1437 results about "Bulk drug" patented technology

The invention discloses a traditional Chinese medicine preparation for treating cancer, which is prepared by 103 types of bulk drugs such as solidago decurrens, Chinese sage herb, hypericum japonicumand the like. A preparation method of the traditional Chinese medicine preparation comprises the following steps: preparing the bulk drugs into water extract by a conventional method; using the prepared water extract for preparing oral solution by a traditional method; drying the obtained water extraction, then conducting grinding and sieving; taking the throughs for extracting powder, and using the extracted powder for preparing tablets, granules, electuaries or capsules by a traditional method. The preparation method also can be as follows: sieving out the dust of the bulk drugs, conductinggrinding and sieving, taking the throughs, conducting disinfection and sterilization to obtain raw powder, and using the raw powder for preparing tablets, granules, electuaries or capsules by a traditional method. With drugs mixed rationally, the traditional Chinese medicine preparation addresses both the symptoms and root causes of cancer. The bulk drugs are frequently-used common Chinese drugs,have low preparation cost and small side effect, and can effectively enhance own immunity, attack pathogen while do not damage body. The traditional Chinese medicine preparation can cure various typesof cancer, particularly lung cancer, stomach cancer, liver cancer, esophageal cancer, pancreatic cancer, cervical cancer and breast cancer.

The invention discloses a traditional Chinese medicine composition for treating respiratory tract haze disoperation and a preparation method, the composition comprises the following bulk drugs by weight: 10-30 g of balloonflower root, 1-15g of Zhejiang fritillaria bulb, 1-15g of grosvenor momordica fruit and 1-15g of licorice. The traditional Chinese medicine composition has the efficacy of dispersing lung Qi, lifting airway self-cleaning capability and eliminating harmful substances, in vitro and clinical verifies that the traditional Chinese medicine composition has the accurate curative effect for preventing and treating respiratory tract haze disoperation without toxic and side-effect. The above materials are ground to crude powder and packed in a tea bag, and brewed by boiled water, or water is used for immersing the bulk drugs for 20 minutes, the water decoction is carried out for 15 minutes, the above materials are filtered for drinking as tea, and auxiliary materials and a corrigent are cooperated, an oral liquid, a syrup, a capsule, a particulate agent, a tablet and effervescence particles which can be accepted on pharmacy are prepared directly or indirectly through conventional procedures, and the traditional Chinese medicine composition can be clinically used for treating or preventing the respiratory tract diseases caused by the haze disoperation.

An intake to exit security system for high-volume pharmacies provides maximum security from tampering and assures accuracy. The system immediately assigns bar codes to shipments upon arrival and then tracks them through warehousing, bulk distribution, prescription dispensing and shipping to patients, hospitals and drugstores. Bar-coded lock neck devices secure bulk drug canisters to bar-coded dispensing machines at specified dispensing stations where the machines dispense drugs into pre-labeled prescription bottles according to prescription indicia on the labels. Bottles then undergo content analysis and certification before packaged and shipped to customers. A Ramon laser spectral analysis contrasts the bottle contents to a library of known spectral signatures of drugs, and the pharmacist is alerted to any detected difference. A simultaneously captured visual image of the pills enables the pharmacist visually to compare the contents to a library of known visual appearances of the drugs. Both analyses are recorded for prescriptions certified and forwarded to customers. Deviations are excised without disrupting flow of other prescriptions, and the system automatically reassigns an incorrectly filled prescription to another bottle which starts anew through the system. Full bottles of commonly used drugs and specialized containers for irregularly shaped objects, creams and ointments may be pre-filled and inventoried for later collation with prescription bottles at the packaging and shipping stage.

A method and apparatus for preparing uniform carbon-13 labeled biomass using a water soluble carbon-13 labeled carbon source, such as a [¹³C]-bicarbonate or [¹³C]-carbonate salt, is disclosed. The biomass is prepared in one or more sterile carboys filled with growth medium, in which acidity, oxygen, and biomass density are carefully monitored and maintained. By using a solid, water-soluble [¹³C]-bicarbonate or [¹³C]-carbonate salt as the sole carbon source, a biomass is provided which is uniformly and efficiently labeled with carbon-13. This method and apparatus is particularly useful for the growth of an edible carbon-13 labeled algal mass, with Spirulina platensis being a specific alga species. The biomass may be prepared in conformance with FDA current good manufacturing practice regulations, and may be harvested and formed into lyophilized bulk drug powder which may be further processed into various drug product forms which are useful for diagnostic tests or in pharmaceutical compositions.

The invention relates to an oxiracetam injection solution which comprises 1 weight portion of oxiracetam, 1.5 to 5.5 weight portions of glucose and 50 to 100 weight portions of injection water, wherein, the pH value of the injection solution is 3.8 to 4.5. The invention also provides a preparation method of the oxiracetam injection solution which comprises the steps as follows: a) the bulk drug oxiracetam and the glucose or sodium chloride are solved in the injection water under the temperature of 40 DEG C to 70 DEG C to obtain dissolved solution; b) the dissolved solution is cooled to the room temperature, active carbon is added for decolorizing, the active carbon is removed by filtering, proper quantity of water is complemented, and citric acid and sodium citrate are added to adjust the pH value to 3.8 to 4.5 to obtain the dissolved solution with adjusted pH value; c) an intermediate product after encapsulation is sterilized; and d) the product after the sterilization is packed. The oxiracetam injection solution manufactured by the prescription and the preparation method of the invention has good storage stability.

Disclosed is an oil soluble pesticide nm capsule and preparation method, having weight ration of: pesticide: 0.5-4%; high molecular compound: 8-25%; mixed-surfactant: 8-20%; cosurfactant 3-10%; crosslinking agent 0.5-1.0%; organic solvent 3-10%; water: added to 100%, wherein the high molecular compound is selected from sodium lignosulfonates, chitosan, gum arabic or glutin, one or two is/are selected for agglutination reaction, forming capsule skin of the nm capsule; the capsule core is pesticide bulk drug, selected from diflubenzuron, emamectin benzoate, abamectin, imidacloprid, ivermectin or highly active cypermethrin. The mixed-surfactant adopts nonionic surfactant and anionic surfactant for compound. The pesticide nm controlled release preparation prepared by the invention is easy in storage, high in stability, large in drug-loading rate and high in dispersion.

The invention relates to a preparation method for an iron sucrose bulk drug. The method comprises the following steps: (1) crystallization: the pH value of sucrose solution is adjusted to 1-4 with acetic acid, iron salt solution is added to the sucrose solution to form mixed liquor, the pH value of the mixed liquor is adjusted to 1-3 with Na2CO3 solution, then the mixed liquor is stirred and is continued to be added with the Na2CO3 solution until turbidity appears in the mixed liquor, the pH value of the mixed liquor is adjusted to 4-7, and then the mixed liquor is filtered and added with water to obtain iron cake solution; (2) complexing: the sucrose solution is heated and added with alkaline liquor for alkalization, and then the alkalized sucrose solution is added with the iron cake solution and stands for the night to obtain complexing solution; and (3) refining: the complexing solution after standing for the night is filtered, and the filtrate precipitates with 2-3 times of 95 percent of ethanol and is filtered to obtain the iron sucrose bulk drug. The invention has the advantages of simple process steps, easy control of the reaction processes, good product quality, high yieldand lower production cost and is a high-novelty preparation method for the iron sucrose bulk drug and the injection thereof.

The invention relates to a ceftizoxime sodium drug injection powder and a preparation method thereof, as well as a synthetic method of bulk drug ceftizoxime sodium. The ceftizoxime sodium drug injection powder consists of 100% ceftizoxime sodium, wherein the ceftizoxime sodium is pretreated, and the pretreatment is aseptic refining and/or grinding. The ceftizoxime sodium drug has the advantages of high purity, almost no impurity, better and more stable quality, better clarity and the like; and the synthetic method of bulk drug ceftizoxime sodium has lower bulk cost, less synthesis technology difficulty, mild reaction condition, stable and reliable yield and quality, and high purity and yield of products.

A provided forage for controlling hemorragic disease of grass carp comprises the following bulk drugs: radix astragali, epimedium, lycium barbarum, sophora flavescens, andrographis paniculata, cacumen platycladi, coptis, acanthopanax senticosus, Chinese gall, herba plantaginis, lygodium japonicum, ligusticum wallichii, haw, mint, artemisia capillaris, pasque flower, purslane, caulis dendrobii, ferula, bighead atractylodes rhizome, conyza japonica, alternanthera sessilis and licorice. The traditional Chinese medicine composition provided by the invention has the advantages of being efficient, small in toxic and side effects, high in safety, small in residue and the like, and is wide in source and low in cost.

The invention discloses a headspace gas chromatography method for determining the residual quantity of an organic solvent in a glycine bulk drug. The method is implemented under conditions that a DB-624 capillary column and a hydrogen flame ionization detector are used, sample inlet temperature is 150 DEG C, the detector temperature is 250 DEG C, high purity nitrogen is taken as carrier gas with flow rate being 2.2 mL/min, the split ratio is 10:1, headspace heating temperature is 80 DEG C, and equilibrium time is 35 min; besides, glycine is easily soluble in water and the 12 solvents are soluble in water to a certain degree, so that an aqueous solvent is adopted. The method can be used for simultaneously determining the residual quantity of the 12 organic solvents including methanol, ethanol, acetone, isopropanol, acetonitrile, dichloromethane, n-propanol, ethyl acetate, tetrahydrofuran, cyclohexane, n-butanol and toluene in the glycine bulk drug, has the characteristics of being easyto operate, quick, sensitive and accurate in result, and provides reference for effectively controlling the quality of the glycine raw material and ensuring medication safety.

The invention discloses a Chinese herbal extract for promoting hair growth and hair blacking and improving dandruff and application thereof. The extract is obtained by extraction of bulk drugs containing ginseng, American ginseng, polygonum multiflorum, rhubarb, dodder and other 57 traditional Chinese medicines. Specifically, each of the traditional Chinese medicines accounts for 0.5wt%-30wt%, and the total composition of the traditional Chinese medicines is 100wt%. The bulk drugs are grinded into powder, the powder is mixed with an organic solvent and water, and then extraction is carried out to obtain the Chinese herbal extract. After extraction, the bulk drugs can release a restoration leading factor, which can promote cell activation and has the function of promoting cell proliferation. Thus, the Chinese herbal extract provided by the invention can be applied to activation of hair follicle cells, activation of melanin cells and other aspects, and can be used as a skin, hair follicle and hair medicine related to the fields, or can be used as an active and auxiliary component of cosmeceutical products associated with the fields.

The invention relates to a refining method for a lansoprazole crude drug, which is characterized in that the lansoprazole sample is dissolved in anhydrous alcohol and stirred to complete dissolution, and activated carbon is added to be stirred, pumped and filtered; then the solution which is placed in a freezing chamber to freeze and crystallize is pumped and filtered to be dry, the filter cake is washed to be dry by the anhydrous alcohol, and white solid can be obtained; finally, the obtained white solid is dried in an oven, and the solid is turned over discontinuously during the drying until reaching constant weight. The preparation method for the lansoprazole crude drug is simple and convenient, high in refining yield, low in the total impurities of the refined lansoprazole and good in clarity after being prepared into injections.

The invention relates to a preparation method of iron sucrose injection. The method comprises the steps of (1) alkalization; (2) complexation; (3) alcohol precipitation; (4) powder collection, comprising the procedures of performing solid-liquid separation on alcohol precipitation solution by a centrifugal machine, spray drying the solid phase and collecting powder to obtain a bulk drug of the iron sucrose; (5) injection preparation, comprises the steps of adding the bulk drug of the iron sucrose in injection water to prepare a solution containing 100-300 mg of iron element in every milliliter, adding a 20-40% NaOH solution for alkalization, controlling a pH value at 11, heating and controlling a temperature at 40-80 DEG C, then adding 1-0.3% of activated carbon, stirring for 15-60 minutes, filtering with a 0.22 [mu]m micro-filtration membrane, heating with steam and controlling the temperature at 110-120 DEG C, and keeping the temperature for 30 minutes to obtain a finished product of the iron sucrose injection. The preparation method of the iron sucrose injection is simple in process steps, has easily controllable reaction process, good product quality, high yield and low production cost, and is a preparation method of the iron sucrose injection, with relatively high innovativeness.

The invention discloses a group of acyclovir sustained-release preparation combinations and a preparation method thereof. The group of acyclovir sustained-release preparation combinations is mainly prepared from acyclovir bulk drugs, medicinal sustained-release materials and other appropriate auxiliary materials. The acyclovir enteric sustained-release preparation provided by the invention can deaccelerate the release rate of main drugs, reduce the frequency of administration and improve the patient compliance. The acyclovir sustained-release preparation combination provided by the invention has the advantages of high quality controllability and stability of the preparation process.

The invention discloses a medicinal dripping pill for treating hypertension, which consists of composition intermediates of red infested rice, uncaria, dendrobium and polyethylene glycol. The intermediates of the dripping pill are prepared from dry paste of extract of bulk drug prepared by the prior method. The medicinal dripping pill has remarkable treatment effect and no side effects.

The present invention provides stable pharmaceutical compositions comprised of atorvastatin and sodium bicarbonate or L-arginine. The compositions are prepared as bulk drug compositions and also as oral dosage units, such as tablets or capsules. The compositions are useful for preparation of monolithic and bi-layer tablets containing atorvastatin as the only active agent or combined with one or more additional active agents. The compositions are useful for treating hypercholesterolemia and related conditions.

The invention provides a drug dressing for the burn treatment and a preparing method thereof. The drug dressing comprises the following bulk drugs calculated according to the parts by weight: each 0.6 to 1.5 parts of arnebia root, sanquisorba root, Chinese goldthread, pangolin, dark plum, Chinese gall, giant knotweed, coptis root, corktree bark, dahurian angelica, hyacinth bletilla, bornel, burnt hair and Vaseline, and 1.5 to 2.5 parts of dragon's blood resin; the drug dressing also comprises 20 to 60 parts of vegetable oil calculated according to the parts by weight; the method comprises the following steps that: the pangolin, the bornel, the burnt hair and the dragon's blood resin are ground into four drug powder; the other bulk drugs and the vegetable oil are put into an oil bath to be heated, the other bulk drugs are fired with a slow fire until golden, gruffs are fished out, and then drug oil is achieved; when the drug oil is cooled, the four drug powder are mixed into the drug oil, and is stirred uniformly. The dressing can create a moist and germfree local environment for the wounded area, and has the remarkable advantages that the anti-infection effect is good and the healing of wound surface is quick, so as to be applicable for military first aids, primary hospitals and families.

The invention relates to a medicament for curing cancer and a preparation method thereof. The medicament comprises a No.1 polypharmaceutical, a No.2 polypharmaceutical and a No.3 polypharmaceutical, wherein the No.1 polypharmaceutical comprises 31 flavors of traditional Chinese medicines including Glauber salt, kudzuvine root, red sange root, mongolian snakegourd, rhubarb, eucommia bark, and the like; the No.2 polypharmaceutical comprises 26 flavors of traditional Chinese medicines including Chinese clematis, dried rehamnnia root, sesame kernel, schisandra fruit, tangerine peel, coix seed, and the like; and the No.3 polypharmaceutical comprises 6 flavors of traditional Chinese medicines including liquorice, cogongrass rhizome, dandehon herb, mint, dendrobium stem and cyperus rotundus linn. The bulk drugs consisting of the No.1 polypharmaceutical, the No.2 polypharmaceutical and the No.3 polypharmaceutical are crushed firstly, the No.1 polypharmaceutical and the No.2 polypharmaceutical can be respectively prepared into capsules, tablets, drop pills, granulas, oral liquid and injection by corresponding technologies; and the No.3 polypharmaceutical can be prepared into fine powder medicinal tea or granulas. The medicament has the unique effects of inhibiting tumor and removing pain, suppressing metastasis, removing necrosis and promoting granulation, balancing nutrition, expelling toxin, increasing immunity, and the like. The surgery can be replaced for curing the cancer generally, and the radiotherapy and the chemotherapy are not used; the effective rate of preventing the caner is 100 percent, the radical rate to the early cancer is 100 percent, and the curative ratios of the caner of medium and late stages are respectively over 98 percent and over 70 percent; and the invention also has the advantages of omni-directional treatment, high curative ratio and no toxic side effect.

The invention relates to a method for determining fingerprint chromatography of radix astragali and ligusticum wallichii extract products, which comprises the following steps: 1)taking Radix Astragali and Ligusticum wallichii extract product fine powder, preciously weighing, adding methanol, performing ultrasonic extraction, filtering and drying a filtrate, dissolving residue by ethanol and metering volume, filtering by a filter membrane, taking a subsequent filtrate to obtain a tested object solution; 2)taking a ferulic acid reference substance, a senkyunolide I reference substance, a calycosin glucoside reference substance, an ononin reference substance, a calycosin reference substance and a fermlononetin reference substance, preciously weighing, respectively adding methanol to prepare a reference substance solution; and 3)respectively and preciously absorbing the tested object solution and the reference substance solution, and injecting a high efficiency liquid chromatography for determining to obtain the fingerprint chromatography of radix astragali and ligusticum wallichii extract products. The method has active effect for guiding clinical medication and effective feeding guidance to the bulk drugs during the production process, and ensuring the reliable quality; the method has the advantages of convenient and fast operation, so that similarity result can be obtained, the quality of the traditional Chinese medicinal materials radix astragali and ligusticum wallichii extract products can be evaluated, and the result is objective and accurate.

The invention discloses a preparation method of an ozagrel bulk drug. The method comprises the following steps of: bromating methyl ethyl cinnamate serving as a starting material with NBS (B-Bromosuccinimide) to obtain ethyl 4-bromomethylcinnamate; undergoing a condensation reaction on the ethyl 4-bromomethylcinnamate and imidazole to generate ozagrel ethyl ester; hydrolyzing under an alkaline condition; performing acid precipitation to obtain crude ozagrel; and refining to obtain an ozagrel bulk drug. Due to the adoption of the method, a method for refining catalysts, solvents and crude products used in each reaction step is improved, the product yield is high, the product quality is good, the use of toxic reagents and expensive reagents is avoided, little environmental pollution is caused, and the production cost is low. The method is suitable for industrial production, and is an improved and environmentally-friendly method for preparing the ozagrel bulk drug.

The invention relates to a traditional Chinese medicinal composition for traditional Chinese moxibustion treatment, comprising the bulk drugs in part by weight: 5-10 parts of moxa, 0.5-1.5 parts of frankincense, 0.5-1.5 parts of myrrh, 0.5-1.5 parts of agilawood, 0.5-1.5 parts of borneol and 0.5-1.5 parts of cassia twig. The invention also provides a preparation method and applications of the traditional Chinese medicinal composition. The invention has the advantages that the double treatment action of moxa and traditional Chinese medicine is played, the clinic curative effect is greatly improved, the power is continuous and permeated, and the warm range is large, so that the invention is applicable to various cold syndromes, asthenia syndrome, painful syndrome and stasis syndrome, can beused for treating various common diseases and difficult miscellaneous diseases on clinic, and also can be used for daily health care; and in the invention, the carrying is convenient, the operation is easy, the price is far lower than that of the common clinic diagnosis, and considerable economic benefit can be brought.

The invention relates to a traditional Chinese medicine for treating hyperpiesis and a preparation method, the medicine can effectively treat hyperpiesis and has double efficacy of herbal cuisine and diet therapy in treating hyperpiesis. The invention comprises the following bulk drugs: 10-45 of propolis powder, 9-40 of natto powder, 9-40 of wild jujube seed, 9-40 of gastrodia tuber, 8-30 of corn stigma, 8-30 of cassia seed, 8-25 of pagodatree flower powder, 8-25 of kudzuvine root, 5-15 of gambir plant, 5-15 of scutellaria laterifolia, 5-15 of haw, 2-10 of apocynum, 2-10 of earthworm, 2-10 of evodia fruit, 8-25 of selfheal, 5-15 of Chinese gentian root, 5-15 of antelope horn, 5-15 of bupleurum, 5-15 of red-rooted salvia, 2-10 of radish seed and 2-10 of Chinese magnoliavine, wherein the unit of weight is parts by weight.

The invention discloses a traditional Chinese medicine composition for treating liver cirrhosis and fibrosis and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared by the bulk drugs of radix salviae miltiorrhizae, black soya bean, red paeony root, ophiopogon root, astragalus root, radix codonopsis pilosulae, angelica, carapax amydae, rhizoma zedoariae, twotooth achyranthes root, Chinese yam, giant knotweed, hedyotis diffusa, fructus amomi and honey-fried licorice root. The prescription disclosed by the invention is complete in the matching of a monarch, a minister, an adjuvant and a conductant drug, is excellent in the efficacy of drugs, is flexible in application and has the comparatively obvious characteristic of traditional Chinese medicine. The traditional Chinese medicine composition disclosed by the invention has the actions of resisting the fibrosis, resisting hepatitis B virus (HBV) replication, improving the liver function, regulating the blood circulation of the liver, reinforcing the liver, softening hard masses, strengthening the spleen and the like; and the traditional Chinese medicine composition also has the actions of lowering the portal pressure, reducing the thickness of the spleen and improving the liver function. The traditional Chinese medicine composition disclosed by the invention has an obvious curative effect in the therapeutic action to the liver cirrhosis and fibrosis. In addition, the traditional Chinese medicine composition disclosed by the invention has an obvious action of resisting the liver cirrhosis and fibrosis of children.

The invention provides a standard fingerprint of fleabane phenol bulk drugs and preparations, an establishment method and application. The technical schemes comprise the determination of the standard fingerprint and the characteristic fingerprint peak of fleabane drug materials, the fleabane phenol bulk drugs and the preparations, and the application of the standard fingerprint in the aspects of extraction and processing, and quality control in the process of producing the fleabane phenol bulk drugs and the preparations. Therefore, the overall monitoring of the process and the quality from the fleabane drug materials to fleabane phenol bulk drugs and then the preparations can be realized, basic substances of the fleabane drug materials, the fleabane phenol bulk drugs and the preparations can be conveniently confirmed, and the production process and quality can be conveniently evaluated, and standard indications can be provided for subsequent process improvement and perfection.

The invention discloses an officinal and edible medicine, which is prepared from bulk drugs including folium mori, chrysanthemum, almond, selfheal, mint, platycodon grandiflorum, liquorice, rhizoma phragmitis, houttuynia cordata and honeysuckle. Ten bulk drugs are matched scientifically to achieve cooperative functions and are used for treating wind-heat type common cold, clearing away heat and toxic materials, clearing away the lung-heat, and treating hot eyes, headache, cough, dry mouth, swollen sore throat, phlegm-heat, breath with cough, chronic/acute pharyngitis, acute pneumonia and the like. In addition, nine bulk drugs are officinal and edible homologous bulk drugs and mild in property, can be eaten for a long time, has no side effect and can be eaten as food and medicine. The officinal and edible medicine can be prepared into herbal tea for eliminating summer-heat by cooling, healthy beverage or various dosage forms, and has wide taking range.

The invention relates to a plaster for treating muscles and bones diseases, the bulk drugs are composed of Radix Astragali, Angelica sinensis, Ligusticum wallichii, white peony root, dipsacus asperoides, eucommia, Loranthus mulberry mistletoe, rhizoma drynariae, cibotium rhizome, achyranthes root, safflower, Saposhnikovia divaricata, Lycopodii herb, speranskia herb, Radix Angelicae Pubescentis, Radix clematidis, Aconitum carmichaeli debx, Aconitum Carmichaeli, Strychnos nuxvomica, ground beetle, pseudo-ginseng, keel, native copper, Radix Aucklandiae, angelica dahurica, Herba Asari, Chinese cassia tree, frankincense, borneol, yellow lead and sesame oil. The plaster has the advantages of convenient usage, substantial curative effect as well as small toxic and side effect; after tests of 310patients with muscles and bones diseases, the total effective rate reaches 96.1%.