The invention provides healthcare wine capable of prolonging life and a preparation process thereof. The preparation process comprises the following steps: enabling raspberry, peony, black bean, cing cian, rehmanniae vaporata, epimedium, licorice, cynomorium, tuber of multiflower knotweed, divaricate saposhnikovia root, north medlar, radix polygonati officinalis, astragalus, tuckahoe, cuscuta, ligustrum lucidum, eucommia, aspartic, cinnamon, rhizoma anemarrhenae, root of straight ladybell, ligusticum wallichii, ophiopogon japonicus, achyranthis bidentatae, morinda officinalis, schisandra, mulberry, and curculigo to circulate steam to be soaked in white wine for some time, adding crystal sugar into the mixture, soaking for 30 days, taking out the medicated wine to be added with rosa laevigata, red dates, hematoxylin and cloves, and then soaking for some days to prepare the healthcare wine. The invention is based on the wine for prolonging life, is an improvement meeting the requirements of the markets on color, smell and taste and the like for mainly aiming at the characteristics of similar bands of healthcare wine markets, has the effects of reconciling yin and yang, dispelling wind and dampness, nourishing the body, building the body and beautifying the features, defering senility and the like. The medicated wine is red and transparent, has strong fragrance, 42 degrees of finished wine, good taste and the like.