134 results about "Human heart" patented technology

Method and systems are provided for characterizing blood flow in an atrioventricular valve of the human heart, the atrioventricular valve connecting an atrium with a corresponding ventricle of the heart, the ventricle being fluidly coupled to a particular vessel that transports blood outside the ventricle blood, which involve obtaining image data of the heart and identifying contours of the atrium and a region within the particular vessel within the image data. A time-density curve for the atrium can be calculated from the contour of the atrium and densitometric image data derived from the image data. A time-density curve for the region of the particular vessel can be calculated from the contour of the vessel region and the densitometric image data. Data that characterizes at least one regurgitation fraction related to the atrioventricular valve can be calculated from such time-density curves.

The invention discloses a non-contact electrocardio detection method which comprises the following steps: transmitting a frequency modulation continuous wave signal to the heart part of a human body by using an MIMO millimeter wave radar so as to obtain an echo signal reflected by the human body and pre-process the echo signal to obtain a discrete three-dimensional radar signal; enhancing the discrete three-dimensional radar signal by using a 2D beam forming technology to obtain a 2D signal; extracting a target area signal from the 2D signal, and performing phase extraction on the extracted target area signal to obtain phase data; the method comprises the following steps: constructing a WaveGRU-Net network comprising an MODWT module, a CNN module and a Bi-GRU module; and training the WaveGRU-Net network by using the phase data so as to output a reconstructed electrocardiogram by using the trained WaveGRU-Net network, thereby realizing non-contact electrocardiogram detection. According to the method, accurate extraction of the electrocardiosignal is realized, and meanwhile, the signal reconstruction precision is improved.

The invention belongs to the technical field of biological medicine, and particularly discloses an artificial valve tissue calcification model and a preparation method and application thereof. The preparation method comprises the following steps: providing human valvular interstitial cells; the method comprises the following steps: providing a hydrogel system, wherein the hydrogel system comprises type I collagen, fibrinogen and Matrigel matrigel; constructing an engineered heart valve tissue strip by taking the hydrogel system as a skeleton structure between valve interstitial cells; and culturing the engineered heart valve tissue strip by using a calcification induction culture solution, so that the valve tissue generates a calcification phenotype. The model provided by the invention can generate a valve calcification phenotype which is similar to that after human heart valve calcification and is represented by valve interstitial cell activation, extracellular matrix remodeling such as collagen mass secretion and calcium deposition region generation. The model provided by the invention is low in cost, can be produced in batches, meets the research on the pathogenesis of extracorporeal valve calcification, and makes up for the dilemma that no artificial valve calcification model is available for drug research and development at present.

Implant for improving coaptation of an atrioventricular valve in a human heart, the atrioventricular valve having a first and a second native leaflet, an anterolateral and posteromedial commissure between the first and the second native leaflet, and an annulus adjacent a wall of an atrium of the heart. The implant including a frame that includes a middle frame section that frames and supports an artificial central leaflet. The artificial central leaflet is configured to cover a middle region of the first native leaflet. The middle frame section includes a bend formed between a first region of the artificial central leaflet and a second region of the artificial central leaflet that forms a coaptation plane for coaptation with the second native leaflet. The frame further including two side frame sections extending at opposite sides of the middle frame section and configured to contact side regions of the first native leaflet.

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

The present invention provides an artificial heart pump device and a preparation method of a magnetic diaphragm pump, belonging to the field of medical devices. The artificial heart pump device includes a magnetic diaphragm pump system and a magnetic field generating system; the magnetic diaphragm pump includes a magnetic diaphragm and a non-magnetic pump body; after the magnetic diaphragm is magnetized radially, it deforms under a uniform magnetic field; the non-magnetic pump body cooperates with the magnetic diaphragm to generate elastic deformation, and realizes the function of pumping blood by changing the volume of the magnetic diaphragm pump; a hose connects each artery or vein where the magnetic diaphragm pump is connected to the human heart to complete the transportation and circulation of blood in the human blood vessels and the magnetic diaphragm pump; a one-way valve controls the one-way flow of blood; the magnetic field generating system generates a uniform magnetic field along the axial direction of the magnetic diaphragm. The artificial heart pump device provided by the present invention has higher operation reliability and longer service life.

1. The name of the design product: arm type electronic sphygmomanometer. 2. The use of the design product: the design product is mainly used for detecting human heart rate pulse and blood pressure. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

This document provides a method for generating human heart organoids (hHO) with integrated macrophages (MPs), the method comprising adding monocytes to a first culture medium containing hHOs, wherein the hHOs have been differentiated for at least 5 days, and agitating the hHOs, monocytes, and the first culture medium or fresh culture medium to generate hHOs with integrated MPs. hHOs with integrated MPs prepared by the disclosed method are also provided.

The invention relates to a simulator comprising a flexible simulation chamber simulating a living body chamber, the flexible simulation chamber having at least one opening; a valve comprising a valve leaflet; a papillary muscle entity model; and chordae tendineae connecting the papillary muscle entity model and the valve leaflets; at least one valve arm extends through the flexible simulation cavity, so that the far end of the valve arm is arranged in the flexible simulation cavity, the near end of the valve arm is arranged outside the flexible simulation cavity, the far end of the valve arm is fixed relative to the papillary muscle entity model, and the position of the far end of the valve arm can be controlled from the near end; and a control device for controlling the simulation process. Such a simulator allows for precise simulation of motion of a living body chamber, such as the left ventricle or the right ventricle of a human heart, in which case precise rotation and / or other motion of the chamber during a pulsation can be simulated.

The present application relates to a kind of D type personality prediction method and system based on millimeter wave radar, method includes: when target patient is diagnosed with coronary heart disease, the human heart rate variability HRV data of target patient is collected using millimeter wave radar, short-term frequency domain analysis is carried out to HRV data, and the frequency domain index parameter of target patient is obtained;Whether target patient is D type personality according to preset D type personality prediction algorithm and frequency domain index parameter is predicted;If target patient is D type personality, then target patient is carried out according to D type personality coronary heart disease prognosis.The non-contact HRV data acquisition of coronary heart disease patient is realized using millimeter wave radar, and after short-term frequency domain analysis is carried out to HRV data, the frequency domain index parameter for D type personality prediction is obtained, so as to realize the prediction of D type personality.Compared with the existing scale, the accuracy is higher, and the disease prognosis of D type personality coronary heart disease patient can be effectively improved.

A shunt device is configured to be implanted at a site of an elongated shunt opening in a tissue wall between a left atrial appendage (LAA) and a great cardiac vein (GCV) of a human heart. The shunt device includes a body portion through which a flow path extends, one or more anchoring portions connected to the body portion, and an elongated flow path opening configured to align with the elongated shunt opening in the tissue wall to permit blood to flow from the LAA into the GCV through the shunt device along the flow path.

The invention provides a composition, cell culture and application of the composition in differentiation of human pluripotent stem cells to myocardial cells and / or construction of human-derived heart organoid, and belongs to the technical field of cell engineering. The invention provides a composition. The composition comprises a fatty acid receptor antagonist, a fatty acid synthetase inhibitor and a fatty acid oxidation activator. The composition provided by the invention can regulate cell metabolism, breaks through the contradiction that the proliferation capacity and the cell maturity cannot be obtained at the same time in the traditional technology, can maintain the myocardial cells in a proliferation stage, and obtains the myocardial cells with relatively mature structures and functions, and the contractility of 3D heart organs constructed by the myocardial cells is greatly improved. The invention provides a high-quality cell source for myocardial regeneration treatment, high-throughput drug cardiotoxicity screening and heart disease mechanism research, and has remarkable clinical application value and industrialization prospect.

A selective blocking door device includes a coupling assembly that is configured to be removably secured to a mating base that is secured to a human heart. A frame assembly is secured to the coupling assembly, and a closure assembly is configured to linearly displace within opposing lateral slots of the frame assembly from a first open position to a second closed position. In the open position, no portion of the closure assembly is configured to be aligned with a central aperture of the mating base such that the central aperture is clear of any obstruction by the closure assembly. In the closed position, a portion of the closure assembly is configured to be aligned with the central aperture of the mating base such that the central aperture is covered and obstructed by a portion of the closure assembly.

1. The name of the product of this design: Arm Cuff Sphygmomanometer (ZK‑B888). 2. Purpose of the product of this design: used to detect human heart rate, pulse and blood pressure. 3. The design key point of this appearance design product lies in the shape. 4. The picture or photo that best illustrates the design points: Stereoscopic diagram 1.

The invention discloses a non-invasive measurement method for measuring the stress of a heart stent, and belongs to the technical field of stress measurement. Firstly, an experimental data set is collected, a digital human body model and a power equipment digital model are generated, and a virtual scene is established; test points are set in the digital human body model, and contribution indexes of the test points are calculated and marked in combination with the experimental data set; secondly, setting an equivalent point for each marked test point in a free space in the virtual scene, and calculating a weight index and setting a weight according to the position of each equivalent point; and finally, measuring the electric field intensity and the magnetic flux density of the equivalent point, and calculating the electric field intensity and the magnetic flux density of the corresponding marked test point in combination with the weight. And calculating the electromagnetic wave energy density of the human heart stent, and measuring the stress distribution of the heart stent according to a virtual displacement method. Through in-vitro free space equivalent point measurement and a weight optimization mechanism, high-precision non-invasive measurement of the heart stent stress in a complex electromagnetic environment is realized.

The invention discloses a portable human heart imaging hardware system based on bioelectrical impedance. The system comprises an excitation signal processing module, a detection signal conditioning module and a digital processing module. The excitation signal processing module adopts a DAC (Digital-to-Analog Converter) to generate an excitation signal, and after voltage amplification and band-pass filtering, the excitation signal drives an excitation electrode through an analog switch; the detection signal conditioning module switches a measuring electrode through an analog switch, a programmable instrumentation amplifier is combined with an RDAC digital potentiometer to realize self-adaptive gain adjustment of a detection signal, flexible gain of the signal is realized, and the signal is sent to an ADC after being filtered; the digital processing module carries out digital demodulation on the collected signals, extracts amplitude and phase information and then transmits the amplitude and phase information to an upper computer for image reconstruction. The flexible signal gain mechanism of the system realizes a full-custom signal gain curve, breaks through the fixed magnification gain limitation of the traditional integrated PGA, adapts to the impedance change of different individuals and experimental media, and improves the signal-to-noise ratio of the system, thereby obtaining more accurate cardiac impedance acquisition data.

1. The name of this design product: digital stethoscope. 2. Purpose of this product design: This product design is used for auscultating human heart and lung sounds. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.

A total artificial heart system includes at least one artificial ventricle coupled to (or capable of being coupled to) a chamber or a vessel of a human heart, and at least one drive system coupled to the artificial ventricle, the drive system including at least one implanted electric motor. The drive system causes the artificial ventricle to contract and expand.

The invention belongs to the technical field of medicines, and particularly relates to a milk acylation modified Myh6 protein and application thereof. The antigen polypeptide for identifying the heart failure marker has an amino acid sequence as shown in SEQ ID NO: 1, lysine located at the 9th site is subjected to milk acylation modification, and the heart failure marker is milk acylation modified Myh6 protein; the milk acylation modified Myh6 protein is a lysine milk acylation modified protein (Myh6-K1897) which is located at the 1897 site of a wild type Myh6 protein. The Myh6-K1897 can be used as a marker for identifying heart failure as a target spot, is a set of novel and perfect protein milk acylation molecular regulation and control system, can judge the interaction between Myh6 and Tin, and is used for treating the core and key of heart failure. The research provides a new and powerful treatment strategy for the treatment of human heart failure diseases.

The present invention provides a signal device for simulating human heart shock and respiratory vibration, including a vibration signal generator and a vibration simulator that cooperate with each other. The vibration signal generator includes a first electromagnet, a second electromagnet, and an analog signal amplifier. Both the first electromagnet and the second electromagnet are electrically connected to the analog signal amplifier. The vibration simulator includes a counterweight with a certain weight, and a first permanent magnet and a second permanent magnet fixed on the top of the counterweight. A method for simulating signals of vibration caused by human heart shock and respiration is also disclosed, which can simultaneously simulate two or more vibration signals and form a superimposed effect, closer to the real heart shock and respiratory vibration effects, and can test the qualification of a ballistocardiogram device by simulating known vibration signals, reducing errors.

A simulator apparatus for training medical professionals in various procedures involving the human clavicle and heart. The apparatus includes a clavicle model and a heart model. The clavicle model simulates a partial or full human shoulder and neck. The heart model simulates the human heart. The models may be used separately or together to practice procedures, namely inserting a central line and placing a pacemaker through a central line. The purpose of the simulator is to provide a user with a cost-effective, portable training simulator to practice performing procedures involving the shoulder, neck, and heart.

The present application belongs to the technical field of human heart rate variability signal recognition, and particularly relates to a heart rate variability signal denoising method based on Markov chain. The present application firstly uses Markov chain prediction method to analyze and calculate sample sequence, obtains the relationship between sample sequence length (N) and classification number (k) and prediction accuracy (q), then compromises the accuracy of prediction state and the accuracy of data according to the requirements of actual application, so as to determine the values of N and k, and uses the two parameters in the human heart rate variability signal (HRV) detection system, so as to improve the anti-interference performance and detection efficiency of the system. The present application belongs to the statistical method, breaks through the limitations of the existing detection system, such as weak anti-interference ability, inflexible parameter setting and low real-time performance, and can improve the work efficiency of the user; not only expands the denoising way of the heart rate variability signal detection system, but also enriches the application field of Markov chain.

A system and method for human heart modelling to create a dynamic virtual model of heart that can be used for diagnosis and determining suitable therapy. The dynamic virtual model can be created using 2D or 3D echo images or video clips obtained from ultrasound reversal wave data. Arbitrary pixels or voxels in the echo images are tracked phase-by-phase per cardiac cycle. From this, original reversal wave equation ρp attached to the arbitrary pixel or voxel is obtained. Then is generated a deformable map fp with an equation of curve passed from the arbitrary pixel or voxel within the cardiac cycle determined by solving Lagrange-Euler equations. Finally, new 2D or 3D images with improved spatial resolution can be obtained that are used for the human heart modelling.

To provide a surgical method using a catheter that enables delivery of a drug to a human heart.SOLUTION: In a surgical method of delivering chemical liquid to a cardiac muscle cell, a catheter 1 having a lumen 1L, a side opening OP communicating the lumen 1L with the outside, and a radiopaque marker M indicating a position of the side opening OP is inserted to at least one of a coronary artery and a coronary vein, the catheter 1 is rotated while checking the marker M such that an orientation of the side opening becomes a predetermined orientation, a puncture needle 21 is made to project from the side opening OP in a state where the side opening OP is in the predetermined orientation, thereby, the puncture needle 21 is stuck to a cardiac muscle as a treatment target portion, and chemical liquid 50 containing a cell for treatment is injected to the cardiac muscle from the puncture needle 21.SELECTED DRAWING: Figure 1

The invention discloses a miR-92a-1-5p high expression vector for improving cardiac fibrosis and a fibroblast cell line. The invention provides a DNA fragment for expressing miR-92a-5p, the sequence of the DNA fragment is shown as SEQ ID NO: 4, the invention also provides an expression vector containing a target gene sequence shown as SEQ ID NO: 4 and a human heart fibroblast cell line with high expression of miR-92a-1-5p, and the cell line can improve the fiber activation capability of human heart fibroblasts, inhibit the migration capability of the fibroblasts, and improve the human heart fibroblasts. And the collagen shrinkage capability of fibroblasts is inhibited. In addition, the miR-92a-1-5p overexpression recombinant vector constructed by the invention is helpful for exploring the molecular mechanism of the miR-92a-1-5p in the occurrence and development of fibrosis diseases such as fibrosis after myocardial infarction, and is helpful for developing a therapeutic scheme of the fibrosis diseases; the method has an important application value.

1. Name of the product in this design: Arm-type electronic blood pressure monitor (ZK-B877N). 2. Purpose of this design: To measure human heart rate, pulse, and blood pressure. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A method is provided herein for generating a human heart organoid (hHO) with integrated neural crest cells (NCCs), including incubating a neurosphere made from neural crest cells (NCCs) with an hHO, where the neurosphere is formed in a round-bottom or angled-bottom container. Additionally, the hHO has differentiated for about 11-17 days and / or expresses at least five times more Semaphorin-3C (SEMA3C) in comparison to an earlier hHO that has been differentiating for at least 48 hours less than the hHO. Also provided is an hHO with integrated NCCs prepared by the disclosed method. A method for evaluating the effects(s) of one or more drugs on hHO development and / or function by exposing NCCs to drugs, incorporating the NCCS into hHOs, and comparing drug-treated hHOs with integrated NCCs to non-drug-treated hHOs with NCCs is also provided.

Described is an open chest cardiac massage (OCCM) task trainer. The OCCM task trainer includes a simulated chest cavity and a simulated heart having a form factor, feel, dimensions, mechanical properties, deformability, and other characteristics that are substantially equivalent to a human heart. The OCCM task trainer includes componentry for structural support of other components and for facilitating navigation of the chest cavity by a trainee prior to simulating OCCM. The OCCM task trainer includes a simulated skin and sternum configured to be surgically separated and reformed for repeated anterior access to the chest cavity. The task trainer includes one or more sensors placed on, about, and / or within the simulated heart in order to determine the effectiveness of OCCM as simulated by a trainee. Computing circuitry and methods are described for providing real-time feedback to a trainee about the effectiveness of simulated OCCM relative to best practices for OCCM procedures.

A non-contact cardiogram measurement method is disclosed. The method includes: measuring, by a Doppler radar or a pulse radar, a distance change between the radar and a skin surface through an electromagnetic wave, a light wave and a sound wave; deriving a displacement curve indicating a change in a human heart volume; taking first-order and second-order derivations of the displacement curve to acquire velocity and acceleration curves; taking zero points and extreme points of the velocity and acceleration curves as velocity and acceleration information, and as characteristic points of different stages of atrial and ventricular systole and diastole; acquiring time, volume change, velocity and acceleration information of atrial and ventricular systole and diastole in a cardiac cycle. The present disclosure features low cost and low radiation hazard, avoids direct contact with the human body, and provides a convenient and easy way for daily cardiac diagnostic measurement of special patients.