The invention relates to a medicine for treating the calculus of the urinary system, which is prepared from the following Chinese herbal medicines in parts by weight: 3 parts of radix aristolochiae, 3 parts of serissa foetida comm., 4 parts of pyrrosia lingua, 9 parts of herba lysimachiae, 4 parts of japanese fern spore, 5 parts of plantain seed, 3 parts of talcum powder, 3 parts of glauber's salt, 4 parts of otolithum sciaenae, 6 parts of sparrow-tongue, 4 parts of chicken's gizzard-membrane, 2 parts of licorice, 4 parts of succinum, 4 parts of trogopterus dung, 5 parts of lilac pink, 2 parts of ground beetle, 4 parts of vaxxaria seed, 3 parts of rhizoma zedoariae, 4 parts of twotooth achyranthes root, 4 parts of great burdock fruit, 3 parts of earthworm, 2 parts of scaly anteater, 3 parts of rhizoma alismatis, 3 parts of astragalus root, 3 parts of radix codonopsis pilosulae, 3 parts of turmeric, 2 parts of blister beetle and 4 parts of rhizoma sparganii; the medicine is prepared by pulverizing the Chinese herbal medicines according to the mixture ratio, adding 1-2% of pure gooey, stirring, braising for 100-120 minutes to prepare a pill after cooling. The medicine has the effects of reducing fever, removing dampness by diuresis, strengthening the spleen, supplementing qi, promoting blood circulation, dissolving stasis and the like, is used for treating renal calculus, ureteral calculus, vesical calculus and urethral calculus and can be used for treating oledocholithiasis, hepatolithiasis and cholecystolithiasis.