Disclosed herein are technologies for addressing elevated left-sided filling pressures to mitigate the effects of diastolic dysfunction. Embodiments provide ways to decrease the temporal increase in
blood flow and pressure into the heart from the venous
system. Under
exertion, there is a shift of blood from the 'unstressed' reservoir of vasculature, which primarily comprises the splanchnic
system, to the 'stressed' reservoir, which comprises the heart and lungs. By inhibiting this acute shifting of blood from the 'unstressed' reservoir to the 'stressed' reservoir, an undesirable influx of
blood volume to the already overloaded left heart can be avoided. Certain embodiments provide ways to increase atrial elasticity, or atrial compliance. This enhancement of atrial compliance enables the atrium to 'absorb' the energy of short bursts of high
left atrial pressure. Consequences are a reduction in the
retrograde flow in the pulmonary veins to inhibit acute pulmonary congestion.