Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

External medicinal composition for treating chronic osteomyelitis and application thereof

A technology of chronic osteomyelitis and topical drugs, applied in the field of traditional Chinese medicine, can solve problems such as difficult to completely eliminate infection, achieve the effects of improving the body's immune function, improving tissue repair, and controlling local infection

Inactive Publication Date: 2014-07-23
杨献华
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional treatment methods are at least 4-6 weeks of intravenous antibiotics and facial debridement. However, in chronic osteomyelitis, the diseased tissue is surrounded by infected sequestrum, and the infection focus is surrounded by hardened and relatively ischemic bone. It is difficult to completely eliminate the infection with antibiotics

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • External medicinal composition for treating chronic osteomyelitis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Weigh 0.25kg of Viola chinensis, 0.20kg of Huaijiao, 0.09kg of Rhizoma Chuanxiong, 0.09kg of Fangji and 0.23kg of Coptis chinensis and combine them, add water to decoct twice, add water for the first time to 10 times the weight of the medicinal materials, decoct for 2 hours, and decoct for the second time Add water for 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, concentrate under reduced pressure at 0.08MPa and 70°C until the relative density is 1.15 at 70°C, add 95% (v / v) ethanol to make the alcohol content reach 85% (v / v), stir, stand overnight, filter, the filtrate is concentrated under reduced pressure at 0.08MPa to obtain an extract with a relative density of 1.15g / mL at 65°C, put the extract in a stainless steel plate, and vacuum dry (below 60°C) into a dry paste, crushed; slowly add 10g of carbomer to about 500ml of distilled water, stir while adding until a transparent gel matrix is ​​formed, dissolve 1.5g of dry p...

Embodiment 2

[0016] Weigh 0.21kg of Viola chinensis, 0.20kg of Huaijiao, 0.12kg of Rhizoma Chuanxiong, 0.06kg of Fangji and 0.20kg of Coptis chinensis and combine them, add water to decoct twice, the first time add water to 10 times the weight of the medicinal materials, decoct for 2 hours, and the second Add water for 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, concentrate under reduced pressure at 0.08MPa and 70°C until the relative density is 1.15 at 70°C, add 95% (v / v) ethanol to make the alcohol content reach 85% (v / v), stir, stand overnight, filter, the filtrate is concentrated under reduced pressure at 0.08MPa to obtain an extract with a relative density of 1.15g / mL at 65°C, put the extract in a stainless steel plate, and vacuum dry (below 60°C) into a dry paste, crushed; slowly add 10g of carbomer to about 500ml of distilled water, stir while adding until a transparent gel matrix is ​​formed, dissolve 1.5g of dry paste powder in an ap...

Embodiment 3

[0018] Weigh 0.28kg of Viola chinensis, 0.26kg of Huaijiao, 0.08kg of Chuanxiong, 0.10kg of Fangji and 0.30kg of Coptis chinensis and combine them, add water to decoct twice, the first time add water to 10 times the weight of the medicinal materials, decoct for 2 hours, and the second Add water for 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, concentrate under reduced pressure at 0.08MPa and 70°C until the relative density is 1.15 at 70°C, add 95% (v / v) ethanol to make the alcohol content reach 75% (v / v), stir, stand overnight, filter, the filtrate is concentrated at 0.08MPa under reduced pressure to obtain an extract with a relative density of 1.15g / m at 65°C, put the extract in a stainless steel plate, and vacuum dry (below 60°C) into a dry paste, crushed; slowly add 10g of carbomer to about 500ml of distilled water, stir while adding until a transparent gel matrix is ​​formed, dissolve 1.5g of dry paste powder in an appropriate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an external medicinal composition for treating chronic osteomyelitis. The external medicinal composition for treating the chronic osteomyelitis is prepared from active ingredients and a pharmaceutic adjuvant, wherein the active ingredients are prepared from the following traditional Chinese medicinal raw materials in parts by weight: 21-30 parts of Chinese violet, 15-26 parts of pagoda tree pod, 6-12 parts of szechwan lovage rhizome, 6-12 parts of stephania terandra and 18-30 parts of coptis chinensis. After the external medicinal composition disclosed by the invention is used for treating the chronic osteomyelitis, recovery of a bone structure of a sicken limb is in a progressive course, and combined action of the external medicinal composition for treating the chronic osteomyelitis for controlling infection and promoting bone regeneration is obviously better than pure anti-infection effect of antibiotic.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to an external pharmaceutical composition for treating chronic osteomyelitis and its application. Background technique [0002] Chronic osteomyelitis is a refractory orthopedic disease with high incidence, deep disease location, severe condition, long course of disease, poor curative effect, and easy recurrence, which seriously damages the physical and mental health of patients. The traditional treatment methods are at least 4-6 weeks of intravenous antibiotics and facial debridement. However, in chronic osteomyelitis, the diseased tissue is surrounded by infected sequestrum, and the infection focus is surrounded by hardened and relatively ischemic bone. It is difficult to completely eliminate the infection with antibiotics. Contents of the invention [0003] In view of the deficiencies in the prior art, the purpose of the present invention is to ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/86A61K9/06A61P19/08
Inventor 董健王钰凌
Owner 杨献华
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com