40 results about "Selenol" patented technology

The invention provides a polymer nano hydrogel. A polymer matrix of the polymer nano hydrogel comprises a block copolymer with the structure shown in a formula (I) or a formula (II) in the specifications, and the block copolymer is subjected to internal crosslinking through Se-Se bond molecules. The invention further provides a preparation method of the polymer nano hydrogel. In the polymer nano hydrogel provided in the invention, the polymer matrix comprises a poly(L-glutamic acid) chain block containing carboxyl, the carboxyl is sensitive to a pH value and ion strength in a water solution, and the Se-Se bond is sensitive to both reductant and oxidant: in an oxidant environment, the Se-Se bond breaks to generate selenic acid and realize decrosslinking, and in an reductant environment, the Se-Se bond is reduced into selenol to realize decrosslinking. Therefore, the polymer nano hydrogel provided in the invention is simultaneously sensitive to the pH value, the ion strength, the oxidant and the reductant, and can realize quick drug release in target cells so as to improve the curative effect of the drugs.

Compositions are provided for the topical treatment of cancer consisting of lotions, creams, sprays, suppositories or slow-release transdermal patches containing lipid-soluble, skin-penetrating organic selenium compounds in combination with inert carriers in therapeutically effective amounts of selenium compound. The selenium compounds are medium linear chain dialkyl diselenides and precursors such as alkyl selenols. Preferred compositions employ R—Se—Se—R compounds where R is from 6 to 8 carbon atoms, and most specifically di-n-hexyl diselenide. Commonly used carriers may be purified hydrocarbon fractions, oils, with or without added fat-soluble vitamins, water and emulsifying agents.

The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E. coli TrxR with K_i of 0.14 μM and 0.46 μM, respectively. E. coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter pylori was also sensitive to ebsulfur.

Disclosed are compounds having the formula

wherein R¹ is hydrogen, an alkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an aralkyl group, or ═O,

• • R² is an alkyl group, an aryl group, a cycloalkyl group, an alkenyl group, an alkynyl group, or an aralkyl group, or the pharmaceutically acceptable salt or ester thereof. Also disclosed are methods of using the compounds.

A process for producing copper selenide nanoparticles by effecting conversion of a nanoparticle precursor composition comprising copper and selenide ions to the material of the copper selenide nanoparticles in the presence of a selenol compound. Copper selenide-containing films and CIGS semiconductor films produced using copper selenide as a fluxing agent are also disclosed.

The invention discloses a two-dimension transition metal sulphur group compound and a preparation method and device thereof. The preparation method comprises the following steps that a liquid state transition metal source is taken, and a substrate is covered by the liquid state transition metal source; a carrier gas is utilized to convey a liquid state sulphur group source to the position of the substrate, wherein the sulphur group source is mercaptan, selenol or telluromercaptan; and heating reaction is conducted in an enclosed environment, and the two-dimension transition metal sulphur groupcompound is acquired. According to the preparation method for the two-dimension transition metal sulphur group compound, the liquid state transition metal source and liquid state sulphur group sourceare utilized and serve as reaction precursors, it is easy to construct a stable precursor concentration field growth system through control over the concentration of the reaction precursors; thus uniform nucleation and growth of the transition metal sulphur group compound is promoted so that density distribution of the morphology, thickness and crystal domain dimension of the transition metal sulphur group compound material acquired through preparation on the substrate is more uniform; and the preparation method has outstanding optical and electrical properties and a broad application prospect.

A synthesis of and use for L-Se-methylselenocysteine as a nutriceutical is described, based upon the knowledge that L-Se-methylselenocysteine is less toxic than L-selenomethionine towards normal cells. The synthesis proceeds by mixing N-(tert-butoxycarbonyl)-L-serine with a dialkyl diazodicarboxylate and at least one of a trialkylphosphine, triarylphosphine, and phosphite to form a first mixture that includes N-(tert-butoxycarbonyl)-L-serine β-lactone. Methyl selenol or its salt is mixed with the N-(tert-butoxycarbonyl)-L-serine β-lactone to form a second mixture that includes N-(tert-butoxycarbonyl)-Se-methylselenocysteine. The tert-butoxycarbonyl group is removed from the N-(tert-butoxycarbonyl)-Se-methylselenocysteine to form L-Se-methylselenocysteine. This synthesis significantly improves the manufacturability, manufacturing efficiency, and utility of this naturally occurring rare form of organic-selenium. L-Se-methylselenocysteine formed, for example, in this manner may be used as a nutriceutical for supplementation into the diets of humans or animals for various beneficial purposes, such as, for example, to prevent or reduce the risk of developing cancer.

The main purpose of the present invention is to provide a method for producing a selenol with high yield without causing the fluctuations in yield among production lots. The purpose can be achieved by a method for producing a selenol, which comprises steps (1) and (2): (1) a step of reacting a Grignard reagent represented by general formula (1) with selenium to produce a reaction solution containing a selenomagnesium halide represented by general formula (2); and (2) a step of adding the reaction solution produced in step (1) mentioned above to an acidic solution dropwisely to produce a selenol represented by general formula (3).

A diselenide synthesizing method relates to the technical field of chemical synthesis. The method employs selenium powder as a selenylation reagent and anhydrous sodium sulfite as an additive, so that the method has many advantages. The method is free of any metal reagents. Because that selenium is a necessary microelement of living bodies and is metabolizable in human body, the method is ecological-friendly. In addition, the method is carried out under a neutral environment, so that the method is less in corrosion on devices and a reaction system is durable. The method does not generate a selenol intermediate which has stink smell, so that the method is suitable for industrial production, is low in cost and short in route, is mild in reaction conditions and is simple in reaction operations.

The invention reasonably designs and prepares a polycarbonate polymer, namely, PMPC-Dns, modified through 2,4-dinitrobenzene sulfonyl so as to detect selenocysteine in living bodies. The compound can wrap fluorescent medicine doxorubicin (DOX) and selectively respond to Sec and a selenol compound without being interfered with by biological mercaptan, amine and alcohol. Formation of micelle, responses of Sec, cytotoxicity of probes and medicine release of the Sec responses are researched. The PMPC-Dns probes can be applied to imaging of endogenous Sec in cervical cancer tissue and hela cells under the physiological conditions, and the PMPC-Dns probes can conduct imaging and release medicine wrapped in the probes at the same time. The work opens up a road for understanding the effects of Sec in physiology and pathology systems and tumor xenograft model systems, and a method is provided for controlled releases of hydrophobicity molecules in target molecules in the biomedicine application.

The invention relates to small photosensitizers, their process of preparation and uses of the compounds in optical imaging and photodynamic therapy. The invention provides a compound of formula (I), a derivative or a salt thereof Wherein R1 is selected from the group consisting of amines, anilines, phenols, thiophenols, selenols and aryl groups; R2 and R3 independently are H or halogen; R4 is selected from the group consisting of H, nitre and cyano: and R5 and R6 independently are either absent or oxygen or methyl.

The invention discloses a preparation method of high-optical-purity D- or L-selenomethionine. The preparation method comprises the following steps: by taking D- or L-methionine as initial raw materials and diethyl sulfate or halogenated alkyl acid or derived esters as alkylation reagents, generating sulfonium salt, desulfurizing and closing ring under acidic conditions, to produce alpha-amino-gama-butyrolactone halate, having addition reaction to alpha-amino-gama-butyrolactone halate with methyl selenol salt and opening ring, acidifying with organic acid, and recrystallizing to obtain D- or L-selenomethionine. The chemical purity of the product is more than or equal to 99%, and the high optical purity is more than or equal to 99%. The preparation method is low-cost and easily available in raw materials, simple in steps and easy to operate, simple in reaction conditions, and suitable for large-scale production.