Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

145results about How to "Enhance immune function" patented technology

Probiotic microcapsule with function of improving intestinal microecology and key technology

The invention relates to the technical field of biological pharmacy, and discloses a probiotic microcapsule with a function of improving intestinal microecology, which comprises the following components in percentage by weight: lactobacillus rhamnosus: each gram of formula contains 1010 CFU of lactobacillus rhamnosus; lactobacillus acidophilus: each gram of the formula contains 109 CFU; clostridium butyricum: each gram of the formula contains 108 CFU; 5%-8% of a nano sodium alginate-chitosan compound; 3%-5% of peptide nanoparticles; 2%-4% of a natural polymer intelligent response film; 3%-6% of arabinoxylan oligosaccharide; 4%-7% of resistant dextran; 2%-4% of lentinan; and 0.1%-0.3% of resveratrol. Through a double-layer or three-layer embedding technology of the nano sodium alginate-chitosan compound and the intelligent response polymer film, the tolerance of the probiotics in gastric acid and cholate environments is remarkably enhanced, and targeted release of the probiotics in small intestines and colon is ensured.
Owner:HENAN BUSINESS SCI RES INST

Bifidobacterium animalis subsp. Lactis BLa79 as well as application, product and method thereof

The invention discloses bifidobacterium animalis subsp. Lactis BLa79 as well as application, a product and a method thereof, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium animalis subsp. Lactis BLa79 is CGMCC (China General Microbiological Culture Collection Center) NO. 32426, and the preservation number of the bifidobacterium animalis subsp. Lactis BLa79 is CGMCC NO. 32426. Based on the strain, the invention also provides application and related products of the strain. The BLa79 strain has broad-spectrum antibacterial performance, has the function of regulating intestinal flora, can effectively relieve ulcerative colitis, and can relieve colitis by increasing body weight, reducing DAI score, reducing spleen index, inhibiting colonic atrophy, reducing proinflammatory factor level and promoting SIgA secretion.
Owner:JIANGSU WECARE BIOTECHNOLOGY CO LTD

Metabolite screening method for promoting expression of porcine intestinal defensin pBD1 and application of metabolite screening method

The invention discloses a metabolite screening method for promoting expression of porcine intestinal defensin pBD1 and application of the metabolite screening method. The screening method comprises the following steps: 1) constructing a porcine defensin pBD1 gene fluorescence report intestinal epithelial cell line; 2) evaluating the promotion effects of different metabolites based on the pBD1 gene fluorescence report intestinal epithelial cell line; and 3) further evaluating the promotion effects of the metabolites screened in the step 2) based on a porcine intestinal epithelial cell IPEC-J2 model. And 4) further evaluating the promotion effect of the metabolite screened in the step 3) based on the pig intestinal organ. The invention can be used for preparing or screening drugs influencing the expression of the porcine intestinal defensin pBD1. According to the application disclosed by the invention, the effect of the D-malic acid for improving the immune function of the pig intestinal tract by promoting the expression of the defensin pBD1 is found for the first time, verification is carried out on a pig intestinal tract organ-like model, and meanwhile, the optimal treatment concentration of the D-malic acid for promoting the expression of the defensin pBD1 in the pig intestinal tract is optimized.
Owner:ZHEJIANG UNIV

Lactobacillus plantarum TY-P23 and application thereof

PendingCN119351264AImprove immune organ indexInhibit atrophyBacteriaDigestive systemBiotechnologyMicroorganism
The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus plantarum TY-P23 and application thereof, and the preservation number of the lactobacillus plantarum TY-P23 is CGMCC No: 30876. The lactobacillus plantarum TY-P23 has the functions of remarkably improving the immunity of the body and improving the intestinal injury of the body.
Owner:CHONGQING TIANYOU DAIRY CO LTD

Formula of pet food for strengthening intestines and balancing nutrition for pets

The invention relates to the technical field of pet food, and particularly discloses a pet food formula for strengthening intestines and balancing nutrition for pets, the pet food formula comprises the following raw materials: meat, vegetables, fruits, whole goat milk powder, Maillard reaction products, composite algae powder, yucca powder and synbiotics microcapsules; the preparation method comprises the following steps: respectively crushing the meat, the vegetables and the fruits; stirring and mixing the meat paste, the vegetable paste, the fruit paste, the whole goat milk powder, the composite algae powder, the yucca powder and the synbiotics microcapsules to obtain a mixed material; placing the mixed material in an extruder to prepare cylindrical particles; spraying the Maillard reaction product on the surfaces of the particles by adopting vacuum spraying equipment; the sprayed particles are fed into a freeze-drying bin to be freeze-dried; and packaging the frozen freeze-dried particles into bags to obtain the pet food capable of strengthening the intestines and being balanced in nutrition. The formula of the pet food capable of strengthening the intestines and balancing the nutrition has remarkable effects in the aspects of improving the health of the intestines, guaranteeing the balanced nutrition, improving the appetite of the pets and the like.
Owner:深圳海珹科技有限公司

Bactericidal composition for asparagus stem blight

The invention relates to a bactericidal composition for asparagus stem blight, which belongs to the technical field of asparagus stem blight and has good prevention, protection and treatment effects. According to the action mechanism, normal growth of pathogenic bacteria is interfered by inhibiting biosynthesis of ergosterol, a good inhibiting effect on pathogenic bacteria of various plants is achieved, and meanwhile, difenoconazole also has a strong inhibiting effect on spore formation of the pathogenic bacteria of the plants; the chitosan oligosaccharide, the carbendazim, the Chinese herbal medicine active extract, the methanol extract, the plant extract, the difenoconazole, the lentinan and the amino-oligosaccharin lentinan mixed preparation have a good prevention and treatment effect on the asparagus stem blight and can block combination of pathogens and sugar molecules on the surfaces of normal cells through an adhesion effect, so that the infection path of the asparagus stem blight is blocked. The lentinan has potential value in the aspect of preventing and treating the asparagus stem blight, and the lentinan enhances the immune function and blocks the pathogen infection pathway.
Owner:INST OF PLANT PROTECTION JIANGXI ACAD OF AGRI SCI

Application of bifidobacterium breve BB990 in metabolism field

The invention belongs to the technical field of biological medicines, discloses application of bifidobacterium breve BB990 in the field of metabolism, and particularly discloses bifidobacterium breve BB990 which is preserved in Guangdong Microorganism Culture Collection Center, the preservation number is GDMCC No.63259, and the preservation date is March 10, 2023. The invention further discloses a preparation method of the bifidobacterium breve BB990. The bifidobacterium breve BB990 provided by the invention has the effects of regulating gastrointestinal disorder, enhancing intestinal immune function, inhibiting harmful bacteria, improving intestinal flora structure, maintaining intestinal steady state, regulating immunity, improving immune curative effect, regulating body glycometabolism and liver metabolism and the like. Experiments prove that the bifidobacterium breve BB990 can effectively prevent and treat metabolic diseases, such as non-alcoholic fatty liver, type II diabetes and the like, the treatment effect of the bifidobacterium breve BB990 is remarkably superior to that of other bifidobacterium breve (such as bifidobacterium breve 206), and the bifidobacterium breve BB990 has a good prospect.
Owner:GUANGDONG LONGSEE BIOMEDICAL CO LTD

Immunoregulation-based stem cell preparation as well as preparation method and application thereof

The invention belongs to the technical field of biological medicine, and particularly relates to a stem cell preparation based on immunoregulation and a preparation method and application thereof. The stem cell preparation based on immunoregulation is prepared from the following raw materials in parts by weight: 5 to 40 parts of freeze-dried powder, 40 to 120 parts of gastrodia elata polysaccharide and 2 to 6 parts of melatonin, the freeze-dried powder is obtained by mixing and freeze-drying a stem cell culture solution and curcumin lipidosome; the volume ratio of the stem cell culture solution to the curcumin liposome is 1: (10-32); the protein concentration in the stem cell culture solution is 1.2 mg / mL to 1.6 mg / mL. The stem cell preparation provided by the invention can utilize the immune regulation effect of the mesenchymal stem cells to realize the immune repair of adipose tissues.
Owner:SHAANXI ZHONGHONG KERUI REGENERATIVE MEDICINE RES INST CO LTD

Lactobacillus crispatus capable of promoting female genital tract health and delaying genital tract immune aging

The invention discloses lactobacillus crispatus for improving female genital tract microenvironment and immune aging and application of the lactobacillus crispatus, and belongs to the field of probiotics. The probiotic lactobacillus crispatus ProSci-38 disclosed by the invention can be used for effectively improving the symptoms such as pruritus vulvae, causalgia of vagina, abnormal vaginal secretion and the like of patients with vaginitis; mainly through the effect of intestinal tract-vaginal axis, the proportion of lactobacillus is increased, the proportion of harmful bacteria is reduced, the balance of vaginal flora is recovered, and the acidic environment of vagina is maintained; meanwhile, the inflammatory factor level can be reduced, the immune function of the vagina of a patient can be improved, so that the vagina environment is improved, the infection risk is reduced, and the preparation method has a great prospect in preparation of products for relieving and / or treating vaginitis.
Owner:BEIJING SCITOP BIO TECH CO LTD

A Chinese medicine composition for treating allergic rhinitis and its preparation method and application

ActiveCN118384202Breduce usageAlleviate allergy symptomsOrganic active ingredientsAntipyreticIncreased inflammatory responseT cell
The present invention proposes a Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof, which belong to the field of pharmaceutical technology. Ag-graphene oxide is adsorbed on in vitro proliferated γδT cells, a Chinese medicine fermentation product obtained by fermentation and extraction of Xanthium sibiricum, Astragalus, Poria, Magnolia officinalis, and Mentha is prepared, berberine and quercetin are prepared into eutectic powder, the three are mixed and added into water, probiotics, carboxymethyl chitosan, poloxamer 407 and poloxamer 188 are added, and mixed evenly to prepare a Chinese medicine composition for treating allergic rhinitis, which has a good effect of improving allergic rhinitis, adopts a method of combining traditional Chinese and Western medicine, reduces inflammatory response, enhances the immune function of patients, improves the clinical symptoms of patients with allergic rhinitis, reduces the long-term recurrence rate, reduces the use of drugs, improves the quality of life, and reduces the risk of developing asthma, and has broad application prospects.
Owner:BEI CHUANG KAIYUAN (BEIJING) PHARM TECH CO LTD

Eucheuma compound for improving lung function and preparation method thereof

The invention provides an eucheuma compound for improving lung function and a preparation method thereof. The eucheuma compound is prepared from the following raw materials in parts by weight: 25 to 35 parts of eucheuma extract, 13 to 17 parts of oyster peptide, 8 to 12 parts of fish collagen peptide, 4 to 6 parts of rhizoma polygonati, 3 to 5 parts of herba cistanche, 2 to 4 parts of semen euryales and 1 to 2 parts of longan. Secondly, the eucheuma extract rich in eucheuma polysaccharide, eucheuma polypeptide and the like is prepared through the technology. The components in the formula of the eucheuma compound have a synergistic effect, and the prepared eucheuma compound can effectively control the lung coefficient and increase of the hydroxyproline content in lung tissue and improve inflammatory infiltration and fibrohyperplasia of the lung. In addition, the compound also inhibits oxidative stress reaction and further inhibits pulmonary fibrosis; the lung lesion is effectively inhibited, the lung function is improved, and the lung health is promoted.
Owner:HAINAN YUNHAO BIOLOGICAL TECH CO LTD

A Chinese medicine composition having the effect of enhancing immune function and its preparation method

The invention discloses a Chinese medicine composition with the function of enhancing immune function and a preparation method thereof; the Chinese medicine composition is composed of one or more of parts A to F; wherein the weight proportions of the medicinal materials in parts A to F are as follows: part A comprises 1 to 50 parts of astragalus, 1 to 50 parts of ginseng, and 1 to 50 parts of codonopsis; part B comprises 1 to 40 parts of angelica, 1 to 40 parts of jujube, and 1 to 40 parts of longan pulp; part C comprises 1 to 30 parts of cistanche, 1 to 30 parts of eucommia leaf, 1 to 30 parts of alpinia oxyphylla, and 1 to 30 parts of ginseng seed. ~30 parts; Part D includes 1~20 parts of lily, 1~20 parts of polygonatum, 1~20 parts of wolfberry, and 1~20 parts of mulberry; Part E includes 1~20 parts of cornus and 1~20 parts of raspberry; Part F includes 1~10 parts of tuckahoe, 1~10 parts of yam, 1~10 parts of hawthorn, and 1~10 parts of tangerine peel; the Chinese medicine composition can be made into solid beverages, compressed candies, pastes, honey pills, functional jellies, biscuits, etc. in food after extraction or crushing and adding appropriate pharmaceutical excipients. The Chinese medicine composition has strong effects of strengthening the body, strengthening the spleen and lungs, and replenishing qi and blood, can effectively enhance immunity and improve physical fitness, and provides patients with a safe and effective pure Chinese medicine rehabilitation food.
Owner:HANGZHOU HEYON PHARM TECH CO LTD

Agkistrodon halys peptide composite probiotic solid beverage and preparation method thereof

The invention discloses an agkistrodon halys peptide composite probiotic solid beverage and a preparation method of the agkistrodon halys peptide composite probiotic solid beverage. Comprising the following raw materials in parts by weight: 12 to 17 parts of ginseng oligopeptide powder, 12 to 17 parts of soybean oligopeptide powder, 5 to 10 parts of agkistrodon halys peptide powder, 10 to 15 parts of ganoderan, 15 to 20 parts of fructo-oligosaccharide, 15 to 20 parts of glucose, 8 to 12 parts of cranberry powder, 0.5 to 1.5 parts of anhydrous citric acid, 5 to 10 parts of bifidobacterium bifidum BGN4, 7 to 13 parts of gamma-aminobutyric acid, 5 to 10 parts of yeast beta-glucan and 0.04 to 0.07 part of vitamin E. According to the solid beverage, various active peptides such as the agkistrodon halys peptide, the ginseng oligopeptide and the soybean oligopeptide are compounded with the probiotics and the dietary fibers, the bioavailability of all the components is improved, absorption of peptide substances can be promoted through the activity of the probiotics, and meanwhile the immunity of the organism can be remarkably enhanced through the synergistic effect of various functional components.
Owner:ZHONGQI TIEJUN GROUP CO LTD

Red ginseng extract special care essence and preparation method thereof

The invention provides a red ginseng extract special care essence and a preparation method thereof, and a red ginseng extract composition. The red ginseng extract composition comprises a red ginseng extract, deer bone collagen peptide, a red camellia extract, beta-nicotinamide mononucleotide, a rose extract, a moutan bark extract and a ligusticum wallichii extract. According to the invention, the red ginseng extract, the deer bone collagen peptide, the red camellia flower extract, the beta-nicotinamide mononucleotide, the rose flower extract, the moutan bark extract and the ligusticum wallichii extract are adopted, so that the prepared special care essence with the red ginseng extract has better oxidation resistance and aging resistance.
Owner:YANBIAN TANJUN BIOTECH

Galactomanninotetraose with anti-tumor activity and application of galactomanninotetraose

The invention relates to galactomannan tetrasaccharide with anti-tumor activity and application of the galactomannan tetrasaccharide, and belongs to the technical field of active oligosaccharide drugs. The galactomanninotetraose ACP-3 synthesized by the invention has a good anti-tumor effect, is effective and safe, and has a very good development value. The galactomanninotetraose ACP-3 can obviously inhibit tumor cell proliferation in vitro and has no obvious toxicity to normal cells, so that the antitumor effect of the galactomanninotetraose ACP-3 has selectivity. In-vivo anti-tumor experiments show that the immunologic function of a body can be improved and tumor growth can be inhibited by single administration of the galactomanninotetraose ACP-3, and the galactomanninotetraose ACP-3 and CTX or PTX are combined for use, so that the effects of enhancing effects and reducing toxicity are achieved. The invention is helpful for developing oligosaccharide drugs with anti-tumor effect, and has important significance for research and development of corresponding carbohydrate drugs.
Owner:SHANDONG UNIV

Application of bacillus subtilis QST713 in improving production performance and reproduction traits of Xiaoshan chicken

The invention discloses application of bacillus subtilis QST713 in improving the production performance and reproduction traits of Xiaoshan chickens. The production performance of the Xiaoshan chickens is improved by any one or more than two of the following steps: (1) reducing the feed-egg ratio of the Xiaoshan chickens; (2) the egg weight of Xiaoshan chicken is increased; (3) the egg protein height of Xiaoshan chicken is increased; (4) increasing any one or more of total protein, globulin and albumin in serum of the Xiaoshan chicken; (5) reducing any one or more of cholesterol, triglyceride, glutamic oxalacetic transaminase, glutamic-pyruvic transaminase and low-density lipoprotein in serum of the Xiaoshan chicken; and (6) increasing any one or more of immune globulin A, immune globulin G and immune globulin M in the serum of the Xiaoshan chicken. By adding the bacillus subtilis QST713 strain, the feed-egg ratio of the Xiaoshan chicken can be remarkably reduced, the egg quality and serum biochemical indexes of the Xiaoshan chicken can be effectively improved, the immune function is enhanced, and the ovarian gene expression of the Xiaoshan chicken is influenced.
Owner:ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES

Bifidobacterium breve BBr37 with hypoglycemic capacity and application, product and method thereof

The invention discloses bifidobacterium breve with hypoglycemic capacity and application, a product and a method thereof, and belongs to the technical field of microorganisms. The invention provides a bifidobacterium breve (Bifidobacterium breve) strain BBr37 with the blood sugar reducing capacity, and the preservation number of the bifidobacterium breve strain BBr37 is CGMCC (China General Microbiological Culture Collection Center) NO.32423. The invention also provides an application of the strain BBr37 in preparation of hypoglycemic drugs or health-care foods with an auxiliary hypoglycemic function or bacteriostatic agents or non-treatment-destination bacteriostasis, and a product and a method based on the strain BBr37. The strain BBr37 disclosed by the invention has a relatively strong inhibition effect on escherichia coli, staphylococcus aureus, salmonella, haemophilus parasuis, haemophilus parainfluenza, campylobacter jejuni and enterocolitis yarrowia, and can effectively achieve the effects of reducing blood sugar and regulating intestinal flora.
Owner:JIANGSU WECARE BIOTECHNOLOGY CO LTD

Pediococcus acidilactici ZKPa1222, astragalus mongholicus fermentation liquor thereof and application of pediococcus acidilactici ZKPa1222 in aspect of improving immunity

The invention relates to the technical field of probiotics, in particular to pediococcus acidilactici ZKPa1222, astragalus mongholicus fermentation liquor of the pediococcus acidilactici ZKPa1222 and application of the pediococcus acidilactici ZKPa1222 in the aspect of improving immunity, the pediococcus acidilactici ZKPa1222 is preserved in China General Microbiological Culture Collection Center on May 13, 2024, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, the preservation number is CGMCC No.30548, and the preservation number is CGMCC No.30548. The invention further discloses a preparation method of the pediococcus acidilactici ZKPa1222. According to the invention, the pediococcus acidilactici ZKPa1222 is used for directly fermenting the radix astragali extracting solution, so that the fermentation process is simplified, and the fermentation efficiency is improved.
Owner:SHANDONG ZHONGWEI ZHONGKANG BIOTECHNOLOGY CO LTD +1

Fatty cream composition for maligant splanchnocoele hydrops and its preparing method

The present invention relates to a composition of aliphatic emulsion preparation for malignant thoracicoabdominal hydrops and its preparation method. It is made up by adopting pure natural anticancer medicine elemene and at least one polysaccharide selected from ginseng polysaccharide, astragalus polysaccharide, acanthopanax polysaccharide and lyceum polysaccharide as raw material. Said invention can obviously raise solubility of medicine, increase stability of medicine, effectively remove and kill cancer cells and raise immunity of body.
Owner:SINOPHARM A THINK PHARMA

Application of small-molecule active peptide ring in enhancing plant immune function

The invention discloses an application of a small-molecule active peptide ring in enhancing plant immune function, the small-molecule active peptide ring is a ring (valine-proline), the active peptide can efficiently trigger rice immune response, including release of active oxygen, deposition of callose and up-regulation of expression of immune related genes, and the active peptide ring can effectively trigger the immune response of rice. Therefore, the disease resistance of the rice is improved. Compared with a traditional chemical pesticide, the cyclo (valine-proline) serving as a biological agent has the characteristics of environmental friendliness and no chemical residue, and a new solution is provided for agricultural sustainable development.
Owner:ZHEJIANG UNIV OF TECH

A polysaccharide from momordica grosvenori swingle root and a preparation method and application thereof

The application provides a momordica root polysaccharide and a preparation method and application thereof, and belongs to the technical field of natural product development. The preparation method of the momordica root polysaccharide comprises the following steps: drying and crushing momordica roots, and removing fat by ethanol reflux; after water extraction and alcohol precipitation, and removing protein, a momordica root crude polysaccharide is obtained; and the momordica root crude polysaccharide is sequentially separated and purified by DEAE-52 cellulose column and Sephadex LH20 gel column to obtain the momordica root refined polysaccharide. The preparation method has the advantages that the polysaccharide obtained by directly extracting water in the prior art has a narrow molecular weight distribution range and better immune enhancement activity. Experimental results show that the momordica root polysaccharide can stimulate RAW264.7 cells to secrete NO, TNF-alpha and IL-6 factors, enhance the phagocytosis of RAW264.7 cells, and thus enhance the cell immune function, and can be applied to the development of products for improving immunity.
Owner:GUANGXI INST OF BOTANY THE CHINESE ACAD OF SCI

Solid beverage capable of reducing blood pressure and preparation method of solid beverage

The invention discloses a solid beverage capable of reducing blood pressure and a preparation method thereof. The solid beverage capable of reducing blood pressure comprises the following components: hawthorn, caulis spatholobi, selfheal, semen cassiae, uncaria, herba epimedii, ligusticum wallichii, sea-buckthorn, radix paeoniae alba and corn stigma. The preparation method comprises the following steps: mixing the components, mixing the mixture with water in a weight ratio of 1: (15-18), and then carrying out first continuous dynamic hot reflux extraction and concentration treatment under a first vacuum condition to obtain medicine residues and water extraction clear paste; mixing the medicine residues with an ethanol solution according to a weight ratio of 1: (11-13), and then carrying out second continuous dynamic hot reflux extraction and concentration treatment under a second vacuum condition to obtain an alcohol extraction filtrate; mixing and stirring the alcohol extraction filtrate and the water extraction clear paste, recovering ethanol under reduced pressure, and drying to obtain extract powder.
Owner:ZHIQIDAO (SHANXI) HEALTH CARE CO LTD

Special pillow device for side sleeping

The present invention discloses a special pillow device for assisting sleeping sideways; it comprises a main pillow body and a fixing part A for fixing the main pillow body; the main pillow body has a bottom surface suitable for abutting against a bed surface, a slope surface suitable for resting the back of a human body, and a side surface suitable for being fixed with the fixing part A; the fixing part A is detachably connected to one side of the bed edge so as to limit and fix the main pillow body to the bed surface. Beneficial effect: the main pillow body is fixed by the fixing part A so as not to slip and to facilitate the back of a snoring person to rest on the side, so as to reliably assist the snoring person to maintain side sleeping, thereby making the present invention highly reliable to use, and thus, the present invention has a good use effect.
Owner:PEKING UNIVERSITY SHENZHEN HOSPITAL

Application of compound wintercreeper mixture in preparation of medicine for treating aplastic anemia

The invention relates to the technical field of biological medicines, and discloses an application of a compound wintercreeper mixture in preparation of a medicine for treating aplastic anemia. Two aplastic anemia mouse models are created by irradiating compound cyclophosphamide and chloramphenicol and busulfan compound cyclophosphamide; it is proved that the compound wintercreeper mixture can reduce the death rate of mice with aplastic anemia, improve blood indexes of the mice with aplastic anemia and obviously recover the bone marrow hematopoietic function of the mice.
Owner:陕西含光生物科技有限公司

A compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.
Owner:AFFILIATED HOSPITAL OF ZUNYI UNIV

Roe polypeptide composition with immunity enhancing function, preparation method, application and preparation

The invention discloses a roe polypeptide composition with an immunity enhancing function, a preparation method, application and a preparation, and belongs to the technical field of bioactive polypeptides, the composition comprises at least one of polypeptides with the amino acid sequence being RWFPGKPLFWRA, FWKPLRGALFPW or KWRFPGALPWFA, the molecular weight is 1400-1550 Da, the preparation method comprises roe protein extraction, composite enzymolysis, ultrafiltration separation, chromatographic purification and solid-phase synthesis, and the roe polypeptide composition is prepared from the roe polypeptide composition with the immunity enhancing function. Animal experiments prove that the polypeptide can significantly enhance cellular immunity, humoral immunity, mononuclear-macrophage functions and NK cell activity, the mechanism relates to TLR2 / TLR4 receptor activation and NF-kB / MAPK signal pathways, and the polypeptide is good in safety and suitable for being developed into immunological enhancement health food or medicine.
Owner:WENZHOU MEDICAL UNIV

Traditional Chinese medicine composition for enhancing immunity and treating chicken virus infection and preparation method thereof

The invention belongs to the field of veterinary traditional Chinese medicines, and provides a traditional Chinese medicine composition for enhancing immunity and treating chicken virus infection and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 18 to 22 parts of radix isatidis, 18 to 22 parts of indigo naturalis, 15 to 20 parts of radix angelicae sinensis, 10 to 15 parts of poria cocos, 10 to 15 parts of rhizoma alismatis, 8 to 12 parts of medicated leaven, 8 to 12 parts of radix salviae miltiorrhizae, 8 to 12 parts of radix codonopsis, 8 to 12 parts of rhizoma cyperi and 4 to 8 parts of liquorice root. The traditional Chinese medicine composition disclosed by the invention has outstanding performance in the aspect of improving IgG and IgM levels, and further shows that the traditional Chinese medicine composition disclosed by the invention can effectively stimulate immune response of an organism and enhance the resistance of the organism to viruses. Animal pharmacological experiments show that the compound has a remarkable treatment effect on chicken infectious disease anemia, avian leukosis and chicken adenovirus infection, provides a new treatment thought for treatment of chicken viral infection, and has a wide application prospect.
Owner:SHANDONG VOCATIONAL ANIMAL SCI & VETERINARY COLLEGE

Application of catechin derivative WM-21 in preparation of neuroprotection and anti-neuroinflammation drugs

The invention discloses an application of a catechin derivative WM-21 in preparation of neuroprotection and anti-neuroinflammation drugs, and belongs to the technical field of biomedicines.The catechin derivative WM-21 is (2R, 3S)-2-(3, 4-dihydroxyphenyl)-6-((E)-styrene) chroane-3, 5, 7-triol (C22H19O6), and the chemical structural formula of the catechin derivative WM-21 is shown in the formula (I); the catechin derivative WM-21 provided by the invention has a neuroprotective effect on a plurality of nerve cells, has certain application potential in preparation of neuroprotective drugs, and is beneficial to prevention or alleviation of nervous system diseases. # imgabs0 #
Owner:SHENZHEN TECH UNIV

Antibiotic-free feed for marking prawns in artificial seawater and circulating water and preparation method of antibiotic-free feed

The invention provides an antibiotic-free feed for artificial seawater circulating water prawn roughing and a preparation method thereof, and relates to the technical field of seawater prawn feed preparation. The antibiotic-free feed is prepared by compounding spirulina powder, high gluten flour, krill powder, tenebrio molitor powder, clostridium ethanol protein powder, fish oil, a yeast extract, monopotassium phosphate, liquid phospholipid, mulberry leaf powder, mung bean powder, haematococcus pluvialis powder, selenium yeast and fish soluble. The compound feed overcomes the defects in the prior art, solves the problems that an existing compound feed is low in survival rate, poor in environmental change resistance and frequent in use of animal protection products in the shrimp seed thickening process, and comprehensively improves the culture economic benefits of the seawater prawns.
Owner:LECHANG JIAYA AGRI NEW TECH CO LTD

Preparation method of composition and decoction for treating hyperlipemia

The invention discloses a composition for treating hyperlipidemia and a preparation method thereof. The composition comprises striga asiatica extract; the extract is any one or more of rhizoma pinellinae praeparata, radix pseudostellariae, anoectochilus formosanus and mangnolia officinalis. The hyperlipemia is spleen deficiency and phlegm dampness type hyperlipemia, and the extract is decocted with water and extracted. The medicine comprises the following components in parts by mass: 10 parts of striga asiatica, 10 parts of rhizoma pinellinae praeparata and 5 parts of anoectochilus formosanus. 15 parts of radix pseudostellariae, 10 parts of rhizoma atractylodis and 10 parts of cortex magnoliae officinalis; , 10 parts of fried hawthorn, 15 parts of Poria cocos and 10 parts of Gorgon fruit. Mixing and crushing the composition, and putting the crushed composition into a decoction bag; soaking the decoction bag in 10 times of cold boiled water for set time TA; preparing liquid A is formed; heating the prepared liquid A and the decoction bag with strong fire until boiling; preparing liquid B is formed; decocting with slow fire to prepare liquid B and a medicine decocting bag, and setting time TB; preparing liquid C; and filtering to prepare liquid C to obtain filtrate A and decoction dregs A. The filtrate A is the decoction for treating hyperlipemia.
Owner:SHENZHEN BAOAN DISTRICT TRADITIONAL CHINESE MEDICINE HOSPITAL

Popular searches