15 results about "Selenol" patented technology

The invention discloses an anti-fouling road marking composition based on a hydrophobic nanometer material and a preparation method of the anti-fouling road marking composition, and belongs to the technical field of road marking materials. Comprising the following raw materials: selenol modified silicon dioxide, phosphonate modified nano titanium dioxide, a selenol-urethane acrylate hybrid, phosphonate-fluorosilicone urethane acrylate, a waterborne polyurethane dispersion and the like. The preparation method comprises the following steps: dispersing the nanofiller at a high speed, mixing the modified polymer and the film-forming substance, stirring, adjusting the viscosity and the like. The composition has a super-hydrophobic characteristic, and can effectively resist attachment of oil stains and dust; the modified polymer and the nanofiller are strongly combined through covalent bonds, and the adhesive force is excellent; meanwhile, good weather resistance is achieved, and aging is not prone to occurring after long-term use. The paint can be widely applied to road marking, and the anti-pollution performance and the service life of the marking are improved.

The present invention provides a method for catalytic synthesis of organic semiconductor g-C3N4 ( E The invention relates to the technical field of organic synthesis. The invention uses selenium sulfonate and alkyne as reaction substrates, uses graphite phase carbon nitride g-C3N4 prepared by thermal polycondensation of urea as catalyst, and reacts freely in an organic solvent under light conditions to obtain ( E )-vinyl selenol sulfone compounds. The present invention is ( E The synthesis of )-vinyl selenolsulfone compounds provides a new pathway for preparing alkylaryl alkynes using this synthetic route, which offers mild reaction conditions and high yields. This invention utilizes the conveniently tunable and recyclable organic semiconductor g-C3N4 as a heterogeneous photocatalyst to achieve atom transfer radical addition reactions of alkynes in a metal-free environment, enabling precise control of the reaction's stereoselectivity and regioselectivity, and has promising application potential.

The invention discloses a selenol-alkynyl click (SYC) chemically mediated cell surface rapid functional modification method, which mainly comprises the following steps: firstly, introducing selenol functional molecules into the surface of a living cell, so that the surface of the living cell is modified with an active selenol group to form a selenolated cell surface, and then carrying out surface modification on the selenolated cell surface to obtain a selenol-alkynyl click (SYC) chemically mediated cell surface; then, a biocompatible material carrying an alkynyl functional group is in contact with the surface of the selenolated cell, and covalent coupling of the biocompatible material and the surface of the selenolated cell is realized through a selenol-alkynyl click reaction under a physiological compatible condition, so that the cell is endowed with new properties or functions; and a novel method is provided for research on cell surface functionalization and regulation of specific interaction between cells. The application range of selenol-alkynyl click chemistry in the field of biomedicine is expanded, an existing cell surface chemical modification tool box is further enriched, and a new tool is provided for the fields of clinical diagnosis, tumor immunotherapy, basic cell biology research and the like.

A method for forming a protective cap layer on a metal layer of a semiconductor substrate is described. The metal layer is deposited using pulses of a metal precursor and reactants to form a metal layer having a reactive surface. The number of cycles can be in the range of 1 to 10 cycles, or 2 to 5 cycles, or 2 to 100 cycles. Next, the metal layer is exposed to a long-chain precursor (e.g., primary amine, alcohol, thiol, phosphine, selenol) and the metal precursor to form a protective cap layer on the metal layer. The number of cycles can be in the range of 1 to 10 cycles, or 2 to 5 cycles, depending on the desired thickness of the protective cap layer.

The invention relates to small, conjugatable, orthogonal and tunable fluorophores for imaging of small bioactive molecules. The invention further relates to processes for the preparation of the compounds, and uses of the compounds in therapeutic, diagnostic, surgery and analytical applications. The invention provides a compound of formula (I), a derivative or a salt thereof. Wherein X is selected from the group consisting of NH, O, S, SeR5R6, CR7R8; R1 is selected from the group consisting of amines, alcohols, thiols, thiophenols, selenols, selenophenols and aryl groups; R2 and R3 are independently H or a halogen; R4 tis either H, nitro or cyano; R5 is either absent or methyl or oxygen; R6 is either absent or methyl or oxygen; and R7 and R8 are independently selected from the group consisting of linear or cyclic alkyl groups containing halogen, amino, cyano or carboxylic ester substituents, and alkyl aryl groups.

The invention discloses stable polyfunctional selenol and a preparation method thereof. The method can solve the problems that selenol is poor in stability and extremely easy to oxidize in air, and high-purity selenol cannot be prepared. The selenium-containing compound has good dynamic characteristics, optical activity and biological activity, and has a wide application prospect. Although selenol has reactivity similar to that of hydroxyl and sulfydryl, the selenol is extremely unstable and is extremely easy to oxidize in air, high-purity selenol cannot be prepared, and polymerization reaction and the like needing quantitative functional group ratio cannot be carried out. The polyfunctional selenol disclosed by the invention is stable in structure, simple in preparation method and high in product purity, and can be stored for a long time; besides, stable selenol with different chemical structures and different functional group numbers can be obtained by replacing different reactants, polyfunctional selenol with different properties such as flexibility and rigidity can be prepared according to requirements, and a new thought is provided for development of organic selenium chemistry by means of the stability and high purity of the polyfunctional selenol.

The invention relates to the technical field of food nutrition fortifiers, in particular to L-selenium-methyl selenocysteine and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out group protection on L-serine, then activating hydroxyl of the serine in three modes of iodination, bromination and toluenesulfonate, and respectively carrying out a methylselenylation substitution reaction on the obtained three activated intermediates and a sodium methyl selenol solution prepared in situ, and finally, completing protective group removal and solvent recovery in a rotary evaporation bottle of a rotary evaporator in one pot to obtain the L-selenium-methyl selenocysteine. According to the method, raw materials are economical and easy to obtain, reaction steps are simple, reaction conditions are mild, the product does not need optical resolution, the reaction direct yield is high, the process coupling degree is high, the provided optimal intermediate scheme is high in universality and compatibility, and convenience is provided for industrial production.

The invention discloses stable selenol and poly (selenourethane) thereof, preparation and recovery methods and application, selenol is stable micromolecules with at least two degrees of functionality, and poly (selenourethane) is prepared by directly participating in polymerization of selenol. The selenol overcomes the limitation that selenium-containing small molecules are unstable in the environment, and the polyselenourethane has rich and adjustable performance, is stable in structure, simple in preparation method, high in reaction speed, few in side reaction in the polymerization process, high in molecular weight, suitable in polydispersity coefficient and excellent in optical performance, and can be applied to the field of electronic devices. Good mechanical properties are achieved in room-temperature and low-temperature environments; meanwhile, the polyselenourethane has good thermal responsiveness and oxygen responsiveness, chemical recovery of selenol can be achieved under the simple heating condition, the polyselenourethane can be degraded by reacting with oxygen, active oxygen and the like in the service environment, meanwhile, selenium-containing components capable of being biologically utilized are released, and the selenium-containing components can be recycled. And a new opportunity is provided for development of organic selenium chemistry and selenium-containing polymers and internal and external application of organisms.

The invention relates to a preparation method and application of diselenide cross-linked mupirocin polyethylene glycol hydrogel, and belongs to the field of medical wound dressings for wound infection and promotion of wound healing. The preparation method comprises the following steps: reacting mupirocin with thionyl chloride to prepare acyl chloride, reacting with polyethylene glycol to prepare mupirocin grafted polyethylene glycol, reacting with gamma-selenobutyl ester under the action of 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene to prepare selenol, and oxidizing selenol by air to form diselenide crosslinking, thereby obtaining the diselenide crosslinked mupirocin polyethylene glycol hydrogel. The hydrogel disclosed by the invention has dual antibacterial properties of mupirocin and diselenide, can well absorb tissue waste liquid at a wound, keeps the periphery of the wound moist and free of hydrops, and promotes healing of the wound. The hydrogel does not adhere to new tissues and can be completely removed from a wound by wiping with medical 3% hydrogen peroxide, and secondary damage to the wound during stripping of a common medical wound dressing is effectively avoided.

The present invention relates to methods of producing a conformationally constrained peptide in cellulo using a pnictogen-containing crosslinker. The present invention also relates to conformationally constrained peptides obtainable by said methods and a method for screening peptide libraries for transcription factor agonists that tests whether said conformationally constrained peptide inhibits association between two candidate binding partners. The present invention also relates to the use of a pnictogen-containing cross-linker in a method of producing a conformationally constrained peptide in cellulo. The present invention also relates to recombinant peptides comprising three thiol- / selenol-containing residues linked to a pnictogen-containing cross-linker. The present invention also relates to a kit for use in said methods.

The application discloses a kind of selenium-containing unsaturated polyester amide and preparation method thereof, comprising the following steps: diamine compound, propargyl ester and selenium lactone are dissolved in organic solvent, chemical reaction is carried out, and the selenium-containing unsaturated polyester amide is obtained.The application uses diamine compound, propargyl ester and selenium lactone as raw material, generates selenium-containing unsaturated polyester amide by the click polymerization reaction of selenol and alkyne, develops a new type of selenium-containing unsaturated polyester amide preparation method, and the polyester amide obtained by preparation has narrow molecular weight distribution, controllable structure, adjustable degradation rate, good long-term stability, multiple responsiveness, good optical performance;Raw material source is extensive, avoids the cumbersome substrate synthesis, step is simple, reaction condition is mild, polymerization speed is fast, can realize efficient mass production;No catalyst is needed, no by-product is generated, and no additional purification is needed.

The invention discloses a double-layer cigarette case and a manufacturing process thereof in the technical field of tobacco packaging, the cigarette case is composed of an upper-layer cigarette case and a lower-layer cigarette case, the upper-layer cigarette case comprises an upper-layer panel and an upper-layer inner case, and the lower-layer cigarette case comprises a lower-layer panel and a lower-layer inner case; the panel and the inner box take biodegradable polyester as a matrix, and a chiral selenol compound with an anti-oxidation effect is added; the outer surfaces of the upper-layer cigarette case and the lower-layer cigarette case are coated with functional coatings containing cobalt-based zeolite imidazole frames, and the functional coatings are used for adjusting humidity and adsorbing peculiar smell. According to the upper-layer cigarette case and the lower-layer cigarette case provided by the invention, the fresh-keeping effect and the storage stability of tobacco products are remarkably improved, and meanwhile, environmental protection and anti-counterfeiting functions are achieved.

The invention discloses a preparation method of an organic polymer photo-thermal material and application of the organic polymer photo-thermal material in a laser engraving photo-thermal evaporator, and relates to the technical field of organic photo-thermal materials. The method comprises the following steps: 2, 5-bis (trimethyltin) selenol and a bis-brominated selenadiazolobenzothiadiazole derivative unit monomer are subjected to a Stille polymerization reaction to obtain a polymer material PSSe-Se, and the polymer is relatively wide in absorption spectrum and high in photothermal conversion efficiency; the 3D arch-bridge-shaped hydrogel (PVA / PSSe-Se) evaporator prepared through laser treatment has very high photo-thermal conversion capacity, shows efficient water purification capacity and has wide application prospects in the organic photo-thermal fields such as seawater purification.

The disclosure relates to the synthesis of amide containing compounds in flow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation in flow. The disclosure also relates to selective desulfurization or deselenization of amide containing compounds comprising a thiol, disulfide, selenol or diselenide functional group respectively, particularly polypeptides.

The invention discloses a polypeptide self-assembled nickel-selenium artificial hydrogenase as well as a preparation method and application thereof. The artificial hydrogenase is a polypeptide-nickel compound with a binuclear coordination center, wherein the polypeptide-nickel compound is formed by a self-assembly reaction of polypeptide and nickel ions in a buffer solution; a main chain of the polypeptide provides two strongly coordinated main chain amide groups, polypeptide cysteine and selenocysteine residues provide two side chain mercaptan and / or selenol, and the two side chain mercaptan and / or selenol are coordinated with Ni < 2 + > together to form a binuclear coordination center. The stability of the artificial hydrogenase metal coordination structure is improved, a binuclear metal center can be stably constructed, disordered polypeptide aggregation is reduced, the structural repeatability is improved, the electron transfer path of the metal center is more controllable, and an active structure can be kept under conventional solution and air conditions. An artificial biomimetic catalytic system with a clear structure, good repeatability and higher applicability can be obtained.