38 results about "CLOCK" patented technology

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

The invention relates to application of migratory locust rhythm gene Clock in regulation and control of eclosion rhythm. According to the method, dsRNA of the migratory locust rhythm gene Clock is injected into a migratory locust body cavity, the expression quantity of the migratory locust rhythm gene Clock is remarkably reduced, the circadian rhythm and daily rhythm of migratory locust are both changed by regulating synthesis of 20E, living work and rest formed by long-term coevolution of migratory locust and the external environment are disrupted, serious harm is caused to survival and reproduction of migratory locust, and the migratory locust is prevented from being damaged. And a new way is provided for pest control.

1. Name of the designed product: clock (twelve animals). 2. Use of the designed product: clock for timing. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view.

1. The name of the design product: clock sound box (C09). 2. The use of the design product: clock sound box. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl)oxy)acetamidolbenzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and / or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMALl interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and / or prevention of disorders associated with the circadian rhythm.

Provided herein are methods and compositions for an epigenetic clock comprising differentiation-independent methylation sites to asses biological age of a human subject.

The application discloses application of glutamine ethyl indole in promoting biological rhythm gene expression. The application also provides a recovery agent for biological rhythm gene expression, which comprises glutamine ethyl indole. The application further provides application of the recovery agent for biological rhythm gene expression in skin care products and cosmetics and the skin care products and cosmetics. The recovery agent for biological rhythm gene expression of the application comprises glutamine ethyl indole, can restore the expression of CLOCK gene and Per3 gene to a normal stable level, helps to restore a normal cycle of rhythm, and provides a new skin care idea for biological rhythm cosmetics / skin care products.

This item is a clock that has a bat ring arranged at the top and is used by hanging a chain passed through this bat ring around the neck, etc.

The invention discloses a dynamic dimming method of an aircraft rhythm lighting system for adjusting human body time difference. In a cross-time-zone flight scene, the airplane dimming control system drives and controls the LED lighting equipment to be adjusted to a lighting state suitable for helping cross-time-zone rhythm adjustment of a human body according to ambient light feature information, flight time and time zone information and the internal integrated rhythm lighting dimming method. The rhythm illumination dimming algorithm comprises the following steps: dividing a flight process into N time periods according to take-off and landing time zone information of an aircraft, reasonably controlling an illumination system in a passenger cabin of the aircraft, adjusting the dynamic change of illumination intensity and light color according to rules in each time period, and helping passengers to gradually adjust the self circadian rhythm period to be synchronous with a destination solar clock, therefore, the trouble caused by time difference is reduced. The method is mainly used for adjusting the lighting environment in the passenger cabin of the aircraft during cross-time-zone long-endurance flight, and helping the human body adjust the circadian rhythm to resist the time difference syndrome.

Circadian rhythms control the diurnal nature of many physiological, metabolic and immune processes. The inventors hypothesized that age-related impairments in circadian rhythms are associated with high susceptibility to bacterial respiratory tract infections. The diurnal control of Streptococcus pneumoniae infection is impaired in elderly mice. A lung circadian transcriptome analysis revealed that aging alters the daily oscillations in the expression of a specific set of genes and that some pathways that are rhythmic in young-adult mice are nonrhythmic or time-shifted in elderly mice. In particular, the circadian expression of the clock components Rev-erb-α, and Rev-erb-β to a lesser extent, altogether with apelin / apelin receptor were altered in elderly mice compared to young mice. In young mice, the inventors discovered that novel interaction between Rev-erb and the apelinergic axis controls host defenses against S. pneumoniae via alveolar macrophages. Pharmacological repression of Rev-erb-α and / or Rev- erb-β in elderly mice resulted in greater resistance to pneumococcal infection. Thus, the present invention relates to the use of Rev-erb antagonists for the treatment of lung infections.

The utility model provides a circulating timing reminder, and relates to the technical field of timers. The circulating timing reminder comprises a circulating control module, a timing module, a time setting module, a display module, a button module, a prompting module and a power supply module, wherein the circulation control module and the time setting module are electrically connected with the timing module; the display module is electrically connected with the timing module and the time setting module; the button module is electrically connected with the time setting module and the circulation control module; the prompting module is electrically connected with the timing module and the time setting module; the power supply module is electrically connected with all the modules. Wherein the cycle timing reminder provides cycle clock pulses for the timing module through the cycle control module, multiple sets of timing can be set at a time, and timing setting operation is simpler and more convenient.

The invention provides a mutual inductor verification master-slave clock error correction method, which comprises the following steps of: analyzing a specific reason for generating a deviation between a master clock and a slave clock in a mutual inductor verification system, and completing mathematical modeling of the error between the master clock and the slave clock according to the reason for the error; obtaining an initial deviation between the master clock and the slave clock of the mutual inductor; on the basis, the error of the master clock and the slave clock is corrected by using a Kalman filtering and RBF neural network adaptive control (RBF-PID) method, so that the deviation of the master clock and the slave clock is reduced, and the verification result of the mutual inductor is more accurate. Example analysis shows that the Kalman filtering has good filtering performance, and the RBF-PID algorithm has good adaptability and high convergence speed. An experiment and simulation combined example verifies that the method has good convergence precision and is suitable for actual production in the power industry.

The utility model relates to the field of clocks, in particular to a clock with a rotary ornament and pointers operated separately, which comprises a clock shell, a travel time pointer, a first ornament, a second ornament and a connecting mechanism. Wherein the travel time pointers are arranged on the front surface of the clock shell, and the travel time pointers are controlled by a first movement arranged on the back surface of the clock shell. When the travel time pointer is used, the first movement independently controls the travel time pointer, the first decoration and the second decoration for decoration are independently controlled by the second movement, the first movement and the second movement are respectively provided with an independent power supply, and the first decoration and the second decoration are separated from the travel time pointer. Therefore, the rotation of the first ornament and the second ornament does not consume the power supply of the first movement corresponding to the travel time pointer, the consumption of electric energy is avoided, the first ornament and the second ornament do not influence the stability of a travel time system, the dynamic sense of the first ornament and the second ornament can be ensured, and the clock has good dynamic sense and ornamental value.

The disclosure relates to methods for disrupting the function of upstream open reading frames (uORFs) in the 5' untranslated regions (UTRs) of plant clock regulator genes by introducing or selecting mutations, for example, using a gene editing construct, such as CRISPR / Cas (including Cas9, Cas12, MAD7, or SHARC™), which contains a polynucleotide encoding a Cas enzyme and at least one guide RNA targeting a uORF sequence in a plant. These guide RNAs specifically target uORFs in 5'UTRs associated with main open reading frames (ORFs) encoding polypeptides that are homologous to, or share at least 30%–100% identity with sequences set forth specified SEQ ID Nos disclosed therein. The disclosure also covers polypeptides (uPEPs) encoded by uORFs within sequences set forth in additional specified SEQ ID NOs or their homologous nucleotide sequences.

The invention provides a circadian rhythm evaluation method and system oriented to cardiovascular states, and belongs to the field of transcriptional gene analysis, and the method comprises the steps: obtaining transcriptome data at a single time point; gene expression data are positioned and extracted from the transcriptome data through a preset rhythm homeostasis gene module, and the rhythm homeostasis gene module is constructed through a weighted gene co-expression network analysis algorithm; and calculating the collaboration, the volatility and the network concentration degree of the gene expression data based on a dynamic network biomarker algorithm, and determining the circadian rhythm disorder index of the to-be-evaluated user according to the collaboration, the volatility and the network concentration degree. According to the method, collaborative expression characteristics are systematically captured by using a rhythm homeostasis gene module, dependence on a small number of core clock gene signals is avoided, and quantitative calculation is carried out on the collaboration, volatility and network concentration ratio of gene expression data in the module based on a dynamic network biomarker algorithm; and an objective and quantifiable molecular evaluation index is provided for an individual rhythm state.

To provide a novel technology that regulates the expression of the clock gene.SOLUTION: A clock gene expression regulator contains α-monoglucosylrutin as an active ingredient.SELECTED DRAWING: None

The invention discloses an ancient clock inscription and texture point cloud projection analysis method based on a three-dimensional geometric model, and relates to the technical field of cultural heritage digitization, and the method comprises the following steps: S1, photogrammetry and point cloud reconstruction: obtaining multi-view image data of an ancient clock, and reconstructing a three-dimensional point cloud of the ancient clock based on a photogrammetry method; s2, geometric model construction: establishing a clock body geometric model based on the S-shaped function contour and rotational symmetry; s3, parameter fitting: fitting the clock body geometric model by using the three-dimensional point cloud of the ancient clock by adopting a Gauss-Helmert least square method so as to estimate the optimal parameters of the clock body geometric model; s4, performing regular gridding and projection; and S5, image enhancement and recognition. The ancient clock inscription and texture point cloud projection analysis method based on the three-dimensional geometric model can realize low-cost, high-precision and lossless digital identification.

The application discloses a yellow-feathered broiler feed conversion rate related CLOCK gene SNP molecular marker and application thereof, and belongs to the technical field of animal genetics and breeding and molecular biology. The SNP molecular marker polymorphism is G / A, is located at the 5903440th base of a chicken 27th chromosome CLOCK gene, and has an RS number of rs315082113. The SNP molecular marker polymorphism provided by the application is significantly related to a chicken feed conversion rate character, can be applied to selecting a chicken population with a low feed conversion rate character, improves the efficiency of a broiler industry, provides convenience and technical support for rapid breeding of a low feed conversion rate broiler, can effectively reduce feed costs in a production process, and improves economic benefits and competition of enterprises.

1. Name of the product in this design: Clock (99324). 2. Purpose of this design: for use in clocks and watches. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

1. Name of the designed product: clock music lamp (egg-shaped second generation). 2. Use of the designed product: for indoor lighting decoration, playing music, and displaying time. 3. Design points of the designed product: in shape. 4. Picture or photo that best indicates the design points: perspective view.

1. Name of the designed product: clock sound (jellyfish). 2. Use of the designed product: sound equipment with timing reminder function. 3. Design points of the designed product: in shape. 4. Picture or photo that best shows the design points: perspective view.

The invention relates to the technical field of chimes, in particular to a harmonic therapeutic healing health-care chime which comprises a suspension bracket, a chime group composed of a plurality of U-shaped sound tubes is suspended on the suspension bracket, openings of the U-shaped sound tubes are arranged downwards, and musical scales of the chime group adopt musical sound sequence combination with the fundamental frequency of 380Hz-500Hz. The chime provided by the invention adopts a pure yellow clock 432Hz fundamental frequency musical sound sequence combination, the smooth rhythm and penetrating power of the chime can effectively soothe the body, relax nerves and promote cell and body repair, and ultrasonic waves, infrasonic waves, second-order harmonic waves and third-order harmonic waves generated during playing can deconstruct and kill microorganisms and viruses, so that the therapeutic and healing value of expelling evil and eliminating diseases is fully exerted, and the chime has a good application prospect. The problem that a traditional chime is difficult to accurately adapt to the modern health care acoustic therapy and healing requirements is solved.

The present invention provides agents and other devices that can advance the phase of the circadian rhythm. [Solution] The body clock regulator contains bergamot oil, geranium oil, and cedarwood. It contains at least one of Virginia oil, citral, and β-caryophyllene. It contains an active ingredient that advances the phase of the expression rhythm of clock genes.

1. The name of the design product: clock sound box (DY66). 2. The use of the design product: for playing music. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

1. Name of the product in this design: Clock Sound (SCB-201). 2. Purpose of this design: This design is used for clocks and speakers. 3. The key design features of this product are its overall shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.