29 results about "Revascularization" patented technology

The invention discloses a thrombus excision system. An embolus is extracted through a mechanical embolus extraction device, a blood vessel is dredged, and revascularization of the blood vessel is achieved. A saccule guide catheter is put at the near end of the embolus part when the embolus is extracted, blood flow is temporarily blocked, and thus a fine crushed embolus generated in the embolus extraction process is prevented from being flushed to the far end of the blood vessel; meanwhile, for a relatively large embolus, a part of thrombus can also be sucked by virtue of the saccule guide catheter, and then the residual thrombus can be extracted by virtue of a thrombus exsector. The thrombus exsector, the saccule guide catheter and a delivery microcatheter are arranged on the thrombus excision system disclosed by the invention, wherein the thrombus exsector is used as a main component, an excision spring is arranged, and the release state of the excision spring is a conical spiral state. Compared with the prior art, the thrombus excision system has the advantages that the thrombus exsector is very soft, the minimal through size is 0.014' (0.36mm), the thrombus exsector can easily enter a cerebral vessel, a near-end protection technology is adopted in the operation process, and thrombus suction is combined with mechanical embolus extraction, so that the success rate of the operation is improved, and the complications are reduced.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

This invention discloses a magnetically controlled balloon guidewire for microvascular revascularization and its manufacturing method. The magnetically controlled balloon guidewire for microvascular revascularization includes a magnetically controlled tip, a phase-change balloon, and a guidewire connected in sequence. This magnetically controlled balloon guidewire for microvascular revascularization can precisely navigate and flexibly steer, and the phase-change balloon can accurately navigate to the stenotic lesion site of the microvessel.

The subject invention pertains to a novel method for treating Peripheral Arterial Disease (PAD) by leveraging the angiogenic potential oftype 2 cytokines IL-4 and IL-13 to enhance the efficacy of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) and induced endothelial cells derived from fibroblasts (iECs). This present invention aims at enhancing the muscle regeneration and revascularization for obese and diabetes individuals.

The invention discloses a post-AMI heart failure oxidized lipid screening method based on solid phase extraction, LC-MS / MS and AI. The method comprises the steps of blood sample pretreatment, solid phase extraction and purification, LC-MS / MS detection and AI model screening. According to the method, high-sensitivity qualitative and quantitative detection of oxidized lipid is realized through optimized LC-MS / MS parameters, and key oxidized lipid molecules and risk levels of heart failure after AMI emergency treatment blood supply reconstruction can be quickly and accurately screened in combination with a trained random forest AI model; the kit solves the problems that in the prior art, trace oxidized lipid detection sensitivity is low, specificity is poor, and heart failure risk screening lags, has the advantages of being high in detection efficiency, good in accuracy and high in practicability, can provide a scientific basis for early warning and intervention of clinical heart failure after AMI, and has high clinical application value.

Processes are provided based on an interventional (device-based) approach to minimize the development of intramyocardial hemorrhage within the myocardial infarction (MI) zone. In one exemplary process, the revascularization occurs in an incremental fashion prior to fully opening the vessel, so as to modulate the hydrostatic pressure transmitted from the proximal end of the catheter, prior to placing a stent. In another exemplary process, the stent will be placed within the central core of the embolization and will slowly expand within the lumen reaching full patency over a period of time. Devices operated with these processes can also greatly reduce the chance of development of intramyocardial hemorrhage with the MI zone. These developments can improve the outcome in hemorrhagic patients, who otherwise carry a significant risk for heart failure and sudden death.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

This invention provides a blood revascularization monitoring device and method. The blood revascularization monitoring device includes: a light source and a photoelectric sensor disposed on a housing; both the light source and the photoelectric sensor are electrically connected to a main control board inside the housing; the light source includes a first light-emitting diode; the photoelectric sensor includes a first receiver and a second receiver; the first receiver and the second receiver, together with the first light-emitting diode, form a first monitoring channel for monitoring blood oxygen data; the line connecting the first receiver and the second receiver forms a triangle with the projection of the first monitoring channel onto the bottom surface of the housing. This invention facilitates accurate monitoring of blood circulation status.

Ischemic heart disease is a leading cause of death and reduced quality of life worldwide. Although revascularization strategies significantly reduce mortality after acute myocardial infarction (MI), many patients with MI develop chronic heart failure over time. We previously reported that human recombinant ANGPTL4 counteracts ischemia-induced vascular endothelial growth factor signaling and disruption of endothelial cell-cell adhesion, thereby inhibiting vascular permeability. We were able to demonstrate that ANGPTL4 administration before MI resulted in protection of the coronary capillary network, no-reflow syndrome, and reduced infarct size in mice. We also demonstrated that the therapeutic effects observed with ANGPTL4 under ischemic conditions were caused by the FLD fragment, not the CCD fragment (WO 2016 / 110498). To further examine the therapeutic potential of the FLD fragment of ANGPTL4 at the onset of reperfusion, we herein used a porcine model, a clinically relevant model of acute myocardial infarction that can be easily and safely translated into patient treatment. We demonstrated that local (antegrade) delivery of the FLD ANGPTL4 to infarcted porcine hearts can efficiently target the lesion site in a clinically relevant manner. A single administration of the FLD of ANGPTL4 improved cardiac function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. Short-term MI experiments, coupled with complementary mouse studies, demonstrated myocardial protection. Thus, a single administration of the FLD of ANGPTL4 can reduce ischemia-reperfusion injury and protect against adverse postischemic cardiac remodeling and subsequent ischemic heart failure.

The present disclosure relates to compositions comprising phospholipids, lipid vesicles, and / or liposomes, and methods of use thereof. In one aspect, the present disclosure relates to methods and compositions for delivery of, biologically active lipids to reduce microvascular dysfunction and infarct size during revascularization of the blocked artery in a mammalian subject.

Systems and methods for PCI post-operative coronary artery analysis. One example method includes acquiring a plurality of angiographic images depicting at least one blood vessel of a patient's heart, the angiographic images including two or more percutaneous coronary intervention (PCI post-operation) images depicting a PCI site where a PCI is included to perform a blood supply reconstruction of a lesion, and one or more diagnostic images depicting at least one blood vessel of the patient's heart, the PCI post-operation images depicting the PCI site where the PCI is included to perform a blood supply reconstruction of the lesion. And wherein the diagnostic image depicts a lesion; receiving a user input specifying a PCI site in the PCI post-operation image via a user interface presenting the PCI post-operation image; determining an indicator indicative of vascular function based on the angiographic image, where the indicator is derived based on a three-dimensional model of portions of the patient's heart, and where portions of the diagnostic image depicting the lesion are masked during generation of the three-dimensional model; and presenting, via a user interface, summary information associated with the PCI, the summary information including at least the determined indicator.

The invention provides a hydrogel dressing capable of promoting revascularization of diabetic wound surfaces as well as a preparation method and application of the hydrogel dressing, and belongs to the technical field of biomedical materials. The hydrogel dressing capable of promoting the vascular regeneration of the diabetic wound surface, provided by the invention, is prepared from the following raw materials: a mesenchymal stem cell exosome of miR-221-3p with an overexpression nucleotide sequence as shown in SEQ ID NO.1, and gelatin methylacryloyl hydrogel; the volume ratio of the mesenchymal stem cell exosome (100 [mu] g / mL) to the gelatin methylacryloyl hydrogel (15% mass-volume fraction) is (0.5-3): 9. The hydrogel dressing provided by the invention can generate gel state transition at a wound under the action of ultraviolet light, can promote the vascular regeneration of a diabetic wound surface from a molecular level, has good biocompatibility, photoresponsiveness and mechanical characteristics, and provides a guarantee for maximizing the treatment effect of the engineered exosome.

The invention relates to a preparation method of an oral keratinized gingival regeneration and repair stent and a product thereof, and the preparation method comprises the following steps: sequentially treating an acellular matrix with a first modifier, a fixing agent and a second modifier to obtain an enhanced acellular matrix; mixing the carrier solution with the antibacterial natural product solution, dropwise adding an ionic cross-linking agent, and centrifuging to obtain a precipitate, namely the drug-loaded nanoparticles; and mixing the enhanced acellular matrix, the drug-loaded nanoparticles and the covalent linking agent, washing with water, and freeze-drying to obtain the drug-loaded enhanced acellular matrix. The repair stent prepared by the invention has excellent biocompatibility, long-term stable degradation, outstanding antibacterial and anti-inflammatory effects and good mechanical properties, and can promote wound healing and revascularization.

The invention provides a branch stent system for reconstructing a visceral artery, and relates to the technical field of vascular intervention medical instruments, the branch stent system comprises a main stent module, the main stent module is provided with a side hole structure, and the side hole structure adaptively adjusts the size of an interface according to the diameter of a branch blood vessel; the branch support module is provided with a connecting structure, and the branch support module and the side hole structure form a connecting channel; and the conveying module comprises a conveying catheter and a release mechanism, and the conveying catheter bears and conveys the branch stent module. According to the branch stent system for reconstructing the visceral artery, accurate butt joint of the branch stent and the main stent is ensured by adjusting the size of the connector in a self-adaptive mode and adjusting the implanting angle and the releasing position in real time, the problems of deviation, untight attachment and the like caused by blood vessel anatomy difference in the prior art are solved, and the safety and the success rate of an operation are improved.

The invention relates to the technical field of biological medicine, and discloses an exosome preparation for treating thin endometrium and a preparation method thereof, and the preparation method comprises the following steps: step 1, culturing mesenchymal stem cells; step 2, extracting an exosome; step 3, preparing a collagen solution; step 4, preparing traditional Chinese medicine components; and step 5, uniformly stirring the collagen solution and the sheep placenta powder extracting solution under the condition of 4 DEG C, then adding the exosome solution, mixing, then adding the soy isoflavone solution and auxiliary materials, fully reacting to obtain exosome gel, and storing under the condition of 4 DEG C. According to the exosome preparation for treating the thin endometrium and the preparation method of the exosome preparation, collagen gel is used as a slow-release matrix, three-dimensional structure support is provided for active substances, degradation of the active substances is slowed down, meanwhile, growth factors in the sheep fetus powder extracting solution and the exosome act together, revascularization is activated, blood supply is improved, and the effect of treating the thin endometrium is achieved. The regrowth of the endometrium is promoted.

The embodiment of the invention provides a monitoring and early warning system after cerebral apoplexy vascular recanalization and a computer device. Comprising an acquisition module for acquiring a first neural electrophysiological data set and a second neural electrophysiological data set; the first processing module is used for obtaining a first damage level representing the preoperative neural function damage degree of the patient according to the difference between the first affected side physiological data and the first uninjured side physiological data at the same time point in the first neural electrophysiological data set; the second processing module is used for obtaining a second damage level representing the postoperative neurological function damage degree of the patient according to the difference between the second affected side physiological data and the second uninjured side physiological data at the same time point in the second neural electrophysiological data set; and the prediction module is used for predicting a prediction result representing the incidence probability of each complication in the postoperative prediction time period. The occurrence risk of postoperative complications of vascular recanalization can be predicted through contrastive analysis of the neural electrophysiological data of the affected side / uninjured side before the operation and the postoperative operation.

The invention provides injectable bionic heterostructure short fiber microspheres as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the invention, the injectable bionic heterostructure short fiber microsphere is constructed as an artificial microossification center for the first time, the short fiber microsphere has good biocompatibility, and after in-vivo in-situ injection, the short fiber microsphere interacts with an extracellular matrix through a surface three-dimensional fiber network bionic structure to realize long-acting anchoring of a bone defect part, so that the artificial microossification center is formed. The growth factor PDGF-BB is explosively released in the early stage to collect endogenous stem cells through a CXCR axis, calcium ions and zinc ions are released in a sequential long-acting mode to continuously play a'bone island 'role of promoting bone regeneration and vascular regeneration, and healing of femoral condyle defects is achieved within four weeks. A transcriptome sequencing result of a rat bone defect tissue verifies that the short fiber microsphere possibly plays a role in promoting osteogenesis and revascularization through MAPK / ERK and ERBB / ERK pathways, and can efficiently promote bone tissue mineralization and regeneration.

Devices, systems, and methods for revascularization of the myocardium are disclosed, such as an intravascular medical device for shunting and selectively regulating anatomical fluid flow. A tubular shunt is configured for deployment in a passageway between a first organ and a second adjacent organ and to bridge a first cavity in the first organ and a second cavity in the second organ. A stabilizer is configured to stabilize the tubular shunt in the passageway. A flow deflector extends from the tubular shunt and has a surface for deflecting flow in the second cavity.

The invention provides a bone organ scaffold and a manufacturing method thereof, and relates to the technical field of bone organ scaffolds. The bracket comprises a plurality of functional layers which are arranged in sequence; each functional layer comprises a plurality of through holes in the transverse direction; the through holes of different functional layers correspond to one another in the longitudinal direction to form a plurality of first channels penetrating through the bracket; each functional layer comprises an upper part and a lower part in the longitudinal direction; the lower half part is a solid matrix layer; the upper half part is a filling layer; the filling layer comprises a plurality of solid matrix strips which are uniformly distributed; a gap is reserved between every two adjacent solid matrix strips to form a second channel for connecting the periphery of the functional layer with the first channel. According to the scheme, rapid production and manufacturing can be carried out through a 3D biological printing technology, and the manufacturing period of the stent is shortened; the biomimetic mineralization and neovascularization coupled bone organ designed by the scheme can be implanted into a femoral head necrosis area in the early stage of collapse in combination with a medullary decompression technology, and sufficient mechanical support and a sufficient blood supply reconstruction and bone repair environment are provided.

The application provides a multifunctional adsorbent and a preparation method and application thereof, and the multifunctional adsorbent comprises a carrier and a functional layer arranged on the outer layer of the carrier; the carrier is polystyrene-epoxy resin; the functional layer is composed of a first grafting layer and a second grafting layer, the first grafting layer is formed by reacting tryptophan with the epoxy group of the carrier, and the second grafting layer is formed by reacting polyacrylic acid with the acryloyl group introduced on the carrier. The multifunctional adsorbent can simultaneously adsorb FIB, LDL-C and key inflammatory factors in blood, so as to reduce the high coagulation state of blood, improve lipid metabolism and inhibit excessive inflammatory reaction, thereby providing an effective scheme which can significantly improve the clinical prognosis for CLTI patients who cannot accept blood revascularization.

The application provides a multifunctional apical area blood leading device applied to a dental pulp blood supply reconstruction operation and relates to the technical field of the dental pulp blood supply reconstruction.The multifunctional apical area blood leading device applied to the dental pulp blood supply reconstruction operation comprises a holding mechanism, a fixing mechanism is fixedly arranged below the holding mechanism, a main body mechanism is arranged through the holding mechanism and the fixing mechanism, the main body mechanism is fixed between the holding mechanism and the fixing mechanism, a rubber stopper is arranged on the surface of the main body mechanism, the main body mechanism comprises a through rod, a cutting blade is arranged at the bottom end of the through rod, a blood leading head is fixedly arranged at the bottom end of the cutting blade, the blood leading head comprises a connecting disc, a plurality of pricking heads are fixedly arranged at the bottom end of the connecting disc, and the plurality of pricking heads are made of stainless steel.The device can brush the apical tissue during rotation, realizes rapid and sufficient blood leading, and is more convenient to operate.

The invention provides a traditional Chinese medicine composition for acute ischemic stroke and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises astragalus membranaceus, coptis chinensis, rhizoma acori graminei, radix paeoniae rubra, lumbricus and lalang grass rhizome. The traditional Chinese medicine raw materials in the traditional Chinese medicine composition are scientific in compatibility, and have the effects of tonifying qi, detoxifying, reducing phlegm, inducing resuscitation, activating blood and inducing diuresis. Pharmacodynamic experiments prove that the traditional Chinese medicine composition can remarkably reduce the cerebral infarction volume and effectively protect the cerebral vascular structure, is high in safety and does not have common risks of bleeding and liver injury of western medicines. The traditional Chinese medicine composition is particularly suitable for being used in combination with western medicine revascularization treatment, and a safe and effective Chinese and western medicine combined treatment scheme is provided for the acute stage of cerebral apoplexy.

The invention provides an angiogenesis promoting wound repair material Ru / pCeO2 based on defective CeO2 as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The wound repair material Ru / pCeO2 based on defect type CeO2 is prepared, rich surface oxygen defects can be constructed by adjusting the crystal growth environment in the hydrothermal process, and photo-induced electron recombination is reduced; and meanwhile, Ru clusters are loaded on the surface of Ru / pCeO2, so that an energy band structure can be optimized, the performance of photocatalytic reduction of CO2 into CO is effectively improved, and a material foundation is laid for subsequent wound treatment. According to the invention, long-term, local and safe-concentration controllable release of CO gas is expected to be realized, and wound blood vessel repair is specifically promoted. Meanwhile, the whole body exposure risk and the oxygen deficit hidden danger of a traditional CO inhalation therapy are avoided, and a safer and more effective solution is provided for wound repair and revascularization treatment.

Devices, systems, and methods for revascularization of the myocardium are disclosed, such as an intravascular medical device for shunting and selectively regulating anatomical fluid flow. A tubular shunt is configured for deployment in a passageway between a first organ and a second adjacent organ and to bridge a first cavity in the first organ and a second cavity in the second organ. A stabilizer is configured to stabilize the tubular shunt in the passageway. A flow deflector extends from the tubular shunt and has a surface for deflecting flow in the second cavity.

The invention belongs to the technical field of biological medicines, and discloses a hydrogel antibacterial dressing containing dragon's blood oil and a preparation method thereof. The hydrogel is characterized by comprising a three-dimensional hydrogel matrix formed by co-crosslinking methylacryloylated hyaluronic acid and gelatin, an in-situ compounded PEDOT: PSS / sodium carboxymethyl cellulose conductive nanofiber network, and dragon's blood oil microcapsules which are self-assembled and coated layer by layer by sodium alginate-chitosan and are modified by PEG (Polyethylene Glycol). Through the design, the dressing has stable conductivity (1.2-2.5 S / m), dual-phase drug release and excellent biocompatibility, synergistically promotes cell migration and microenvironment regulation and control under a low-intensity direct-current electric field, and significantly accelerates reepithelization and revascularization of diabetic wounds. According to the invention, the limitation of a dressing with a single function is overcome, the space-time coupling of a physical stimulation signal and a biochemical regulation signal is realized on a material architecture level, and an efficient, safe and clinically convertible novel treatment scheme is provided for the refractory wound of diabetes mellitus.

The subject invention pertains to a novel method for treating Peripheral Arterial Disease (PAD) by leveraging the angiogenic potential of type 2 cytokines IL-4 and IL-13 to enhance the efficacy of induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) and induced endothelial cells derived from fibroblasts (iECs). This present invention aims at enhancing the muscle regeneration and revascularization for obese and diabetes individuals.

Devices, systems, and methods for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium are disclosed. Devices and methods include a method for causing retrograde oxygenated blood flow in at least a portion of the venous system of the myocardium, the method comprising: implanting a variable occluder in a coronary sinus region proximate a left atrium, wherein the variable occluder is configured to gradually increase a level of blood flow restriction over a period of days to enable a venous system of the myocardium to compensate for increased pressure caused by the gradual increase in the level of blood flow restriction; and following venous system compensation, shunting oxygenated blood flow into the coronary sinus to cause retrograde flow of oxygenated blood in at least a portion of the venous system of the myocardium to thereby enable revascularization of the myocardium.

According to the surface-modified anti-angiogenesis nano assembly and the preparation method thereof, the KK polypeptide is modified and grafted at the tail end of the anti-VEGF functional polypeptide, so that the electropositivity of the anti-VEGF functional polypeptide is enhanced to promote penetration, and meanwhile, the anti-VEGF functional polypeptide is self-assembled with copper ions to form stable nano particles; the nano-particles can effectively treat inflammatory reaction and revascularization problems after eye alkali burn. A penetrating peptide and an ROS scavenger TEMPO are further inoculated through an amidation reaction, and activation of an NF-kappa B signal channel is inhibited by regulating and controlling the ROS level, so that the immune cell state is regulated, oxidative stress is eliminated, and tissue damage is relieved. The method disclosed by the invention is simple and convenient to operate, mild in experimental condition and relatively high in ocular surface retention time and cell entry efficiency, and the obtained nano-particles can be used for treating the eye alkali burn, have a remarkable curative effect, are particularly suitable for combined treatment of anti-angiogenesis and anti-oxidative stress, and have wide clinical application potential.

The application discloses a brain perfusion parameter prediction blood vessel recanalization grade method and system, and belongs to the technical field of medical image processing. The method comprises the following steps: acquiring a preoperative CTP parameter map and a CTA maximum density projection reconstruction map of an acute large blood vessel occlusive stroke patient and a dynamic scanning sequence of CTP scanning; extracting functional perfusion features from a CTP channel and morphological structure features from a CTA channel through a multi-modal feature fusion network; extracting a collateral compensation vector based on a CTP dynamic sequence through a pre-constructed collateral circulation embedding module; modeling six discrete grades into an ordered category by using an mTICI hierarchical ordered regression prediction head of a cumulative link model; and modulating a prediction output by the collateral compensation vector through an attention gate mechanism, and outputting an mTICI grade prediction probability distribution. The application realizes preoperative prospective prediction of an mTICI grade after mechanical thrombectomy.