25 results about "Butenolide" patented technology

The invention discloses a method for preparing a chiral furanone ester derivative, which comprises the following steps: adding a metal catalyst into a solvent, sequentially adding a carboxylic acid compound I or a carboxylic acid compound II and a butene lactone compound III, introducing inert gas, stirring, post-treating and purifying to obtain a chiral furanone ester compound IV; the palladium catalysis system is composed of palladium salt and a chiral ligand V, and the chiral ligand has a structure shown in a formula V.

The invention belongs to the technical field of functional paint, and particularly relates to antifouling paint for ships and a preparation method of the antifouling paint. The invention aims to solve the problem that the existing ship antifouling paint is difficult to give consideration to both broad-spectrum antifouling effect and environmental safety. The preparation method comprises the following steps: carrying out chain extension polymerization on polycaprolactone polyol and polydimethylsiloxane glycol to obtain a block copolymer; the preparation method comprises the following steps: emulsifying and curing butenolide and polycaprolactone glycol to obtain an antifouling microcapsule, and further carrying out self-assembly crosslinking to obtain a response microcapsule; mixing the dispersing aid, the compound solvent and the functional filler to obtain a compound aid; mixing the dispersing aid, the compound solvent and the functional filler to obtain a compound aid; and performing phase separation and curing on the antifouling paint to obtain the antifouling coating. The anti-fouling paint prepared by the preparation method disclosed by the invention has a remarkable inhibition effect on attachment of fouling organisms while having good aging resistance and corrosion resistance, and is high in environmental safety.

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

The invention discloses an antifouling waterborne polyurethane material for ships and a preparation method thereof.The preparation method comprises the steps that polyester polyol and polyether polyol which are subjected to vacuum dehydration, diisocyanate, a catalyst and a chain extender are heated to 65-85 DEG C, a prepolymerization reaction is conducted, and a polyurethane prepolymer is obtained; adding sulphobetaine into the polyurethane prepolymer, and reacting at the temperature of 50 DEG C to obtain a modified polyurethane prepolymer; adding a butenolide emulsion, a stabilizer, a blocking agent and a defoaming agent into the modified polyurethane prepolymer, adjusting the pH value to 6-7, and stirring and mixing to obtain a butenolide-modified polyurethane prepolymer composite material; and adding a plasticizer and a reinforcing agent into the butenolide-modified polyurethane prepolymer composite material, and stirring for reaction to obtain the antifouling waterborne polyurethane material. Therefore, the waterborne polyurethane material has the functions of resisting bacteria and expelling marine attaching organisms, and the antifouling property of the waterborne polyurethane material is improved.

The application provides a fusariobutenolide derivative 4''-O-isopentenyl fusariobutenolide C, and a structural formula of the compound is provided.The 4''-O-isopentenyl fusariobutenolide C can significantly inhibit the growth of seven human routine pathogenic bacteria in antibacterial activity testing, and the MIC is 8.6-28.3 μg / mL, and the antibacterial effect on one strain of human drug-resistant pathogenic bacteria, methicillin-resistant Staphylococcus aureus, is significant, and the MIC is 16.8 μg / mL, and the 4''-O-isopentenyl fusariobutenolide C can be applied to preparation of antibacterial drug precursors, and lays a material foundation for next-step biological medicine development and application of antibacterial components.

A radiation curable coating composition comprising: a) one or more butenolide monomers A of general formula (I) wherein n is 0 or an integer from 1 to 5; r1 is alkyl or aryl; x is any one of-C (O)-,-C (O) O-,-C (O) NR2-,-S (O)-,-S (O2)-,-C (O) S-,-C (S) S-, and-C (S) NR2-; wherein R2 is hydrogen, alkyl or aryl; or wherein when n is 0 and X is-C (O) NR2-or-C (S) NR2-, R1 and R2 together with the nitrogen atom through which they are attached form a nitrogen-containing heterocyclic group or nitrogen-containing heteroaryl group; and b) one or more vinyl monomers B comprising one or more vinyl groups, wherein at least one vinyl group has a 13C chemical shift difference between alpha-C and beta-C of the vinyl group of at least 25 ppm; wherein at least one monomer of A and B comprises at least two vinyl groups; and coating the substrate. # imgabs0 #

The invention relates to a curable composition comprising one or more copolymer A formed by copolymerization of a monomer mixture, the monomer mixture comprising one or more monomers from the class of butenolides, and one or more vinyl functional monomers; and one or more polyamine substances B, the polyamine substance(s) B comprising at least two primary amino groups. The Invention further relates to the cured composition obtained from the curable composition, and the compositions as part of coated substrates and stacks of substrates. The invention further relates to a copolymer A used in the compositions and its method of manufacture, as well as the use of the curable composition as coating material, sealant material or adhesive material.

The application discloses a heterocycle-substituted gamma, delta-unsaturated butenolide in the field of organic synthesis technology, and a structural formula is as follows: wherein the heterocycle skeleton can independently represent a benzopentazacyclic nitrogen heterocycle skeleton, a benzohexazacyclic nitrogen heterocycle skeleton, a benzopentazacyclic oxygen heterocycle skeleton, a benzohexazacyclic oxygen heterocycle skeleton or a fused heterocycle skeleton. Research finds that the compound has the activities of resisting leukemia, lung cancer, liver cancer, breast cancer and colon cancer.

The application discloses a novel butenolide signal molecule and application thereof in gene expression regulation. The application provides a novel butenolide signal molecule SFB1, and the structure is shown as formula I). The inducible gene expression regulation circuit composed of the SFB1, a receptor protein and a hybrid promoter can work efficiently in Escherichia coli, that is, nanomolar concentration of the signal molecule SFB1 can effectively remove the repression of the hybrid promoter by the receptor protein TylP, and induce the expression of a target gene; other types of streptomyces signal molecules including butenolide and gamma-butyrolactone from other streptomyces cannot significantly remove the repression of the hybrid promoter by the TylP, that is, the regulation circuit of the application is not interfered by other common types of signal molecules in streptomyces, and can be combined with existing AHL or GBL type regulation tools, so that the synthetic biology tool library is enriched.

The present application belongs to the technical field of functional coating, and particularly relates to a kind of marine antifouling coating and its preparation method.The present application aims to solve the problem that the existing marine antifouling coating is difficult to consider the broad-spectrum antifouling effect and environmental safety.The present application polymerizes block copolymer by chain extension of polycaprolactone polyol and polydimethylsiloxane diol;Antifouling microcapsules are obtained by emulsification and curing of butenolide and polycaprolactone diol, and further obtained by self-assembly crosslinking;Composite additives are obtained by mixing dispersing aids, complex solvents and functional fillers;Composite additives are obtained by mixing dispersing aids, complex solvents and functional fillers;Antifouling coating is obtained by phase separation and curing of antifouling coating.The antifouling coating prepared by the present application has good aging resistance and corrosion resistance, and has significant inhibitory effect on the attachment of fouling organisms, and high environmental safety.

The application discloses a butenolide compound from a marine fungus, a preparation method and application thereof, and has the advantages that the butenolide compound is a novel compound discovered from metabolic products of Aspergillus terreus, similar skeleton compounds have not been reported, and the application proves for the first time that the butenolide compound has better tumor cell proliferation inhibition ability on colon cancer cells compared with other butenolide compounds.

The invention discloses a flavin-dependent oxidase SavA and an application of the flavin-dependent oxidase SavA in asymmetric synthesis of 4-alkyl butenolactone. The SavA enzyme provided by the invention is a novel multifunctional enzyme with desaturation, hydroxylation and lactonization effects at the same time, and can catalyze conversion of fatty acyl thioester into single-configuration (4S)-4-alkyl butene lactone. The SavA enzyme provided by the invention is a flavin-dependent enzyme and naturally exists in a form of being combined with FAD, no exogenous FAD needs to be added in an in-vitro enzymatic reaction, no other coenzyme or cofactor is involved, only O2 is used as an oxidizing agent, the reaction process is green and efficient, and the SavA enzyme has the potential of being developed into an efficient tool enzyme for asymmetric biological catalytic synthesis of 4-substituted butenolactone.

The invention discloses a preparation method of heterocycle-substituted gamma, delta-unsaturated butene lactone in the technical field of organic synthesis, and the synthesis route is as follows: # imgabs0 #: step 1, sequentially adding a metal palladium catalyst, a phosphine ligand, alkali, cyclopropenone and different iodobenzene-substituted olefins, then adding an organic solvent to obtain a mixture, and reacting for 2-4 hours; stirring the mixture at a certain reaction temperature under the protection of inert gas; and 2, after the reaction is finished, carrying out post-treatment separation to obtain the corresponding heterocycle substituted gamma, delta-unsaturated butene lactone. Researches find that the compound has the activity of resisting leukemia, lung cancer, liver cancer, breast cancer and colon cancer.

The invention discloses a cinnamic acid butenolide compound and a preparation method and application thereof.The cinnamic acid butenolide compound has the advantages of being environmentally friendly and low in toxicity, shows excellent performance in the field of insect killing and sterilization, can be widely applied to the scenes of agricultural pest control, forestry insect prevention, daily chemical antibiosis and the like, and has a wide application prospect. The compound disclosed by the invention can be used for remarkably inhibiting strawberry botrytis cinerea and colletotrichum gloeosporioides, the highest inhibition rate reaches 78%, in addition, the compound has a super-strong inhibition effect on alfalfa aphids, the inhibition rate of most compounds reaches 80% or above, the highest inhibition rate reaches 95%, and the compound has an important application value in the fields of agricultural chemistry and biological control. Besides, the preparation method is simple to operate and easy to realize through a commercialized cinnamic acid compound, does not need intermediate separation and purification, can directly and quickly synthesize a target product, and has the advantages of environmental friendliness, low toxicity, high yield, simple steps, mild conditions, wide substrate application range, simple post-treatment and the like.

The invention discloses a preparation method of a cyclic 1, 2-oxaacid ester derivative, and belongs to the technical field of organic synthesis. It is found for the first time that NaHMDS serving as alkali can promote activation of a borohydride reagent, trans-addition of propargyl alcohol is achieved, and five-membered ring 1, 2-oxaboric acid can be constructed in one step. The method has the advantages of mild reaction conditions, wide substrate range, strong functional group tolerance and specific regioselectivity. In addition, the cyclic 1, 2-oxaboric acid is also a bioisostere of a butenolactone structure, and is expected to have considerable biological activity.

The invention relates to a binder polymer obtainable by copolymerizing a monomer mixture comprising a vinyl monomer M1 and a butenolide monomer M2, wherein the vinyl monomer M1 is a vinyl ether, a vinyl ester, or a combination thereof, and the butenolide monomer M2 is a 5-alkoxy-2(5H)-furanone. The invention further relates to a coating composition comprising such binder polymer and to a substrate coated with a coating deposited from such coating composition.

The invention belongs to the technical field of biological medicines, and discloses application of a deep-sea butyrolactone compound in preparation of a medicine for preventing and / or treating inflammatory bowel diseases. The butyrolactone compound disclosed by the invention is specifically 5-acetyl-3-hydroxy-4-(4-hydroxyphenyl)-5-[4-methyl-3-(3-methylbutyl-2-ene-1-yl) benzyl] furan-2 (5H)-ketone, and the structural formula of the butyrolactone compound is shown in the description. It is proved for the first time that the butyrolactone compound has the activity of remarkably improving the inflammatory bowel disease, the body weight, defecation, intestinal length and intestinal weight of a mouse with the inflammatory bowel disease induced by DSS are remarkably improved, and the effect of the butyrolactone compound is superior to that of a positive drug salazosulfapyridine (SASP). The invention provides the application of the butyrolactone compound or the derivative thereof or the pharmaceutically acceptable salt thereof in preparing the medicine for preventing and / or treating the inflammatory bowel disease, and provides a new medicine for treating the inflammatory bowel disease, so that the butyrolactone compound has a wide application prospect.

A radiation-curable coating composition, comprising a monomer mixture comprising: a) at least one butenolide monomer A, which butenolide monomer is a substituted-5-hydroxy-2(5H)-furanone of general formula (I) wherein: n is 0 or an integer of from 1 to 5; m is 0 or 1; R1 is alkyl or aryl; X is any one of —C(O)—, —C(O)O—, —C(O)NR2—, —S(O)—, —S(O2)—, —C(O)S—, —C(S)S— and —C(S)NR2—; wherein R2 is hydrogen, alkyl or aryl; and b) at least one N-vinyl monomer B, which N-vinyl monomer is a compound of general formula (II) wherein R4 and R5 are each independently any one of hydrogen, alkyl, aryl, heteroalkyl or heteroaryl and Y is selected from O, NR6 and S; and wherein either: i) a is 1 and b is 1; or ii) a is 0 and b is 2; and wherein at least one monomer of A and B comprises at least two vinyl groups.

The application discloses a kind of brominated gamma-aryl butenolide compounds and preparation method and application thereof, first from marine-derived microorganism isolation obtain series brominated gamma-aryl butenolide compounds, to five kinds of agricultural economic crops pathogenic bacteria: Colletotrichum gloeosporioides, olive fruit rot fungus Pestalotiopsis microspora, banana wilt fungus Panama disease, Botrytis cinerea and oil gan black rot fungus Diaporthephoenicicola have good antibacterial effect, and to clinical first-line tumor drug camptothecin, etoposide drug resistance enzyme TDP1 and TDP2 have significant inhibitory effect, provide pharmacodynamic material basis for subsequent fruit and vegetable agricultural fungi antibacterial research, and provide solid experimental data for widening the application of marine drug source molecule.

The invention discloses an application of biocontrol bacillus subtilis and a bactericide compound WML-01 in the prevention and treatment of soybean root rot by mixing the biocontrol bacillus subtilis and the bactericide compound WML-01 in a barrel. The biocontrol bacillus subtilis is bacillus subtilis (Bacillus subtilis) LH-01 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.36506. The bactericide WML-01 is a butylenolide compound containing a thiazolidone structure, has a wide bactericidal spectrum, and does not have cross resistance with currently common bactericide types. According to the invention, the microbial agent and the bactericide WML-01 are mixed in a barrel for use, so that the soybean root rot caused by fusarium, pythium, phytophthora sojae and rhizoctonia solani can be effectively prevented and treated, a more excellent prevention effect on the soybean root rot is shown, the use amount of chemical pesticides is reduced, more methods are provided for preventing and treating diseases by mixed use of fungus-pesticide barrels, and the method is worthy of popularization and application. Wide market application prospects are realized.

The invention relates to a coating composition comprising a binder polymer which can be obtained by copolymerizing a monomer mixture comprising a vinyl monomer M1 and a butenolide monomer M2, the vinyl monomer M1 having a 13C chemical shift difference between alpha-C and beta-C of the vinyl group of at least 25 ppm, and wherein the butenolide monomer M2 is a substituted 5-hydroxy-2 (5H)-furanone of general formula (I) wherein R1 is any one of-C (O) R2,-C (O) OR2,-C (O) NR2R3,-S (O) R2,-S (O2) R2,-C (O) SR2,-C (S) SR2 and-C (S) NR2R3 wherein R2 is an alkyl or aryl group, and wherein R3 is hydrogen, alkyl or aryl group, or wherein R2 and R3 together with the nitrogen atom through which they are attached form a nitrogen-containing cyclic heteroalkyl or nitrogen-containing heteroaryl group. The invention further relates to a substrate coated with a coating deposited from the coating composition, a binder polymer and a novel butenolide monomer M2. # imgabs0 #

A radiation curable coating composition comprising a monomer mixture comprising: a) at least one butenolide monomer A which is a substituted 5-hydroxy-2 (5H)-furanone of general formula (I) wherein n is 0 or an integer from 1 to 5; m is 0 or 1; r1 is alkyl or aryl; x is any one of-C (O)-,-C (O) O-,-C (O) NR2-,-S (O)-,-S (O2)-,-C (O) S-,-C (S) S-, and-C (S) NR2-; wherein R2 is hydrogen, alkyl or aryl; and b) at least one N-vinyl monomer B which is a compound of general formula (II) wherein R4 and R5 are each independently any of hydrogen, alkyl, aryl, heteroalkyl or heteroaryl and Y is selected from O, NR6 and S; and wherein i) a is 1 and b is 1; or ii) a is 0 and b is 2; and wherein at least one of the monomers of A and B comprises at least two vinyl groups. # imgabs0 #

The invention discloses a preparation method of a polysubstituted butene lactone compound, which comprises the following step: by taking cyclopropenone and amide as initial raw materials and trimethylphosphine as a catalyst, carrying out [3 + 2] cycloaddition reaction under the conditions of no water, no oxygen and room temperature to generate the polysubstituted butene lactone compound. The generated polysubstituted butene lactone compounds are new compounds, have certain potential pharmaceutical activity, and can be further converted into functionalized products. The reaction raw materials are easy to obtain, the reaction conditions are mild, the method has the characteristics of no metal and environmental protection, and the functional groups are diversified.

The application provides a compound with plant growth regulation effect and a preparation method and application thereof. White peony alkaloids G and H are isolated and identified from traditional Chinese medicine white peony for the first time; the structure is novel; a butenolide structure which is same as that in a plant signal molecule strigolactone, trimethyl butenolide and the like is contained in the parent nucleus structure; however, the natural content of the two white peony alkaloids is extremely low, so the white peony alkaloids G and H are synthesized by using a chemical method, and a derivative is obtained. Research finds that the white peony alkaloids and the derivative of the application exhibit a significant promoting effect on the germination of dicotyledonous crop seeds and monocotyledonous crop seeds at a low concentration, and exhibit an inhibiting effect at a high concentration. It is indicated that the white peony alkaloids and the derivative above can be a new plant hormone-like molecule, and can play a regulation effect on the growth of plants.

The invention provides a butenolide compound as well as a preparation method and application thereof, the compound has high biological inhibition activity as an antifouling agent and has a certain inhibition effect on gram-positive bacteria and gram-negative bacteria, and the minimum inhibitory concentrations of the compound on staphylococcus aureus and escherichia coli are 0.125 mg / mL and 0.25 mg / mL respectively. According to the preparation method, phenylalanine and pyruvic acid react to prepare phenylalanine, so that the preparation method has the characteristics of simple steps, easily available raw materials and mild conditions, and can be suitable for large-scale industrial production. According to the present invention, the structure and the anti-fouling mechanism of the compound are deeply studied, and when the compound is adopted as the active component of the anti-fouling agent and the concentration is 8.0 mg / L, the sterilization rate on escherichia coli can achieve 99.99%, and the excellent sterilization performance is provided, such that the gamma-hydroxybutenolide compound has potential application value in the field of the environment-friendly marine anti-fouling coating material as the anti-fouling agent.