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Pharmaceutical composition for treating diabetes mellitus in earlier stage

A technology of prediabetes and composition, applied in drug combination, metabolic disease, pharmaceutical formula, etc., can solve ambiguity and other problems, achieve the effect of improving clinical symptoms, delaying progress, lowering blood sugar and glycosylated hemoglobin level

Active Publication Date: 2018-06-22
BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the traditional Chinese medicine for the treatment of prediabetes, it is still unclear what the active ingredients are and what kind of ratio they are combined into a new pharmaceutical composition.

Method used

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  • Pharmaceutical composition for treating diabetes mellitus in earlier stage
  • Pharmaceutical composition for treating diabetes mellitus in earlier stage
  • Pharmaceutical composition for treating diabetes mellitus in earlier stage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A pharmaceutical composition for treating prediabetes comprises the following raw materials in parts by weight: 5 parts of epiberberine, 10 parts of coptisine, 15 parts of palmatine, 20 parts of berberine, 10 parts of astragaloside IV, and 10 parts of astragaloside I , 20 parts of acteosin glucoside, 18 parts of formononetin, 0.2 part of microcrystalline cellulose, 0.5 part of magnesium stearate, 1 part of dry starch.

[0024] The preparation method of the pharmaceutical composition for treating prediabetes is:

[0025] First mix epiberberine, coptisine, palmatine, berberine, astragaloside IV, astragaloside I, calycosin glucoside, and formononetin in proportion, and then add microcrystalline cellulose, hard Magnesium fatty acid and dried starch are mixed well and put into a tablet machine to make tablets.

[0026] Pharmacodynamic test results

[0027] Experimental animals: healthy male Wistar rats, 5 weeks old, 30 rats, 160-180 g, purchased from Beijing Weitong Lihua ...

Embodiment 2

[0033] A pharmaceutical composition for treating prediabetes comprising the following raw materials in parts by weight: 10 parts of epiberberine, 15 parts of coptisine, 20 parts of palmatine, 30 parts of berberine, 10 parts of astragaloside IV, and 5 parts of astragaloside II , astragaloside III 10 parts, astragaloside I5 parts, acteosin glucoside 25 parts, formononetin 10 parts, formononetin 10 parts, hydroxypropyl methylcellulose 0.1 parts, dextrin 0.4 parts, dry starch 0.8 share.

[0034] The preparation method of the pharmaceutical composition for treating prediabetes is:

[0035] Table berberine, coptisine, palmatine, berberine, astragaloside IV, astragaloside Ⅱ, astragaloside Ⅲ, astragaloside I, calycosin glucoside, formononetin, formononetin in proportion Mix well, then add hydroxypropyl methylcellulose, dextrin and dry starch in proportion, mix well, put into tablet machine to make tablet.

Embodiment 3

[0037] A pharmaceutical composition for treating prediabetes comprising the following raw materials in parts by weight: 15 parts of epiberberine, 20 parts of coptisine, 25 parts of palmatine, 35 parts of berberine, 15 parts of astragaloside IV, and 10 parts of astragaloside II , 15 parts of astragaloside III, 30 parts of acteosin glucoside, 20 parts of formononetin, 0.2 part of calcium hydrogen phosphate, 0.1 part of magnesium stearate, 0.2 part of starch, 0.2 part of xylitol.

[0038] The preparation method of the pharmaceutical composition for treating prediabetes is as follows: first, the above-mentioned epiberberine, coptisine, palmatine, berberine, astragaloside IV, astragaloside II, astragaloside III, calycosin glucoside, mango Mix pedicel in proportion, then add calcium hydrogen phosphate, magnesium stearate, starch, xylitol in proportion, mix well, make granules with 75% ethanol, pass through a 20 mesh sieve, dry in vacuum below 60°C, and granules, filled with No. 1 ca...

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Abstract

The invention discloses a pharmaceutical composition for treating diabetes mellitus in earlier stage. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 5-15 parts of epiberberine, 10-20 parts of coptisine, 15-25 parts of palmatine, 20-35 parts of berberine, 10-15 parts of astragaloside, 0-10 parts of astragalus saponin II, 0-15 parts of astragalus saponin III, 0-10 parts of astragalus saponin I, 20-30 parts of calycosin-7-glucoside, 0-20 parts of formononetin and 0-18 parts of ononin. The pharmaceutical composition provides a new choice for the treatment of the diabetes mellitus in the earlier stage, changes the status quo of the lack of effective prevention and treatment medicines of the diabetes mellitus in the earlier stage, can significantly improve the clinical symptoms of the diabetes mellitus in the earlier stage, significantly reduces blood glucose and glycosylated hemoglobin levels, regulates glucose metabolism, and significantly prevents or delays the progress of the diabetes mellitus in the earlier stage.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating prediabetes and a preparation method thereof. Background technique [0002] Pre-diabetes is an important stage leading to diabetes and its complications. It is reversible and concealed. Epidemiological studies show that about 500 million adults in my country are currently in pre-diabetes and it is on the rise. However, there is still no effective treatment for prediabetes. Pre-diabetes is a chronic metabolic disease, and traditional Chinese medicine has a definite clinical effect on the disease, and is listed as a dominant disease of Chinese medicine. [0003] However, in traditional Chinese medicines for the treatment of prediabetes, it is still unclear what the active ingredients are and in what proportions they are combined to form a new pharmaceutical composition. Therefore, it is of great significance to prov...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K31/7048A61K31/352A61P3/10
CPCA61K31/352A61K31/4375A61K31/7048A61K2300/00
Inventor 鄢丹张蕾冯兴中杨欣妤乐世俊王晓芳杨智睿孟欣桐刘娟
Owner BEIJING SHIJITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY
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