48 results about "Revascularization" patented technology

The invention discloses a thrombus excision system. An embolus is extracted through a mechanical embolus extraction device, a blood vessel is dredged, and revascularization of the blood vessel is achieved. A saccule guide catheter is put at the near end of the embolus part when the embolus is extracted, blood flow is temporarily blocked, and thus a fine crushed embolus generated in the embolus extraction process is prevented from being flushed to the far end of the blood vessel; meanwhile, for a relatively large embolus, a part of thrombus can also be sucked by virtue of the saccule guide catheter, and then the residual thrombus can be extracted by virtue of a thrombus exsector. The thrombus exsector, the saccule guide catheter and a delivery microcatheter are arranged on the thrombus excision system disclosed by the invention, wherein the thrombus exsector is used as a main component, an excision spring is arranged, and the release state of the excision spring is a conical spiral state. Compared with the prior art, the thrombus excision system has the advantages that the thrombus exsector is very soft, the minimal through size is 0.014' (0.36mm), the thrombus exsector can easily enter a cerebral vessel, a near-end protection technology is adopted in the operation process, and thrombus suction is combined with mechanical embolus extraction, so that the success rate of the operation is improved, and the complications are reduced.

Automated image analysis used in vascular state modeling. Coronary vasculature in particular is modeled in some embodiments. Methods of “virtual revascularization” of a presently stenotic vasculature are described; useful, for example, as a reference in disease state determinations. Structure and uses of a model which relates records comprising acquired images or other structured data to a vascular tree representation are described.

The invention provides a clinical diagnosis and treatment path generation method and system for tracking a chest pain patient. Wherein a dynamic spatio-temporal data atlas is constructed by synchronously collecting respiratory rhythm phase difference, coronary artery calcification integral and hypersensitive troponin curve slope, and risk degree transition signals are generated by coupling analysis of ST segment elevation amplitude asymmetric growth, left ventricular ejection fraction attenuation gradient and B-type natriuretic peptide release rate. In the acute stage, the constraint relation between a vascular recanalization time window and thrombolysis taboo is dynamically bound, in the subacute stage, a phase synchronization rule for enhancing CT scanning and anticoagulant drug dosage is established through a multidisciplinary interface, intravascular ultrasonic plaque morphological mutation characteristics and extracorporeal circulation parameters are fused, the blood supply reconstruction time sequence is dynamically adjusted based on a myocardial oxygen consumption balance equation, and the thrombolysis time sequence is determined. And path self-optimization is realized through space-time superposition of an interventional therapy delay parameter and a drug metabolism curve. According to the technical scheme provided by the invention, chest pain diagnosis and treatment path dynamic optimization and multi-modal parameter collaborative decision-making are realized, and the risk layering precision and the treatment timeliness are improved.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

The invention discloses an application of nitro fatty acid in preparation of a product for predicting, preventing and improving adverse cardiovascular events of patients with acute coronary syndrome. The invention provides application of nitro fatty acid in preparation of products for preventing and improving adverse cardiovascular events of ACS patients. According to the application, for the ACS patient, when the concentration of the 12-nitro conjugated linoleic acid in the body is larger than 0.196 ng / ml and the concentration of the 9-nitro conjugated linoleic acid is larger than 0.296 ng / ml, it is judged that the risk that the ACS patient is re-hospitalized and dead due to non-fatal myocardial infarction / unstable angina pectoris / blood supply reconstruction is low. By detecting the content of nitro fatty acid in a biological sample and supplementing nitro fatty acid, the occurrence rate of adverse events can be greatly reduced. Meanwhile, the invention further provides a detection method of nitro fatty acid, and the accuracy of biological sample detection is improved.

The invention discloses a temperature-controlled anti-inflammatory and antibacterial skin wound dressing capable of promoting revascularization and a preparation method and application thereof, and relates to the technical field of medical materials, the preparation method comprises the following steps: S1, preparing calcium peroxide microspheres; s2, the poloxamer 407, the chitosan and the forsythiaside A are jointly dissolved in an acetic acid solution, and mixed gel is obtained; s3, dispersing calcium peroxide microspheres into the mixed gel to obtain the skin wound dressing capable of controlling temperature, resisting inflammation and bacteria and promoting revascularization. The traditional Chinese medicine active ingredient forsythiaside A is loaded, so that the healing efficiency of diabetic wounds is improved; due to the temperature-sensitive property of the gel, the gel can be better attached to the wound, the antibacterial property can inhibit microorganism breeding at the wound surface, the oxygen release capacity can improve the anoxic environment at the wound, and the loaded traditional Chinese medicine active ingredient forsythiaside A has the anti-inflammatory capacity, promotes cell regeneration at the wound and accelerates the repair process.

The invention discloses a medicinal preparation for promoting healing of chronic diabetic wounds as well as a preparation method and application of the medicinal preparation, and relates to the technical field of medicinal preparations. According to the invention, a thrombin solution containing Se-CQDs and a fibrinogen solution containing GOX are mixed and reacted to prepare the pharmaceutical preparation for promoting healing of chronic wounds of diabetes. The pharmaceutical preparation for promoting healing of the chronic wound of diabetes can effectively remove excessive ROS at the chronic wound of diabetes and reduce the pH, glucose content and M1 / M2 macrophage proportion at the chronic wound, so that the high-glucose alkaline inflammation microenvironment of the chronic wound of diabetes is reversed, collagen deposition, revascularization and skin tissue reepithelization are promoted, and the healing of the chronic wound of diabetes is promoted. Therefore, healing of chronic diabetic wounds is promoted. Meanwhile, Se-CQDs and GOX are combined to prepare the pharmaceutical preparation, and the pharmaceutical preparation has a synergistic effect on promoting healing of chronic wounds of diabetes mellitus.

A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.

This invention discloses a magnetically controlled balloon guidewire for microvascular revascularization and its manufacturing method. The magnetically controlled balloon guidewire for microvascular revascularization includes a magnetically controlled tip, a phase-change balloon, and a guidewire connected in sequence. This magnetically controlled balloon guidewire for microvascular revascularization can precisely navigate and flexibly steer, and the phase-change balloon can accurately navigate to the stenotic lesion site of the microvessel.

The present invention provides extracellular vesicle compositions. Also provided are methods of making an extracellular vesicle loaded scaffold using the extracellular vesicle compositions to increase revascularization. Methods of using the extracellular vesicle compositions and the extracellular vesicle loaded scaffold are provided. The scaffold may increase blood flow and oxygenation of the tissue thereby aiding in treatment of disease and injury.

Provided herein are compositions including a CRISPR / dCas9-based demethylation cocktail targeting a methylated endothelial PLCγ2 promoter and methods of treating wounds using the same.

Reperfusion injury is limited during endovascular therapies (e.g., revascularization and / or reperfusion of end organ tissues) by conditioning the tissues against reperfusion injury using an optical fiber catheter to deliver far red and near infrared (R / NIR) light to the tissues. The light may be multiple wavelength or single wavelength light, and may have one or more wavelengths selected from the range of 510 to 830 nm. The R / NIR light may be delivered concurrently with the endovascular therapy, or in other instances may be delivered before or after a particular therapy.

The subject invention pertains to a novel method for treating Peripheral Arterial Disease (PAD) by leveraging the angiogenic potential oftype 2 cytokines IL-4 and IL-13 to enhance the efficacy of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) and induced endothelial cells derived from fibroblasts (iECs). This present invention aims at enhancing the muscle regeneration and revascularization for obese and diabetes individuals.

The invention discloses a post-AMI heart failure oxidized lipid screening method based on solid phase extraction, LC-MS / MS and AI. The method comprises the steps of blood sample pretreatment, solid phase extraction and purification, LC-MS / MS detection and AI model screening. According to the method, high-sensitivity qualitative and quantitative detection of oxidized lipid is realized through optimized LC-MS / MS parameters, and key oxidized lipid molecules and risk levels of heart failure after AMI emergency treatment blood supply reconstruction can be quickly and accurately screened in combination with a trained random forest AI model; the kit solves the problems that in the prior art, trace oxidized lipid detection sensitivity is low, specificity is poor, and heart failure risk screening lags, has the advantages of being high in detection efficiency, good in accuracy and high in practicability, can provide a scientific basis for early warning and intervention of clinical heart failure after AMI, and has high clinical application value.

Processes are provided based on an interventional (device-based) approach to minimize the development of intramyocardial hemorrhage within the myocardial infarction (MI) zone. In one exemplary process, the revascularization occurs in an incremental fashion prior to fully opening the vessel, so as to modulate the hydrostatic pressure transmitted from the proximal end of the catheter, prior to placing a stent. In another exemplary process, the stent will be placed within the central core of the embolization and will slowly expand within the lumen reaching full patency over a period of time. Devices operated with these processes can also greatly reduce the chance of development of intramyocardial hemorrhage with the MI zone. These developments can improve the outcome in hemorrhagic patients, who otherwise carry a significant risk for heart failure and sudden death.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

This invention provides a blood revascularization monitoring device and method. The blood revascularization monitoring device includes: a light source and a photoelectric sensor disposed on a housing; both the light source and the photoelectric sensor are electrically connected to a main control board inside the housing; the light source includes a first light-emitting diode; the photoelectric sensor includes a first receiver and a second receiver; the first receiver and the second receiver, together with the first light-emitting diode, form a first monitoring channel for monitoring blood oxygen data; the line connecting the first receiver and the second receiver forms a triangle with the projection of the first monitoring channel onto the bottom surface of the housing. This invention facilitates accurate monitoring of blood circulation status.

A system for removing a thrombus in a blood vessel, includes: a main body part which is movable along the blood vessel and performs a revascularization function within the blood vessel during installation, and sucks and transfers the thrombus during aspiration; a microflow circuit part which is attached to the outer surface of the main body part and extends to the exterior of the body, creates a microflow circuit which acts on the thrombus to move, deform, and fragment the thrombus; and an aspiration part which is provided to the exterior of the body from the inside of the blood vessel, and which during aspiration, after blocking blood flow in the blood vessel, aspirates the thrombus which has been moved, deformed and fragmented by the microflow circuit part and transferred by the main body part and discharges the thrombus to the outside of the body.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.

Methods of using pulsed focused ultrasound (pFUS) therapy to treat pancreatic disorders such as type 1 diabetes, pancreatitis, and pancreatic cancer are provided. The methods utilize pulsed focused ultrasound (pFUS) therapy either by itself or in combination with islet transplantation and / or stem cell therapy to promote regeneration of damaged pancreatic tissue, increase insulin secretion in response to glucose, or improve engraftment and revascularization of transplanted islets or beta cells. Additionally, methods of using pFUS are provided for modulating paracrine secretion in the pancreas, islets, beta cells, or stem cells, or at a transplantation site to therapeutically alter levels of various factors including, without limitation, cytokines, growth factors, angiogenic factors, and cell adhesion molecules.

The present disclosure relates to compositions comprising phospholipids, lipid vesicles, and / or liposomes, and methods of use thereof. In one aspect, the present disclosure relates to methods and compositions for delivery of, biologically active lipids to reduce microvascular dysfunction and infarct size during revascularization of the blocked artery in a mammalian subject.

Systems and methods for PCI post-operative coronary artery analysis. One example method includes acquiring a plurality of angiographic images depicting at least one blood vessel of a patient's heart, the angiographic images including two or more percutaneous coronary intervention (PCI post-operation) images depicting a PCI site where a PCI is included to perform a blood supply reconstruction of a lesion, and one or more diagnostic images depicting at least one blood vessel of the patient's heart, the PCI post-operation images depicting the PCI site where the PCI is included to perform a blood supply reconstruction of the lesion. And wherein the diagnostic image depicts a lesion; receiving a user input specifying a PCI site in the PCI post-operation image via a user interface presenting the PCI post-operation image; determining an indicator indicative of vascular function based on the angiographic image, where the indicator is derived based on a three-dimensional model of portions of the patient's heart, and where portions of the diagnostic image depicting the lesion are masked during generation of the three-dimensional model; and presenting, via a user interface, summary information associated with the PCI, the summary information including at least the determined indicator.

The invention provides a hydrogel dressing capable of promoting revascularization of diabetic wound surfaces as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of biomedical materials. The hydrogel dressing capable of promoting the vascular regeneration of the diabetic wound surface, provided by the invention, is prepared from the following raw materials: a mesenchymal stem cell exosome of miR-221-3p with an overexpression nucleotide sequence as shown in SEQ ID NO.1, and gelatin methylacryloyl hydrogel; the volume ratio of the mesenchymal stem cell exosome (100 [mu] g / mL) to the gelatin methylacryloyl hydrogel (15% mass-volume fraction) is (0.5-3): 9. The hydrogel dressing provided by the invention can generate gel state transition at a wound under the action of ultraviolet light, can promote the vascular regeneration of a diabetic wound surface from a molecular level, has good biocompatibility, photoresponsiveness and mechanical characteristics, and provides a guarantee for maximizing the treatment effect of the engineered exosome.

The present invention discloses the application of angiopoietin receptor Tie-2 as a biomarker for the diagnosis of moyamoya disease. Detecting the level of soluble Tie-2 protein in human peripheral blood can diagnose patients with moyamoya disease and cerebral atherosclerotic occlusion, and predict the postoperative revascularization effect of moyamoya disease patients. The present invention provides a new means for the clinical diagnosis of moyamoya disease and predicting the prognosis of patients, and has important clinical value and application prospects for popularization.

The invention discloses a magnetic control balloon guide wire for blood supply reconstruction of a micro blood vessel and a manufacturing method of the magnetic control balloon guide wire. The magnetic control balloon guide wire for blood supply reconstruction of the micro blood vessel comprises a magnetic control end, a phase change balloon and a guide wire body which are connected in sequence. The magnetic control balloon guide wire for blood supply reconstruction of the micro blood vessel can be accurately navigated and flexibly steered, and the phase change balloon can be accurately navigated to the narrow lesion position of the micro blood vessel.

The invention relates to a preparation method of an oral keratinized gingival regeneration and repair stent and a product thereof, and the preparation method comprises the following steps: sequentially treating an acellular matrix with a first modifier, a fixing agent and a second modifier to obtain an enhanced acellular matrix; mixing the carrier solution with the antibacterial natural product solution, dropwise adding an ionic cross-linking agent, and centrifuging to obtain a precipitate, namely the drug-loaded nanoparticles; and mixing the enhanced acellular matrix, the drug-loaded nanoparticles and the covalent linking agent, washing with water, and freeze-drying to obtain the drug-loaded enhanced acellular matrix. The repair stent prepared by the invention has excellent biocompatibility, long-term stable degradation, outstanding antibacterial and anti-inflammatory effects and good mechanical properties, and can promote wound healing and revascularization.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a variable occluder for implantation in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction. Following venous system compensation, oxygenated blood flow is shunted into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

The invention provides a branch stent system for reconstructing a visceral artery, and relates to the technical field of vascular intervention medical instruments, the branch stent system comprises a main stent module, the main stent module is provided with a side hole structure, and the side hole structure adaptively adjusts the size of an interface according to the diameter of a branch blood vessel; the branch support module is provided with a connecting structure, and the branch support module and the side hole structure form a connecting channel; and the conveying module comprises a conveying catheter and a release mechanism, and the conveying catheter bears and conveys the branch stent module. According to the branch stent system for reconstructing the visceral artery, accurate butt joint of the branch stent and the main stent is ensured by adjusting the size of the connector in a self-adaptive mode and adjusting the implanting angle and the releasing position in real time, the problems of deviation, untight attachment and the like caused by blood vessel anatomy difference in the prior art are solved, and the safety and the success rate of an operation are improved.

The invention relates to the technical field of biological medicine, and discloses an exosome preparation for treating thin endometrium and a preparation method thereof, and the preparation method comprises the following steps: step 1, culturing mesenchymal stem cells; step 2, extracting an exosome; step 3, preparing a collagen solution; step 4, preparing traditional Chinese medicine components; and step 5, uniformly stirring the collagen solution and the sheep placenta powder extracting solution under the condition of 4 DEG C, then adding the exosome solution, mixing, then adding the soy isoflavone solution and auxiliary materials, fully reacting to obtain exosome gel, and storing under the condition of 4 DEG C. According to the exosome preparation for treating the thin endometrium and the preparation method of the exosome preparation, collagen gel is used as a slow-release matrix, three-dimensional structure support is provided for active substances, degradation of the active substances is slowed down, meanwhile, growth factors in the sheep fetus powder extracting solution and the exosome act together, revascularization is activated, blood supply is improved, and the effect of treating the thin endometrium is achieved. The regrowth of the endometrium is promoted.