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2854results about How to "High drug loading" patented technology

Stabilized Hme Composition With Small Drug Particles

A hot-melt extruded composition having finely divided drug-containing particles dispersed within a polymeric and/or lipophyllic carrier matrix is provided. The carrier softens or melts during hot-melt extrusion but it does not dissolve the drug-containing particles during extrusion. As a result, a majority or at least 90% wt. of the drug-containing particles in the extrudate are deaggregated during extrusion into essentially primary crystalline and/or amorphous particles. PEO is a suitable carrier material for drugs insoluble in the solid state in this carrier. Various functional excipients can be included in the carrier system to stabilize the particle size and physical state of the drug substance in either a crystalline and/or amorphous state. The carrier system is comprised of at least one thermal binder, and may also contain various functional excipients, such as: super-disintegrants, antioxidants, surfactants, wetting agents, stabilizing agents, retardants, or similar functional excipients. A hydrophilic polymer, such as hydroxypropyl methylcellulose (HPMC E15), polyvinyl alcohol (PVA), or poloxamer, and/or a surfactant, such as sodium lauryl sulfate (SLS), can be included in the composition. A process for preparing the extrudate is conducted at a temperature approximating or above the softening or melting temperature of the matrix and below the point of solubilization of drug-containing particles in the carrier system, and below the recrystallization point in the case of amorphous fine drug particles.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST

Health product oral fast-release preparation and production method thereof

The invention relates to a health product oral fast-release preparation and a production method thereof. The basic raw material of the preparation comprises main material and auxiliary material. The main material is health product raw material. The auxiliary material is oily dispersant mainly, and water-soluble dispersant, flavouring and emulsifier are added when necessary. The weight percentage of the main material is 0.1 percent to 80 percent, and the weight percentage of the auxiliary material is 20 percent to 99.9 percent. The method comprises the following steps: (1) preparing materials;(2) preparing slurry, including thinning and liquidizing, the finial fineness of the thinning is that 80 percent of the weight of the preparation is less than 300 microns, and the liquidizing processis that solid particles are dispersed in the oily dispersant in a stirring way. The weight percentage of the addition quantity of the oily dispersant can satisfy that the oil content in a finished product is not less than 15 percent; (3) molding that a finished product preparation is manufactured by a cooling molding method or a powder molding method. The health product oral fast-release preparation of the invention improves the dispersing speed of health product component in mouth under the precondition of achieving good flavor and is convenient for people to take without drinking water.
Owner:何煜
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