The invention relates to a bioengineering technology, in particular to a small-
caliber biotic artificial
blood vessel with anti-
thrombus formation and anti-
intimal hyperplasia functions. Firstly, the key technology of accellular materials and natural
polymer composition is used, and through
multiple modes,
neurotrophic factors are effectively coupled as functional modules to perform modification on
blood vessel supports. Furthermore, through the strategy of constructing in body, the small-
caliber engineering blood vessel modified by the
neurotrophic factors is transplanted in body, the scour and the pressure of
hemodynamics are overcome in body, endothelial
progenitor cells in circulation are captured initiatively, the endothelial
progenitor cells are further induced to differentiate into endothelial cells in situ, and the progress and the quality of endothelialization of blood vessel graft are speeded. Meanwhile, the generation of blood capillaries is promoted and nurtured, the blood vessel implants are promoted to remodel in body, therefore, the effects of anti-
thrombus formation and anti-
intimal hyperplasia can be effectively achieved, and the patency rate after the small-
caliber biotic artificial blood vessel is transplanted is increased. Active small-caliber
tissue engineering blood vessels used for coronary arterie
bypass grafting, hematodialysis and cerebrovascular replacement in clinic are built.