The application provides application of a
carbazole derivative Y16 in preparation of a
drug for treating cardiovascular diseases, and belongs to the technical field of medicines.The vasodilatation activity of Y16 is determined by using a rat isolated
thoracic aorta tension measurement, and the change of the vasodilatation effect of Y16 under the intervention of various channel inhibitors is observed, and the influence of Y16 on
blood pressure is determined by using a rat
femoral artery cannulation experiment.The results show that the
carbazole derivative Y16 has a good
dose-dependent vasodilatation effect, and Y16 also shows a
blood pressure lowering effect, so that the
carbazole derivative Y16 can effectively treat cardiovascular diseases is disclosed for the first time, the application provides a theoretical basis for obtaining a candidate compound of a
drug for treating cardiovascular diseases, and also provides a new selection for a
drug for treating cardiovascular diseases in clinic.