886 results about "Pyrazine" patented technology

Provided herein are polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (Compound of Formula (I)), pharmaceutical compositions thereof, and methods of their use, for example, in the treatment of cancer. Also provided herein are synthetic processes for the manufacture of a compound of Formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline). Also provided are compounds useful in its synthesis (e.g., those of Formulae (A), (B), (By), and (H)) and synthetic processes directed thereto.

The invention relates to a conjugated microporous polymer based on a dicarbazole structure and a preparation method and application thereof, the conjugated microporous polymer has a dicarbazole structure unit and a nitrogen-containing aromatic structure unit, the dicarbazole monomer structure is represented by the formula (I): # imgabs0 #, in the structure represented by the formula (I): R = H, R1 = C = H or R1 = H, R = C = H; the structure of the nitrogen-containing aromatic monomer is shown as a formula (II): # imgabs 1 #, wherein the aromatic structure in the structure shown as the formula (II) is any one of benzene, pyridine, pyrimidine, pyrazine and pyridazine. A plurality of conjugated microporous polymers with excellent photocatalytic performance are obtained by changing aromatic monomers with different nitrogen contents, and the conjugated microporous polymers can be applied to high-efficiency production of hydrogen peroxide under photocatalytic conditions.

The invention discloses a method for increasing the content of pyrazines and 2, 3-butanediol substances through high-temperature Daqu micro-ecological regulation and control, and belongs to the technical field of microbial food processing. The invention discloses a method for improving the content of pyrazines and 2, 3-butanediol substances through micro-ecological regulation and control of high-temperature yeast for making hard liquor, and the method comprises the following steps of: combining and inoculating strains, namely bacillus subtilis CGMCC (China General Microbiological Culture Collection Center) 10830, bacillus velezensis CGMCC 7044 and bacillus licheniformis CGMCC 20675, into wheat flour according to a proportion to prepare the high-temperature yeast for making hard liquor. According to the invention, not only are the contents of pyrazine substances and 2, 3-butanediol increased, but also the abundance of beneficial microorganisms such as bacillus, thermophilic fungi and the like is remarkably improved, and a good saccharification fermentation agent is provided for brewing high-quality white spirit.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a dihydrochloride salt or a dihydrochloride, dihydrate.

The invention discloses an aggregation-induced emission metal organic framework, a preparation method thereof and application of the aggregation-induced emission metal organic framework in portable detection of low-concentration nitrobenzene. According to the aggregation-induced emission metal organic framework, ZrCl4 provides Zr < 4 + >, 2-sulfonic terephthalic acid and AIE molecule 2, 3, 5, 6-tetra (4-carboxyl phenyl) pyrazine as organic ligands, an aggregation-induced emission fluorescent material is obtained through a solvothermal method, due to the coordination effect and limited intramolecular rotation, the material shows bright blue fluorescence, and the fluorescence intensity of the aggregation-induced emission metal organic framework is greatly improved. The aggregation-state fluorescence can be obviously quenched after the fluorescent probe is contacted with nitrobenzene. The aggregation-induced emission metal organic framework material is obtained by utilizing the aggregation-induced emission performance of aggregation-induced emission molecules, and the material has good detection capability on nitrobenzene, can rapidly and efficiently detect nitrobenzene in a solution, and has good cycle performance. Meanwhile, the nitrobenzene gas can be detected for multiple times, and good sensitivity and practicability are achieved.

Disclosed is a pharmaceutical composition for the treatment of tumors, the pharmaceutical composition comprising (6S, 9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl) azetidin-1-yl] pyridin-2-yl} methyl)-6-(2-fluoro-4-hydroxybenzyl)-4, 7-dioxo-2-(propyl-2-en-1-yl) hexahydro-2H-pyrazino [2, 1-c] [1, 2, 3] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [ The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and administered in combination with a MEK inhibitor.

A pyrazine thio-biphenyl compound and its application, specifically discloses the compound of formula (II) or a pharmaceutically acceptable salt thereof.

The invention belongs to the technical field of lithium organic batteries, and provides a conjugate extended lithium-containing organic positive electrode material and a preparation method and application thereof. The synthesis process of the positive electrode material comprises the following steps: firstly, taking tetraamino p-benzoquinone as a raw material, and carrying out oximation modification reaction on the tetraamino p-benzoquinone to generate tetraamino p-oximic acid; then, carrying out composite treatment on the TAPO and a lithium source to obtain lithium tetraamino p-oximate; and finally, through a condensation polymerization reaction, further preparing to obtain the polybenzoquinone-pyrazine extended lithium oximate. Through specific chemical treatment, the organic material contains a lithium element, so that the dependence on an external lithium source (such as a metal lithium negative electrode or a lithium supplement agent) is eliminated. Through ingenious molecular design and synthesis strategies, the conductivity of the material is improved, and the rate capability, the solubility resistance, the high-temperature stability and the cycle life of the material are remarkably enhanced, so that a solid foundation is laid for long-term stable operation and high-performance expression of a battery.

The invention relates to a pyrazinyl covalent organic framework material as well as a preparation method and application thereof, 2, 5-dimethylpyrazine and aromatic aldehyde monomers are taken as construction elements, and the pyrazinyl covalent organic framework material connected with two olefins is synthesized through a Knoevenagel reaction. The pyrazinyl covalent organic framework material disclosed by the invention has good chemical stability and full-conjugate skeleton characteristics, shows excellent photocatalytic activity and cycling stability in visible light driven thioether oxidation reaction, and has potential application value in the fields of environmental restoration and green chemistry.

The invention relates to the technical field of organic chemistry, in particular to application of pyrazine compounds in the aspect of killing nematodes. The pyrazine compound has good nematicidal activity on pine wood nematodes, root-knot nematodes and aphelenchoides besseyi, and part of the pyrazine compound also has good activity on root knot nematode diseases caused by the root-knot nematodes, so that the pyrazine compound has good application prospects in the aspect of root knot nematode disease resistance.

Provided are crystalline forms of N-methyl-N-((1s,3s)-3-methyl-3-((6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide, pharmaceutical compositions, methods of use and methods of making thereof.

The present invention relates to a pyrazine derivative, an application thereof in inhibiting SHP2, and a compound of formula (I) or pharmaceutically acceptable salts, esters, isomers, solvates, prodrugs or isotope labels thereof. The structure of the compound of formula (I) is as follows. The novel pyrazine derivative provided by the present invention has excellent inhibition of SHP2 activity and can be used to prevent and / or treat non-receptor protein tyrosine phosphatase-mediated or dependent diseases or disorders.

The application belongs to the technical field of etching liquid, and particularly relates to an anti-crystallization copper etching liquid and a preparation method and application thereof. The copper etching liquid is obtained by mixing hydrogen peroxide, inorganic acid, organic acid, fluorine compound, hydrogen peroxide stabilizer, organic sulfonic acid sodium salt, pyrazine polycarboxylic acid, amino acid ionic liquid and water. The components in the copper etching liquid jointly act, so that the phase stability of the copper etching liquid is significantly improved, the copper etching liquid can avoid crystallization in long-time work, and is suitable for industrial application.

The present disclosure relates to solid-state forms and corresponding pharmaceutical compositions of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, and methods of treatment, including treatment of rheumatoid arthritis and juvenile idiopathic arthritis using the same. The treatment methods generally comprise administering to a patient (e.g., a pediatric patient) a therapeutically effective amount of upadacitinib as a stable liquid pharmaceutical composition or a solid dosage form, at a dose based on patient body weight.

This disclosure provides redox cyclable molecules for energy storage. These molecules belong to either the 4H-pyran-4-ylidene family or include a six-membered aromatic ring with one nitrogen atom at position 1 (pyridinium family) or two nitrogen atoms at positions 1 and 4 (pyrazinium family) or at positions 1 and 3 (pyrimidinium family). Molecules in these families are used as analytes in redox flow batteries.

The invention discloses a high-strength anti-crack concrete material and a preparation method thereof, and relates to the technical field of concrete. The prepared high-strength anti-crack concrete material is prepared from Portland cement, river sand, modified basalt fibers, modified polyacrylonitrile fibers, a defoaming agent, a water reducing agent and fly ash. The modified basalt fiber is obtained by reacting pretreated basalt fiber with 4-amino-2-tert-butylphenol and then reacting with 2-pyrazinyl ethanethiol, and the modified basalt fiber is obtained; the modified polyacrylonitrile fiber is obtained by reacting hydrolyzed polyacrylonitrile fiber with thiosemicarbazide, then reacting with 2, 4-difluorobromoacetophenone, then reacting with phosphorus oxychloride and N 'N-dimethylformamide, and then cross-linking with 5, 5'-diamino-2, 2 '-dipyridyl, and the modified polyacrylonitrile fiber is obtained by the following steps: reacting hydrolyzed polyacrylonitrile fiber with thiosemicarbazide, reacting with 2, 4-difluorobromoacetophenone, reacting with phosphorus oxychloride and N' N-dimethylformamide, and cross-linking with 5, 5 '-diamino-2, 2'-dipyridyl. The prepared high-strength anti-cracking concrete material has high strength, anti-aging performance and antibacterial performance.

This invention relates to formula I: This relates to the compounds of JPEG2026512972000438.jpg4271, methods for their manufacture, pharmaceutical compositions containing them, and their use in the treatment of conditions related to the function of metabotropic glutamate receptor subtype 4 (mGluR4), in particular, and / or in the prevention of such conditions. A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 The terms have the meanings provided herein.

The invention discloses a chiral supramolecular fiber structure design based on glutamic acid derivative and pyrazine co-assembly, a preparation method and application in bone regeneration and vascular regeneration. The chiral supramolecular assembly disclosed by the invention is formed by co-assembling a glutamic acid derivative and pyrazine, is an all-organic three-dimensional spiral fiber material with an accurate and controllable three-dimensional topological configuration, and can realize coupling regeneration of bones and blood vessels by cooperatively regulating and controlling dual action mechanisms of osteogenic differentiation and angiogenesis; the compound can be used for efficiently treating complex bone defects and related bone diseases. In addition, raw materials and reagents are simple and easy to obtain, reaction conditions are mild, the preparation method is simple, and good application prospects are achieved.

The invention discloses a waterproof high-temperature-resistant low-temperature-resistant UV (ultraviolet) photocuring adhesive and a preparation method thereof, and relates to the field of photocuring adhesives. When the waterproof, high-temperature-resistant and low-temperature-resistant UV photocuring adhesive is prepared, clay, maleic anhydride and 2, 6-diaminopyrazine are uniformly mixed to prepare modified clay; the preparation method comprises the following steps: reacting epoxy resin with phosphoric acid di (hydroxyethyl acrylate) ester to obtain modified resin; octamethylcyclotetrasiloxane, mercaptopropyl methyl dimethoxy silane, trifluoropropyl methyl dimethoxy silane and hexamethyldisiloxane are subjected to a reaction, and modified organic silicon is obtained; and uniformly mixing the modified resin, the modified clay, methylboronic acid and the modified organic silicon to obtain the waterproof high-temperature-resistant low-temperature-resistant UV photocuring adhesive. The waterproof, high-temperature-resistant and low-temperature-resistant UV photocuring adhesive prepared by the invention has excellent flame retardance, waterproofness, high-temperature resistance and low-temperature resistance.

The invention provides a high-voltage-resistant electrolyte and a supercapacitor, the electrolyte comprises a mixed electrolyte salt, a mixed organic solvent and an additive, the additive is a mixed additive of a sulfur-containing additive and a functional additive, the functional additive containing cyano and nitrogen-rich pyrazine ring is introduced into the electrolyte, the functional additive can be oxidized preferentially at a positive electrode interface, and the positive electrode interface can be oxidized preferentially at a negative electrode interface. A stable and compact positive electrode electrolyte interface film (CEI) is constructed, and continuous decomposition of the electrolyte under high voltage is inhibited; and corrosive HF acid can be removed, transition metal ions are complexed, the catalytic chain reaction is cut off, and the structure degradation and capacity fading of the positive electrode material are relieved. By adopting the high-voltage-resistant electrolyte disclosed by the invention, the cycling stability and safety of the supercapacitor under high cut-off voltage can be remarkably improved, and the key technical problems of electrolyte decomposition, performance degradation of a positive electrode material and the like when the traditional electrolyte is applied at high voltage are effectively solved.

An object of the present invention is to provide a compound useful as an anti-tumor agent or the like, as well as a pharmaceutical composition, an anti-tumor agent, and a dihydroorotate dehydrogenase inhibitor, each of which contains the compound. According to the present invention, a compound represented by General Formula (1) or a salt thereof is provided.In the formula, R1 represents a hydrogen atom or a C1-6 alkyl group; R2, R3, R4, and R5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, a C1-6 alkyl group which may be substituted, a C1-6 alkoxy group which may be substituted, or the like; R6's are the same as or different from each other and each represent a halogen atom, a C1-6 alkyl group which may be substituted, or a C1-6 alkoxy group which may be substituted; R7 represents a C3-8 cycloalkyl group which may be substituted, or the like; m represents an integer of 0 to 6; and a broken line represents a single bond or a double bond.

The invention belongs to the technical field of fermentation engineering, and particularly relates to a staphylococcus pseudoxylosus strain and application of the staphylococcus pseudoxylosus strain in enhancing the flavor of fermented food, and the preservation number of the staphylococcus pseudoxylosus strain is GDMCC NO: 66815. The strain can produce lipase and protease, and can significantly enhance the content of flavor substances such as ketones, alcohols, esters, pyrazine furans and the like in fermented food. And inoculating the staphylococcus pseudoxylosus E2 into food to be fermented, and fermenting at 25-40 DEG C for 5-35 days. Compared with natural fermentation, the content of flavor substances in fermented food can be remarkably increased, and the method is suitable for commercialization.

The present invention relates to salts and crystalline forms of 2-(3-(8-Amino-6-(trifluoromethyl)imidazo[1,2-a]pyrazin-3-yl)-4-methylphenyl)-3,3,3-trifluoro-2-hydroxypropanamide, crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-methyl-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, and crystalline forms of 8-amino-N-(2-hydroxy-2-methylpropyl)-3-(2-(methyl-d3)-5-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide, which are PI3K inhibitors useful in the treatment of cancer and other diseases.

The invention discloses a pottery jar capable of regulating and controlling the content of flavor components of baijiu and a preparation method of the pottery jar, and belongs to the field of baijiu processing. The method for preparing the pottery jar capable of regulating and controlling the content of the flavor components of the Baijiu comprises the following steps: S1, uniformly mixing pottery clay and a catalyst, and adding mud to prepare a mud cake; s2, molding the mud cake to obtain a pottery jar green body; s3, drying the pottery jar green body; and performing high-temperature firing to obtain the pottery jar capable of regulating and controlling the content of the flavor components of the white spirit. According to the preparation method, the catalyst is added during preparation of the pottery jar, so that the content of flavor components, especially the content of pyrazine substances, furan substances and phenolic aldehyde substances, of the Baijiu can be regulated and controlled.

The present invention relates to a strain of Rhizopus delbrueckii that produces multiple pyrazines. Rhizopus delemar ) strains and screening and cultivation methods and applications thereof, the said Dale Rhizopus strain producing multiple pyrazines is named JSY-F002 strain, the deposited unit is China Center for Type Culture Collection (CCTCC), the deposited time is March 20, 2024, and the deposited number is CCTCC No.M 2024533. Through headspace solid phase microextraction combined with comprehensive two-dimensional gas chromatography-time of flight mass spectrometry (HS-SPME-GC×GC-TOFMS) detection and analysis, the strain can produce nearly 9 pyrazine substances after high temperature culture on wheat / barley / pea raw material culture medium, and is a good flavor strain, which is used in the process of liquor koji making or related fermented food brewing, solving the problem of insufficient functional flavor strain resources in the field of liquor koji making and traditional fermented food brewing.

To provide a beer-flavored fermented alcoholic beverage with a reduced sensation of prickliness in a mouth.SOLUTION: A beer-flavored fermented alcoholic beverage has a total pyrazine content of 10 ppb or less in the beverage, with a total furan content of 1100 ppb or more.SELECTED DRAWING: None