comprise taurine sodium 3-hydroxybutyrate, taurine, sodium hypoxanthate, creatinine, L-ornithine, urea, L-sodium lactate, putrescine dihydrochloride, anhydrous citric acid, ethanolamine, N-acetylglycine, alpha ketoglutaric acid, formic acid, malic acid, malonic acid, succinic acid, uric acid, ammonium metavanadate, manganese dichloride, sodium selenite, creatine, glycerol and uridine. Anhydrous sodium acetate and para aminobenzoic acid. When the organ-like basic culture medium is used for treating the organ-like, the activity of the organ-like can be effectively maintained, and basic nutrition and metabolism requirements of the organ-like can be provided, so that the organ-like has the advantages of high activity, fast proliferation and long-term stable passage, and is suitable for various types of organs and wide in application.