79 results about "Valve prosthesis" patented technology

The invention relates to an intracavity implantation system which comprises an intracavity prosthesis, the intracavity prosthesis has a radial expansion state and a radial contraction state, the intracavity prosthesis comprises a covered stent, a valve prosthesis and a flexible connecting pipe, the covered stent is of a tubular structure and comprises a main body section and a reducing section which are communicated with each other, and the valve prosthesis is arranged in the main body section. The main body section and the reducing section are arranged in the axial direction of the covered stent, the cross section area of the near end of the reducing section is smaller than that of the far end of the reducing section, the covered stent is further provided with a window penetrating through the side wall of the covered stent, and at least part of the area of the window is located in the reducing section; the valve prosthesis comprises a valve support and an artificial valve leaflet connected to the interior of the valve support. The flexible connecting pipe is of a tubular structure defined by a flexible film, the far end of the flexible connecting pipe is connected with the reducing section, the near end of the flexible connecting pipe is connected with the valve prosthesis, and the two axial ends of the flexible connecting pipe are communicated with the covered stent and the valve prosthesis respectively. In the implanting process of the endoluminal prosthesis, the relative position of the valve prosthesis and the covered stent can be adjusted according to the lumen structure, and the endoluminal prosthesis can better adapt to various lumen structures. In addition, due to the arrangement of the flexible connecting pipe, the risk that the far end of the valve prosthesis is driven to expand and deform due to expansion of the covered stent can be reduced, force generated in the expansion process of the valve prosthesis is not prone to being transmitted to the covered stent, and therefore the risk that coronary blood flow is blocked due to expansion of the near end of the covered stent can be reduced.

A valve prosthesis includes a self-expanding frame and a prosthetic valve coupled to an interior of the frame. The frame includes a plurality of endcrowns at a first end thereof, and a first paddle connected to a first endcrown by a first stem. The first end of the frame is collapsible to a collapsed configuration when a restraining force is applied to the first paddle and to the endcrowns, is configured to expand from the collapsed configuration to a partially deployed configuration when the restraining force is removed from the endcrowns but is still applied to the first paddle, and is configured to expand to a fully deployed configuration when the restraining force is removed from the endcrowns and from the first paddle. A first vale of a lateral dimension of the first end in the partially deployed configuration is at least 70 percent of a second value of the lateral dimension of the first end in the fully deployed configuration.

The application provides a heart valve prosthesis and a preparation method thereof, the heart valve prosthesis comprising a stent and an integrated valve, the integrated valve comprising artificial valve leaves and a skirt, and the integrated valve being fixed to the stent by sewing threads; the preparation method comprises the following steps: obtaining an integrated valve material, and sequentially subjecting the integrated valve material to cutting, pre-shaping and folding processes, and finally sewing the folded integrated valve material on the stent to obtain the heart valve prosthesis. The application can minimize the damage to the valve, increase the durability of the valve, simplify the sewing process, reduce the production cost and improve the production efficiency.

A capsule of a delivery system for a transcatheter heart valve prosthesis includes markers for rotationally orienting the capsule within a native valve. The capsule includes markers that are sized and located on the capsule such that when viewed in a cusp overlap viewing angle image, the markers indicate whether the capsule is in a desired rotational orientation. Methods for rotationally aligning a capsule of a delivery system containing a transcatheter heart valve prosthesis within a native valve are also provided.

The invention provides a valve prosthesis which comprises a support, a valve leaflet and a skirt, the valve prosthesis comprises an inflow end and an outflow end, the support has a compressed state and an expanded state, the valve leaflet comprises at least two valve leaflet structures, each valve leaflet structure comprises a valve angle, and the adjacent valve leaflet structures are connected through the valve angles.

The invention provides a delivery system. The delivery system comprises a sheath tube, a sheath core and a sheath core connector, the sheath core is nested in an inner cavity of the sheath tube, and the sheath core comprises a sheath core main body tube and two reference wires which are symmetrical about the center of the sheath core; the sheath core connector is arranged on the sheath core in a sleeving mode and comprises a fixing part at the near end and a rotating part at the far end, the fixing part is fixedly arranged on the sheath core body tube, and the rotating part can rotate relative to the sheath core. According to the conveying system, before the valve prosthesis is loaded into the sheathing canal, the sheath core connector rotating part can be rotated to circumferentially adjust the valve prosthesis to the optimal position, it is ensured that after the valve prosthesis is conveyed to the designated position, the connection part of the valve prosthesis is aligned with connection of a native aortic valve, and the release accuracy is improved.

This invention discloses a valve prosthesis, including an inflow end and an outflow end. The valve prosthesis includes a support, a seal, and a cover. The cover at least covers the portion of the support near the inflow end. The seal includes a sealing material, a first fixing member, and a second fixing member. The sealing material includes a first side and a second side disposed opposite to each other. The first side or its vicinity is fixed to the cover with the first fixing member. Then, the second side is rolled or folded to approach the first side, forming an annular structure disposed on the outside of the cover. The second fixing member then fixes the annular structure to the cover. This invention provides a seal that is precisely positioned and shaped on the valve prosthesis support, thereby better adapting to the physiological environment in the body and greatly reducing the occurrence of paravalvular leakage.

The present invention relates to an atrioventricular heart valve prosthesis implantable, for example, into the heart of a mammal. The heart valve prosthesis comprises a collapsible-expandable tubular stent having a lumen, preferably having an opening cross-section or area during use or in a fully expanded state of the stent that is smaller than an opening area of a native atrioventricular heart valve to be replaced by the heart valve prosthesis. The heart valve prosthesis further includes an inner valve tip disposed within the lumen of the tubular stent that closes the heart valve by resting against each other, an outer valve leaflet that closes against the native valve leaflet, and at least one anchor wire connected directly or indirectly to the tubular stent. The invention also relates to a method for manufacturing a heart valve prosthesis and to a method for inserting a heart valve prosthesis.

This invention provides a valve prosthesis, comprising: a valve stent, leaflets, and a leaflet connector; the valve stent has a support rod; the leaflet connector includes a folded portion and a connecting portion, the folded portion being used to fold and accommodate the support rod; the connecting portion extends from both ends of the folded portion, and the connecting portion connects to the leaflet, such that the leaflet is connected to the support rod through the leaflet connector. This design improves the leaflet closure and the connection stability between the leaflet and the valve stent, thereby enhancing the overall stability of the valve prosthesis under complex operating conditions.

The application relates to the technical field of medical devices, and discloses a leaflet structure, a preparation method of the leaflet structure and a valve prosthesis. The leaflet structure comprises a leaflet body, the leaflet body comprises a fixed end, a free end and a side wall, the side wall extends from the fixed end to the free end, and the hydrophobicity of the side wall in the region close to the fixed end is greater than the hydrophobicity of the side wall in the region close to the free end. According to the leaflet structure, the hydrophobicity of the side wall close to the fixed end is designed to be greater than the hydrophobicity close to the free end, so that a humidity gradient effect is formed on the side wall, the leaflet body has the function of guiding fluid (i.e. blood) from one side close to the fixed end to one side close to the free end, the probability of blood deposition in the semi-closed region of the leaflet is reduced, and the service life of the leaflet structure is prolonged.

A dry valve crimping and loading system includes packaging, a crimper disposed in the packaging, and a dry valve prosthesis disposed within a crimper chamber of the crimper. The crimper chamber has a first volume in an expanded state a second volume in a collapsed state, wherein the first volume is greater than the second volume. The crimper is configured to transition the dry valve prosthesis from an uncompressed state to a compressed state when the crimper chamber transitions from the expanded state to the collapsed state to expel the glycerol from the dry valve prosthesis as the crimper transitions the dry valve prosthesis from the uncompressed state to the compressed state.

The application discloses an anchoring hook, a valve stent and a valve prosthesis. The anchoring hook body comprises a straight rod segment, a bending segment and a free segment arranged in sequence from a root to a head. A slit has a starting point in the root area of the straight rod segment, and the slit extends from the starting point along the length direction of the anchoring hook body through the straight rod segment, the bending segment and at least a part of the free segment. The slit penetrates the anchoring hook body in the thickness direction of the anchoring hook body, and the width of the slit in the width direction of the anchoring hook body satisfies that the bending stiffness of the anchoring hook body changes within a predetermined threshold range compared with that before the slit is formed. The anchoring hook in the application is slit on the body, and the slit can enhance the torsional compliance of the whole anchoring hook without affecting the bending stiffness of the anchoring hook body. When subjected to multi-dimensional interaction force caused by continuous contraction of the heart or subjected to torsional force that makes the anchoring hook have a lateral bending or torsional tendency, the anchoring hook in the application has good fatigue performance.

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and / or improved means for positioning the replacement heart valve. A heart valve prosthesis is provided with a stent and at least one locator. The locator has an adapted design for positioning within a cusp of the native aortic valve for implantation at the native heart valve site. Placement of the locators within the cusps preferably prevents movement from the native heart valve site post-implantation, including proximal movement of the prosthesis into the left ventricle.

The invention provides a heart implant, a delivery assembly and a heart implant system.The heart implant comprises a valve prosthesis and an anchoring nail, the anchoring nail can nail the valve prosthesis on a native tissue of an atrioventricular valve, on one hand, anchoring of the valve prosthesis in the heart is achieved, the problems of falling, shifting, twisting and the like of the valve prosthesis are avoided, and the heart implant delivery efficiency is improved; on the other hand, the compression of the valve prosthesis on the native tissue of the heart is greatly reduced so as to solve a series of problems such as ventricular structure remodeling caused by the valve prosthesis anchored through radial force, and on the other hand, the fitting gap between the valve prosthesis and the native tissue can be reduced, the sealing performance of the perivalvular is improved, the perivalvular leakage is reduced, and the heart safety is improved. On the other hand, when the valve prosthesis is nailed on the valve ring of the atrioventricular valve through the anchoring nail, the valve prosthesis is allowed to have a small axial height, and therefore the height of the valve prosthesis below the valve is reduced, and blocking of the valve prosthesis to blood entering the ventricular outflow tract is reduced.

This invention provides a transcatheter valve prosthesis comprising a stent, a prosthetic valve component, and a paravalvular leakage prevention component. The paravalvular leakage prevention component is coupled to the stent and includes an inner skirt, an outer covering, a lumen, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer covering surrounds an outer surface of the stent and has an inflow end and a downstream end, the inflow end being coupled to the inflow end of the inner skirt. The lumen is formed between the outer surface of the inner skirt and the inner surface of the outer covering. The opening is disposed between the inner skirt and the outer covering. The one-way valve includes a flap at the opening, the flap being configured to open to allow blood to flow into the lumen but prevent blood from flowing out of the lumen.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

The present application relates to the technical field of medical devices, and provides a valve prosthesis, comprising a stent and a bag body arranged on the stent. The stent comprises an extension body that can be located on one side of a cardiac valve annulus, and the side of the extension body opposite to the cardiac valve annulus is an outer side. The bag body is located on the outer side of the extension body. The bag body is provided with an opening that allows blood to enter. By means of the technical solutions of the present application, the valve prosthesis can better fit the cardiac valve annulus, thereby solving the problem of perivalvular leakage.

This invention relates to a valve prosthesis, which includes a support body and an elastic element disposed outside the support body. The support body has a through-hole, and the elastic element is arranged circumferentially around the support body, forming an annular cavity structure with the support body. The through-hole communicates with the annular cavity structure. Thus, by providing a through-hole in the support body, the through-hole communicates with the semi-closed structure, allowing blood flow within the semi-closed structure to flow out through the through-hole, preventing blood from stagnating within the semi-closed structure and forming a thrombus, thus promoting smooth blood flow. Furthermore, blood flow in the opposite direction can flow into the elastic element, where it is buffered, preventing blood from directly overflowing from the sidewall of the stent due to the through-hole in the inner fabric, thus avoiding paravalvular leakage.

A replacement heart valve prosthesis is loaded onto a balloon mounted onto a balloon shaft of a catheter system. The balloon shaft is rotatably engaged with an actuator on the handle of the catheter system. Rotation of the actuator by a first amount in a first direction permits rotation of the heart valve prosthesis by a known amount during the procedure so that alignment of the commissures of the replacement valve with the commissures of the existing valve can be predictably achieved.

The invention provides a valve replacement system which is used for replacing a native atrioventricular valve and comprises a butt joint device, an anchoring device and a valve prosthesis. The docking device is configured to be positioned through the anchoring and locking device and provide an accommodating cavity; the anchoring and locking device comprises a plurality of anchoring pieces, a plurality of locking pieces and a plurality of flexible linear pieces, wherein the number of the locking pieces is the same as that of the anchoring pieces, and the number of the flexible linear pieces is the same as that of the anchoring pieces. In the deployment completion state, one end of a linear piece is correspondingly and fixedly connected with an anchoring piece, and the other end of the linear piece penetrates through the butt joint device and then is correspondingly and fixedly connected with a locking piece; at least one anchoring piece is anchored into ventricular tissue, and at least another anchoring piece is anchored into annulus tissue or atrial tissue; the linear piece is tensioned by the anchoring piece and the locking piece which are correspondingly located on the two opposite sides of the butt-joint device, so that the butt-joint device is pressed against the native valve ring to be positioned; the valve prosthesis is arranged in the containing cavity of the butt joint device in a penetrating mode and is reliably fixed by the butt joint device.

The present invention relates to an endovascular implant system, comprising an endovascular prosthesis, which has a radially expanded state and a radially contracted state. The endovascular prosthesis comprises: a covered stent, a valve prosthesis and a flexible connecting tube. The covered stent has a tubular structure and comprises a main body section and a reduced-diameter section which are in communication with each other, wherein the main body section and the reduced-diameter section are arranged in the axial direction of the covered stent, and the cross-sectional area of a proximal end of the reduced-diameter section is smaller than that of a distal end of the reduced-diameter section. The covered stent is further provided with a window running through the side wall of the covered stent, the window being at least partially located in the reduced-diameter section. The valve prosthesis comprises a valve stent and prosthetic valve leaflets connected to the inside of the valve stent. The flexible connecting tube is of a tubular structure formed by a flexible membrane, wherein a distal end of the flexible connecting tube is connected to the reduced-diameter section, a proximal end of the flexible connecting tube is connected to the valve prosthesis, and two axial ends of the flexible connecting tube are respectively in communication with the covered stent and the valve prosthesis. During implantation of the endovascular prosthesis of the present invention, the relative positions of the valve prosthesis and the covered stent can be adjusted on the basis of a lumen structure, such that the endovascular prosthesis can better adapt to a variety of lumen structures. In addition, the provision of the flexible connecting tube can reduce the risk of expansion deformation of the distal end of the valve prosthesis caused by the expansion of the covered stent, and force generated by the valve prosthesis during expansion is not easily transmitted to the covered stent, thereby reducing the risk of obstruction of coronary blood flow caused by expansion of the proximal end of the covered stent.

The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.

This invention relates to the field of medical device technology, and more particularly to an absorbable valve stent and a valve prosthesis including the absorbable valve stent. The absorbable valve stent includes an inner stent and an outer stent disposed on the outer periphery of the inner stent. The outer stent includes a main body segment and a valve annulus segment connected together. The main body segment is used to match the atrium, and the valve annulus segment is used to match the valve annulus. The bottom of the valve annulus segment is connected to the bottom of the inner stent via a connecting frame. The main body segment is composed of a first rod, which is either a non-fully absorbable rod or entirely made of a biodegradable absorbable material. The non-fully absorbable rod includes an inner core made of a non-biodegradable absorbable material and an outer sheath made of a biodegradable absorbable material that wraps around the inner core. After implantation, the support force of the main body segment on the atrium is weakened by the degradation and absorption of the outer sheath, or the support of the atrium is relieved by the complete degradation and absorption of the main body segment, allowing the atrium to restore normal contractility.

A delivery system for delivering a heart valve prosthesis includes a delivery catheter and a heart valve prosthesis. The delivery catheter includes a retainer comprising a pocket. The heart valve prosthesis includes a frame and a connector extending from an end of the frame. The connector is disposed in the pocket of the retainer to couple the heart valve prosthesis to the delivery catheter. The pocket and the connector are configured to prevent hang-up of the connector in the pocket such as to improve release of the connector from the pocket of the retainer.

A medical device for treating a heart valve insufficiency, with an endoprosthesis which can be introduced into a patient's body and expanded to secure a heart valve prosthesis in the patient's aorta. In an embodiment, the endoprosthesis has a plurality of positioning arches configured to be positioned with respect to a patient's aorta and a plurality of retaining arches to support a heart valve prosthesis. The endoprosthesis includes a first collapsed mode during the process of introducing it into the patient's body and a second expanded mode when it is implanted.

A transcatheter valve prosthesis includes a stent and a prosthetic valve. The prosthetic valve is configured to substantially block blood flow in one direction to regulate blood flow through a central lumen of the stent. The stent includes an inflow portion, an outflow portion, and a transition portion extending between the inflow portion and the outflow portion. The transition portion includes a plurality of axial frame members extending between the inflow portion and the outflow portion. Each axial frame member extends in an axial direction from a crown of the inflow portion to at least a crown of the outflow portion. Each axial frame member has a first end adjacent to the crown of the inflow portion, the first end having a reduced width relative to a width of a length of the axial frame member between the first end and the crown of the outflow portion.

The invention provides a valve prosthesis which comprises a support, a valve leaflet and a skirt, the support comprises a plurality of support rods, the valve leaflet comprises at least two valve leaflet structures, each valve leaflet structure comprises a valve angle, the adjacent valve leaflet structures are connected through the valve angles, the skirt at least covers the two adjacent support rods and the area between the two adjacent support rods, and the valve leaflet structures are connected through the valve angles. The adjacent support rods and areas form a valve angle fixing part, in the valve angle fixing part, at least the part, on the outflow end side, of the valve angle is located between the two adjacent support rods, and the outer circumferential face of at least the part, on the outflow end side, of the valve angle is fixedly connected with the inner circumferential face of the skirt between the two adjacent support rods in the radial direction; and the fatigue life of the valve is prolonged.

A valve prosthesis to be deployed within a native heart valve at a native heart valve annulus. The valve prosthesis including an expandable frame and a plurality of spaced anchors. The expandable frame includes a proximal end and a distal end and a longitudinal axis extending therethrough. The expandable frame collapses radially for delivery and expands radially upon deployment to an expanded configuration. The plurality of spaced anchors extend from the distal end of the frame towards the proximal end, each anchor formed with a free end, and each anchor being expandable from a collapsed anchor configuration to an expanded anchor configuration, wherein each of the anchors includes a foot angle of from 0 to 45 degrees relative to the longitudinal axis.