72 results about "Bone regeneration" patented technology

This invention is related to bone fillers, hard tissue supporting films and three dimensional scaffolds that contains composite particle of inorganic compound/water soluble polymer (such as β-TCP/Gelatin), that can lead to bone regeneration and release an antibacterial or bioactive agent at the defect area. The bone regenerative hard tissue supporting films and scaffolds were obtained by addition of antibacterial or bioactive agent loaded composite particles into biodegrable polymer (such as PCL) matrix.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillo facial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and/or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca_1-XM_XHPO₄, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and/or bioactive silica glasses and gels.

The invention provides a polyether-ether-ketone material and a modification method based on plasma immersion ion implantation and application. The modification method comprises the steps: depositing a diamond-like film on the surface of the polyether-ether-ketone material by the plasma immersion ion implantation technique or depositing the diamond-like film and introducing nitrogen-containing active functional groups, and thus obtaining a surface-modified polyether-ether-ketone material. The surface-modified polyether-ether-ketone material can be applied to the fields such as medical regeneration materials, functional materials, bioactive materials, etc. The modification method does not reduce the excellent mechanical property of main materials while greatly improving the biological activity of the surface of the polyether-ether-ketone material, therefore, the polyether-ether-ketone material has excellent biocompatibility and achieves the effect of repairing bone defects while promoting the regeneration function of new bones. The surface modification method based on the plasma immersion ion implantation technique has the advantages of simple process, low cost and mass production and benefits industrial production.

The invention discloses a growth factor nanotube slow-release system used for osseointegration and a preparation method and application thereof, the nanotube slow-release system includes a titanium alloy implant, a titanium dioxide nanotube coating is prepared on the titanium alloy implant surface by the method of anodic oxidation, and the titanium alloy implant is loaded with a growth factor. The growth factor nanotube slow-release system has the advantages that: (1) the growth factor nanotube slow-release system can improve the nanotube drug loading amount by a simple and effective method of vacuum aspiration; (2) the invention also provides a rhPDGF- BB nanotube slow-release system which can significantly promote the osseointegration in bone osteoporosis state, rhPDGF-BB is approved by the FDA to be used in clinical osteanagenesis therapies, and clinical application of the nanotube slow-release system may be provided; and (3) including nanotube preparation, therowth factor nanotube slow-release system is in no need of special, complex and expensive equipment, simple in operation process, and conducive to the promotion and use.

A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and/or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.

Tunnel bone grafting according to the proposed method can be used when an individual has a facial bone defect due to periodontal disease, cleft palate or trauma. The proposed method can be utilized for implant placement, it reduces wrinkles and supports facial muscle in order to make the individual look younger. The method can also be used to create a thicker alveolar ridge in order to stabilize full dentures or partial dentures. Its advantages over conventional guided bone regeneration techniques is that the proposed method is minimally invasive and lessens trauma to patients, prevents soft tissue opening, and reduces surgery time. Specifically, it minimizes the incision size and thus reduces trauma to the patient. Further, this reduces the risk of complications, including excessive bleeding, due to the minimization of the incision size. There is also considerable reduction in post surgery swelling using the proposed method as opposed to conventional techniques.

Various porous implantable interbody or spinal fusion devices, which may be formed of metal, metal alloy or polymer are provided. These porous implantable interbody devices may be engineered to have a porous network or scaffold structure for repairing and/or replacing damaged bone segments in the spine while allowing better fusion for improved bone healing and bone regrowth.

The invention belongs to the technical field of glass bone restoration, and discloses a porous biological activity glass bone restoration material, a preparation method and application thereof. Aftera prepared porous biological activity glass bone restoration material being implanted into an organism, the biocompatibility is good; the prepared bone restoration material is composed of natural macromolecular materials and inorganic materials being bone-like components, the surface of the prepared bone restoration material is capable of forming a good interface relation with cells, any parts ofany bone defect can be implanted in a orthopedic surgery, application parts are not limited, good biocompatibility, no cytotoxicity and no immune rejection are achieved. According to the prepared bonerestoration material adopted by the preparation method, good degradation performance is achieved, materials are gradually degraded with growth of new bone, and thus no occupation and no interfere tobone reconstruction are achieved; and the restoration cycle is shortened.

The invention discloses a method for constructing tissue engineered cartilages in vivo, which comprises the following steps: carrying out multiplication culture on a great deal of auricular cartilage cells in vitro; preparing a stratified cartilage cell membrane; preparing a PLC (three-dimensional printing) inner core with a special form; preparing a sandwich mode of the stratified cartilage cell membrane and a material; and performing an operation for implanting a compound containing the membrane and the inner core into animal muscle. According to the method, a three-dimensional printed material is used as an inner core scaffold, and the material is coated by the cell membrane to prevent the scaffold material from being in direct contact with in vivo tissue, thereby reducing the inflammatory reaction caused by the scaffold material in vivo and increasing the success ratio of cartilage regeneration in vivo. In addition, through three-dimensional printing, inner core materials with various special forms can be manufactured, and tissue engineered cartilages corresponding to the inner core materials are constructed; and meanwhile, by adjusting the height of a printing layer, the density of grids and the mode of wiring, due to different superimposed layers of the membrane, the constructed cartilages have different mechanical strength which can reach a relatively high level.

The invention discloses a bioactivity glass porous bone repair material and a preparation method thereof. The method includes: using a sol-gel method to prepare bioactivity glass powder, evenly mixingthe bioactivity glass powder, a binder and a pore-forming agent, performing compression molding, performing isostatic cool pressing, and performing thermal treatment sintering to remove the pore-forming agent so as to obtain the 58S bioactivity glass porous bone repair material. The bioactivity glass porous bone repair material and the preparation method have the advantages that the pore diameterof the prepared bone repair material is about 50-300 micrometers, the porosity of the prepared bone material can be controlled to be 40-70%, and the prepared bone repair material which has the mechanical performance similar to cancellous bones is good in pore diameter uniformity, good in surface smoothness, controllable in degradation rate and applicable to bone defect repair and bone tissue regeneration; meanwhile, the preparation method is simple in process, easy in raw material obtaining, low in cost and easy to achieve industrialization.

The invention belongs to the field of biomedical engineering, and discloses a preparation method of an osteanagenesis material. The preparation method comprises the steps of (1) enabling chitosan andpolyoxyethylene to completely dissolve in a 90v/v% acetous solution, and performing uniform stirring to obtain spinning liquid; (2) performing electrostatic spinning with the spinning liquid to obtainchitosan/polyoxyethylene nanofibers; (2) washing the chitosan/polyoxyethylene nanofibers with a DMEM culture medium to be neutral, performing drying, then performing treatment with a plasma processorand performing activating; and (4) soaking activated nanofibers in the DMEM culture medium containing bone growth factors and epigallocatechin gallate ester/carotenoid liposome, performing negative pressure flash explosion, performing a grafting reaction, performing centrifugation and performing freeze-drying. According to the osteanagenesis material prepared by the preparation method, the bone growth healing speed can be effectively increased.

Provided herein are a membrane-type artificial scaffold for guided bone regeneration (GBR) and a method for fabricating the same. The membrane-type artificial scaffold according to the present invention comprises: a first layer made of at least one fiber layer arranged in parallel with each other with a first spacing therebetween such that the fiber layer contacts a bone tissue in vivo; and a second layer stacked on the first layer and made of at least one fiber layer arranged parallel to each other with a second spacing therebetween such that the fiber layer contacts a soft tissue in vivo. The first spacing is larger than the second spacing.

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.

The invention discloses an external medicinal composition for treating chronic osteomyelitis. The external medicinal composition for treating the chronic osteomyelitis is prepared from active ingredients and a pharmaceutic adjuvant, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight: 21-30 parts of Chinese violet, 15-26 parts of pagoda tree pod, 6-12 parts of szechwan lovage rhizome, 6-12 parts of stephania terandra and 18-30 parts of coptis chinensis. After the external medicinal composition disclosed by the invention is used for treating the chronic osteomyelitis, recovery of a bone structure of a sicken limb is in a progressive course, and combined action of the external medicinal composition for treating the chronic osteomyelitis for controlling infection and promoting bone regeneration is obviously better than pure anti-infection effect of antibiotic.

The invention discloses an application of a Chinese medicinal composition containing components for invigorating spleen and reducing phlegm in preparing a medicine for treating early and medium stage femoral head necrosis. The Chinese medicinal composition is made from the following bulk drugs in parts by weight: 10-20 parts of tuckahoe, 5-15 parts of cassia twig, 10-20 parts of largehead atractylodes, 3-9 parts of liquorice, 5-15 parts of rhizoma pinelliae preparata, 15-25 parts of pilose asiabell root, 5-15 parts of angelica, 5-15 parts of chuanxiong rhizome, 10-20 parts of prepared rehmannia root, 6-18 parts of red peony root, 15-25 parts of ground beetle and 15-25 parts of colla cornus cervi. The Chinese medicinal composition has efficacies of invigorating spleen and reducing phlegm, activating blood circulation and clearing the channels, nourishing kidney and promoting bone regeneration and the like, has obvious effects on improving symptoms of a patient, postponing progress of the disease and enhancing quality of life, and has particularly good effect on the patient with early and medium stage femoral head necrosis; and the Chinese medicinal composition has small toxic and side effects and low price.

The invention discloses a bone tissue engineering stent. The bone tissue engineering stent comprises a hollow latticed stent and a porous zinc-based metal ball, wherein the hollow latticed stent is filled with the porous zinc-based metal ball, the porous zinc-based metal ball can be a solid ball of which the surface is provided with hole grooves and also be a fluffy ball formed by rolling a metalwire; the stent is also provided with internal supporting columns to provide an excellent mechanical property; the stent can be filled with beta-TCP particles to be enriched in bone marrow mesenchymlstem cells. Combined with the latticed stent prepared from titanium or zinc-based metal and the internal supporting columns of the latticed stent, the bone tissue engineering stent with the excellentmechanical property is prepared, the porous zinc-based metal ball in the bone tissue engineering stent can promote osteogenic differentiation, inhibit osteoclast differentiation, promote the regeneration and ingrowth of bone tissue while providing the support, and then is replaced by the bone tissue during degradation, and the beta-TCP particles can be enriched in the bone marrow mesenchyml stem cells and promote bone repair. The bone tissue engineering stent can be applied to the large-segment bone defect of a weight-bearing part, promote bone tissue regeneration on the basis of mechanical support, and achieve the curative effect of repairing the large-segment bone defect.

The present invention provides a cell preparation that can be prepared from cells collected from a patient of any age group, and that has an excellent bone tissue regenerative capacity and is effective for bone tissue regeneration. Undifferentiated osteoblasts obtained from alveolar bone, particularly those obtained by being cultured after the enzyme treatment of alveolar bone have a remarkable bone tissue regenerative capacity, and are therefore useful for a cell preparation for bone tissue regeneration.