153 results about "Valve prosthesis" patented technology

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

A heart valve prosthesis comprising a radially expandable and compressible annular frame is disclosed. The frame comprises a plurality of interconnected rows of cells disposed between an inflow end and an outflow end of the frame, the interconnected rows of cells comprising a plurality of outflow struts defining the outflow end and a plurality of inflow struts defining the inflow end. The frame further comprises a plurality of tip regions formed at the inflow end and the outflow end, each tip region curved between two angled strut portions and forming one of the outflow struts or one of the inflow struts with the two angled strut portions.Each tip region has a reduced width and a length extending at least 25% of the total length of the outflow strut or the inflow strut, the reduced width being less than the width of the two angled strut sections.

The invention relates to an intracavity implantation system which comprises an intracavity prosthesis, the intracavity prosthesis has a radial expansion state and a radial contraction state, the intracavity prosthesis comprises a covered stent, a valve prosthesis and a flexible connecting pipe, the covered stent is of a tubular structure and comprises a main body section and a reducing section which are communicated with each other, and the valve prosthesis is arranged in the main body section. The main body section and the reducing section are arranged in the axial direction of the covered stent, the cross section area of the near end of the reducing section is smaller than that of the far end of the reducing section, the covered stent is further provided with a window penetrating through the side wall of the covered stent, and at least part of the area of the window is located in the reducing section; the valve prosthesis comprises a valve support and an artificial valve leaflet connected to the interior of the valve support. The flexible connecting pipe is of a tubular structure defined by a flexible film, the far end of the flexible connecting pipe is connected with the reducing section, the near end of the flexible connecting pipe is connected with the valve prosthesis, and the two axial ends of the flexible connecting pipe are communicated with the covered stent and the valve prosthesis respectively. In the implanting process of the endoluminal prosthesis, the relative position of the valve prosthesis and the covered stent can be adjusted according to the lumen structure, and the endoluminal prosthesis can better adapt to various lumen structures. In addition, due to the arrangement of the flexible connecting pipe, the risk that the far end of the valve prosthesis is driven to expand and deform due to expansion of the covered stent can be reduced, force generated in the expansion process of the valve prosthesis is not prone to being transmitted to the covered stent, and therefore the risk that coronary blood flow is blocked due to expansion of the near end of the covered stent can be reduced.

A valve prosthesis includes a self-expanding frame and a prosthetic valve coupled to an interior of the frame. The frame includes a plurality of endcrowns at a first end thereof, and a first paddle connected to a first endcrown by a first stem. The first end of the frame is collapsible to a collapsed configuration when a restraining force is applied to the first paddle and to the endcrowns, is configured to expand from the collapsed configuration to a partially deployed configuration when the restraining force is removed from the endcrowns but is still applied to the first paddle, and is configured to expand to a fully deployed configuration when the restraining force is removed from the endcrowns and from the first paddle. A first vale of a lateral dimension of the first end in the partially deployed configuration is at least 70 percent of a second value of the lateral dimension of the first end in the fully deployed configuration.

The invention relates to a valve prosthesis which comprises a stent body and a valve leaflet, the stent body comprises an outflow end and an inflow end, the stent body comprises an inner stent and an outer stent, the inner stent is arranged in the outer stent, the valve leaflet is arranged in the inner stent, and the outflow end comprises a plurality of connecting points. The outer-layer stent and the inner-layer stent are connected with the connecting points after being connected at the outflow end or at the position close to the outflow end, a circle is defined by the multiple connecting points, the circle is provided with a circumference, the circumference is equally divided by the multiple connecting points, on one hand, it can be guaranteed that the outflow end of the stent body is of a symmetrical structure, and the stent body can be evenly compressed into a conveying sheath tube; on the other hand, it can be guaranteed that the stent body is evenly stressed when placed at the lesion position, and therefore the stent body is not prone to falling off.

The application provides a heart valve prosthesis and a preparation method thereof, the heart valve prosthesis comprising a stent and an integrated valve, the integrated valve comprising artificial valve leaves and a skirt, and the integrated valve being fixed to the stent by sewing threads; the preparation method comprises the following steps: obtaining an integrated valve material, and sequentially subjecting the integrated valve material to cutting, pre-shaping and folding processes, and finally sewing the folded integrated valve material on the stent to obtain the heart valve prosthesis. The application can minimize the damage to the valve, increase the durability of the valve, simplify the sewing process, reduce the production cost and improve the production efficiency.

A capsule of a delivery system for a transcatheter heart valve prosthesis includes markers for rotationally orienting the capsule within a native valve. The capsule includes markers that are sized and located on the capsule such that when viewed in a cusp overlap viewing angle image, the markers indicate whether the capsule is in a desired rotational orientation. Methods for rotationally aligning a capsule of a delivery system containing a transcatheter heart valve prosthesis within a native valve are also provided.

The invention provides a valve prosthesis which comprises a support, a valve leaflet and a skirt, the valve prosthesis comprises an inflow end and an outflow end, the support has a compressed state and an expanded state, the valve leaflet comprises at least two valve leaflet structures, each valve leaflet structure comprises a valve angle, and the adjacent valve leaflet structures are connected through the valve angles.

The invention provides a delivery system. The delivery system comprises a sheath tube, a sheath core and a sheath core connector, the sheath core is nested in an inner cavity of the sheath tube, and the sheath core comprises a sheath core main body tube and two reference wires which are symmetrical about the center of the sheath core; the sheath core connector is arranged on the sheath core in a sleeving mode and comprises a fixing part at the near end and a rotating part at the far end, the fixing part is fixedly arranged on the sheath core body tube, and the rotating part can rotate relative to the sheath core. According to the conveying system, before the valve prosthesis is loaded into the sheathing canal, the sheath core connector rotating part can be rotated to circumferentially adjust the valve prosthesis to the optimal position, it is ensured that after the valve prosthesis is conveyed to the designated position, the connection part of the valve prosthesis is aligned with connection of a native aortic valve, and the release accuracy is improved.

The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall. In the third state, the second clamping member protrudes from the first clamping member and extends in a circumferential direction of the frame body and abuts against an outer surface of the frame body, so that an autologous valve leaflet and adjacent tissues are capable of being clamped between the second clamping member, the first clamping member, and the frame body. The contact area between the valve prosthesis and the autologous tissues can be increased, the position stability of the valve prosthesis in the heart can be improved, and the success rate of the operation can be increased.

This invention discloses a valve prosthesis, including an inflow end and an outflow end. The valve prosthesis includes a support, a seal, and a cover. The cover at least covers the portion of the support near the inflow end. The seal includes a sealing material, a first fixing member, and a second fixing member. The sealing material includes a first side and a second side disposed opposite to each other. The first side or its vicinity is fixed to the cover with the first fixing member. Then, the second side is rolled or folded to approach the first side, forming an annular structure disposed on the outside of the cover. The second fixing member then fixes the annular structure to the cover. This invention provides a seal that is precisely positioned and shaped on the valve prosthesis support, thereby better adapting to the physiological environment in the body and greatly reducing the occurrence of paravalvular leakage.

The present invention relates to an atrioventricular heart valve prosthesis implantable, for example, into the heart of a mammal. The heart valve prosthesis comprises a collapsible-expandable tubular stent having a lumen, preferably having an opening cross-section or area during use or in a fully expanded state of the stent that is smaller than an opening area of a native atrioventricular heart valve to be replaced by the heart valve prosthesis. The heart valve prosthesis further includes an inner valve tip disposed within the lumen of the tubular stent that closes the heart valve by resting against each other, an outer valve leaflet that closes against the native valve leaflet, and at least one anchor wire connected directly or indirectly to the tubular stent. The invention also relates to a method for manufacturing a heart valve prosthesis and to a method for inserting a heart valve prosthesis.

This invention relates to a valve prosthesis and a stent, the stent comprising a first stent. The first stent includes two first rod groups, and a first axial rod and a second axial rod connecting the two first rod groups and arranged along the axial direction of the stent. Each first rod group includes a plurality of first rods connected end-to-end and arranged in a W-shape. The first crests of the two first rod groups are arranged opposite each other, and the first troughs are arranged opposite each other. At least one or more of the two oppositely arranged first crests are connected by one or more first axial rods, and the two oppositely arranged first troughs are connected by one or more second axial rods. In this way, the arrangement density of the axial rods can be increased, thereby improving the radial support strength, so that it can be stably fixed at the location of the original valve; in addition, the enclosed quadrilateral structure can be easily bent under stress, that is, it will not affect the normal storage and folding of the stent.

This invention provides a valve prosthesis, comprising: a valve stent, leaflets, and a leaflet connector; the valve stent has a support rod; the leaflet connector includes a folded portion and a connecting portion, the folded portion being used to fold and accommodate the support rod; the connecting portion extends from both ends of the folded portion, and the connecting portion connects to the leaflet, such that the leaflet is connected to the support rod through the leaflet connector. This design improves the leaflet closure and the connection stability between the leaflet and the valve stent, thereby enhancing the overall stability of the valve prosthesis under complex operating conditions.

The application relates to the technical field of medical devices, and discloses a leaflet structure, a preparation method of the leaflet structure and a valve prosthesis. The leaflet structure comprises a leaflet body, the leaflet body comprises a fixed end, a free end and a side wall, the side wall extends from the fixed end to the free end, and the hydrophobicity of the side wall in the region close to the fixed end is greater than the hydrophobicity of the side wall in the region close to the free end. According to the leaflet structure, the hydrophobicity of the side wall close to the fixed end is designed to be greater than the hydrophobicity close to the free end, so that a humidity gradient effect is formed on the side wall, the leaflet body has the function of guiding fluid (i.e. blood) from one side close to the fixed end to one side close to the free end, the probability of blood deposition in the semi-closed region of the leaflet is reduced, and the service life of the leaflet structure is prolonged.

A dry valve crimping and loading system includes packaging, a crimper disposed in the packaging, and a dry valve prosthesis disposed within a crimper chamber of the crimper. The crimper chamber has a first volume in an expanded state a second volume in a collapsed state, wherein the first volume is greater than the second volume. The crimper is configured to transition the dry valve prosthesis from an uncompressed state to a compressed state when the crimper chamber transitions from the expanded state to the collapsed state to expel the glycerol from the dry valve prosthesis as the crimper transitions the dry valve prosthesis from the uncompressed state to the compressed state.

The application discloses an anchoring hook, a valve stent and a valve prosthesis. The anchoring hook body comprises a straight rod segment, a bending segment and a free segment arranged in sequence from a root to a head. A slit has a starting point in the root area of the straight rod segment, and the slit extends from the starting point along the length direction of the anchoring hook body through the straight rod segment, the bending segment and at least a part of the free segment. The slit penetrates the anchoring hook body in the thickness direction of the anchoring hook body, and the width of the slit in the width direction of the anchoring hook body satisfies that the bending stiffness of the anchoring hook body changes within a predetermined threshold range compared with that before the slit is formed. The anchoring hook in the application is slit on the body, and the slit can enhance the torsional compliance of the whole anchoring hook without affecting the bending stiffness of the anchoring hook body. When subjected to multi-dimensional interaction force caused by continuous contraction of the heart or subjected to torsional force that makes the anchoring hook have a lateral bending or torsional tendency, the anchoring hook in the application has good fatigue performance.

A heart valve prosthesis is positioned within an index valve prosthesis. The heart valve prosthesis includes an annular frame extending along a valve axis between a first valve end and a second valve end. The annular frame includes a plurality of frame members and is adjustable between a radially-collapsed configuration and a radially-expanded configuration. The annular frame includes an engagement region extending circumferentially around the valve axis and includes at least one protrusion arm extending radially outwardly. At least one anchor is attached to the at least one protrusion arm and contacts at least one lacerated leaflet of the index valve prosthesis and moves the at least one lacerated leaflet to a position that does not obstruct a coronary artery. Methods of implanting a heart valve prosthesis are provided.

The invention relates to a method for reducing biological heart valve prosthesis calcification by adopting a titanium-containing coating in combination with ultraviolet irradiation. The invention relates to a method for treating a biological heart valve prosthesis with a titanium-containing coating, in particular a glutaraldehyde-immobilized pericardium, comprising the following steps: a) treating a biological heart valve prosthesis with a titanium-containing coating; and b) irradiating the treated biological heart valve prosthesis with light having a wavelength of 100 to 450 nm. In this way, the biological heart valve prosthesis with the uniform surface can be manufactured through the hypothesized polymer, and therefore the biological heart valve prosthesis with the uniform surface can be manufactured through the hypothesized polymer. Calcification of such a TAVI valve is significantly reduced, the life of the TAVI valve is increased, which increases the time interval at which such a TAVI valve must be replaced over the years.

The application discloses a valve prosthesis, which comprises an inner layer support, an outer layer support and an elastic piece. The inner layer support is arranged in the outer layer support and connected with the outer layer support. The two ends of the elastic piece are connected with the outer layer support and the inner layer support respectively. The inflow end of the inner layer support and the outflow end of the outer layer support are connected, and the inner wall of the outer layer support and the outer wall of the inner layer support are arranged at intervals, so that a certain deformation space is formed between the outer layer support and the inner layer support. Therefore, when the outer layer support is extruded and deformed, the outer layer support can be deformed in the deformation space, and the probability that the leaflet assembly is affected by the extrusion of the outer layer support on the inner layer support is reduced.

The disclosure relates to heart valve prostheses with the reduced need of pacemaker implantation and / or improved means for positioning the replacement heart valve. A heart valve prosthesis is provided with a stent and at least one locator. The locator has an adapted design for positioning within a cusp of the native aortic valve for implantation at the native heart valve site. Placement of the locators within the cusps preferably prevents movement from the native heart valve site post-implantation, including proximal movement of the prosthesis into the left ventricle.

The invention provides a heart implant, a delivery assembly and a heart implant system.The heart implant comprises a valve prosthesis and an anchoring nail, the anchoring nail can nail the valve prosthesis on a native tissue of an atrioventricular valve, on one hand, anchoring of the valve prosthesis in the heart is achieved, the problems of falling, shifting, twisting and the like of the valve prosthesis are avoided, and the heart implant delivery efficiency is improved; on the other hand, the compression of the valve prosthesis on the native tissue of the heart is greatly reduced so as to solve a series of problems such as ventricular structure remodeling caused by the valve prosthesis anchored through radial force, and on the other hand, the fitting gap between the valve prosthesis and the native tissue can be reduced, the sealing performance of the perivalvular is improved, the perivalvular leakage is reduced, and the heart safety is improved. On the other hand, when the valve prosthesis is nailed on the valve ring of the atrioventricular valve through the anchoring nail, the valve prosthesis is allowed to have a small axial height, and therefore the height of the valve prosthesis below the valve is reduced, and blocking of the valve prosthesis to blood entering the ventricular outflow tract is reduced.

A heart valve prosthesis can be delivered within a native heart valve annulus using a delivery system that encases the heart valve prosthesis and sequentially permits expansion of a valve clasper and a lattice frame of the valve prosthesis. A sheath of the delivery system can be proximally retracted to permit the sinus locator to expand. Thereafter, a tubular member can be actuated to permit expansion of the lattice frame. Further, a clasper pusher of the delivery system, coupled to the tubular member, can be used to release a proximal portion of the sinus locator after release of the lattice frame. The delivery system can enable sinus locator engagement within the native annulus, sandwiching native valve leaflets between the expanded lattice frame and sinus locator, and thereafter permit disengagement of the sinus locator from the clasper pusher after the lattice frame expands.

The invention relates to a method to reduce the calcification of a biological heart valve prosthesis by a titanium containing coating in combination with UV irradiation. The method for treating the biological heart valve prosthesis with a titanium containing coating, particularly a glutaraldehyde-fixed pericardium, comprising the steps of: a) treating the biological heart valve prosthesis with a titanium containing coating; and b) irradiating the treated biological heart valve prosthesis with light of a wavelength between 100 nm and 450 nm. This results in a biological heart valve prosthesis by a hypothesized polymerization with a homogenous surface.

The present embodiments relate to systems and methods for treating luminal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of luminal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

This invention provides a transcatheter valve prosthesis comprising a stent, a prosthetic valve component, and a paravalvular leakage prevention component. The paravalvular leakage prevention component is coupled to the stent and includes an inner skirt, an outer covering, a lumen, an opening, and a one-way valve. The inner skirt is disposed on an inner surface of the stent and has an inflow end and a downstream end. The outer covering surrounds an outer surface of the stent and has an inflow end and a downstream end, the inflow end being coupled to the inflow end of the inner skirt. The lumen is formed between the outer surface of the inner skirt and the inner surface of the outer covering. The opening is disposed between the inner skirt and the outer covering. The one-way valve includes a flap at the opening, the flap being configured to open to allow blood to flow into the lumen but prevent blood from flowing out of the lumen.

A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.

The present application relates to the technical field of medical devices, and provides a valve prosthesis, comprising a stent and a bag body arranged on the stent. The stent comprises an extension body that can be located on one side of a cardiac valve annulus, and the side of the extension body opposite to the cardiac valve annulus is an outer side. The bag body is located on the outer side of the extension body. The bag body is provided with an opening that allows blood to enter. By means of the technical solutions of the present application, the valve prosthesis can better fit the cardiac valve annulus, thereby solving the problem of perivalvular leakage.

This invention relates to a valve prosthesis, which includes a support body and an elastic element disposed outside the support body. The support body has a through-hole, and the elastic element is arranged circumferentially around the support body, forming an annular cavity structure with the support body. The through-hole communicates with the annular cavity structure. Thus, by providing a through-hole in the support body, the through-hole communicates with the semi-closed structure, allowing blood flow within the semi-closed structure to flow out through the through-hole, preventing blood from stagnating within the semi-closed structure and forming a thrombus, thus promoting smooth blood flow. Furthermore, blood flow in the opposite direction can flow into the elastic element, where it is buffered, preventing blood from directly overflowing from the sidewall of the stent due to the through-hole in the inner fabric, thus avoiding paravalvular leakage.

The invention relates to a tricuspid regurgitation control device for an orthogonal transcatheter heart valve prosthesis. The invention also relates to access and occluder devices, in particular heart valve regurgitation drums and optionally closure discs and / or tubular stents, for managing and providing intentional regurgitation levels within transcatheter heart valve substitutes and in particular orthogonally delivered transcatheter prosthetic heart valves, an orthogonal delivery transcatheter prosthetic heart valve has a first inner flow control member / valve, a second inner reflux control member, and an outer annular support frame with a compressible wire unit that facilitates flat folding along the z-axis and compression of the valve vertically along the y-axis or orthogonal to the central axis of the flow control member, the present invention relates to a valvular delivery and deployment system, in particular to a valvular delivery and deployment system, which allows delivery and deployment of very large diameter valves from the inferior or superior vena cava to the tricuspid valve or trans-atrial delivery and deployment to the mitral valve, the valves having a height of about 5-60 mm and a diameter of about 25-80 mm, without extra-large diameter catheters and without delivery and deployment from catheters at acute access angles.