77 results about "Bone regeneration" patented technology

A collagen matrix material is charged with a cell growth-promoting derived nucleic acid sequence. The nucleic acid sequence-charged collagen matrix material may be utilized in a method of promoting regeneration of surface cartilage of a joint. In the method, an area of injury is covered with the nucleic acid sequence-charged collagen matrix material, the collagen matrix material is fixed over the area to be treated, and the area is allowed to heal.

This invention is related to bone fillers, hard tissue supporting films and three dimensional scaffolds that contains composite particle of inorganic compound / water soluble polymer (such as β-TCP / Gelatin), that can lead to bone regeneration and release an antibacterial or bioactive agent at the defect area. The bone regenerative hard tissue supporting films and scaffolds were obtained by addition of antibacterial or bioactive agent loaded composite particles into biodegrable polymer (such as PCL) matrix.

Scaffolds made of composite materials and uses thereof in the field of biomedical engineering are disclosed, wherein the composite materials comprise bioactive microparticles that could induce the human bone tissue to regenerate. The scaffolds uses the combination of silicon, calcium, and phosphorus microparticles as bioactive substance that could actively induce the human osteoblasts to proliferate and differentiate, promote the formation and calcification of new bone. Furthermore, the scaffolds employs organic polymer as carrier, takes a three-dimensional structure and external anatomical shape, and exhibits several characteristics compatible with the regeneration of bones and the neogenesis of blood vessels, thereby it could be used safely, economically and effectively for repairing the defect of bone tissue as well as in orthopedic operation of human bone. The present invention also discloses the methods for preparing the scaffolds.

Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.

The invention relates to an injectable composite material for bone repair. According to the composite material, biological tissue materials and biological ceramics are organically combined so as to form an injectable medical material with a three-dimensional scaffold function. In the invention, a biological tissue material substrate is micro-fiber with a natural crosslinking structure, is free of additional physical or chemical crosslinking, has good biocompatibility, and can be slowly degraded completely in vivo; and the biological tissue materials and the biological ceramics can be combined in multiple ways. In the composite material, after the biological ceramics serving as a reinforced phase are combined with the biological tissue materials, a favorable template can be provided for bone tissue regeneration in vivo, and bone growth can be effectively induced. The injectable material provided by the invention can be used for seamlessly filling bone defect of any size, and biological agents including bone marrow are added in the process, so that the bioactivity is further enhanced. Therefore, the material can be widely used for bone defect caused by wounds, resection of tumors, osteonecrosis, infection and the like.

Aporous composite fibrous scaffold for repair or regeneration of bone is disclosed. The scaffold comprises a first biopolymer forming a porous matrix and a second biopolymer forming fiber reinforcement. The biocompatible scaffold is configured to maintain balance between porosity and mechanical strength which could aid cellular infiltration and bone tissue regeneration. A method of preparing the porous composite scaffold is also disclosed.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillo facial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and / or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and / or bioactive silica glasses and gels.

Present invention depicts a poly-porous (micropore) hollow screws as diffusion chamber filled with core matrix for targeted delivery of growth factors and bone marrow stem cells. The screws comprise at least two parts: the distal part of the screw consists of the tip of the screw made of poly porous material and hollow inside proximally. It has threaded navel attached to the threaded nipple of the distal part of the proximal screw which has the screw head and is made of the solid material of the same kind. The screw head had hexagonal recess targeted for screw driver insertion. Assembly of screw created a chamber in the middle of the screw. The chamber is filled with core matrix consisting of gelatin nano-particles pre-impregnated with BMPs (BMP2 / BMP7 for bone or BMP12 for tendon, ligament) and fibrin sealants or Chitosan dispersed with bone marrow stem cells and / or other growth factors. Bioactive protein core material is prepared during the surgery and filled the chamber of the screw by the surgeon. Fibrin sealants or Chitosan will polymerize to form a gel to hold the growth factors and stem cell in place. The screw can be used as the lag screw or other function to provide mechanical fixation in variety of condition. Once the screw implanted in the human body, the fibrin sealant or Chitosin / gelatin nano-particles are gradually degraded and slowly release growth factors and stem cells via micropores of screw to facilitate the bone healing and regeneration. The gelatin nanoparticles and fibril sealant / or Chitosan matrix also serve as the scaffold and platform for bone in-growth to the screw or alternatively, the stem cell inside of screw can regenerate new bone, providing the biological fixation. At the mean time as the bone regenerate and / or in growth, mechanical strength of the screw increased.

The invention provides a polyether-ether-ketone material and a modification method based on plasma immersion ion implantation and application. The modification method comprises the steps: depositing a diamond-like film on the surface of the polyether-ether-ketone material by the plasma immersion ion implantation technique or depositing the diamond-like film and introducing nitrogen-containing active functional groups, and thus obtaining a surface-modified polyether-ether-ketone material. The surface-modified polyether-ether-ketone material can be applied to the fields such as medical regeneration materials, functional materials, bioactive materials, etc. The modification method does not reduce the excellent mechanical property of main materials while greatly improving the biological activity of the surface of the polyether-ether-ketone material, therefore, the polyether-ether-ketone material has excellent biocompatibility and achieves the effect of repairing bone defects while promoting the regeneration function of new bones. The surface modification method based on the plasma immersion ion implantation technique has the advantages of simple process, low cost and mass production and benefits industrial production.

The invention discloses a growth factor nanotube slow-release system used for osseointegration and a preparation method and application thereof, the nanotube slow-release system includes a titanium alloy implant, a titanium dioxide nanotube coating is prepared on the titanium alloy implant surface by the method of anodic oxidation, and the titanium alloy implant is loaded with a growth factor. The growth factor nanotube slow-release system has the advantages that: (1) the growth factor nanotube slow-release system can improve the nanotube drug loading amount by a simple and effective method of vacuum aspiration; (2) the invention also provides a rhPDGF- BB nanotube slow-release system which can significantly promote the osseointegration in bone osteoporosis state, rhPDGF-BB is approved by the FDA to be used in clinical osteanagenesis therapies, and clinical application of the nanotube slow-release system may be provided; and (3) including nanotube preparation, therowth factor nanotube slow-release system is in no need of special, complex and expensive equipment, simple in operation process, and conducive to the promotion and use.

A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and / or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.

Tunnel bone grafting according to the proposed method can be used when an individual has a facial bone defect due to periodontal disease, cleft palate or trauma. The proposed method can be utilized for implant placement, it reduces wrinkles and supports facial muscle in order to make the individual look younger. The method can also be used to create a thicker alveolar ridge in order to stabilize full dentures or partial dentures. Its advantages over conventional guided bone regeneration techniques is that the proposed method is minimally invasive and lessens trauma to patients, prevents soft tissue opening, and reduces surgery time. Specifically, it minimizes the incision size and thus reduces trauma to the patient. Further, this reduces the risk of complications, including excessive bleeding, due to the minimization of the incision size. There is also considerable reduction in post surgery swelling using the proposed method as opposed to conventional techniques.

The present invention is in the field of tissue engineering and, specifically, that of osseous regeneration. The invention relates to a porous three-dimensional matrix of biocompatible monetite, of predefined structured porosity and reabsorbable, and method of synthesis capable of producing said material and applications thereof. These matrices constitute a perfect base for cell colonisation and proliferation permitting application thereof in tissue engineering and osseous regeneration by virtue of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularisation, etc.

Various porous implantable interbody or spinal fusion devices, which may be formed of metal, metal alloy or polymer are provided. These porous implantable interbody devices may be engineered to have a porous network or scaffold structure for repairing and / or replacing damaged bone segments in the spine while allowing better fusion for improved bone healing and bone regrowth.

A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and / or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.

The present invention provides a hybrid hydrogel stabilized by multivalent cross-linking domains. The hydrogel combines inorganic nanoparticles along with an organic polymer network. The resulting material has reinforced mechanical properties and significant mineralization, and affords sustained long-term release of ions. Furthermore, ions released from the hydrogel can enhance cell spreading and promote the osteogenic differentiation of implanted cells. These promising results indicates that the provided compositions and methods are particularly appealing for bone regenerative applications.

The invention discloses a slow-release antibacterial composite film capable of guiding bone tissue regeneration and a preparation method thereof. The preparation method comprises the following steps: by using a bacterial cellulose membrane as a substrate, supporting nano calcium phosphate on the bacterial cellulose membrane to obtain a nano calcium phosphate / bacterial cellulose membrane, and modifying the nano calcium phosphate / bacterial cellulose membrane by using dopamine, thereby obtaining the dopamine-modified bacterial cellulose membrane; preparing gamma-polyglutamic acid / levodopa gel microspheres, and supporting an antibacterial drug to obtain a functionalized gel; and pouring the functionalized gel onto the surface of the dopamine-modified bacterial cellulose membrane, and drying to obtain the slow-release antibacterial composite film capable of guiding bone tissue regeneration. The slow-release antibacterial composite film capable of guiding bone tissue regeneration has the firmly combined interface, has certain mechanical properties, bone guiding activity and bone conduction activity, and can slowly release the antibacterial drug to prevent or treat local infection.

The invention belongs to the technical field of glass bone restoration, and discloses a porous biological activity glass bone restoration material, a preparation method and application thereof. Aftera prepared porous biological activity glass bone restoration material being implanted into an organism, the biocompatibility is good; the prepared bone restoration material is composed of natural macromolecular materials and inorganic materials being bone-like components, the surface of the prepared bone restoration material is capable of forming a good interface relation with cells, any parts ofany bone defect can be implanted in a orthopedic surgery, application parts are not limited, good biocompatibility, no cytotoxicity and no immune rejection are achieved. According to the prepared bonerestoration material adopted by the preparation method, good degradation performance is achieved, materials are gradually degraded with growth of new bone, and thus no occupation and no interfere tobone reconstruction are achieved; and the restoration cycle is shortened.

The invention discloses a method for constructing tissue engineered cartilages in vivo, which comprises the following steps: carrying out multiplication culture on a great deal of auricular cartilage cells in vitro; preparing a stratified cartilage cell membrane; preparing a PLC (three-dimensional printing) inner core with a special form; preparing a sandwich mode of the stratified cartilage cell membrane and a material; and performing an operation for implanting a compound containing the membrane and the inner core into animal muscle. According to the method, a three-dimensional printed material is used as an inner core scaffold, and the material is coated by the cell membrane to prevent the scaffold material from being in direct contact with in vivo tissue, thereby reducing the inflammatory reaction caused by the scaffold material in vivo and increasing the success ratio of cartilage regeneration in vivo. In addition, through three-dimensional printing, inner core materials with various special forms can be manufactured, and tissue engineered cartilages corresponding to the inner core materials are constructed; and meanwhile, by adjusting the height of a printing layer, the density of grids and the mode of wiring, due to different superimposed layers of the membrane, the constructed cartilages have different mechanical strength which can reach a relatively high level.

A medical barrier made by micro porous expanded polytetrafluoroethylene (ePTFE) is disclosed. The medical barrier allows the attachment and ingrowth of cells and tissue to within one, two or several cellular length, but not across the sheet material, and the tissue can still be pulled or peeled apart from the micro porous sheet with non-surgical and non-traumatic procedures. This medical barrier of the present invention is particularly useful in guided tissue regeneration in the repair of bone defects, as for example in the repair of alveolar bone defects. The medical barrier prevents the entry of rapidly migrating gingival tissue cells into the defect and allows the alveolar bone to regenerate.

The invention discloses a bioactivity glass porous bone repair material and a preparation method thereof. The method includes: using a sol-gel method to prepare bioactivity glass powder, evenly mixingthe bioactivity glass powder, a binder and a pore-forming agent, performing compression molding, performing isostatic cool pressing, and performing thermal treatment sintering to remove the pore-forming agent so as to obtain the 58S bioactivity glass porous bone repair material. The bioactivity glass porous bone repair material and the preparation method have the advantages that the pore diameterof the prepared bone repair material is about 50-300 micrometers, the porosity of the prepared bone material can be controlled to be 40-70%, and the prepared bone repair material which has the mechanical performance similar to cancellous bones is good in pore diameter uniformity, good in surface smoothness, controllable in degradation rate and applicable to bone defect repair and bone tissue regeneration; meanwhile, the preparation method is simple in process, easy in raw material obtaining, low in cost and easy to achieve industrialization.

The invention belongs to the field of biomedical engineering, and discloses a preparation method of an osteanagenesis material. The preparation method comprises the steps of (1) enabling chitosan andpolyoxyethylene to completely dissolve in a 90v / v% acetous solution, and performing uniform stirring to obtain spinning liquid; (2) performing electrostatic spinning with the spinning liquid to obtainchitosan / polyoxyethylene nanofibers; (2) washing the chitosan / polyoxyethylene nanofibers with a DMEM culture medium to be neutral, performing drying, then performing treatment with a plasma processorand performing activating; and (4) soaking activated nanofibers in the DMEM culture medium containing bone growth factors and epigallocatechin gallate ester / carotenoid liposome, performing negative pressure flash explosion, performing a grafting reaction, performing centrifugation and performing freeze-drying. According to the osteanagenesis material prepared by the preparation method, the bone growth healing speed can be effectively increased.

Provided herein are a membrane-type artificial scaffold for guided bone regeneration (GBR) and a method for fabricating the same. The membrane-type artificial scaffold according to the present invention comprises: a first layer made of at least one fiber layer arranged in parallel with each other with a first spacing therebetween such that the fiber layer contacts a bone tissue in vivo; and a second layer stacked on the first layer and made of at least one fiber layer arranged parallel to each other with a second spacing therebetween such that the fiber layer contacts a soft tissue in vivo. The first spacing is larger than the second spacing.

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.

The present invention discloses a treatment instrument for vascular necrosis of femoral head, which at least comprises a composite membrane, a controlling system with a human-machine interface, a pressure controlling module and a storage liquid bottle. The composite membrane is used as the sealing material, which generates negative pressure. On one hand, effect of proper microenvironment for regeneration and repairing of the bone tissue provided by the composite membrane and effect of the growth factor are used. On the other hand, effect that negative pressure can promote osteocyte proliferation, improve growth of the selected cells, the growth factor and the vascular. A negative attraction is added in the composite membrane. The bone tissue regeneration can be induced by comprehensive utilization of the membrane and negative pressure. Therefore speed of bone tissue regeneration is increased. Modular design is applied in the treatment instrument. Each component is independent relatively. Three kinds of power supply modes are provided with under-voltage protection or over-voltage protection. The negative pressure pump and the pressure-reducing valve are automatically controlled by a pressure sensor monitoring with high accuracy and the micro controlling device. A series of operations comprising negative pressure arrangement and time arrangement are conducted by the keyboard conveniently. In addition, all the operation and data is displayed.

The invention discloses an external medicinal composition for treating chronic osteomyelitis. The external medicinal composition for treating the chronic osteomyelitis is prepared from active ingredients and a pharmaceutic adjuvant, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight: 21-30 parts of Chinese violet, 15-26 parts of pagoda tree pod, 6-12 parts of szechwan lovage rhizome, 6-12 parts of stephania terandra and 18-30 parts of coptis chinensis. After the external medicinal composition disclosed by the invention is used for treating the chronic osteomyelitis, recovery of a bone structure of a sicken limb is in a progressive course, and combined action of the external medicinal composition for treating the chronic osteomyelitis for controlling infection and promoting bone regeneration is obviously better than pure anti-infection effect of antibiotic.

A bone regenerative composition includes a resorbable osteoconductive matrix and a multiplicity of substantially rigid nanofibers dispersed within structure of the matrix to impart structural integrity with nanofiber ends projecting out of a surface of the matrix to provide differential load bearing surface bristles.

A bone graft substitute for use in orthopedic bone grafting procedures comprising a radiolucent bone graft substitute combined with a temporary radiopaque agent. Methods of making and using the composition are also disclosed. Bone graft substitutes have become an effective means of regenerating bone in orthopedic procedures where bone loss results from surgically created defects or traumatic injury to the bone. Bone graft substitutes include mineral-based materials such as hydroxyapatite, calcium phosphates, and calcium phosphosilicates as well as allograft-derived materials and xenograft-derived materials such as collagen-based matrices and demineralized bone matrices.

The invention relates to the technical field of tissue engineering and biological manufacturing, in particular to a chitosan-human recombinant collagen electrostatic spinning nanofiber scaffold and apreparation method. The specific preparation method comprises the following steps: preparing a hexafluoroisopropanol spinning solution with a certain concentration from three components, namely humanrecombinant collagen, chitosan and polycaprolactone according to a certain ratio; and preparing chitosan, humanized recombinant collagen and polycaprolactone electrostatic spinning nanofiber scaffoldsfrom the prepared solution through an electrostatic spinning technology, then cross-linking the nanofiber scaffolds through a cross-linking agent, and applying the cross-linked scaffolds to cartilagetissue regeneration. The chitosan-human recombinant collagen electrostatic spinning nanofiber scaffold prepared by the invention has high fiber morphology, high biocompatibility and biodegradability,has the capability of guiding cartilage regeneration, is remarkable in effect, and can be used for repairing cartilage tissue defects.