465 results about "Compounded preparations" patented technology

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a peach kernel and safflower four-ingredient decoction compound preparation and a preparation method and a quality control method thereof. The invention provides a preparation method of a peach kernel and safflower four-component decoction compound preparation by screening and optimizing an enrichment method of volatile oil in extraction, concentration, inclusion and drying processes on the basis of an ancient water decoction process. According to the peach kernel and safflower four-drug decoction compound preparation prepared by the invention, the quality consistency with a reference sample is realized, including the consistency of each content index in the compound preparation with the reference sample and the consistency of a fingerprint spectrum with the reference sample; especially, characteristic peaks of volatile components-ligustilide, senkyunolide I and senkyunolide A are presented in the fingerprint spectrum, and the consistency of the content of the volatile oil is determined. Moreover, the quality control method provided by the invention is expected to be used for quality control of industrial large-scale production of a classic famous prescription, namely the peach kernel and safflower four-ingredient decoction compound preparation, and has a good application prospect.

The invention discloses a gradient alcohol extraction preparation method of compound honeysuckle flower drops for improving T cell activity, and relates to the technical field of traditional Chinese medicine compound preparations, honeysuckle flower and radix astragali are selected for pretreatment, an ethanol aqueous solution and an interaction regulating agent are added for infiltration, an online traditional Chinese medicine compound preparation HPLC is adopted for dynamic alcohol concentration adjustment and temperature extraction under monitoring of the traditional Chinese medicine compound preparation, the method disclosed by the invention has the advantages that the interaction regulating agent is added in the raw material infiltration stage to block bad interaction among active components, and the online monitoring system is utilized to dynamically adapt the ethanol concentration and the extraction temperature to realize step-by-step efficient dissolution of the multi-polar components; the antioxidant is matched to inhibit oxidation of thermosensitive components, and the solubilizer assists dissolution of insoluble components, so that the core defect that synergistic extraction of multi-polar active components, degradation of the thermosensitive components and interaction inhibition of the components in the compound honeysuckle flowers cannot be considered in the prior art is overcome, and loss or antagonism of the active components is effectively avoided.

The invention relates to the technical field of traditional Chinese medicine formulas for treating hypertension, in particular to a traditional Chinese medicine compound preparation for treating liver-yang hyperactivity type hypertension or yin deficiency and yang hyperactivity type hypertension as well as a preparation method and application of the traditional Chinese medicine compound preparation for treating liver-yang hyperactivity type hypertension or yin deficiency and yang hyperactivity type hypertension. The medicinal materials comprise gastrodia elata, uncaria, fried stiff silkworm, cornu bubali, concha haliotidis, selfheal, radix cyathulae, salted eucommia ulmoides, salted semen plantaginis and fried spina date seed. The preparation method comprises the following steps: decocting a required amount of buffalo horn with water to obtain a buffalo horn decoction; soaking other medicinal materials except the uncaria in water, decocting the soaked medicinal materials and the cornu bubali decoction for two to three times, adding the uncaria into the decoction five to seven minutes before the last decoction, and combining the decoction to obtain the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation disclosed by the invention has a blood pressure lowering effect on people with different symptoms of hypertension, is stable in blood pressure lowering and reliable in effect, and has the effects of nourishing yin, suppressing yang, calming the liver and calming the heart.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound preparation for preventing and treating sepsis based on intestinal treatment and gasification regulation and a preparation method and application of the traditional Chinese medicine compound preparation. The composition is prepared from the following medicinal materials in parts by weight: 3 to 10 parts of rheum officinale, 5 to 10 parts of fructus aurantii, 5 to 10 parts of radix aucklandiae, 10 to 15 parts of fructus gardeniae, 10 to 15 parts of dandelion, 10 to 15 parts of fructus forsythiae, 10 to 15 parts of herba artemisiae scopariae, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of radix paeoniae rubra, 10 to 15 parts of radix salviae miltiorrhizae, 15 to 20 parts of astragalus membranaceus, 10 to 15 parts of rhizoma anemarrhenae, 10 to 15 parts of fructus cannabis, 10 to 15 parts of semen pruni and 3 to 6 parts of raw liquorice. The traditional Chinese medicine compound provided by the invention considers the treatment rules of relaxing bowels, purging heat, promoting qi circulation, removing stagnation, detoxifying, dispersing blood stasis, reinforcing qi, nourishing yin and the like, and also considers the effects of relaxing bowels, regulating qi and supporting healthy qi, various diseases of sepsis patients can be remarkably improved through the synergistic effect of the medicines in the formula, and the traditional Chinese medicine compound especially has an obvious curative effect on gastrointestinal dysfunction. A novel traditional Chinese medicine treatment thought is provided for clinical treatment of sepsis diseases.

The invention discloses a preparation method of 20 (E)-ginsenoside F4 and application of the 20 (E)-ginsenoside F4 in preparation of anti-liver injury medicines, and relates to the technical field of biological medicines. The rare ginsenoside 20 (E)-ginsenoside F4 is prepared and purified from ginsenoside Re through an acid catalytic conversion method, and the rare ginsenoside 20 (E)-ginsenoside F4 shows remarkable advantages and wide prospects in research and development of liver protection drugs. The monomer has strong liver protection activity, complies with the development trend of monomeric compound preparations, and provides efficient active ingredients for liver protection drugs. The 20 (E)-ginsenoside F4 with efficient activity, excellent safety and environment-friendly preparation characteristics can be widely applied to preparation of liver protection drugs or pharmaceutical compositions, especially drugs or pharmaceutical compositions for treating liver injury caused by chemotherapeutic drugs.

The application provides a Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application, and relates to the technical field of animal medicine. The Chinese medicine compound preparation is composed of 10 Chinese medicines, i.e. honeysuckle, forsythia, inula flower, platycodon grandiflorum, euphorbia helioscopia, xiaochangqing, fresh eucalyptus globulus, fried stemona, cat's claw and augustifolia, follows the principle of Chinese medicine syndrome differentiation and treatment, is reasonably matched, and the medicines are coordinated with each other to increase the efficacy. The Chinese medicine compound preparation can significantly reduce the levels of TNF-alpha and IL-6 in serum, increase the level of IFN-gamma, obviously alleviate the clinical symptoms of livestock and poultry respiratory tract infection, reduce the mortality, has a good treatment effect on the related diseases of livestock and poultry respiratory tract infection, can improve the drug resistance of antibiotic drugs, reduce the drug residues of chemical agents in livestock and poultry, and guarantees the health of livestock and poultry and the safety of animal source food.

The method comprises the following steps: dissolving lipoic acid and a drug in an organic solvent to form a homogeneous solution, dropwise adding deionized water while stirring, then adding a reducing agent, initiating lipoic acid polymerization and drug co-assembly in situ at 20-40 DEG C to form a drug-loaded micelle solution, and carrying out freeze drying on the drug-loaded micelle solution to obtain the nano-preparation drug based on polylipoic acid. And dialyzing and purifying to obtain the nano preparation medicine based on polylipoic acid. The preparation method is characterized in that lipoic acid has dual characteristics of a drug carrier matrix and a dynamic crosslinking monomer, carrier synthesis and efficient drug encapsulation are synchronously realized through one-step in-situ polymerization-co-assembly, and the technical bottleneck that a traditional nano-carrier needs pre-synthesis and step-by-step drug loading is broken through. The method has the following practicability: (1) the process is simple and efficient, complex equipment is not needed, and reaction conditions are mild; (2) the drug loading performance is excellent, and the particle size is uniform and adjustable (50-300 nanometers); (3) a polylipoic acid skeleton endows the nano-drug preparation with environmental responsiveness, and intelligent drug release can be realized; and (4) the method is suitable for hydrophobic drugs and compound preparations. The method provides a high-load, high-stability and stimuli-responsive nanocrystallization solution for hydrophobic drug delivery, and has application value in the field of nano-medicines.

The invention relates to the technical field of traditional Chinese medicine detection, in particular to a quality control method of a heart fire clearing lotus seed beverage compound preparation, which comprises the following steps: respectively preparing test solution A-E; based on the test solution A, identifying the scutellaria baicalensis by adopting a thin-layer chromatography; identifying cortex lycii radicis and liquorice based on the test solution B, identifying ginseng based on the test solution C, identifying semen plantaginis based on the test solution D, and identifying lotus seeds based on the test solution E. According to the method, repeated extraction of the reference sample during identification of different medicine flavors can be reduced, and the method has the advantages of clear spots, good separation degree, strong specificity, no background interference and good durability.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a kidney-tonifying and liver-nourishing compound preparation and a preparation method thereof. The compound preparation comprises 5-15 parts of roasted herba epimedii, 5-15 parts of fructus cnidii, 50-70 parts of roasted radix astragali and 10-30 parts of pulp of dogwood fruit. The traditional Chinese medicine composition has remarkable curative effects on various diseases and chronic strain caused by deficiency of liver and kidney and deficiency of blood and essence, such as dizziness, blurred vision, fatigue, swelling and pain of waist, back and limbs, dry mouth and eyes, limb ache and weakness, irregular menstruation, incapability of holding weight or hemiplegia and the like, and has a very good application prospect.

The invention discloses a traditional Chinese medicine composition for treating infantile traumatic swelling and pain. The traditional Chinese medicine composition comprises the following raw material medicines: radix rehmanniae recen, radix paeoniae rubra, angelica sinensis, ligusticum wallichii, herba lycopi, pericarpium citri reticulatae viride, poria with hostwood, liquorice, Chinese starjasmine stem, fried malt and fried endothelium corneum gigeriae galli. The invention also provides a traditional Chinese medicine compound preparation and application thereof in preparation of a medicine for treating infantile traumatic swelling and pain. The composition disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, relieving swelling and pain and promoting swelling fading, is high in effective rate and capable of accelerating the process of rehabilitation treatment or subsequent operative treatment, and has relatively high clinical value.

The present application relates to the field of biological glass, in particular to a kind of composite biological glass and its preparation method and application.The present application uses rhBMP-2, doped antibacterial ion 45S5 bioactive glass and polyethylene glycol-lactide-glycolide polymer compound preparation slow-release antibacterial biological glass, the rhBMP-2 can occur synergistic effect with doped antibacterial ion 45S5 bioactive glass, compared with homologous growth factor can play more optimal synergy with antibacterial ion, so as to have higher antibacterial property and osteogenesis, while having longer slow-release effect in polyethylene glycol-lactide-glycolide polymer.The composite biological glass provided by the present application overcomes the pain points of the prior art for the treatment of oral bone defect, improves the treatment effect, reduces the amount of antibiotic use, and reduces the risk of infection.

A kit (100) and method (200) are provided for administering an active ingredient (112) to a subject to elicit a response. The kit comprises a first container (110) with an active ingredient (112) and a second container (120) with an adjuvant (122). The containers permit the ingredients to be admixed to form a compounded preparation for delivery into the subject's tissue. The active ingredient can comprise an allergen. The kit can also include temperature control and mixing components, potentially involving a third container (130). The method comprises providing the kit (100), admixing the ingredients, and injecting the compounded form into the subject's tissue such as a lymph node. The injection can be monitored and repeated. The approach can elicit various responses such as desensitization according to the type of active ingredient used. Overall, the kit (100) and method (200) provide targeted delivery of active ingredients to efficiently provoke a localized response in the subject.

The invention belongs to the technical field of traditional Chinese medicines, and provides a badger fat compound external preparation for treating radioactive skin injury. According to the traditional Chinese medicine differentiation of radioactive skin injury, the compound preparation is prepared by selecting a method of clearing away heat and toxic materials, eliminating dampness, promoting blood circulation, removing blood stasis, removing slough, promoting granulation, cooling blood and nourishing yin, and comprises the following main components: raw rhubarb, lithospermum, sanguisorba officinalis, aloe, folium isatidis, cottonrose hibiscus leaves, dandelion, badger fat and borneol. The compound preparation is prepared from Chinese herbal medicines and badger fat according to unique pathological characteristics of radioactive skin injury, and has a better treatment effect on radioactive skin injury, especially moderate and severe injury.

The invention provides a compound preparation containing curcumin nano-particles as well as a preparation method and application of the compound preparation. Curcumin is wrapped by alcohol-soluble protein to form nano-particles, and the nano-particles are used as a Pickering milk solid emulsifier for emulsifying and dispersing vitamin D and olive oil into an oil phase to form a stable droplet structure; furthermore, polysaccharide with enteric characteristics is used as a water-phase carrier material, and the emulsion is encapsulated in the pellet by using a hole sharpening-solidification method, so that the solidification of the liquid medicine (the emulsion) is realized; the three natural components, namely the curcumin, the vitamin D and the olive oil, are ingeniously integrated into a whole; the targeting property of the medicine at the colon part is improved; meanwhile, the destructive effect of the gastrointestinal tract environment on the medicine carrying nanoparticles is reduced.

The invention belongs to the technical field of medicine manufacturing, and particularly relates to a compound preparation containing faropenem sodium as well as a preparation method and application of the compound preparation. According to the invention, the production prescription is optimized, the stability of the medicine can be effectively improved, the unpleasant smell of the medicine is covered, and the medication compliance of children is obviously improved. The epigallocatechin-aluminum complex can serve as a free radical scavenger in a preparation system, oxygen free radicals are effectively captured and neutralized, and the influence of oxidative stress on the medicine is reduced; moreover, the existence of aluminum ions not only enhances the stability of EGCG, but also reduces the drug degradation reaction under the catalysis of the ions through chelation with trace metal ions (such as iron, copper and the like) in the preparation. In addition, aluminum ions can also directly form a stable complex with faropenem sodium, so that the chemical stability of the faropenem sodium is further improved.

This invention discloses a quality control method for an anti-snoring oral liquid and its application, belonging to the field of traditional Chinese medicine quality testing technology. The method includes thin-layer chromatography identification of Gleditsia sinensis thorns, Scrophularia ningpoensis, and Glycyrrhiza uralensis, as well as high-performance liquid chromatography (HPLC) determination of hesperidin content. By optimizing pretreatment, developing solvent, and colorimetric conditions, this invention achieves efficient and specific identification and quantification of multiple components in the compound preparation. The method is highly specific, produces clear spots, has good separation, and is tolerant to a wide temperature and humidity range (2-40℃, 20%-75%RH), requiring no strict environmental control, significantly improving detection efficiency and providing a reliable basis for establishing quality standards for this preparation.

The invention discloses a compound preparation for treating alopecia and a preparation method and application thereof, and belongs to the technical field of biological medicine. The compound preparation prepared from the hair follicle stem cells, the hair follicle stem cell exosome and the traditional Chinese medicine preparation is used for treating the alopecia in various administration modes such as internal administration, external administration and injection. The compound preparation and the application thereof can be used for remarkably improving the alopecia; compared with a traditional medicine, the compound preparation has no side effect and can improve the scalp environment from the source. Meanwhile, the preparation method of the compound preparation is simple and easy to implement, so that the compound preparation has a good application prospect.

The invention discloses an establishment method of an HPLC (high performance liquid chromatography) characteristic chromatogram of granules for treating common cold and clearing heat and a component content test thereof, and belongs to the technical field of pharmaceutical analys.According to the research, the HPLC characteristic chromatogram of the granules for treating common cold and clearing heat is established under the same chromatographic condition by adopting a high performance liquid chromatography, and the overall internal quality in a preparation is comprehensively reflected; the method for simultaneously determining the content of amygdalin, puerarin, cimicifugin and corydalis bungeana is established, methodology verifies that the method is simple, convenient and feasible, has good stability and repeatability, and can be used for detection in production process monitoring and quality evaluation of the cold and heat clearing granules to ensure that the quality of the cold and heat clearing granules meets the standard. The scheme not only scientifically restores the overall pharmacodynamic material basis of the compound preparation, but also provides a new generalizable normal form for quality control of traditional Chinese medicines with the advantages of low cost and high efficiency, and has milestone significance for promoting industry standardization and internationalization.

The application relates to the technical field of beef cattle breeding, and particularly discloses a compound preparation for promoting the feed intake, daily weight gain and improving the meat quality of beef cattle and application thereof, which is prepared from the following components in percentage by volume: 40% of micro-ecological preparation, 30% of hawthorn, 10% of medicated leaven, 10% of malt, 5% of areca nut and 5% of dried tangerine or orange peel; the compound preparation is prepared from microorganisms and multiple natural Chinese herbal medicines in a specific and scientific matching ratio; experiments prove that the compound preparation can increase the feed intake of beef cattle by 11.33%, increase the daily weight gain by 16.16%, and significantly shorten the breeding cycle; meanwhile, the contents of aspartic acid, threonine, glutamic acid, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine, lysine, arginine and proline in the muscle are significantly increased, the nutritional quality and flavor taste of beef are effectively improved, the preparation is natural, residue-free and side-effect-free, the preparation method is simple, the cost is low, and the preparation has extremely high practical value and popularization prospect.

The invention provides a method for improving mixing uniformity of a medicinal compound preparation of metformin and empagliflozin, and belongs to the technical field of medicines. The invention provides an ultrasonic uniform mixing method for dry granulation. The ultrasonic uniform mixing method adopts an air jet pulverization technology, an ultrasonic-assisted vertical shaft planetary stirrer mixing technology and a forced sieving technology, and adopts a strengthening means; by utilizing the synergistic effect of ultrasound and a mixer, the mixing time is shortened, the mixing effect is enhanced, the uniformity and dissolution rate of the preparation are remarkably improved, and the method is short in process route, simple in step operation, easy in condition control and suitable for large-scale production.

The invention belongs to the technical field of traditional Chinese medicine compound preparations, and particularly relates to a qi-regulating, phlegm-reducing and nerve-calming paste, a preparation method thereof and application of the paste in preparation of a medicine for treating Parkinson's disease combined with rapid eye movement sleep behavior disorder. The paste is prepared from the following raw materials in parts by weight: 9-30 parts of semen ziziphi spinosae, 15-30 parts of Chinese yam, 10-15 parts of poria with hostwood, 9-30 parts of semen coicis, 3-10 parts of pericarpium citri reticulatae, 3-10 parts of fingered citron, 10-20 parts of sesame, 10-20 parts of rock candy and 3-5 parts of maltose. By nourishing the heart and strengthening the spleen to consolidate the root, regulating qi and reducing phlegm to relieve stagnation and tranquilizing and sedating the physique to return to the soul, the three methods are combined to achieve the purposes of tonifying without stagnation, eliminating without injury, recovering the heart and the spleen, smoothing phlegm and qi and self-hiding the soul.

The invention aims to provide a method for determining the content of main effective components of Xiaoyianmi cream and an application of the method, and aims to solve the technical problem that a Xiaoyianmi cream compound preparation is lack of efficient and accurate multi-component synchronous quality evaluation due to complex components of the Xiaoyianmi cream compound preparation. According to the method, a chromatography-tandem mass spectrometry technology is adopted, chromatography and mass spectrometry conditions are optimized, and an analysis method for simultaneously determining six components such as phloridine, piperlonguminine, piperine, N-trans-feruloyltyramine, DL-B-phenyllactic acid and pinocembrin is established. The determination method provided by the invention has the advantages of being simple and convenient to operate, high in sensitivity, good in repeatability, high in accuracy and the like, can realize rapid and synchronous determination of multi-index components in the Xiaoyi honey paste, and provides reliable technical support for quality control and standardization of the Xiaoyi honey paste.

The invention relates to the field of pharmaceutical compositions, in particular to a nintedanib-containing pharmaceutical composition or pharmaceutical composition for resisting progressive fibrotic interstitial lung disease (PF-ILD), which comprises a therapeutically effective amount of nintedanib or pharmaceutically acceptable salts, stereoisomers, solvates, prodrugs or derivatives of nintedanib, or pharmaceutically acceptable salts, stereoisomers, solvates, prodrugs or derivatives of nintedanib, or pharmaceutically acceptable salts, stereoisomers, solvates, prodrugs or derivatives of nintedanib. Optionally a pharmaceutically acceptable carrier; the composition has a synergistic inhibition effect on lung fibroblast proliferation through combined administration, can be applied to PF-ILD through inhalation combined administration or prepared into a fixed-dose inhalation compound preparation, especially to patients with idiopathic pulmonary fibrosis (IPF), and aims to solve the problems that the treatment effect is insufficient and the treatment effect is poor in the prior art. The safety and the tolerance are poor.

The invention relates to the technical field of biological medicine, in particular to an MCT oil plant extract compound preparation and application thereof in hypertension regulation. The invention aims to solve the problems that a traditional natural preparation is poor in stability, low in oral bioavailability, low in purity of active ingredients and incapable of covering multiple pathological mechanisms of hypertension. According to the compound preparation disclosed by the invention, high-purity MCT oil is taken as a carrier, a plurality of plant active ingredients are compounded to construct a multi-target synergistic system, and the oral bioavailability is improved by adopting a nano delivery system; daily taking of the compound preparation can safely and effectively help hypertensive patients to regulate blood pressure and prevent blood pressure fluctuation.

The invention discloses a duloxetine enteric-coated pellet, a compound preparation and a preparation method. The duloxetine enteric-coated pellet contains a drug-containing pellet and an enteric-coated layer, the enteric-coated layer contains hydroxypropyl methylcellulose phthalate (HPMCP), and the mass ratio of the HPMCP to the enteric-coated layer is 55.6%-90.9%; the HPMCP can be dissolved in a medium of which the pH value is more than 5.5; the weight gain of the enteric-coated layer is more than 12%. According to the duloxetine enteric-coated pellet disclosed by the invention, HPMCP is selected as an enteric-coated material for resisting ethanol dumping by optimizing the type of the material for resisting ethanol dumping and the thickness of the enteric-coated layer, so that the duloxetine enteric-coated pellet has an ethanol dumping resisting effect and an ideal dissolution speed.

The invention discloses a quality control method of a Beijing medicine compound preparation, and particularly relates to the field of quality control methods. Comprising the steps of comprehensive detection of medicinal materials, multi-component content determination, biological activity evaluation, quality consistency evaluation and the like. The quality stability of the medicinal materials is guaranteed from the source by determining the medicinal material producing area, the harvesting time and the processing technology preset standard; a biological activity detection model related to efficacy is established, and the quality standard and the efficacy are tightly combined; a compound preparation quality database is constructed, principal component analysis and clustering analysis are used for regular review analysis, and quality control standards and methods are dynamically adjusted and optimized; and a quality early warning mechanism is formulated, and quality problems are handled in time. According to the method, the quality is comprehensively controlled from multiple dimensions, the quality stability of preparations in different batches is ensured, the disjunction of the quality and the efficacy is effectively avoided, and the safety and the effectiveness of the Beijing medicine compound preparation are ensured.

This invention relates to the field of traditional Chinese medicine technology, specifically to a compound traditional Chinese medicine preparation for treating liver cancer, made from the following herbs: cinnamon twig, schisandra fruit, inula flower, immature bitter orange, peony root, scutellaria root, rhubarb, turtle shell, physalis, and wisteria vine. The weight ratio of the above herbs is as follows: cinnamon twig 9g-15g, schisandra fruit 12g-18g, inula flower 9g-15g, immature bitter orange 9g-15g, peony root 12g-30g, scutellaria root 9g-15g, rhubarb 3g-9g, turtle shell 15g-45g, physalis vine 15g-30g, and wisteria vine 15g-30g. This invention can significantly improve symptoms such as hypochondriac pain, poor appetite, depression, abdominal distension, and bitter taste in the mouth, reduce the damage to the digestive system function caused by targeted therapy, improve the quality of life for patients, reduce toxicity and increase efficacy, lower treatment costs, and prolong patient life.

The invention provides a sitagliptin and metformin sustained-release pharmaceutical composition as well as a preparation method and application thereof, and relates to the technical field of sustained-release preparations. The pharmaceutical composition comprises a sustained-release tablet core and a quick-release coating layer, the sustained-release tablet core comprises an active ingredient metformin hydrochloride and a sustained-release framework material hydroxypropyl methylcellulose, and the sustained-release tablet core does not contain microcrystalline cellulose; the quick-release coating layer comprises an active component sitagliptin phosphate; the weight ratio of metformin hydrochloride to hydroxypropyl methylcellulose in the sustained release tablet core is 50: (24-27). The composition utilizes a double-layer structure to realize double-phase release of the medicine; the microcrystalline cellulose is removed, and the specific ratio of the active component to the framework material is limited, so that the moldability and ideal dissolution behavior of the preparation are ensured while the tablet weight is remarkably reduced to improve the swallowing compliance, and the technical problem that the slow-release framework function is difficult to maintain under the condition that the weight of a high-drug-loading-capacity compound preparation is greatly reduced is successfully solved.

Provided are a protein degradation agent compound preparation method and application; specifically, provided are the compound represented by formula (I) and a pharmacologically acceptable salt thereof, and an application of said compound in the degradation of androgen receptor (AR).

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses application of a dampness-removing and itching-relieving decoction composition based on S1P-S1PRs pathway regulation in treatment of psoriasis. According to the present invention, the dampness removing and itching relieving decoction composition is used for treating psoriasis, can provide the treatment effect through multiple ways and multiple targets, can significantly improve the skin lesion condition of psoriasis patients, and can reduce the PASI score; as a traditional Chinese medicine compound preparation, the dampness-removing and itching-relieving decoction composition is small in side effect, high in safety and suitable for long-term use.