12 results about "Asarone" patented technology

A method for determining multi-characteristic components of ASDZW is provided. By optimizing the gradient elution program of high performance liquid chromatography (HPLC), strictly controlling the initial mobile phase ratio of the gradient elution program, cooperating with the selections of the chromatographic column and the mobile phase, the invention finally realizes the simultaneous, rapid and comprehensive determination of six characteristic components in ASDZW under the condition of a single wavelength; specifically, the six characteristic components are polygalaxanthone III, 3,6′-disinapoyl sucrose, ginseng saponin Rb1, β-asarone, dehydrotumulosic acid, and pachymic acid. The whole detection process is a single wavelength detection with high detection efficiency and short analysis time, and the detection limits of the six components are lower than 0.008 μg / mL, meaning this method has high sensitivity, good specificity, accurate results, and good reproducibility.

The application belongs to the technical field of medicines, and particularly relates to application of alpha-asarone in preparation of a medicine for treating allergic rhinitis. The application aims at the problems of single drug target, prominent safety hazards and inability to block pathological progress from the root in the existing medicines for treating allergic rhinitis, takes alpha-asarone as an active ingredient, inhibits excessive activation of an inflammation pathway by activating an Nrf2 / HO-1 signal axis, and bidirectionally regulates expression balance of GPX4 and ACSL4 to inhibit ferroptosis and damage of a nasal epithelial barrier. Animal experiments prove that the alpha-asarone can significantly reduce allergic behaviors of model mice, relieve inflammation of nasal mucosa, reverse tissue remodeling, has high safety, and can be prepared into oral or nasal preparations, and provides a new treatment scheme with multiple target points for allergic rhinitis.

The invention belongs to the technical field of biological medicines, and discloses an application of rhizoma acori graminei essential oil in preparation of drugs for preventing and treating sensorineural deafness, the rhizoma acori graminei essential oil is taken as a core effective component, key active substances of the rhizoma acori graminei essential oil are determined to be beta-asarone and isomethyleugenol, and the rhizoma acori graminei essential oil can be prepared into oral preparations and / or ear drops; animal experiments and human body safety tests prove that the rhizoma acori graminei essential oil can remarkably reduce noise-induced hearing threshold displacement, protect the integrity of cochlea outer hair cells and the banding synaptic function of inner hair cells and inhibit cochlea local inflammation pathway activation, and is non-toxic to main organs and free of skin and tympanic membrane irritation. The invention solves the technical problems of poor compliance, obvious side effects on the whole body and indefinite effective components of the existing sensorineural deafness prevention and treatment medicines, and provides a safe and effective prevention and treatment scheme with strong scene adaptability.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a construction method of a characteristic spectrum of a traditional Chinese medicine compound preparation for treating senile dementia. The method is creatively characterized in that detection of characteristic peaks is realized through extraction, preparation and purification of an extract and specific gradient selection under a specific mobile phase condition. According to the method, seven chemical components in the traditional Chinese medicine compound preparation can be analyzed, seven characteristic peaks including epimedin C, ginsenoside Rd, pachymic acid, dehydrotumuloic acid, alpha-asarone, polygala mountain ketone III and tenuigenin are identified, verification research on specificity, precision, repeatability and stability is carried out on the method, and it is proved that the method is accurate and reliable. The technical means is used as a method for overall evaluation of the traditional Chinese medicine compound preparation, and a quality control system of the traditional Chinese medicine compound preparation is comprehensively improved.

The invention discloses a medicine detection method, which can simultaneously determine the contents of beta-asarone, schizandrin, hyperoside, verbenin, morinda officinalis verbenin, glycyrrhizic acid and other components in a medicine, and can be used for quality control of the medicine.

The application discloses a kind of β-asarone-polygala saponin supramolecular nanoparticles and its preparation and application method, belong to natural active ingredient nano preparation technical field.The supramolecular nanoparticles contain β-asarone and polygala saponin, and by β-asarone aqueous phase liquid and polygala saponin aqueous phase liquid after mixing, particle-like assembly is formed by ultrasonic treatment, stirring.Its preparation method includes respectively preparing β-asarone aqueous phase liquid and polygala saponin aqueous phase liquid, after mixing, ultrasonic treatment and stirring are carried out, again by centrifugation, washing, again centrifugation and freeze-drying obtain supramolecular nanoparticles.The present application does not need to introduce the external carrier material for constructing particle skeleton, is conducive to improving the preparation of β-asarone and polygala saponin utilization basis, can be used as active ingredient for preparing anti-lung cancer drug or anti-lung cancer drug composition.

The present invention provides an application of α-asarone in the preparation of a medicine for preventing or treating hemorrhagic strokes. α-asarone has the structure shown in formula I, and may significantly improve short-term neurological deficits and long-term learning and memory functions of model rats, reduce cerebral edema, improve the permeability of the blood-brain barrier, and prevent or mitigate the atrophy of brain tissue during a recovery period. α-asarone has a precise therapeutic effect on animal models of hemorrhagic stroke without obvious toxic side effects, and is expected to have great application prospects as a medicine for preventing / treating hemorrhagic strokes.

The application of β-asarone ether in the preparation of drugs for promoting myelin regeneration, for improving neurological dysfunction in organisms with myelin injury, inhibiting inflammatory demyelination in the central nervous system, and enhancing memory and cognitive function.

The application belongs to the technical field of cosmetic analysis and detection, and discloses a conjugated color-producing molecule based on asarin and a preparation method and application thereof. The preparation method of the conjugated color-producing molecule based on asarin comprises the following steps: mixing a quinone derivative solution, a dehydrating agent dispersion liquid and an asarin solution, performing a dehydration condensation reaction, and obtaining the conjugated color-producing molecule based on asarin; wherein the quinone derivative in the quinone derivative solution is lanshanqinone. The conjugated color-producing molecule based on asarin can respond to the change of the viscosity of a gel microzone, is helpful to judge the subtle change of the viscosity, has high sensitivity to the viscosity, has a relatively stable chemical structure, can exist in a complex gel for a long time, and has a very strong visual effect.

The invention provides a medicine for preventing cerebral arterial thrombosis as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: reacting beta-asarone with cysteine to obtain a beta-asarone / cysteine conjugate; mixing the neutrophile granulocyte membrane protein with nano cerium dioxide to prepare a bionic nano liposome; the preparation method comprises the following steps: co-incubating geraniin and a milk exosome to prepare a drug-loaded exosome, performing ultrasonic incubation on the drug-loaded exosome and a bionic nano-liposome to prepare a bionic fusion body, uniformly mixing the bionic fusion body with a beta-asarone / cysteine conjugate, and performing freeze drying to prepare the drug for preventing cerebral arterial thrombosis. The medicine for preventing cerebral arterial thrombosis has the advantages of low immunogenicity, good blood-brain barrier penetration rate, good stability and high oral utilization rate, improves the compliance of patients, reduces the cost, has good effects of preventing and treating cerebral arterial thrombosis, and has wide application prospects.

The present invention relates generally to an antibacterial composition. The antibacterial composition comprises essential oil, wherein the essential oil comprises thymol, eugenol, alpha-asarone, artanol, beta-eudesmol and patchouli alcohol. The invention also relates to a preparation method and application of the antibacterial composition. The antibacterial composition disclosed by the invention has excellent antibacterial activity on bacilli and cocci.

This invention discloses a method for detecting the content of components in Kaixin San (a traditional Chinese medicine formula). Based on high-performance liquid chromatography (HPLC), a method for detecting the content of components in Kaixin San is constructed. By adopting a suitable gradient elution program, especially by strictly controlling the initial mobile phase ratio of the gradient elution program, and by combining the selection of chromatographic column and mobile phase, the method can rapidly and comprehensively determine the content of six chemical components in Kaixin San under dual-wavelength conditions: polygalactosidone III, 3,6-disinyl sucrose, ginsenoside Re, ginsenoside Rb1, β-asarone, and α-asarone. The method has high sensitivity, good specificity, accurate results, and good reproducibility.