6 results about "Coronary vessel" patented technology

This invention discloses a 3D-printed helical biodegradable anti-inflammatory vascular stent and its preparation method, belonging to the field of vascular stents. The invention uses multiple helical support wires arranged into a tubular shape, with the ends connected in a serpentine transitional manner. The helical support wires are connected by connecting ribs, and the surface is coated. This invention is biodegradable after use, avoiding the harm caused by permanent retention in the body, and has a lower restenosis rate compared to metal stents. The surface of the vascular stent is coated with a spermidine-containing coating to prevent immune rejection of the implanted vascular stent, thereby addressing the problems of inflammation and intimal hyperplasia. The helical structure facilitates contraction and expansion, has good bending flexibility, and the added connecting ribs increase the radial support performance of the vascular stent, better achieving the effect of vascular remodeling. This invention has significant implications in terms of biodegradability, anti-immune rejection, and mechanical properties, and can be used for treatment in different locations such as peripheral and coronary vessels.

The application belongs to the technical field of medicine, and particularly relates to application of acacetin or 6-hydroxyflavone in preparation of anti-angina pectoris drugs, and aims to solve the problems of adverse reactions such as blood pressure drop, reflex tachycardia and the like caused by non-selective vasodilation of existing anti-angina pectoris drugs, wherein the drug improves myocardial blood supply by selectively dilating coronary vessels of the heart, wherein acacetin dilates coronary vessels of the heart by inhibiting cardiac coronary vessel myosin light chain kinase and activating myosin light chain phosphatase, and 6-hydroxyflavone dilates coronary vessels of the heart by inhibiting protein kinase C and enhancing myosin light chain phosphatase activity; and the acacetin or 6-hydroxyflavone significantly reduces the symptoms of myocardial ischemia of rats caused by isopropyl adrenaline, improves characteristic ECG abnormal changes of angina pectoris, does not affect heart rate and systemic blood pressure, and is safer, thereby providing a potential drug selection for anti-angina pectoris treatment.

The application provides a non-invasive coronary blood flow evaluation method based on multi-phase CTA and Bayesian inference, comprising the following steps: acquiring multi-phase coronary CTA images of a target to be evaluated, and extracting coronary vessel deformation waveform data from the multi-phase coronary CTA images; generating posterior probability distribution estimation results of coronary blood flow rate through a pre-established Bayesian inference framework and the coronary vessel deformation waveform data; and generating coronary blood flow rate evaluation results corresponding to the target to be evaluated according to the posterior probability distribution estimation results. The application uses a Bayesian framework to simultaneously estimate multiple physiological parameters, and identifies parameter interactions through posterior correlation analysis, thereby improving inversion accuracy.

The application belongs to the technical field of medical images, and discloses a coronary vessel center line extraction method, device, equipment and storage medium. The method comprises the following steps: acquiring a coronary segmentation image and an aorta segmentation image, and detecting the coronary segmentation image to obtain a first left coronary starting point and a first right coronary starting point; performing inflation processing on the aorta segmentation image to obtain a target aorta segmentation image; performing intersection segmentation on the coronary segmentation image based on the target aorta segmentation image to obtain a final coronary segmentation image; detecting the final coronary segmentation image, and determining a left coronary end point and a right coronary end point after detecting a second left coronary starting point and a second right coronary starting point; and determining a left coronary vessel center line and a right coronary vessel center line based on the first left coronary starting point, the first right coronary starting point, the left coronary end point and the right coronary end point. In this way, the coronary vessel center line can be accurately extracted when the coronary vessel origin is abnormal.

This application provides a method, apparatus, and storage medium for calculating coronary artery calcium scores, comprising: segmenting an initial three-dimensional medical image of the cardiac region from a plain coronary CT image using an image segmentation model; identifying calcified plaque regions in the initial three-dimensional medical image to determine at least one target region image and the location information of each image; identifying the coronary vessel category in each image by recognizing the input consisting of the target region image and the image location information; performing overall recognition of the initial three-dimensional medical image using a second coronary classification model to determine the calcified plaque regions included in the initial three-dimensional medical image, the location information of each region, and the category of coronary vessels; and calculating the calcium score for the calcified regions identified by both models to obtain the total coronary artery calcium score. Thus, the method provided in this application can quickly and accurately calculate the coronary artery calcium score based on plain CT scans.