The invention discloses a method for determining subway station structure stressed situation in fire. The method is characterized in that diffusion of a cellular automata (AC)-air mass model is simulated, gas macroscopic diffusion is taken as multiple air masses in an equivalent manner, the cellular automata is allowed to generate a moving model of the air masses, the air mass characteristics are expressed as Qi (Vi0, xi, yi), the Gaussian model is referred to determine an influence radius D to distinguish concentration gradient diffusion Sd and free diffusion Sf, the strength distribution of the wind in the streets is determined, a boundary contacting condition is constructed, a simulated city environment is assumed, the model is used to simulate ammonia diffusion when the wind speed is equal to 0.75 m / s, and influences on diffusion can be studied when the wind enters the streets in different moments. The method includes determining the influence radius D, determining an air mass automata model, determining change amount of air mass moving speed changes, determining wind field distribution, determining the boundary contacting condition, and setting model establishing parameters to simulate. The method can be applied in gas diffusion distribution simulation with the wind in conditions of complex arrangement of the city streets.