201results about How to "No adverse reactions were found" patented technology

The invention discloses a medicine for treating chronic hepatitis B, which contains the raw materials by the mixture ratio: 6-18% of herba artemisiae capillaries, 1-7% of Chinese thorowax, 1-7% of angelica, 3-12% of radix paeoniae alba, 3-12% of salvia miltiorrhiza, 1-10% of radix curcumae, 1-7% of rhizoma corydalis, 1-7% of common burreed rhizome, 1-7% of rhizoma zedoariae, 1-7% of nutgrass galingale rhizome, 1-7% of fructus meliae toosendan, 1-10% of dangshen, 1-7% of largehead atractylodes rhizome, 6-18% of radix astragali, 3-12% of indian bread, 1-7% of immature bitter orange, 1-7% of amomum villosum, 1-7% of areca, 0.5-5% of Chinese eaglewood and 1-7% of liquorice; the medicine is prepared by adopting conventional method. The medicine has the efficacies of clearing heat and promoting diuresis, nourishing the liver and invigorating the spleen, regulating the flow of qi and removing blood stasis, and can be used for treating chronic hepatitis B with remarkable effects, short period of treatment and rapid effects.

The invention relates to an enzyme drink and a preparation method thereof, belonging to the field of food and drinks, in particular to a ferment drink which mainly comprises the following raw materials of 8-12 parts of barley monacolin, 8-12 parts of barley malt, 0.7-1 part of lucid ganoderma mycelium, 07-1 part of cordyceps sinensis mycelium, 8-12 parts of tricholoma matsutake, 18-22 parts of sea-buckthorn, 90-110 parts of coriander root and 180-220 parts of pawpaw. The preparation method comprises the steps of: preparing the barley monacolin, fermenting the barley monacolin, gelatinizing, cooling, filtering and the like. The invention has the advantages that: plant enzymes are extracted by adopting pure natural plants, the enzyme drink contains abundant nutrients and amino acid and is rich in vitamins and functional factors, and the enzyme drink has the drinking function of the drink and the health care function of cordyceps sinensis and monacolin.

A composite essential oil for modifying the face shape relates to cosmetics and medical products, in particular to a composite essential oil for modifying the face shape. The composite essential oil comprises the following raw materials in parts by weight: 15-40 parts of cinnamon essential oil, 10-35 parts of basil essential oil, 25-65 parts of cypress essential oil, 20-45 parts of grapefruit essential oil and 1000 parts of carrier oil. The composite essential oil for modifying the face shape can be prepared by the steps of mixing and stirring the raw materials according to the proportion in the formula and then standing. The composite essential oil has the advantages of being capable of rapidly thoroughly eliminating thicker masticatory muscles on the face, removing surplus fat and improving the face contour so as to achieve the purposes of thinning the face and beautifying the skin.

The invention discloses a cataplasma which is a traditional Chinese medicine used for treating rheumatic pains and a preparation method thereof, pertaining to the technical filed of external-use preparations working as Chinese medicines treating rheumatic pains. The cataplasma is prepared by the means of extracting active ingredients of Chinese medicines and ground substances from one or more raw materials of angelica, rhizoma atractylodis sinensis, radix cynanchi paniculati and corydalis tuber; the raw materials also include one or more than one of chuanxiong rhizome, curcuma longa, frankincense, myrrh, radix achyranthis bidentatae, dactylicapnos scandens, sargentodoxa cuneata, fourstamen stephania root, geranium, tuberculate speranskia herb, nux vomica, menthol, borneol, and camphor. The prepared cataplasma utilizes the comprehensive effects generated by each component, has the efficacy of relieving rheumatism and chills, activating blood circulation to dissipate blood stasis, reducing swelling and alleviating pain and dredging the meridian passage and can effective treat diseases, such as rheumatic pains, rheumatic pains in waist, legs and back, traumatic injury, wrench, contused wound, limb pain, meridian pain, scapulohumeral periarthritis and arthroncus. The studies on zoology and clinical experiments indicate that the medicine has the advantages of strong penetrating power, quick results, short course of treatment, good curative effects, and the like, is convenient and practical and well-received by numerous patients.

The invention relates to an externally-applied plaster with the functions of detoxifying and promoting tissue regeneration. In the invention, angelica, dahurian angelica root, radix arnebiae seu lithospermi, astragalus root, radix salviae miltiorrhizae and sward are put into sesame oil and soaked, the sesame oil is heated to cause the traditional Chinese medicines in the sesame oil to be burnt into carbon, medicine residues are filtered out, mercurous chloride, red lead, mastic, myrrh and draconis sanguis are sequentially added into the sesame oil, the sesame oil is stirred and heated until the sesame oil does not fume any longer, centipede and scorpio are added into the sesame oil after the sesame oil is cooled, and then the sesame oil is evenly stirred to prepare the externally-applied plaster. The medicine is mainly used for treating diseases, such as various ulcers, purulent ulcers, bedsores, no concrescence of wounds for a long time after operation and the like, has the functions of resisting bacteria, diminishing inflammation, decreasing swelling, alleviating pain, promoting blood circulation, relieving the stasis of blood and reinforcing the bacteriostasis and sterilization capabilities of wound faces, improves the microcirculation of ulcer positions, induces the exudation of the nutritive tissue liquid of organisms, restores the effective ingredients of organism tissues and has the effects of removing putrescence, promoting tissue generation, eliminating putrescence and promoting tissue regeneration. By clinical observation, the total effective rate reaches 95%.

A Chinese medicine in the form of capsule, instant particle, or liquid for treating enterogastropathy, such as gastritis, gastric ulcer, enterogastric function disorder, enteritis, etc. is prepared from 7 Chinese-medicinal materials including yam, radish seed, amomum fruit, tangerine peel, etc. It has high curative effect.

The invention relates to a medicine for treating liver disease, which is made from the following raw materials comprising kudzuvine root, peppermint, white hyacinth bean, sharpleaf galangal fruit, tangerine peel, amomum fruit, pseudostellaria root, trogopterus dung, red sage root and membrane of chicken gizzard. The amomum fruit, white hyacinth bean, sharpleaf galangal fruit, tangerine peel and kudzuvine root are processed into fine powder; the peppermint is soaked to obtain a supernatant; the pseudostellaria root, the trogopterus dung, the red sage root and the membrane of chicken gizzard are added with water for decoction, cooled and filtered to obtain a filtrate; the drug dregs are added with water for another decoction, then cooled and filtered to obtain another filtrate; the filtrates are combined; the fine powder, the supernatant and the filtrates are mixed, and added with ethanol for lixiviation, thus preparing a semi-finished extractum product; then the extractum product is made into capsules or tablets or medicinal granule or aqua. The medicine has important effects of expelling the toxin and protecting the liver for chemical liver injuries which include alcohol liver injury and also liver injuries caused by medical, industrial and chemical harmful substances. The medicine has obvious curative effect on a plurality of liver diseases such as alcohol liver injury, fatty liver, hepatic cirrhosis, hepatitis, etc.

The invention belongs to a health-care tonic wine for drinking, and relates to a tonic wine for tonifying kidney and preserving health and a preparation method thereof, particularly a health-care tonic wine prepared from traditional Chinese medicines and a preparation method thereof. The tonic wine is mainly prepared from the following raw materials: rhizoma polygonati, ginseng, ganoderma lucidum, cynomorium, hemlock parsley, eucommia, aweto, radix rehmanniae preparata and the like. The method can accurately control the active components, is reasonable and scientific in raw material proportioning, and is easy for preparing the finished product wine; and the finished product has small color deviation, and thus, is convenient for large-scale production. The product contains multiple amino acids, minor elements and the like required by the human body, is a health-care beverage wine for nourishing and strengthening the body, and has the health-care functions of resisting fatigue and regulating immunity.

The invention discloses a compound Rhodiola rosea wine and a preparation method thereof, belongs to health-care tonic wine for people to drink, and in particular relates to a health-care tonic wine which takes Rhodiola rosea as a main raw material and a preparation method thereof. The raw materials for preparing the active ingredients of the compound Rhodiola rosea wine comprise Rhodiola rosea extractive, sea-buckthorn extractive, highland barley, tricholoma matsutake, fingered citron, Lalang Grass Rhizome and clove. The preparation method comprises the following steps: (1) decocting and extracting the highland barley, the fingered citron and the Lalang Grass Rhizome, concentrating, drying and smashing for standby; (2) smashing the tricholoma matsutake and the clove into fine powder for standby; and (3) mixing the Rhodiola rosea extractive and the sea-buckthorn extractive with mixture obtained in steps (1) and (2) and pure-grain white spirit, stirring, blending, standing, filtering and bottling to obtain the compound Rhodiola rosea wine. The compound Rhodiola rosea wine has the advantages of reasonable and scientific raw material compatibility and abundant nutrient component and has the health-care functions of fatigue resistance, immunoregulation and the like.

The invention discloses a drug for treating diabetes mellitus. The drug is prepared by the following raw materials in parts by weight: 20-100 parts of red ginseng, 100-250 parts of astragalus mongholicus, 15-30 parts of bighead atractylodes rhizome, 15-30 parts of poria cocos, 15-30 parts of fructus amomi, 15-30 parts of ginger processed pinellia, 30-60 parts of reddish orange, 30-50 parts of rhizoma zingiberis, 15-20 parts of peach kernel, 15-30 parts of carthamus tinctorius, 30-60 parts of white mustard seeds, 20-50 parts of fructus alpiniae oxyphyllae, 20-50 parts of radix linderae, 30-100 parts of rhizoma drynariae, and 15-30 parts of hard clam. The drug is strict in compatibility, dialectical, and appropriate in prescription, acts appropriately to the situation, allows the diabetes mellitus to recur difficultly after the diabetes mellitus is cured, allows complications to disappear, and allows blood sugar and urine sugar to return to normal.

The invention discloses an agarwood health-care toothpaste and a preparation method thereof. The health-care toothpaste is made of the following raw materials by weight fraction: Agarwood extract: 0.2-1.5%, toothpaste base: 98.5-99.8%. Add the agarwood extract in parts by weight into the toothpaste base, stir, fully mix, and then fill the toothpaste. The health-care toothpaste of the present invention has the effects of fragrant smell, clearing heart and refreshing mind, dredging collaterals and expelling wind, reducing inflammation and inhibiting bacteria, promoting blood circulation and relieving pain. Various symptoms of discomfort were observed, and no adverse reactions were found. Furthermore, the blood pressure of the human body can be effectively controlled, and the blood pressure of the human body can be maintained within a certain range when used for a long time. At the same time, it can play a certain role in the benign operation of human heart, liver, gastrointestinal, trachea, kidney and other functions.

The invention provides a lotion for treating gynecological disease and its preparation process, wherein the medicine is prepared from the following traditional Chinese medicinal herbs (by weight portion), cnidium fruit 30-30, kuh-seng 90-110, poria cocos wolf 40-60, peppermint 20-30.

The invention belongs to the technical field of medicines and relates to a traditional Chinese medicine composition used for treating coronary heart disease angina and a preparation method thereof. The traditional Chinese medicine composition used for treating coronary heart disease angina provided by the invention is prepared from the following traditional Chinese medicine composition raw drugs in parts by weight: 220-260 parts of vinegar-processed corydalis tuber, 4-12 parts of musk, 4-12 parts of storax, 100-140 parts of Szechuan lovage rhizome, 100-140 parts of ginseng and 6-18 parts of borneol. The traditional Chinese medicine composition provided by the invention has the efficacies of promoting the circulation of qi and resuscitating, activating blood and dissolving stasis as well as activating meridians to stop pain and is used for treating chest pain, choking sensation in chest, swelling pain at ribs, shortness of breath and palpitation which are caused by Qi-stagnation and blood stasis type coronary heart disease angina.

The invention relates to barley monascus prepared wine and a preparation method thereof, belonging to health-care nourishing wine for people to drink, in particular to health-care nourishing wine using the barley monascus as a main raw material and a preparation method thereof. The wine comprises the following raw materials in percentage by weight: 8-12 percent of barley malt, 18-22 percent of barley monascus and 4-6 percent of cordyceps militaris. The preparation method comprises the following steps of: soaking and filtering the barley malts, the barley monascus and the cordyceps militaris with pure grain white spirit to obtain filter liquor; putting the filter liquor into the pure grain white spirit and uniformly stirring; and standing still, aging, filtering and bottling. The product has the advantages of reasonable and scientific raw material matching and abundant nutrition constituents and has the effects of resisting fatigues and enhancing the immune function.

The invention discloses an aromatherapy candle and the production method thereof, the used essential oil of the aromatherapy candle is mainly composed of the raw materials with the following parts by weight: 50 parts of clove essential oil, 40 parts of patchouli essential oil, 40 parts of sweet osmanthus flower essential oil, 40 parts of turmeric root-tuber essential oil, and 20 parts of lemon essence, and the materials for preparing the candle are stearic acid and paraffin. The aromatherapy candle of the invention has the effects of giving off aromatic odor, clearing away heart-fire, refreshing, enlivening spleen, tonifying stomach, warming kidney and invigorating yang, the invention is used for refreshment, the adjuvant treatment of wind-cold abdominal pain, listlessness and fatigue, and the promotion of digestion; in addition, the invention has curative effects on stomach diseases, toothache, cough and much sputum. The invention has simple formula, simple production, significant efficacy, no toxicity, convenient usage and high application value.

The present invention discloses a fragrant curative toothpaste and a manufacturing method thereof. Essential oil applied to the fragrant curative toothpaste essentially consists of the following raw materials according to the weight portions: 30 portions of sweet osmanthus essential oil, 30 portions of turmeric root essential oil, 25 portions of notoginseng essential oil, 20 portions of pricklyash root essential oil, 10 portions of dutchmanspipe and 10 portions of mint essence. The fragrant curative toothpaste of the present invention has the efficacies of fragrant flavor, relieving heart, refreshing, dredging collaterals, dispelling wind, diminishing inflammation, inhibiting bacterium, promoting the blood circulation and acesodyne, is used for refreshing and the auxiliary treatment towards toothache, gum bleeding, gingivitis, periodontitis, oral ulcer and throat edema pain and has obvious curative effect towards tooth disease, the toothache, cough, asthma, excessive phlegm and pharyngitis. The present invention has simple prescription, simple and convenient production and obvious curative effect, is nontoxic and convenient for using and has wide application value.

The invention discloses a medicinal formula for treating barbiers or tinea pedis, which comprises 800 grams of lightyellow sophora root, 600 grams of phellodendron amurense, 800 grams of lemonfragrant angelica root, 1,200 grams of Chinese gall, 600 grams of safflower, 2,000 grams of sulfur dust, 1,800 grams of dried alum, 300 grams of rivanol, 6,000 grams of salicylic acid, 10,000 grams of benzoic acid and 20,000 milliliters of alcohol. A preparation method comprises the following steps of: A, impregnating the lightyellow sophora root, the phellodendron amurense, the lemonfragrant angelica root, the Chinese gall and the safflower in the 95 percent alcohol for 15 days and performing filtration to obtain solution A; and B, adding the dried alum, the sulfur dust, the rivanol, the salicylic acid and the benzoic acid which are weighed into the solution A for uniform mixing, and dividing the mixed solution into 100 parts for bottling or bagging. The medicinal formula can remarkably cure the diseases of barbiers, foot odor, tinea pedis and the like without remarkable adverse reaction and toxic or side effect and with the efficiency of 100 percent and the curative ratio of 98 percent, adopts the combination of Chinese medicaments and western medicaments, has little irritation to skin and high curative effect, can cure chronic and stubborn diseases from which patients suffer for a plurality of years after being taken without relapse, and has the characteristics of simple and rational preparation, readily available medicament sources and high popularization value.

The invention relates to a traditional Chinese medicine composition for treating a chronic obstructive pulmonary disease, which is prepared from the following active pharmaceutical ingredients: 10-15g of red ginseng, 10-15g of radix astragali, 10-15g of radix glycyrrhizae preparata, 10-15g of asarum, 10-15g of Brassica alba boiss, 10-15g of radix salviae miltiorrhizae, 10-15g of stemona, 10-15g of dried orange peel, 10-15g of Plantain seed, 10-15g of snakegourd fruit, 10-15g of perilla seed, 10-15g of almond, 10-15g of gecko, 10-15g of lumbricus, 10-15g of pseudo-ginseng powder, 10-15g of dried ginger and 10-15g of schisandra fruit. The active pharmaceutical ingredients adopted by the invention have mild properties, have the effects of invigorating qi, relieving asthma, promoting the dispersing function of the lung, sending down abnormally ascending, tonifying the kidney and consolidating the basis. The traditional Chinese medicine composition for treating a chronic obstructive pulmonary disease has the advantages of simple preparation process, wide medicine source, low cost and favorable curative effect. The clinical test on 40 patients proves that the effective rate is up to 90%.

The hepatosis treating medicine is prepared with kudzuvine root, mint, white hyacinth bean, galangal fruit, orange peel and amomum fruit. The preparation process includes grinding kudzuvine root, white hyacinth bean, galangal fruit, orange peel and amomum fruit into fine powder, soaking mint to obtain supernatant, mixing the fine powder and the supernatant, extracting with ethanol to obtain fluidextract and further preparation to form capsule, tablet, granule or decoction. The medicine has obvious curative effect on alcoholic liver damage, fatty liver, hepatocirrhosis and hepatitis.

The invention relates to a medicine for curing osteoporosis and the preparing method thereof. And osteoporosis is one of the frequently seen and occuring diseases in clinical practice, and the old folks frequently suffer from osteoporosis. But the existing variouis medicinal preparations have single function and curative effects less than satisfactory. The invention is composed of Epimedium Herb, Himalayan Teasel Root, Danshen, Common Anemarrhena Rhizome, Malaytea Scurfpea Fruit, and Rehmannia Root according to Chinese medicinal theory, extracts their creams and fully plays the role in tonifying kidney and strengthening bones, and promoting the blood circulation and stopping pain. And its single use on trial in the clinic shows that it has remarkable curative effect and no bad reaction occurs after long-term taken, avoiding bad reaction of combined use of plural medicines and bad interaction between medicines.

The invention discloses a compound essential oil for whitening skin and removing skin wrinkles and relates to cosmetics and a medical appliance, in particular to a compound essential oil for whitening skin and removing skin wrinkles. The compound essential oil comprises the following raw materials in percentage by weight: 30-55 percent of rosemary essential oil, 20-35 percent of tea tree essential oil, 35-55 percent of orange flower essential oil, 25-35 percent of pogostemon cablin essential oil, 25-45 percent of geranium essential oil and 1,000 percent of caper euphorbia seed essential oil. The compound essential oil for whitening skin and removing skin wrinkles of the invention is prepared by adopting the steps of mixing and stirring the raw materials according to the proportion prescription and then standing. The invention can rapidly and thoroughly whitening skin and restore skin elasticity and achieves the effects of whitening skin and removing skin wrinkles.

The invention relates to cosmetics and medical supplies, in particular to synthesis essential oil for body slimming and body building. The synthesis essential oil comprises raw materials according to weight ratio: 15-35 chamomile essential oil, 20-40 sandalwood essential oil, 25-65 needle juniper essential oil, 20-45 carrot seed essential oil and 1000 carrier oil. The raw materials are mixed, stirred and stood according to the proportional formula to prepare the synthesis essential oil for body slimming and body building. The synthesis essential oil for body slimming and body building has the advantages of quickly and completely eliminating secretion and moisture content detained subcutaneously for a long time, eliminating blocking and intumescentia of lymph and removing subcutaneous redundant fatty tissue, and has functions of body slimming and body building.

The invention relates to an ointment, and in particular discloses a moisturizing ointment for relieving infantile eczema. Infants, affected by infantile eczema, suffer great pain, and are difficult to sleep and eat comfortably, causing serious influence on infants' growth and development. In modern times, Western medicines are usually adopted for treating infantile eczema, but most Western medicines, which contain hormone substances, are high in side effect and are effective in treating symptoms, not root causes, and the infantile eczema recurs after cessation of medication; therefore, the Western medicines can take a temporary relieving effect only; although traditional Chinese medicinal preparations, which are simplex in function of clearing away heat and toxic materials, are low in side effect, the traditional Chinese medicinal preparations cannot radically cure the infantile eczema, and the phenomenon of recurrence after cessation of medication exists as well. The ointment prepared by the invention is reasonable in formula, significant in curative effect and quite low in recurrence rate, and the ointment is capable of effectively treating infant eczema, infantile eczema, miliaria, diaper dermatitis, dry skin, desquamation of skin and the like. In more than 30 years of local use, the ointment takes an excellent curative effect on treating the skin diseases in infants and is deeply loved and trusted by affected infants and parents; and the ointment, in the more than 30 years of clinical treatment, is free from adverse reaction and is quite low in recurrence rate.

The invention relates to a medicine for treating hemorrhoids, which is mainly prepared from sanguisorba, berberine hydrochloride, gallnut, artificial musk and borneol. The medicine is safe and effective and is suitable for patients suffering from different types of hemorrhoids. The invention also provides a preparation method of the medicine for treating hemorrhoids.

The invention provides a subunit vaccine immunologic adjuvant and application thereof. The adjuvant is a fusogenic peptide of antibacterial peptide and allanoin tripeptide and has an amino acid sequence of SEQ.ID.NO.1 and a nucleotide sequence of SEQIDNO.2. In the invention, PG-1-GGGGS-3BS fusogenic peptide is used as a molecular adjuvant, and the immunogenicity of the outer membrane protein of chicken pasteurella multocida can be enhanced effectively; when the PG-1-GGGGS-3BS fusogenic peptide is used as a molecular adjuvant, a eukaryotic yeast expression vector is selected, the fusogenic peptide can be expressed and purified easily, can be modified by glycosylation and the like, and is easy for mass production; the fusogenic peptide expressed by yeast has modifier genes of eukaryotic cells, is similar to the structure of PG-1 expression in a mammal body and has good biological activity.

A Chinese medicine for treating the diseases of liver and tendon, such as cramp, spasm, stiff neck, fatty liver, alcoholic liver, and hepatocirrhosis, is proportionally prepared from white peony root, Chinese angelica root, liquorice root, honeysuckle flower and parched capejasmine fruit.

The invention relates to a traditional Chinese medicine composition for treating asthma, chronic bronchitis and tracheitis through acupuncture points, which is prepared from the following raw medicines in proportioning by weight: 10-30g of white mustard seed, 20-40g of asarum, 3-10g of licorice, 3-10g of cassia, 5-15g of angelica, 5-15g of notopterygium root, 10-30g of rhizoma corydalis, 5-15g of mulberry bark, 3-10g of bighead atractylodes rhizome, 3-10g of milk vetch, 3-10g of thunbery fritillary bulb, 5-15g of balloonflower, 5-15g of tuckahoe, 5-15g of tuber pinellia, 3-10g of lily and 3-10g of herba patriniae. Various raw medicines adopted in the invention have mild properties and are safe and reliable. After acupuncture points are thermally stimulated, the traditional Chinese medicine composition has the functions of warming lung channel yang qi, dispelling internal pathogenic cold, strengthening the spleen and stomach and consolidating the constitution. The traditional Chinese medicine composition can be prepared simply and conveniently, and has the advantages of wide medicine sources, low cost and good treatment effect. Verified by 60 patients treated clinically, the effective rate is 92%.

The invention relates to the process for preparing blood-fat reduction medicaments, wherein the medicament is prepared from rice fermented with red yeast 100-250 weight parts, haw 80-150 weight parts, seaweed 80-150 weight parts, cassia seed 80-150 weight parts, gynostemma pentaphylla 80-150 weight parts and red sage root 80-150 weight parts through the steps of mixing, making immersion agent, water extracting, depression drying, disintegrating, charging starch, making tablets or capsules.

The invention discloses a traditional Chinese medicine compound for resisting breast cancer metastasis and reoccurrence. The compound includes the following components by weight: 8-10 parts of radix bupleuri, 8-15 parts of radix paeoniae alba, 8-10 parts of angelica sinensis, 8-10 parts of rhizoma pinellinae praeparata, 8-10 parts of semen citri reticulatae, 8-10 parts of selfheal, 8-10 parts of thunberg fritillary bulb, 10-30 parts of raw oyster shell, 8-10 parts of fiveleaf akebia fruit, 5-10 parts of edible tulip, 8-10 parts of curcuma zedoary, 8-30 parts of raw coix seed, 8-10 parts of pangolin scale, 8-10 parts of nidus vespae, 9-15 parts of rhizoma amorphophalli, 8-10 parts of taxus chinensis and 3-6 parts of licorice root. A preparation method and the application of the traditional Chinese medicine are further disclosed. Aiming at the basic pathogenesis of 'lier constraint, fire transmission, phlegm and blood stagnation poison and qi-blood deficiency' of breast cancer metastasis and reoccurrence, the traditional Chinese medicine compound soothes liver-qi stagnation, dissolves phlegm and stasis, clearing heat and poison, reinforcing qi, nourishing blood, is capable of remarkably reducing breast cancer metastasis and reoccurrence and has exact effects clinically.