782 results about "Compounded preparations" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a pyruvate-containing composite preparation as well as a preparation method and application thereof. The composite preparation containing pyruvate is prepared from the following components in percentage by mass: 0.02 to 0.04 percent of a compound A, 0.05 to 0.1 percent of pyruvate, 0.2 to 2 percent of sodium dihydrogen phosphate, 0.2 to 2 percent of disodium hydrogen phosphate, 0.7 to 0.9 percent of sodium chloride and the balance of water for injection, the structural formula of the compound A is as follows: # imgabs0 #. The compound A and pyruvate in the compound preparation interact with each other, so that lung inflammatory response can be inhibited, the level of inflammatory factors can be reduced, and lung edema can be relieved.

The invention relates to the technical field of compositions, in particular to an anti-aging composition for increasing corium layer collagen and a preparation method of the anti-aging composition. Comprising the following steps: preparing sargassum fusiforme polysaccharide; preparing a composite sargassum fusiforme polysaccharide stabilizer; and compounding and preparing the traditional Chinese medicine extract. The anti-aging composition is prepared by compounding the balm extract, the pistacia chinensis extract, the mulberry extract, the collagen tripeptide and the sargassum fusiforme polysaccharide, all the components are properly compounded, the obtained anti-aging composition and oral liquid are not prone to precipitation in the storage process, loss of nutritional ingredients is avoided, and the anti-aging effect is good. According to the present invention, the components have the obvious synergistic effect, such that the collagen secretion can be promoted while the oxidative stress, the collagen degradation and the skin inflammation can be inhibited so as to substantially increase the collagen content of the skin corium layer, and the anti-aging effect on the skin can be effectively achieved.

The invention provides lactobacillus fermentum as well as a compound preparation and application thereof, and relates to the technical field of microorganisms. Compared with a strain in the prior art, the lactobacillus fermentum HXJS4-1 disclosed by the invention has a better effect in the aspect of nucleoside degradation and can realize rapid nucleoside degradation. In addition, the compound has a stronger inhibition effect on xanthine oxidase, and the activity of the xanthine oxidase is effectively reduced. In mouse experiments, the strain also has an obvious uric acid reducing effect, also has a certain anti-inflammatory effect, can be used in the prevention and treatment process of hyperuricemia and gout, and provides a new probiotic or drug material for the treatment of hyperuricemia and gout. In addition, eating of the strain has no obvious influence on indexes of a sample body, and it is proved that the strain has the characteristic of high safety and can be widely applied to the fields of medicine and food.

The invention relates to the field of animal breeding, and discloses a pig beta defensin compound preparation which comprises pig beta defensin PBD1, PBD2 and PBD114, and the weight ratio of the PBD1 to the PBD2 to the PBD114 is 1: 1: 1. The porcine beta defensin PBD1, the porcine beta defensin PBD2 and the porcine beta defensin PBD114 are recombinant proteins, and are respectively expressed in escherichia coli BL21 (DE3) PLysS competent cells by a pET-32a expression vector. Through the synergistic effect of the defensins PBD1, PBD2 and PBD114, the minimum inhibitory concentration (MIC) of the EPEC is reduced to 18.75 mu g / mL from 75 mu g / mL of single defensins, and is reduced by 75%; within 24 hours, the bacteriostasis rate of the compound preparation reaches 90%, and the inhibition effect on EPEC is remarkably improved.

The invention discloses an edible and medicinal composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and belongs to the technical field of functional foods. The composition consists of the following raw materials in parts by weight: 1-8 parts of ampelopsis grossedentata extract freeze-dried powder, 1-8 parts of astragalus membranaceus extract freeze-dried powder, 1-5 parts of kudzu vine root extract freeze-dried powder, 1-8 parts of hawthorn extract freeze-dried powder and 1-5 parts of cassia seed extract freeze-dried powder. The composition is designed according to a multi-component synergistic interaction principle, and the functions of protecting the liver and dispelling the effects of alcohol are enhanced through targeted interaction of active ingredients such as ampelopsis grossedentata flavone, puerarin and astragaloside; the compound preparation has the compound effects of protecting the liver, dispelling the effects of alcohol, resolving dampness, resisting oxidative stress, regulating lipid metabolism and the like, can remarkably relieve the problems of acute and chronic liver injury and metabolic disorder caused by alcohol intake, and meets the food-grade safety standard and the medicinal activity requirement; the important application prospect is realized in the aspect of preparing a preparation for relieving alcoholic liver injury and improving the liver detoxification function.

The invention relates to the technical field of medicines, and particularly discloses a compound antihypertensive pharmaceutical composition. The pharmaceutical composition provided by the invention selects sacubitril valsartan sodium and indapamide as active ingredients, and within a prescription dosage range limited by the application, the two medicines can fully realize an antihypertensive effect through a synergistic effect, and the renal function of a patient is effectively improved. Through cooperation of the two components, the hypertension symptom of a patient can be effectively controlled, the adverse reaction is not obvious, and the compliance of the patient can be improved by adopting the compound preparation, so that the control on the blood pressure of the patient is enhanced.

The invention discloses a compound preparation of calcium citrate casein phosphopeptide calcium tablets and a preparation method of the compound preparation. The compound preparation comprises the following components in percentage by weight: 90-96% of calcium citrate particles, 0.68-1.84% of casein phosphopeptide, 0.08-0.16% of vitamin D3 powder, 0.7-1.5% of vitamin K2 powder, 0.5-1.5% of sodium carboxymethyl starch and 0.6-1.0% of magnesium stearate. And 2-4% of a coating premix. The preparation method comprises the following steps: step 1, calcium citrate wet granulation; step 2, mixing; step 3, tabletting; step 4, coating; the feed is reasonable in matching and balanced in proportioning, and can supplement calcium, vitamin D and vitamin K. The compound preparation of the calcium citrate casein phosphopeptide calcium tablet can effectively avoid gastrointestinal discomfort and prevent constipation while improving the effective rate of calcium supplement. In addition, the compound preparation of the calcium citrate casein phosphopeptide calcium tablet is good in taste, convenient to carry, easy in raw material obtaining and low in production cost.

The invention discloses a preparation method of eye drops for treating glaucoma, cataract and vitreous opacification. The eye drops comprise the following components: berberine, N-acetyl carnosine and lycium barbarum polysaccharide. The specific formula comprises the following components: 0.1%-0.5% of berberine, 1%-3% of N-acetyl carnosine and 0.5%-2% of lycium barbarum polysaccharide. The invention belongs to the technical field of ophthalmic pharmaceutical preparations, and solves the problems that in the prior art, glaucoma, cataract and vitreous opacity generally need to be separately taken, the research on compound preparations is less, and the components possibly interact with one another.

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a peach kernel and safflower four-ingredient decoction compound preparation and a preparation method and a quality control method thereof. The invention provides a preparation method of a peach kernel and safflower four-component decoction compound preparation by screening and optimizing an enrichment method of volatile oil in extraction, concentration, inclusion and drying processes on the basis of an ancient water decoction process. According to the peach kernel and safflower four-drug decoction compound preparation prepared by the invention, the quality consistency with a reference sample is realized, including the consistency of each content index in the compound preparation with the reference sample and the consistency of a fingerprint spectrum with the reference sample; especially, characteristic peaks of volatile components-ligustilide, senkyunolide I and senkyunolide A are presented in the fingerprint spectrum, and the consistency of the content of the volatile oil is determined. Moreover, the quality control method provided by the invention is expected to be used for quality control of industrial large-scale production of a classic famous prescription, namely the peach kernel and safflower four-ingredient decoction compound preparation, and has a good application prospect.

The invention relates to a compound preparation for improving the physique of weak stiff livestock. Every 100 ml of the compound preparation mainly comprises the following components according to a ratio: 0.1 to 0.3 g of vitamin E, 1 to 3 g of lactobacillus, 1 to 2 g of bile acid, 1 to 3 g of xylanase, 0.2 to 0.4 g of vitamin B1, 0.2 to 0.4 g of vitamin B2, 0.2 to 0.4 g of vitamin B6, 0.2 to 0.4 g of vitamin B12, 1 to 3 g of nicotinamide, 0.5 to 1.0 g of butafosfan, 1 to 3 g of taurine, 1 to 3 g of lysine, 0.5 to 1.0 g of levamisole hydrochloride, 5 g of soybean oil, 50 g of gelatin liquid, 5 to 10 ml of sodium sulfate solution, 1 to 2 g of Pickering emulsifier, 3 to 5 g of liquid paraffin and 1 to 2 g of Tween-80. The compound preparation not only pays attention to nutritional supplement, but also pays attention to regulation of an immune system and improvement of intestinal flora balance, so that the physique of the weak stiff livestock is comprehensively improved, and powerful support is provided for efficient development of the breeding industry.

The invention discloses a traditional Chinese medicine effective component compound preparation for inhibiting colorectal cancer transformation, which is composed of palmatine, berberine, coptisine and aesculin, and the mass ratio of the palmatine to the berberine to the coptisine to the aesculin is 3: 3: 1: 3. The traditional Chinese medicine active ingredient compound preparation can be prepared into clinical common preparations including granules, capsules or oral liquid according to a conventional method. The traditional Chinese medicine effective component compound preparation disclosed by the invention is proved to be capable of inhibiting intestinal inflammation, improving the intestinal barrier function and remarkably inhibiting colorectal tumor in an inflammatory state by intervening a mouse DSS induced chronic colitis model and an AOM / DSS combined induced colitis and proctitis cancer transformation model.

The invention discloses a compound for treating cow mastitis in the technical field of veterinary drugs. The present invention uses salt spike wood, dandelion and whitehead to form a compound preparation to form a compound for treating cow mastitis. The present invention utilizes the characteristics of three traditional Chinese medicines that do not produce drug resistance, reducing the generation of drug resistance of pathogenic bacteria; the results of the treatment test on mice show that the present invention has a good therapeutic effect on mice infected with pathogenic Staphylococcus aureus; by detecting the content and activity of ALP, NAG and LDH in the whey and serum of sick cows, it is proved that after the present invention is used, the activity of ALP, NAG and LDH in the cow body is significantly reduced and reduced to the standard range, indicating that the present invention has a good therapeutic effect on cow mastitis, and 1.5 times the therapeutic amount has the best effect, and the treatment time can be shortened; the results of the drug stability test of the present invention show that the antibacterial effect of the present invention is not affected by high pressure and pH changes between 6.0-7.5, and the present invention can be used for clinical treatment after high pressure treatment.

The invention discloses a gradient alcohol extraction preparation method of compound honeysuckle flower drops for improving T cell activity, and relates to the technical field of traditional Chinese medicine compound preparations, honeysuckle flower and radix astragali are selected for pretreatment, an ethanol aqueous solution and an interaction regulating agent are added for infiltration, an online traditional Chinese medicine compound preparation HPLC is adopted for dynamic alcohol concentration adjustment and temperature extraction under monitoring of the traditional Chinese medicine compound preparation, the method disclosed by the invention has the advantages that the interaction regulating agent is added in the raw material infiltration stage to block bad interaction among active components, and the online monitoring system is utilized to dynamically adapt the ethanol concentration and the extraction temperature to realize step-by-step efficient dissolution of the multi-polar components; the antioxidant is matched to inhibit oxidation of thermosensitive components, and the solubilizer assists dissolution of insoluble components, so that the core defect that synergistic extraction of multi-polar active components, degradation of the thermosensitive components and interaction inhibition of the components in the compound honeysuckle flowers cannot be considered in the prior art is overcome, and loss or antagonism of the active components is effectively avoided.

The invention relates to the technical field of traditional Chinese medicine formulas for treating hypertension, in particular to a traditional Chinese medicine compound preparation for treating liver-yang hyperactivity type hypertension or yin deficiency and yang hyperactivity type hypertension as well as a preparation method and application of the traditional Chinese medicine compound preparation for treating liver-yang hyperactivity type hypertension or yin deficiency and yang hyperactivity type hypertension. The medicinal materials comprise gastrodia elata, uncaria, fried stiff silkworm, cornu bubali, concha haliotidis, selfheal, radix cyathulae, salted eucommia ulmoides, salted semen plantaginis and fried spina date seed. The preparation method comprises the following steps: decocting a required amount of buffalo horn with water to obtain a buffalo horn decoction; soaking other medicinal materials except the uncaria in water, decocting the soaked medicinal materials and the cornu bubali decoction for two to three times, adding the uncaria into the decoction five to seven minutes before the last decoction, and combining the decoction to obtain the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation disclosed by the invention has a blood pressure lowering effect on people with different symptoms of hypertension, is stable in blood pressure lowering and reliable in effect, and has the effects of nourishing yin, suppressing yang, calming the liver and calming the heart.

The invention relates to the field of functional food and pharmaceutical preparations, and discloses an active multienzyme preparation with spleen and stomach strengthening effects. The solid beverage is prepared from the following components in parts by weight: 10 to 20 parts of radix astragali seu hedysari extract, 5 to 10 parts of rhizoma atractylodis macrocephalae extract, 10 to 20 parts of poria cocos extract, 5 to 10 parts of pericarpium citri reticulatae extract, 5 to 10 parts of fructus crataegi extract, 5 to 10 parts of malt extract, 5 to 10 parts of alpha-amylase, 5 to 10 parts of protease, 2 to 5 parts of cellulase, 2 to 5 parts of pectinase, 2 to 5 parts of lipase, 10 to 15 parts of prebiotics, 2 to 5 parts of xylitol and 3 to 8 parts of microcapsule wrapping materials. The compound preparation with high stability and multiple functions is prepared by scientifically combining traditional Chinese medicine extracts and multiple active enzymes, combining with reasonable addition of prebiotics and auxiliary materials, adopting a micro-capsule wrapping technology to protect enzyme activity and optimizing traditional Chinese medicine extraction, component mixing and forming processes.

The present invention relates to a linker-drug preparation method, and particularly provides a target compound preparation method, which comprises: reacting a compound represented by a formula a with Lewis acid to obtain a crude product; and purifying the crude product to obtain the compound as shown in the formula A. The preparation method can reach the quality control standard of the product.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine compound preparation for preventing and treating sepsis based on intestinal treatment and gasification regulation and a preparation method and application of the traditional Chinese medicine compound preparation. The composition is prepared from the following medicinal materials in parts by weight: 3 to 10 parts of rheum officinale, 5 to 10 parts of fructus aurantii, 5 to 10 parts of radix aucklandiae, 10 to 15 parts of fructus gardeniae, 10 to 15 parts of dandelion, 10 to 15 parts of fructus forsythiae, 10 to 15 parts of herba artemisiae scopariae, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of radix paeoniae rubra, 10 to 15 parts of radix salviae miltiorrhizae, 15 to 20 parts of astragalus membranaceus, 10 to 15 parts of rhizoma anemarrhenae, 10 to 15 parts of fructus cannabis, 10 to 15 parts of semen pruni and 3 to 6 parts of raw liquorice. The traditional Chinese medicine compound provided by the invention considers the treatment rules of relaxing bowels, purging heat, promoting qi circulation, removing stagnation, detoxifying, dispersing blood stasis, reinforcing qi, nourishing yin and the like, and also considers the effects of relaxing bowels, regulating qi and supporting healthy qi, various diseases of sepsis patients can be remarkably improved through the synergistic effect of the medicines in the formula, and the traditional Chinese medicine compound especially has an obvious curative effect on gastrointestinal dysfunction. A novel traditional Chinese medicine treatment thought is provided for clinical treatment of sepsis diseases.

The invention discloses a preparation method of 20 (E)-ginsenoside F4 and application of the 20 (E)-ginsenoside F4 in preparation of anti-liver injury medicines, and relates to the technical field of biological medicines. The rare ginsenoside 20 (E)-ginsenoside F4 is prepared and purified from ginsenoside Re through an acid catalytic conversion method, and the rare ginsenoside 20 (E)-ginsenoside F4 shows remarkable advantages and wide prospects in research and development of liver protection drugs. The monomer has strong liver protection activity, complies with the development trend of monomeric compound preparations, and provides efficient active ingredients for liver protection drugs. The 20 (E)-ginsenoside F4 with efficient activity, excellent safety and environment-friendly preparation characteristics can be widely applied to preparation of liver protection drugs or pharmaceutical compositions, especially drugs or pharmaceutical compositions for treating liver injury caused by chemotherapeutic drugs.

The application provides a Chinese medicine compound preparation for preventing and treating respiratory tract infection of livestock and poultry, a preparation method and application, and relates to the technical field of animal medicine. The Chinese medicine compound preparation is composed of 10 Chinese medicines, i.e. honeysuckle, forsythia, inula flower, platycodon grandiflorum, euphorbia helioscopia, xiaochangqing, fresh eucalyptus globulus, fried stemona, cat's claw and augustifolia, follows the principle of Chinese medicine syndrome differentiation and treatment, is reasonably matched, and the medicines are coordinated with each other to increase the efficacy. The Chinese medicine compound preparation can significantly reduce the levels of TNF-alpha and IL-6 in serum, increase the level of IFN-gamma, obviously alleviate the clinical symptoms of livestock and poultry respiratory tract infection, reduce the mortality, has a good treatment effect on the related diseases of livestock and poultry respiratory tract infection, can improve the drug resistance of antibiotic drugs, reduce the drug residues of chemical agents in livestock and poultry, and guarantees the health of livestock and poultry and the safety of animal source food.

The invention provides a memantine hydrochloride sustained-release pellet preparation with simple components and a compound capsule containing the memantine hydrochloride sustained-release pellet and donepezil, and provides a preparation method of the memantine hydrochloride sustained-release pellet preparation. The compound capsule has equivalent dissolution effect with a reference preparation # imgabs0 #, is good in stability and simple in preparation process, overcomes the defects of complex components and tedious process of the existing preparation, is convenient to operate, and reduces the manufacturing cost.

The method comprises the following steps: dissolving lipoic acid and a drug in an organic solvent to form a homogeneous solution, dropwise adding deionized water while stirring, then adding a reducing agent, initiating lipoic acid polymerization and drug co-assembly in situ at 20-40 DEG C to form a drug-loaded micelle solution, and carrying out freeze drying on the drug-loaded micelle solution to obtain the nano-preparation drug based on polylipoic acid. And dialyzing and purifying to obtain the nano preparation medicine based on polylipoic acid. The preparation method is characterized in that lipoic acid has dual characteristics of a drug carrier matrix and a dynamic crosslinking monomer, carrier synthesis and efficient drug encapsulation are synchronously realized through one-step in-situ polymerization-co-assembly, and the technical bottleneck that a traditional nano-carrier needs pre-synthesis and step-by-step drug loading is broken through. The method has the following practicability: (1) the process is simple and efficient, complex equipment is not needed, and reaction conditions are mild; (2) the drug loading performance is excellent, and the particle size is uniform and adjustable (50-300 nanometers); (3) a polylipoic acid skeleton endows the nano-drug preparation with environmental responsiveness, and intelligent drug release can be realized; and (4) the method is suitable for hydrophobic drugs and compound preparations. The method provides a high-load, high-stability and stimuli-responsive nanocrystallization solution for hydrophobic drug delivery, and has application value in the field of nano-medicines.

The invention discloses a traditional Chinese medicine composition for treating fatty liver diseases related to metabolic dysfunction. The traditional Chinese medicine composition is prepared from the following raw material medicines: Qu fructus aurantii, lotus leaves, semen cassiae, gynostemma pentaphylla, rhizoma alismatis, rhodiola rosea, radix salviae miltiorrhizae, pseudo-ginseng and rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition and the traditional Chinese medicine compound preparation disclosed by the invention can improve the blood sugar and blood fat levels of fatty liver diseases related to metabolic dysfunction and improve the metabolic level, are remarkable in clinical curative effect, improve the living quality of patients, have the effects of regulating qi, soothing the liver, tonifying the spleen and removing stasis, slow down liver fibrosis by improving blood sugar and blood fat metabolism, and are quick in curative effect and low in price.

The invention relates to the technical field of traditional Chinese medicine detection, in particular to a quality control method of a heart fire clearing lotus seed beverage compound preparation, which comprises the following steps: respectively preparing test solution A-E; based on the test solution A, identifying the scutellaria baicalensis by adopting a thin-layer chromatography; identifying cortex lycii radicis and liquorice based on the test solution B, identifying ginseng based on the test solution C, identifying semen plantaginis based on the test solution D, and identifying lotus seeds based on the test solution E. According to the method, repeated extraction of the reference sample during identification of different medicine flavors can be reduced, and the method has the advantages of clear spots, good separation degree, strong specificity, no background interference and good durability.

The invention discloses a strong-absorption water-soluble lutein compound preparation and application thereof in food with an eyesight protection function. The xanthophyll-dipotassium glycyrrhizinate water-soluble granules are water-soluble granules formed by molecular self-assembly of xanthophyll, dipotassium glycyrrhizinate, triterpenic acid, protein and dietary polysaccharide. Compared with untreated xanthophyll, the xanthophyll compound preparation with strong absorption has the advantages that the xanthophyll has good water solubility and stability, the intestinal absorption efficiency is improved by 20-35 times, and eyesight protection can be effectively realized. Meanwhile, the embedding rate is high, the safety is good, and the production cost is low.

The invention provides a pharmaceutical composition and application thereof in preparation of a compound preparation, and belongs to the field of medicines. The pharmaceutical composition comprises a potassium ion channel opener, a 5 alpha-reductase inhibitor and a phosphodiesterase 5 inhibitor. The pharmaceutical composition can synergistically promote treatment of androgen dependent diseases or prevention of complications, and by taking the pharmaceutical composition of minoxidil, finasteride and tadalafil as an example, the effects in a benign prostatic hyperplasia rat model and an androgenic alopecia mouse model are verified, which indicates that the minoxidil, finasteride and tadalafil have a synergistic interaction effect, and the pharmaceutical composition can be used for treating the androgen dependent diseases or preventing the complications. Good clinical application prospects are realized.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a kidney-tonifying and liver-nourishing compound preparation and a preparation method thereof. The compound preparation comprises 5-15 parts of roasted herba epimedii, 5-15 parts of fructus cnidii, 50-70 parts of roasted radix astragali and 10-30 parts of pulp of dogwood fruit. The traditional Chinese medicine composition has remarkable curative effects on various diseases and chronic strain caused by deficiency of liver and kidney and deficiency of blood and essence, such as dizziness, blurred vision, fatigue, swelling and pain of waist, back and limbs, dry mouth and eyes, limb ache and weakness, irregular menstruation, incapability of holding weight or hemiplegia and the like, and has a very good application prospect.

The invention provides a compound preparation for reducing the toxic effect of zearalenone of bred animals as well as a preparation method and application of the compound preparation, and belongs to the technical field of medicines for livestock and poultry. The invention provides a compound preparation for reducing the toxic effect of zearalenone of bred animals. The compound preparation is prepared from the following components in parts by weight: 40 to 50 parts of total flavonoids of radix astragali seu hedysari, 0.1 to 0.4 part of selenium-enriched yeast, 10 to 15 parts of modified montmorillonite and 1 to 4 parts of vitamin C. The four components in the compound preparation are mutually matched and synergistically synergized to reduce the toxic effect of zearalenone and resist zearalenone poisoning of bred animals, and the compound preparation has high safety, so that the production performance of the bred animals and the quality of animal-derived products are improved, the green and healthy development of animal husbandry is promoted, the preparation method is simple, the cost is low, and the compound preparation is suitable for industrial production. The method is suitable for large-scale production and application.

The invention discloses a donepezil and memantine compound sustained release preparation and a preparation process thereof, and belongs to the technical field of pharmaceutical preparations. The preparation consists of a donepezil hydrochloride quick-release layer and a memantine hydrochloride slow-release layer, wherein the quick-release layer comprises donepezil, starch, mannitol and the like, and realizes quick disintegration through granulation of a low-substituted hydroxypropyl cellulose aqueous solution; the slow-release layer comprises memantine, pinoresinol diglucoside, a polylactic acid-glycolic acid copolymer and chitosan, and the slow-release layer and the composite slow-release material have a synergistic effect through a low-temperature grinding technology, so that the degradation of the memantine is inhibited, and the sustained release of the memantine is controlled. The problem that an existing compound preparation is poor in stability is solved, and a safe and effective treatment choice which is taken once a day is provided for a patient suffering from the Alzheimer disease.

The invention discloses an application of two collagen peptides with hematopoietic activity, a collagen hydrolysate containing the collagen peptides and a compound of the collagen peptides. The collagen peptides with hematopoietic activity, the collagen hydrolysate containing the collagen peptides and the compound of the collagen peptides comprise one or a combination of the following polypeptides: 1) a polypeptide of GSAGPpGATGFpGAAGR (p is hydroxyproline), and 2) a polypeptide of which the amino acid sequence is GAAGLpGPK (p is hydroxyproline). The invention also provides a preparation method and application of the collagen peptide with hematopoietic activity and the collagen hydrolysate containing the collagen peptide, the two collagen peptides with hematopoietic activity and the compound thereof have good hematopoietic activity and an effect of relieving hematopoietic inhibition, are non-toxic, can be easily used as functional factors to be added into various health-care foods, and have good health-care effects. Good market prospects are realized in medicine and food industries.

The invention discloses a compound preparation capsule and a preparation method thereof, wherein the compound preparation capsule is composed of Vonoprasone or a pharmaceutical salt microtablet thereof, an amoxicillin microtablet and a rifampicin or rifampetine microtablet. The Vonoprazan is a novel potassium ion competitive acid blocker, and the compound preparation capsule is used for treating gastric ulcer, duodenal ulcer, gastric MALT lymphoma, idiopathic thrombocytopenic purpura, and helicobacter pylori infection and helicobacter pylori infection gastritis in the stomach after early gastric cancer endoscopic therapy. According to the compound preparation capsule, the cure rate of helicobacter pylori can be increased, the drug resistance can be reduced, and a better treatment choice is provided for clinical patients.