142 results about "Coronary flow" patented technology

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

The invention relates to a method and a system for determining the blood flow in an individual coronary artery of a patient, wherein the method comprises the steps of positioning a temperature sensor mounted at a distal portion of a guide wire at a distal position in the coronary artery, positioning an infusion catheter in the coronary artery such that the distal end of the infusion catheter is proximally of the temperature sensor, measuring the blood temperature with the temperature sensor, infusing cold indicator fluid with a known infusion rate and known or measurable temperature into the coronary artery by the infusion catheter, measuring the temperature of the mixture of blood and indicator fluid by the temperature sensor, and calculating the coronary blood flow by a formula based on the known and measured quantities. In an extended version, the method comprises steps for relating the calculated coronary flow value to related normal flow values, or related FFR values, or a related flow resistance.

Diagnostic angiograms only provide the projected lumen of a coronary, which is only an indirect measure of blood flow and pressure decline. According to an exemplary embodiment of the present invention, a motion compensated determination of a flow dynamics and a pressure decline for stenosis grading is provided, in which the motion compensation is performed on the basis of a tracking of a first position of a first marker and a second position of a second marker in the projection data set. This may provide for a robust and precise flow dynamics and pressure decline determination.

The invention relates to a method and a system for determining the blood flow in an individual coronary artery of a patient, wherein the method comprises the steps of positioning a temperature sensor mounted at a distal portion of a guide wire at a distal position in the coronary artery, positioning an infusion catheter in the coronary artery such that the distal end of the infusion catheter is proximally of the temperature sensor, measuring the blood temperature with the temperature sensor, infusing cold indicator fluid with a known infusion rate and known or measurable temperature into the coronary artery by the infusion catheter, measuring the temperature of the mixture of blood and indicator fluid by the temperature sensor, and calculating the coronary blood flow by a formula based on the known and measured quantities. In an extended version, the method comprises steps for relating the calculated coronary flow value to related normal flow values, or related FFR values, or a related flow resistance.

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and / or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.

The invention discloses a method for computing FFR<CT> (fractional flow reserve <computed tomography>) on the basis of personalized coronary artery branch blood flow volumes, and belongs to the field of biomechanics and haemodynamics. The method includes clinically acquiring physiological parameters of cardiac muscle masses, heart rates, blood pressures and the like of patients and establishing coronary blood flow volume computing empirical formulas on the basis of allometric growth laws; rebuilding three-dimensional geometric models of coronary arteries on the basis of CT images of the coronary arteries of the patients, acquiring the volumes of blood vessels of branches of the coronary arteries and the vessel diameters of the various branches and acquiring split ratios of the various branches on the basis of the volumes of the blood vessels of the branches and the Poiseuille law; combining the coronary blood flow volumes of the patients and the split ratios of the various branches with one another, acquiring the blood flow volumes of the various branches of the coronary arteries by means of computing and solving the FFR<CT> of the coronary arteries of the patients by the aid of the blood flow volumes of the various branches of the coronary arteries. The blood flow volumes of the various branches of the coronary arteries are used as coronary haemodynamics computing boundary conditions. The method has the advantages that FFR of the coronary arteries of human bodies can be noninvasively computed, simulation results can be similar to real blood flow states under the condition of the maximum congestion states of the coronary arteries of the patients owing to personalized coronary flow boundaries, and accordingly the coronary artery FFR<CT> computing accuracy can be improved.

A system for evaluating training 1 comprises a pulsating flow generating unit 11 for imparting a pulsating flow to a designated fluid, a coronary artery flow generating unit 12 that branches off from that pulsating flow generating unit 11 and by which a flow condition of that pulsating flow can be converted to generate a coronary artery flow, and a surgery training unit 13 provided between the pulsating flow generating unit 11 and the coronary artery flow generating unit 12 and that operates to enable coronary artery bypass surgery training under pulsation. This system for evaluating training 1 has a circuit configured to enable the coronary artery flow fluid generated by the coronary artery flow generating unit 12 to pass through a simulated blood vessel that has been subjected to a designated treatment in training using the surgery training unit 13.

Embodiments include a system for determining cardiovascular information for a patient with coronary artery disease. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create, for a given level of physical activity, a physics-based model of blood flow through the patient's heart simulated during a selected level of physical activity; determine and normalize one or more values of at least one blood flow characteristic within the patient's heart during the simulated level of physical activity; and compare the one or more normalized values of the at least one blood flow characteristic to a threshold to determine whether the level of physical activity exceeds an acceptable level of risk.

The invention discloses a processing technique of health thorn tea and processing equipment for health thorn tea, which relate to the technical field of processing of agricultural products. The health thorn tea is made of fresh thorn tea leaves. The processing technique includes cutting, primary fixation, primary spreading and cooling, secondary fixation, secondary spreading and cooling, primary rolling, tertiary spreading and cooling, primary baking, secondary rolling, fourth spreading and cooling, secondary baking, grading and packaging. The processed health thorn tea has the advantages of blood glucose lowering, blood lipid lowering, blood pressure lowering, immunity enhancement, heart rate slowing, coronary flow increasing, anticoagulation, antithrombosis, hypoxia tolerance, mononuclear macrophage functional promotion, radio resistance and the like, and is suitable for middle-aged and aged people and people with hyperlipidemia, hypertension and hyperglycemia. The processing technique and the processing equipment for the health thorn tea can also be used for processing common tea and other types of health tea.

A system for evaluating training 1 comprises a pulsating flow generating unit 11 for imparting a pulsating flow to a designated fluid, a coronary artery flow generating unit 12 that branches off from that pulsating flow generating unit 11 and by which a flow condition of that pulsating flow can be converted to generate a coronary artery flow, and a surgery training unit 13 provided between the pulsating flow generating unit 11 and the coronary artery flow generating unit 12 and that operates to enable coronary artery bypass surgery training under pulsation. This system for evaluating training 1 has a circuit configured to enable the coronary artery flow fluid generated by the coronary artery flow generating unit 12 to pass through a simulated blood vessel that has been subjected to a designated treatment in training using the surgery training unit 13.

The invention discloses a gynostemma penta black tea and a preparation method thereof. The gynostemma penta black tea consists of 30%-40% of gynostemma penta leaves and 60%-70% of black tea. The gynostemma penta black tea well combines the nutritive value of the gynostemma penta with the effects of common black tea, has a good anti-stress effect and a ginseng-like adaptogen effect, can enhance specific and non-specific immunization, can promote learning and memory, and has an anti-ageing effect, a blood sugar reduction effect, a blood fat reduction effect, a hepatoprotective effect, a platelet aggregation resistance effect, a blood vessel expansion effect, a blood pressure reduction effect, a coronary flow increment effect, an anti-myocardial ischemia effect, an anti-anoxia effect, an acute cerebral ischemia prevention effect, a remarkable anti-tumor effect in vitro and in vivo and the like.

The present invention comprises methods and systems for treating a cardiac arrhythmia in a mammal by administering gated or pulsed radiofrequency current or other ablative energy to the mammal during one or more time periods of increased coronary blood flow. Preferred embodiments of the invention comprise, without limitation, the gated or pulsed administration of radiofrequency current in association with the formation of the dicrotic notch in the arterial blood pressure curve of the mammal. In accordance with the invention, the thermal effects of ablative energy application on the coronary artery are avoided or mitigated due to rapid coronary blood flow resulting in heat loss and minimization of damage to blood vessels.

In a device for monitoring the heart cycle of a human heart such that coronary flow may be maintained at a desired level, and a heart stimulator including such a device, the monitoring device is connectable to a first sensor adapted to be positioned at a first location of the heart and arranged for sensing cardiac wall movements at the first location, and to a second sensor adapted to be positioned at a second location of the heart and arranged for sensing cardiac wall movements at said second location. Processing circuitry receives output signals from the first and second sensors, which output signals are indicative of myocardial relaxation at said first and second locations. The processing circuitry determines the time of myocardial relaxation at the first and second locations, and provides a diastolic synchronization signal indicative of the synchrony in the time of myocardial relaxation between the first location and the second location.

The present approach provides a non-invasive methodology for estimation of coronary flow and / or fractional flow reserve. In certain implementations, various approaches for personalizing blood flow models of the coronary vasculature are described. The described personalization approaches involve patient-specific measurements and do not assume or rely on the resting coronary flow being proportional to myocardial mass. Consequently, there are fewer limitations in using these approaches to obtain coronary flow and / or fractional flow reserve estimates non-invasively.

The present invention relates to a device and method for measuring a blood flow through a coronary system of a heart. It was realized that said blood flow causes a temporary change in the impedance of the coronary system, in the form of a peak in a first time-derivative of the impedance signal. The method comprises measuring an impedance signal across the body region containing the coronary system as a function of time, determining a first derivative of the impedance signal with respect to time, and calculating the blood flow from a peak height of a certain peak signal in said derivative impedance signal. The device comprises a bioimpedance measuring device adapted for the method.

The present approach provides a non-invasive methodology for estimation of coronary flow and / or fractional flow reserve. In certain implementations, various approaches for personalizing blood flow models of the coronary vasculature are described. The described personalization approaches involve patient-specific measurements and do not assume or rely on the resting coronary flow being proportional to myocardial mass. Consequently, there are fewer limitations in using these approaches to obtain coronary flow and / or fractional flow reserve estimates non-invasively.

Embodiments relate to non-invasively determining coronary circulation parameters during a rest state and a hyperemic state for a patient. The blood flow in the coronary arteries during a hyperemic state provides a functional assessment of the patient's coronary vessel tree. Imaging techniques are used to obtain an anatomical model of the patient's coronary tree. Rest boundary conditions are computed based on non-invasive measurements taken at a rest state, and estimated hyperemic boundary conditions are computed. A feedback control system performs a simulation matching the rest state utilizing a model based on the anatomical model and a plurality of controllers, each controller relating to respective output variables of the coronary tree. The model parameters are adjusted for the output variables to be in agreement with the rest state measurements, and the hyperemic boundary conditions are accordingly adjusted. The hyperemic boundary conditions are used to compute coronary flow and coronary pressure variables.

The present invention relates to a new-type insertion valve and other artificial valve in-vitro performance testing equipment. Said equipment includes the following several portions: pulsopump, a segment of artificial blood vessel, power system, variable temperature system and resistance system. Said invention also provides the connection mode of all the above-mentioned portions, and also provides the concrete operation method of said equipment.

The invention relates to a blood flow speed calculation method for the coronary artery based on a radiography image. The method comprises the following steps that a coronary artery radiography image sequence is acquired; each frame of the acquired coronary artery radiography image is divided and subjected to binaryzation, and a coronary artery tree is extracted; target blood vessel center lines are extracted from the coronary artery tree; according to the change condition of the lengths of the target blood vessel center lines of different frames, the average blood flow speed of a target bloodvessel in the filling stage is calculated through fitting.

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and / or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.

The invention discloses a heterophylly falsestarwort root health tea and a preparation method thereof, and the health tea is prepared by the following raw materials by weight: 40-60% of heterophylly falsestarwort root powder, 15-20% of medlar, 10-15% of arillus longan, 15-25% of osmanthus fragrans. Heterophylly falsestarwort root contains abundant polysaccharides, a plurality of essential amino acids, a plurality of trace elements and the like, is mainly used to treat spleen deficiency and tireness, anorexia, weakness after diseases, qi and yin deficiency, spontaneous perspiration and hydrodipsia, lung dryness and dry cough, palpitation and insomnia, deficiency heat and hyperidrosis; medlar has the efficacy of nourishing liver and kidney, nourishing liver and improving eyesight; arillus longan contains protein, fat, carbohydrates, organic acids, crude fibers, and a plurality of vitamins and mineral matter, and has the effects of improving body immunity, inhibiting tumor cells, reducing blood lipid, increasing blood flow of coronary artery, and enhancing body diathesis; osmanthus fragrans has the efficacy of relieving cough and resolving phlegm, preserving health and moistening lung. The health tea of the invention has a reasonable formula and synergistic effects, not only can be used as a tea drink, but also has nourishing and life-prolonging effects.

A Chinese medicine 'Xiangdan injection' for treating angina pectoris and myocardial infarction is prepared from red sage root and dalbergia wood through preparing the aromatic liquid by distilling dalbergia wood, preparing liquid extract of red sage root through depositing in alcohol and water, centrifugal separation and ultrafiltration, mixing them together, stirring, loading in containers and sterilizing.

The invention discloses mixed oil and fat capable of preventing and treating cardiovascular diseases. The mixed oil and fat consists of the following raw materials in parts by weight: 1-10 parts of fish oil, 1-10 parts of perilla herb oil, 1-10 parts of pomegranate seed oil, 12-80 parts of vegetable oil and fat, 0.9-1.5 parts of a stabilizing agent and 0.4-0.6 part of a fragrance additive, whereinthe weight ratio of EPA to DHA in the fish oil is (6-9) to 1, and the weight of the EPA and the DHA is 50-95% of that of the fish oil. The mixed oil and fat disclosed by the invention has notable treatment effects of preventing and treating the cardiovascular diseases; through scientific blending, the mixed oil and fat contains EPA, flavone, oryzanol, sterol, punicic acid, VE, phytosterol and thelike, has good treatment effects on heart and cerebral vessels, can regulate fat metabolism, can prevent and treat arteriosclerosis, can reduce blood cholesterol and blood viscosity, can restrain platelet aggregation and can improve blood circulation; and the mixed oil and fat can have the effects of reducing low-density protein, increasing high-density lipoprotein, recovering the elasticity of blood vessels, increasing the blood flow of coronary arteries, and preventing and treating arteriosclerosis and high blood pressure, so that the purposes of preventing and / or treating the cardiovascular diseases and particularly treating coronary heart diseases and the high blood pressure can be realized.

The invention discloses a medicinal composition for treating angina pectoris of coronary heart disease. The medicinal composition consists of the following raw material medicines: cassia twig, officinal magnolia bark, humifuse euphorbia herb, Mongolian dandelion herb, cape jasmine fruit, szechuan lovage rhizome, diverse wormwood herb, processed pinellia tuber, bitter orange, rhizome of swordlike atractylodes, root of lobed kudzuvine, myrrh, arisaema consanguineum schott, cassia seed, costustoot, thinleaf milkwort root-bark, motherwort herb, silktree albizzia bark, safflower, long pepper, szechwan chinaberry fruit, fortune eupatorium herb, panax notoginseng, bezoar, snakegourd fruit, nutgrass galingale rhizome, Chinese thorowax root, mulberry fruit, lychee seeds, lucid ganoderma, dragon's blood, grassleaf sweelflag rhizome, licorice root and cyrtomium rhizome. By adopting the medicinal composition disclosed by the invention, the attack times of angina pectoris of coronary heart disease can be effectively reduced, the attack duration of angina pectoris can be shortened, the occurrence of myocardial infarction can be avoided, sudden death caused by angina pectoris can be avoided, and adverse reactions cannot be caused; and the medicinal composition is accurate in curative effect and small in toxic or side effect, ensures that the cardiac stroke volume and cardiac output can be increased, cardiac indexes can be increased, the cardiac pumping functions can be enhanced, the ventricular diastolic functions and arterial compliance can be improved, coronary arteries can be expanded and the blood flow volume of the coronary arteries can be increased, and has significant curative effects on the aspect of treating angina pectoris of coronary heart disease.