11 results about "Butenolide" patented technology

The present application relates to the technical field of agricultural chemistry, in particular to butenolide compounds containing a thiazolidinone structure as well as a preparation method therefor and the use thereof. The butenolide compounds containing a thiazolidinone structure are characterized by having the following structural general formula (I). The compounds disclosed by the present application have excellent fungicidal activity on various pathogens in agriculture or other fields, and can favorably protect important crops and domestic animals in agriculture and horticulture industry, and the environment that the human beings rely on from invasion of pathogens.

The application provides a fusariobutenolide derivative 4''-O-isopentenyl fusariobutenolide C, and a structural formula of the compound is provided.The 4''-O-isopentenyl fusariobutenolide C can significantly inhibit the growth of seven human routine pathogenic bacteria in antibacterial activity testing, and the MIC is 8.6-28.3 μg / mL, and the antibacterial effect on one strain of human drug-resistant pathogenic bacteria, methicillin-resistant Staphylococcus aureus, is significant, and the MIC is 16.8 μg / mL, and the 4''-O-isopentenyl fusariobutenolide C can be applied to preparation of antibacterial drug precursors, and lays a material foundation for next-step biological medicine development and application of antibacterial components.

The application discloses a heterocycle-substituted gamma, delta-unsaturated butenolide in the field of organic synthesis technology, and a structural formula is as follows: wherein the heterocycle skeleton can independently represent a benzopentazacyclic nitrogen heterocycle skeleton, a benzohexazacyclic nitrogen heterocycle skeleton, a benzopentazacyclic oxygen heterocycle skeleton, a benzohexazacyclic oxygen heterocycle skeleton or a fused heterocycle skeleton. Research finds that the compound has the activities of resisting leukemia, lung cancer, liver cancer, breast cancer and colon cancer.

The invention discloses a flavin-dependent oxidase SavA and an application of the flavin-dependent oxidase SavA in asymmetric synthesis of 4-alkyl butenolactone. The SavA enzyme provided by the invention is a novel multifunctional enzyme with desaturation, hydroxylation and lactonization effects at the same time, and can catalyze conversion of fatty acyl thioester into single-configuration (4S)-4-alkyl butene lactone. The SavA enzyme provided by the invention is a flavin-dependent enzyme and naturally exists in a form of being combined with FAD, no exogenous FAD needs to be added in an in-vitro enzymatic reaction, no other coenzyme or cofactor is involved, only O2 is used as an oxidizing agent, the reaction process is green and efficient, and the SavA enzyme has the potential of being developed into an efficient tool enzyme for asymmetric biological catalytic synthesis of 4-substituted butenolactone.

The invention discloses a cinnamic acid butenolide compound and a preparation method and application thereof.The cinnamic acid butenolide compound has the advantages of being environmentally friendly and low in toxicity, shows excellent performance in the field of insect killing and sterilization, can be widely applied to the scenes of agricultural pest control, forestry insect prevention, daily chemical antibiosis and the like, and has a wide application prospect. The compound disclosed by the invention can be used for remarkably inhibiting strawberry botrytis cinerea and colletotrichum gloeosporioides, the highest inhibition rate reaches 78%, in addition, the compound has a super-strong inhibition effect on alfalfa aphids, the inhibition rate of most compounds reaches 80% or above, the highest inhibition rate reaches 95%, and the compound has an important application value in the fields of agricultural chemistry and biological control. Besides, the preparation method is simple to operate and easy to realize through a commercialized cinnamic acid compound, does not need intermediate separation and purification, can directly and quickly synthesize a target product, and has the advantages of environmental friendliness, low toxicity, high yield, simple steps, mild conditions, wide substrate application range, simple post-treatment and the like.

The invention discloses a preparation method of a cyclic 1, 2-oxaacid ester derivative, and belongs to the technical field of organic synthesis. It is found for the first time that NaHMDS serving as alkali can promote activation of a borohydride reagent, trans-addition of propargyl alcohol is achieved, and five-membered ring 1, 2-oxaboric acid can be constructed in one step. The method has the advantages of mild reaction conditions, wide substrate range, strong functional group tolerance and specific regioselectivity. In addition, the cyclic 1, 2-oxaboric acid is also a bioisostere of a butenolactone structure, and is expected to have considerable biological activity.

The invention relates to a binder polymer obtainable by copolymerizing a monomer mixture comprising a vinyl monomer M1 and a butenolide monomer M2, wherein the vinyl monomer M1 is a vinyl ether, a vinyl ester, or a combination thereof, and the butenolide monomer M2 is a 5-alkoxy-2(5H)-furanone. The invention further relates to a coating composition comprising such binder polymer and to a substrate coated with a coating deposited from such coating composition.

The invention belongs to the technical field of biological medicines, and discloses application of a deep-sea butyrolactone compound in preparation of a medicine for preventing and / or treating inflammatory bowel diseases. The butyrolactone compound disclosed by the invention is specifically 5-acetyl-3-hydroxy-4-(4-hydroxyphenyl)-5-[4-methyl-3-(3-methylbutyl-2-ene-1-yl) benzyl] furan-2 (5H)-ketone, and the structural formula of the butyrolactone compound is shown in the description. It is proved for the first time that the butyrolactone compound has the activity of remarkably improving the inflammatory bowel disease, the body weight, defecation, intestinal length and intestinal weight of a mouse with the inflammatory bowel disease induced by DSS are remarkably improved, and the effect of the butyrolactone compound is superior to that of a positive drug salazosulfapyridine (SASP). The invention provides the application of the butyrolactone compound or the derivative thereof or the pharmaceutically acceptable salt thereof in preparing the medicine for preventing and / or treating the inflammatory bowel disease, and provides a new medicine for treating the inflammatory bowel disease, so that the butyrolactone compound has a wide application prospect.

A radiation-curable coating composition, comprising a monomer mixture comprising: a) at least one butenolide monomer A, which butenolide monomer is a substituted-5-hydroxy-2(5H)-furanone of general formula (I) wherein: n is 0 or an integer of from 1 to 5; m is 0 or 1; R1 is alkyl or aryl; X is any one of —C(O)—, —C(O)O—, —C(O)NR2—, —S(O)—, —S(O2)—, —C(O)S—, —C(S)S— and —C(S)NR2—; wherein R2 is hydrogen, alkyl or aryl; and b) at least one N-vinyl monomer B, which N-vinyl monomer is a compound of general formula (II) wherein R4 and R5 are each independently any one of hydrogen, alkyl, aryl, heteroalkyl or heteroaryl and Y is selected from O, NR6 and S; and wherein either: i) a is 1 and b is 1; or ii) a is 0 and b is 2; and wherein at least one monomer of A and B comprises at least two vinyl groups.

The invention discloses an application of biocontrol bacillus subtilis and a bactericide compound WML-01 in the prevention and treatment of soybean root rot by mixing the biocontrol bacillus subtilis and the bactericide compound WML-01 in a barrel. The biocontrol bacillus subtilis is bacillus subtilis (Bacillus subtilis) LH-01 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.36506. The bactericide WML-01 is a butylenolide compound containing a thiazolidone structure, has a wide bactericidal spectrum, and does not have cross resistance with currently common bactericide types. According to the invention, the microbial agent and the bactericide WML-01 are mixed in a barrel for use, so that the soybean root rot caused by fusarium, pythium, phytophthora sojae and rhizoctonia solani can be effectively prevented and treated, a more excellent prevention effect on the soybean root rot is shown, the use amount of chemical pesticides is reduced, more methods are provided for preventing and treating diseases by mixed use of fungus-pesticide barrels, and the method is worthy of popularization and application. Wide market application prospects are realized.

The invention provides a butenolide compound as well as a preparation method and application thereof, the compound has high biological inhibition activity as an antifouling agent and has a certain inhibition effect on gram-positive bacteria and gram-negative bacteria, and the minimum inhibitory concentrations of the compound on staphylococcus aureus and escherichia coli are 0.125 mg / mL and 0.25 mg / mL respectively. According to the preparation method, phenylalanine and pyruvic acid react to prepare phenylalanine, so that the preparation method has the characteristics of simple steps, easily available raw materials and mild conditions, and can be suitable for large-scale industrial production. According to the present invention, the structure and the anti-fouling mechanism of the compound are deeply studied, and when the compound is adopted as the active component of the anti-fouling agent and the concentration is 8.0 mg / L, the sterilization rate on escherichia coli can achieve 99.99%, and the excellent sterilization performance is provided, such that the gamma-hydroxybutenolide compound has potential application value in the field of the environment-friendly marine anti-fouling coating material as the anti-fouling agent.