212 results about "Valve prosthesis" patented technology

The disclosure relates to heart have prostheses with the reduced need of pacemaker implantation and improved means for positioning the replacement heart valve. In one aspect of the present disclosure, the stent scaffold of the valve prosthesis includes axially extending locators. The locators may be positioned within the cusp of the native aortic valve. Placement of the locators within the cusps may prevent further proximal movement of the stent scaffold into the left ventricle. By adjusting the location of the proximal end of the locators with respect to the proximal end of the stent scaffold, infra-annular placement of the stent scaffold in the aortic annulus may be assured. In another aspect, means for visualizing the positioning of replacement heart valves at an implant site inside an individual's body is disclosed.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

A heart valve prosthesis is positioned within an index valve prosthesis. The heart valve prosthesis includes an annular frame extending along a valve axis between a first valve end and a second valve end. The annular frame includes a plurality of frame members and is adjustable between a radially-collapsed configuration and a radially- expanded configuration. The annular frame includes a central region including a folded segment that moves between a first configuration and a second configuration. The folded segment is biased toward the second configuration. The folded segment defines a channel on an outer radial side of the folded segment when the folded segment is in the second configuration. The channel receives at least one lacerated leaflet of the index valve prosthesis. Methods of implanting a heart valve prosthesis are provided.

A heart valve prosthesis comprising a radially expandable and compressible annular frame is disclosed. The frame comprises a plurality of interconnected rows of cells disposed between an inflow end and an outflow end of the frame, the interconnected rows of cells comprising a plurality of outflow struts defining the outflow end and a plurality of inflow struts defining the inflow end. The frame further comprises a plurality of tip regions formed at the inflow end and the outflow end, each tip region curved between two angled strut portions and forming one of the outflow struts or one of the inflow struts with the two angled strut portions.Each tip region has a reduced width and a length extending at least 25% of the total length of the outflow strut or the inflow strut, the reduced width being less than the width of the two angled strut sections.

The invention discloses a valve prosthesis which comprises an inflow end and an outflow end, the valve prosthesis comprises a support, a sealing piece and a covering film, the covering film at least covers the part, close to the inflow end, of the support, the sealing piece comprises a sealing material, a first fixing piece and a second fixing piece, and the sealing material comprises a first edge and a second edge which are oppositely arranged; the first edge or an area near the first edge is fixed with the covering film through the first fixing piece, then the second edge is close to the first edge in a rolling or folding mode to form an annular structure arranged on the outer side of the covering film, and then the annular structure and the covering film are fixed through the second fixing piece, so that the sealing piece which is accurately positioned and shaped on the valve prosthesis support can be obtained. Therefore, the perivalvular leakage prevention device can better adapt to the in-vivo physiological environment, and the perivalvular leakage situation is greatly reduced.

The invention relates to an intracavity implantation system which comprises an intracavity prosthesis, the intracavity prosthesis has a radial expansion state and a radial contraction state, the intracavity prosthesis comprises a covered stent, a valve prosthesis and a flexible connecting pipe, the covered stent is of a tubular structure and comprises a main body section and a reducing section which are communicated with each other, and the valve prosthesis is arranged in the main body section. The main body section and the reducing section are arranged in the axial direction of the covered stent, the cross section area of the near end of the reducing section is smaller than that of the far end of the reducing section, the covered stent is further provided with a window penetrating through the side wall of the covered stent, and at least part of the area of the window is located in the reducing section; the valve prosthesis comprises a valve support and an artificial valve leaflet connected to the interior of the valve support. The flexible connecting pipe is of a tubular structure defined by a flexible film, the far end of the flexible connecting pipe is connected with the reducing section, the near end of the flexible connecting pipe is connected with the valve prosthesis, and the two axial ends of the flexible connecting pipe are communicated with the covered stent and the valve prosthesis respectively. In the implanting process of the endoluminal prosthesis, the relative position of the valve prosthesis and the covered stent can be adjusted according to the lumen structure, and the endoluminal prosthesis can better adapt to various lumen structures. In addition, due to the arrangement of the flexible connecting pipe, the risk that the far end of the valve prosthesis is driven to expand and deform due to expansion of the covered stent can be reduced, force generated in the expansion process of the valve prosthesis is not prone to being transmitted to the covered stent, and therefore the risk that coronary blood flow is blocked due to expansion of the near end of the covered stent can be reduced.

A transcatheter valve prosthesis including a tubular stent, a prosthetic valve component disposed within and secured to the stent, and a centering mechanism coupled to and encircling an outer surface of the tubular stent. The centering mechanism includes a self-expanding centering ring having an expanded diameter in the expanded configuration that is greater than an expanded diameter of the tubular stent in the expanded configuration and a plurality of self-expanding spokes radially extending between the tubular stent and the centering ring. The centering mechanism may include a base ring and / or a skirt. Alternatively, the centering mechanism includes a plurality of self-expanding loops. When each loop is in a delivery configuration the loop has a straightened profile that proximally extends from a proximal end of the tubular stent. When each loop is in an expanded configuration the loop has a U-shaped profile radially spaced apart from the tubular stent.

A valve prosthesis includes a self-expanding frame and a prosthetic valve coupled to an interior of the frame. The frame includes a plurality of endcrowns at a first end thereof, and a first paddle connected to a first endcrown by a first stem. The first end of the frame is collapsible to a collapsed configuration when a restraining force is applied to the first paddle and to the endcrowns, is configured to expand from the collapsed configuration to a partially deployed configuration when the restraining force is removed from the endcrowns but is still applied to the first paddle, and is configured to expand to a fully deployed configuration when the restraining force is removed from the endcrowns and from the first paddle. A first vale of a lateral dimension of the first end in the partially deployed configuration is at least 70 percent of a second value of the lateral dimension of the first end in the fully deployed configuration.

The invention relates to the technical field of medical instruments, and provides a supporting tube and a sheathing canal for an interventional operation, and the supporting tube for the interventional operation comprises a body section and an expandable section located at the far end of the body section; the expandable section comprises a plurality of through holes, the through holes located in the same row in the circumferential direction form a circumferential through hole group, and a plurality of rows of circumferential through hole groups are formed in the expandable section in the axial direction; and the sizes of the through holes in the plurality of rows of circumferential through hole groups are gradually reduced from the far end to the near end. According to the technical scheme, the problem of stress concentration of the sheathing canal in the process of releasing and recovering the valve prosthesis can be solved.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

The present invention discloses an artificial valve prosthesis, comprising a stent body and a leaflet assembly. The stent body includes a first stent and a second stent. The first stent has a connection end. Wherein, the second stent includes a plurality of stent rods, and the plurality of stent rods are respectively fixed to the connection end of the first stent. The leaflet assembly has a first leaflet fixing portion, and the leaflet assembly is fixed to the connection end of the first stent through the first leaflet fixing portion. Compared with the prior art framework structure composed of a plurality of closed geometric units, the second stent of the present invention is mainly composed of a plurality of stent rods, reducing the material of the stent body of the present invention, thereby reducing the cross-sectional area of the delivery device, and thus reducing the trauma area of the patient; in addition, the stent structure in the area sandwiched between the leaflet assembly and the second stent is relatively sparse, and blood is not easily deposited there, thus reducing the risk of thrombus formation.

The utility model relates to an expandable artificial valve prosthesis which is characterized in that channels are formed in an elastic valve prosthesis, and a Tesla valve structure is arranged in each channel; an instrument guide hole is formed in the elastic valve prosthesis and can be communicated with the inflow end and the outflow end; the end face of the inflow end and the end face of the outflow end are each provided with an elastic sealing body used for closing the instrument guide hole, each elastic sealing body is provided with a disconnection part, and the disconnection parts are in a normally-closed state under the elastic force action of the elastic sealing bodies so as to close the instrument guide holes. A transition layer is circumferentially arranged on the outer wall of the elastic valve prosthesis in a surrounding manner, and the transition layer has plasticity; the valve frames are arranged at the inflow end and the outflow end respectively and connected with the transition layer, or the valve frames are directly and fixedly connected with the elastic valve prosthesis. The expandable artificial valve prosthesis disclosed by the utility model can be expanded, so that the overall diameter size of the expandable artificial valve prosthesis disclosed by the utility model is changed, and the expandable artificial valve prosthesis can be adapted to heart structure tissues with larger sizes.

The invention relates to a valve prosthesis which comprises a stent body and a valve leaflet, the stent body comprises an outflow end and an inflow end, the stent body comprises an inner stent and an outer stent, the inner stent is arranged in the outer stent, the valve leaflet is arranged in the inner stent, and the outflow end comprises a plurality of connecting points. The outer-layer stent and the inner-layer stent are connected with the connecting points after being connected at the outflow end or at the position close to the outflow end, a circle is defined by the multiple connecting points, the circle is provided with a circumference, the circumference is equally divided by the multiple connecting points, on one hand, it can be guaranteed that the outflow end of the stent body is of a symmetrical structure, and the stent body can be evenly compressed into a conveying sheath tube; on the other hand, it can be guaranteed that the stent body is evenly stressed when placed at the lesion position, and therefore the stent body is not prone to falling off.

The invention relates to the technical field of medical instruments, and provides a valve prosthesis and a preparation method thereof.The valve prosthesis comprises a valve frame and a flexible leakage-proof part arranged on the valve frame; the direction, where blood can flow, of the valve prosthesis is defined as the vertical direction, the valve frame comprises a positioning part which can be positioned on the upper side of a human heart valve ring, and the flexible leakage-proof piece comprises a containing part which can be filled with blood and is located on the lower side of the positioning part after being filled with the blood. The containing part comprises an inward extending section extending inwards in the radial direction of the valve frame and an edge part located on the edge of the inward extending section, at least part of the edge part extends outwards in the radial direction of the valve frame to form an outward extending section, and the outward extending section is located on the upper side of the inward extending section. According to the technical scheme, the problem of perivalvular leakage is solved.

The application provides a heart valve prosthesis and a preparation method thereof, the heart valve prosthesis comprising a stent and an integrated valve, the integrated valve comprising artificial valve leaves and a skirt, and the integrated valve being fixed to the stent by sewing threads; the preparation method comprises the following steps: obtaining an integrated valve material, and sequentially subjecting the integrated valve material to cutting, pre-shaping and folding processes, and finally sewing the folded integrated valve material on the stent to obtain the heart valve prosthesis. The application can minimize the damage to the valve, increase the durability of the valve, simplify the sewing process, reduce the production cost and improve the production efficiency.

A capsule of a delivery system for a transcatheter heart valve prosthesis includes markers for rotationally orienting the capsule within a native valve. The capsule includes markers that are sized and located on the capsule such that when viewed in a cusp overlap viewing angle image, the markers indicate whether the capsule is in a desired rotational orientation. Methods for rotationally aligning a capsule of a delivery system containing a transcatheter heart valve prosthesis within a native valve are also provided.

The invention provides a valve prosthesis which comprises a support, a valve leaflet and a skirt, the valve prosthesis comprises an inflow end and an outflow end, the support has a compressed state and an expanded state, the valve leaflet comprises at least two valve leaflet structures, each valve leaflet structure comprises a valve angle, and the adjacent valve leaflet structures are connected through the valve angles.

The invention provides a delivery system. The delivery system comprises a sheath tube, a sheath core and a sheath core connector, the sheath core is nested in an inner cavity of the sheath tube, and the sheath core comprises a sheath core main body tube and two reference wires which are symmetrical about the center of the sheath core; the sheath core connector is arranged on the sheath core in a sleeving mode and comprises a fixing part at the near end and a rotating part at the far end, the fixing part is fixedly arranged on the sheath core body tube, and the rotating part can rotate relative to the sheath core. According to the conveying system, before the valve prosthesis is loaded into the sheathing canal, the sheath core connector rotating part can be rotated to circumferentially adjust the valve prosthesis to the optimal position, it is ensured that after the valve prosthesis is conveyed to the designated position, the connection part of the valve prosthesis is aligned with connection of a native aortic valve, and the release accuracy is improved.

The present invention relates to heart surgical instruments, in particular to a valve prosthesis device having a segmented tapered structure. The device comprises an outer stent and an inner stent. The outer stent comprises a disc-shaped structure deployed on the atrial side, an annular structure matched with the valve annulus side, and split structures having different tapers and deployed on the ventricular side. Resilient clamping members are distributed on the peripheral side of the outer stent on the basis of original valve leaflets. The inner stent is connected to the interior of the outer stent, and is internally provided with a valve body. The device further comprises barbs or protrusions selectively or integrally distributed on the annular structure of the outer stent, which are used for anchoring a valve prosthesis to the congenital valve annulus of the heart. The disc-shaped structure and the annular structure are of a round structure or a special-shaped structure; and the split structures having different tapers are distributed at 60°-120°. Using the split tapered structure can reduce obstructions of outflow tracts and improve the adaptability of prostheses.

The present application relates to a stepwise-clamping type valve prosthesis including a frame body and a clamping member. The frame body has a channel allowing blood to flow therethrough. The clamping member includes a first clamping member and a second clamping member. One end of the first clamping member is connected to the frame body, and the other end of the first clamping member is a free end. The second clamping member is connected to the first clamping member. The clamping member has three states in sequence from being restricted to being fully released. In the first state, the first clamping member and the second clamping member are both restricted. In the second state, the second clamping member is restricted, and the first clamping member extends in a radial direction of the frame body and is capable of reaching a position between a valve leaflet and a heart wall. In the third state, the second clamping member protrudes from the first clamping member and extends in a circumferential direction of the frame body and abuts against an outer surface of the frame body, so that an autologous valve leaflet and adjacent tissues are capable of being clamped between the second clamping member, the first clamping member, and the frame body. The contact area between the valve prosthesis and the autologous tissues can be increased, the position stability of the valve prosthesis in the heart can be improved, and the success rate of the operation can be increased.

This invention discloses a valve prosthesis, including an inflow end and an outflow end. The valve prosthesis includes a support, a seal, and a cover. The cover at least covers the portion of the support near the inflow end. The seal includes a sealing material, a first fixing member, and a second fixing member. The sealing material includes a first side and a second side disposed opposite to each other. The first side or its vicinity is fixed to the cover with the first fixing member. Then, the second side is rolled or folded to approach the first side, forming an annular structure disposed on the outside of the cover. The second fixing member then fixes the annular structure to the cover. This invention provides a seal that is precisely positioned and shaped on the valve prosthesis support, thereby better adapting to the physiological environment in the body and greatly reducing the occurrence of paravalvular leakage.

The present invention relates to an atrioventricular heart valve prosthesis implantable, for example, into the heart of a mammal. The heart valve prosthesis comprises a collapsible-expandable tubular stent having a lumen, preferably having an opening cross-section or area during use or in a fully expanded state of the stent that is smaller than an opening area of a native atrioventricular heart valve to be replaced by the heart valve prosthesis. The heart valve prosthesis further includes an inner valve tip disposed within the lumen of the tubular stent that closes the heart valve by resting against each other, an outer valve leaflet that closes against the native valve leaflet, and at least one anchor wire connected directly or indirectly to the tubular stent. The invention also relates to a method for manufacturing a heart valve prosthesis and to a method for inserting a heart valve prosthesis.

This invention relates to a valve prosthesis and a stent, the stent comprising a first stent. The first stent includes two first rod groups, and a first axial rod and a second axial rod connecting the two first rod groups and arranged along the axial direction of the stent. Each first rod group includes a plurality of first rods connected end-to-end and arranged in a W-shape. The first crests of the two first rod groups are arranged opposite each other, and the first troughs are arranged opposite each other. At least one or more of the two oppositely arranged first crests are connected by one or more first axial rods, and the two oppositely arranged first troughs are connected by one or more second axial rods. In this way, the arrangement density of the axial rods can be increased, thereby improving the radial support strength, so that it can be stably fixed at the location of the original valve; in addition, the enclosed quadrilateral structure can be easily bent under stress, that is, it will not affect the normal storage and folding of the stent.

The present embodiments relate to systems and methods for treating luminal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of luminal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.

This invention provides a valve prosthesis, comprising: a valve stent, leaflets, and a leaflet connector; the valve stent has a support rod; the leaflet connector includes a folded portion and a connecting portion, the folded portion being used to fold and accommodate the support rod; the connecting portion extends from both ends of the folded portion, and the connecting portion connects to the leaflet, such that the leaflet is connected to the support rod through the leaflet connector. This design improves the leaflet closure and the connection stability between the leaflet and the valve stent, thereby enhancing the overall stability of the valve prosthesis under complex operating conditions.

The application relates to the technical field of medical devices, and discloses a leaflet structure, a preparation method of the leaflet structure and a valve prosthesis. The leaflet structure comprises a leaflet body, the leaflet body comprises a fixed end, a free end and a side wall, the side wall extends from the fixed end to the free end, and the hydrophobicity of the side wall in the region close to the fixed end is greater than the hydrophobicity of the side wall in the region close to the free end. According to the leaflet structure, the hydrophobicity of the side wall close to the fixed end is designed to be greater than the hydrophobicity close to the free end, so that a humidity gradient effect is formed on the side wall, the leaflet body has the function of guiding fluid (i.e. blood) from one side close to the fixed end to one side close to the free end, the probability of blood deposition in the semi-closed region of the leaflet is reduced, and the service life of the leaflet structure is prolonged.

Disclosed is an improved stent and a related replacement heart valve prosthesis exhibiting various features for improved fixation and crush resistance. The stent is characterized by an inner stent fixed to an outer stent with connecting struts. The stent and heart valve prosthesis can be used for replacement of a defective endogenous heart valve.

The invention relates to the field of medical instruments, in particular to a valve prosthesis for replacing a mitral valve, which comprises an outer stent and an inner stent, the outer stent is provided with a fabric layer, the inner stent is provided with an artificial valve leaflet, the outer stent comprises an anchoring section and a self-adaptive section, the anchoring section comprises a grid-type stent and an anchoring assembly, the anchoring assembly comprises a cannula part, a puncture part and a control wire, and the self-adaptive section is provided with a control wire. Barbs and a connecting hole are arranged on the puncture part, the puncture part is arranged in the sleeve part, the puncture part is fixedly connected with the sleeve part, an opening is formed in the sleeve part, and when the control wire penetrates through the connecting hole and is clamped with the other end of the sleeve part in a matched mode to achieve detachable connection, the barbs are limited in the sleeve part; when the control wire is pulled out of the connecting hole, the barbs extend out of the opening and penetrate through the fabric layer to be pricked into the heart tissue; release of the barbs on the puncture part is controllable, an operator can release the stent firstly and then adjust the stent to an ideal position, and then the barbs are further released to anchor the stent.

A dry valve crimping and loading system includes packaging, a crimper disposed in the packaging, and a dry valve prosthesis disposed within a crimper chamber of the crimper. The crimper chamber has a first volume in an expanded state a second volume in a collapsed state, wherein the first volume is greater than the second volume. The crimper is configured to transition the dry valve prosthesis from an uncompressed state to a compressed state when the crimper chamber transitions from the expanded state to the collapsed state to expel the glycerol from the dry valve prosthesis as the crimper transitions the dry valve prosthesis from the uncompressed state to the compressed state.