28 results about "Asarone" patented technology

The present invention relates to the field of medical technology, and more particularly to a method for constructing a characteristic spectrum for detoxification capsules. The present invention improves existing detoxification capsule quality standards by enabling simultaneous detection of chebulic acid, syringin, kaempferol-30-rutinoside, β-asarone, and asaraldehyde. Furthermore, the components of the formulation, such as chebulic acid, syringin, kaempferol-30-rutinoside, β-asarone, and asaraldehyde, are controlled, further ensuring the safety, uniformity, stability, and controllability of the product quality.

The invention relates to the technical field of traditional Chinese medicinal material detection, and particularly discloses an alpha-asarone extracting solution detection method and system based on a biosensor, and the method sequentially comprises the following steps: mixing medicinal material powder to be detected with an extraction solvent according to a certain solid-to-liquid ratio, and extracting volatile oil by adopting an ultrasonic or reflux method to obtain a crude extracting solution; volatile oil concentrated mother liquor is obtained; obtaining a standard solution; a combined-state electrode is obtained; obtaining electrochemical response data; and converting the electrochemical response data into the content of alpha-asarone in the sample according to the standard curve, and evaluating the precision, the recovery rate and the regeneration performance to obtain a final detection result. Recognition sites prepared by adopting the molecularly imprinted polymer are complementarily paired with template molecules in steric configuration, steric hindrance and key functional groups to realize specific recognition of alpha-asarone, so that false signals caused by matrix interference and non-specific adsorption are remarkably reduced; the electrochemical measurement method is extremely sensitive to electron transfer generated by surface bonding.

The invention discloses a traditional Chinese medicine composition for improving memory and concentration and a preparation method thereof, and relates to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-22 parts of fructus alpiniae oxyphyllae, 15-25 parts of radix astragali, 8-16 parts of ginseng, 10-20 parts of walnuts, 10-20 parts of radix puerariae, 6-14 parts of cornel pulp, 8-18 parts of radix rehmanniae, 10-20 parts of Chinese wolfberry fruits, 15-25 parts of spina date seeds, 8-16 parts of polygala tenuifolia, 6-14 parts of rhizoma acori graminei and 4-10 parts of earthworms. According to the traditional Chinese medicine composition for improving memory and concentration and the preparation method of the traditional Chinese medicine composition, polygala ketone contained in polygala tenuifolia can specifically up-regulate hippocampal BDNF expression and doubly repair memory pathway damage caused by alcohol, volatile asarone in acorus gramineus can penetrate a blood brain barrier, and the volatile asarone is compatible with polygala tenuifolia, so that the nerve stimulation threshold value of a single component can be reduced, the intelligence promoting effect can be improved, and the traditional Chinese medicine composition can be used for improving memory and concentration. The earthworm extract can inhibit the activity of lactic dehydrogenase in the brain, and the synergistic effect mechanism of the polygala tenuifolia, the rhizoma acori graminei and the earthworm can also play a role in preventing and treating the Alzheimer's disease.

A method for determining multi-characteristic components of ASDZW is provided. By optimizing the gradient elution program of high performance liquid chromatography (HPLC), strictly controlling the initial mobile phase ratio of the gradient elution program, cooperating with the selections of the chromatographic column and the mobile phase, the invention finally realizes the simultaneous, rapid and comprehensive determination of six characteristic components in ASDZW under the condition of a single wavelength; specifically, the six characteristic components are polygalaxanthone III, 3,6′-disinapoyl sucrose, ginseng saponin Rb1, β-asarone, dehydrotumulosic acid, and pachymic acid. The whole detection process is a single wavelength detection with high detection efficiency and short analysis time, and the detection limits of the six components are lower than 0.008 μg / mL, meaning this method has high sensitivity, good specificity, accurate results, and good reproducibility.

The invention provides a nerve soothing and mind stabilizing pill and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: cleaning, infiltrating, cutting, drying, performing high-pressure steam sterilization on genuine medicinal materials such as poria cocos, poria with hostwood, ginseng, polygala tenuifolia, rhizoma acori graminei and the like in a formula of the mind-tranquilizing and mind-tranquilizing pill, mixing and crushing at low temperature to obtain fine powder, adding refined honey to prepare pills, and finally coating with cinnabar powder to obtain the mind-tranquilizing and mind-tranquilizing pill. The contents of polygala-ketone III, 3, 6 '-dimustard acyl sucrose, ginsenoside Rb1, beta-asarone, dehydrotumoic acid, pachymic acid and calcium salt in the prepared nerve-soothing and mind-stabilizing pill are high, the loss of index components in the pelleting process is small, and the dissolution time limit and microbial limit of the pill meet the requirements of Chinese Pharmacopoeia of 2025 edition. The preparation process of the mind-tranquilizing and mind-stabilizing pill is stable, and the prepared mind-tranquilizing and mind-stabilizing pill can effectively improve cognitive impairment, inflammation and oxidative stress injury caused by insomnia.

The application belongs to the technical field of medicines, and particularly relates to application of alpha-asarone in preparation of a medicine for treating allergic rhinitis. The application aims at the problems of single drug target, prominent safety hazards and inability to block pathological progress from the root in the existing medicines for treating allergic rhinitis, takes alpha-asarone as an active ingredient, inhibits excessive activation of an inflammation pathway by activating an Nrf2 / HO-1 signal axis, and bidirectionally regulates expression balance of GPX4 and ACSL4 to inhibit ferroptosis and damage of a nasal epithelial barrier. Animal experiments prove that the alpha-asarone can significantly reduce allergic behaviors of model mice, relieve inflammation of nasal mucosa, reverse tissue remodeling, has high safety, and can be prepared into oral or nasal preparations, and provides a new treatment scheme with multiple target points for allergic rhinitis.

The invention belongs to the technical field of medicines, and discloses application of asarinol and derivatives thereof in treatment of the Dravet syndrome. The structural general formula of asarinol and the derivatives thereof is shown in (I). Researches find that in an scn1lab / zebra fish model, alpha-asarone, beta-asarone and derivatives thereof can reduce epilepsy-like discharge by 23%-93%, and the effect is obviously superior to that of stiripentanol and cannabidiol. Related pharmaceutical preparations can be prepared into capsules, dry suspensions or gels and the like, the dry suspensions are more suitable for children to take, and the capsules and the gels are suitable for adults to take. In addition, toxicological studies show that the compound is high in safety and free of remarkable developmental toxicity. The invention provides a safe and efficient novel treatment scheme for the Dravot syndrome and intractable epilepsy, and has important clinical transformation value. (I)

The present invention provides the use of α-asarone in the preparation of a drug for preventing or treating hemorrhagic stroke. The structure of α-asarone is shown in Formula I. It can significantly improve short-term neurological deficits and long-term learning and memory function in model rats, reduce cerebral edema, improve blood-brain barrier permeability, and prevent or alleviate brain tissue atrophy during the recovery period. It has a definite therapeutic effect on animal models of hemorrhagic stroke without significant toxic side effects, and is expected to become a promising drug for the prevention and treatment of hemorrhagic stroke. #imgabs0#

The present invention provides the use of α-asarone in the manufacture of a drug for preventing or treating hemorrhagic stroke, the structure of α-asarone is shown in formula I, which significantly improves short-term neurological function deficit and long-term learning memory function in model rats, relieves cerebral edema, improves blood-brain barrier permeability, and prevents or alleviates cerebral tissue atrophy in the recovery period, has obvious therapeutic effect on animal models of hemorrhagic stroke, has no obvious toxicity and side effects, and is expected to be a preventive / treatment drug for hemorrhagic stroke. [Formula 1] JPEG2024512842000012.jpg31163

The invention belongs to the technical field of biological medicines, and discloses an application of rhizoma acori graminei essential oil in preparation of drugs for preventing and treating sensorineural deafness, the rhizoma acori graminei essential oil is taken as a core effective component, key active substances of the rhizoma acori graminei essential oil are determined to be beta-asarone and isomethyleugenol, and the rhizoma acori graminei essential oil can be prepared into oral preparations and / or ear drops; animal experiments and human body safety tests prove that the rhizoma acori graminei essential oil can remarkably reduce noise-induced hearing threshold displacement, protect the integrity of cochlea outer hair cells and the banding synaptic function of inner hair cells and inhibit cochlea local inflammation pathway activation, and is non-toxic to main organs and free of skin and tympanic membrane irritation. The invention solves the technical problems of poor compliance, obvious side effects on the whole body and indefinite effective components of the existing sensorineural deafness prevention and treatment medicines, and provides a safe and effective prevention and treatment scheme with strong scene adaptability.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a construction method of a characteristic spectrum of a traditional Chinese medicine compound preparation for treating senile dementia. The method is creatively characterized in that detection of characteristic peaks is realized through extraction, preparation and purification of an extract and specific gradient selection under a specific mobile phase condition. According to the method, seven chemical components in the traditional Chinese medicine compound preparation can be analyzed, seven characteristic peaks including epimedin C, ginsenoside Rd, pachymic acid, dehydrotumuloic acid, alpha-asarone, polygala mountain ketone III and tenuigenin are identified, verification research on specificity, precision, repeatability and stability is carried out on the method, and it is proved that the method is accurate and reliable. The technical means is used as a method for overall evaluation of the traditional Chinese medicine compound preparation, and a quality control system of the traditional Chinese medicine compound preparation is comprehensively improved.

The invention discloses an anti-depression plant extract which is prepared from a ginseng extract, a rhizoma acori graminei extract, a polygala tenuifolia extract, a poria with hostwood extract, a dragon bone extract and an oyster extract. The formula comprises the following components in percentage by weight: 9.81% of a ginseng extract, 58.86% of a rhizoma acori graminei extract, 9.25% of a polygala tenuifolia extract, 12.26% of a poria with hostwood extract, 4.90% of a fossil fragments extract and 4.90% of an oyster extract. The concentration of the formula is 0.4 mu g / mL-1. 6 mu g / mL, preferably 0.8 mu g / mL. The invention relates to the technical field of anti-depression extracts. The anti-depression plant extract has obvious neuroprotection, anti-inflammation and neurotransmitter regulation effects by adopting total ginsenoside, has an anti-depression effect, effectively improves the depression state of a depression model rat by adopting beta-asarone, and has the anti-depression effect mainly by protecting hippocampal nerve synaptic plasticity and inhibiting neuroinflammation. Therefore, the rhizoma acori graminei extract has an anti-depression effect.

The embodiment of the invention belongs to the technical field of compounds, and relates to a compound and a preparation method thereof. The compound comprises main materials, and the main materials comprise at least two of rosemary, star anise, rhizoma acori graminei, eucalyptus leaves, clove, storax, star anise and basil. In the main body material, rosemary can stimulate a central nervous system; anethole in the star anise has an obvious excitation effect, and the rhizoma acori graminei contains beta-asarone and has the effects of inducing resuscitation and inducing resuscitation; the eucalyptus leaves have the effect of reflexibility to cause central nervous excitation; the mint can activate a TRPM8 coldness receptor to generate a cool feeling, the clove can stimulate nervous centralis through an olfactory pathway, and the storax can cooperate with other aromatic components to prolong the waking time; the basil has the effect of regulating dopamine release and enhancing attention, so that the combination of at least two of the main materials can refresh the brain, and the materials are mainly natural plant components and cannot cause addiction.

The invention discloses a medicine detection method, which can simultaneously determine the contents of beta-asarone, schizandrin, hyperoside, verbenin, morinda officinalis verbenin, glycyrrhizic acid and other components in a medicine, and can be used for quality control of the medicine.

A method for identification of characteristic components in a Kai-Xin-San by thin-layer chromatography (TLC) is provided, belonging to the technical field of pharmaceutical raw material detection and traditional Chinese medicine quality control. The method only needs to prepare two test solutions to simultaneously identify six characteristic components in the Kai-Xin-San, namely ginsenoside Rb1, ginsenoside Re, tenuifolin, β-asarone, dehydrotumulosic acid, and pachymic acid. An automatic TLC spotting instrument can ensure even sampling and flat chromatographic bands and the silica gel G thin-layer plates after spotting are placed in the steam of the optimized developing solvent to allow pre-saturation.

The application discloses a kind of β-asarone-polygala saponin supramolecular nanoparticles and its preparation and application method, belong to natural active ingredient nano preparation technical field.The supramolecular nanoparticles contain β-asarone and polygala saponin, and by β-asarone aqueous phase liquid and polygala saponin aqueous phase liquid after mixing, particle-like assembly is formed by ultrasonic treatment, stirring.Its preparation method includes respectively preparing β-asarone aqueous phase liquid and polygala saponin aqueous phase liquid, after mixing, ultrasonic treatment and stirring are carried out, again by centrifugation, washing, again centrifugation and freeze-drying obtain supramolecular nanoparticles.The present application does not need to introduce the external carrier material for constructing particle skeleton, is conducive to improving the preparation of β-asarone and polygala saponin utilization basis, can be used as active ingredient for preparing anti-lung cancer drug or anti-lung cancer drug composition.

The present invention provides an application of α-asarone in the preparation of a medicine for preventing or treating hemorrhagic strokes. α-asarone has the structure shown in formula I, and may significantly improve short-term neurological deficits and long-term learning and memory functions of model rats, reduce cerebral edema, improve the permeability of the blood-brain barrier, and prevent or mitigate the atrophy of brain tissue during a recovery period. α-asarone has a precise therapeutic effect on animal models of hemorrhagic stroke without obvious toxic side effects, and is expected to have great application prospects as a medicine for preventing / treating hemorrhagic strokes.

A synthesis method of alpha-asarone comprises the following steps: 1, 2, 4-trimethoxybenzene is sequentially subjected to an acylation reaction, a reduction reaction and a dehydration reaction, and a product is obtained; the acylation reaction comprises the following steps: reacting 1, 2, 4-trimethoxybenzene with an acylating agent to generate 2, 4, 5-trimethoxypropiophenone by using Lewis acid as a catalyst; the reduction reaction comprises the following steps: reacting 2, 4, 5-trimethoxy propiophenone with a reducing agent to generate 2, 4, 5-trimethoxy phenylpropanol; the dehydration reaction comprises the following step: under a catalytic condition, enabling 2, 4, 5-trimethoxy phenylpropanol and anhydride to generate alpha-asarone. The obtained alpha-asarone product is high in purity and low in impurity content; after the conventional intermediate purification operation is simplified, a qualified product can still be obtained, and the production efficiency can be obviously improved; the method is simple to operate, low in risk and suitable for industrial production.

The invention discloses a method for detecting beta-asarone in a Tibetan medicine Qipeng pill, which adopts high performance liquid chromatography, and is characterized in that the chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a chromatographic column of a filler, a mobile phase A is a 0.1% phosphoric acid aqueous solution, a mobile phase B is acetonitrile, and gradient elution is adopted. The method is good in separation degree, high in sensitivity, linear, good in stability and repeatability and suitable for detecting the content of beta-asarone in the Qipeng pill.

The application of β-asarone ether in the preparation of drugs for promoting myelin regeneration, for improving neurological dysfunction in organisms with myelin injury, inhibiting inflammatory demyelination in the central nervous system, and enhancing memory and cognitive function.

The application belongs to the technical field of cosmetic analysis and detection, and discloses a conjugated color-producing molecule based on asarin and a preparation method and application thereof. The preparation method of the conjugated color-producing molecule based on asarin comprises the following steps: mixing a quinone derivative solution, a dehydrating agent dispersion liquid and an asarin solution, performing a dehydration condensation reaction, and obtaining the conjugated color-producing molecule based on asarin; wherein the quinone derivative in the quinone derivative solution is lanshanqinone. The conjugated color-producing molecule based on asarin can respond to the change of the viscosity of a gel microzone, is helpful to judge the subtle change of the viscosity, has high sensitivity to the viscosity, has a relatively stable chemical structure, can exist in a complex gel for a long time, and has a very strong visual effect.

The invention relates to the technical field of medicines, in particular to a construction method of a specific chromatogram of a detoxification capsule. Compared with the prior art, the quality standard of the existing detoxification capsules is correspondingly improved, simultaneous detection of chebulinic acid, syringin, kaempferol-30-rutinoside, beta-asarone and asarone is realized, in addition, components such as chebulinic acid, syringin, kaempferol-30-rutinoside, beta-asarone and asarone in the preparation are controlled, and the quality of the detoxification capsules is improved. And safe, uniform, stable and controllable product quality is further ensured.

The invention relates to a compound, in particular to a medicine for treating cranial nerve dysfunction diseases, namely alpha-asarone and an isomer beta-asarone, the molecular formula is C12H16O3, the molecular weight is 208.26, the Chinese name is 2, 4, 5-trimethoxy-1-propenyl benzene, and a preparation prepared from the alpha-asarone and the isomer beta-asarone can be used for treating cranial nerve dysfunction diseases. The pharmaceutical composition is used for treating various memory, cognition, sensory integration and thinking function partial or all deficiency diseases caused by cranial nerve dysfunction, including Alzheimer's disease, dementia, encephalitis sequelae, cerebral palsy, children intellectual development disorder, autism, hyperactivity and the like.

The application discloses a fingerprint spectrum construction method of a traditional Chinese medicine composition containing polygala and ginseng, and comprises the following steps: traditional Chinese medicine composition test sample solution preparation; first control sample solution preparation; second control sample solution preparation; obtaining the traditional Chinese medicine composition fingerprint spectrum according to the results of high performance liquid chromatography detection of the traditional Chinese medicine composition test sample solution, the first control sample solution and the second control sample solution; wherein the control samples are polygalaxanthone III, 3,6'-di-glucosinolate sucrose, beta-asarone and pachymic acid. The application comprehensively and systematically analyzes the chemical components of the traditional Chinese medicine composition containing polygala and ginseng, and provides a theoretical basis for quality control and in-depth research on the pharmacodynamic material basis.

The invention provides a medicine for preventing cerebral arterial thrombosis as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: reacting beta-asarone with cysteine to obtain a beta-asarone / cysteine conjugate; mixing the neutrophile granulocyte membrane protein with nano cerium dioxide to prepare a bionic nano liposome; the preparation method comprises the following steps: co-incubating geraniin and a milk exosome to prepare a drug-loaded exosome, performing ultrasonic incubation on the drug-loaded exosome and a bionic nano-liposome to prepare a bionic fusion body, uniformly mixing the bionic fusion body with a beta-asarone / cysteine conjugate, and performing freeze drying to prepare the drug for preventing cerebral arterial thrombosis. The medicine for preventing cerebral arterial thrombosis has the advantages of low immunogenicity, good blood-brain barrier penetration rate, good stability and high oral utilization rate, improves the compliance of patients, reduces the cost, has good effects of preventing and treating cerebral arterial thrombosis, and has wide application prospects.

The present invention relates generally to an antibacterial composition. The antibacterial composition comprises essential oil, wherein the essential oil comprises thymol, eugenol, alpha-asarone, artanol, beta-eudesmol and patchouli alcohol. The invention also relates to a preparation method and application of the antibacterial composition. The antibacterial composition disclosed by the invention has excellent antibacterial activity on bacilli and cocci.

The present invention relates to the technical field of biomedicine, and provides an application of asarone in the preparation of a drug for treating and / or preventing ocular diseases, and a composition and an application thereof. For the purposes of the present invention, ocular diseases include diseases characterized by retinal ganglion cell damage, macular degeneration, cataracts, or dry eye syndrome; and asarone comprises at least one of alpha-asarone, beta-asarone, or gamma-asarone. The present invention also provides an asarone composition. The asarone or the asarone composition of the present invention is administered by eye drops, orally, or by injection, and can effectively reduce intraocular pressure, protect retinal ganglion cells, improve retinal function, reduce vascular leakage in neovascular age-related macular degeneration, reduce MDA content, reduce retinal cell apoptosis, increase tear secretion volume in dry eye syndrome, and inhibit visual dysfunction caused by dry age-related macular degeneration and macular degeneration. The present invention provides an effective prevention and treatment basis for asarone in the treatment and / or prevention of the described ocular diseases.

This invention discloses a method for detecting the content of components in Kaixin San (a traditional Chinese medicine formula). Based on high-performance liquid chromatography (HPLC), a method for detecting the content of components in Kaixin San is constructed. By adopting a suitable gradient elution program, especially by strictly controlling the initial mobile phase ratio of the gradient elution program, and by combining the selection of chromatographic column and mobile phase, the method can rapidly and comprehensively determine the content of six chemical components in Kaixin San under dual-wavelength conditions: polygalactosidone III, 3,6-disinyl sucrose, ginsenoside Re, ginsenoside Rb1, β-asarone, and α-asarone. The method has high sensitivity, good specificity, accurate results, and good reproducibility.