The invention discloses an artificial synaptic device based on a photoelectric coupling memristor and a modulation method of the artificial synaptic device. The artificial synaptic device comprises an upper electrode, a lower electrode and a functional material layer, wherein the functional material layer is arranged between the upper electrode and the lower electrode, the upper electrode, the functional material layer and the lower electrode jointly form a sandwich structure, the functional material layer is made of a material having a photoelectric effect, the lower electrode is a transparent conductive electrode, an electrical signal is input through the upper electrode and the lower electrode, and an optical signal is input through the transparent conductive electrode. In the artificial synaptic device provided by the invention, light is introduced as a control signal of the other end except the electrical signal, two control ends of the artificial synapse device are expanded to three ends, the artificial synaptic device can generate resistance change under an external optical excitation signal by the additionally-arranged end, the artificial synaptic device can be configured to be in a plurality of resistance states correspondingly by selection and control of intensity, frequency and optical pulse time of the optical excitation signal, and various synaptic plasticity functions are correspondingly achieved.