2results about How to "Restore motor function" patented technology

The application provides a nano drug delivery system based on a Gap19 polypeptide. The system is prepared by mixing DSPE-PEG2k-Gap19 and ROS response material DSPE-TK-PEG5k-MPC to form nanoparticles, has a double-layer structure, and can enhance the stability and blood-spinal cord barrier penetration capacity of Gap19. The ROS response characteristics can realize damage microenvironment triggered drug release, simultaneously remove active oxygen and inhibit Cx43 hemichannel activity, and synergistically promote nerve repair. Experiments show that the system has good biocompatibility, targeted aggregation and functional recovery effect, and provides a new material and strategy for spinal cord injury treatment.

The present application relates to nerve growth factor inducible protein or its gene in the preparation of treating spinal cord injury drug application. The present application proves that the lentivirus of overexpressing nerve growth factor inducible protein gene can promote the regeneration of oligodendrocytes, and then can effectively improve the recovery of motor function of spinal cord injury animal model through cell experiment and animal experiment.