63 results about "Human heart" patented technology

1. The name of the design product: arm type electronic sphygmomanometer. 2. The use of the design product: the design product is mainly used for detecting human heart rate pulse and blood pressure. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

This document provides a method for generating human heart organoids (hHO) with integrated macrophages (MPs), the method comprising adding monocytes to a first culture medium containing hHOs, wherein the hHOs have been differentiated for at least 5 days, and agitating the hHOs, monocytes, and the first culture medium or fresh culture medium to generate hHOs with integrated MPs. hHOs with integrated MPs prepared by the disclosed method are also provided.

The present application relates to a kind of D type personality prediction method and system based on millimeter wave radar, method includes: when target patient is diagnosed with coronary heart disease, the human heart rate variability HRV data of target patient is collected using millimeter wave radar, short-term frequency domain analysis is carried out to HRV data, and the frequency domain index parameter of target patient is obtained;Whether target patient is D type personality according to preset D type personality prediction algorithm and frequency domain index parameter is predicted;If target patient is D type personality, then target patient is carried out according to D type personality coronary heart disease prognosis.The non-contact HRV data acquisition of coronary heart disease patient is realized using millimeter wave radar, and after short-term frequency domain analysis is carried out to HRV data, the frequency domain index parameter for D type personality prediction is obtained, so as to realize the prediction of D type personality.Compared with the existing scale, the accuracy is higher, and the disease prognosis of D type personality coronary heart disease patient can be effectively improved.

A shunt device is configured to be implanted at a site of an elongated shunt opening in a tissue wall between a left atrial appendage (LAA) and a great cardiac vein (GCV) of a human heart. The shunt device includes a body portion through which a flow path extends, one or more anchoring portions connected to the body portion, and an elongated flow path opening configured to align with the elongated shunt opening in the tissue wall to permit blood to flow from the LAA into the GCV through the shunt device along the flow path.

The invention provides a composition, cell culture and application of the composition in differentiation of human pluripotent stem cells to myocardial cells and / or construction of human-derived heart organoid, and belongs to the technical field of cell engineering. The invention provides a composition. The composition comprises a fatty acid receptor antagonist, a fatty acid synthetase inhibitor and a fatty acid oxidation activator. The composition provided by the invention can regulate cell metabolism, breaks through the contradiction that the proliferation capacity and the cell maturity cannot be obtained at the same time in the traditional technology, can maintain the myocardial cells in a proliferation stage, and obtains the myocardial cells with relatively mature structures and functions, and the contractility of 3D heart organs constructed by the myocardial cells is greatly improved. The invention provides a high-quality cell source for myocardial regeneration treatment, high-throughput drug cardiotoxicity screening and heart disease mechanism research, and has remarkable clinical application value and industrialization prospect.

The invention discloses a non-invasive measurement method for measuring the stress of a heart stent, and belongs to the technical field of stress measurement. Firstly, an experimental data set is collected, a digital human body model and a power equipment digital model are generated, and a virtual scene is established; test points are set in the digital human body model, and contribution indexes of the test points are calculated and marked in combination with the experimental data set; secondly, setting an equivalent point for each marked test point in a free space in the virtual scene, and calculating a weight index and setting a weight according to the position of each equivalent point; and finally, measuring the electric field intensity and the magnetic flux density of the equivalent point, and calculating the electric field intensity and the magnetic flux density of the corresponding marked test point in combination with the weight. And calculating the electromagnetic wave energy density of the human heart stent, and measuring the stress distribution of the heart stent according to a virtual displacement method. Through in-vitro free space equivalent point measurement and a weight optimization mechanism, high-precision non-invasive measurement of the heart stent stress in a complex electromagnetic environment is realized.

The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.

A simulator apparatus for training medical professionals in various procedures involving the human clavicle and heart. The apparatus includes a clavicle model and a heart model. The clavicle model simulates a partial or full human shoulder and neck. The heart model simulates the human heart. The models may be used separately or together to practice procedures, namely inserting a central line and placing a pacemaker through a central line. The purpose of the simulator is to provide a user with a cost-effective, portable training simulator to practice performing procedures involving the shoulder, neck, and heart.

The present application belongs to the technical field of human heart rate variability signal recognition, and particularly relates to a heart rate variability signal denoising method based on Markov chain. The present application firstly uses Markov chain prediction method to analyze and calculate sample sequence, obtains the relationship between sample sequence length (N) and classification number (k) and prediction accuracy (q), then compromises the accuracy of prediction state and the accuracy of data according to the requirements of actual application, so as to determine the values of N and k, and uses the two parameters in the human heart rate variability signal (HRV) detection system, so as to improve the anti-interference performance and detection efficiency of the system. The present application belongs to the statistical method, breaks through the limitations of the existing detection system, such as weak anti-interference ability, inflexible parameter setting and low real-time performance, and can improve the work efficiency of the user; not only expands the denoising way of the heart rate variability signal detection system, but also enriches the application field of Markov chain.

A system and method for human heart modelling to create a dynamic virtual model of heart that can be used for diagnosis and determining suitable therapy. The dynamic virtual model can be created using 2D or 3D echo images or video clips obtained from ultrasound reversal wave data. Arbitrary pixels or voxels in the echo images are tracked phase-by-phase per cardiac cycle. From this, original reversal wave equation ρp attached to the arbitrary pixel or voxel is obtained. Then is generated a deformable map fp with an equation of curve passed from the arbitrary pixel or voxel within the cardiac cycle determined by solving Lagrange-Euler equations. Finally, new 2D or 3D images with improved spatial resolution can be obtained that are used for the human heart modelling.

To provide a surgical method using a catheter that enables delivery of a drug to a human heart.SOLUTION: In a surgical method of delivering chemical liquid to a cardiac muscle cell, a catheter 1 having a lumen 1L, a side opening OP communicating the lumen 1L with the outside, and a radiopaque marker M indicating a position of the side opening OP is inserted to at least one of a coronary artery and a coronary vein, the catheter 1 is rotated while checking the marker M such that an orientation of the side opening becomes a predetermined orientation, a puncture needle 21 is made to project from the side opening OP in a state where the side opening OP is in the predetermined orientation, thereby, the puncture needle 21 is stuck to a cardiac muscle as a treatment target portion, and chemical liquid 50 containing a cell for treatment is injected to the cardiac muscle from the puncture needle 21.SELECTED DRAWING: Figure 1

1. Name of the product in this design: Arm-type electronic blood pressure monitor (ZK-B877N). 2. Purpose of this design: To measure human heart rate, pulse, and blood pressure. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A method is provided herein for generating a human heart organoid (hHO) with integrated neural crest cells (NCCs), including incubating a neurosphere made from neural crest cells (NCCs) with an hHO, where the neurosphere is formed in a round-bottom or angled-bottom container. Additionally, the hHO has differentiated for about 11-17 days and / or expresses at least five times more Semaphorin-3C (SEMA3C) in comparison to an earlier hHO that has been differentiating for at least 48 hours less than the hHO. Also provided is an hHO with integrated NCCs prepared by the disclosed method. A method for evaluating the effects(s) of one or more drugs on hHO development and / or function by exposing NCCs to drugs, incorporating the NCCS into hHOs, and comparing drug-treated hHOs with integrated NCCs to non-drug-treated hHOs with NCCs is also provided.

Described is an open chest cardiac massage (OCCM) task trainer. The OCCM task trainer includes a simulated chest cavity and a simulated heart having a form factor, feel, dimensions, mechanical properties, deformability, and other characteristics that are substantially equivalent to a human heart. The OCCM task trainer includes componentry for structural support of other components and for facilitating navigation of the chest cavity by a trainee prior to simulating OCCM. The OCCM task trainer includes a simulated skin and sternum configured to be surgically separated and reformed for repeated anterior access to the chest cavity. The task trainer includes one or more sensors placed on, about, and / or within the simulated heart in order to determine the effectiveness of OCCM as simulated by a trainee. Computing circuitry and methods are described for providing real-time feedback to a trainee about the effectiveness of simulated OCCM relative to best practices for OCCM procedures.

An implantable pump includes a rigid housing with an oblate spheroid shape and having an inner chamber divided by a movable elastomeric membrane into a gas sub-chamber which is connectible through a drive line to an external pneumatic source, and a blood sub-chamber which is connectible through a graft assembly to an anatomical heart. The housing includes a blood port opening oriented at an angle and at the upper apex of the housing and connected to the blood sub-chamber, and a gas port opening to the gas sub-chamber that is situated at a lower apex of the housing. The pump is provided with a drive line that includes a gas conduit and a heart sensor, the drive line connectible to a drive system that is capable of delivering gas flow through the drive line gas conduit in response to signals driven by the heart sensor.

The invention relates to an electronic implant (100a,b) for implantation into the body of a living being and for monitoring and / or stimulating a bodily function, in particular a pacemaker for monitoring and / or stimulating the human heart, wherein the implant comprises: a housing (1a) which accommodates (i) electronics connected to an electrode (3a) configured to monitor bodily function via the electrode (3a) and / or to deliver a stimulation pulse to a body section (H), and (ii) a preferably rechargeable energy storage device (2a) for the long-term supply of electrical energy to the electronics; and an anchoring section (VA) for anchoring the electronic implant (100a,b) to the body section (H), wherein the anchoring section (VA) comprises an anchor (VA1) which is screwed into the body section (H) by a rotational movement, and a rotation lock which preferably extends in the direction of a rotational axis (RA) corresponding to the rotational movement and prevents a rotational movement of the anchor (VA1) in the opposite direction to the rotational movement after the anchor (VA1) has been screwed in.

The present application relates to the technical field of medical devices, in particular to an electronic non-affinity friction nanogenerator and a heart disease detector and a preparation method thereof. The generator comprises a first friction layer, a second friction layer, a first electrode and a second electrode; by adjusting the composition of the same material, the electron gain and loss ability of the material is changed, the first friction layer and the second friction layer are made of the same material, and the composition of the material used by the first friction layer and the second friction layer is different, so that the electron gain and loss ability of the first friction layer and the second friction layer is different, thereby realizing electronic non-affinity friction nanogeneration, using the high sensitivity to pressure to extract the characteristic signal points of the pulse wave, realizing the function of self-powered single-point detection of human heart rate, diastolic pressure and systolic pressure; in addition, it is sensitive and high, and can detect the subtle changes of the pulse wave, and since the pulse wave of a patient with heart disease is different from the normal pulse wave, it can be applied to the preparation of a heart disease detector.

1. The name of the design product: heart rate monitoring brooch (magnolia flower). 2. The use of the design product: a brooch for wearing decoration and monitoring human heart rate, matched with a monitoring magnetic buckle. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

To provide a deployment tool intended to facilitate implantation of an implant, such as a prosthetic device (e.g., a prosthetic valve), at one of the native mitral, aortic, tricuspid, or pulmonary valve regions of a human heart.SOLUTION: The delivery catheter, in various embodiments, is configured to deliver the anchoring device to an annulus of a native valve of a patient's heart, where the anchoring device can better secure the prosthesis to the native valve annulus. The sheath catheter may be utilized to deliver the delivery catheter and the catheter for deploying the prosthetic valve to the anchor device.SELECTED DRAWING: Figure 27

The application discloses a test method for blasting vibration human response and perception quantitative evaluation, and relates to the technical field of blasting protection, comprising: carrying out field test of blasting vibration human response, and collecting soil vibration and human vibration response data; carrying out vibration table test of first field human vibration response under different vibration working conditions, and obtaining vibration table parameters for simulating field blasting vibration; establishing a human vibration response model; carrying out vibration table test of second field human vibration response under different vibration working conditions, and calculating average growth rate of human heart rate variability frequency domain index value; calculating and analyzing human vibration response data; establishing quantitative relationship between average growth rate of heart rate variability frequency domain index value and human subjective feeling; establishing relationship between blasting parameters and human comfort; and establishing blasting vibration human comfort partition, wherein the application can accurately evaluate human perception under different blasting working conditions.

The Cardiac Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.

The invention provides a method, a device and a system for providing an intelligent health-related event monitoring and analyzing solution based on an artificial intelligence model of a camera and a radar sensor. Misunderstanding of human recognition is prevented by using images captured by a home / indoor camera / closed circuit television and human heart rate and breath measured based on a separately equipped radar sensor, and health-related information is provided according to measured data, or a user is automatically notified at a time when an accident risk is high or an accident occurs.

The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.

The application discloses a kind of heart dynamic simulation in-vitro experimental device, it is related to the field of computer tomography (CT), including: heart simulation device contains heart model and blood vessel model, the inner surface of the top end of left ventricle of heart model, bottom end inner surface is attached to a pair of first parallel ring;The inner surface of the top end of right ventricle, bottom end inner surface is attached to another pair of second parallel ring;Control device includes single-chip microcomputer, it has for inputting the input module of human heart real movement form electrocardiogram and for the output module of periodic control signal;Motor, it is connected with the output module of single-chip microcomputer for receiving control signal;Piston is connected with motor and does reciprocating motion, drive heart simulation device to occur contraction movement when inhale or occur diastolic movement when inflate;Many thin lines, make a pair of first parallel ring and another pair of second parallel ring rotate around vertical central axis.The application can accurately simulate human heart real movement form and then effectively carry out image calibration.

Devices and methods for replacing a malformed or defective heart are provided. The device may include a flexible hollow structure sized to deploy within the right side of the human heart. The hollow structure preferably includes an inlet, an outlet, and a one-way prosthetic valve. The hollow structure allows blood to pass therethrough and effectively replaces the function of the right side of the heart. The hollow structure is preferably flexible to allow the heart to naturally beat after deployment in the body. The device is particularly suited for the treatment of a tricuspid congenital malformation, known as Ebstein's malformation (Ebstein's malformation).

The application provides a kind of millimeter wave radar human heart rate measurement method and system based on respiratory harmonic analysis.The method uses the I / Q signal collected by millimeter wave radar, uses the extended DACM algorithm to obtain phase change information;Then analyze the time domain waveform of vital sign information, calculate the non-symmetry parameter of respiration and the pause parameter of respiratory gap, to analyze the bandwidth of dynamic adjustment notch filter, while suppressing the influence of respiratory harmonic on the heartbeat spectrum;Finally, through the time domain number peak way, the heart rate estimation range is reduced, and the Chirp-Z transform is applied to obtain higher accuracy heartbeat frequency.The heart rate measurement method of the application is simple, and compared with the previous respiratory harmonic elimination method, the strength of respiratory harmonic is more effectively analyzed and targetedly suppressed, and the measurement accuracy when the heart rate and the respiratory harmonic frequency coincide can be effectively improved.

This invention provides the application of neuregulin protein in the manufacture of drugs for preventing, treating, or delaying human heart failure, and methods for using such drugs. [Solution] The method includes: first examining the patient before treatment, wherein the examination includes detecting plasma levels of NT-proBNP or BNP; and subsequently providing appropriate treatment based on the examination results. If the examination results are within the optimal therapeutic range, the patient is suitable for treatment of heart failure by administering an effective dose of Neureglin.

This invention discloses a millimeter-wave radar method for measuring human heart rate based on adaptive notch filtering. The invention achieves stable temporal phase waveform extraction by compensating for phase jumps across distance cells caused by random human body movement and performing phase unwrapping. An adaptive notch filter is designed by extracting the respiratory fundamental frequency and bandwidth characteristics, and combined with adaptive differential processing based on local signal-to-noise ratio to obtain a filtered and differentially enhanced phase waveform. The harmonic product spectrum of the enhanced waveform is obtained, and the validity of the measurement value is judged based on confidence level. The current heart rate is then dynamically updated using the filter.

Disclosed are various embodiments of methods, components and systems configured to determine a location of a source of cardiac arrhythmia in a patient's heart. In some embodiments, to determine a source location, electrogram signals are acquired from a region of the patients' heart using a first set of electrodes; and then a pre-trained artificial intelligence (AI) model is applied to predict the location of the cardiac arrhythmia source by using the signals. Importantly, pre-training of the AI model comprises acquiring electrogram signals from explanted human hearts, the signals are generated by a second set of electrodes assembled into an electrode array that covers at least a part of the explanted human heart, and acquiring co-registered functional and / or structural imaging data in the part of the explanted human heart covered with the electrode array, wherein the functional and / or structural imaging data provide location of at least one source of cardiac arrhythmia.

An assembly for the tricuspid orifice of a human heart has an external frame connected to an internal stent carrying a tricuspid valve bioprosthesis and a sealing skirt. The external frame is configured to hold its position in the native tricuspid annulus. The internal stent is connected to the external frame by one or more fixing strands. The sealing skirt covers the interstitial space existing between the external frame and the internal stent. Developments are described which include the use of a deformable region of the frame, various alternative embodiments of the sealing skirt, the use of a frame composed of multiple sub-sections, the use of fixing strands between the stent and the frame and of fixing elements for fixing the assembly to the native tissue, the use of sensors and / or actuators, and also the use of a stent in the inferior vena cava. Method aspects are also described.