585 results about "Pyrazine" patented technology

The invention discloses a method for increasing the content of pyrazines and 2, 3-butanediol substances through high-temperature Daqu micro-ecological regulation and control, and belongs to the technical field of microbial food processing. The invention discloses a method for improving the content of pyrazines and 2, 3-butanediol substances through micro-ecological regulation and control of high-temperature yeast for making hard liquor, and the method comprises the following steps of: combining and inoculating strains, namely bacillus subtilis CGMCC (China General Microbiological Culture Collection Center) 10830, bacillus velezensis CGMCC 7044 and bacillus licheniformis CGMCC 20675, into wheat flour according to a proportion to prepare the high-temperature yeast for making hard liquor. According to the invention, not only are the contents of pyrazine substances and 2, 3-butanediol increased, but also the abundance of beneficial microorganisms such as bacillus, thermophilic fungi and the like is remarkably improved, and a good saccharification fermentation agent is provided for brewing high-quality white spirit.

Disclosed is a pharmaceutical composition for the treatment of tumors, the pharmaceutical composition comprising (6S, 9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl) azetidin-1-yl] pyridin-2-yl} methyl)-6-(2-fluoro-4-hydroxybenzyl)-4, 7-dioxo-2-(propyl-2-en-1-yl) hexahydro-2H-pyrazino [2, 1-c] [1, 2, 3] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [ The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and administered in combination with a MEK inhibitor.

Provided are crystalline forms of N-methyl-N-((1s,3s)-3-methyl-3-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide, pharmaceutical compositions, methods of use and methods of making thereof.

The application belongs to the technical field of etching liquid, and particularly relates to an anti-crystallization copper etching liquid and a preparation method and application thereof. The copper etching liquid is obtained by mixing hydrogen peroxide, inorganic acid, organic acid, fluorine compound, hydrogen peroxide stabilizer, organic sulfonic acid sodium salt, pyrazine polycarboxylic acid, amino acid ionic liquid and water. The components in the copper etching liquid jointly act, so that the phase stability of the copper etching liquid is significantly improved, the copper etching liquid can avoid crystallization in long-time work, and is suitable for industrial application.

This disclosure provides redox cyclable molecules for energy storage. These molecules belong to either the 4H-pyran-4-ylidene family or include a six-membered aromatic ring with one nitrogen atom at position 1 (pyridinium family) or two nitrogen atoms at positions 1 and 4 (pyrazinium family) or at positions 1 and 3 (pyrimidinium family). Molecules in these families are used as analytes in redox flow batteries.

This invention relates to formula I: This relates to the compounds of JPEG2026512972000438.jpg4271, methods for their manufacture, pharmaceutical compositions containing them, and their use in the treatment of conditions related to the function of metabotropic glutamate receptor subtype 4 (mGluR4), in particular, and / or in the prevention of such conditions. A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 The terms have the meanings provided herein.

The invention discloses a chiral supramolecular fiber structure design based on glutamic acid derivative and pyrazine co-assembly, a preparation method and application in bone regeneration and vascular regeneration. The chiral supramolecular assembly disclosed by the invention is formed by co-assembling a glutamic acid derivative and pyrazine, is an all-organic three-dimensional spiral fiber material with an accurate and controllable three-dimensional topological configuration, and can realize coupling regeneration of bones and blood vessels by cooperatively regulating and controlling dual action mechanisms of osteogenic differentiation and angiogenesis; the compound can be used for efficiently treating complex bone defects and related bone diseases. In addition, raw materials and reagents are simple and easy to obtain, reaction conditions are mild, the preparation method is simple, and good application prospects are achieved.

The invention provides a high-voltage-resistant electrolyte and a supercapacitor, the electrolyte comprises a mixed electrolyte salt, a mixed organic solvent and an additive, the additive is a mixed additive of a sulfur-containing additive and a functional additive, the functional additive containing cyano and nitrogen-rich pyrazine ring is introduced into the electrolyte, the functional additive can be oxidized preferentially at a positive electrode interface, and the positive electrode interface can be oxidized preferentially at a negative electrode interface. A stable and compact positive electrode electrolyte interface film (CEI) is constructed, and continuous decomposition of the electrolyte under high voltage is inhibited; and corrosive HF acid can be removed, transition metal ions are complexed, the catalytic chain reaction is cut off, and the structure degradation and capacity fading of the positive electrode material are relieved. By adopting the high-voltage-resistant electrolyte disclosed by the invention, the cycling stability and safety of the supercapacitor under high cut-off voltage can be remarkably improved, and the key technical problems of electrolyte decomposition, performance degradation of a positive electrode material and the like when the traditional electrolyte is applied at high voltage are effectively solved.

An object of the present invention is to provide a compound useful as an anti-tumor agent or the like, as well as a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, a compound represented by General Formula (1) or a salt thereof is provided.In the formula, R1 represents a hydrogen atom or a C1-6 alkyl group; R2, R3, R4, and R5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted, a C1-6 alkoxy group which may be substituted, or the like; R6's are the same as or different from each other and each represent a halogen atom, a C1-6 alkyl group which may be substituted, or a C1-6 alkoxy group which may be substituted; R7 represents a C3-8 cycloalkyl group which may be substituted, or the like; m represents an integer of 0 to 6; and a broken line represents a single bond or a double bond.

The invention belongs to the technical field of fermentation engineering, and particularly relates to a staphylococcus pseudoxylosus strain and application of the staphylococcus pseudoxylosus strain in enhancing the flavor of fermented food, and the preservation number of the staphylococcus pseudoxylosus strain is GDMCC NO: 66815. The strain can produce lipase and protease, and can significantly enhance the content of flavor substances such as ketones, alcohols, esters, pyrazine furans and the like in fermented food. And inoculating the staphylococcus pseudoxylosus E2 into food to be fermented, and fermenting at 25-40 DEG C for 5-35 days. Compared with natural fermentation, the content of flavor substances in fermented food can be remarkably increased, and the method is suitable for commercialization.

The invention discloses a composition for enhancing Chinese chestnut fragrance of a tea beverage as well as a preparation method and application of the composition, and belongs to the technical field of food additives. The composition is prepared from the following raw materials in parts by weight: 0.1 to 0.9 part of furanone, 0.01 to 0.2 part of linalool, 0.001 to 0.5 part of 2, 5-dimethylpyrazine, 0.02 to 0.1 part of geraniol, 0.03 to 0.05 part of beta-ionone and 0.01 to 0.25 part of geranyl acetone. According to the invention, through a unique ratio design, the scorched nut smell of pyrazine compounds, the rich caramel sweet taste of furanone, the stir-fried smoke and fire smell of 2-acetylthiazole and the freshness of geraniol and other terpene alcohols are ingeniously fused, and the complex level of Chinese chestnut fragrance is accurately reproduced. According to the present invention, the edible-grade propylene glycol is adopted as the solvent, such that the solubility, the dispersibility and the stability of the aroma composition in the tea beverage can be effectively improved, the persistence and the uniformity of the aroma release can be significantly improved, the shelf life of the tea beverage product can be easily prolonged, and the market competitiveness of the product can be enhanced.

The invention discloses a preparation method and application of a heterojunction catalyst based on a two-dimensional zinc porphyrin metal organic framework, and belongs to the field of photochemical energy conversion and photocatalytic degradation. The invention aims to solve the technical problems of high-quality preparation of the artificial photosynthetic photocatalytic composite material and how to effectively improve the photochemical energy conversion efficiency. The method comprises the following steps: 1, dissolving bismuth nitrate pentahydrate, sodium tungstate dihydrate and sodium dodecyl dimethyl benzene sulfonate in deionized water, fully stirring, and transferring the solution to a reaction kettle for hydrothermal reaction; cooling to room temperature, washing and drying to obtain bismuth tungstate solid powder; 2, adding bismuth tungstate and meso-tetra (4-carboxyl phenyl) porphin into a mixed solution of N, N-dimethylformamide and ethanol, carrying out ultrasonic treatment, and fully stirring to obtain a solution A; dissolving zinc nitrate hexahydrate, pyrazine and polyvinylpyrrolidone in a mixed solution of N, N-dimethylformamide and ethanol, and fully stirring to obtain a solution B; after the solution is fully dissolved, dropwise adding the solution B into the solution A under ultrasonic and stirring conditions, and then putting the beaker into an oil bath pan for heating; and cooling to room temperature, washing, and storing in an ethanol solution to obtain the Zn-MOF / Bi2WO6 heterojunction composite material.

The invention relates to the technical field of DNA intercalating agents, in particular to a near-infrared luminous ruthenium (II) complex, a preparation method thereof and application of the complex as a DNA intercalating agent. The preparation method comprises the following steps: firstly, preparing a precursor 4 '-(1H-benzimidazole-2-yl)-2, 2': 6 ', 2' '-terpyridyl; then, preparing a target precursor, namely, 2-(4-(anthracene-10-yl)-6-(pyrazine-2-yl) pyridine-2-yl) pyrazine as a ligand; and finally, synthesizing a complex [Ru (An-di (2-Pz) Py) (Bitpy)]. The complex is inserted into a DNA base pair as an intercalating agent, has very strong interaction with DNA, and provides basic research for researching the interaction mode of the ruthenium (II) polypyridine complex of the tridentate ligand and DNA and taking the ruthenium (II) polypyridine complex as a diagnosis and treatment reagent.

The application belongs to the technical field of medicine synthesis, and particularly relates to a steroid and 3,4 dihydropyrrole pyrazinone derivative and a synthesis method and application thereof. The derivative has a chemical structure as described in formula (I) or formula (II). The application first proposes a series of novel steroid and 3,4 dihydropyrrole pyrazinone derivatives. In addition, the application also proposes a synthesis method of the steroid and 3,4 dihydropyrrole pyrazinone derivative. The steroid and 3,4 dihydropyrrole pyrazinone derivative is obtained through a series of reactions based on dehydroepiandrosterone. The product prepared by the synthesis method has high yield and is easy to separate, and is the optimal method for preparing the steroid and 3,4 dihydropyrrole pyrazinone derivative. The steroid and 3,4 dihydropyrrole pyrazinone derivative provided by the application is confirmed by biological determination to have good toxic killing activity on aphids, spider mites and oriental armyworm insects, and can be applied to plant pest control.

To provide crystalline forms of a C-C chemokine receptor type 4 antagonist.SOLUTION: There is provided the compound 2 - ((R) - 3 - (1 - (1 - ((R) - 1 - (2, 4-dichlorophenyl) ethyl) - 3 - (trifluoromethyl) - 1H - pyrazolor3, 4-b] pyrazin-6-yl) azetidin-3-yl) piperidin-1-yl) ethan-1-ol benzenesulfonate in crystalline form.SELECTED DRAWING: Figure 1

The invention provides a 2, 5-dimethylpyrazine production strain and a construction method and application thereof.According to the strain, key feedback inhibition is relieved through a perfect metabolic engineering strategy and strategies of knocking out a competitive pathway, introducing heterologous aminoacetone oxidase, deleting L-threonine efflux protein and the like, competitive enzyme conversion of aminoacetone is reduced through a system, and the 2, 5-dimethylpyrazine production strain is obtained. Spontaneous transformation of aminoacetone in Escherichia coli is enhanced, metabolism of L-threonine is expanded to synthesis of 2, 5-dimethylpyrazine, the yield of 2, 5-dimethylpyrazine is further increased, the constructed strain does not contain plasmids and has the advantages of clear genetic background, sustainable transformation and the like, and the 2, 5-dimethylpyrazine is produced through fermentation. The method is simple to operate, can be used for directly synthesizing 2, 5-dimethylpyrazine from the beginning by using a cheap carbon source, and has a very good application prospect.

The present invention provides a compound represented by the following Formula (I):wherein ring A is a C5-C7 non-aromatic carbocycle or a 5- to 7-membered non-aromatic heterocycle; ring B is a benzene ring or the like; Q is —NHC(O)— or a 5-membered aromatic heterocycle; R1 is each independently halogen or the like; R2a and R2b are each independently hydrogen, alkyl, or haloalkyl; R3 is alkyl or the like; R4 and R5 are each independently hydrogen or the like; R6 is each independently halogen, alkyl, haloalkyl, alkyloxy, haloalkyloxy, or alkyloxyalkyl; n is an integer of 1 to 3; and m is an integer of 0 to 3.

This application relates to compounds of Formula (I):or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

The invention provides new pyrazine derivatives of formula (I): (I) or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

The present application belongs to the technical field of electronic atomization, and particularly relates to a tobacco extract composition, a preparation method and application thereof. The tobacco extract composition comprises 2,6-dimethylpyrazine, 3-acetylpyridine, dihydroactinidiolide, cembranoid diol, maackiain, furfuryl alcohol and guaiacol. The mass ratio of (2,6-dimethylpyrazine+3-acetylpyridine) to dihydroactinidiolide is greater than 0.02; the dihydroactinidiolide content is greater than or equal to 0.02 mg / g in terms of dry matter mass; and the guaiacol content is 0.004-0.025 mg / g. The overall roasting characteristics are sufficient, and the smoke-like feeling is strong. The preparation method comprises the following steps: first extracting tobacco raw materials to obtain extract A, low-temperature secondary extraction of the extract A to obtain tobacco flavor, high-temperature secondary extraction of the extract A to obtain smoke flavor, and mixing the tobacco flavor and the smoke flavor in a certain proportion to obtain the tobacco extract composition.

The invention provides an application of CC-115 in preparation of an anti-new coronavirus drug. The chemical name of the CC-115 is 1-ethyl-7-[2-methyl-6-(1H-1, 2, 4-triazole-3-yl) pyridine-3-yl]-3, 5-dihydropyrazino [2, 3-b] pyrazine-2 (1H)-ketone, and the structural formula of the CC-115 is shown in the description. An in-vitro Vero cell infection model finds that the CC-115 can inhibit the replication of a new coronavirus (SARS-CoV-2) original strain and an Omicro variant (EG.5.1), and the IC50 (half maximal inhibitory concentration) of the CC-115 aiming at the SARS-CoV-2 original strain is 0.004 [mu] M and 0.005 [mu] M. The CC-115 has the advantages that the CC-115 can inhibit the replication of the SARS-CoV-2 original strain and the Omicro variant (EG.5.1); the CC-115 can be used for research and development of anti-new coronavirus infection drugs, and has a good development prospect.

Certain substituted pyrazine-2-carboxamides of formula (I), and pharma- ceutically acceptable salts thereof, are disclosed, along with compositions containing them, and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1), and are therefore particularly useful in the treatment or prevention of cancer. [Case 1] TIFF2024527623000305.tif30161

The invention discloses a fermentation method of Maotai-flavor cigar, which is characterized in that 3-5 rounds of accumulation grains of Maotai-flavor liquor and tobacco leaves are mixed and fermented, so that the tobacco leaves directly form volatile Maotai-flavor flavor and flavor substances including Maotai flavor, caramel flavor and the like in the co-fermentation process, and meanwhile, a large amount of nitrogen-containing compounds are generated; the aroma components comprise pyrazines, pyridines and the like, so that the fermented tobacco leaves have the characteristic aroma of sauce flavor.

The invention relates to the technical field of composite fibers, in particular to a composite nanofiber with a skin-core structure and a preparation method and application of the composite nanofiber. In the composite nanofiber structure of the skin-core structure, a skin layer comprises modified boron nitride and a high-molecular polymer, and the modified boron nitride is modified boron nitride of which the surface is modified with polydopamine; and the core layer is a pyrazine compound solution. The nanofiber material prepared by the method disclosed by the invention shows excellent and stable heat conduction performance and hydrophobic performance. The material has a remarkable industrial application prospect in the fields of controlled release of tobacco essence, moisture-proof packaging and the like.

The present invention relates to a pyrazine macrolide compound and the use thereof. Specifically disclosed is a compound as represented by formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention exhibits activity against bacteria, mycoplasmas, or chlamydias, and is useful for preventing and / or treating diseases caused by bacteria, mycoplasmas, or chlamydias. Further, the compound of the present application can achieve an antibacterial activity comparable to or better than that of azithromycin or solithromycin at a lower dosage. Furthermore, the compound of the present application achieves a superior antibacterial effect on Gram-positive bacteria. Still furthermore, the compound of the present application exhibits a better inhibitory activity against mycoplasmas and a lower hepatotoxicity.

The invention discloses a synthesis method of pyrazine-2-alcohol, the synthesis route of the method is as follows: glycine is taken as an initial raw material, and a target product pyrazine-2-alcohol is obtained through esterification-ammonolysis-condensation three-step reaction process, the esterification-ammonolysis-condensation reaction process can be continuously carried out, so that the post-treatment process is greatly reduced, the yield is increased, and the production cost is reduced. Compared with non-continuous production, the method has the advantages that double periodic production times can be completed within the same time, and meanwhile, the wastewater amount and the equipment cost can be effectively reduced. The method has the advantages of low raw material cost, simplicity in operation, high product yield, environmental friendliness and the like, is suitable for large-scale production, and has a certain industrial prospect.

Treatments of neuromuscular conditions, activity-induced muscle damage, metabolic myopathies, and movement disorders with compositions comprising 2-((5-fluoropyridin-3-yl)methyl)-6-(2-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)pyridazin-3(2H)-one (Compound 1), as well as solid forms of Compound 1, and pharmaceutical compositions of Compound 1, and kits of Compound 1, are described herein.