137 results about "Coptisine" patented technology

The invention relates to preparation method and application of berberine fatty group organic acid salt, pertaining to pharmacy field. The chemical general formula of barberine type alkaline of the invention is shown as a formula (I), wherein, X represents organic acid group, and the berberine type alkaline is berberin, palmatine, jaterohitine or coptisine. The invention relates berberine alkaline fatty group organic acid, which is of good oral taking absorption, can be used for preparing medical components, greatly improves the bio-availability of the alkaline type, and play comparatively better effect to the therapies of such diseases as bacterial infection, heart rate abnormity, platelet aggregation, hyperlipidemia, diabetes, hypertension, cardiac failure, etc.

The invention pertains to topical pharmaceutical formulations of berberine and its biologically equivalent analogues, such as palmatine and coptisine, for the treatment of rosacea and other red face-related skin disorders. The topical pharmaceutical formulations of this invention contain purified berberine as the primary active drug ingredient at concentrations higher than 0.1%. The invention also pertains to methods of treating rosacea and other red face related skin disorders, such as steroid-induced rosacea-like dermatitis, comprising the administration of topical pharmaceutical formulations that contain berberine or its biologically equivalent analogues, such as palmatine.

The invention relates to the extraction technology of a rhizoma coptidis total alkaloid and the process flow is as follows: raw materials (rhizoma coptidis or coptis fibrous roots or coptis leaves), pulverization (Coptis fibrous roots or coptis leaves need no pulverizing.), addition of right amount of sulphuric acid of 0.01 to 10 percent for soaking, heated extraction for four times, preconcentration, sediment of sodium chloride and high-valencied metal salt, filtration, drying and products of rhizoma coptidis total alkaloid. The main active ingredients for the product are berberine, coptisine, jateorrhizine, palmatine, epiberberine and other active coptis ingredients, the content of rhizoma coptidis total alkaloid is over 20 percent, wherein, the content of berberine is over 10 percent. The product adopts coptis fibrous roots and so on as raw materials to extract rhizoma coptidis total alkaloid, which is different from the traditional extraction of berberine. The extraction technology improves the pure quotient of the product and particularly eliminates cold-natured ingredients of toxic and side effect through the operating procedure of impurity eliminating, thereby improving the product quality. Besides the traditionally-utilized berberine, the product still contains a large quantity of other active coptis ingredients such as coptisine, jateorrhizine, palmatine, epiberberine and so on. The product has a higher utilization rate of resources and a higher security of products, and the effective function and action of rhizoma coptidis can be brought into a better play.

The invention discloses a method for extracting coptisine, which comprises the following operations: extracting raw materials by acid, neutralizing an acid extract, precipitating to remove impurities, precipitating to remove berberine, regulating the basicity of a solution, separating by a chromatographic column, precipitating, crystallizing and drying a crystal product to obtain a product. The invention takes at least one of coptis root, yellow-corktree bark and radix berberidis as the raw materials, is combined with the physicochemical characteristics of various components in the alkaloid of the coptis root and further realizes the effective separation of jateorrhizine, coptisine and palmatine by the chromatographic operation on the basis of the extraction of the berberine. The method has simple process, easy execution, good repeatability and low cost and can be widely used for the large-scale production of coptisine, and the extraction efficiency of coptisine is high. The purity of the coptisine in the product prepared by the method can reach more than 90%, and the coptisine can be completely used as the raw material of medicines for resisting bacteria, lowering sugar, lowering blood fat, resisting cancer, promoting the power of the stomach and the like and can also be used as the raw material of other products.

The invention relates to an extraction method of high-purity coptis total alkaloid, which comprises the following steps: preparing a raw material (coptis or coptis fibril or coptis ash), pulverizing (not required if the raw material is coptis fibril or coptis ash), immersing in 0.1-5% sulfuric acid, heating and extracting four times, filtering, neutralizing with calcium oxide (or calcium hydroxide), filtering, washing the precipitate, preconcentrating, regulating the acid, precipitating with sodium chloride, filtering, recovering alkaloid from the mother liquor, and drying the precipitate to obtain the coptis total alkaloid product. The main active components of the product are coptis effective components, such as berberine, coptisine, palmatine, epiberberine, jateorhizine and the like; the coptis total alkaloid content is more than 50%; and the berberine content is more than 25%. The product provided by the invention has favorable actions of lowering blood sugar and blood fat, losing weight and the like, and is an ideal raw material for treating diabetes and cardiovascular diseases.

The present invention discloses a medicine for resisting virus, raising immunity of human body and curing AIDS. Said medicine is a pure Chinese medicine preparation, and is made up by using 37 Chinese medicinal materials of licorice, radix trichosanthis, salvia root, dandelion herb, scutellaria root, coptis, phellodendron bark and others.

The invention discloses a medicament for treating dermatophytosis, especially applicable to the people who suffer from the dermatophytosis and work outside all day without a rest. The medicament for treating the dermatophytosis can remove the dermatophytosis fundamentally, detoxify and relieve the itching without side-effect. The components for preparing the compound medicament for treating dermatophytosis in percentage are: 40-60% of vitamin B, A 40-60% of vitamin, 10-30% of lightyellow sophora root, 10-30% of chinaberry bark, 6-20% of herba schizonepetae, 20-40% of rhizoma coptidis, 10-30% of Baikal skullcap root, 10-30% of amur corktree bark, 10-30% of artemisia capillaris, 40-80% of dried alum, 12-14% of borneol, 6-10% of sandalwood, 6-15% of curcuma zedoary, 26-70% of gypsum fibrosum, 20%-40% of cnidium monnieri, 1-3% of poria cocos, 1-3% of broom cypress fruit, 1-3% of periostracum cicada, 1-3% of cortex dictamni, 1-3% of flax kernel, 1-3% of amur corktree bark, 1-3% of angelica root, 1-3% of Sichuan pepper, 2-4% of dried alum, 2-4% of lithospermum, 0.5-3.5% of centipede, 5-15% of radix achyranthis bidentatae, 1-5% of root of stephaniatetrandraS.Moore, and 1-5% of akebia stem.

The invention discloses a traditional Chinese medicine composition for treating oral ulcer. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients: gypsum, calamine, natural indigo, borneol, dried alum, dark plum fruit, mint, oyster, pearl, calculus bovis, radix scutellariae, coptisine hydrochloride, coix seed, amur corktree bark, radix sophorae flavescentis, licorice roots northwest origin, Chinese gentian root, Chinese gall, dandelions, sediment of human urine, realgar, carbonized spider, ivory chips, abroma angusta, wusuli dragonflyorchis rhizome, anhydrous sodium sulphate and alumen. The composition has the functions of clearing away heat and toxic materials, relieving swelling and pain, removing necrotic tissue and promoting granulation and astringing to stop bleeding, is mainly used for treating oral ulcer caused by endogenous pathogenic heat, has simple preparation processes and small toxic and side effects, is convenient to administrate, is easy to prepare, is low in cost, can directly treat focuses, ensures short cure time and avoids relapse after cure.

The invention discloses an application of protoberberine alkaloid to prepare anti-drug tolerant bacterial drug, in particular to an application of compound coptisine, dehydrokaweidin and dihydroapokaweidin in the anti-drug tolerant bacterial drug, which is characterized by the following: extracting protoberberine from Corydalis saxicola Bunt. of Corydalis of Papaveraceae; displaying obvious inhibition for MRSA in the clinic through pharmacological test; using the compound protoberberine alkaloid as active component to make the drug to treat anti-drug tolerant bacterial drug.

The invention discloses an application of coptisine or physiologically acceptable salt thereof in preparing medicines for preventing and curing myocardial ischemic diseases. The coptisine or the physiologically acceptable salt thereof has pharmacological actions of protecting myocardial ischemic injury as well as preventing and curing myocardial ischemic diseases, has an effect of protecting myocardial mitochondria function, and has pharmacological actions of eliminating superoxide anion radical and protecting cardiocytes from being injured by free radicals. The invention discloses a compound containing the coptisine or physiologically acceptable salt and a pharmaceutically acceptable carrier and / or accessory. The coptisine is a monomeric compound extracted from rhizoma coptidis and other commonly used traditional Chinese medicines or folk herbs, which has the advantages of low toxicity and wide raw material resources.

The invention relates to a method for extracting epiberberine, coptisine, palmatine and berberine from golden thread. In the method, the golden thread is used as a raw material. The method comprises the following steps: (1) preparing crude extractive; (2) pre-separating by acid dissolution and alkaline precipitation; and (3) purifying with high-speed countercurrent chromatograph so as to obtain the epiberberine, the coptisine, the palmatine and the berberine, the concentrations of which are above 98%. In the method, ethanol is used for extracting alkaloid in a golden thread medicinal material, pre-separation is carried out by acid dissolution and alkaline precipitation, and purification is carried out with high-speed countercurrent chromatograph, thus the method disclosed by the inventionhas an environment-friendly process and no serious damage on environment.

The invention provides a traditional Chinese medicine for treating gastropathy, which has a good curative effect, short treatment course and high cure rate and does not have toxic or side effects. In the solution, the traditional Chinese medicine is subjected to formula composing by the mechanism of the homology of medicines and foods in traditional Chinese medical science according to the pathogeny of the gastropathy. In the technical scheme, the traditional Chinese medicine for treating the gastropathy is characterized by being prepared by decocting the following compositions in part by weight: 5 to 15 parts of blast-fried ginger, 10 to 30 parts of wrinkled gianthyssop herb, 10 to 30 parts of rose, 10 to 30 parts of villous amomum fruit, 10 to 30 parts of golden thread, 10 to 30 parts of white paeony root, 10 to 30 parts of largehead atractylodes rhizome, 10 to 30 parts of radish seed, 10 to 30 parts of immature bitter orange, 10 to 30 parts of cuttlefish bone, 10 to 30 parts of liquoric root, 10 to 30 parts of round cardamom fruit, 10 to 30 parts of bupleurum, 10 to 30 parts of yanhusuo, 10 to 30 parts of costus root by the conventional method. The traditional Chinese medicine is easy to prepare, and has wide medicinal sources, a quick curative effect, radical treatment, low cost and high cure rate.

The invention provides a Shuanghuanglian medicinal composition. A method for preparing the Shuanghuanglian medicinal composition comprises the following steps of: mixing and extracting honeysuckle and fructus forsythiae to obtain a honeysuckle and fructus forsythiae extract; extracting scutellaria baicalensis to obtain a scutellaria baicalensis extract; and mixing the honeysuckle and fructus forsythiae extract and the scutellaria baicalensis extract to obtain the Shuanghuanglian medicinal composition, wherein the weight ratio of the honeysuckle to the fructus forsythiae to the scutellaria baicalensis is 1:2:1; and the medicinal composition comprises the following components in percentage by weight: 20 to 40 percent of total flavone, 5 to 20 percent of total saponins, 20 to 30 percent of total organic acid, 8 to 18 percent of saccharides, 0.2 to 2 percent of total amino acid and 0.35 to 1.0 percent of phillyrin. In the Shuanghuanglian medicinal composition, active ingredients are extracted and separated from the honeysuckle, the fructus forsythiae and the scutellaria baicalensis, the impurities and the inactive ingredients are removed, each active ingredient is proportioned reasonably, and the content of chlorogenic acid and caffeic acid is strictly limited, so that curative effect is ensured and safety is improved.

The invention discloses a pharmaceutical composition for preventing and treating rheumatoid arthritis. The traditional Chinese medicine raw materials for constituting active ingredients of the pharmaceutical composition by weight are as follows: 5.5-6.0mg of berberine, 0.3-0.4mg of palmatine, 1.5-2.0mg of jatrorrhizine, 1.5-1.8mg of magnoflorine, 0.1-0.2mg of phellodendrine, 0.2-0.3mg of coptisine, 55-60mg of baicalin, 1.5-2.0mg of baicalein, 5.0-7.0mg of wogonoside, 0.03-0.05mg of wogonin, 20-25mg of geniposide, 0.1-0.2mg of crocin and 0.25-0.3mg of chlorogenic acid. The results of pharmacological tests show that the pharmaceutical composition can significantly reduce the disease severity of CIA mice with the rheumatoid arthritis, significantly improve the inflammation and the immune injury situation at lesion sites in comparison with a control group and be used for preparing drugs for preventing and treating the rheumatoid arthritis.

The invention discloses a method for preparing coptisine from coptis mixed alkaloid based on common basic structural characteristic. The coptisine is synthesized by using the coptis mixed alkaloid consisting of berberine, coptisine, palmatine and jateorhizine which have the same isoquinoline ring structure, and by performing reductive hydrogenation, hydroxylation of methoxy group and methylenedioxy group, cyclization of ortho-oxhydryl group and oxidative hydrogenation, wherein the total yield can reach 16 percent. Compared with the conventional method for preparing the coptisine, the method is simple and convenient, and easy to operate and eliminates the purification step of the raw material during the synthesis of medicaments. By the method, the rough mixed total alkali with indefinite medicinal effect dispersion and low purity is converted into monomer coptisine with high antibacterial specificity and activity. The method is easy and convenient to operate, low in cost and wide in application prospect, is suitable for batch production of the coptisine, can provide reference idea for research on conversion of main components of other Chinese herbal medicines which have similar structures, and has great guidance significance for the improvement on the utilization value of the traditional Chinese medicine and the development and preparation of new medicaments.

The invention discloses a method for separating and purifying coptisine monomers, comprising the steps of extracting, concentrating, leaching, dissolving and filtering, performing preparative high performance liquid chromatography and separating, recycling products and the like. The method of the invention has simple and convenient operation, short production cycle, high separating efficiency, stable process and low cost, and can realize preparing great amount of the high-purity coptisine monomers by separation; and the obtained coptisine monomers have high purity, and can be used as comparison products in assaying.

The invention discloses a compound Chinese medicine extract preventing arteriosclerosis, comprising the following effective ingredients: dried alcohol, Beta-sitosterol, hexacosanoic acid, butenolide III, oleanolic acid, berberine, jateorhizine, coptisine, salvianic acid A, salvianolic acid B, ring-tetracosane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin, specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1, encommiol and the like. A preparation method of the extract is as follows: taking salvia miltiorrhiza, fructus ligustri lucidi, rhizoma coptidis, cirsium japonicum, eucommia bark, atractylodes macrocephala koidz, radix pseudo-ginseng and bergamot as raw materials, conducting C1-3 alcohol extraction and / or water extraction on a total extract, then extracting the total extract by organic solvents with different polarities so as to obtain all the effective ingredients, and finally mixing the effective ingredients so as to obtain the compound Chinese medicine extract preventing arteriosclerosis. As for the compound Chinese medicine extract, a large number of ineffective chemical ingredients are removed, so that the content of effective ingredients is improved greatly, the influence on product processing and preparation quality caused by the ineffective ingredients is reduced, the preparation process is stable, the product quality is controllable, and the mass production is facilitated.

The invention provides a traditional Chinese medicine composite for treating chicken histomoniasis and a preparation method thereof. The traditional Chinese medicine composite comprises 10-30 parts ofcoptis chinensis, 10-30 parts of scutellaria baicalensis, 10-30 parts of golden cypress, 5-15 parts of oriental wormwood, 5-15 parts of kuh-seng, 5-10 parts of hairyvein agrimony, 2-7 parts of commoncnidium fruit, and 10-30 parts of the root of Chinese pulsatilla according to the weight pars which are prepared into oral solution by decocting and concentrating; the traditional Chinese medicine composite for treating chicken histomoniasis not only can promote histomonas meleagridis and toxins thereof to be discharged from body, but also can inhibit the growth and reproduction of polypides in the body, addresses both the symptoms and root causes of histomonas meleagridis, eases the problem to a certain degree that chicken is limited to be sold and exported owing to medicinal residue; the traditional Chinese medicinal plants are prepared into oral solution, thus omitting procedures involved in feed preparation; the preparation method thereof is simple and convenient and suitable for requirements of large-scale industrial production.

The present invention relates to a Chinese medicine ointment for effectively curing burn and scald with obvious therapeutic effect. It is made up by using 9 Chinese medicinal materials of Chinese angelica root, dahurian angelica root, puccoon, coptis root, dragon's blood and others.

The invention relates to a new chemical substance with a chemical name of long-chain alkyl coptisine halate derivative (hydrochloride or bromate or iodate or hydrofluoride). The molecular structural formula of the derivative is disclosed in the specification, wherein X is F-, Cl-, Br- and I-; and R is CnH2n+1, and n is 1-20. The substance has obvious activity of reducing the blood fat and the blood sugar, and the activity of reducing the blood fat and the blood sugar is obviously higher than that of the coptisine salt, thus the long-chain alkyl coptisine halate derivative is a promising new compound having medicinal values of blood fat reduction, blood sugar reduction, and the like.

The invention discloses a compound fermented traditional Chinese medicine for preventing and treating chicken salmonellosis. The compound fermented traditional Chinese medicine is prepared from the following components in parts by weight: 45-60 parts of Chinese pulsatilla root, 20-40 parts of atractylodes macrocephala, 10-30 parts of coptis, 10-30 parts of phellodendron amurense, 5-15 parts of clove, 5-20 parts of agastache, 40-60 parts of dandelion, 10-30 parts of radix sophorae flavescentis, 2-15 parts of gentian, 10-30 parts of purslane, and 5-20 parts of radix paeoniae alba. The traditional Chinese medicine composition is prepared by the following steps: smashing the components in ultrasound; adding fermented culture medium and compound bacteria liquid; conducting enclosed anerobic fermentation at 36-37 DEG C for 12-14 h; adding a stabilizer in the fermented product; conducting vacuum low-temperature drying. The traditional Chinese medicine composition prepared from microbe fermentation acts with the microbe, is converted into components easy to be ingested and utilized by bodies, accelerates treating speed, improves curative effect, and micro-ecology environment of bodies, improves animal food return rate and performance trait, is used for preventing and treating chicken salmonellosis, can effectively relieve the symptom of diarrhea of chicken, eliminates or remarkably relieves inflammatory pathological injury of gastrointestinal tracts and cloaca, relieves potential safety hazards caused by chemical drugs, and improves safety of pharmacy.

The invention relates to a traditional Chinese medicine extract having poultry and livestock mycoplasma resistant activity. The traditional Chinese medicine extract contains any one or more of the following components: 1-512 mu g / mL of nitidine chloride, 1-512 mu g / mL of ethoxychelerythrine, 1-512 mu g / mL of chelerythrine, 1-512 mu g / mL of sanguinarine, 1-512 mu g / mL of coptisine, 1-512 mu g / mL of palmatine, 1-512 mu g / mL of epiberberine, and 1-512 mu g / mL of glycyrrhetinic acid. The invention further provides a traditional Chinese medicine composition having poultry and livestock mycoplasma resistant activity. Both the traditional Chinese medicine extract and the traditional Chinese medicine composition provided by the invention have the stronger effect for inhibiting poultry and livestock mycoplasma activity in vitro, are safe, green and free from medicine residue, and can be applied to treating and preventing poultry and livestock mycoplasma diseases.

The invention discloses a coptis alkaloid and ferulic acid compound with glucose-lowering effect, which comprises the following components in percentage by weight: 0.1 to 99.9 percent of coptis alkaloid and 0.1 to 99.9 percent of ferulic acid, wherein the coptis alkaloid contains berberine or coptisine or palmatine or jatrorrhizine or the sum of four coptis alkaloids, or is total coptis alkaloids extracted from coptis. The compound has the advantages of better glucose-lowering effect compared with that of the coptis alkaloid or ferulic acid, and obvious glucose-lowering effect according to administration in a dosage of 0.5 to 5 grams every person per day.

The invention relates to an extracting method and an application of high-purity coptisine. The extracting method comprises the following technological processes: taking raw materials (rhizoma coptidis or rhizoma coptidis fibrous roots or rhizoma coptidis ash), crushing the raw materials (if the raw materials are the rhizoma coptidis fibrous roots or rhizoma coptidis ash, a crushing process is not needed), adding 0.1-5% of sulfuric acid for soaking, performing heating extraction for four times, filtering, performing neutralization by virtue of calcium oxide (or calcium hydroxide), filtering and washing precipitates, performing preconcentration, removing impurities from the precipitates, depositing coptisine, performing re-crystallization on coptisine, and drying the precipitates to obtain a coptisine product with the rhizoma coptidis content of more than 90%. The product disclosed by the invention has good effects of reducing blood fat, losing weight, reducing blood sugar and the like, and is the ideal raw material for treating cardiovascular diseases, adiposis and diabetes.

The invention discloses an application of protoberberine alkaloid to prepare anti-drug tolerant bacterial drug, in particular to an application of compound coptisine, dehydrokaweidin and dihydroapokaweidin in the anti-drug tolerant bacterial drug, which is characterized by the following: extracting protoberberine from Corydalis saxicola Bunt. of Corydalis of Papaveraceae; displaying obvious inhibition for MRSA in the clinic through pharmacological test; using the compound protoberberine alkaloid as active component to make the drug to treat anti-drug tolerant bacterial drug.

The present invention pertains to the art of Chinese medicine, in particular to a recipe of an oral ulcer bilayer formulation and a preparation process. The formulation of the present invention includes the following ingredients in share by weight: 25-40 percents of coptis root, 15-25 percents of liquorice, 12-20 percents of radix notoginseng, 12-20 percents of villous amomum fruit, 0.15-0.20 percents of borneol and 8-15 percents of mint. The preparation process is that the villous amomum fruit and mint are extracted to get a naphtha; the residues, coptis root and liquorice are decocted with water; the radix notoginseng is extracted in an alcohol; all the extracted is merged with borneol, mint oil and PVA added, which is made into a single-layer membrane; then an ethyl cellulose is added to form a bilayer. The present invention has the advantages of nourishing yin and lowering fire, invigorating blood circulation and eliminating stasis, promoting granulation and relieving pain, safety and reliability, convenient use and high curative effect, which can be widely promoted and applied.

The invention discloses application of neuraminidase and neuraminidase inhibitors to preparation of medicines for inhibiting hepatic gluconeogenesis. Zanamivir and oseltamivir phosphate are effectiveinhibitors of the neuraminidase; the inhibition effect of coptisine on neuraminidase is also disclosed in the previous patent application of the applicant. The applicant also discovers that salvanic acid B is capable of inhibiting the activity of the neuraminidase in vitro and is used as an inhibitor of the neuraminidase. In-vivo test proves that the several neuraminidase inhibitors are capable ofeffectively inhibiting the activity of the neuraminidase in the liver and then inhibiting hepatic gluconeogenesis. Therefore, the neuraminidase and the neuraminidase inhibitors can be used for preparing the medicines for inhibiting hepatic gluconeogenesis and can also be used for treating diabetes, obesity and non-alcoholic fatty liver disease.

The invention discloses a compound traditional Chinese medicine extract preventing glucose metabolism disturbance, comprising the following effective ingredients: dried alcohol, Beta-sitosterol, hexacosanoic acid, butenolide III, oleanolic acid, berberine, jateorhizine, coptisine, salvianic acid A, salvianolic acid B, ring-tetracosane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin, specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1 and encommiol. A preparation method of the extract is as follows: extracting raw material medicines by C1-3 alcohol and / or water, combining a total extract, extracting the total extract by organic solvents with different polarities so as to obtain all effective ingredients, and finally mixing the ingredients so as to obtain a product. As for the compound traditional Chinese medicine extract, a large number of ineffective chemical ingredients in Chinese medicine are removed, so that the content of effective ingredients is increased greatly, and the influence on product processing and preparation quality caused by the ineffective ingredients is reduced; and simultaneously, the preparation process is stable, the product quality is controllable, the mass production is facilitated, and the drug effect of the compound traditional Chinese medicine is improved.

The invention relates to a medicinal preparation for treating burn and scald, which is a preferred externally applied agent for treating various levels of burn and scald. The medicinal preparation isprepared from the following raw materials in portion by weight: 0.5 to 2 portions of golden thread, 0.5 to 2 portions of weeping forsythiae capsule, 0.8 to 2 portions of amur corktree bark, 1 to 2 portions of charred sanguisorba, 0.5 to 1 portion of carbonized human hair, 1 to 2 portions of cochinchnese asparagus root, 1 to 2 portions of mongolian snakegourd root, 1 to 2 portions of dahurian angelica root, 0.5 to 1 portions of lightyellow sophora root, 1 to 1.5 portions of liquoric root, 1 to 3 portions of common andrographis herb, 0.5 to 0.8 portion of tree peony bark, 0.5 to 0.8 portion of sinkiang arnebia root, 0.5 to 0.8 portion of safflower, 0.5 to 0.8 portion of borneol and 30 to 65 portions of sesame oil. The medicinal preparation has quick response to inflammation and pain of the wound surface of the burn and scald, obviously relives the pain of a patient after the preparation is applied for more than ten minutes, can kill a predominant pathogen causing infection, namely gram negative bacterium, and can form a layer of protecting film on the wound surface to effectively prevent or control the infection and cross infection of the wound surface.

The invention discloses a pharmaceutical composition for treating diabetes mellitus in earlier stage. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 5-15 parts of epiberberine, 10-20 parts of coptisine, 15-25 parts of palmatine, 20-35 parts of berberine, 10-15 parts of astragaloside, 0-10 parts of astragalus saponin II, 0-15 parts of astragalus saponin III, 0-10 parts of astragalus saponin I, 20-30 parts of calycosin-7-glucoside, 0-20 parts of formononetin and 0-18 parts of ononin. The pharmaceutical composition provides a new choice for the treatment of the diabetes mellitus in the earlier stage, changes the status quo of the lack of effective prevention and treatment medicines of the diabetes mellitus in the earlier stage, can significantly improve the clinical symptoms of the diabetes mellitus in the earlier stage, significantly reduces blood glucose and glycosylated hemoglobin levels, regulates glucose metabolism, and significantly prevents or delays the progress of the diabetes mellitus in the earlier stage.