22results about How to "Enhance immune function" patented technology

The present invention relates to a composition of aliphatic emulsion preparation for malignant thoracicoabdominal hydrops and its preparation method. It is made up by adopting pure natural anticancer medicine elemene and at least one polysaccharide selected from ginseng polysaccharide, astragalus polysaccharide, acanthopanax polysaccharide and lyceum polysaccharide as raw material. Said invention can obviously raise solubility of medicine, increase stability of medicine, effectively remove and kill cancer cells and raise immunity of body.

The application provides a momordica root polysaccharide and a preparation method and application thereof, and belongs to the technical field of natural product development. The preparation method of the momordica root polysaccharide comprises the following steps: drying and crushing momordica roots, and removing fat by ethanol reflux; after water extraction and alcohol precipitation, and removing protein, a momordica root crude polysaccharide is obtained; and the momordica root crude polysaccharide is sequentially separated and purified by DEAE-52 cellulose column and Sephadex LH20 gel column to obtain the momordica root refined polysaccharide. The preparation method has the advantages that the polysaccharide obtained by directly extracting water in the prior art has a narrow molecular weight distribution range and better immune enhancement activity. Experimental results show that the momordica root polysaccharide can stimulate RAW264.7 cells to secrete NO, TNF-alpha and IL-6 factors, enhance the phagocytosis of RAW264.7 cells, and thus enhance the cell immune function, and can be applied to the development of products for improving immunity.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The invention discloses a roe polypeptide composition with an immunity enhancing function, a preparation method, application and a preparation, and belongs to the technical field of bioactive polypeptides, the composition comprises at least one of polypeptides with the amino acid sequence being RWFPGKPLFWRA, FWKPLRGALFPW or KWRFPGALPWFA, the molecular weight is 1400-1550 Da, the preparation method comprises roe protein extraction, composite enzymolysis, ultrafiltration separation, chromatographic purification and solid-phase synthesis, and the roe polypeptide composition is prepared from the roe polypeptide composition with the immunity enhancing function. Animal experiments prove that the polypeptide can significantly enhance cellular immunity, humoral immunity, mononuclear-macrophage functions and NK cell activity, the mechanism relates to TLR2 / TLR4 receptor activation and NF-kB / MAPK signal pathways, and the polypeptide is good in safety and suitable for being developed into immunological enhancement health food or medicine.

The invention belongs to the field of feed additives, and particularly relates to a nano feed additive for improving intestinal flora and a preparation method thereof.The preparation method comprises the following steps that (1) an electric arc furnace with pure copper as an anode and a graphite rod as a cathode is provided, absolute ethyl alcohol is injected into the furnace body in the vacuum state in the electric arc furnace, the arc starting current is controlled to be 40-60 A, and the temperature is controlled to be 20-30 DEG C; and purifying in an argon atmosphere for 12-48 hours to obtain the Cu-coated C nano-particles. And (2) carrying out oxidation reaction on the Cu-coated C nano-particles in an oxygen-containing atmosphere at the reaction temperature of 200-350 DEG C for 1-5 hours to obtain an oxidized product, namely the nano feed additive. The nano feed additive disclosed by the invention can be used for preventing and treating bacterial infection, enhancing the immune function and the anti-oxidative stress function of an organism, improving intestinal flora and prolonging the service life of animals, is an effective and safe functional feed additive, is simple in preparation method and low in production cost, can realize large-scale preparation, and has an important application prospect.

The application provides a camellia plant endophytic bacteria, a bacterial agent thereof and an anti-influenza virus A application; the camellia plant endophytic bacteria is Bacillus thuringiensis, which is preserved in the China General Microbiological Culture Collection Center with a preservation number of CGMCC No.32945. The fermentation product of the strain shows good antiviral activity in in vitro and in vivo experiments, can effectively inhibit the replication of influenza virus, and protect infected mice from lethal influenza virus; also shows the effect of regulating immune response, enhances the secretion of IFN-gamma by down-regulating the secretion of pro-inflammatory factors such as IL-6 and IL-10, thereby improving the immune resistance of the body.

The invention relates to the technical field of microorganisms, and particularly discloses lactobacillus delbrueckii subsp. Bulgaricus KFSY10 and application thereof in the aspect of improving the immune function, the lactobacillus delbrueckii subsp. Bulgaricus KFSY10 is preserved in the China General Microbiological Culture Collection Center on May 2, 2018, the preservation address is CGMCC (China General Microbiological Culture Collection Center), and the preservation number is CGMCC NO. The Lactobacillus delbrueckii subsp. Bulgaricus is located in Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, West Beichen Road, Chaoyang District, Beijing, has a preservation number of CGMCCNO: 15717, and is classified and named as Lactobacillus delbrueckii subsp. Bulgaricus KFSY10. The lactobacillus delbrueckii subsp. Bulgaricus KSFY10 provided by the invention can be used for directly improving the immune function of an immunosuppressive mouse by protecting and maintaining normal physiological structures of central and peripheral immune organs and promoting secretion of serum cytokines and immune globulins; and the immunologic function of the mouse can be indirectly promoted by regulating and controlling acute and chronic inflammatory reactions of intestinal tracts, so that side effects and adverse reactions caused by the use of chemical drugs are effectively avoided.

This invention discloses a pharmaceutical composition, its formulation, and its application for treating rheumatic arthralgia. The pharmaceutical composition comprises the following components in parts by weight: 20-40 parts of Salvia miltiorrhiza, 10-20 parts of Paeonia lactiflora, 20-40 parts of Panax notoginseng rootlets, 10-20 parts of Ligusticum chuanxiong, 9-20 parts of Angelica sinensis, 9-20 parts of Clematis chinensis, 9-20 parts of Angelica pubescens, 9-20 parts of Chaenomeles speciosa, 9-20 parts of Saposhnikovia divaricata, 9-20 parts of Achyranthes bidentata (processed with wine), and 9-20 parts of Carthamus tinctorius. Pharmaceutically acceptable excipients may be added to the pharmaceutical composition to prepare a formulation. The pharmaceutical composition and its formulation can be used to treat rheumatic arthralgia.

The application discloses a plant extract for improving the immune function of senescent dendritic cells and application thereof. The application belongs to the technical field of biotechnology and particularly relates to a plant extract for improving the immune function of senescent dendritic cells and application thereof. The artemisia extract can be applied in the following aspects: application in improving the immune function of senescent dendritic cells, application in improving the immune aging of a body, application in preparing a product for improving the immune function of senescent dendritic cells, and application in preparing a product for improving the immune aging of a body. It is found that the active ingredient apigenin of the artemisia extract has the characteristics of bidirectional regulation of the function of senescent dendritic cells, that is, the expression of the costimulatory molecule CD86 gene which is down-regulated due to aging can be improved, and the level of the inflammatory factor IL-12 which is increased due to cell aging can be reduced. The artemisia is a plant with the same medicinal and edible functions, has low safety risks, and has application value.

The lung cancer ointment is prepared from the following raw materials in parts by weight: 15 parts of ginseng slices, 20 parts of lucid ganoderma, 60 parts of pumice stone, 15 parts of fried semen lepidii, 30 parts of Chinese dates, 10 parts of fructus amomi rotundus, 15 parts of rhizoma pinelliae preparata, 30 parts of rhizoma atractylodis macrocephalae, 30 parts of poria cocos, 20 parts of pericarpium citri reticulatae, 60 parts of semen coicis, 10 parts of curcuma zedoary, 15 parts of radix clematidis, 15 parts of rhizoma sparganii, 15 parts of radix scrophulariae, 15 parts of taxus chinensis and 15 parts of thunberg fritillary bulb. The lung cancer ointment formula capable of tonifying spleen, eliminating phlegm and detoxifying can improve the immune function of a patient with lung cancer due to spleen deficiency and regulate PD-1 / PD-L1 pathways of a mouse with lung cancer, and bioinformatics analysis finds that LncRNA ERVH48-1 is expected to become a new biological target of a lung adenocarcinoma immune microenvironment, and a new thought and a new method can be provided for clinically applying traditional Chinese medicines to treat lung cancer.

This invention relates to a composition for improving intestinal barrier damage and its application. The composition comprises three or more of 2'-FL, LNT, 3'-SL, and zinc gluconate, wherein zinc gluconate is included in the composition. The composition provided by this invention can safely and effectively improve intestinal barrier damage.

The invention provides a compound probiotic composition and application thereof in a product for improving intestinal health, the compound probiotic composition is prepared from lactobacillus rhamnosus GG, lactic acid bacteria compound powder, plant lactobacillus GOLDGUT-LP1024 and lactobacillus paracasei GOLDGUT-LC12345, and the lactobacillus rhamnosus GG, the lactic acid bacteria compound powder, the plant lactobacillus GOLDGUT-LC12345 and the lactobacillus paracasei GOLDGUT-LC12345 are added into the compound probiotic composition. The lactic acid bacteria compound powder is prepared by mixing bifidobacterium longum subsp. Longum BORI, lactobacillus acidophilus AD031, bifidobacterium bifidum BGN4, bifidobacterium animalis subsp. Lactis AD011 and bifidobacterium longum subsp. Infantis IBS007; the plant lactobacillus GOLDGUT-LP1024 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the plant lactobacillus GOLDGUT-LP1024 is CGMCC No.28801. The compound probiotic composition provided by the invention can improve the immune function and metabolism function of the intestinal tract so as to improve the health of the intestinal tract and relieve antibiotic-related diarrhea.

The application discloses an egg white protein source peptide with the function of improving immunocompromise and application thereof, and belongs to the technical field of small molecule peptides. The egg white protein is subjected to enzymolysis by using a protease, and an albumin peptide is prepared by intercepting an enzymolysis product with a molecular weight less than 1000 Da, wherein the albumin peptide contains a tetrapeptide MSPF with the function of improving immunocompromise. Animal model function verification shows that the tetrapeptide MSPF and the albumin peptide containing the peptide segment can significantly improve immunocompromise, the number of macrophages is increased by 62.94%, the number of neutrophils is increased by 62.69%, and the content of interferon gamma is increased by 76.11%, thereby enhancing the immunity of the organism. The food-derived bioactive peptide has high biological safety. Therefore, the tetrapeptide MSPF or the albumin peptide containing the peptide segment can be applied to the preparation of medicines for improving immunocompromise or health care food for enhancing immunity, and has good market prospect and application potential.

The invention relates to the technical field of medical treatment and public health, and discloses a decoction and a hot compress bag for dredging treatment of a whole-body clogging point, and a corresponding pushing and pressing technology. The decoction is composed of the following raw materials by weight: 40 g of dried ginger slices, 3 g of licorice, 3 g of red dates, 3 g of Chinese wolfberry, 5 g of ginseng, and 2.5 L of water. The hot compress bag comprises a bag body and a traditional Chinese medicine bag placed in the bag body, and the bag body is filled with ores and / or red beans. According to the decoction and the hot compress bag for dredging treatment of the whole body clogging point, the decoction for oral administration and the hot compress bag for external application are combined with corresponding pushing and pressing methods for combined use, various diseases caused by clogging of organs and tissues of a patient can be effectively treated, and three highs (hyperlipidemia, hyperglycemia and hypertension), leukemia, rheumatoid arthritis and lupus erythematosus can be effectively improved and cured; , hyperthyroidism, hypothyroidism, andrology and gynecology diseases. The traditional Chinese medicine composition has the advantages of obvious effect, high cure rate, rapid improvement of immune function of patients, improvement of disease resistance, safety, effectiveness and no toxic or side effect.

A compound feed additive for improving egg quality, its preparation method, and its application are disclosed. The raw materials of the compound feed additive are composed of the following by weight percentage: 65-75% three-stage temperature-controlled fermented mulberry leaf powder, 8-12% compound probiotic microcapsule preparation, and 15-25% functional carrier. 5-8% of the compound feed additive prepared according to this invention is added to the basal diet of laying hens and fed continuously for 42-56 days. The three-stage temperature-controlled fermentation of this invention reduces the tannin content in mulberry leaves from 7.2 mg / g to below 4.7 mg / g, with a degradation rate ≥30%. The low tannin content improves feed palatability and effectively solves the problem of decreased feed intake caused by high-dose mulberry leaf addition.

The application discloses a kind of preparation methods of degradable seedling to with enhanced vegetable immune function, comprising the following steps: step one, preparation seedling raw material;Step two, preparation polypyrrole-polycaprolactone complex;Step three, the seedling raw material is made into seedling outer layer, the inside of the seedling outer layer is set by the polypyrrole-polycaprolactone complex made seedling inner layer, and connect micro bio-battery, and the inside of the seedling inner layer is set multiple by the polypyrrole-polycaprolactone complex made conductive circuit, finally the degradable seedling to with enhanced vegetable immune function is obtained.The biodegradable conductive polymer is introduced, biological electric stimulation is provided for vegetable root system, vegetable growth and development are promoted, and vegetable immune function is enhanced.

The invention relates to the technical field of feed additives, in particular to a rhizoma atractylodis macrocephalae polysaccharide extract, a preparation method of the rhizoma atractylodis macrocephalae polysaccharide extract, a compound feed additive for piglets and a feed for the piglets. The preparation method of the atractylodes macrocephala polysaccharide extract comprises the following steps: sequentially carrying out reflux degreasing, ultrasonic treatment and compound enzyme enzymolysis treatment on atractylodes macrocephala rhizomes. According to the method, fat-soluble components can be removed in advance, and a basis is provided for extraction and purification of polysaccharide components; then, cell wall structures are destroyed through ultrasonic treatment, so that more contact areas exist between the materials and the solvent, more enzymolysis sites are exposed, and more polysaccharide components are released. Furthermore, the atractylodes macrocephala koidz polysaccharide obtained by the method has relatively high active ingredients, and is in synergistic compatibility with components such as pachymaran and ellagic acid, so that the immunity of the piglets is improved, and the diarrhea rate is reduced.

This invention belongs to the field of food fermentation and functional beverage technology, specifically relating to a strain of *Lactobacillus fermentans* and its application in the preparation of fermented goji berry juice that enhances immunity. The *Lactobacillus fermentans* strain LFY21 was deposited on November 17, 2025, at the China Center for Type Culture Collection (CCTCC), with accession number CCTCC NO: M 20252569; the deposit address is Wuhan University. This strain grows vigorously in goji berry juice, but exhibits weak acid production during fermentation, resulting in a high sugar-acid ratio, good flavor and palatability, and high free radical scavenging activity and total phenol content. Furthermore, animal experiments have demonstrated that fermented goji berry juice prepared with this strain can effectively enhance immune function, showing potential as an immune enhancer.

This invention relates to the field of pet food technology, specifically to a nutritional supplement pill for parrots, its preparation method, and its application. The nutritional supplement pill is composed of basic ingredients and functional ingredients. The basic ingredients include buckwheat kernels, barley kernels, black beans, red beans, soybeans, black rice, mung beans, red peanuts, Job's tears, black sesame seeds, oat kernels, corn, egg yolks, dried bananas, dried hawthorn berries, dried coconut, raisins, goji berries, purple sweet potatoes, sunflower seeds, walnuts, chili peppers, chickpeas, mealworms, flax seeds, dried dates, pumpkin seeds, and carrots. The functional ingredients include small peptides, vitamin C, brewer's yeast, sodium dehydroacetate, calcium lactate, methionine, lysine, and honey. The total weight percentage of the basic ingredients and functional ingredients is 100%. This nutritional supplement pill, through scientific formulation, closely matches the physiological needs of parrots, exhibiting excellent palatability and digestibility, thus comprehensively meeting the daily growth and health maintenance needs of parrots.

This invention relates to the application of microalgae polysaccharides in enhancing intestinal immunity in dairy cows, belonging to the field of feed technology. The microalgae polysaccharides prepared by this invention are used to increase the secretion of IgA, IgG, and IgM by the intestinal mucosa. This invention uses a specific ratio of kelp buds, Dunaliella salina, and Haematococcus pluvialis for pre-enzymatic hydrolysis using trypsin and nattokinase for a certain period of time, followed by enzymatic hydrolysis using hemicellulase and pectinase for a certain period of time. The resulting microalgae polysaccharide product has excellent effects in promoting the secretion of immunoglobulins in the dairy cow intestine, significantly increasing the content of IgA, IgG, and IgM in the dairy cow intestine, thereby enhancing intestinal immunity. It can serve as a highly effective alternative component for improving the intestinal immune function of dairy cows.

The invention provides methods and compositions for treating locally advanced or metastatic breast cancer and for enhancing immune function in an individual having locally advanced or metastatic breast cancer. The methods comprise administering a PD-1 axis binding antagonist and a taxane.

This invention discloses the use of miR-181a-5p as a biomarker or therapeutic target in the diagnosis and treatment of sepsis. Studies have found that the expression level of miR-181a-5p changes during the hyperimmune and immunosuppressive phases of sepsis. Analysis of blood samples from two sepsis patients (Patient 1 and Patient 2) at different time points after admission revealed a negative correlation between miR-181a-5p expression and the severity of the disease, assessed using the Sepsis-Associated Organ Failure (SOFA) score. Further in vitro experiments showed that overexpression of miR-181a-5p in mouse primary dendritic cells (DCs) can enhance the immune function of DCs by targeting TNF-α mRNA. The miR-181a-5p mimic provided by this invention can promote miR-181a-5p expression, enhance DC function, and thus effectively improve the immune function of sepsis patients.