21 results about "Bone regeneration" patented technology

The invention provides an ultrasonic stimulation response hydrogel stent as well as a preparation method and application thereof. A coaxial 3D printing technology and surface chemical modification are adopted to prepare the ultrasonic stimulation response hydrogel stent with immunoregulation and osteogenesis promotion functions. The hydrogel with the skin-core structure comprises core layer hydrogel and skin layer hydrogel, wherein the core layer hydrogel is composed of methacrylated gelatin chelated metal ions modified by a diphosphonic acid compound and a methacrylate modified polymer, and the skin layer hydrogel is composed of methacrylated gelatin modified by an immunoregulatory factor and an organic sound-sensitive agent. The ultrasonic stimulation response hydrogel stent has the advantages of ultrasonic stimulation response release, good biocompatibility, macrophage M2 type polarization regulation, angiogenesis promotion, bone regeneration promotion and the like, and has potential application prospects in the field of bone defect regeneration and repair.

The present disclosure relates to a composite material for application to a bone defect site to promote new bone growth at the site comprising: a combination of freeze-dried mineralized bone allograft particles; and a monophasic gel comprising cross-linked hyaluronic acid; wherein the hyaluronic acid is cross-linked by a cross-linking agent, the cross-linking agent being a diglycidyl ether. The present disclosure also relates to a method to obtain a composite material for application to a bone defect site to promote new bone growth at the site comprising mixing freeze-dried mineralized bone allograft particles with a monophasic gel comprising hyaluronic acid; and to a bone regenerative material comprising the composite material as defined herein for use in a method of treating a patient suffering from a degenerative bone condition, bone loss, bone deficiency or bone atrophy.

The invention provides a mesenchymal stem cell medicine for promoting knee joint cartilage regeneration as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: reacting polyethyleneimine with linoleoyl chloride to prepare linoleoyl chloride modified polyethyleneimine for preparing curcumin lipidosome, and reacting with multifunctional peptide to prepare multifunctional lipidosome; the mesenchymal stem cells are mixed with self-assembled RADA16 polypeptide embedded with TGF-beta1 and BMP-6 and subcultured mesenchymal stem cells, the mixture is added into autologous platelet-enriched plasma, and the mesenchymal stem cell medicine for promoting knee joint cartilage regeneration is prepared. According to the invention, curcumin is embedded by lipidosome, mesenchymal stem cells can promote osteogenesis differentiation by using provided nutrients, and interference of inflammatory microenvironment is effectively prevented. Meanwhile, the self-assembled RADA16 polypeptide wraps TGF-beta1 and BMP-6, the synergistic effect is beneficial to regeneration and repair of cartilage tissue, proliferation of bone cells is promoted, and cartilage repair and regeneration are facilitated.

A surgical implant aperture insert for use in a surgical implant system; and a surgical implant system for use in arthroplasty, the surgical implant system comprising an aperture and a surgical implant aperture insert. The insert increases the surface area of a surgical component that can be used for bone regrowth, and a mating component may be provided to allow for use of different fixtures within the aperture.

The invention discloses a preparation method and an application of a bone targeting catechin-strontium metal polyphenol nano particle. The system takes a metal-polyphenol network (MPN) formed by coordination self-assembly of strontium ions and catechin as a core, and tetracycline is modified on the surface of the MPN to construct a bone targeting functional layer. The MPN structure can significantly enhance the loading efficiency and physiological stability of catechin, and the tetracycline modification on the surface endows the nanoparticles with excellent bone targeting ability. When reaching an osteoporosis focus, the nanoparticles can respond to a local weakly acidic microenvironment and controllably release catechin, and exert antioxidant and anti-inflammatory effects, thereby reversing a pathological microenvironment unfavorable for bone regeneration. Meanwhile, the MPN skeleton is gradually degraded in vivo, and the released Sr < 2 + > can promote proliferation and differentiation of pre-osteogenic cells, inhibit the activity of osteoclasts and promote formation of new bones. The system integrates bone targeting, microenvironment response drug release, immunoregulation and ion regulation treatment, and provides a new strategy for precise treatment of osteoporosis.

A surgical implant opening insert for use in a surgical implant system, and a surgical implant system for use in arthroplasty, comprising an opening and the surgical implant opening insert, are provided. The insert can increase the surface area of ​​the surgical component available for bone regrowth and provide fitting means to allow the use of different fixation devices within the opening.

The invention belongs to the technical field of biological polypeptide preparation, and particularly relates to a tilapia scale collagen peptide as well as a preparation method and application thereof. The tilapia mossambica scale collagen peptide is composed of the following peptide fragments: PDPFRMY, GPQGPIGPR, PFRMY, GPSGPP, APDPFR, KAPDPFRMY, PGPGPMGL, DPGPGPMG, DPFRMY, PGGLP, PGPGMP, GPFS, FGAG, PLGP, GPLG, PGR, GPAGGL and PGGGF. The tilapia mossambica scale collagen peptide prepared by the invention has no toxicity, can improve the phagocytic ability of RAW264.7 cells and promote the cells to secrete NO, and can effectively enhance the immunocompetence; the screened tilapia mossambica scale collagen peptide is easier to digest and absorb and higher in bioavailability; the composition can participate in development and migration of cells and tissues and formation of extracellular matrixes, and promotes regeneration of bones, skin and cartilages.

A bone-regeneration material comprising a biodegradable fiber produced using an electrospinning process, wherein the biodegradable fiber comprises 30 to 50 wt % of PLLGA resin and 70 to 50 wt % of β-TCP fine particles substantially uniformly dispersed in the PLLGA resin without forming aggregates, wherein the β-TCP fine particles are not chemically bonded to the PLLGA resin, and surroundings of the β-TCP fine particles are covered by the PLLGA resin so that the β-TCP fine particles are not separated from the biodegradable fiber during a formation of the fiber, and wherein the bone-regeneration material is sterilized by using radiation sterilization with gamma ray.

The invention relates to the field of biomedical materials, and discloses a preparation method of a calcium-phosphorus-based biological ceramic artificial bone, which comprises the following steps: firstly, constructing a Ca-P core-shell precursor containing a Zn < + > enriched core and a Sr < + > enriched shell, and carrying out directional diffusion induction treatment through short-time microwave pulse or thermal pulse to activate core-shell interface ion migration without causing complete crystallization; the beta-TCP powder obtained through freeze drying and segmented calcination is uniform in doped element distribution. And then composite printing slurry containing PVA and MC and added with sodium alginate and nano-clay is adopted, so that the slurry is quickly crosslinked and cured under ultraviolet light, and the extrusion stability and interlayer bonding strength are remarkably improved. And finally, carrying out microwave-assisted sintering to obtain the ceramic scaffold with high density, high mechanical property and good biological activity. According to the method, uniform synergistic doping of Zn < + > / Sr < + > is achieved, the mechanical strength, printing precision and osteogenesis promotion and antibacterial performance of the stent are improved, and the method is suitable for preparing the high-performance bone regeneration stent.

According to the nano bionic bone tissue engineering hydrogel and the preparation process and application thereof, through the anti-oxidation and anti-inflammatory dual-function characteristics of tannic acid (TA), the osteogenesis promoting synergistic effect of TA and CaP / Mg < 2 + > and form-mechanical regulation and control of Gel-MA hydrogel (methylacryloylated gelatin hydrogel), the nano bionic bone tissue engineering hydrogel is prepared; the technical bottlenecks of insufficient inflammation microenvironment regulation, low bone regeneration induction efficiency and incomplete defect repair in the prior art are systematically solved, and an innovative solution with functional suitability and biocompatibility is provided for periodontitis alveolar bone absorption treatment. The nano bionic bone tissue engineering hydrogel can be directly used or used for loading medicines, the nano bionic bone tissue engineering hydrogel is filled into a bone defect area before photocuring (in a liquid state), and then the filled material is subjected to photocuring crosslinking to form a three-dimensional network gel structure which is accurately matched with the shape of the bone defect area.

This invention discloses a polyetheretherketone (PEEK) implant with time-dependent regulation of bone defect repair, its preparation method, and its applications, relating to the field of biomedical materials technology. The PEEK implant comprises: a substrate with a micro / nano topological structure on its surface, and a ROS-responsive multifunctional peptide chain loaded on the micro / nano topological structure; the substrate is made of PEEK or a PEEK composite material; the ROS-responsive multifunctional peptide chain comprises: a first functional short peptide with anti-inflammatory activity, a second functional short peptide with pro-angiogenic and / or bone differentiation-promoting effects, and a ROS-responsive molecule connecting the first and second functional short peptides; the second functional short peptide is connected to the micro / nano topological structure. This invention achieves multi-stage synergistic regulation of the entire bone regeneration process, significantly improving its in vivo bone integration efficiency and bone defect repair effect while maintaining the excellent mechanical properties of PEEK.

A surgical implant aperture insert (20) for use in a surgical implant system; and a surgical implant system for use in arthroplasty, the surgical implant system comprising an orifice (8) and a surgical implant orifice insert. The insert increases the surface area of a surgical component that can be used for bone regrowth, and a mating component may be provided to allow for use of different fixtures within the aperture.

Provided is a bone regenerative agent which can repair a bone defect site with preventing from remaining at the bone defect site. The bone regenerative agent comprises zinc subcarbonate containing hydrozincite. It is preferred that the zinc subcarbonate has a Zn2+ ion elution amount of 0.1 ppm by mass or more after an elution test and also has a pH value of 7.2 or more and less than 8.3 after an elution test. It is preferred that some carbonate ions in the hydrozincite are substituted by sulfate ions or chloride ions. It is preferred that the bone regenerative agent is applied to a bone defect site.

The purpose of the present invention is to provide a cartilage regeneration promoter. The cartilage regeneration promoter includes (A) hydroxycitric acid and / or a salt thereof, and (B) a sugar selected from the group consisting of chondroitin sulfate and a salt thereof, hyaluronic acid and a salt thereof, a proteoglycan, and the constituent sugar of the above sugars, and is capable of promoting cartilage regeneration.

The present invention relates to a method for preparing a tissue repair material, comprising the steps of pretreatment, defatting, virus inactivation, decellularization, material recovery, freeze-drying, and sterilization. It also relates to a tissue repair material prepared by this method and its application. The method for preparing a tissue repair material provided by the present invention can effectively remove immunogenic substances from the material while better restoring the tensile strength and elasticity of the tissue material, thereby obtaining a bioscaffold material with improved biocompatibility, non-immunogenic cell attachment, proliferation, differentiation, and mechanical properties. The tissue repair material obtained by the method of the present invention has excellent efficacy in guiding cartilage regeneration.

A surgical implant opening insert (20) for use in a surgical implant system is provided, as well as a surgical implant system for use in arthroplasty, comprising an opening (8) and the surgical implant opening insert. The insert can increase the surface area of ​​surgical components available for bone regrowth and provide fitting means to allow the use of different fixation devices within the opening.

The invention discloses a preparation method of a gradient-structure osteochondral regeneration scaffold based on multi-material photocuring printing, and relates to the technical field of biomedical engineering.The preparation method comprises the following steps that different kinds of materials, cells and growth factors needed by the osteochondral regeneration scaffold are prepared into corresponding ink; the multi-material photocuring printing equipment is used for conducting integrated printing on the ink used by all the layers of osteochondral regeneration scaffolds, the osteochondral regeneration scaffold of a step-shaped or conical structure is obtained, and the osteochondral regeneration scaffold comprises at least one cartilage layer, a transition layer and a bone layer. According to the preparation method of the gradient-structure osteochondral regeneration scaffold based on multi-material photocuring printing, materials, cells and factors required by a cartilage layer, a transition layer and a bone layer are respectively loaded in different photocuring material troughs through a multi-material photocuring printer, so that integrated printing of the gradient-structure osteochondral regeneration scaffold is realized; and a technical platform is provided for manufacturing of a tissue engineering gradient structure.

The invention discloses application of guar gum and xylooligosaccharide in promoting growth of cornu cervi pantotrichum of sika deer, and belongs to the technical field of animal breeding. The invention reveals that guar gum and xylooligosaccharide synergistically promote the growth of pilose antler through'microorganism-metabolism-pilose antler growth axis' for the first time, and researches find that guar gum and xylooligosaccharide not only enhance the ability of rumen microorganisms to degrade plant polysaccharides, but also promote the utilization of host-derived polysaccharides, can promote the growth of pilose antler, and can promote the growth of pilose antler. The obvious promoting effect is achieved on the pilose antler proliferation and mineralization process. The guar gum and / or xylooligosaccharide are / is added into the sika deer total mixed ration with the concentrate-to-coarse ratio of 55: 45 to feed sika deer, so that the weight of pilose antler is remarkably increased. The invention provides an effective scheme for increasing the yield of the cornu cervi pantotrichum of the sika deer, and particularly has important transformation potential in the aspects of osteoporosis prevention and treatment, bone regeneration medicine and functional feed development.

The present invention discloses a method for preparing a gradient-structured osteochondrocyte regeneration scaffold based on multi-material photocuring printing, which relates to the field of biomedical engineering technology. The preparation method is as follows: different types of materials, cells, and growth factors required for the osteochondrocyte regeneration scaffold are formulated into corresponding inks; the inks used for each layer of the osteochondrocyte regeneration scaffold are integratedly printed using a multi-material photocuring printing device to obtain an osteochondrocyte regeneration scaffold with a stepped or conical structure, wherein the osteochondrocyte regeneration scaffold includes at least one cartilage layer, a transition layer, and a bone layer. This method for preparing a gradient-structured osteochondrocyte regeneration scaffold based on multi-material photocuring printing uses a multi-material photocuring printer to load the materials, cells, and factors required for the cartilage layer, transition layer, and bone layer into different photocuring material troughs, thereby achieving integrated printing of the gradient-structured osteochondrocyte scaffold and providing a technical platform for the manufacture of gradient structures in tissue engineering.

Examples of modular intermedullary nails are described. In one case, a modular intermedullary nail includes a proximal end component, a distal end component and a modular component. The modular component includes a piezoelectric segment to generate an electric charge based on mechanical stress applied to the modular intermedullary nail. A proximal connector connects the modular component to the proximal end component, and a distal connector connects the modular component to the distal end component. The intermedullary nail further includes at least one electrode to electrically couple the electric charge to facilitate bone regrowth.

The invention discloses a preparation method of a photo-crosslinking injectable hydrogel for promoting bone repair, by optimizing the composition of a photo-crosslinking system and a preparation process, the prepared hydrogel has injectability, gradient adaptive adhesion strength and excellent adhesion stability, and can be precisely regulated and cured through light control to avoid secondary operation stripping injury. The hydrogel is stable in structural performance and not prone to excessive swelling in a simulated bone physiological environment, the mechanical properties of the hydrogel can be matched with cortical bones and cancellous bones respectively, and the hydrogel has remarkable bone regeneration promoting activity and can provide a proper microenvironment for bone tissue regeneration. When cancellous bone is repaired, the hydrogel has excellent toughness and elastic recovery rate, can bear dynamic load and avoids stress shielding effect; due to the injectable characteristic, irregular bone defect parts can be accurately filled with the material, and the adaptability of the material and a defect area is improved. The hydrogel prepared by the method can provide a better and safer material for a bone repair operation, efficiently assists bone tissue regeneration, improves the operation effect and solves the limitation of the existing material.