386 results about "Three dimensional matrix" patented technology

The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits fluidly connecting the at least one reservoir with the plurality of chambers; and at least one pump fluidly connected through the plurality of conduits with the at least one reservoir and with the plurality of chambers to pump cell support medium therethrough; wherein each individual chamber of the plurality of chambers includes at least one three-dimensional matrix comprising polyethylene terephthalate, a plurality of channels carrying the cell support medium and having the matrix positioned in fluid communication therebetween, and at least two openings into each the channel, wherein a first the opening is in fluid connection with the pump and a second the opening is in fluid connection with the reservoir.

The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.

A non-woven polymeric matrix for separating leukocytes from a blood sample includes a non-woven three dimensional matrix formed from polymeric fibers having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size in the range of from about 10 μm to about 250 μm, and a plurality of connections between the plurality of fibers. The matrix is configured so as to remove at least about 98% of leukocytes from at least one unit of packed red blood cells. Methods of making and using the matrix are also provided.

The present invention relates to compositions and methods of preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a bioactive ceramic component and a polymer component. The matrix provides an osteoconductive and osteoinductive scaffold supporting osteogenesis and thereby facilitates bone repair.

Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.

A spinal implant in one embodiment includes an implant for insertion between two opposite spaced vertebrae of a spine, comprising a body having a substantially rectangular cross section and comprising a toothed top retaining member, a toothed bottom retaining member, and a peripheral surface; a three-dimensional matrix structure formed in the body and on the peripheral surface as support; and a plurality of holes formed through at least one of three directions of the three-dimensional matrix structure.

A bio-artificial organ system is provided comprising a wall surrounding a space which has a solid support for cell cultivation. The space includes a there dimensional matrix in the form of a highly porous sheet or mat and including a physiologically acceptable network of fibers or an open-pore foam structure; hydrophobic hollow fibers permeable to gaseous oxygen or gaseous carbon dioxide evenly distributed through the three dimensional matrix material and arranged in parallel running from one end of the matrix material to the other end of the matrix material. Cells obtained from organs are present in the extra fiber space for culture wherein the cells are provided with sufficient oxygenation and are maintained as small aggregates with three dimensional attachment.

In a method and user interface for the presentation of multiple image data sets within the scope of a comparative evaluation, a determination is made of at least three organization parameters that describe a sorting of images within an image data set and/or across image data sets, at least one organization parameter is associated with at least one dimension of a three-dimensional matrix, which one dimension is associated with a spatial direction, the images of the image data sets are arranged in the three-dimensional matrix according to the sorting, using the organization parameters and the dimensions, and at least a portion of the images is shown on a presentation device according to their arrangement in the three-dimensional matrix and the spatial directions.

A spinal implant in one embodiment includes an implant for insertion between two opposite spaced vertebrae of a spine, comprising an upper section having a substantially rectangular cross section and comprising a toothed top retaining member and a peripheral surface; a lower section having a substantially rectangular cross section and comprising a toothed bottom retaining member and a peripheral surface; an intermediate padding member for fastening the upper section and the lower section together; two three-dimensional matrix structures formed in the upper section and the lower section respectively and on the peripheral surfaces of the upper section and the lower section respectively as support; and a plurality of holes formed through at least one of three directions of each of the three-dimensional matrix structures.

Methods for wound healing or tissue regeneration by means of cell and tissue engineering, including using three-dimensional matrices with cells therein. A three-dimensional matrix, optionally containing cells such as fibroblasts, is inserted Into the wound of a subject. An anti-inflammatory factor may also be used to reduce or suppress the immune response. The wound may be covered to limit exposure to gaseous oxygen, for example, using a membrane. An anticoagulant may also be applied. In addition, cells, such as fibroblasts or stem cells, when cultured within a three-dimensional matrix, under certain conditions, can be induced to form non-fibroblast multipotent cells. When stem cells are cultured in the three-dimensional matrix, at least some of the stem cells remain as stem cells and do not differentiate. Kits for promoting the control of cells within three-dimensional matrices are also disclosed.

The invention discloses a human body skeleton motion sequence behavior identification method. The method includes acquiring human body skeleton node coordinates; serially connecting the nodes corresponding to the limbs of the human body skeleton to form the motion characteristic expressions of the limbs and the trunk; serially connecting the motion characteristic expressions of the limbs and the trunk to form the vector expression of the human body skeleton; arranging the vector expressions corresponding to the frames in the human body skeleton motion sequence according to time sequence to obtain a three dimensional matrix; performing the normalization of the values in the three-dimensional matrix and the normalization of the dimensions to obtain the image expression corresponding to the human body skeleton motion sequence; adaptively extracting the texture characteristic expression in the image expression by means of a convolutional neural network; and performing behavior class determination based on the texture characteristic expression and determining the behavior class of the human body skeleton motion sequence by voting. The method can accurately identify people's behaviors based on the human body skeleton motion sequence without the need for complex data preprocessing.

A braided, rather than woven, three-dimensional matrix has been developed to provide mechanical support in breast reconstruction or a mastopexy procedure. The braided three-dimensional matrix may be used to assist in hernia repair procedures. The matrix is a supple, strong, and flexible material, that can increase 50% to 100% in size when stretched along the vertical plane, but only extends by about 10% to 20% in length when stretched along the horizontal plane. Although the matrix is degradable, it provides sufficient mechanical and structural support for six to twelve months following implantation to allow for repair or growth of the breast tissue or the abdominal wall. The matrix is formed of three-dimensional braided multifilament polymeric fibers plied to create yarn bundles, and wherein the matrix comprises an inter-connected, open pore structure that enables even and random distribution and in-growth of cells.

A building façade system adapted to be installed onto an exposed surface of a building and provide a substrate for installation of façade elements (e.g., stone, stucco and the like). The system preferably provides a corrosion-resistant structure adapted to withstand extended environmental exposure. In general, the system includes a highly porous three dimensional matrix filamentous polymeric mat and a fiberglass mesh layer associated therewith. Collectively, the polymeric mat and fiberglass mesh layer are adapted to be installed onto an exposed building wall and provide a substrate onto which desired façade elements may be installed.

The invention discloses a non-local image denoising method based on low rank restoration. The method comprises the steps of (1) collecting an image, (2) carrying out gray transformation on the collected image, (3) establishing a three-dimensional similarity matrix through the global search of a similar pixel block for the image which is subjected to gray transformation, then carrying out hard threshold filtering on the discrete cosine transform and Hadamard transform coefficients of the three-dimensional matrix is carried out, obtaining the initial estimation of the similar pixel block with the removal of partial noise, and improving the matching accuracy of the similar pixel block with low rank restoration denoising while removing a large part of noise, and (4) with transform domain filtering as prior knowledge, searching a similar pixel block in a search area for an initially denoised reference pixel block, then forming the similarity matrix by using a similarity block corresponding to an original image, carrying out low rank matrix decomposition on the similarity matrix, effectively separating noise and a signal, and obtaining a final denoised image. The method has the advantages of a simple and fast algorithm, a high signal-to-noise ratio and good consistency and is especially suitable for the requirements of high quality noise reduction of large-scale images.

The invention provides a PET (Polyethylene terephthalate) three-dimensional image reconstruction method and device. The method comprises the following steps: initializing a three-dimensional image to cause the pixel value of a pixel, which is positioned on a three-dimensional matrix in a first coordinate system (X, Y, Z), of the initialized three-dimensional image to be f1(x,y,z); selecting one line-of-response subset from a plurality of line-of-response subsets obtained from a detector; successively selecting line-of-response groups from the selected line-of-response subset, and independently carrying out preset operation to each selected line-of-response group, wherein the preset operation comprises the step of obtaining the pixel value g1(s,t,z) of each pixel of the first pixel group which is positioned in a second coordinate system (S,T,Z) and corresponds to the selected according to the pixel value f1(x,y,z) of the pixel in the first coordinate system (X, Y, Z), and the pixels of the first pixel group are positioned on a plurality of lines of response corresponding to the selected line-of-response group. Three-dimensional image reconstruction efficiency can be improved.

A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.

A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.