388 results about "Three dimensional matrix" patented technology

The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.

Devices for improving the capturing and utilization of high-energy electromagnetic radiation, for example, x-rays, gamma rays, and neutrons, for use in physical, medical, and industrial analysis and control applications are disclosed. The devices include optics having a plurality of optical crystals, for example, doubly-curved silicon or germanium crystals, arranged to optimize the capture and redirection of divergent radiation via Bragg diffraction. In one aspect, a plurality of optic crystals having varying atomic diffraction plane orientations are used to capture and focus divergent x-rays upon a target. In another aspect, a two- or three-dimensional matrix of crystals is positioned relative to an x-ray source to capture and focus divergent x-rays in three dimensions.

An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits fluidly connecting the at least one reservoir with the plurality of chambers; and at least one pump fluidly connected through the plurality of conduits with the at least one reservoir and with the plurality of chambers to pump cell support medium therethrough; wherein each individual chamber of the plurality of chambers includes at least one three-dimensional matrix comprising polyethylene terephthalate, a plurality of channels carrying the cell support medium and having the matrix positioned in fluid communication therebetween, and at least two openings into each the channel, wherein a first the opening is in fluid connection with the pump and a second the opening is in fluid connection with the reservoir.

The present invention relates to fiber compositions comprising gels or hydrogels. The invention further relates to the composition of a gel or hydrogel loaded biodegradable fiber and methods of fabricating such fibers. The present invention further provides tissue engineering and drug-delivery compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The invention also relates to methods of manipulating the rate of therapeutic agent release by changing both the biodegradable polymer properties as well as altering the properties of the incorporated gel or hydrogel.

A non-woven polymeric matrix for separating leukocytes from a blood sample includes a non-woven three dimensional matrix formed from polymeric fibers having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size in the range of from about 10 μm to about 250 μm, and a plurality of connections between the plurality of fibers. The matrix is configured so as to remove at least about 98% of leukocytes from at least one unit of packed red blood cells. Methods of making and using the matrix are also provided.

The present invention relates to compositions and methods of preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a bioactive ceramic component and a polymer component. The matrix provides an osteoconductive and osteoinductive scaffold supporting osteogenesis and thereby facilitates bone repair.

Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.

A spinal implant in one embodiment includes an implant for insertion between two opposite spaced vertebrae of a spine, comprising a body having a substantially rectangular cross section and comprising a toothed top retaining member, a toothed bottom retaining member, and a peripheral surface; a three-dimensional matrix structure formed in the body and on the peripheral surface as support; and a plurality of holes formed through at least one of three directions of the three-dimensional matrix structure.

The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers seeded with isolated differentiable human mesenchymal cells, wherein the matrix forms a supporting scaffold for growing the isolated differentiable human mesenchymal cells, and wherein the differentiable human mesenchymal cells differentiate into a mature cell phenotype. The invention further provides methods of preparing the implantable nanofiber matrix scaffolding seeded with differentiable human mesenchymal cells for use in tissue engineering.

A bio-artificial organ system is provided comprising a wall surrounding a space which has a solid support for cell cultivation. The space includes a there dimensional matrix in the form of a highly porous sheet or mat and including a physiologically acceptable network of fibers or an open-pore foam structure; hydrophobic hollow fibers permeable to gaseous oxygen or gaseous carbon dioxide evenly distributed through the three dimensional matrix material and arranged in parallel running from one end of the matrix material to the other end of the matrix material. Cells obtained from organs are present in the extra fiber space for culture wherein the cells are provided with sufficient oxygenation and are maintained as small aggregates with three dimensional attachment.

In a method and user interface for the presentation of multiple image data sets within the scope of a comparative evaluation, a determination is made of at least three organization parameters that describe a sorting of images within an image data set and / or across image data sets, at least one organization parameter is associated with at least one dimension of a three-dimensional matrix, which one dimension is associated with a spatial direction, the images of the image data sets are arranged in the three-dimensional matrix according to the sorting, using the organization parameters and the dimensions, and at least a portion of the images is shown on a presentation device according to their arrangement in the three-dimensional matrix and the spatial directions.

An apparatus and method for a modular cell culture bioreactor comprises a plurality of chambers for cell culture; at least one reservoir containing a cell support medium; a plurality of conduits fluidly connecting the at least one reservoir with the plurality of chambers; and at least one pump fluidly connected through the plurality of conduits with the at least one reservoir and with the plurality of chambers to pump cell support medium therethrough; wherein each individual chamber of the plurality of chambers includes at least one three-dimensional matrix comprising polyethylene terephthalate, a plurality of channels carrying the cell support medium and having the matrix positioned in fluid communication therebetween, and at least two openings into each the channel, wherein a first the opening is in fluid connection with the pump and a second the opening is in fluid connection with the reservoir.

A structured porous metamaterial includes a three-dimensional matrix of at least one repeating base unit. The matrix is formed from an array of at least eight base units, each base unit including a platonic solid including at least one shaped void, wherein each base unit has void geometry tailored to provide a porosity of between 0.3 and 0.97, and to provide the metamaterial with a response that includes a Poisson's ratio of 0 to −0.5 when under tension and compression, or negative linear compression (NLC), negative area compression (NAC), zero linear compression (ZLC), or zero area compression (ZAC) behaviour when under pressure.

A spinal implant in one embodiment includes an implant for insertion between two opposite spaced vertebrae of a spine, comprising an upper section having a substantially rectangular cross section and comprising a toothed top retaining member and a peripheral surface; a lower section having a substantially rectangular cross section and comprising a toothed bottom retaining member and a peripheral surface; an intermediate padding member for fastening the upper section and the lower section together; two three-dimensional matrix structures formed in the upper section and the lower section respectively and on the peripheral surfaces of the upper section and the lower section respectively as support; and a plurality of holes formed through at least one of three directions of each of the three-dimensional matrix structures.

Methods for wound healing or tissue regeneration by means of cell and tissue engineering, including using three-dimensional matrices with cells therein. A three-dimensional matrix, optionally containing cells such as fibroblasts, is inserted Into the wound of a subject. An anti-inflammatory factor may also be used to reduce or suppress the immune response. The wound may be covered to limit exposure to gaseous oxygen, for example, using a membrane. An anticoagulant may also be applied. In addition, cells, such as fibroblasts or stem cells, when cultured within a three-dimensional matrix, under certain conditions, can be induced to form non-fibroblast multipotent cells. When stem cells are cultured in the three-dimensional matrix, at least some of the stem cells remain as stem cells and do not differentiate. Kits for promoting the control of cells within three-dimensional matrices are also disclosed.

A system for characterizing a spot weld including an acoustic probe that further includes a plurality of ultrasonic transducer elements arranged in a curved array, wherein the transducer elements are operative to generate ultrasonic signals and to receive reflections thereof; and a combination of materials for allowing the probe to conform to a contoured surface of the spot weld while enabling sound energy to be transferred directly into the spot weld under test conditions; a phased array excitation unit coupled to the array of transducer elements for ultrasonically exciting transducer elements; and a controller coupled to the phased array excitation unit for controlling the operation of the phased array unit, gathering and processing information from the ultrasonic transducers, and generating a two-dimensional, color coded image that characterizes the integrity of the spot weld.

A system and method for “pixelating” a three-dimensional circuit structure into a three-dimensional matrix of cubes that are located with respect to a coordinate system. The design step is typically performed on a conventional computer using computer aided design software that pixelates the proposed circuit structure into an array of uniformly sized cube. The fabrication process involves adding and subtracting bulk materials from the individual cubic positions within the pixelated representation of the circuit structure. Various existing and new techniques can be used to add or subtract bulk materials as the cubic positions within the matrix to construct the circuit structure.

The invention discloses a human body skeleton motion sequence behavior identification method. The method includes acquiring human body skeleton node coordinates; serially connecting the nodes corresponding to the limbs of the human body skeleton to form the motion characteristic expressions of the limbs and the trunk; serially connecting the motion characteristic expressions of the limbs and the trunk to form the vector expression of the human body skeleton; arranging the vector expressions corresponding to the frames in the human body skeleton motion sequence according to time sequence to obtain a three dimensional matrix; performing the normalization of the values in the three-dimensional matrix and the normalization of the dimensions to obtain the image expression corresponding to the human body skeleton motion sequence; adaptively extracting the texture characteristic expression in the image expression by means of a convolutional neural network; and performing behavior class determination based on the texture characteristic expression and determining the behavior class of the human body skeleton motion sequence by voting. The method can accurately identify people's behaviors based on the human body skeleton motion sequence without the need for complex data preprocessing.

A braided, rather than woven, three-dimensional matrix has been developed to provide mechanical support in breast reconstruction or a mastopexy procedure. The braided three-dimensional matrix may be used to assist in hernia repair procedures. The matrix is a supple, strong, and flexible material, that can increase 50% to 100% in size when stretched along the vertical plane, but only extends by about 10% to 20% in length when stretched along the horizontal plane. Although the matrix is degradable, it provides sufficient mechanical and structural support for six to twelve months following implantation to allow for repair or growth of the breast tissue or the abdominal wall. The matrix is formed of three-dimensional braided multifilament polymeric fibers plied to create yarn bundles, and wherein the matrix comprises an inter-connected, open pore structure that enables even and random distribution and in-growth of cells.

A building façade system adapted to be installed onto an exposed surface of a building and provide a substrate for installation of façade elements (e.g., stone, stucco and the like). The system preferably provides a corrosion-resistant structure adapted to withstand extended environmental exposure. In general, the system includes a highly porous three dimensional matrix filamentous polymeric mat and a fiberglass mesh layer associated therewith. Collectively, the polymeric mat and fiberglass mesh layer are adapted to be installed onto an exposed building wall and provide a substrate onto which desired façade elements may be installed.

The invention discloses a non-local image denoising method based on low rank restoration. The method comprises the steps of (1) collecting an image, (2) carrying out gray transformation on the collected image, (3) establishing a three-dimensional similarity matrix through the global search of a similar pixel block for the image which is subjected to gray transformation, then carrying out hard threshold filtering on the discrete cosine transform and Hadamard transform coefficients of the three-dimensional matrix is carried out, obtaining the initial estimation of the similar pixel block with the removal of partial noise, and improving the matching accuracy of the similar pixel block with low rank restoration denoising while removing a large part of noise, and (4) with transform domain filtering as prior knowledge, searching a similar pixel block in a search area for an initially denoised reference pixel block, then forming the similarity matrix by using a similarity block corresponding to an original image, carrying out low rank matrix decomposition on the similarity matrix, effectively separating noise and a signal, and obtaining a final denoised image. The method has the advantages of a simple and fast algorithm, a high signal-to-noise ratio and good consistency and is especially suitable for the requirements of high quality noise reduction of large-scale images.

Cell delivery matrices and methods for facilitating local delivery of adipose derived endothelial cells to a target tissue, body cavity, or joint are described. The cell delivery matrix may be a three-dimensional matrix scaffold comprising fibrin derived from the patient's own body. The cell delivery matrix may be biocompatible and semi-permeable. The cell delivery matrix used in the methods of the invention may be comprised of any degradable, bioabsorbable or non-degradable, biocompatible polymer. Regenerative therapies comprising implanting in the subject cell delivery matrices localizing adipose derived endothelial cells are described. The cell delivery matrices maintain the adipose derived endothelial cells at the target for a therapeutically effective amount of time. The adipose derived endothelial cells can be allogenic or syngenic to the subject. The endothelial cells may be delivered alone or in combination with other therapeutic agents.

The invention provides a PET (Polyethylene terephthalate) three-dimensional image reconstruction method and device. The method comprises the following steps: initializing a three-dimensional image to cause the pixel value of a pixel, which is positioned on a three-dimensional matrix in a first coordinate system (X, Y, Z), of the initialized three-dimensional image to be f1(x,y,z); selecting one line-of-response subset from a plurality of line-of-response subsets obtained from a detector; successively selecting line-of-response groups from the selected line-of-response subset, and independently carrying out preset operation to each selected line-of-response group, wherein the preset operation comprises the step of obtaining the pixel value g1(s,t,z) of each pixel of the first pixel group which is positioned in a second coordinate system (S,T,Z) and corresponds to the selected according to the pixel value f1(x,y,z) of the pixel in the first coordinate system (X, Y, Z), and the pixels of the first pixel group are positioned on a plurality of lines of response corresponding to the selected line-of-response group. Three-dimensional image reconstruction efficiency can be improved.

A tissue scaffold fabricated from bioinert fiber forms a rigid three-dimensional porous matrix having a bioinert composition. Porosity in the form of interconnected pore space is provided by the space between the bioinert fiber in the porous matrix. Strength of the porous matrix is provided by bioinert fiber fused and bonded into the rigid three-dimensional matrix having a specific pore size and pore size distribution. The tissue scaffold supports tissue in-growth to provide osteoconductivity as a tissue scaffold, used for the repair of damaged and / or diseased bone tissue.

A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and / or diseased bone tissue.

Disclosed is a process for the co-manufacture of the hydrofluoroolefins HFC-1225ye and HFC-1234yf. The process comprises contacting a blend of 1,1,1,2,3,3-hexafluoropropane and 1,1,1,2,3-pentafluoropropane at a temperature of from about 200° C. to about 500° C. with a catalyst, optionally in the presence of an inert gas. The catalyst includes, but is not limited to, aluminum fluoride; fluorided alumina; metals on aluminum fluoride; metals on fluorided alumina; oxides, fluorides, and oxyfluorides of magnesium, zinc and mixtures of magnesium and zinc and / or aluminum; lanthanum oxide and fluorided lanthanum oxide; chromium oxides, fluorided chromium oxides, and cubic chromium trifluoride; carbon, acid-washed carbon, activated carbon, three dimensional matrix carbonaceous materials; and metal compounds supported on carbon. The metal compounds are oxides, fluorides, and oxyfluorides of at least one metal selected from the group consisting of sodium, potassium, rubidium, cesium, yttrium, lanthanum, cerium, praseodymium, neodymium, samarium, chromium, iron, cobalt, rhodium, nickel, copper, zinc, and mixtures thereof. The product hydrofluoroolefins are separated from unreacted hydrofluorocarbons and hydrogen fluoride. In another embodiment, the unreacted hydrofluorocarbons optionally may be recirculated back through the process.

A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and / or diseased bone tissue.

The invention relates to a structured porous metamaterial. The structured porous metamaterial comprises a three-dimensional matrix of at least one repeating base unit, wherein the matrix is formed from an array of at least eight base units, each base unit comprises a platonic solid including at least one shaped void, each base unit has void geometry tailored to provide a porosity of between 0.3 and 0.97; or provide the metamaterial with a response comprising at least one of a Poisson's ratio of 0 to -0.5 when under tension and compression; or negative linear compression (NLC), negative area compression (NAC), zero linear compression (ZLC), or zero area compression (ZAC) behaviour when under pressure.