105 results about "Human heart" patented technology

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

1. The name of the design product: arm type electronic sphygmomanometer. 2. The use of the design product: the design product is mainly used for detecting human heart rate pulse and blood pressure. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

This document provides a method for generating human heart organoids (hHO) with integrated macrophages (MPs), the method comprising adding monocytes to a first culture medium containing hHOs, wherein the hHOs have been differentiated for at least 5 days, and agitating the hHOs, monocytes, and the first culture medium or fresh culture medium to generate hHOs with integrated MPs. hHOs with integrated MPs prepared by the disclosed method are also provided.

The present application relates to a kind of D type personality prediction method and system based on millimeter wave radar, method includes: when target patient is diagnosed with coronary heart disease, the human heart rate variability HRV data of target patient is collected using millimeter wave radar, short-term frequency domain analysis is carried out to HRV data, and the frequency domain index parameter of target patient is obtained;Whether target patient is D type personality according to preset D type personality prediction algorithm and frequency domain index parameter is predicted;If target patient is D type personality, then target patient is carried out according to D type personality coronary heart disease prognosis.The non-contact HRV data acquisition of coronary heart disease patient is realized using millimeter wave radar, and after short-term frequency domain analysis is carried out to HRV data, the frequency domain index parameter for D type personality prediction is obtained, so as to realize the prediction of D type personality.Compared with the existing scale, the accuracy is higher, and the disease prognosis of D type personality coronary heart disease patient can be effectively improved.

A shunt device is configured to be implanted at a site of an elongated shunt opening in a tissue wall between a left atrial appendage (LAA) and a great cardiac vein (GCV) of a human heart. The shunt device includes a body portion through which a flow path extends, one or more anchoring portions connected to the body portion, and an elongated flow path opening configured to align with the elongated shunt opening in the tissue wall to permit blood to flow from the LAA into the GCV through the shunt device along the flow path.

The invention provides a composition, cell culture and application of the composition in differentiation of human pluripotent stem cells to myocardial cells and / or construction of human-derived heart organoid, and belongs to the technical field of cell engineering. The invention provides a composition. The composition comprises a fatty acid receptor antagonist, a fatty acid synthetase inhibitor and a fatty acid oxidation activator. The composition provided by the invention can regulate cell metabolism, breaks through the contradiction that the proliferation capacity and the cell maturity cannot be obtained at the same time in the traditional technology, can maintain the myocardial cells in a proliferation stage, and obtains the myocardial cells with relatively mature structures and functions, and the contractility of 3D heart organs constructed by the myocardial cells is greatly improved. The invention provides a high-quality cell source for myocardial regeneration treatment, high-throughput drug cardiotoxicity screening and heart disease mechanism research, and has remarkable clinical application value and industrialization prospect.

A selective blocking door device includes a coupling assembly that is configured to be removably secured to a mating base that is secured to a human heart. A frame assembly is secured to the coupling assembly, and a closure assembly is configured to linearly displace within opposing lateral slots of the frame assembly from a first open position to a second closed position. In the open position, no portion of the closure assembly is configured to be aligned with a central aperture of the mating base such that the central aperture is clear of any obstruction by the closure assembly. In the closed position, a portion of the closure assembly is configured to be aligned with the central aperture of the mating base such that the central aperture is covered and obstructed by a portion of the closure assembly.

The invention discloses a non-invasive measurement method for measuring the stress of a heart stent, and belongs to the technical field of stress measurement. Firstly, an experimental data set is collected, a digital human body model and a power equipment digital model are generated, and a virtual scene is established; test points are set in the digital human body model, and contribution indexes of the test points are calculated and marked in combination with the experimental data set; secondly, setting an equivalent point for each marked test point in a free space in the virtual scene, and calculating a weight index and setting a weight according to the position of each equivalent point; and finally, measuring the electric field intensity and the magnetic flux density of the equivalent point, and calculating the electric field intensity and the magnetic flux density of the corresponding marked test point in combination with the weight. And calculating the electromagnetic wave energy density of the human heart stent, and measuring the stress distribution of the heart stent according to a virtual displacement method. Through in-vitro free space equivalent point measurement and a weight optimization mechanism, high-precision non-invasive measurement of the heart stent stress in a complex electromagnetic environment is realized.

The invention discloses a portable human heart imaging hardware system based on bioelectrical impedance. The system comprises an excitation signal processing module, a detection signal conditioning module and a digital processing module. The excitation signal processing module adopts a DAC (Digital-to-Analog Converter) to generate an excitation signal, and after voltage amplification and band-pass filtering, the excitation signal drives an excitation electrode through an analog switch; the detection signal conditioning module switches a measuring electrode through an analog switch, a programmable instrumentation amplifier is combined with an RDAC digital potentiometer to realize self-adaptive gain adjustment of a detection signal, flexible gain of the signal is realized, and the signal is sent to an ADC after being filtered; the digital processing module carries out digital demodulation on the collected signals, extracts amplitude and phase information and then transmits the amplitude and phase information to an upper computer for image reconstruction. The flexible signal gain mechanism of the system realizes a full-custom signal gain curve, breaks through the fixed magnification gain limitation of the traditional integrated PGA, adapts to the impedance change of different individuals and experimental media, and improves the signal-to-noise ratio of the system, thereby obtaining more accurate cardiac impedance acquisition data.

1. The name of this design product: digital stethoscope. 2. Purpose of this product design: This product design is used for auscultating human heart and lung sounds. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The Cardio-Tox Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.

A total artificial heart system includes at least one artificial ventricle coupled to (or capable of being coupled to) a chamber or a vessel of a human heart, and at least one drive system coupled to the artificial ventricle, the drive system including at least one implanted electric motor. The drive system causes the artificial ventricle to contract and expand.

The invention belongs to the technical field of medicines, and particularly relates to a milk acylation modified Myh6 protein and application thereof. The antigen polypeptide for identifying the heart failure marker has an amino acid sequence as shown in SEQ ID NO: 1, lysine located at the 9th site is subjected to milk acylation modification, and the heart failure marker is milk acylation modified Myh6 protein; the milk acylation modified Myh6 protein is a lysine milk acylation modified protein (Myh6-K1897) which is located at the 1897 site of a wild type Myh6 protein. The Myh6-K1897 can be used as a marker for identifying heart failure as a target spot, is a set of novel and perfect protein milk acylation molecular regulation and control system, can judge the interaction between Myh6 and Tin, and is used for treating the core and key of heart failure. The research provides a new and powerful treatment strategy for the treatment of human heart failure diseases.

A simulator apparatus for training medical professionals in various procedures involving the human clavicle and heart. The apparatus includes a clavicle model and a heart model. The clavicle model simulates a partial or full human shoulder and neck. The heart model simulates the human heart. The models may be used separately or together to practice procedures, namely inserting a central line and placing a pacemaker through a central line. The purpose of the simulator is to provide a user with a cost-effective, portable training simulator to practice performing procedures involving the shoulder, neck, and heart.

The present application belongs to the technical field of human heart rate variability signal recognition, and particularly relates to a heart rate variability signal denoising method based on Markov chain. The present application firstly uses Markov chain prediction method to analyze and calculate sample sequence, obtains the relationship between sample sequence length (N) and classification number (k) and prediction accuracy (q), then compromises the accuracy of prediction state and the accuracy of data according to the requirements of actual application, so as to determine the values of N and k, and uses the two parameters in the human heart rate variability signal (HRV) detection system, so as to improve the anti-interference performance and detection efficiency of the system. The present application belongs to the statistical method, breaks through the limitations of the existing detection system, such as weak anti-interference ability, inflexible parameter setting and low real-time performance, and can improve the work efficiency of the user; not only expands the denoising way of the heart rate variability signal detection system, but also enriches the application field of Markov chain.

A system and method for human heart modelling to create a dynamic virtual model of heart that can be used for diagnosis and determining suitable therapy. The dynamic virtual model can be created using 2D or 3D echo images or video clips obtained from ultrasound reversal wave data. Arbitrary pixels or voxels in the echo images are tracked phase-by-phase per cardiac cycle. From this, original reversal wave equation ρp attached to the arbitrary pixel or voxel is obtained. Then is generated a deformable map fp with an equation of curve passed from the arbitrary pixel or voxel within the cardiac cycle determined by solving Lagrange-Euler equations. Finally, new 2D or 3D images with improved spatial resolution can be obtained that are used for the human heart modelling.

To provide a surgical method using a catheter that enables delivery of a drug to a human heart.SOLUTION: In a surgical method of delivering chemical liquid to a cardiac muscle cell, a catheter 1 having a lumen 1L, a side opening OP communicating the lumen 1L with the outside, and a radiopaque marker M indicating a position of the side opening OP is inserted to at least one of a coronary artery and a coronary vein, the catheter 1 is rotated while checking the marker M such that an orientation of the side opening becomes a predetermined orientation, a puncture needle 21 is made to project from the side opening OP in a state where the side opening OP is in the predetermined orientation, thereby, the puncture needle 21 is stuck to a cardiac muscle as a treatment target portion, and chemical liquid 50 containing a cell for treatment is injected to the cardiac muscle from the puncture needle 21.SELECTED DRAWING: Figure 1

1. Name of the product in this design: Arm-type electronic blood pressure monitor (ZK-B877N). 2. Purpose of this design: To measure human heart rate, pulse, and blood pressure. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A method is provided herein for generating a human heart organoid (hHO) with integrated neural crest cells (NCCs), including incubating a neurosphere made from neural crest cells (NCCs) with an hHO, where the neurosphere is formed in a round-bottom or angled-bottom container. Additionally, the hHO has differentiated for about 11-17 days and / or expresses at least five times more Semaphorin-3C (SEMA3C) in comparison to an earlier hHO that has been differentiating for at least 48 hours less than the hHO. Also provided is an hHO with integrated NCCs prepared by the disclosed method. A method for evaluating the effects(s) of one or more drugs on hHO development and / or function by exposing NCCs to drugs, incorporating the NCCS into hHOs, and comparing drug-treated hHOs with integrated NCCs to non-drug-treated hHOs with NCCs is also provided.

Described is an open chest cardiac massage (OCCM) task trainer. The OCCM task trainer includes a simulated chest cavity and a simulated heart having a form factor, feel, dimensions, mechanical properties, deformability, and other characteristics that are substantially equivalent to a human heart. The OCCM task trainer includes componentry for structural support of other components and for facilitating navigation of the chest cavity by a trainee prior to simulating OCCM. The OCCM task trainer includes a simulated skin and sternum configured to be surgically separated and reformed for repeated anterior access to the chest cavity. The task trainer includes one or more sensors placed on, about, and / or within the simulated heart in order to determine the effectiveness of OCCM as simulated by a trainee. Computing circuitry and methods are described for providing real-time feedback to a trainee about the effectiveness of simulated OCCM relative to best practices for OCCM procedures.

An implantable pump includes a rigid housing with an oblate spheroid shape and having an inner chamber divided by a movable elastomeric membrane into a gas sub-chamber which is connectible through a drive line to an external pneumatic source, and a blood sub-chamber which is connectible through a graft assembly to an anatomical heart. The housing includes a blood port opening oriented at an angle and at the upper apex of the housing and connected to the blood sub-chamber, and a gas port opening to the gas sub-chamber that is situated at a lower apex of the housing. The pump is provided with a drive line that includes a gas conduit and a heart sensor, the drive line connectible to a drive system that is capable of delivering gas flow through the drive line gas conduit in response to signals driven by the heart sensor.

Systems, apparatuses, and methods disclosed herein are provided for medical treatment, including transcatheter medical treatments and / or for treatment of dilated hearts (e.g., dilated left ventricle) or functional mitral valve regurgitation within a human heart. The systems, apparatuses, and methods disclosed herein may include applying one or more heart splints to the patient's heart to apply pressure to the heart to reshape the heart. Anchors disclosed herein may be utilized in plugs for treating openings in a septum between two chambers of a heart, e.g., ventricular septal defects (VSD), atrial septal defects (ASD), and patent foramen ovale (PFO). In addition, the anchors disclosed herein may be utilized to reshape an annulus of a patient's heart valve, including a tricuspid valve of a patient's heart. The anchors disclosed herein may also be utilized to reposition a heart valve leaflet to reduce heart valve leaflet prolapse.

The invention relates to an electronic implant (100a,b) for implantation into the body of a living being and for monitoring and / or stimulating a bodily function, in particular a pacemaker for monitoring and / or stimulating the human heart, wherein the implant comprises: a housing (1a) which accommodates (i) electronics connected to an electrode (3a) configured to monitor bodily function via the electrode (3a) and / or to deliver a stimulation pulse to a body section (H), and (ii) a preferably rechargeable energy storage device (2a) for the long-term supply of electrical energy to the electronics; and an anchoring section (VA) for anchoring the electronic implant (100a,b) to the body section (H), wherein the anchoring section (VA) comprises an anchor (VA1) which is screwed into the body section (H) by a rotational movement, and a rotation lock which preferably extends in the direction of a rotational axis (RA) corresponding to the rotational movement and prevents a rotational movement of the anchor (VA1) in the opposite direction to the rotational movement after the anchor (VA1) has been screwed in.

The present application relates to the technical field of medical equipment, in particular to an external counterpulsation instrument. It comprises: an electrocardiogram detection module, an electroencephalogram detection module, a magnetic stimulation intelligent device module and a central processing unit module. The electrocardiogram detection module is used for measuring the electrocardiogram pulse signal of the human body to be measured; the electroencephalogram detection module is used for detecting the brain wave signal of the brain of the human body to be measured; the central processing unit module is used for receiving the electrocardiogram pulse signal and the brain wave signal, and comprehensively analyzing and processing the electrocardiogram pulse signal and the brain wave signal to obtain the frequency and timing information of the human heart contraction, and obtaining the corresponding magnetic stimulation trigger signal according to the frequency and timing information of the heart contraction; the magnetic stimulation intelligent device module is used for receiving the magnetic stimulation trigger signal and generating the corresponding magnetic stimulation signal under the triggering of the magnetic stimulation trigger signal, so as to perform magnetic stimulation processing on the human body to be measured. The present application stimulates the human muscle nerves and brain nerves by using the magnetic field, and achieves the same treatment effect as the conventional air pressure type external counterpulsation instrument.

The application discloses an ion conductive hydrogel and a preparation method and application thereof, relates to the technical field of functional hydrogel and sensors, and discloses the ion conductive hydrogel which comprises a gel-forming monomer, a crosslinking agent, an inorganic salt and a photoinitiator; the gel-forming monomer comprises acrylamide and zwitterionic monomer sulfobetaine methacrylate; the crosslinking agent is N, N'-methylene bisacrylamide; the photoinitiator is 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone; and the solvent is deionized water. Based on the ion conductive hydrogel, an ion conductive hydrogel electrode patch can be prepared; by means of a wearable device, the ion conductive hydrogel electrode patch can be adhered to a human heart part, safe and comfortable heart rate variability data acquisition of the human body can be realized, and then the detection of CAN can be realized.

The present application relates to the technical field of medical devices, in particular to an electronic non-affinity friction nanogenerator and a heart disease detector and a preparation method thereof. The generator comprises a first friction layer, a second friction layer, a first electrode and a second electrode; by adjusting the composition of the same material, the electron gain and loss ability of the material is changed, the first friction layer and the second friction layer are made of the same material, and the composition of the material used by the first friction layer and the second friction layer is different, so that the electron gain and loss ability of the first friction layer and the second friction layer is different, thereby realizing electronic non-affinity friction nanogeneration, using the high sensitivity to pressure to extract the characteristic signal points of the pulse wave, realizing the function of self-powered single-point detection of human heart rate, diastolic pressure and systolic pressure; in addition, it is sensitive and high, and can detect the subtle changes of the pulse wave, and since the pulse wave of a patient with heart disease is different from the normal pulse wave, it can be applied to the preparation of a heart disease detector.

1. The name of the design product: heart rate monitoring brooch (magnolia flower). 2. The use of the design product: a brooch for wearing decoration and monitoring human heart rate, matched with a monitoring magnetic buckle. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

To provide a deployment tool intended to facilitate implantation of an implant, such as a prosthetic device (e.g., a prosthetic valve), at one of the native mitral, aortic, tricuspid, or pulmonary valve regions of a human heart.SOLUTION: The delivery catheter, in various embodiments, is configured to deliver the anchoring device to an annulus of a native valve of a patient's heart, where the anchoring device can better secure the prosthesis to the native valve annulus. The sheath catheter may be utilized to deliver the delivery catheter and the catheter for deploying the prosthetic valve to the anchor device.SELECTED DRAWING: Figure 27

The application discloses a test method for blasting vibration human response and perception quantitative evaluation, and relates to the technical field of blasting protection, comprising: carrying out field test of blasting vibration human response, and collecting soil vibration and human vibration response data; carrying out vibration table test of first field human vibration response under different vibration working conditions, and obtaining vibration table parameters for simulating field blasting vibration; establishing a human vibration response model; carrying out vibration table test of second field human vibration response under different vibration working conditions, and calculating average growth rate of human heart rate variability frequency domain index value; calculating and analyzing human vibration response data; establishing quantitative relationship between average growth rate of heart rate variability frequency domain index value and human subjective feeling; establishing relationship between blasting parameters and human comfort; and establishing blasting vibration human comfort partition, wherein the application can accurately evaluate human perception under different blasting working conditions.

The Cardiac Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.