220 results about "Revascularization" patented technology

A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

A system and method for opening a lumen in an occluded blood vessel, e.g., a coronary bypass graft, of a living being. The system comprises an atherectomy catheter having a working head, e.g., a rotary impacting impeller, and a debris extraction sub-system. The atherectomy catheter is located within a guide catheter. The working head is arranged to operate on, e.g., impact, the occlusive material in the occluded vessel to open a lumen therein, whereupon some debris may be produced. The debris extraction sub-system introduces an infusate liquid at a first flow rate adjacent the working head and withdraws that liquid and some blood at a second and higher flow rate, through the guide catheter to create a differential flow adjacent the working head, whereupon the debris is withdrawn in the infusate liquid and blood for collection outside the being's body. The introduction of the infusate liquid may also be used to establish an unbalanced flow adjacent the working head to enable the atherectomy catheter to be steered hydrodynamically. A guide wire having an inflatable balloon on its distal end may be used with the atherectomy catheter to block the flow of debris distally, while enabling distal tissues to be perfused with an oxygenating liquid. At least one flow control port may be provided in the guide catheter to prevent collapse of the vessel being revascularized. A cradle is provided to fix the guide catheter and guide wire in position within the body of the being while enabling the atherectomy catheter to be advanced along the guide wire and through the guide catheter.

Methods, devices, and systems for a) revascularization and / or b) performing other medical procedures at vascular or non-vascular intracorporeal locations within a mammalian body. The methods generally comprise the formation of at least one extravascular passageway from a blood vessel to a vascular or non-vascular target location. In the revascularization methods the extravascular passageway is utilized for blood flow. In the medical procedure methods the extravascular passageway is utilized as a conduit for accessing or performing procedures at the vascular or non-vascular target location. Also disclosed are catheter devices and systems which are useable to form the extravascular passageways of the invention, as well as apparatus for modifying, maintaining and / or closing such extravascular passageways.

An endograft for a vessel having a vascular branch extending from the vessel is provided. The endograft includes a main body having a wall separating interior and exterior surfaces and adapted to be inserted within the vessel. The main body is characterized by a single proximal opening and a single terminal opening and at least one aperture extending through the wall. At least one stent is secured to the main body that upon expansion pressure fits the main body into the vessel. An open tunnel is secured to the interior surface of the main body around the main body aperture and secured somewhere along the tunnel length to provide fluid communication between the interior and exterior surfaces of the main body through the aperture and with the vascular branch in proximity to the main body aperture. The tunnel is readily formed independent of an expandable stent. Through the addition of further apertures and tunnels, an endograft is well suited for revascularizing the superior mesenteric artery and renal arteries for the treatment of a suprarenal aortic aneurysm. The insertion of a sleeve positioned partly within the tunnel and extending beyond the exterior surface of the main body into the vascular branch assures continued fluid flow to the vascular branch.

The present invention relates to methods and systems for performing intralumenal procedures including revascularization and removal of foreign objects from a body lumen. More particularly the present invention relates to systems utilizing thrombectomy devices and methods of performing medical procedures to remove thrombus, emboli, foreign objects and or re-establish the intravascular flow of blood.

A self expanding flexible or balloon expandable flexible device includes a helical strut member helically wound about an axis of the stent. The helical strut member comprises a plurality of helical strut elements. A plurality of individual helical elements are helically wound about the axis of the device in the same direction of the helical strut member with the helical elements extending between and interconnecting points on subsequent windings of the helical strut member. The device can be a flow diverter, anchor, revascularization device or filter. A self expanding flexible bifurcation device can include at least one leg. The at least one leg comprising the helical strut member and the plurality of individual helical elements helically wound about the axis of the device in the same direction of the helical strut member with the helical elements extending between and interconnecting points on subsequent windings of the helical strut member.

The present invention relates to a carrnulated microfracture kit, apparatus, and method for using the same during a medical treatment. The present kit enables precise and repeated positioning, the regulation and repetition of microfracture force application, and a control of a mosaic bone penetration and other surgical control improvement features. The present invention overcomes the detriments resultant from prior techniques in an apparatus that is readily adaptable to a variety of adaptive orthopedic surgical procedures. Assembled and selectable kits are provided.

Diffuse optical flow (DOF) sensors can be used to assess deep tissue flow. DOF sensors positioned on a foot can provide fluctuating light intensity data to an analyzer, which can then determine absolute and / or relative blood flow. The determined absolute and / or relative blood flow can be signaled to an operator, for example a surgeon for intra-operative use. DOF sensors may be utilized to assess pedal revascularization, for example to guide interventional procedures and to evaluate their efficacy. A support structure can carry a plurality of DOF sensors, such that when the support structure is placed onto a patient's foot, the DOF sensors are disposed adjacent different locations on the foot. The different locations may correspond to different topographical regions of the foot, for example different pedal angiosomes.

Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to a living subject for preventing organ ischemia or reperfusion injury. The methods and compositions disclosed herein can be used in such procedures as cardiac surgery, non-surgical cardiac revascularization, organ transplantation, perfusion, ischemia, reperfusion, ischemia-reperfusion injury, oxidant injury, cytokine induced injury, shock induced injury, resuscitations injury or apoptosis.

Disclosed herein, among other things, is a system for providing pacing during revascularization. An embodiment of the system includes an angioplasty or stent delivery catheter system having a catheter, a balloon and an inflation device adapted to inflate and deflate the balloon for delivery of a stent. The embodiment also includes a programmable pulse generator and at least one electrode integrated with the angioplasty catheter system, where the pulse generator is connected to the electrode. In various embodiments, at least one integrated sensor is connected to the angioplasty catheter system. The sensor is adapted to sense a parameter indicative of flow restoration and trigger the pulse generator to begin pacing based on the parameter.

The present invention provides methods of promoting the revascularization and / or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel.

Cardiac protection pacing is applied to prevent or reduce cardiac injury and / or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and / or after the ischemic event.

Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.

The described invention provides pharmaceutical compositions for treating an infarct area injury and methods of treating or repairing the infarct area injury in a revascularized subject in the aftermath of an acute myocardial infarction resulting from a natural disease process by administering to the subject parenterally through a catheter a sterile pharmaceutical composition containing a therapeutically effective amount of a nonexpanded sterile isolated chemotactic hematopoietic stem cell product as a first therapeutic agent and optionally a therapeutically effective amount of at least one compatible second therapeutic agent. The infarct area-improving amount of the sterile isolated chemotactic hematopoietic stem cell product comprises an enriched population of isolated autologous CD34+ cells containing a subpopulation of potent cells expressing CXCR-4 and having CXCR-4-mediated chemotactic activity such that the enriched population of isolated autologous CD34+ hematopoietic stem cells provides at least 0.5×106 potent CD34+ cells expressing CXCR-4 and having CXCR-4 mediated chemotactic activity.

This multi-bladed scalpel addresses the problem of making many small incisions in very close proximity (as close as 0.030'' / 0.75 mm) to each other, to facilitate hair transplantation. With this device, it is possible to make multiple incisions in such proximity. With the blades mounted parallel to each other, at the desired spacing, each incision does not intersect neighboring incisions, so the follicles placed in each incision will be surrounded by the maximum amount of undisturbed tissue to promote revascularization-capillary growth to provide a blood supply to each transplanted follicle. CNC machining techniques are used to create the blade holders with blade mounting sites created at the desired proximity. Medical grade epoxy is used to mount the blades, which are mounted parallel to each other. Holes are drilled so the tips of the blade group are located in a plane at an angle with respect to the blade holder for ergonomic reasons

Methods of treating, reducing the incidence of, and / or preventing an ischemic event in a patient undergoing percutaneous coronary intervention (PCI), comprising administering to the patient a pharmaceutical composition comprising cangrelor. The method may further comprise administering an additional therapeutic agent to the patient, the additional therapeutic agent comprising a P2Y12 inhibitor. Pharmaceutical compositions useful for treating, reducing the incidence of, and / or preventing an ischemic event in a patient undergoing PCI. The pharmaceutical compositions comprise cangrelor. Methods of preparing a pharmaceutical composition for treating, reducing the incidence of, and / or preventing an ischemic event in a patient undergoing PCI, comprising admixing cangrelor with one or more pharmaceutically acceptable excipients. An ischemic event may include stent thrombosis, myocardial infarction, ischemia-driven revascularization, and mortality.

Methods of regulating angiogenesis, ischemic injury and / or wound healing by modulating the activity of leptin, particularly as mediated by the leptin receptor, and / or the interaction between leptin and the leptin receptor. Correspondingly, these methods can also be used to treat diseases mediated by angiogenesis, including wound healing, tumors and tumor metastasis, diabetic microangiopathy, retinal neovascularization, neovascularization of adipose tissue and fat metabolism, revascularization of necrotic tissue, enhancement or vascularization in microvascular transplants, and ovarian follicle maturation. Assays for identifying agents that modulate leptin and / or leptin receptor-mediated angiogenesis and / or wound healing and their use in treating angiogenesis-mediated diseases or conditions involving wound healing are also disclosed.

The invention provides a repair material for biological derivative tendon. The material takes homogeneous or heterogeneous tendon as a raw material and is formed through disinfection, degreasing, deproteinization, decellularization, freeze drying, depolymerization, devillication recombination and secondary disinfection. A method for preparing a tendon scaffold material comprises the following steps that: on one hand, a periphery structure of a tendon tissue is destructed through treatment processes of removing soft tissues, the disinfecting, the degreasing and the decellularization, and the repellency of a transplantation receipt to the tendon is reduced; on the other hand, a basic mechanism, partial enzyme activity of the tendon tissue and the continuity of the tendon tissue are further maintained through a freeze drying process so as to provide a good scaffold structure for the revascularization and cell tissue of the tendon.

An improved medical device for revascularization of vascular occlusion and method for using same. The improved device includes a first catheter with a central lumen or guide wire capable of creating a channel within the CTO, and having a magnetic connection tip. One or more magnets or magnetic alignment elements are secured within or on the catheter connection tip to provide the desired positioning or straight line alignment of the catheter tip with respect to a second guide wire. The second guide wire includes a magnetic connection tip, with one or more magnets or magnetic alignment elements secured within or on the wire connection tip. The magnets or magnetic alignment elements on each connection tip are arranged such that opposite polarity magnets are used to attract the magnetic tips and their respective wire or catheter into the occlusion or subintimal space and into a close proximity position and alignment within the vessel to enable the use of mechanical elements, wires, energy sources, laser sources, or combinations of thereof, to assist in crossing the occlusion by creating a channel.

The present invention provides methods of promoting the revascularization and / or reenervation of central nervous system lesions using an in-situ crosslinkable hydrogel. The present invention also provides methods of treating a spinal cord injury by topically delivering to the spinal cord injury site a vehicle comprising a neurotrophic factor and / or anti-inflammatory agent. Also provided are methods of treating a spinal cord injury by topically administering or delivering a hydrogel to the injury site.

The invention provides automated apparatus and methods for manufacturing implantable tissue grafts in an operating room setting, preferably utilizing autologous adipose tissue cells for preparing vascular grafts. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a biochamber which supports a graft substrate. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases. The invention also provides methods biochamber configurations for applying a sustained low pressure gradient across a permeable scaffold material using a media containing cells to be deposited on the scaffold for the production of tissue grafts, including, but not limited to, vascular grafts.

The invention discloses a micro-invision intervened thrombus taking system, which comprises a conveyor guide wire, a thrombus catching device, a microcatheter and a guide catheter; the thrombus catching device is a net-shaped bracket formed by knitting one or more wires, a remote end of the bracket is closed or necked, a near end thereof is opened and in the shape of cone. The net-shaped bracket can sleeve relatively big main thrombus and also catch stripped small thrombus, so as to prevent small thrombus flowing to the blood vessel at remoter end and largely reduce the possibility of secondary stroke. The head end of the guide catheter is soft and can be expanded by the thrombus to obtain larger thrombus. The fracture resistance and the flexibility of the remote end of the guide catheter are largely improved, therefore, the guide catheter can be conveyed to the blood vessel at remoter end. The net-shaped bracket is also used as a bracket and reserved in a narrow-section blood vessel to expand the blood vessel and dredge the blood flow, therefore, the additional function of the disease is eased. By using the system, the operation time can be saved to win the treatment time for patients with acute cerebral apoplexy stoke, thus the success rate of the revascularization of the patients is improved.

The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.

The invention discloses a thrombus cutting system. The method is that a mechanical thrombus picking device is used for picking out thrombus and dredging vessel so as to achieve revascularization; when picking out thrombus, a ball bag guide catheter is positioned at the near end of the thrombus blocking position to temporarily block blood, in order to prevent small crushed thrombus caused by thrombus picking out is flushed by blood to the far end of vessel; meanwhile, part of thrombus with large size is pumped through the ball bag guide catheter, and then the rest thrombus is picked out through a thrombus cutter. According to the system, the thrombus cutter, the ball bag guide catheter and a micro conveying catheter are arranged; the thrombus cutter is used as a main assembly and provided with a cutting spring which is of a tapered spiral shape in a releasing state; compared with the prior art, the thrombus cutter is soft and the minimum passing size is 0.014'(0.36mm), so that the thrombus cutter can easily enter the blood vessel of brain; the near end protection technology is carried out during the operation; the thrombus pumping and mechanical picking out are combined, and therefore, the operation success rate is increased, and the complication is reduced.

A pacing system includes a pacemaker and a pacing protocol module externally attached to the pacemaker. The pacing protocol module stores the pacing protocol. The pacemaker controls delivery of pacing pulses by automatically executing the pacing protocol. In one embodiment, the pacing protocol is a cardioprotective pacing protocol for preventing and / or reducing cardiac injury associated with myocardial infarction (MI) and revascularization procedure. The pacing pulses are generated from the pacemaker and delivered through one or more pacing electrodes incorporated onto one or more percutaneous transluminal vascular intervention (PTVI) devices during the revascularization procedure.