5results about How to "Restore motor function" patented technology

The utility model discloses a multifunctional venous circulation improving device which comprises an MCU module, a key module and a waveform control module. The MCU module is electrically connected with the key module and the waveform control module and used for detecting key signals of the key module and controlling specified waveforms output by the waveform control module according to the key signals so as to simulate corresponding treatment techniques to treat the lower limbs. The prescribed waveform includes at least a first waveform. The waveform control module outputs the first waveform with specified parameters, the first waveform can be effectively used for preventing or delaying disuse atrophy, enhancing muscle performance, retraining muscles and recovering muscle movement functions, the three waveforms are alternately used, the treatment effect can be improved, the protection unit is arranged on the waveform control module, and after output or work is stopped, the waveform control module can be protected from being damaged. The residual voltage in electronic elements of the boosting unit and the output unit is quickly released, so that the experience of a patient is improved and the service life of the electronic elements is prolonged.

The application provides a nano drug delivery system based on a Gap19 polypeptide. The system is prepared by mixing DSPE-PEG2k-Gap19 and ROS response material DSPE-TK-PEG5k-MPC to form nanoparticles, has a double-layer structure, and can enhance the stability and blood-spinal cord barrier penetration capacity of Gap19. The ROS response characteristics can realize damage microenvironment triggered drug release, simultaneously remove active oxygen and inhibit Cx43 hemichannel activity, and synergistically promote nerve repair. Experiments show that the system has good biocompatibility, targeted aggregation and functional recovery effect, and provides a new material and strategy for spinal cord injury treatment.

The present application relates to nerve growth factor inducible protein or its gene in the preparation of treating spinal cord injury drug application. The present application proves that the lentivirus of overexpressing nerve growth factor inducible protein gene can promote the regeneration of oligodendrocytes, and then can effectively improve the recovery of motor function of spinal cord injury animal model through cell experiment and animal experiment.

The invention discloses a polypeptide for repairing nerve injury and a preparation method and application thereof, and the preparation method of the polypeptide comprises the following steps: S1, swelling resin for synthesis, removing an Fmoc protecting group, and cleaning to obtain resin to be grafted; s2, mixing amino acid to be grafted, a coupling agent and an alkali solution to obtain a mixed reactant, completely immersing resin to be grafted in the mixed reactant, and reacting for a period of time under the protection of inert gas; s3, sequentially replacing the amino acids to be grafted in the step S2 according to a TKDGKQAAW sequence, so that the resin to be grafted is sequentially grafted into the specified amino acids to prepare a crude product; and S4, separating the polypeptide from the resin in the crude product by using a shearing liquid, purifying the polypeptide by using a high performance liquid chromatograph, identifying the target polypeptide by using a mass spectrometer, collecting the target polypeptide, and freeze-drying to obtain the polypeptide.

The invention relates to the technical field of functional foods, and particularly discloses a dietary therapy composition for promoting functional recovery after spinal cord injury and relieving neuroinflammation as well as a preparation method and application of the dietary therapy composition. The preparation method of the dietary therapy composition comprises the following steps: dissolving corn protein in an ethanol solution, adding a sodium deoxycholate solution, stirring and mixing to obtain a mixed solution, adding indole-3-propionic acid, stirring until ethanol is evaporated, putting into a dialysis bag, adding a PBS buffer solution, stirring to remove free indole-3-propionic acid, and freeze-drying to obtain corn protein-IPA nanoparticles; the preparation method comprises the following steps: adding ultrapure water into pectin, mixing and stirring, adding the corn protein-IPA nanoparticles, continuously stirring uniformly, and freeze-drying to obtain pectin-corn protein-IPA nanoparticles, namely the required dietary therapy composition. The dietary therapy composition prepared by the invention can promote the recovery of motor functions after spinal cord injury, inhibit the activation of oxidative stress, relieve neuroinflammation and promote axon regeneration.