26 results about "Coronary flow" patented technology

An aorta intervention catheter device for heart failure comprises a catheter and a bag body arranged at one end of the catheter, an elastic diaphragm is arranged in the bag body, an inner cavity of the bag body is divided into a blood chamber and an air chamber by the elastic diaphragm, the blood chamber is communicated with the catheter, an exhaust assembly is arranged on the bag body, and the air chamber is connected with an air source connector arranged on the bag body; the other end of the catheter is a proximal end, first guide films which are staggered at intervals and inclined towards one side of the proximal end and second guide films which are inclined towards a distal end are arranged on the inner wall of the catheter, and first guide holes and second guide holes which correspond to the first guide films and the second guide films and are communicated with an inner cavity of the catheter are respectively formed in the outer wall of the catheter; the proximal side of the second guide film is provided with at least one set of third guide films which are fixed to the inner wall of the catheter, incline towards the distal end and are tightly attached to each other to be closed. The aorta is directly intervened to enter the heart, and coronary artery blood perfusion is increased in the diastolic period; the left ventricular post-load is reduced in the systolic period, and the heart failure can be more directly treated.

The invention discloses a liver transplantation perioperative concurrent myocardial ischemia risk assessment method and system, and the method comprises the steps: obtaining coronary artery image data of a liver transplantation patient, carrying out the three-dimensional reconstruction according to the coronary artery image data, and generating a personalized coronary artery geometric model; based on the geometric model of the coronary artery, performing numerical simulation on the flowing condition of blood flow in the coronary artery by utilizing a computational fluid mechanics method, obtaining the speed and pressure distribution of the blood flow of the coronary artery through the numerical simulation, and calculating the pressure ratio before and after the coronary artery stenosis; evaluating the coronary ischemia condition according to the pressure ratio, and generating a fractional flow reserve value and a myocardial ischemia risk evaluation report. The coronary artery blood flow reserve score value is calculated by simulating the coronary artery blood flow conditions under different physiological conditions, so that the myocardial ischemia risk possibly faced by a patient during an operation is comprehensively evaluated, and intra-operation decision support is provided for clinicians.

The invention discloses an aorta valved conduit with a coronary artery bridging vessel, comprising: an ascending aorta prosthesis comprising an ascending aorta stent; the valve prosthesis comprises a valve support and a valve blade, the valve support is coated with a valve covering film, and a bridging port used for bridging the coronary artery bridging blood vessel prosthesis or the coronary artery bridging blood vessel prosthesis communicated with the interior of the valve prosthesis is arranged on the valve covering film; the guide stent comprises at least one group of connecting rib units, the connecting rib units are connected with the ascending aorta stent and are arranged along the longitudinal direction of the ascending aorta stent, and one end of each connecting rib unit is connected with the valve stent so as to restrain the bending direction of the ascending aorta stent; the ascending aorta stent can only be bent along the plane where the connecting rib units and the central axis of the ascending aorta stent are located. The covering film is arranged outside the valve prosthesis in a covering mode, it is guaranteed that blood in the valve prosthesis cannot leak, and the coronary artery bridging blood vessel prosthesis is connected to the valve prosthesis so that the interior of the valve pipeline can be communicated with coronary artery blood flow.

The invention discloses an induction type high-precision urine flow or coronary flow measuring device, which belongs to the technical field of medical instruments, and comprises a measuring box, a cantilever beam extending to the outer side of the measuring box is fixed on the inner side of the measuring box through a fixing assembly, and micro-weight sensing elements attached to the upper side and the lower side of the cantilever beam are arranged in the measuring box. The micro-weight sensing element and the variable resistor form a measuring bridge circuit and are connected with an electric signal recording device located on the outer side of the measuring box through a signal line. A liquid collecting assembly is arranged at the outer end part of the cantilever beam, a flow guide pipe fixing rod is arranged on one side of the liquid collecting assembly and is used for vertically fixing an external flow guide pipe, and the inner side of the flow guide pipe fixing rod is fixed on the side wall of the measuring box. The induction type high-precision urine flow or coronary flow measuring device is simple in structure and convenient to use, changes of liquid flow at different flow speeds can be accurately displayed, and the accuracy and scientificity of measurement and analysis of experimental results are effectively improved.

The invention discloses a coronary artery hemodynamic information prediction method, device and equipment, a medium and a product, and relates to the field of biomechanics, and the method comprises the steps: obtaining clinical data, and segmenting the clinical data to obtain a coronary artery three-dimensional model and a heart three-dimensional model; constructing a human body blood circulation system lumped parameter model; determining a personalized human body blood circulation system lumped parameter model of the patient after assignment; constructing a 0-3-dimensional myocardial mechanical coupling model; constructing a first database; obtaining personalized systolic function parameters and diastolic function parameters of the patient based on the first mapping network; constructing a blood vessel 0-3-dimensional coupling model; constructing a second database; obtaining personalized coronary flow field information of the patient based on a second mapping network; the personalized coronary flow field information comprises a pressure field, a velocity field and concentration polarization characteristics of low-density lipoprotein on a blood vessel wall surface. Through network architecture innovation, the bottleneck of the model in the aspects of efficiency and personalization is solved, and the diagnosis precision of the coronary heart disease is improved.

The invention relates to an automatic monitoring method and a monitoring system for coronary artery blood flow, which specifically comprises the following steps of: performing blood vessel segmentation on each frame of image, and extracting a mask, a center line and a diameter; feature points meeting the conditions that the normal distance from the center line is smaller than a threshold value and the local energy entropy meets a preset value are screened in the first-frame blood vessel area for tracking; tracking the points among frames by adopting a pyramid optical flow method, and constructing a non-isotropic weighting matrix solution equation when optical flow displacement is calculated to obtain an initial displacement vector field; an outlier vector in the initial displacement vector field is recognized and corrected, and a corrected velocity field is obtained through weighted average of neighborhood non-outlier vectors; establishing a coupling state space model for the feature points, and solving by taking the corrected velocity field as input to obtain a velocity field considering the blood flow conduction effect; and combining the normal component of the velocity field and the local diameter of the corresponding blood vessel to obtain the coronary artery blood flow.

The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.

The invention belongs to the crossing field of biomedical engineering and computer data processing, particularly relates to the technical field of ultrasonic medical data processing, and discloses a computer implementation method and system for evaluating the coronary artery stenosis degree based on data. Collected echocardiogram data is used as a core analysis object, target coronary blood vessel positioning processing is carried out on color Doppler blood flow imaging data through a computer, and computer-readable multi-dimensional clinical data and a preset coronary flow velocity influence factor database are fused; and performing dynamic optimization of a linear regression equation and subject working characteristic curve analysis by a computer to realize positioning correlation and quantitative calculation of related degree parameters of coronary artery stenosis. Through database dynamic iteration and parameter correction, interference of individual differences on a processing result is effectively avoided, a brand new computer technical scheme is provided for noninvasive accurate analysis of coronary artery disease related data, and the safety and universality of data processing are remarkably improved.

The invention discloses targeted prebiotic plant extraction dietary powder for conditioning hypertension and a preparation method thereof. According to the present invention, the lactobacillus plantarum CECT5716, the bifidobacterium lactis BLa80 and other strains selected in the formula can regulate the renin-angiotensin system balance by inhibiting the activity of the angiotensin converting enzyme so as to reduce the vasosystolic pressure from the neuroendocrine level; hawthorn flavone and pueraria isoflavone directly act on blood vessels to expand peripheral arteries, improve coronary artery blood flow and enhance blood vessel elasticity; the gamma-aminobutyric acid serving as a neurotransmitter can relieve sympathetic nerve hyperexcitation and reduce blood pressure fluctuation caused by emotion or pressure. Meanwhile, prebiotics such as resistant dextrin provide nutrients for probiotics, promote generation of intestinal short-chain fatty acids, activate a vascular endothelium protection pathway through an intestinal-metabolic axis, form a triple antihypertensive network of strain regulation, plant intervention and flora synergy, and cover different pathological links of blood pressure rise.

The invention provides a myocardial coronary artery blood perfusion space-time dynamic evolution imaging system, and relates to the technical field of biomedical imaging, the method comprises the following steps: a connection layer receives a frame data stream containing an original speckle image sent by a user interface layer, and sends the frame data stream to a data processing layer; after the data processing layer receives the frame data stream, the frame data stream is subjected to parallel processing in a video recording unit and a frame analysis unit, and a blood flow index corresponding to each pixel in the original speckle image is obtained; and the connection layer generates a blood flow index distribution diagram based on the received blood flow index corresponding to each pixel in the original speckle image sent by the data processing layer in the first buffer area of the blood flow index diagram conversion unit, and sends the blood flow index distribution diagram to the user interface layer for display. According to the imaging system provided by the invention, the spatial-temporal dynamic evolution process of myocardial coronary blood flow can be observed in real time, the spatial-temporal resolution is very high, and an important index is provided for quality evaluation in coronary artery bypass grafting.

The invention relates to the technical field of medical evaluation. Provided is a coronary artery function evaluation device, comprising: a data acquisition module for synchronously acquiring multi-modal physiological data of a target coronary artery; the data acquisition module comprises a radiography image acquisition unit, a pressure waveform acquisition unit, an electrocardiogram acquisition unit and a blood flow velocity acquisition unit; the data processing module is in communication connection with the data acquisition module, is internally provided with a hemodynamic parameter calculation circuit and is used for performing filtering, fusion and parameter operation on the multi-modal physiological data and outputting an instantaneous blood flow state parameter, an instantaneous blood flow resistance parameter, a blood flow dynamic simulation parameter and a reserve function derivative parameter; and the evaluation module is in communication connection with the data processing module and is used for outputting quantitative evaluation data of the coronary artery function based on a preset hardware evaluation model. According to the device, the coronary artery blood flow and function can be comprehensively and quantitatively evaluated accurately, and the operation complexity and the cost burden are reduced while high accuracy is kept.

This invention discloses a method and system for extracting coronary artery blood flow signals based on anatomical structure segmentation and adaptive filtering. The method includes: simultaneously acquiring B-mode images and Doppler data of the heart and aligning them temporally; using a deep learning model to segment anatomical structures and generate a mask; constructing a clutter shield based on the mask to filter out strong blood flow signals from the cavities; extracting the epicardial boundary to locate candidate coronary artery regions; constructing a spatiotemporal matrix within the candidate regions; using an adaptive truncated singular value decomposition algorithm to separate tissue clutter and obtain coronary blood flow signals; and finally, outputting quantitative indicators after vascular morphology confirmation and angle correction based on the blood flow centerline. This invention effectively solves the problem of extracting weak coronary artery signals under strong interference through physical-level shielding and adaptive filtering, improving the accuracy and robustness of detection.

The present disclosure describes a system that can enable the prediction of coronary flow without invasive medical procedure. The system can generate physical models that can provide an accurate assessment of coronary mechanics and enable realistic simulation of coronary procedures. The models can enable the hemodynamic measurement of flow through the model and the study of flow dynamics through the model and the biomechanics of the model.

The invention provides a traditional Chinese medicine composition for treating heart failure and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components: 1-12 parts of rohdea japonica, 1-12 parts of codonopsis pilosula, 1-12 parts of astragalus membranaceus, 1-12 parts of cassia twig, 1-8 parts of bighead atractylodes rhizome, 1-12 parts of poria cocos, 1-12 parts of radix ophiopogonis, 2-14 parts of semen lepidii, 1-10 parts of radix aconiti lateralis preparata, 1-10 parts of schisandra chinensis, 1-12 parts of hairyvein agrimony, 1-10 parts of pseudo-ginseng, 1-12 parts of epimedium, 1-12 parts of leonurus, 1-10 parts of ligusticum wallichii, 2-14 parts of salvia miltiorrhiza, 2-12 parts of radix sophorae flavescentis and 1-8 parts of liquorice. The traditional Chinese medicine composition can enhance myocardial contractility, increase coronary artery blood flow volume, protect myocardial cells, improve heart functions, obviously improve the heart functions and left ventricular remodeling, discharge liquid retained at the time of heart failure, relieve the pre-load of the heart and relieve edema; load during cardiac contraction is reduced, and excessive work of the heart is avoided.

The invention relates to the technical field of blood flow monitoring, in particular to a coronary artery blood flow monitor which comprises a mounting frame, a blood flow monitor body is movably arranged in the mounting frame, a wire arrangement frame is fixedly connected to the back face of the mounting frame, and a disinfection assembly is arranged on the back of the wire arrangement frame. A monitoring assembly is arranged in the disinfection assembly, a disinfection cover frame is fixedly connected to the back face of the wire arranging frame, and a liquid storage box and a dirty liquid box are fixedly connected to the upper end and the lower end of the disinfection cover frame correspondingly. According to the coronary artery blood flow monitoring device, the coronary artery blood flow monitoring device can be in butt joint with the chest and heart position of a patient in a more adaptive mode, monitoring operation is completed, and in the actual using process, a worker firstly installs the whole blood flow monitoring device body into the installation frame; at the moment, the interface in the blood volume monitor body can be adaptively attached and connected with the contact joint on the front surface of the flat cable rack from the connecting groove of the mounting frame.

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

The present invention provides a method and apparatus for observing high blood flow rates. The method comprises: acquiring multiple frames of laser speckle images of a region to be observed; determining a spatial speckle contrast matrix and a temporal speckle contrast matrix of the region to be observed based on the laser speckle images of the region to be observed; acquiring system coherence parameters, and determining a dynamic scattering component proportional coefficient of the region to be observed based on the system coherence parameters, the spatial speckle contrast matrix, and the temporal speckle contrast matrix; determining a blood flow index matrix of the region to be observed based on the system coherence parameters, the spatial speckle contrast matrix, the temporal speckle contrast matrix, and the dynamic scattering component proportional coefficient; and displaying a blood flow index distribution image of the region to be observed based on the blood flow index matrix. The method and apparatus for observing high blood flow rates provided by the present invention can effectively address the problem of limited measurable range of coronary blood flow rate.

This invention belongs to the field of biomedical technology, specifically relating to a composition for treating ischemic heart disease and its application. This invention combines two or more of ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re, and notoginsenoside R1, which can significantly downregulate the levels of myocardial enzymes, aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) in myocardial coronary effusion, with an inhibitory effect significantly higher than that of a single saponin component and the positive control drug verapamil. Simultaneously, the composition exhibits better recovery capabilities for coronary flow (CF), left ventricular developmental pressure (LVDP), maximum rate of decrease in left ventricular pressure (-dp / dtmax), and heart rate (HR) in myocardial coronary effusion. Therefore, the composition can alleviate and treat myocardial ischemia-reperfusion injury through multiple targets and mechanisms, fundamentally inhibiting the development of ischemic heart disease.

The present application relates to the technical field of medical evaluation. A device for evaluating the function of coronary arteries is provided, comprising: a data acquisition module for synchronously acquiring multi-modal physiological data of a target coronary artery; the data acquisition module comprises a contrast image acquisition unit, a pressure waveform acquisition unit, an electrocardiogram acquisition unit and a blood flow velocity acquisition unit; a data processing module is in communication connection with the data acquisition module, and is internally provided with a hemodynamic parameter calculation circuit for filtering, fusing and parameter operation on the multi-modal physiological data, and outputs instantaneous blood flow state parameters, instantaneous blood flow resistance parameters, blood flow dynamic simulation parameters and reserve function derivative parameters; an evaluation module is in communication connection with the data processing module, and is used for outputting quantitative evaluation data of the function of the coronary artery based on a preset hardware evaluation model. The device can comprehensively and quantitatively and accurately evaluate the blood flow and function of the coronary artery, while maintaining high accuracy, reducing operation complexity and cost burden.

Provided is a coronary blood flow measurement device capable of acquiring significant information for determination of ischemic heart disease caused by stenosis or the like in a coronary blood vessel on the basis of measurement of a blood flow (coronary blood flow) in a blood vessel (coronary blood vessel) of a heart. This coronary blood flow measurement device (10) includes: a CFR acquisition means (12) for acquiring a calculated value of coronary blood flow reserve (CFR); and a cCFR calculation means (14) for obtaining a blood pressure correction CFR (cCFR) by converting the calculated value of the coronary blood flow reserve (CFR) acquired by the CFR acquisition means into a value under a condition of an arbitrary specific value (ΔPs) of an arteriovenous pressure difference (ΔP(a-v)) by using a linear relationship between a maximum hyperemia coronary blood flow (Q(hyp.)) and the arteriovenous pressure difference (ΔP(a-v)).

A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain medical image data related to a coronary artery of a subject. The processing circuitry is configured to derive a value of a blood flow parameter indicating hemodynamics of the coronary artery, on the basis of the medical image data. The processing circuitry is configured to display information indicating a change in the value of the blood flow parameter along the coronary artery, by using a graph of which the vertical axis expresses values of the blood flow parameter and of which the horizontal axis corresponds to the distance direction along the coronary artery and is configured to further display supplementary information indicating the structure of the coronary artery together with the graph.

A medical image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain medical image data related to a coronary artery of a subject. The processing circuitry is configured to derive a value of a blood flow parameter indicating hemodynamics of the coronary artery, on the basis of the medical image data. The processing circuitry is configured to display information indicating a change in the value of the blood flow parameter along the coronary artery, by using a graph of which the vertical axis expresses values of the blood flow parameter and of which the horizontal axis corresponds to the distance direction along the coronary artery and is configured to further display supplementary information indicating the structure of the coronary artery together with the graph.

The present invention relates to the field of ultrasound and imaging of coronary blood flow in the heart. Patients with coronary microvascular dysfunction (CMD) have a poor prognosis and a significantly higher incidence of cardiovascular events, including heart failure, sudden cardiac death, and myocardial infarction (MI) hospitalization. Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available clinically for directly visualizing the coronary microvasculature and assessing the local coronary microvasculature. Blood flow imaging remains a difficult task in the heart due to the rapid motion of this organ. To overcome the limitations of practical imaging methods for coronary blood flow, the inventors have proposed an ultrasound ultrafast imaging method that automatically detects time periods of low myocardial velocity and estimates coronary blood flow velocity and tissue velocity from the same data acquisition.

The present disclosure provides systems and methods for determining an average transit time of blood within a blood vessel using pressure measurements acquired by an intravascular tool and independent of temperature measurements. The intravascular instrument may acquire a plurality of pressure measurements distal to a region of interest within the vessel as the medicament passes through the vessel and is positioned over the instrument. The plurality of pressure measurements may be plotted on a pressure dilution curve. A function of the pressure dilution curve and the time is used to determine an average transport time of the blood within the blood vessel.

The invention discloses an intelligent myocardial ischemia diagnosis system which comprises a coronary blood flow state calculation module, a high-frame-rate cardiac ultrasonic data acquisition module and a coronary lesion judgment module. The coronary artery blood flow state calculation module establishes and trains a machine learning model, and calculates the coronary artery blood flow state by using the machine learning model. The high-frame-rate cardiac ultrasound data acquisition module acquires high-frame-rate cardiac ultrasound data, and the coronary artery lesion judgment module judges whether myocardial ischemia exists or not according to the coronary artery blood flow state calculated by the machine learning model. When the myocardial ischemia exists, judging whether the lesion blood vessel causing the myocardial ischemia is a coronary artery large vessel, a coronary artery microvessel or both of the coronary artery large vessel and the coronary artery microvessel. According to the method, rich coronary blood flow time information of the high-frame-rate cardiac ultrasound data is utilized, and the accuracy of predicting whether myocardial ischemia exists or not and the cause of the myocardial ischemia is high.

A device and a corresponding method for evaluating hemodynamic properties in a coronary vasculature are provided, wherein diagnostic data of a vessel of interest are used to identify first and second measurement locations at which first and second values ​​for a first hemodynamic property can be obtained, whereby these first and second values ​​are suitable for deriving at least one diagnostic parameter indicative of a second hemodynamic property that cannot or should not be directly measured.