78 results about "Butenolide" patented technology

The invention discloses a composite fiber macromolecular reinforced concrete sound barrier and a manufacturing method thereof. Concrete raw materials comprise ceramsite, sand, gel materials, reinforcing fibers, a water reducing agent, polymer emulsion and water. The gel materials comprise cement, coal ash, silicon ash and mineral powder. The reinforcing fibers are steel fibers and/or polypropylene fibers. The polymer emulsion is acrylate copolymer emulsion or butenolide copolymer emulsion. According to the manufacturing method, the ceramsite is pre-soaked, and after the other raw materials are added in sequence and stirred, pouring, grout collecting, plastering and hardening are performed. Through the combination of lightweight aggregate, sound absorption materials, organic fibers, inorganic fibers, macromolecular reinforcing agents and other materials in the formula, the composite fiber macromolecular reinforced concrete sound barrier is light in weight, good in mechanical property, good in sound absorption and insulation effect, low in cost, good in durability and environmentally friendly.

The invention discloses a use of butenolide I for preparing drugs for controlling immunological liver injury. With the present invention, the butenolide I can reduce levels of TNF-alpha and NO, wherein the TNF-alpha and the NO play important roles in a pathogenic process of the immunological liver injury; the butenolide I can reduce elevated levels of the NO and the iNOS in liver homogenates of immunological liver injury mice so as to decrease the liver injury induced by the NO; the butenolide I can inhibit a overexpression of the TNF-alpha so as to decrease the direct liver injury or the indirect liver injury induced by the TNF-alpha. In addition, the use of the butenolide I as the drug for controlling the immunological liver injury has advantages of convenient preparation, extensive sources, low price and high safety, and has good development and application prospect.

The invention discloses a method for separating effective component, atractylenolide II, from Rhizoma Atractylodis Macrocephalae volatile oil. The method includes pulverizing rhizome of dried Rhizoma Atractylodis Macrocephalae, extracting in medium and low polar solvents, and concentrating to obtain tan volatile oil; standing for a certain time, extracting the volatile oil with mixed solution prepared from n-hexane, ethyl acetate, ethanol and water at a certain ratio, collecting upper layer phase, and concentrating to obtain the refined volatile oil; and gradient eluting with mixed solvent of petroleum ether and ethyl acetate at a certain ratio with column chromatography, collecting correspondent fraction, concentrating, and recycling solvent to obtain atractylenolide II. The method performs pretreatment on Rhizoma Atractylodis Macrocephalae volatile oil coarse product by extracting and oxidizing before separating through column chromatography to have simple process and low cost, increased yield and purity of atractylenolide II, and avoids the disadvantages in the conventional post-treatment steps such as crystal loss caused by recrystallization, etc.

The invention relates to the technical field of organic chemistry and particularly relates to a synthesis method for a spirally-epoxidized indole butenolide compound which is shown as the formula IV. The method comprises takes alkynal shown as the formula I and N-methyl isatin shown as the formula II as raw materials, and takes dioxane as a solvent in the presence of a triazole salt shown as the formula III, lithium chloride and diisopropyl ethyl amine to react for 3-72 hours under the condition of nitrogen protection and at 10-65 DEG C; a reaction solution is cooled and concentrated and a mixed solvent of a petroleum ether and acetone in the volume ratio of 25:1 is used as an eluting agent to carry out column chromatography elution; detected eluting solution parts of all products are collected and rotary evaporation is carried out so as to remove the solvent to obtain a spirally-epoxidized indole butenolide product. The synthesis method provided by the invention has good yield, and the application range of primers is wide; the synthesis method has the advantages of simplicity and convenience for operation, moderate reaction, convenience for post-treatment and the like.

The invention discloses an application of a class of a butenolide compounds in the preparation of a marine biofouling prevention coating material. The butyrol actone V, the aspernolide A, the butyrolactone IV, the aspernolide B, the butyrolactone II, the 4-(4-Hydroxyphenyl)-5-(4-hydroxypheneylmethyl)-2-hydroxyfurane-2-one, the 5,6-dihydropenicillic acid and the 5,6-dihydro-6-hydroxy-penicillic acid, which are provided by the invention, have marine biofouling prevention activity and can be used for preparing the marine biofouling prevention coating material; if the compounds permeate or diffuse into film forming natural resin, polyethylene ethyl acetate copolymer and other polymers such as hydrolyzable, soluble or insoluble resin in an independent or combined way to prepare the marine biofouling prevention coating material, the marine biofouling prevention coating material can release sufficient effective components to a surface to achieve an antifouling function; as the compounds are natural active ingredients, are hard to dissolve in water but easy to dissolve organic solvents such as chloroform, ethyl acetate and methyl alcohol, and have favorable oleophilic properties, the components can be applied to preparing the marine antifouling agents in an independent or combined way and have a favorable application prospect.

The invention discloses butenolide structure-containing benzyl amino dithio formiate compounds, and a preparation method and application thereof, and belongs to the field of medicinal chemistry. The structure is shown as the general formula I, wherein R1 is C1-C5 alkyl or hydrogen; R2 is C1-C5 alkyl or hydrogen; and R3 is hydrogen, methyl monosubstituted or multisubstituted at different positions, methoxy, fluorine, chlorine or hydroxyl and the like. The preparation method comprises the following steps of: adding a CS2 solution into benzylamine or substituted benzylamine and an aqueous solution of alkaline substances dropwise; stirring; adding 3-bromomethyl-gamma-butyrolactone; reacting with stirring; and performing recrystallization or column chromatography separation to prepare the butenolide structure-containing benzyl amino dithio formiate compounds. The butenolide structure-containing benzyl amino dithio formiate compounds have obvious inhibition effect on fungi such as candida albicans, grayish purple penicillium, aspergillus niger and the like, and have important significance for further researching novel antifungal medicaments and developing medicaments with proprietary intellectual property rights.

The invention discloses a petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance, comprising the following active components: isoceryl alcohol, beta-sitosterol, n-hexacosane acid, butenolide III, oleanolic acid, berberine, jateorhizine, salvianolic acid B, lignocerane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin and ginsenoside Rb1. The preparation method comprises the following steps: after extracting crude medicines of root of red rooted salvia, glossy privet fruit, coptis, thistle, eucommia, white atractylodes rhizome, pseudo-ginseng and finger citron by C1-3 alcohols and/or water, combining all the extracts, and extracting the total extract by petroleum ether to obtain the petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance. A big amount of inactive components in the original compound traditional Chinese medicine are removed from the extract provided by the invention, so that much more efficient extraction parts of the traditional Chinese medicines are obtained, and the extract has a stable preparation process, controllable quality and notable curative effect, and is convenient to use and be produced into various dosage forms.

The invention relates to a green synthetic method of hydroxyl butenolide and congeners thereof, and the synthetic method is especially suitable for one-step method preparation of hydroxyl butenolide from chemical raw materials like furfural and furoic acid. A routine dyeing technology is employed to load a photosensitizer on renewable natural fiber to obtain a green photosensitizer; in the presence of light, reaction raw materials react with oxygen to prepare hydroxyl butenolide through the one-step method. The method provided by the invention eliminates the problem that photosensitizer and products are difficult to separate, and that the photosensitizer can not be reused; and the method also solves the problem that although a high-molecular polymer loaded photosensitizer can be reused, the carrier raw material is non-renewable and causes environmental pollution for wasting. The method provided by the invention has the advantages of reaction under room temperature, relax temperature control and simple post-treatment steps, substantially increases product yield and is in favor of development and industrialization of green chemistry technology in hydroxyl butenolide synthesis technology.

Methods and materials for preparing 4-substituted-2-buten-4-olides are disclosed. The methods include reacting a masked mucohalic acid with a primary or secondary amine or with an arylol in the presence of a base. Unlike existing processes, the disclosed methods do not require the use of palladium, which make them well suited for preparing intermediates in drug syntheses.

The present invention relates to a gamma-butenolide whose four positions contain aryl substituent and its solid phase synthesis method. Said invention provides the structure formula of said compound.

The invention discloses a compound traditional Chinese medicine extract preventing glucose metabolism disturbance, comprising the following effective ingredients: dried alcohol, Beta-sitosterol, hexacosanoic acid, butenolide III, oleanolic acid, berberine, jateorhizine, coptisine, salvianic acid A, salvianolic acid B, ring-tetracosane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin, specnuezhenide, ginsenoside Rb1 and Rg1, notoginsenoside R1 and encommiol. A preparation method of the extract is as follows: extracting raw material medicines by C1-3 alcohol and/or water, combining a total extract, extracting the total extract by organic solvents with different polarities so as to obtain all effective ingredients, and finally mixing the ingredients so as to obtain a product. As for the compound traditional Chinese medicine extract, a large number of ineffective chemical ingredients in Chinese medicine are removed, so that the content of effective ingredients is increased greatly, and the influence on product processing and preparation quality caused by the ineffective ingredients is reduced; and simultaneously, the preparation process is stable, the product quality is controllable, the mass production is facilitated, and the drug effect of the compound traditional Chinese medicine is improved.

The invention discloses a method of preparing r-butenolide from alkenyl epoxide. The method includes taking the MBH type alkenyl epoxide as a raw material, and allowing a reaction between the MBH type alkenyl epoxide and nucleophile to obtain the r-butenolide at the room temperature. The method has the advantages of mild reaction condition, non-use of metal catalysts, and high efficiency and speed under room temperature.

The invention discloses an asymmetric synthesis method of a gamma-alkenyl substituted butenolide or butenolactam compound. The method adopts cheap nickel to catalyze a [3+2] asymmetric cycloaddition reaction of a cyclopropenone compound and alpha, beta-unsaturated ketone or imine, the selective insertion reaction of intermolecular C=X after nickel-catalyzed C-C bond activation is realized for thefirst time, wherein X is equal to O or N, the gamma-alkenyl substituted butenolide or butenolactam compound is obtained in a high yield, high enantioselectivity and chirality controllable manner, thesynthesis method is novel, condition mildness, substrate with good applicability, simple and efficient reaction, cheap and readily available catalyst, according to the present invention, the synthesisprocess is simple, the atom economy is good, the synthesis product is easy to derivatize, the method can be widely used in completely-synthesized designed synthesis building blocks and new chiral drug derivatives, and the ligand compound is further provided, and can be used for the asymmetric synthesis of gamma-alkenyl substituted butenolide or butenolactam compounds.

This invention involves a synthetic method to a kind of beta-iodo-butenolide and its synthesizing method in which synthesizes-beta-Iodo-butenolide through the iodolactonization of 2, 3- joint alkene diethylene glycol dinitrate with iodine in the water-organic agents mixed solvent. At room temperature, in mixing solvent of water and organic agent, iodine takes cyclization with 2,3-allenic ester, receive beta-Iodo-butenolide. This method has advantage of mild reacting condition, short response time, high producing rate, low costs and easy industrialization.

The invention discloses a process for separating effective component of butenolide III from lagehead atractylodes volatile oil, which comprises leaching the disintegrated lagehead atractylodes with medium polar solvent, reclaiming the solvent to obtain chartreuse green volatile oil, dissolving the volatile oil with low carbon chain and storing at -4 to 0 deg C, removing insoluble substances, concentrating the filtrate to obtain refined volatile oil, dissolving the volatile oil with medium polar solvent, then gradually charging low polar solvent, removing precipitation, concentrating the filter liquor and degreasing with low polar solvent, finally carrying out recrystallization.

The invention relates to the field of pesticide chemistry, and discloses a 2-butenolide acetamide compound, and a preparation method and an application thereof. The compound has a structure represented by a formula (1). A synthesis method of a compound represented by the formula (2) comprises the steps: carrying out a first reaction on a compound represented by a formula (3) and a compound represented by a formula (4) in the presence of a first alkaline substance and a first solvent. The synthesis method of the compound represented by the formula (1) comprises the steps: carrying out a secondreaction on the compound represented by the formula (2) and a compound represented by a formula (5) in the presence of a second alkaline substance and a second solvent. The 2-butenolide acetamide compound disclosed by the invention can promote germination of root parasitic weed seeds, has relatively high stability, and can be well applied to prevention and treatment of root parasitic weeds in fields.

The invention belongs to the technical field of medicine, and discloses a quality control method for detecting content of butenolide I, butenolide II and 23-acetyl alisol B in a rhizoma alismatis-largehead atractylodes rhizome tablet. The content of one or more components is determined simultaneously or separately by high performance liquid chromatography. C8 and C18 are used as fillers. Isocraticelution or gradient elution is carried out by using 0-100% acetonitrile or methanol as a mobile phase A and 100-0% ultrapure water or glacial acetic acid or a phosphoric acid solution as a mobile phase B. A flow rate is 0.1-2 ml/min, detection wavelength is 203-320 nm, and column temperature is 20-40 DEG C. The method of the invention controls the quality of active components of two medicinal materials in the prescription of the rhizoma alismatis-largehead atractylodes rhizome tablet, and so the quality control of the preparation is more comprehensive, accurate and effective, thereby helpingto ensure the medicine safety and validity. Moreover, the determination method has the advantages of simple operation, accurate result and good precision, stability and reproducibility, is an advancedquality control method and facilitates the standardized production of the medicine.

The invention discloses a desloratadine derivative containing gamma-subunit butenolide and a synthesizing method thereof, and belongs to the technical field of organic chemical synthesis. The compounds by using desloratadine as a raw material medicament have the following structural general formula, namely the most synthesized compounds have good inhibiting effect on the shrinkage of histamine-induced isolated ileum smooth muscles of guinea pigs, and the synthesis of the derivative enriches the structural type of anti-histamine medicaments and widens the research fields of the anti-histamine medicaments. The synthesizing method provides a good foundation for the further development and utilization of medicinal molecules, and has important meanings for further developing novel anti-allergic medicaments and developing the medicaments with proprietary intellectual property rights.

The invention relates to a butenolide metabolite and an application thereof, and belongs to the technical field of microbial pesticides. The production bacterial strain is Streptomyces YIM120811(Streptomycessp.YIM120811) derived from soil and is preserved in typical culture preservation center in China on 19th, September 2013; the preservation number is CCTCCNo:AA2013014. The bacterial strain YIM20811 is subjected to fermenting culture and extracting separation so that two new butenolide compounds A and B are obtained. An antibacterial activity test proves that a butenolide derivative has obvious plant pathogenic fungi activity resistance and has a potential use of preparing a new agricultural antibacterial agent.

The invention discloses a chiral gamma, gamma-disubstituted butenolide compound and a preparation method thereof. Chiral gamma, gamma-disubstituted butenolide compounds widely exist in various naturalproducts, have important biological activity, and are also important intermediates for constructing polyterpene compounds and medicines. According to the application, a series of chiral gamma, gamma-disubstituted butenolide compounds with the yield as high as 98% and the stereoselectivity greater than 20: 1dr and 99% ee are synthesized through a vinylogous Michael addition reaction of gamma-dimerfuranone catalyzed by a bifunctional thiourea catalyst and alpha, beta-unsaturated nitroolefin. According to the method, the functional gamma, gamma-disubstituted butenolide compound with multiple chiral centers can be conveniently, quickly and efficiently obtained.

The invention discloses an aroma butenolide dimer, a preparation method thereof and an application of the aroma butenolide dimer to a COX-2 inhibitor and an oxidation resisting medicine. A compound having COX-2 restraining activity and antioxidant activity is obtained by separation from a fermented product of Aspergillus terreus SCAU011 CGMCC No:19270 (as shown in Fig.1), and the aroma butenolidedimer has favorable application prospects in the respect of preparing the COX-2 inhibitor and the oxidation resisting medicine.