254 results about "Valve prosthesis" patented technology

A heart valve prosthesis for replacing a diseased native valve in a patient. The valve prosthesis includes a compressible and expandable frame structure and an anchor connected to an outer periphery of the frame structure. The anchor comprises a helical wire having a free end. The valve may further include a valve segment mounted within the frame structure and expanded with the frame structure. The frame structure may be configured for receiving a valve segment.

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

A transcatheter heart valve prosthesis is disclosed that includes a tubular frame, which defines a central lumen of the prosthesis, and a tubular valve-skirt subassembly disposed within the central lumen. The valve-skirt subassembly includes a skirt element and a valve component having a plurality of leaflets. Each leaflet of the plurality of leaflets is formed to have a first commissure tab and a second commissure tab disposed at opposing lateral ends of the leaflet. The first commissure tab of a respective leaflet, in a folded state, forms a first commissure of the respective leaflet that is directly coupled only to the skirt element of the valve-skirt subassembly, and the second commissure tab of the respective leaflet, in a folded state, forms a second commissure of the respective leaflet that is directly coupled only to the skirt element of the valve-skirt subassembly.

Devices and methods for delivering one or more portions of a valve prosthesis into the heart of a patient. The device may include one or more catheters operably coupled to one or more controls for controlling axial movement, rotational movement, and / or deflection of the one or more catheters during delivery of the valve prosthesis to the heart. The one or more controls may provide coarse and fine motion control of multiple degrees of freedom of the one or more catheters, thereby providing better control to physicians during valve prosthesis delivery procedures.

A heart valve prosthesis is positioned within an index valve prosthesis. The heart valve prosthesis includes an annular frame extending along a valve axis between a first valve end and a second valve end. The annular frame includes a plurality of frame members and is adjustable between a radially-collapsed configuration and a radially- expanded configuration. The annular frame includes a central region including a folded segment that moves between a first configuration and a second configuration. The folded segment is biased toward the second configuration. The folded segment defines a channel on an outer radial side of the folded segment when the folded segment is in the second configuration. The channel receives at least one lacerated leaflet of the index valve prosthesis. Methods of implanting a heart valve prosthesis are provided.

A heart valve prosthesis comprising a radially expandable and compressible annular frame is disclosed. The frame comprises a plurality of interconnected rows of cells disposed between an inflow end and an outflow end of the frame, the interconnected rows of cells comprising a plurality of outflow struts defining the outflow end and a plurality of inflow struts defining the inflow end. The frame further comprises a plurality of tip regions formed at the inflow end and the outflow end, each tip region curved between two angled strut portions and forming one of the outflow struts or one of the inflow struts with the two angled strut portions.Each tip region has a reduced width and a length extending at least 25% of the total length of the outflow strut or the inflow strut, the reduced width being less than the width of the two angled strut sections.

The invention discloses a valve prosthesis which comprises an inflow end and an outflow end, the valve prosthesis comprises a support, a sealing piece and a covering film, the covering film at least covers the part, close to the inflow end, of the support, the sealing piece comprises a sealing material, a first fixing piece and a second fixing piece, and the sealing material comprises a first edge and a second edge which are oppositely arranged; the first edge or an area near the first edge is fixed with the covering film through the first fixing piece, then the second edge is close to the first edge in a rolling or folding mode to form an annular structure arranged on the outer side of the covering film, and then the annular structure and the covering film are fixed through the second fixing piece, so that the sealing piece which is accurately positioned and shaped on the valve prosthesis support can be obtained. Therefore, the perivalvular leakage prevention device can better adapt to the in-vivo physiological environment, and the perivalvular leakage situation is greatly reduced.

The invention relates to an intracavity implantation system which comprises an intracavity prosthesis, the intracavity prosthesis has a radial expansion state and a radial contraction state, the intracavity prosthesis comprises a covered stent, a valve prosthesis and a flexible connecting pipe, the covered stent is of a tubular structure and comprises a main body section and a reducing section which are communicated with each other, and the valve prosthesis is arranged in the main body section. The main body section and the reducing section are arranged in the axial direction of the covered stent, the cross section area of the near end of the reducing section is smaller than that of the far end of the reducing section, the covered stent is further provided with a window penetrating through the side wall of the covered stent, and at least part of the area of the window is located in the reducing section; the valve prosthesis comprises a valve support and an artificial valve leaflet connected to the interior of the valve support. The flexible connecting pipe is of a tubular structure defined by a flexible film, the far end of the flexible connecting pipe is connected with the reducing section, the near end of the flexible connecting pipe is connected with the valve prosthesis, and the two axial ends of the flexible connecting pipe are communicated with the covered stent and the valve prosthesis respectively. In the implanting process of the endoluminal prosthesis, the relative position of the valve prosthesis and the covered stent can be adjusted according to the lumen structure, and the endoluminal prosthesis can better adapt to various lumen structures. In addition, due to the arrangement of the flexible connecting pipe, the risk that the far end of the valve prosthesis is driven to expand and deform due to expansion of the covered stent can be reduced, force generated in the expansion process of the valve prosthesis is not prone to being transmitted to the covered stent, and therefore the risk that coronary blood flow is blocked due to expansion of the near end of the covered stent can be reduced.

A transcatheter valve prosthesis including a tubular stent, a prosthetic valve component disposed within and secured to the stent, and a centering mechanism coupled to and encircling an outer surface of the tubular stent. The centering mechanism includes a self-expanding centering ring having an expanded diameter in the expanded configuration that is greater than an expanded diameter of the tubular stent in the expanded configuration and a plurality of self-expanding spokes radially extending between the tubular stent and the centering ring. The centering mechanism may include a base ring and / or a skirt. Alternatively, the centering mechanism includes a plurality of self-expanding loops. When each loop is in a delivery configuration the loop has a straightened profile that proximally extends from a proximal end of the tubular stent. When each loop is in an expanded configuration the loop has a U-shaped profile radially spaced apart from the tubular stent.

A side-deliverable prosthetic heart valve includes an outer frame and a flow control component. The outer frame defines a central channel that extends along a central axis. The flow control component is disposed within the central channel and coupled to the outer frame. The flow control component has a set of leaflets mounted within an inner frame. The prosthetic valve is configured to be folded along a longitudinal axis and compressed along the central axis to place the prosthetic valve in a compressed configuration for delivery via a delivery catheter. The longitudinal axis is substantially parallel to a lengthwise axis of the delivery catheter when disposed therein. The prosthetic valve transitions to an expanded configuration when released from the delivery catheter. The flow control component elastically deforms from a substantially cylindrical configuration to a substantially flattened configuration when the prosthetic valve is placed in the compressed configuration.

A valve prosthesis includes a self-expanding frame and a prosthetic valve coupled to an interior of the frame. The frame includes a plurality of endcrowns at a first end thereof, and a first paddle connected to a first endcrown by a first stem. The first end of the frame is collapsible to a collapsed configuration when a restraining force is applied to the first paddle and to the endcrowns, is configured to expand from the collapsed configuration to a partially deployed configuration when the restraining force is removed from the endcrowns but is still applied to the first paddle, and is configured to expand to a fully deployed configuration when the restraining force is removed from the endcrowns and from the first paddle. A first vale of a lateral dimension of the first end in the partially deployed configuration is at least 70 percent of a second value of the lateral dimension of the first end in the fully deployed configuration.

The invention provides a conveying assembly and a conveying system. The conveying assembly comprises a bending adjusting wire and a conveying pipe. The conveying pipe comprises a sheath pipe section and an outer pipe section, the sheath pipe section is located at the far end of the outer pipe section, the sheath pipe section wraps at least one part of the outer pipe section, and the sheath pipe section is used for wrapping the valve prosthesis; the bending adjusting wire is parallel to the axial direction of the conveying pipe and penetrates through the inner wall of the conveying pipe, and the bending adjusting wire is folded back at the far end of the sheath pipe section and used for driving the conveying pipe to be bent in the process of conveying the valve prosthesis. According to the configuration, the bending adjusting wire is arranged on the inner wall of the conveying pipe in a penetrating mode and is bent back at the far end of the sheathing canal section, so that the action point of the bending adjusting wire is located at the far end of the sheathing canal section, meanwhile, the sheathing canal section wraps the valve prosthesis, the axial distance between the action point of the bending adjusting wire and the valve prosthesis is shortened, and the coaxial effect of the valve prosthesis and the native valve ring is effectively guaranteed.

The invention relates to the technical field of medical instruments, and provides a supporting tube and a sheathing canal for an interventional operation, and the supporting tube for the interventional operation comprises a body section and an expandable section located at the far end of the body section; the expandable section comprises a plurality of through holes, the through holes located in the same row in the circumferential direction form a circumferential through hole group, and a plurality of rows of circumferential through hole groups are formed in the expandable section in the axial direction; and the sizes of the through holes in the plurality of rows of circumferential through hole groups are gradually reduced from the far end to the near end. According to the technical scheme, the problem of stress concentration of the sheathing canal in the process of releasing and recovering the valve prosthesis can be solved.

The invention discloses an aorta valved conduit with a coronary artery bridging vessel, comprising: an ascending aorta prosthesis comprising an ascending aorta stent; the valve prosthesis comprises a valve support and a valve blade, the valve support is coated with a valve covering film, and a bridging port used for bridging the coronary artery bridging blood vessel prosthesis or the coronary artery bridging blood vessel prosthesis communicated with the interior of the valve prosthesis is arranged on the valve covering film; the guide stent comprises at least one group of connecting rib units, the connecting rib units are connected with the ascending aorta stent and are arranged along the longitudinal direction of the ascending aorta stent, and one end of each connecting rib unit is connected with the valve stent so as to restrain the bending direction of the ascending aorta stent; the ascending aorta stent can only be bent along the plane where the connecting rib units and the central axis of the ascending aorta stent are located. The covering film is arranged outside the valve prosthesis in a covering mode, it is guaranteed that blood in the valve prosthesis cannot leak, and the coronary artery bridging blood vessel prosthesis is connected to the valve prosthesis so that the interior of the valve pipeline can be communicated with coronary artery blood flow.

The invention discloses an intrusive aorta valved conduit, comprising: an ascending aorta prosthesis comprising an ascending aorta stent, and an ascending aorta covering film covering the ascending aorta stent, so that the ascending aorta prosthesis can be adapted to the inner wall of the ascending aorta and form a sealing fit with the inner wall of the ascending aorta; the valve prosthesis comprises a valve support and a valve blade. Comprising at least one group of connecting rib units, the connecting rib units are connected with the ascending aorta stent and arranged in the longitudinal direction of the ascending aorta stent, and one ends of the connecting rib units are connected with the valve stent to restrain the bending direction of the ascending aorta stent; the ascending aorta stent can only be bent along the plane where the connecting rib units and the central axis of the ascending aorta stent are located. Through the arrangement of the connecting ribs, the angle of the valved pipeline in the input process can be controlled, so that the bending direction of the valved pipeline in the in-vivo conveying process is accurately controlled, the implantation angle of the instrument is convenient to adjust and control, the instrument can be accurately aligned with the boundary edge of a native valve leaflet, and the implantation precision of the valved pipeline is guaranteed.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

The present invention discloses an artificial valve prosthesis, comprising a stent body and a leaflet assembly. The stent body includes a first stent and a second stent. The first stent has a connection end. Wherein, the second stent includes a plurality of stent rods, and the plurality of stent rods are respectively fixed to the connection end of the first stent. The leaflet assembly has a first leaflet fixing portion, and the leaflet assembly is fixed to the connection end of the first stent through the first leaflet fixing portion. Compared with the prior art framework structure composed of a plurality of closed geometric units, the second stent of the present invention is mainly composed of a plurality of stent rods, reducing the material of the stent body of the present invention, thereby reducing the cross-sectional area of the delivery device, and thus reducing the trauma area of the patient; in addition, the stent structure in the area sandwiched between the leaflet assembly and the second stent is relatively sparse, and blood is not easily deposited there, thus reducing the risk of thrombus formation.

The utility model relates to an expandable artificial valve prosthesis which is characterized in that channels are formed in an elastic valve prosthesis, and a Tesla valve structure is arranged in each channel; an instrument guide hole is formed in the elastic valve prosthesis and can be communicated with the inflow end and the outflow end; the end face of the inflow end and the end face of the outflow end are each provided with an elastic sealing body used for closing the instrument guide hole, each elastic sealing body is provided with a disconnection part, and the disconnection parts are in a normally-closed state under the elastic force action of the elastic sealing bodies so as to close the instrument guide holes. A transition layer is circumferentially arranged on the outer wall of the elastic valve prosthesis in a surrounding manner, and the transition layer has plasticity; the valve frames are arranged at the inflow end and the outflow end respectively and connected with the transition layer, or the valve frames are directly and fixedly connected with the elastic valve prosthesis. The expandable artificial valve prosthesis disclosed by the utility model can be expanded, so that the overall diameter size of the expandable artificial valve prosthesis disclosed by the utility model is changed, and the expandable artificial valve prosthesis can be adapted to heart structure tissues with larger sizes.

The invention relates to a valve prosthesis which comprises a stent body and a valve leaflet, the stent body comprises an outflow end and an inflow end, the stent body comprises an inner stent and an outer stent, the inner stent is arranged in the outer stent, the valve leaflet is arranged in the inner stent, and the outflow end comprises a plurality of connecting points. The outer-layer stent and the inner-layer stent are connected with the connecting points after being connected at the outflow end or at the position close to the outflow end, a circle is defined by the multiple connecting points, the circle is provided with a circumference, the circumference is equally divided by the multiple connecting points, on one hand, it can be guaranteed that the outflow end of the stent body is of a symmetrical structure, and the stent body can be evenly compressed into a conveying sheath tube; on the other hand, it can be guaranteed that the stent body is evenly stressed when placed at the lesion position, and therefore the stent body is not prone to falling off.

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

The application provides a heart valve prosthesis and a preparation method thereof, the heart valve prosthesis comprising a stent and an integrated valve, the integrated valve comprising artificial valve leaves and a skirt, and the integrated valve being fixed to the stent by sewing threads; the preparation method comprises the following steps: obtaining an integrated valve material, and sequentially subjecting the integrated valve material to cutting, pre-shaping and folding processes, and finally sewing the folded integrated valve material on the stent to obtain the heart valve prosthesis. The application can minimize the damage to the valve, increase the durability of the valve, simplify the sewing process, reduce the production cost and improve the production efficiency.

A valve prosthesis includes a self-expanding frame and a prosthetic valve coupled to an interior of the frame. The frame includes a plurality of end crowns at a first end thereof, and a first blade connected to the first end crown by a first rod. The first end of the frame is collapsible to a collapsed configuration when a constraining force is applied to the first blade and the end crown, is configured to expand from the collapsed configuration to a partially deployed configuration when the constraining force is removed from the end crown but still applied to the first blade, and is configured to expand to a fully deployed configuration when the constraining force is removed from the end crown and the first blade. A first value of a lateral dimension of the first end in the partially deployed configuration is at least 70% of a second value of a lateral dimension of the first end in the fully deployed configuration.

A capsule of a delivery system for a transcatheter heart valve prosthesis includes markers for rotationally orienting the capsule within a native valve. The capsule includes markers that are sized and located on the capsule such that when viewed in a cusp overlap viewing angle image, the markers indicate whether the capsule is in a desired rotational orientation. Methods for rotationally aligning a capsule of a delivery system containing a transcatheter heart valve prosthesis within a native valve are also provided.

The invention provides a valve prosthesis which comprises a support, a valve leaflet and a skirt, the valve prosthesis comprises an inflow end and an outflow end, the support has a compressed state and an expanded state, the valve leaflet comprises at least two valve leaflet structures, each valve leaflet structure comprises a valve angle, and the adjacent valve leaflet structures are connected through the valve angles.

The invention provides a delivery system. The delivery system comprises a sheath tube, a sheath core and a sheath core connector, the sheath core is nested in an inner cavity of the sheath tube, and the sheath core comprises a sheath core main body tube and two reference wires which are symmetrical about the center of the sheath core; the sheath core connector is arranged on the sheath core in a sleeving mode and comprises a fixing part at the near end and a rotating part at the far end, the fixing part is fixedly arranged on the sheath core body tube, and the rotating part can rotate relative to the sheath core. According to the conveying system, before the valve prosthesis is loaded into the sheathing canal, the sheath core connector rotating part can be rotated to circumferentially adjust the valve prosthesis to the optimal position, it is ensured that after the valve prosthesis is conveyed to the designated position, the connection part of the valve prosthesis is aligned with connection of a native aortic valve, and the release accuracy is improved.

The present invention relates to heart surgical instruments, in particular to a valve prosthesis device having a segmented tapered structure. The device comprises an outer stent and an inner stent. The outer stent comprises a disc-shaped structure deployed on the atrial side, an annular structure matched with the valve annulus side, and split structures having different tapers and deployed on the ventricular side. Resilient clamping members are distributed on the peripheral side of the outer stent on the basis of original valve leaflets. The inner stent is connected to the interior of the outer stent, and is internally provided with a valve body. The device further comprises barbs or protrusions selectively or integrally distributed on the annular structure of the outer stent, which are used for anchoring a valve prosthesis to the congenital valve annulus of the heart. The disc-shaped structure and the annular structure are of a round structure or a special-shaped structure; and the split structures having different tapers are distributed at 60°-120°. Using the split tapered structure can reduce obstructions of outflow tracts and improve the adaptability of prostheses.

The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall. In the third state, the second clamping member protrudes from the first clamping member and extends in a circumferential direction of the frame body and abuts against an outer surface of the frame body, so that an autologous valve leaflet and adjacent tissues are capable of being clamped between the second clamping member, the first clamping member, and the frame body. The contact area between the valve prosthesis and the autologous tissues can be increased, the position stability of the valve prosthesis in the heart can be improved, and the success rate of the operation can be increased.

This invention discloses a valve prosthesis, including an inflow end and an outflow end. The valve prosthesis includes a support, a seal, and a cover. The cover at least covers the portion of the support near the inflow end. The seal includes a sealing material, a first fixing member, and a second fixing member. The sealing material includes a first side and a second side disposed opposite to each other. The first side or its vicinity is fixed to the cover with the first fixing member. Then, the second side is rolled or folded to approach the first side, forming an annular structure disposed on the outside of the cover. The second fixing member then fixes the annular structure to the cover. This invention provides a seal that is precisely positioned and shaped on the valve prosthesis support, thereby better adapting to the physiological environment in the body and greatly reducing the occurrence of paravalvular leakage.