365 results about "Valve prosthesis" patented technology

A heart valve prosthesis for replacing a diseased native valve in a patient. The valve prosthesis includes a compressible and expandable frame structure and an anchor connected to an outer periphery of the frame structure. The anchor comprises a helical wire having a free end. The valve may further include a valve segment mounted within the frame structure and expanded with the frame structure. The frame structure may be configured for receiving a valve segment.

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

Transcatheter aortic valve prostheses for improving the cardiac function of a patient suffering from coronary artery disease. Transcatheter aortic valve prostheses include a valve component and a frame. The valve component includes valve leaflets and a skirt. The frame includes access cells that improve access to a patient's coronary arteries if further intervention is required and / or includes a window or conduction protection cell that is oriented to align with a portion of conduction system of the heart in situ to reduce conduction disturbances of the anatomy. Suture patterns for attaching a commissure to a commissure post of the frame, and for attaching a tissue bumper to the commissure post, are also described.

A method of delivering and deploying a valve prosthesis includes delivering the valve prosthesis disposed in a delivery catheter to a native valve, proximally retracting a delivery catheter tube of the delivery catheter such that three engagement arms of a support of the valve prosthesis are released from the delivery catheter tube and flare outwardly while an inflow frame portion of the support remains within a distal portion of the delivery catheter, and distally advancing the distal portion of the delivery catheter such that the inflow frame portion is released from the distal portion.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

Delivery systems, devices, and methods for delivering a valve prosthesis to a native valve annulus are provided. The valve prosthesis may be secured to the native valve via an anchor that encircles the native valve annulus and the valve prosthesis. The anchor may be deployed around the chordae tendinea and / or leaflets of the native valve. A tether may be connected to the anchor and extend outside of the patient's body to maintain communication with the anchor. After the anchor is deployed, a guidewire may be advanced through the patient's vessels parallel to the tether and through the native valve annulus. A valve delivery catheter carrying the valve prosthesis may be advanced over the guidewire and into the native valve annulus where the valve prosthesis is released and deployed. The tether may be used to position the anchor and / or valve prosthesis during one or more operations of the valve delivery process.

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

A transcatheter heart valve prosthesis is disclosed that includes a tubular frame, which defines a central lumen of the prosthesis, and a tubular valve-skirt subassembly disposed within the central lumen. The valve-skirt subassembly includes a skirt element and a valve component having a plurality of leaflets. Each leaflet of the plurality of leaflets is formed to have a first commissure tab and a second commissure tab disposed at opposing lateral ends of the leaflet. The first commissure tab of a respective leaflet, in a folded state, forms a first commissure of the respective leaflet that is directly coupled only to the skirt element of the valve-skirt subassembly, and the second commissure tab of the respective leaflet, in a folded state, forms a second commissure of the respective leaflet that is directly coupled only to the skirt element of the valve-skirt subassembly.

Devices and methods for delivering one or more portions of a valve prosthesis into the heart of a patient. The device may include one or more catheters operably coupled to one or more controls for controlling axial movement, rotational movement, and / or deflection of the one or more catheters during delivery of the valve prosthesis to the heart. The one or more controls may provide coarse and fine motion control of multiple degrees of freedom of the one or more catheters, thereby providing better control to physicians during valve prosthesis delivery procedures.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments. The segments may be orthogonal or oblique to the outer surface of the tubular stent.

A prosthetic valve component is disclosed for a valve prosthesis. The valve component includes valve leaflets configured to be operably coupled within a frame of the valve prosthesis, wherein each valve leaflet is shaped and sized to achieve a target pinwheeling score PS. The target pinwheeling score correlates to full contact being made between free edges of the valve leaflets, when the valve leaflets are operably coupled within the frame of the valve prosthesis, such that no central opening and little to no overlap occurs between the valve leaflets.

A heart valve prosthesis is positioned within an index valve prosthesis. The heart valve prosthesis includes an annular frame extending along a valve axis between a first valve end and a second valve end. The annular frame includes a plurality of frame members and is adjustable between a radially-collapsed configuration and a radially- expanded configuration. The annular frame includes a central region including a folded segment that moves between a first configuration and a second configuration. The folded segment is biased toward the second configuration. The folded segment defines a channel on an outer radial side of the folded segment when the folded segment is in the second configuration. The channel receives at least one lacerated leaflet of the index valve prosthesis. Methods of implanting a heart valve prosthesis are provided.

The invention relates to the field of medical instruments, in particular to an artificial valve prosthesis replacement system which comprises a valve support and a conveying system used for conveying the valve support, and a valve leaflet clamping mechanism and an anchoring ring connected with the valve leaflet clamping mechanism are arranged on the valve support. The conveying system comprises an outer sheath tube, an inner core tube, a control wire and a connecting mechanism, the connecting mechanism comprises a connecting piece and a protection piece arranged at the far end of the connecting piece, the far end of the inner core tube is fixedly connected with the connecting piece, and the valve leaflet clamping mechanism is detachably connected with the connecting mechanism through the control wire; according to the scheme, the connecting mechanism is matched with the control wire, so that the conveying instrument and the valve support are of a stable and controllable detachable structure, opening and closing of the clamping arms can be controlled, the loading pipe diameter can be reduced, recycling is achieved, intracardiac adjustment is facilitated, and good clinical significance is achieved.

A heart valve prosthesis comprising a radially expandable and compressible annular frame is disclosed. The frame comprises a plurality of interconnected rows of cells disposed between an inflow end and an outflow end of the frame, the interconnected rows of cells comprising a plurality of outflow struts defining the outflow end and a plurality of inflow struts defining the inflow end. The frame further comprises a plurality of tip regions formed at the inflow end and the outflow end, each tip region curved between two angled strut portions and forming one of the outflow struts or one of the inflow struts with the two angled strut portions.Each tip region has a reduced width and a length extending at least 25% of the total length of the outflow strut or the inflow strut, the reduced width being less than the width of the two angled strut sections.

The invention discloses a valve prosthesis which comprises an inflow end and an outflow end, the valve prosthesis comprises a support, a sealing piece and a covering film, the covering film at least covers the part, close to the inflow end, of the support, the sealing piece comprises a sealing material, a first fixing piece and a second fixing piece, and the sealing material comprises a first edge and a second edge which are oppositely arranged; the first edge or an area near the first edge is fixed with the covering film through the first fixing piece, then the second edge is close to the first edge in a rolling or folding mode to form an annular structure arranged on the outer side of the covering film, and then the annular structure and the covering film are fixed through the second fixing piece, so that the sealing piece which is accurately positioned and shaped on the valve prosthesis support can be obtained. Therefore, the perivalvular leakage prevention device can better adapt to the in-vivo physiological environment, and the perivalvular leakage situation is greatly reduced.

The invention relates to an intracavity implantation system which comprises an intracavity prosthesis, the intracavity prosthesis has a radial expansion state and a radial contraction state, the intracavity prosthesis comprises a covered stent, a valve prosthesis and a flexible connecting pipe, the covered stent is of a tubular structure and comprises a main body section and a reducing section which are communicated with each other, and the valve prosthesis is arranged in the main body section. The main body section and the reducing section are arranged in the axial direction of the covered stent, the cross section area of the near end of the reducing section is smaller than that of the far end of the reducing section, the covered stent is further provided with a window penetrating through the side wall of the covered stent, and at least part of the area of the window is located in the reducing section; the valve prosthesis comprises a valve support and an artificial valve leaflet connected to the interior of the valve support. The flexible connecting pipe is of a tubular structure defined by a flexible film, the far end of the flexible connecting pipe is connected with the reducing section, the near end of the flexible connecting pipe is connected with the valve prosthesis, and the two axial ends of the flexible connecting pipe are communicated with the covered stent and the valve prosthesis respectively. In the implanting process of the endoluminal prosthesis, the relative position of the valve prosthesis and the covered stent can be adjusted according to the lumen structure, and the endoluminal prosthesis can better adapt to various lumen structures. In addition, due to the arrangement of the flexible connecting pipe, the risk that the far end of the valve prosthesis is driven to expand and deform due to expansion of the covered stent can be reduced, force generated in the expansion process of the valve prosthesis is not prone to being transmitted to the covered stent, and therefore the risk that coronary blood flow is blocked due to expansion of the near end of the covered stent can be reduced.

The invention relates to the technical field of medical instruments, in particular to an assembling method for conveying a valve prosthesis, which is characterized in that a fixing mechanism is arranged, and a spiral blade is driven to rotate by rotating an adjusting ring, so that an inner hole formed in the spiral blade is shrunk to be clamped with an inner catheter; the bending between the inner catheter and the outer catheter is further locked, so that the situation that a worker always needs to manually lock the sheathing canal is avoided, the operation process is greatly simplified, and the operation difficulty is reduced.

A transcatheter valve prosthesis including a tubular stent, a prosthetic valve component disposed within and secured to the stent, and a centering mechanism coupled to and encircling an outer surface of the tubular stent. The centering mechanism includes a self-expanding centering ring having an expanded diameter in the expanded configuration that is greater than an expanded diameter of the tubular stent in the expanded configuration and a plurality of self-expanding spokes radially extending between the tubular stent and the centering ring. The centering mechanism may include a base ring and / or a skirt. Alternatively, the centering mechanism includes a plurality of self-expanding loops. When each loop is in a delivery configuration the loop has a straightened profile that proximally extends from a proximal end of the tubular stent. When each loop is in an expanded configuration the loop has a U-shaped profile radially spaced apart from the tubular stent.

A transcatheter valve prosthesis includes a stent having a radially compressed configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve. The stent includes an inflow portion, an outflow portion, and at least one commissure post extending between the inflow portion and the outflow portion. Inflow and / or outflow markers are positioned on the stent to enable longitudinal and rotational orientation of the stent during the installation at the implant location.

A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame defines a central channel that extends along a central axis. The flow control component is disposed within the central channel and coupled to the outer frame. The flow control component has a set of leaflets mounted within an inner frame. The prosthetic valve is configured to be folded along a longitudinal axis and compressed along the central axis to place the prosthetic valve in a compressed configuration for delivery via a delivery catheter. The longitudinal axis is substantially parallel to a lengthwise axis of the delivery catheter when disposed therein. The prosthetic valve transitions to an expanded configuration when released from the delivery catheter. The flow control component elastically deforms from a substantially cylindrical configuration to a substantially flattened configuration when the prosthetic valve is placed in the compressed configuration.

A valve prosthesis includes a self-expanding frame and a prosthetic valve coupled to an interior of the frame. The frame includes a plurality of endcrowns at a first end thereof, and a first paddle connected to a first endcrown by a first stem. The first end of the frame is collapsible to a collapsed configuration when a restraining force is applied to the first paddle and to the endcrowns, is configured to expand from the collapsed configuration to a partially deployed configuration when the restraining force is removed from the endcrowns but is still applied to the first paddle, and is configured to expand to a fully deployed configuration when the restraining force is removed from the endcrowns and from the first paddle. A first vale of a lateral dimension of the first end in the partially deployed configuration is at least 70 percent of a second value of the lateral dimension of the first end in the fully deployed configuration.

The invention provides a conveying assembly and a conveying system. The conveying assembly comprises a bending adjusting wire and a conveying pipe. The conveying pipe comprises a sheath pipe section and an outer pipe section, the sheath pipe section is located at the far end of the outer pipe section, the sheath pipe section wraps at least one part of the outer pipe section, and the sheath pipe section is used for wrapping the valve prosthesis; the bending adjusting wire is parallel to the axial direction of the conveying pipe and penetrates through the inner wall of the conveying pipe, and the bending adjusting wire is folded back at the far end of the sheath pipe section and used for driving the conveying pipe to be bent in the process of conveying the valve prosthesis. According to the configuration, the bending adjusting wire is arranged on the inner wall of the conveying pipe in a penetrating mode and is bent back at the far end of the sheathing canal section, so that the action point of the bending adjusting wire is located at the far end of the sheathing canal section, meanwhile, the sheathing canal section wraps the valve prosthesis, the axial distance between the action point of the bending adjusting wire and the valve prosthesis is shortened, and the coaxial effect of the valve prosthesis and the native valve ring is effectively guaranteed.

The invention relates to the technical field of medical instruments, and provides a supporting tube and a sheathing canal for an interventional operation, and the supporting tube for the interventional operation comprises a body section and an expandable section located at the far end of the body section; the expandable section comprises a plurality of through holes, the through holes located in the same row in the circumferential direction form a circumferential through hole group, and a plurality of rows of circumferential through hole groups are formed in the expandable section in the axial direction; and the sizes of the through holes in the plurality of rows of circumferential through hole groups are gradually reduced from the far end to the near end. According to the technical scheme, the problem of stress concentration of the sheathing canal in the process of releasing and recovering the valve prosthesis can be solved.

The invention discloses an aorta valved conduit with a coronary artery bridging vessel, comprising: an ascending aorta prosthesis comprising an ascending aorta stent; the valve prosthesis comprises a valve support and a valve blade, the valve support is coated with a valve covering film, and a bridging port used for bridging the coronary artery bridging blood vessel prosthesis or the coronary artery bridging blood vessel prosthesis communicated with the interior of the valve prosthesis is arranged on the valve covering film; the guide stent comprises at least one group of connecting rib units, the connecting rib units are connected with the ascending aorta stent and are arranged along the longitudinal direction of the ascending aorta stent, and one end of each connecting rib unit is connected with the valve stent so as to restrain the bending direction of the ascending aorta stent; the ascending aorta stent can only be bent along the plane where the connecting rib units and the central axis of the ascending aorta stent are located. The covering film is arranged outside the valve prosthesis in a covering mode, it is guaranteed that blood in the valve prosthesis cannot leak, and the coronary artery bridging blood vessel prosthesis is connected to the valve prosthesis so that the interior of the valve pipeline can be communicated with coronary artery blood flow.

The invention discloses an intrusive aorta valved conduit, comprising: an ascending aorta prosthesis comprising an ascending aorta stent, and an ascending aorta covering film covering the ascending aorta stent, so that the ascending aorta prosthesis can be adapted to the inner wall of the ascending aorta and form a sealing fit with the inner wall of the ascending aorta; the valve prosthesis comprises a valve support and a valve blade. Comprising at least one group of connecting rib units, the connecting rib units are connected with the ascending aorta stent and arranged in the longitudinal direction of the ascending aorta stent, and one ends of the connecting rib units are connected with the valve stent to restrain the bending direction of the ascending aorta stent; the ascending aorta stent can only be bent along the plane where the connecting rib units and the central axis of the ascending aorta stent are located. Through the arrangement of the connecting ribs, the angle of the valved pipeline in the input process can be controlled, so that the bending direction of the valved pipeline in the in-vivo conveying process is accurately controlled, the implantation angle of the instrument is convenient to adjust and control, the instrument can be accurately aligned with the boundary edge of a native valve leaflet, and the implantation precision of the valved pipeline is guaranteed.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

A partial valve prosthesis includes a framework configured for following a shape of a portion of the native valve annulus when implanted into the native valve annulus, the framework including securement features for anchoring the framework to an inner periphery of the native valve annulus and retaining at least one leaflet configured to replace a corresponding one of the plurality of native leaflets; and at least one leaflet secured to the framework. Additional embodiments and methods are disclosed.

The invention discloses a valve stent, a valve prosthesis and application of the valve stent and the valve prosthesis to preparation of medical instruments. The valve stent comprises an inner-layer stent body and an outer-layer stent body, the outer-layer stent body is of a hollow net-shaped structure with the two ends open and comprises an outer stent body and a woven structural part, the outer stent body comprises a main supporting part and a secondary supporting part which are sequentially connected in the axial direction, and the secondary supporting part is provided with a self-adaptive area; the woven structural part is fixed on the secondary supporting part and covers the self-adaptive area; the supporting strength of the woven structural part is smaller than that of the outer frame body. The inner-layer frame body is of a cylindrical structure with two open ends; the outer-layer frame body is arranged outside the inner-layer frame body in a sleeving manner and is fixedly connected with the inner-layer frame body. The valve support is stable in structure, and on the premise that a good radial supporting effect is kept, damage to native tissue of a patient is small.

The present invention provides a valve stent and a valve prosthesis, wherein the valve stent is in a mesh tube shape, and comprises M layers of wave-rod unit groups connected in sequence along the axial direction, wherein the first layer of wave-rod unit groups is located at the inflow end, and the Mth layer of wave-rod unit groups is located at the outflow end, wherein the wave-rod unit groups comprise circumferentially connected wave-rod units, and the number of wave-rod units in the Mth layer of wave-rod unit groups is less than the number of wave-rod units in the M-1st layer of wave-rod unit groups. The present invention can solve the problem that the existing valve stent squeezes the valve leaflets during use, thereby causing the valve leaflets to block the coronary channel.

The present invention discloses an artificial valve prosthesis, comprising a stent body and a leaflet assembly. The stent body includes a first stent and a second stent. The first stent has a connection end. Wherein, the second stent includes a plurality of stent rods, and the plurality of stent rods are respectively fixed to the connection end of the first stent. The leaflet assembly has a first leaflet fixing portion, and the leaflet assembly is fixed to the connection end of the first stent through the first leaflet fixing portion. Compared with the prior art framework structure composed of a plurality of closed geometric units, the second stent of the present invention is mainly composed of a plurality of stent rods, reducing the material of the stent body of the present invention, thereby reducing the cross-sectional area of the delivery device, and thus reducing the trauma area of the patient; in addition, the stent structure in the area sandwiched between the leaflet assembly and the second stent is relatively sparse, and blood is not easily deposited there, thus reducing the risk of thrombus formation.