32 results about "CLOCK" patented technology

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The invention relates to application of migratory locust rhythm gene Clock in regulation and control of eclosion rhythm. According to the method, dsRNA of the migratory locust rhythm gene Clock is injected into a migratory locust body cavity, the expression quantity of the migratory locust rhythm gene Clock is remarkably reduced, the circadian rhythm and daily rhythm of migratory locust are both changed by regulating synthesis of 20E, living work and rest formed by long-term coevolution of migratory locust and the external environment are disrupted, serious harm is caused to survival and reproduction of migratory locust, and the migratory locust is prevented from being damaged. And a new way is provided for pest control.

1. Name of the designed product: clock (twelve animals). 2. Use of the designed product: clock for timing. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

1. The name of the design product: clock sound box (C09). 2. The use of the design product: clock sound box. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl)oxy)acetamidolbenzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMALl interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

Provided herein are methods and compositions for an epigenetic clock comprising differentiation-independent methylation sites to asses biological age of a human subject.

The application discloses application of glutamine ethyl indole in promoting biological rhythm gene expression. The application also provides a recovery agent for biological rhythm gene expression, which comprises glutamine ethyl indole. The application further provides application of the recovery agent for biological rhythm gene expression in skin care products and cosmetics and the skin care products and cosmetics. The recovery agent for biological rhythm gene expression of the application comprises glutamine ethyl indole, can restore the expression of CLOCK gene and Per3 gene to a normal stable level, helps to restore a normal cycle of rhythm, and provides a new skin care idea for biological rhythm cosmetics / skin care products.

The invention discloses a dynamic dimming method of an aircraft rhythm lighting system for adjusting human body time difference. In a cross-time-zone flight scene, the airplane dimming control system drives and controls the LED lighting equipment to be adjusted to a lighting state suitable for helping cross-time-zone rhythm adjustment of a human body according to ambient light feature information, flight time and time zone information and the internal integrated rhythm lighting dimming method. The rhythm illumination dimming algorithm comprises the following steps: dividing a flight process into N time periods according to take-off and landing time zone information of an aircraft, reasonably controlling an illumination system in a passenger cabin of the aircraft, adjusting the dynamic change of illumination intensity and light color according to rules in each time period, and helping passengers to gradually adjust the self circadian rhythm period to be synchronous with a destination solar clock, therefore, the trouble caused by time difference is reduced. The method is mainly used for adjusting the lighting environment in the passenger cabin of the aircraft during cross-time-zone long-endurance flight, and helping the human body adjust the circadian rhythm to resist the time difference syndrome.

The utility model provides a circulating timing reminder, and relates to the technical field of timers. The circulating timing reminder comprises a circulating control module, a timing module, a time setting module, a display module, a button module, a prompting module and a power supply module, wherein the circulation control module and the time setting module are electrically connected with the timing module; the display module is electrically connected with the timing module and the time setting module; the button module is electrically connected with the time setting module and the circulation control module; the prompting module is electrically connected with the timing module and the time setting module; the power supply module is electrically connected with all the modules. Wherein the cycle timing reminder provides cycle clock pulses for the timing module through the cycle control module, multiple sets of timing can be set at a time, and timing setting operation is simpler and more convenient.

The invention provides a mutual inductor verification master-slave clock error correction method, which comprises the following steps of: analyzing a specific reason for generating a deviation between a master clock and a slave clock in a mutual inductor verification system, and completing mathematical modeling of the error between the master clock and the slave clock according to the reason for the error; obtaining an initial deviation between the master clock and the slave clock of the mutual inductor; on the basis, the error of the master clock and the slave clock is corrected by using a Kalman filtering and RBF neural network adaptive control (RBF-PID) method, so that the deviation of the master clock and the slave clock is reduced, and the verification result of the mutual inductor is more accurate. Example analysis shows that the Kalman filtering has good filtering performance, and the RBF-PID algorithm has good adaptability and high convergence speed. An experiment and simulation combined example verifies that the method has good convergence precision and is suitable for actual production in the power industry.

The disclosure relates to methods for disrupting the function of upstream open reading frames (uORFs) in the 5' untranslated regions (UTRs) of plant clock regulator genes by introducing or selecting mutations, for example, using a gene editing construct, such as CRISPR / Cas (including Cas9, Cas12, MAD7, or SHARC™), which contains a polynucleotide encoding a Cas enzyme and at least one guide RNA targeting a uORF sequence in a plant. These guide RNAs specifically target uORFs in 5'UTRs associated with main open reading frames (ORFs) encoding polypeptides that are homologous to, or share at least 30%–100% identity with sequences set forth specified SEQ ID Nos disclosed therein. The disclosure also covers polypeptides (uPEPs) encoded by uORFs within sequences set forth in additional specified SEQ ID NOs or their homologous nucleotide sequences.

The invention provides a circadian rhythm evaluation method and system oriented to cardiovascular states, and belongs to the field of transcriptional gene analysis, and the method comprises the steps: obtaining transcriptome data at a single time point; gene expression data are positioned and extracted from the transcriptome data through a preset rhythm homeostasis gene module, and the rhythm homeostasis gene module is constructed through a weighted gene co-expression network analysis algorithm; and calculating the collaboration, the volatility and the network concentration degree of the gene expression data based on a dynamic network biomarker algorithm, and determining the circadian rhythm disorder index of the to-be-evaluated user according to the collaboration, the volatility and the network concentration degree. According to the method, collaborative expression characteristics are systematically captured by using a rhythm homeostasis gene module, dependence on a small number of core clock gene signals is avoided, and quantitative calculation is carried out on the collaboration, volatility and network concentration ratio of gene expression data in the module based on a dynamic network biomarker algorithm; and an objective and quantifiable molecular evaluation index is provided for an individual rhythm state.

The invention discloses an ancient clock inscription and texture point cloud projection analysis method based on a three-dimensional geometric model, and relates to the technical field of cultural heritage digitization, and the method comprises the following steps: S1, photogrammetry and point cloud reconstruction: obtaining multi-view image data of an ancient clock, and reconstructing a three-dimensional point cloud of the ancient clock based on a photogrammetry method; s2, geometric model construction: establishing a clock body geometric model based on the S-shaped function contour and rotational symmetry; s3, parameter fitting: fitting the clock body geometric model by using the three-dimensional point cloud of the ancient clock by adopting a Gauss-Helmert least square method so as to estimate the optimal parameters of the clock body geometric model; s4, performing regular gridding and projection; and S5, image enhancement and recognition. The ancient clock inscription and texture point cloud projection analysis method based on the three-dimensional geometric model can realize low-cost, high-precision and lossless digital identification.

The application discloses a yellow-feathered broiler feed conversion rate related CLOCK gene SNP molecular marker and application thereof, and belongs to the technical field of animal genetics and breeding and molecular biology. The SNP molecular marker polymorphism is G / A, is located at the 5903440th base of a chicken 27th chromosome CLOCK gene, and has an RS number of rs315082113. The SNP molecular marker polymorphism provided by the application is significantly related to a chicken feed conversion rate character, can be applied to selecting a chicken population with a low feed conversion rate character, improves the efficiency of a broiler industry, provides convenience and technical support for rapid breeding of a low feed conversion rate broiler, can effectively reduce feed costs in a production process, and improves economic benefits and competition of enterprises.

1. Name of the product in this design: Clock (99324). 2. Purpose of this design: for use in clocks and watches. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

1. Name of the designed product: clock sound (jellyfish). 2. Use of the designed product: sound equipment with timing reminder function. 3. Design points of the designed product: in shape. 4. Picture or photo that best shows the design points: perspective view.

The invention relates to the technical field of chimes, in particular to a harmonic therapeutic healing health-care chime which comprises a suspension bracket, a chime group composed of a plurality of U-shaped sound tubes is suspended on the suspension bracket, openings of the U-shaped sound tubes are arranged downwards, and musical scales of the chime group adopt musical sound sequence combination with the fundamental frequency of 380Hz-500Hz. The chime provided by the invention adopts a pure yellow clock 432Hz fundamental frequency musical sound sequence combination, the smooth rhythm and penetrating power of the chime can effectively soothe the body, relax nerves and promote cell and body repair, and ultrasonic waves, infrasonic waves, second-order harmonic waves and third-order harmonic waves generated during playing can deconstruct and kill microorganisms and viruses, so that the therapeutic and healing value of expelling evil and eliminating diseases is fully exerted, and the chime has a good application prospect. The problem that a traditional chime is difficult to accurately adapt to the modern health care acoustic therapy and healing requirements is solved.

The present invention provides agents and other devices that can advance the phase of the circadian rhythm. [Solution] The body clock regulator contains bergamot oil, geranium oil, and cedarwood. It contains at least one of Virginia oil, citral, and β-caryophyllene. It contains an active ingredient that advances the phase of the expression rhythm of clock genes.

1. The name of the design product: clock sound box (DY66). 2. The use of the design product: for playing music. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

1. Name of the product in this design: Clock Sound (SCB-201). 2. Purpose of this design: This design is used for clocks and speakers. 3. The key design features of this product are its overall shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention provides a method for generating a biological clock containing a DNA methylation map applicable to at least two different sample types, the method comprising: (i) providing a first set of DNA methylation maps generated from at least two different sample types from multiple subjects; (ii) generating a composite DNA methylation map from the first set of DNA methylation maps, wherein the composite DNA methylation map contains methylation sites having a matching state in the different sample types; and (iii) generating a biological clock using the composite DNA methylation map with a reference DNA methylation map from one of the at least two sample types.

The application discloses a kind of ancient clock inscription and texture point cloud projection analysis method based on three-dimensional geometric model, it is related to cultural heritage digitization technical field, including the following steps: S1, photogrammetry and point cloud reconstruction: obtain the multi-view image data of ancient clock, and reconstruct the three-dimensional point cloud of ancient clock based on photogrammetry method;S2, geometric model construction: establish clock body geometric model based on S function profile and rotational symmetry;S3, parameter fitting: using Gauss-Helmert least square method, the three-dimensional point cloud of ancient clock is used to fit clock body geometric model to estimate the optimal parameter of clock body geometric model;S4, regular gridding and projection;S5, image enhancement and identification.The ancient clock inscription and texture point cloud projection analysis method based on three-dimensional geometric model can realize low-cost, high-precision, non-destructive digitization identification.

The invention discloses a rapid detection kit for circadian rhythm imbalance of zebra fish cells. The rapid detection kit comprises a juvenile zebra fish splitting / RNA (Ribonucleic Acid) binding plate, a sealing plate membrane, a cell splitting solution, washing buffer solutions I and II, a DNase I digestive solution, a reaction buffer solution, a nuclease-free eluent, a 5x rapid reverse transcription premixed solution, a 2x SYBR Green qPCR (Polymerase Chain Reaction) premixed solution, a set of specific primer premixed solution and nuclease-free water. The invention also discloses an application of the kit. The invention also discloses a method for screening a compound or substance for regulating and controlling diurnal rhythm imbalance of zebrafish cells by using the kit. The invention can quickly, accurately and conveniently detect the expression of a plurality of core clock genes, is suitable for a kit in a high-throughput screening mode, and has urgent practical significance on environmental pollutant screening, clock regulation drug discovery and basic rhythm research.

The invention relates to the technical field of biological active substance extraction and health food, in particular to green brick tea theabrownin, a preparation method of the green brick tea theabrownin and application of the green brick tea theabrownin to preparation of products for improving circadian rhythm disorder and depression-like behaviors. The green brick tea theabrownin is obtained. The extracted green brick tea theabrownin has an improvement effect on the depressive mood behavior of a mouse with circadian rhythm disorder; the metabolism and immune injury of mice with circadian rhythm disorder can be relieved by improving lipid metabolism and inhibiting inflammatory response; multi-organ pathological injury of the mice with circadian rhythm disorder can be protected, so that edema of colonic mucosa of the mice is reduced, fatty degeneration of liver is relieved, and hippocampal neuron injury is relieved; and the rhythm disorder of the central clock gene of the circadian rhythm disorder mouse can be repaired by adjusting the expression of the central clock gene.